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https://www.readbyqxmd.com/read/28324816/sex-differences-and-hormonal-modulation-of-ethanol-enhanced-risk-taking-in-rats
#1
Kathryn G Wallin-Miller, Jordyn Chesley, Juliana Castrillon, Ruth I Wood
BACKGROUND: Ethanol (EtOH) intake correlates with increased risk-taking, and sex differences exist in both EtOH use and risk-taking in humans and rats. However, the interaction of sex and gonadal hormones to affect risk-taking under the influence of EtOH has not been determined. This was the focus of the current study. METHODS: Adult Long-Evans rats (n=18 males and females) were gonadectomized and received hormone replacement at physiologic levels or blank implants (n=7-9/group)...
March 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28324107/functional-characterization-of-transient-receptor-potential-trp-channel-c5-in-female-murine-gonadotropes
#2
Andreas Beck, Viktoria Götz, Sen Qiao, Petra Weissgerber, Veit Flockerzi, Marc Freichel, Ulrich Boehm
Gonadotrope cells in the anterior pituitary gland secrete gonadotropins regulating gonadal function in mammals. Recent results have implicated Transient Receptor Potential (TRP) cation channels in pituitary physiology, however, if and how TRP channels contribute to gonadotrope function is not known. Here we report that 14 out of 28 TRP channels encoded in the mouse genome are expressed in murine gonadotropes with highest expression levels found for TRPC5 in juvenile females. We show that TRP channel expression in these cells exhibits considerable plasticity and that it depends on gender as well as on the developmental and hormonal status of the animal...
January 30, 2017: Endocrinology
https://www.readbyqxmd.com/read/28324054/ccdc141-mutations-in-idiopathic-hypogonadotropic-hypogonadism
#3
Ihsan Turan, B Ian Hutchins, Bulent Hacihamdioglu, L Damla Kotan, Fatih Gurbuz, Ayca Ulubay, Eda Mengen, Bilgin Yuksel, Susan Wray, A Kemal Topaloglu
Context: GnRH neurons originate outside the central nervous system in the olfactory placode and migrate into the CNS, becoming integral components of the hypothalamic-pituitary-gonadal axis. Failure of this migration can lead to Idiopathic Hypogonadotropic Hypogonadism (IHH)/Kallmann Syndrome (KS). We have previously shown that CCDC141 knockdown leads to impaired migration of GnRH neurons but not of olfactory receptor neurons. Objective: The aim of this study was to further describe the phenotype and prevalence of CCDC141 mutations in IHH/KS...
January 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28324015/paternally-inherited-dlk1-deletion-associated-with-familial-central-precocious-puberty
#4
Andrew Dauber, Marina Cunha-Silva, Delanie B Macedo, Vinicius N Brito, Ana Paula Abreu, Stephanie A Roberts, Luciana R Montenegro, Melissa Andrew, Andrew Kirby, Matthew T Weirauch, Guillaume Labilloy, Danielle S Bessa, Rona S Carroll, Dakota C Jacobs, Patrick E Chappell, Berenice B Mendonca, David Haig, Ursula B Kaiser, Ana Claudia Latronico
Context: Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis. Few genetic causes of CPP have been identified with the most common being mutations in the paternally expressed imprinted gene MKRN3. Objective: To identify the genetic etiology of CPP in a large multigenerational family. Design: Linkage analysis followed by whole genome sequencing was performed in a family with 5 female members with nonsyndromic CPP...
January 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323958/jmjd3-is-crucial-for-female-avpv-rip-cre-neuron-controlled-kisspeptin-estrogen-feedback-loop-and-reproductive-function
#5
Anying Song, Shujun Jiang, Qinghua Wang, Jianghuan Zou, Zhaoyu Lin, Xiang Gao
The hypothalamic-pituitary-gonadal axis controls development, reproduction, and metabolism. While most studies were focusing on the hierarch from brain to gonad, many questions remain unresolved concerning the feedback from gonad to the central nervous system, especially on the potential epigenetic modification in hypothalamic neurons. In this report, we generated genetically modified mice lacking histone H3 lysine 27 demethylase JMJD3 in hypothalamic RIP-Cre neurons. The female mutant mice display late-onset obesity due to reduced locomotor activity and decreased energy expenditure...
March 9, 2017: Endocrinology
https://www.readbyqxmd.com/read/28319194/genome-wide-analysis-of-brain-and-gonad-transcripts-reveals-changes-of-key-sex-reversal-related-genes-expression-and-signaling-pathways-in-three-stages-of-monopterus-albus
#6
Wei Chi, Yu Gao, Qing Hu, Wei Guo, Dapeng Li
BACKGROUND: The natural sex reversal severely affects the sex ratio and thus decreases the productivity of the rice field eel (Monopterus albus). How to understand and manipulate this process is one of the major issues for the rice field eel stocking. So far the genomics and transcriptomics data available for this species are still scarce. Here we provide a comprehensive study of transcriptomes of brain and gonad tissue in three sex stages (female, intersex and male) from the rice field eel to investigate changes in transcriptional level during the sex reversal process...
2017: PloS One
https://www.readbyqxmd.com/read/28318602/metals-hormones-and-sexual-maturation-in-flemish-adolescents-in-three-cross-sectional-studies-2002-2015
#7
Sam De Craemer, Kim Croes, Nicolas van Larebeke, Stefaan De Henauw, Greet Schoeters, Eva Govarts, Ilse Loots, Tim Nawrot, Vera Nelen, Elly Den Hond, Liesbeth Bruckers, Yue Gao, Willy Baeyens
Sex hormone levels and timing of sexual maturation are considered important markers for health status of adolescents in puberty, and previous research suggests they might be influenced by metal exposure. In three campaigns of the Flemish Environment and Health Study (FLEHS I 2002-2006; FLEHS II 2007-2011 and FLEHS III 2012-2015), data were collected on internal exposure to metals (Cd, Cu, Pb, Cr, Mn, Tl, Ni, Sb, Hg, As and As species) and sexual maturation in 2671 14-15years old adolescents. All metals were measured in blood and/or urine, except total- and methylmercury which were measured in hair samples...
March 17, 2017: Environment International
https://www.readbyqxmd.com/read/28317246/brain-gene-expression-is-influenced-by-incubation-temperature-during-leopard-gecko-eublepharis-macularius-development
#8
Maria Michela Pallotta, Mimmo Turano, Raffaele Ronca, Marcello Mezzasalma, Agnese Petraccioli, Gaetano Odierna, Teresa Capriglione
Sexual differentiation (SD) during development results in anatomical, metabolic, and physiological differences that involve not only the gonads, but also a variety of other biological structures, such as the brain, determining differences in morphology, behavior, and response in the breeding season. In many reptiles, whose sex is determined by egg incubation temperature, such as the leopard gecko, Eublepharis macularius, embryos incubated at different temperatures clearly differ in the volume of brain nuclei that modulate behavior...
March 20, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28317066/er%C3%AE-and-gnrh-co-localize-in-the-hypothalamic-neurons-of-the-south-american-plains-vizcacha-lagostomus-maximus-rodentia-caviomorpha
#9
Pablo Ignacio Felipe Inserra, Santiago Elías Charif, Noelia Paula Di Giorgio, Lucía Saucedo, Alejandro Raúl Schmidt, Nicolas Fraunhoffer, Julia Halperin, María Constanza Gariboldi, Noelia Paola Leopardo, Victoria Lux-Lantos, Candela Rocío Gonzalez, Alfredo Daniel Vitullo, Verónica Berta Dorfman
Gonadotropin-releasing hormone (GnRH) is the key regulator of the hypothalamic-pituitary-gonadal axis. Estradiol (E2) affects GnRH synthesis and delivery. Hypothalamic estrogen receptors (ER) modulate GnRH expression acting as transcription factors. The South American plains vizcacha, Lagostomus maximus, is able to ovulate up to 800 oocytes per reproductive cycle, and shows continuous folliculogenesis with pre-ovulatory follicle formation and an ovulatory event at mid-gestation. The aim of this work was to analyze the hypothalamic expression of ER in the vizcacha at different gestational time-points, and its relationship with GnRH expression, serum luteinizing hormone (LH) and E2...
March 19, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28315977/seasonal-expression-of-arginine-vasotocin-mrna-and-its-correlations-to-gonadal-steroidogenic-enzymes-and-sexually-dimorphic-coloration-during-sex-reversal-in-the-gilthead-seabream-sparus-aurata
#10
José J Reyes-Tomassini, Ten-Tsao Wong, Yonathan Zohar
Arginine vasotocin is a hormone produced in the hypothalamus of teleost fish that has been shown to regulate gonad development and sexual behavior. To study the role of arginine vasotocin in the gonadal cycle of the hermaphrodite gilthead seabream, Sparus aurata, we cloned the seabream arginine vasotocin (avt) complementary DNA (cDNA). We investigated the expression of brain avt throughout the gonad cycle using real-time quantitative PCR and compared its expression levels to the expression levels of two key gonadal steroidogenic enzymes, cyp19a1a and cyp11b2...
March 18, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28304108/differential-effects-of-zn-exposure-on-male-and-female-oysters-crassostrea-angulata-as-revealed-by-label-free-quantitative-proteomics
#11
Lianzhong Luo, Qinghong Zhang, Xue Kong, Heqing Huang, Weiwei You, Caihuan Ke
Oysters accumulate Zn as an adaptation to Zn exposure; however, it is not known whether male and female oysters respond differently to Zn exposure. Here, proteomic and real-time polymerase chain reaction analyses were used to investigate differential responses of male and female oysters (Crassostrea angulata) to Zn exposure. After exposure to 50 µg.L(-1) or 500 µg.L(-1) Zn for 30 days, gonads of female oysters accumulated more Zn than those of males, and gonadal development was accelerated in females but was abnormal in males...
March 17, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28302250/congenital-orbital-teratoma-with-unilateral-proptosis
#12
Rubina Gulzar, Ruqaiya Shahid, Talat Mirza
Teratoma is a rare tumor, containing structures originating from all three germinal layers. The most frequent location of teratoma is the gonads. Orbital teratoma is extremely rare. In 1969, Jensen reported that only 40 cases of orbital teratoma existed in the world. We describe a rare case of orbital teratoma in a 15-day girl who presented with marked proptosis of the left eye. The eyeball was embedded within the mass that could be seen all around the globe. Orbitectomy was performed with the impression of retinoblastoma...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28301762/sex-differences-in-binge-eating-gonadal-hormone-effects-across-development
#13
Kelly L Klump, Kristen M Culbert, Cheryl L Sisk
Eating disorders are highly sexually differentiated disorders that exhibit a female predominance in risk. Most theories focus on psychosocial explanations to the exclusion of biological/genetic influences. The purpose of this descriptive review is to evaluate evidence from animal and human studies in support of gonadal hormone effects on sex differences in binge eating. Although research is in its nascent stages, findings suggest that increased prenatal testosterone exposure in males appears to protect against binge eating...
March 16, 2017: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/28301534/the-spermatogenic-process-of-the-common-vampire-bat-desmodus-rotundus-under-a-histomorphometric-view
#14
Danielle Barbosa Morais, Luciano Carlos Heringer Porcaro Puga, Tarcízio Antônio Rêgo de Paula, Mariella Bontempo Duca Freitas, Sérgio Luis Pinto da Matta
Among all bat species, Desmodus rotundus stands out as one of the most intriguing due to its exclusively haematophagous feeding habits. However, little is known about their spermatogenic cycle. This study aimed at describing the spermatogenic process of common vampire bats through testicular histomorphometric characterization of adult specimens, spermatogenic production indexes, description of stages of the seminiferous epithelium cycle and estimative of the spermatogenic process duration. Morphometrical and immunohistochemical analyzes for bromodeoxiuridine were conducted under light microscopy and ultrastructural analyzes were performed under transmission electron microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28300875/short-term-buserelin-administration-induces-apoptosis-and-morphological-changes-in-adult-rat-testes
#15
Behnaz Khadivi, Tahmineh Peirouvi, Masumeh Zirak JavanmardI, Yousef Rasmi
PURPOSE: To investigate the effect of buserelin on gonadal structure and function in adult male rats. METHODS: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. RESULTS: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300473/cells-on-the-move-modulation-of-guidance-cues-during-germ-cell-migration
#16
Girish Deshpande, Justinn Barr, Offer Gerlitz, Lyubov Lebedeva, Yulii Shidlovskii, Paul Schedl
In Drosophila melanogaster the progenitors of the germ-line stem cells, the primordial germ cells (PGCs) are formed on the outside surface of the early embryo, while the somatic gonadal precursor cells (SGPs) are specified during mid-embryogenesis. To form the primitive embryonic gonad, the PGCs travel from outside of the embryo, across the mid-gut and then migrate through the mesoderm to the SGPs. The migratory path of PGCs is dictated by a series of attractive and repulsive cues. Studies in our lab have shown that one of the key chemoattractants is the Hedgehog (Hh) ligand...
March 16, 2017: Fly
https://www.readbyqxmd.com/read/28296881/transcriptomic-responses-to-environmental-temperature-by-turtles-with-temperature-dependent-and-genotypic-sex-determination-assessed-by-rnaseq-inform-the-genetic-architecture-of-embryonic-gonadal-development
#17
Srihari Radhakrishnan, Robert Literman, Jennifer Neuwald, Andrew Severin, Nicole Valenzuela
Vertebrate sexual fate is decided primarily by the individual's genotype (GSD), by the environmental temperature during development (TSD), or both. Turtles exhibit TSD and GSD, making them ideal to study the evolution of sex determination. Here we analyze temperature-specific gonadal transcriptomes (RNA-sequencing validated by qPCR) of painted turtles (Chrysemys picta TSD) before and during the thermosensitive period, and at equivalent stages in soft-shell turtles (Apalone spinifera-GSD), to test whether TSD's and GSD's transcriptional circuitry is identical but deployed differently between mechanisms...
2017: PloS One
https://www.readbyqxmd.com/read/28296279/an-immunohistochemical-approach-to-identify-the-sex-of-young-marine-turtles
#18
Boris M Tezak, Kathleen Guthrie, Jeanette Wyneken
Marine turtles exhibit temperature-dependent sex determination (TSD). During critical periods of embryonic development, the nest's thermal environment directs whether an embryo will develop as a male or female. At warmer sand temperatures nests tend to produce female-biased sex ratios. The rapid increase of global temperature highlights the need for a clear assessment of its effects on sea turtle sex ratios. However, estimating hatchling sex ratios at rookeries remains imprecise due to the lack of sexual dimorphism in young marine turtles...
March 13, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28295807/interaction-of-melatonin-and-gonadotropin-inhibitory-hormone-on-the-zebrafish-brain-pituitary-reproductive-axis
#19
Thangal Yumnamcha, Zeeshan Ahmad Khan, Chongtham Rajiv, Sijagurumayum Dharmajyoti Devi, Gopinath Mondal, Haobijam Sanjita Devi, Rupjyoti Bharali, Asamanja Chattoraj
Circadian cycles and photoperiod are known to influence reproductive physiology in several animals. Neuropeptides, such as gonadotropin-inhibitory hormone (GNIH) and gonadotropin-releasing hormone (GNRH), are influenced by melatonin in birds and mammals. The present study demonstrates the role of melatonin in oocyte maturation in the zebrafish (Danio rerio), via the brain-pituitary-reproductive axis, under different photic conditions. Melatonin was significantly higher both in the whole brain and ovary under continuous dark (DD) compared to continuous light (LL) conditions...
March 10, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28295754/age-related-changes-in-the-morphology-of-tanycytes-in-the-human-female-infundibular-nucleus-median-eminence
#20
Anne C M Koopman, Melanie Taziaux, Julie Bakker
Tanycytes have been emerging as key players in the neuroendocrine control of gonadotropin-releasing hormone (GnRH) release. Rodent studies have demonstrated that the structural relationship between tanycytes and GnRH terminals in the median eminence is highly dynamic, regulated by gonadal steroids and undergoes age-related changes. Our objective was to determine whether the number and organization of tanycytes changes throughout life in the female infundibular nucleus/median eminence (INF/ME) region. Post-mortem hypothalamic tissues were collected at the Netherlands Brain Bank and were stained for vimentin by immunohistochemistry...
March 14, 2017: Journal of Neuroendocrinology
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