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Spermiogenesis

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https://www.readbyqxmd.com/read/29036365/the-developmental-origin-and-compartmentalization-of-glutathione-s-transferase-omega-2-isoforms-in-the-perinuclear-theca-of-eutherian-spermatozoa
#1
Lauren E Hamilton, Genevieve Acteau, Wei Xu, Peter Sutovsky, Richard J Oko
The perinuclear theca (PT) is a condensed, non-ionic detergent resistant cytosolic protein layer encapsulating the sperm head nucleus. It can be divided into two regions: the subacrosomal layer (SAL), whose proteins are involved in acrosomal assembly during spermiogenesis and the postacrosomal sheath (PAS), whose proteins are implicated in sperm-oocyte interactions during fertilization. In continuation of our proteomic analysis of the PT, we have isolated two prominent PT derived proteins of 28- and 31-kDa from demembranated bovine sperm head fractions...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29025071/the-expression-characteristics-of-fam71d-and-its-association-with-sperm-motility
#2
Qian Ma, Yuchi Li, Manling Luo, Huan Guo, Shouren Lin, Jianbo Chen, Ye Du, Zhimao Jiang, Yaoting Gui
STUDY QUESTION: What are the features of FAM71D (Family with sequence similarity 71, member D) expression and is there an association between FAM71D expression and sperm motility? SUMMARY ANSWER: FAM71D, a novel protein exclusively expressed in the testis, is located in sperm flagella and is functionally involved in sperm motility. WHAT IS KNOWN ALREADY: Some testis-specific proteins have been reported as potential diagnostic biomarkers to evaluate the spermatogenesis process and sperm quality...
September 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29022902/differential-regulation-of-spermatogenic-process-by-lkb1-isoforms-in-mouse-testis
#3
Feifei Kong, Mei Wang, Xiaojing Huang, Qiuling Yue, Xiang Wei, Xiaowei Dou, Xiaoxu Peng, Yuanyuan Jia, Ke Zheng, Tinghe Wu, Jun Yan, Jing Li
Liver serine/threonine kinase B1 (LKB1) is a tumor suppressor associated with the pathogenesis of Peutz-Jeghers syndrome. Affected males are at increased risk of developing Sertoli cell tumors and display defective spermatogenesis. Male mice lacking the short isoform (Lkb1S) of Lkb1 were sterile and exhibited abnormal spermiogenesis. In addition to the short isoform, the long isoform of Lkb1 (Lkb1L) is also expressed in testis; however, the requirement of the long isoform for fertility and the functional difference between the isoforms remain unknown...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29018194/pnldc1-is-essential-for-pirna-3-end-trimming-and-transposon-silencing-during-spermatogenesis-in-mice
#4
Deqiang Ding, Jiali Liu, Kunzhe Dong, Uros Midic, Rex A Hess, Huirong Xie, Elena Y Demireva, Chen Chen
Piwi-interacting RNAs are small regulatory RNAs with key roles in transposon silencing and regulation of gametogenesis. The production of mature piwi-interacting RNAs requires a critical step of trimming piwi-interacting RNA intermediates to achieve optimally sized piwi-interacting RNAs. The poly(A)-specific ribonuclease family deadenylase PNLDC1 is implicated in piwi-interacting RNA trimming in silkworms. The physiological function of PNLDC1 in mammals remains unknown. Using Pnldc1-deficient mice, here we show that PNLDC1 is required for piwi-interacting RNA biogenesis, transposon silencing, and spermatogenesis...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28986724/progestin-is-important-for-testicular-development-of-male-turbot-scophthalmus-maximus-during-the-annual-reproductive-cycle-through-functionally-distinct-progestin-receptors
#5
Chengcheng Feng, Shihong Xu, Yifan Liu, Yanfeng Wang, Wenqi Wang, Jingkun Yang, Chunyan Zhao, Qinghua Liu, Jun Li
In teleost, sex steroid hormones are critical for reproduction. Progestin is known to promote spermiation. To further understand the functions of progestin via its receptors during the annual reproductive cycle in male turbot (Scophthalmus maximus), we observed testicular development, quantified several sex steroid hormones, detected the expression of progestin receptors, and measured various sperm parameters. Results showed that the turbot testicular structure was of the lobular type. During breeding season, a number of spermatocytes (stage III) developed into spermatids (stage IV), then differentiated into sperm during spermiogenesis (stage V), and finally regressed to spermatocytes (stage VI)...
October 6, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28965865/cell-polarity-and-cytoskeletons-lesson-from-the-testis
#6
REVIEW
Qing Wen, Dolores Mruk, Elizabeth I Tang, Chris K C Wong, Wing-Yee Lui, Will M Lee, Xiang Xiao, Bruno Silvestrini, C Yan Cheng
Cell polarity in the adult mammalian testis refers to the polarized alignment of developing spermatids during spermiogenesis and the polarized organization of organelles (e.g., phagosomes, endocytic vesicles, genetic materials, Golgi apparatus) in Sertoli cells and germ cells to support spermatogenesis. Without these distinctive features of cell polarity in the seminiferous epithelium, it is not possible to support the daily production of millions of sperm in the limited space provided by the seminiferous tubules in either rodent or human males through the adulthood...
September 28, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28964737/intraflagellar-transporter-protein-ift27-an-ift25-binding-partner-is-essential-for-male-fertility-and-spermiogenesis-in-mice
#7
Yong Zhang, Hong Liu, Wei Li, Zhengang Zhang, Xuejun Shang, David Zhang, Yuhong Li, Shiyang Zhang, Junpin Liu, Rex A Hess, Gregory J Pazour, Zhibing Zhang
Intraflagellar transport (IFT) is an evolutionarily conserved mechanism essential for the assembly and maintenance of most eukaryotic cilia and flagella. In mice, mutations in IFT proteins have been shown to cause several ciliopathies including retinal degeneration, polycystic kidney disease, and hearing loss. However, little is known about its role in the formation of the sperm tail, which has the longest flagella of mammalian cells. IFT27 is a component of IFT-B complex and binds to IFT25 directly. In mice, IFT27 is highly expressed in the testis...
September 27, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28950090/spermatogenesis
#8
Hitoshi Nishimura, Steven W L'Hernault
Most organisms consist of two cell lineages - somatic cells and germ cells. The former are required for the current generation, and the latter create offspring. Male and female germ cells are usually produced during spermatogenesis and oogenesis, which take place in the testis and the ovary, respectively. Spermatogenesis involves the differentiation of spermatogonial stem cells into spermatocytes via mitotic cell division and the production of haploid spermatids from the tetraploid primary spermatocytes via meiotic cell division...
September 25, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28949791/estrogen-through-estrogen-receptor-1-regulates-histone-modifications-and-chromatin-remodeling-during-spermatogenesis-in-adult-rats
#9
Kushaan Dumasia, Anita Kumar, Sharvari Deshpande, Nafisa H Balasinor
Estrogen receptors (ESR1 and ESR2) play crucial roles in various processes during spermatogenesis. To elucidate individual roles of ESRs in male fertility, we developed in vivo selective ESR agonist administration models. Adult male rats treated with ESR1 and ESR2 agonist for 60 days show spermatogenic defects leading to reduced sperm counts and fertility. While studying epigenetic changes in the male germ line that could have affected fertility, we earlier observed a decrease in DNA methylation and its machinery upon ESR2 agonist treatment...
September 26, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28947561/profiling-of-mirnas-in-porcine-germ-cells-during-spermatogenesis
#10
Xiaoxu Chen, Dongxue Che, Pengfei Zhang, Xueliang Li, Qingqing Yuan, Tian Tian Liu, Jiayin Guo, Tongying Feng, Ligang Wu, Mingzhi Liao, Zuping He, Wen Xian Zeng
Spermatogenesis includes mitosis of spermatogonia, meiosis of pachytene spermatocytes and spermiogenesis of round spermatids. MiRNAs as a ~22nt small noncoding RNA are involved in regulating spermatogenesis at post-transcriptional level. However, the dynamic miRNAs expression in the developmental porcine male germ cells remains largely undefined. In this study, we purified porcine spermatogonia, pachytene spermatocytes, and round spermatids using a STA-PUT apparatus. A small RNA deep sequencing and analysis were conducted to establish a miRNAs profiling in these male germ cells...
September 25, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28931160/reproductive-behavior-of-echinothrips-americanus-thysanoptera-thripidae
#11
Stephanie Krueger, Marcus Jilge, Laurence Mound, Gerald B Moritz
Most Thysanoptera possess a haplo-diploid reproductive mode and reproduce via arrhenotoky. Females can mature eggs successively throughout almost their entire life, but in most terebrantian thrips spermiogenesis is complete by adult male eclosion, and testes contain only mature spermatids. In parasitoid wasps this phenomenon of preadult spermiogenesis is described as prospermatogeny. It is unclear if prospermatogeny and this predetermined sperm quantity have implications for mating strategy and fitness. In this study, we give a detailed description of mating behavior of the thripine species Echinothrips americanus, which largely corresponds with the only available data of another species of this family, Frankliniella occidentalis (Thysanoptera: Thripidae)...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28923514/cell-polarity-and-planar-cell-polarity-pcp-in-spermatogenesis
#12
REVIEW
Haiqi Chen, Dolores D Mruk, Wing-Yee Lui, Chris K C Wong, Will M Lee, C Yan Cheng
In adult mammalian testes, spermatids, most notably step 17-19 spermatids in stage IV-VIII tubules, are aligned with their heads pointing toward the basement membrane and their tails toward the tubule lumen. On the other hand, these polarized spermatids also align across the plane of seminiferous epithelium, mimicking planar cell polarity (PCP) found in other hair cells in cochlea (inner ear). This orderly alignment of developing spermatids during spermiogenesis is important to support spermatogenesis, such that the maximal number of developing spermatids can be packed and supported by a fixed population of differentiated Sertoli cells in the limited space of the seminiferous epithelium in adult testes...
September 28, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28915631/in-vivo-autophagy-and-biogenesis-of-autophagosomes-within-male-haploid-cells-during-spermiogenesis
#13
Ping Yang, Nisar Ahmed, Lingling Wang, Hong Chen, Yasir Waqas, Tengfei Liu, Abdul Haseeb, Nasrullah Bangulzai, Yufei Huang, Qiusheng Chen
Autophagy is a unique catabolic pathway that is linked to several physiological processes. However, its role in the process of spermiogenesis is largely unknown. The aim of the current study was to determine the in vivo role of autophagy and the origin of autophagosome membrane biogenesis within male haploid cells. Our immunohistochemistry results demonstrated that LC3 and ATG7 localization were increased dramatically in round to elongated spermatids (haploid cells) towards the lumen of seminiferous tubules, however, poorly expressed in the early stages of germ cells near the basal membrane...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914256/mettl3-mettl14-mediated-mrna-n-6-methyladenosine-modulates-murine-spermatogenesis
#14
Zhen Lin, Phillip J Hsu, Xudong Xing, Jianhuo Fang, Zhike Lu, Qin Zou, Ke-Jia Zhang, Xiao Zhang, Yuchuan Zhou, Teng Zhang, Youcheng Zhang, Wanlu Song, Guifang Jia, Xuerui Yang, Chuan He, Ming-Han Tong
Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells (SSCs) produce haploid spermatozoa. This highly specialized process is precisely controlled at the transcriptional, posttranscriptional, and translational levels. Here we report that N(6)-methyladenosine (m(6)A), an epitranscriptomic mark regulating gene expression, plays essential roles during spermatogenesis. We present comprehensive m(6)A mRNA methylomes of mouse spermatogenic cells from five developmental stages: undifferentiated spermatogonia, type A1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes, and round spermatids...
October 2017: Cell Research
https://www.readbyqxmd.com/read/28882431/abnormal-retention-of-nuclear-lamina-and-disorganization-of-chromatin-related-proteins-in-spermatozoa-from-dpy19l2-deleted-globozoospermic-patients
#15
Marine Paci, Razan Elkhatib, Guy Longepied, Sylviane Hennebicq, Julien Bessonat, Blandine Courbière, Patrice Bourgeois, Nicolas Levy, Michael J Mitchell, Catherine Metzler-Guillemain
The aim of this study was to characterize the nuclear lamina (NL) and lamin chromatin-partners in spermatozoa from four DPY19L2-deleted globozoospermic patients. We tested for spermatid transcripts encoding lamins and their chromatin-partners emerin, LAP2α, BAF and BAF-L, by reverse transcriptase-PCR using spermatozoa RNA. We also determined the localization of lamin B1, BAF and BAF-L by immunofluorescent analysis of spermatozoa from all patients. In RNA from globozoospermic and control spermatozoa we detected transcripts encoding lamin B1, lamin B3, emerin, LAP2α and BAF-L, but not A-type lamins...
August 4, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28859251/comparative-sperm-protein-profiling-in-bulls-differing-in-fertility-and-identification-of-phosphatidylethanolamine-binding-protein-4-a-potential-fertility-marker
#16
L Somashekar, S Selvaraju, S Parthipan, S K Patil, B K Binsila, M M Venkataswamy, S Karthik Bhat, J P Ravindra
This study aimed to identify sperm proteomic signatures regulating sperm functions and fertility by: (i) comparing the sperm electrophoretic protein profiles and identifying the differentially abundant proteins among breeding bulls differing in fertility status and (ii) elucidating the possible role of one of the identified novel proteins, PEBP4 on sperm function and fertility. The grouping of bulls as fertile (n = 6) and low fertile (n = 6) was performed based on bull fertility index and infertile (n = 6) based on semen rejection rate (>33%)...
August 31, 2017: Andrology
https://www.readbyqxmd.com/read/28852571/glycerol-kinase-like-proteins-cooperate-with-pld6-in-regulating-sperm-mitochondrial-sheath-formation-and-male-fertility
#17
Yuxi Chen, Puping Liang, Yan Huang, Minyan Li, Xiya Zhang, Chenhui Ding, Junyan Feng, Zhen Zhang, Xueqing Zhang, Yuanzhu Gao, Qinfeng Zhang, Shanbo Cao, Haiyan Zheng, Dan Liu, Zhou Songyang, Junjiu Huang
Spermatids undergo the final steps of maturation during spermiogenesis, a process that necessitates extensive rearrangement of organelles such as the mitochondria. Male infertility has been linked to mitochondrial disorder, for example, hypospermatogenesis and asthenozoospermia. However, the mechanisms that regulate mitochondrial dynamics during spermiogenesis remain largely unknown. We found the glycerol kinase (Gyk)-like proteins glycerol kinase-like 1 (Gykl1) and glycerol kinase 2 (Gk2) were specifically localized to the mitochondria in spermatids...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28845020/is-transcription-in-sperm-stationary-or-dynamic
#18
Xiaoxia Ren, Xiaoli Chen, Zhenling Wang, Dong Wang
Transcriptional activity is repressed due to the packaging of sperm chromatins during spermiogenesis. The detection of numerous transcripts in sperm, however, raises the question whether transcriptional events exist in sperm, which has been the central focus of the recent studies. To summarize the transcriptional activity during spermiogenesis and in sperm, we reviewed the documents on transcript differences during spermiogenesis, in sperm with differential motility, before and after capacitation and cryopreservation...
October 18, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28820536/atp7a-and-atp7b-regulate-copper-homeostasis-in-developing-male-germ-cells-in-mice
#19
Mateusz Ogórek, Małgorzata Lenartowicz, Rafał Starzyński, Aneta Jończy, Robert Staroń, Andrzej Doniec, Wojciech Krzeptowski, Aleksandra Bednarz, Olga Pierzchała, Paweł Lipiński, Zenon Rajfur, Zbigniew Baster, Patrycja Gibas-Tybur, Paweł Grzmil
The maintenance of copper homeostasis is critical for all cells. As learned from mice with disturbed copper metabolism, this trace element is also important for spermatogenesis. The experiments conducted in yeasts have demonstrated that appropriate copper level must be preserved to enable meiosis progression; however, increased copper level is toxic for cells. This study aims to analyze the expression profile of Atp7a and Atp7b and other genes encoding copper-related proteins during spermatogenesis in mice...
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28791602/ultrastructure-alterations-induced-by-gamma-irradiation-in-spermiogenesis-of-the-ground-beetle-blaps-sulcata-reference-to-environmental-radiation-protection
#20
Dalia Kheirallah, Lamia El-Samad, Naglaa Fahmi, Wafaa Osman
Ultrastructure alterations in spermiogenesis of the ground beetle, Blaps sulcata (Coleoptera: Tenebrionidae) were studied in normal adult males and in two male groups irradiated by gamma rays of 3 and 16 μSv/h dose rate. Ultrastructure examination of irradiated sperms revealed many alterations both in the head and in the flagellum regions of mature sperm. Alterations of the head region included nuclei with uncondensed chromatin materials and irregular nuclear envelope. Abnormal flagella contained malformed mitochondrial derivatives and damaged axonemes in addition to the absence of accessory bodies...
August 8, 2017: Environmental Science and Pollution Research International
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