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Spermiogenesis

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https://www.readbyqxmd.com/read/29436730/ultrastructural-description-of-the-spermatogenesis-and-spermatozoa-in-phaenocora-unipunctata-platyhelminthes-neotyphloplanida
#1
Rodrigo Ponce de León, Odile Volonterio
Ultrastructural studies of spermiogenesis and sperm morphology have found many characters that are likely to provide clues to the phylogeny of the Platyhelminthes. However, the lack of information on many free-living groups has been a limiting factor. There is a single description of the spermatogenesis and spermatozoa in a Phaenocora species, namely P. anomalocoela, therefore a similar analysis was made in Phaenocora unipunctata to compare the intrageneric variation of sperm ultrastructure and spermatogenesis in the Neotyphloplanida...
February 13, 2018: Journal of Morphology
https://www.readbyqxmd.com/read/29436366/spermiogenesis-and-spermatozoon-ultrastructure-in-basal-polyopisthocotylean-monogeneans-hexabothriidae-and-chimaericolidae-and-their-significance-for-the-phylogeny-of-the-monogenea
#2
Jean-Lou Justine, Larisa G Poddubnaya
Sperm ultrastructure provides morphological characters useful for understanding phylogeny; no study was available for two basal branches of the Polyopisthocotylea, the Chimaericolidea and Diclybothriidea. We describe here spermiogenesis and sperm in Chimaericola leptogaster (Chimaericolidae) and Rajonchocotyle emarginata (Hexabothriidae), and sperm in Callorhynchocotyle callorhynchi (Hexabothriidae). Spermiogenesis in C. leptogaster and R. emarginata shows the usual pattern of most Polyopisthocotylea with typical zones of differentiation and proximo-distal fusion of the flagella...
2018: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29410206/regulation-of-spermatid-polarity-by-the-actin-and-microtubule-mt-based-cytoskeletons
#3
REVIEW
Linxi Li, Baiping Mao, Siwen Wu, Qingquan Lian, Ren-Shan Ge, Bruno Silvestrini, C Yan Cheng
It is conceivable that spermatid apico-basal polarity and spermatid planar cell polarity (PCP) are utmost important to support spermatogenesis. The orderly arrangement of developing germ cells in particular spermatids during spermiogenesis are essential to obtain structural and nutrient supports from the fixed number of Sertoli cells across the limited space of seminiferous epithelium in the tubules following Sertoli cell differentiation by ∼17 day postpartum (dpp) in rodents and ∼12 years of age at puberty in humans...
February 5, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29408990/leydig-cell-genes-change-their-expression-and-association-with-polysomes-in-a-stage-specific-manner-in-the-adult-mouse-testis
#4
Estela J Jauregui, Debra Mitchell, Savanna M Garza, Traci Topping, Cathryn A Hogarth, Michael D Griswold
Spermatogenesis in mammals occurs in a very highly organized manner within the seminiferous epithelium regulated by different cell types in the testis. Testosterone produced by Leydig cells regulates blood-testis barrier formation, meiosis, spermiogenesis, and spermiation. However, it is unknown whether Leydig cell function changes with the different stages of the seminiferous epithelium. This study utilized the WIN 18,446 and retinoic acid (RA) treatment regime combined with the RiboTag mouse methodology to synchronize male germ cell development and allow for the in vivo mapping of the Leydig cell translatome across the different stages of one cycle of the seminiferous epithelium...
February 2, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29398303/low-mitochondrial-activity-within-developing-earthworm-male-germ-line-cysts-revealed-by-jc-1
#5
Karol Małota, Sebastian Student, Piotr Świątek
The male germ-line cysts that occur in annelids appear to be a very convenient model for spermatogenesis studies. Germ-line cysts in the studied earthworm are composed of two compartments: (1) germ cells, where each cell is connected via one intercellular bridge to (2) an anuclear central cytoplasmic mass, the cytophore. In the present paper, confocal and transmission electron microscopy were used to follow the changes in the mitochondrial activity and ultrastructure within the cysts during spermatogenesis...
February 1, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29393537/mouse-meiosis-expressed-gene-1-is-not-phosphorylated-in-vivo
#6
Wei Li, Amy S Miner, Ling Zhang, Paul Ratz, Zhibing Zhang
Mouse meiosis expressed gene 1 (Meig1) was originally cloned in a search for genes essential for meiosis. Early studies suggested that the protein forms a dimer and is phosphorylated in male germ cells. However, studies from our laboratory demonstrated that the gene is critical for the final phase, spermiogenesis. As a monomer, MEIG1 binds to PACRG through a specific domain on the protein surface. Here by using 2D Western blot analysis and the Pro-Q Diamond phosphoprotein gel stain, we show that mouse MEIG1 does not undergo major phosphorylation in the testis...
February 2, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29392466/spermatozoa-production-in-male-varroa-destructor-and-its-impact-on-reproduction-in-worker-brood-of-apis-mellifera
#7
Claudia Katharina Häußermann, Bettina Ziegelmann, Peter Rosenkranz
Reproduction in Varroa destructor exclusively takes place within the sealed honey bee brood cell and is, therefore, limited by the duration of the postcapping period. Oogenesis, ontogenetic development and mating must be optimized to ensure the production of as many mated daughter mites as possible. One adult male mite has to mate with up to five sister mites and transfer 30-40 spermatozoa to each female. We analyzed the production and transfer of male spermatozoa during a reproductive cycle by counting all spermatozoa in the genital tracts of the male and daughter mites in 80 worker brood cells at defined times after cell capping...
February 1, 2018: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29386567/mgat1-and-complex-n-glycans-regulate-erk-signaling-during-spermatogenesis
#8
Barnali Biswas, Frank Batista, Subha Sundaram, Pamela Stanley
Mechanisms that regulate spermatogenesis in mice are important to define as they often apply to fertility in man. We previously showed that conditional deletion of the mouse Mgat1 gene (Mgat1 cKO) in spermatogonia causes a germ-cell autonomous defect leading to infertility. MGAT1 is the N-acetylglucosaminyltransferase (GlcNAcT-I) that initiates the synthesis of complex N-glycans. Mechanistic bases of MGAT1 loss were investigated in germ cells from 22- and 23-day males, before any changes in germ cell morphology were apparent...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382573/studies-on-reproductive-stress-caused-by-candidate-gram-positive-and-gram-negative-bacteria-using-model-organism-caenorhabditis-elegans
#9
Rajasekharan Sharika, Priya Subbaiah, Krishnaswamy Balamurugan
Microbial association with a host using model system C. elegans have been widely studied based on factors such as host survival, the mode of infection, disease pathogenesis and the role of various players regulated during infection. The influence of pathogenic microorganism on reproduction and associated issues has not been explored fully. The present study focuses on the impact of bacterial infection on male reproductive parameters such as spermatogenesis and spermiogenesis, including physiological aspects like tail morphology defect and underlying molecular mechanisms that have been perturbed...
January 27, 2018: Gene
https://www.readbyqxmd.com/read/29360606/the-expression-pattern-and-potential-functions-of-phb-in-the-spermiogenesis-of-phascolosoma-esculenta
#10
Cong-Cong Hou, Xin-Ming Gao, Jie Ni, Dan-Li Mu, Hai-Yan Yang, Cheng Liu, Jun-Quan Zhu
Prohibitin (PHB) is a ubiquitous, evolutionarily conserved protein that is mainly localized in the inner mitochondrial membrane and exerts various mitochondrial functions. Here, we first cloned the phb gene from P. esculenta. The Pe-PHB protein has high homology and a similar protein structure to that of other animals, and it can be divided into the N-terminal hydrophobic/transmembrane domain, SPFH domain, and C-terminal coiled-coil domain. The Pe-phb gene is widely expressed, and the gene expression of phb is highest in coelomic fluid where spermiogenesis occurs, indicating a specific function in the coelom...
January 19, 2018: Gene
https://www.readbyqxmd.com/read/29330334/detection-of-heterozygous-mutation-in-hook-microtubule-tethering-protein-1-in-three-patients-with-decapitated-and-decaudated-spermatozoa-syndrome
#11
Huixing Chen, Yong Zhu, Zijue Zhu, Erlei Zhi, Keming Lu, Xiaobo Wang, Feng Liu, Zheng Li, Weiliang Xia
BACKGROUND: The mechanism of intramanchette transport is crucial to the transformation of sperm tail and the nuclear condensation during spermiogenesis. Although few dysfunctional proteins could result in abnormal junction between the head and tail of spermatozoon, little is known about the genetic cues in this process. OBJECTIVE: Based on patients with severe decapitated and decaudated spermatozoa (DDS) syndrome, the study aimed to validate whether new mutation exists on their Hook microtubule-tethering protein 1 (HOOK1) genes and follow their results of assisted reproduction treatment (ART)...
January 12, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29288959/ivermectin-acute-administration-impaired-the-spermatogenesis-and-spermiogenesis-of-adult-rats
#12
Flora Cordeiro, Vagner Gonçalves, Natalia Moreira, João Iosif Slobodticov, Nathalia de Andrade Galvão, Helenice de Souza Spinosa, Leoni Villano Bonamin, Eduardo Fernandes Bondan, Claudia Helena Pastor Ciscato, Cláudia Maria Barbosa, Maria Martha Bernardi
Ivermectin (IVM) is an antiparasitic agent widely used in agricultural, domestic animals and in human clinical practice. In the present study, the temporal effects of therapeutic doses of IVM in the morphometric and histological assessment of testis were studied to verify if IVM acute administration impaired the spermatogenesis and spermiogenesis of adult rats, if these effects are reversible. The testosterone levels and the plasmatic IVM levels were assessed. The results show: 1) IVM acute exposure, mainly in the higher dose, reduced the testicular volume, the tubular diameter and the germinal epithelium height; 2) no interferences on Leydig cells frequency; 3) histological studies show that tubular sections containing several histological changes indicative of spermatogenesis interruption, such as disorganization of germinal epithelium, vacuolar degeneration of the germ cells and sloughing of cells into the tubular lumen; 4) no differences in testosterone levels; 5) The IVM plasmatic levels were significantly reduced at 72h after the 0...
December 18, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29286340/slc9a3-protein-is-critical-for-acrosomal-formation-in-postmeiotic-male-germ-cells
#13
Ya-Yun Wang, Han-Sun Chiang, Chiao-Yin Cheng, Yi-No Wu, Yung-Chih Lin, Hsuan-Che Liu, Wei-Kung Tsai, Yen-Lin Chen, Ying-Hung Lin
Solute carrier family 9 isoform 3 (SLC9A3), a Na⁺/H⁺ exchanger, regulates the transepithelial absorption of Na⁺ and water and is primarily expressed on the apical membranes of the intestinal epithelium, renal proximal tubule, epididymis, and vas deferens. Loss of the Slc9a3 allele in mice enhances intestinal fluid and causes diarrhoea as a consequence of diminished Na⁺ and HCO₃- absorption. Hence, the loss also causes male infertility and reveals the abnormal dilated lumen of the rete testis and calcification in efferent ductules...
December 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29277349/diabetes-mellitus-induction-effect-of-different-streptozotocin-doses-on-male-reproductive-parameters
#14
Temidayo S Omolaoye, Bongekile T Skosana, Stefan S du Plessis
Diabetes mellitus (DM) is reported to be involved in male reproductive impairment, and its impact is evident in the increased prevalence of infertility. Various studies have reported that a single parenteral injection of <40 mg/kg Streptozotocin (STZ) is ineffective in ablating pancreatic β-cells and creating a rat model to investigate the effect of DM on the male reproductive system. This study therefore aims to validate these claims. Adult male Wistar rats received either a single intraperitoneal injection of STZ (30 mg/kg or 60 mg/kg) or saline (0...
December 22, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29274131/roles-of-p21-p53-cyclin-d1-cdk-4-estrogen-receptor-%C3%AE-in-aflatoxin-b1-induced-cytotoxicity-in-testicular-tissue-of-mice
#15
Toraj Zamir-Nasta, Mazdak Razi, Hasanzadeh Shapour, Hassan Malekinejad
This study was done in order to investigate time-dependent effect of AFB1 on expression of genes involving in cell cycle check point machinery at G, S, and M phases. For this purpose, 24 mature male Swiss albino mice were randomly divided into control and test groups. The animals in test group subdivided into three groups, which received the AFB1 at a daily dose of 20 µg/kg body weight, through intraperitoneal (i.p.) route, for 7, 14, and 21 days. The p21, p53, cyclin D1, CDK4, and ERα expressions at both mRNA and protein level were analyzed by using reverse transcription PCR (RT-PCR) and immunohistochemistry, respectively...
December 23, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29259204/ubiquitin-ligase-huwe1-modulates-spermatogenesis-by-regulating-spermatogonial-differentiation-and-entry-into-meiosis
#16
Rohini Bose, Kai Sheng, Adel R Moawad, Gurpreet Manku, Cristian O'Flaherty, Teruko Taketo, Martine Culty, Kin Lam Fok, Simon S Wing
Spermatogenesis consists of a series of highly regulated processes that include mitotic proliferation, meiosis and cellular remodeling. Although alterations in gene expression are well known to modulate spermatogenesis, posttranscriptional mechanisms are less well defined. The ubiquitin proteasome system plays a significant role in protein turnover and may be involved in these posttranscriptional mechanisms. We previously identified ubiquitin ligase Huwe1 in the testis and showed that it can ubiquitinate histones...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29247744/disruption-of-ssp411-causes-impaired-sperm-head-formation-and-male-sterility-in-mice
#17
Miao Liu, Yanfei Ru, Yihua Gu, Jianan Tang, Tiancheng Zhang, Jun Wu, Fudong Yu, Yao Yuan, Chen Xu, Jian Wang, Huijuan Shi
BACKGROUND: We previously cloned the Ssp411 gene. We found that the Ssp411 protein is predominantly expressed in elongated spermatids in the rat testis in a stage-dependent manner. Although our findings strongly suggested that Ssp411 might play an important role in mammalian spermatogenesis, this hypothesis has not been studied. METHODS: We first used real-time PCR, Western blotting and immunohistochemistry to confirm that the expression pattern of Ssp411 in several murine tissues is similar to its expression pattern in corresponding rat tissues...
December 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29247201/sox30-is-required-for-male-fertility-in-mice
#18
Chun-Wei Allen Feng, Cassy Spiller, Donna J Merriner, Moira K O'Bryan, Josephine Bowles, Peter Koopman
Male infertility is a major and growing problem and, in most cases, the specific root cause is unknown. Here we show that the transcription factor SOX30 plays a critical role in mouse spermatogenesis. Sox30-null mice are healthy and females are fertile, but males are sterile. In the absence of Sox30 meiosis initiates normally in both sexes but, in males, germ cell development arrests during the post-meiotic round spermatid period. In the mutant testis, acrosome and axoneme development are aberrant, multinucleated germ cells (symplasts) form and round spermatids unable to process beyond step 3 of spermiogenesis...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29246297/distinct-expression-profiles-and-novel-targets-of-micrornas-in-human-spermatogonia-pachytene-spermatocytes-and-round-spermatids-between-oa-patients-and-noa-patients
#19
Chencheng Yao, Qingqing Yuan, Minghui Niu, Hongyong Fu, Fan Zhou, Wenhui Zhang, Hong Wang, Liping Wen, Ligang Wu, Zheng Li, Zuping He
Human spermatogenesis includes three main stages, namely, the mitosis of spermatogonia, meiosis of spermatocytes, and spermiogenesis of spermatids, which are precisely regulated by epigenetic and genetic factors. Abnormality of epigenetic and genetic factors can result in aberrant spermatogenesis and eventual male infertility. However, epigenetic regulators in controlling each stage of normal and abnormal human spermatogenesis remain unknown. Here, we have revealed for the first time the distinct microRNA profiles in human spermatogonia, pachytene spermatocytes, and round spermatids between obstructive azoospermia (OA) patients and non-obstructive azoospermia (NOA) patients...
December 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29236364/intraflagellar-transporter-protein-140-ift140-a-component-of-ift-a-complex-is-essential-for-male-fertility-and-spermiogenesis-in-mice
#20
Yong Zhang, Hong Liu, Wei Li, Zhengang Zhang, Shiyang Zhang, Maria E Teves, Courtney Stevens, James A Foster, Gregory E Campbell, Jolene J Windle, Rex A Hess, Gregory J Pazour, Zhibing Zhang
Intraflagellar transport (IFT) is a conserved mechanism essential for the assembly and maintenance of most eukaryotic cilia and flagella. However, little is known about its role in sperm flagella formation and male fertility. IFT140 is a component of IFT-A complex. In mouse, it is highly expressed in the testis. Ift140 gene was inactivated specifically in mouse spermatocytes/spermatids. The mutant mice did not show any gross abnormalities, but all were infertile associated with significantly reduced sperm number and motility...
December 13, 2017: Cytoskeleton
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