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Ebola and amiodarone

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https://www.readbyqxmd.com/read/25933611/amiodarone-and-metabolite-mdea-inhibit-ebola-virus-infection-by-interfering-with-the-viral-entry-process
#1
Cristiano Salata, Aldo Baritussio, Denis Munegato, Arianna Calistri, Huy Riem Ha, Laurent Bigler, Fabrizio Fabris, Cristina Parolin, Giorgio Palù, Ali Mirazimi
Ebola virus disease (EVD) is one of the most lethal transmissible infections characterized by a high fatality rate, and a treatment has not been developed yet. Recently, it has been shown that cationic amphiphiles, among them the antiarrhythmic drug amiodarone, inhibit filovirus infection. In the present work, we investigated how amiodarone interferes with Ebola virus infection. Wild-type Sudan ebolavirus and recombinant vesicular stomatitis virus, pseudotyped with the Zaire ebolavirus glycoprotein, were used to gain further insight into the ability of amiodarone to affect Ebola virus infection...
July 2015: Pathogens and Disease
https://www.readbyqxmd.com/read/25414384/potential-and-emerging-treatment-options-for-ebola-virus-disease
#2
REVIEW
Bryan M Bishop
OBJECTIVE: To describe the current Ebola virus epidemic and the potential options for treatment and prevention of Ebola virus disease. DATA SOURCES: A PubMed literature search (1976 through October 20, 2014) was conducted using the search term Ebola. STUDY SELECTION AND DATA EXTRACTION: Animal and human studies published in English were selected. Studies published within the past 5 years were the primary focus of this review. DATA SYNTHESIS: The current Ebola virus epidemic has primarily been contained in West Africa though it has subsequently spread to other areas, including the United States...
February 2015: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/24710028/the-clinically-approved-drugs-amiodarone-dronedarone-and-verapamil-inhibit-filovirus-cell-entry
#3
Gerrit Gehring, Katrin Rohrmann, Nkacheh Atenchong, Eva Mittler, Stephan Becker, Franziska Dahlmann, Stefan Pöhlmann, Florian W R Vondran, Sascha David, Michael P Manns, Sandra Ciesek, Thomas von Hahn
OBJECTIVES: Filoviruses such as Ebola virus and Marburg virus cause a severe haemorrhagic fever syndrome in humans for which there is no specific treatment. Since filoviruses use a complex route of cell entry that depends on numerous cellular factors, we hypothesized that there may be drugs already approved for human use for other indications that interfere with signal transduction or other cellular processes required for their entry and hence have anti-filoviral properties. METHODS: We used authentic filoviruses and lentiviral particles pseudotyped with filoviral glycoproteins to identify and characterize such compounds...
August 2014: Journal of Antimicrobial Chemotherapy
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