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https://www.readbyqxmd.com/read/28058096/breast-ductal-carcinoma-in-situ-a-literature-review-of-adjuvant-hormonal-therapy
#1
REVIEW
Stephen Kinsey-Trotman, Zumin Shi, Beverley Fosh
This review paper analyzed publications of adjuvant tamoxifen and aromatase inhibitor use following surgery for breast ductal carcinoma in situ (DCIS). Key endpoint analyses were risk of invasive and noninvasive malignancies and new contralateral breast cancers. Metaanalysis of three studies showed a relative risk of 0.69 (95% confidence interval, 0.60-0.79, P<0.05) for breast malignancies with tamoxifen treatment in a mixed radiotherapy treatment/naïve cohort. Subgroup analysis of DCIS populations in multiple studies showed a trend to benefit with aromatase inhibitor treatment...
October 10, 2016: Oncology Reviews
https://www.readbyqxmd.com/read/28049817/global-urban-signatures-of-phenotypic-change-in-animal-and-plant-populations
#2
Marina Alberti, Cristian Correa, John M Marzluff, Andrew P Hendry, Eric P Palkovacs, Kiyoko M Gotanda, Victoria M Hunt, Travis M Apgar, Yuyu Zhou
Humans challenge the phenotypic, genetic, and cultural makeup of species by affecting the fitness landscapes on which they evolve. Recent studies show that cities might play a major role in contemporary evolution by accelerating phenotypic changes in wildlife, including animals, plants, fungi, and other organisms. Many studies of ecoevolutionary change have focused on anthropogenic drivers, but none of these studies has specifically examined the role that urbanization plays in ecoevolution or explicitly examined its mechanisms...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28048415/su-f-p-52-a-meta-analysis-of-controlled-clinical-trials-comparing-elective-nodal-irradiation-with-involved-field-irradiation-for-conformal-or-intensity-modulated-radiotherapy-in-patients-with-esophageal-cancer
#3
W Bai, R Zhang, Z Zhou, X Qiao
PURPOSE: To compare elective nodal irradiation with involved-field irradiation for three-dimensional conformal radiotherapy or intensity-modulated radiotherapy in patients with esophageal cancer by a metaanalysis. METHODS: Wanfang, CNKI, VIP, CBM databases, PubMed, Embase and Cochrane Library were searched to identify the controlled clinical trials of elective nodal irradiation with involved-field irradiation for three-dimensional conformal radiotherapy or intensity-modulated radiotherapy in patients with esophageal cancer...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28025609/indications-for-tonsillectomy-stratified-by-the-level-of-evidence
#4
REVIEW
Jochen P Windfuhr
Background: One of the most significant clinical trials, demonstrating the efficacy of tonsillectomy (TE) for recurrent throat infection in severely affected children, was published in 1984. This systematic review was undertaken to compile various indications for TE as suggested in the literature after 1984 and to stratify the papers according to the current concept of evidence-based medicine. Material and methods: A systematic Medline research was performed using the key word of "tonsillectomy" in combination with different filters such as "systematic reviews", "meta-analysis", "English", "German", and "from 1984/01/01 to 2015/05/31"...
2016: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/27980013/histopathological-classification-and-renal-outcome-in-patients-with-antineutrophil-cytoplasmic-antibodies-associated-renal-vasculitis-a-study-of-186-patients-and-metaanalysis
#5
Yong-Xi Chen, Jing Xu, Xiao-Xia Pan, Ping-Yan Shen, Xiao Li, Hong Ren, Xiao-Nong Chen, Li-Yan Ni, Wen Zhang, Nan Chen
OBJECTIVE: Renal vasculitis is one of the most common manifestations of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) and renal histology is a key predictor of the outcome. A new histopathologic classification was proposed and validated, but the results are still debated. METHODS: We performed a retrospective analysis to validate the histopathologic classification and performed a metaanalysis to evaluate its predictive value. There were 186 patients with ANCA-associated renal vasculitis diagnosed at Ruijin Hospital who were enrolled in the retrospective study...
December 15, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27980009/understanding-how-the-diagnostic-delay-of-spondyloarthritis-differs-between-women-and-men-a-systematic-review-and-metaanalysis
#6
Vega Jovaní, Mar Blasco-Blasco, M Teresa Ruiz-Cantero, Eliseo Pascual
OBJECTIVE: To identify empirical evidence of diagnostic delay in spondyloarthritis (SpA), determine whether sex-related differences persist, and conduct an analysis from that perspective of the possible causes, including the influence of quality research, in this group of inflammatory rheumatic diseases. METHODS: A systematic review was done of delay in diagnosis of SpA in MEDLINE and EMBASE and other sources. Study quality was determined in line with the Strengthening The Reporting of OBservational studies in Epidemiology (STROBE) statement...
December 15, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27969611/tct-25-efficacy-and-safety-of-left-atrial-appendage-closure-versus-medical-treatment-in-atrial-fibrillation-a-network-metaanalysis-from-randomized-trials
#7
Luis Nombela Franco, Shweta Sahay, Josep Rodés-Cabau, Pilar Jimenez, Pablo Salinas, Corina Biagioni, Ivan Nuñez-Gil, Nieves Gonzalo, Antonio Fernandez-Ortiz, Javier Escaned, Carlos Macaya
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27958695/aldosterone-receptor-antagonists-decrease-mortality-and-cardiovascular-hospitalizations-in-chronic-heart-failure-chf-with-reduced-left-ventricular-ejection-fraction-lvef-but-not-in-chf-with-preserved-lvef-a-meta-analysis-of-randomized-controlled-trials
#8
Renato DE Vecchis, Carmelina Ariano
INTRODUCTION: Aldosterone receptor antagonists (ARAs) were introduced in the treatment of chronic heart failure (CHF), as a result of the demonstration of their protective effect on the failing heart. However, important questions remain unanswered regarding the clinical efficacy of the ARAs on the clinical and echocardiographic phenotype of heart failure, called heart failure with preserved left ventricular ejection fraction( HFpEF). EVIDENCE ACQUISITION: The aim of the present meta-analysis was to verify the impact of the ARAs on some hard endpoints, such as all - cause death and hospitalizations from cardiovascular cause, making a comparative evaluation of these outcomes in CHF patients with reduced left ventricular ejection fraction (HFREF) and in those with HFpEF, respectively...
December 13, 2016: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/27956295/intraoperative-complications-of-phacoemulsification-in-pseudoexfoliation-%C3%A2-metaanalysis
#9
REVIEW
Pedro Vazquez-Ferreiro, Francisco J Carrera-Hueso, Jaime E Poquet Jornet, Narjis Fikri-Benbrahim, Marta Diaz-Rey, Rafael Sanjuan-Cerveró
: This review analyzed the effect of pseudoexfoliation (PXF) syndrome on the risk for surgical complications during phacoemulsification. Peer-reviewed literature in Medline, Embase, Lilacs, Web of Science, and Cochrane databases was systematically searched, along with gray literature in the Teseo and National Institutes of Health clinical trials database. Clinical trial, cohort, case-control, and cross-sectional studies comparing phacoemulsification complications in patients with and without PXF were identified, and 22 of 30 studies were selected for analysis...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27931841/new-molecular-therapies-in-patients-with-advanced-hepatocellular-cancer-in-second-line-of-treatment-is-a-real-defeat-results-from-a-literature-based-meta-analysis-of-randomized-trials
#10
REVIEW
Giandomenico Roviello, Laura Zanotti, Maria Rosa Cappelletti, Angela Gobbi, Giulia Borsella, Chiara Pacifico, Andrea Giovanni Multari, Daniele Generali
Several new biological agents have been investigated as second line of treatment in advanced Hepatocellular Cancer (HCC). We performed a meta-analysis to assess the effect of targeted therapies in advanced HCC patients beyond the first line of treatment. A literature-based metaanalysis of randomized controlled trials was undertaken. The primary outcome was the overall survival. The secondary endpoints were the progression-free survival (PFS), the response rate (RR) and disease control rate (DCR) and the safety...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27911795/klb-is-associated-with-alcohol-drinking-and-its-gene-product-%C3%AE-klotho-is-necessary-for-fgf21-regulation-of-alcohol-preference
#11
Gunter Schumann, Chunyu Liu, Paul O'Reilly, He Gao, Parkyong Song, Bing Xu, Barbara Ruggeri, Najaf Amin, Tianye Jia, Sarah Preis, Marcelo Segura Lepe, Shizuo Akira, Caterina Barbieri, Sebastian Baumeister, Stephane Cauchi, Toni-Kim Clarke, Stefan Enroth, Krista Fischer, Jenni Hällfors, Sarah E Harris, Saskia Hieber, Edith Hofer, Jouke-Jan Hottenga, Åsa Johansson, Peter K Joshi, Niina Kaartinen, Jaana Laitinen, Rozenn Lemaitre, Anu Loukola, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Ani Manichaikul, Hamdi Mbarek, Yuri Milaneschi, Alireza Moayyeri, Kenneth Mukamal, Christopher Nelson, Jennifer Nettleton, Eemil Partinen, Rajesh Rawal, Antonietta Robino, Lynda Rose, Cinzia Sala, Takashi Satoh, Reinhold Schmidt, Katharina Schraut, Robert Scott, Albert Vernon Smith, John M Starr, Alexander Teumer, Stella Trompet, André G Uitterlinden, Cristina Venturini, Anne-Claire Vergnaud, Niek Verweij, Veronique Vitart, Dragana Vuckovic, Juho Wedenoja, Loic Yengo, Bing Yu, Weihua Zhang, Jing Hua Zhao, Dorret I Boomsma, John Chambers, Daniel I Chasman, Toniolo Daniela, Eco de Geus, Ian Deary, Johan G Eriksson, Tõnu Esko, Volker Eulenburg, Oscar H Franco, Philippe Froguel, Christian Gieger, Hans J Grabe, Vilmundur Gudnason, Ulf Gyllensten, Tamara B Harris, Anna-Liisa Hartikainen, Andrew C Heath, Lynne Hocking, Albert Hofman, Cornelia Huth, Marjo-Riitta Jarvelin, J Wouter Jukema, Jaakko Kaprio, Jaspal S Kooner, Zoltan Kutalik, Jari Lahti, Claudia Langenberg, Terho Lehtimäki, Yongmei Liu, Pamela A F Madden, Nicholas Martin, Alanna Morrison, Brenda Penninx, Nicola Pirastu, Bruce Psaty, Olli Raitakari, Paul Ridker, Richard Rose, Jerome I Rotter, Nilesh J Samani, Helena Schmidt, Tim D Spector, David Stott, David Strachan, Ioanna Tzoulaki, Pim van der Harst, Cornelia M van Duijn, Pedro Marques-Vidal, Peter Vollenweider, Nicholas J Wareham, John B Whitfield, James Wilson, Bruce Wolffenbuttel, Georgy Bakalkin, Evangelos Evangelou, Yun Liu, Kenneth M Rice, Sylvane Desrivières, Steven A Kliewer, David J Mangelsdorf, Christian P Müller, Daniel Levy, Paul Elliott
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10(-12)). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans...
December 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27909496/safety-and-efficacy-of-uninterrupted-periprocedural-apixaban-in-patients-undergoing-atrial-fibrillation-catheter-ablation-a-metaanalysis-of-1-057-patients
#12
REVIEW
Jalaj Garg Md Fesc, Rahul Chaudhary Md, Parasuram Krishnamoorthy Md, Neeraj Shah Md, Babak Bozorgnia Md, Andrea Natale Md
Apixaban (factor Xa inhibitor) is a novel anticoagulant and may be beneficial during atrial fibrillation (AF) ablation for prevention of thromboembolic events. However, the adverse effects of periprocedural apixaban therapy have not been thoroughly evaluated. A meta-analysis was performed to evaluate the safety of apixaban for anticoagulation in AF ablation. We searched the online databases till October 2015 for studies comparing Apixaban with Vitamin K antagonists in atrial fibrillation patients undergoing catheter ablation...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27879314/genetic-variation-in-the-slc8a1-calcium-signaling-pathway-is-associated-with-susceptibility-to-kawasaki-disease-and-coronary-artery-abnormalities
#13
Chisato Shimizu, Hariklia Eleftherohorinou, Victoria J Wright, Jihoon Kim, Martin P Alphonse, James C Perry, Rolando Cimaz, David Burgner, Nagib Dahdah, Long T Hoang, Chiea Chuen Khor, Andrea Salgado, Adriana H Tremoulet, Sonia Davila, Taco W Kuijpers, Martin L Hibberd, Todd A Johnson, Atsushi Takahashi, Tatsuhiko Tsunoda, Michiaki Kubo, Toshihiro Tanaka, Yoshihiro Onouchi, Rae S M Yeung, Lachlan J M Coin, Michael Levin, Jane C Burns
BACKGROUND: Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies and linkage studies only partially explain the influence of genetics on KD susceptibility. METHODS AND RESULTS: To search for additional functional genetic variation, we performed pathway and gene stability analysis on a genome-wide association study data set...
December 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27852014/the-incidence-of-pressure-ulcers-in-the-emergency-department-a-metaanalysis
#14
Peng Liu, Wang-Qin Shen, Hong-Lin Chen
OBJECTIVE: The aim of this meta-analysis was to estimate the incidence of pressure ulcers (PUs) in the emergency department (ED). METHODS: The authors searched PubMed, Web of Science, and CINAHL databases for all time leading up to February 2016. The incidence of PUs in the ED were collected, and the pooled incidence with 95% confidence interval (CI) was calculated by meta-analysis. RESULTS: Six studies with 8 cohorts were included in this study...
October 24, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27803342/subclinical-synovitis-assessed-by-ultrasound-predicts-flare-and-progressive-bone-erosion-in-rheumatoid-arthritis-patients-with-clinical-remission-a-systematic-review-and-metaanalysis
#15
Jingjing Han, Yan Geng, Xuerong Deng, Zhuoli Zhang
OBJECTIVE: Subclinical synovitis can be detected by ultrasound in patients with rheumatoid arthritis (RA) who are in clinical remission. We aimed to confirm its predictive value for flare and progressive bone erosion. METHODS: A systematic literature search was performed in Pubmed, Web of Science, Embase, and Cochrane Library on September 7, 2014. Baseline clinical and ultrasonographic characteristics were collected. Methodological quality was assessed. Pooled OR were calculated using Mantel-Haenszel model...
November 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27791099/situating-the-default-mode-network-along-a-principal-gradient-of-macroscale-cortical-organization
#16
Daniel S Margulies, Satrajit S Ghosh, Alexandros Goulas, Marcel Falkiewicz, Julia M Huntenburg, Georg Langs, Gleb Bezgin, Simon B Eickhoff, F Xavier Castellanos, Michael Petrides, Elizabeth Jefferies, Jonathan Smallwood
Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN)...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27780561/minimally-invasive-extracorporeal-circulation-circuit-is-not-inferior-to-off-pump-coronary-artery-bypass-grafting-meta-analysis-using-the-bayesian-method
#17
REVIEW
Bernhard Winkler, Paul P Heinisch, Brigitta Gahl, Soheila Aghlmandi, Hans Jörg Jenni, Thierry P Carrel
The pathophysiologic side effects of cardiopulmonary bypass have already been identified. Minimally invasive extracorporeal circulation technologies (MiECT) and off-pump coronary artery bypass graft surgery (OPCABG) aim to reduce these problems. This meta-analysis provides a comparison of MiECT and OPCABG in randomized and observational studies. A fully probabilistic, Bayesian approach of primary and secondary endpoints was conducted. MiECT does not give inferior results when compared with OPCABG. However, there is a trend to borderline significantly higher blood loss in this group in randomized controlled trials...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27752890/hfe-genetic-variability-and-risk-of-alcoholic-liver-disease-a-meta-analysis
#18
Yan-Yan Xu, Yu-Han Tang, Xiao-Ping Guo, Jing Wang, Ping Yao
Studies examining the association of hemochromatosis (HFE) gene polymorphisms and susceptibility to alcoholic liver disease (ALD) yielded inconsistent results. Thus, we performed a metaanalysis to investigate whether the variations in HFE gene increase the risk of ALD. The studies published up to Feb. 2014 were identified by searching PubMed/MEDLINE, ISI Web of Science, EMBASE and China National Knowledge Infrastructure databases, which was complemented by screening the references of the retrieved studies. For all genotypes and alleles, the odds ratios (ORs) with 95% confidence intervals (CIs) according to the heterogeneity were pooled using fixed-effect model...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27744395/rheumatoid-arthritis-and-coronary-artery-disease-genetic-analyses-do-not-support-a-causal-relation
#19
Henning Jansen, Christina Willenborg, Wolfgang Lieb, Lingyao Zeng, Paola Gloria Ferrario, Christina Loley, Inke R König, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert
OBJECTIVE: Inflammatory diseases, specifically rheumatoid arthritis (RA), are assumed to increase the risk of coronary artery disease (CAD). More recently, multiple single-nucleotide polymorphisms (SNP) associated with RA risk were identified. If causal mechanisms affecting risks of RA and CAD are overlapping, risk alleles for RA might also increase the risk of CAD. METHODS: Sixty-one SNP associating with RA in genome-wide significant analyses were tested for association with CAD in CARDIoGRAM (Coronary ARtery DIsease Genome wide Replication and Meta-analysis), a metaanalysis including genome-wide association data (22,233 CAD cases, 64,762 controls)...
January 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/27660570/a-metaanalysis-of-interventions-to-improve-adherence-to-lipid-lowering-medication
#20
REVIEW
Richard E Deichmann, Michael D Morledge, Robin Ulep, Johnathon P Shaffer, Philippa Davies, Mieke L van Driel
BACKGROUND: Inadequate patient adherence to a medication regimen is a major factor in the lack of success in treating hyperlipidemia. Improved adherence rates may result in significantly improved cardiovascular outcomes in populations treated with lipid-lowering therapy. The purpose of this metaanalysis was to evaluate the effectiveness of interventions aimed at improving adherence to lipid-lowering drugs, focusing on measures of adherence and clinical outcomes. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature databases through January 14, 2015, and also used the results from previous Cochrane reviews of this title...
2016: Ochsner Journal
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