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https://www.readbyqxmd.com/read/27909496/safety-and-efficacy-of-uninterrupted-periprocedural-apixaban-in-patients-undergoing-atrial-fibrillation-catheter-ablation-a-metaanalysis-of-1-057-patients
#1
REVIEW
Jalaj Garg Md Fesc, Rahul Chaudhary Md, Parasuram Krishnamoorthy Md, Neeraj Shah Md, Babak Bozorgnia Md, Andrea Natale Md
Apixaban (factor Xa inhibitor) is a novel anticoagulant and may be beneficial during atrial fibrillation (AF) ablation for prevention of thromboembolic events. However, the adverse effects of periprocedural apixaban therapy have not been thoroughly evaluated. A meta-analysis was performed to evaluate the safety of apixaban for anticoagulation in AF ablation. We searched the online databases till October 2015 for studies comparing Apixaban with Vitamin K antagonists in atrial fibrillation patients undergoing catheter ablation...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27879314/genetic-variation-in-the-slc8a1-calcium-signaling-pathway-is-associated-with-susceptibility-to-kawasaki-disease-and-coronary-artery-abnormalities
#2
Chisato Shimizu, Hariklia Eleftherohorinou, Victoria J Wright, Jihoon Kim, Martin P Alphonse, James C Perry, Rolando Cimaz, David Burgner, Nagib Dahdah, Long T Hoang, Chiea-Chuen Khor, Andrea Salgado, Adriana H Tremoulet, Sonia Davila, Taco W Kuijpers, Martin L Hibberd, Todd A Johnson, Atsushi Takahashi, Tatsuhiko Tsunoda, Michiaki Kubo, Toshihiro Tanaka, Yoshihiro Onouchi, Rae S M Yeung, Lachlan J M Coin, Michael Levin, Jane C Burns
BACKGROUND: -Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies (GWAS) and linkage studies only partially explain the influence of genetics on KD susceptibility. METHODS AND RESULTS: -To search for additional functional genetic variation, we performed pathway and gene stability analysis on a GWAS dataset...
November 21, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27852014/the-incidence-of-pressure-ulcers-in-the-emergency-department-a-metaanalysis
#3
Peng Liu, Wang-Qin Shen, Hong-Lin Chen
OBJECTIVE: The aim of this meta-analysis was to estimate the incidence of pressure ulcers (PUs) in the emergency department (ED). METHODS: The authors searched PubMed, Web of Science, and CINAHL databases for all time leading up to February 2016. The incidence of PUs in the ED were collected, and the pooled incidence with 95% confidence interval (CI) was calculated by meta-analysis. RESULTS: Six studies with 8 cohorts were included in this study...
October 24, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27803342/subclinical-synovitis-assessed-by-ultrasound-predicts-flare-and-progressive-bone-erosion-in-rheumatoid-arthritis-patients-with-clinical-remission-a-systematic-review-and-metaanalysis
#4
Jingjing Han, Yan Geng, Xuerong Deng, Zhuoli Zhang
OBJECTIVE: Subclinical synovitis can be detected by ultrasound in patients with rheumatoid arthritis (RA) who are in clinical remission. We aimed to confirm its predictive value for flare and progressive bone erosion. METHODS: A systematic literature search was performed in Pubmed, Web of Science, Embase, and Cochrane Library on September 7, 2014. Baseline clinical and ultrasonographic characteristics were collected. Methodological quality was assessed. Pooled OR were calculated using Mantel-Haenszel model...
November 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27791099/situating-the-default-mode-network-along-a-principal-gradient-of-macroscale-cortical-organization
#5
Daniel S Margulies, Satrajit S Ghosh, Alexandros Goulas, Marcel Falkiewicz, Julia M Huntenburg, Georg Langs, Gleb Bezgin, Simon B Eickhoff, F Xavier Castellanos, Michael Petrides, Elizabeth Jefferies, Jonathan Smallwood
Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN)...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27780561/minimally-invasive-extracorporeal-circulation-circuit-is-not-inferior-to-off-pump-coronary-artery-bypass-grafting-meta-analysis-using-the-bayesian-method
#6
REVIEW
Bernhard Winkler, Paul P Heinisch, Brigitta Gahl, Soheila Aghlmandi, Hans Jörg Jenni, Thierry P Carrel
The pathophysiologic side effects of cardiopulmonary bypass have already been identified. Minimally invasive extracorporeal circulation technologies (MiECT) and off-pump coronary artery bypass graft surgery (OPCABG) aim to reduce these problems. This metaanalysis provides a comparison of MiECT and OPCABG in randomized and observational studies. A fully probabilistic, Bayesian approach of primary and secondary endpoints was conducted. MiECT does not give inferior results when compared with OPCABG. However, there is a trend to borderline significantly higher blood loss in this group in randomized controlled trials...
October 22, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27752890/hfe-genetic-variability-and-risk-of-alcoholic-liver-disease-a-meta-analysis
#7
Yan-Yan Xu, Yu-Han Tang, Xiao-Ping Guo, Jing Wang, Ping Yao
Studies examining the association of hemochromatosis (HFE) gene polymorphisms and susceptibility to alcoholic liver disease (ALD) yielded inconsistent results. Thus, we performed a metaanalysis to investigate whether the variations in HFE gene increase the risk of ALD. The studies published up to Feb. 2014 were identified by searching PubMed/MEDLINE, ISI Web of Science, EMBASE and China National Knowledge Infrastructure databases, which was complemented by screening the references of the retrieved studies. For all genotypes and alleles, the odds ratios (ORs) with 95% confidence intervals (CIs) according to the heterogeneity were pooled using fixed-effect model...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27744395/rheumatoid-arthritis-and-coronary-artery-disease-genetic-analyses-do-not-support-a-causal-relation
#8
Henning Jansen, Christina Willenborg, Wolfgang Lieb, Lingyao Zeng, Paola Gloria Ferrario, Christina Loley, Inke R König, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert
OBJECTIVE: Inflammatory diseases, specifically rheumatoid arthritis (RA), are assumed to increase the risk of coronary artery disease (CAD). More recently, multiple single-nucleotide polymorphisms (SNP) associated with RA risk were identified. If causal mechanisms affecting risks of RA and CAD are overlapping, risk alleles for RA might also increase the risk of CAD. METHODS: Sixty-one SNP associating with RA in genome-wide significant analyses were tested for association with CAD in CARDIoGRAM (Coronary ARtery DIsease Genome wide Replication and Meta-analysis), a metaanalysis including genome-wide association data (22,233 CAD cases, 64,762 controls)...
October 15, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27660570/a-metaanalysis-of-interventions-to-improve-adherence-to-lipid-lowering-medication
#9
REVIEW
Richard E Deichmann, Michael D Morledge, Robin Ulep, Johnathon P Shaffer, Philippa Davies, Mieke L van Driel
BACKGROUND: Inadequate patient adherence to a medication regimen is a major factor in the lack of success in treating hyperlipidemia. Improved adherence rates may result in significantly improved cardiovascular outcomes in populations treated with lipid-lowering therapy. The purpose of this metaanalysis was to evaluate the effectiveness of interventions aimed at improving adherence to lipid-lowering drugs, focusing on measures of adherence and clinical outcomes. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature databases through January 14, 2015, and also used the results from previous Cochrane reviews of this title...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27638204/invasive-predators-and-global-biodiversity-loss
#10
Tim S Doherty, Alistair S Glen, Dale G Nimmo, Euan G Ritchie, Chris R Dickman
Invasive species threaten biodiversity globally, and invasive mammalian predators are particularly damaging, having contributed to considerable species decline and extinction. We provide a global metaanalysis of these impacts and reveal their full extent. Invasive predators are implicated in 87 bird, 45 mammal, and 10 reptile species extinctions-58% of these groups' contemporary extinctions worldwide. These figures are likely underestimated because 23 critically endangered species that we assessed are classed as "possibly extinct...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27627219/ruminant-trans-fatty-acids-and-risk-of-breast-cancer-a-systematic-review-and-meta-analysis-of-observational-studies
#11
Roya Kolahdouz Mohammadi, Minoo Bagheri, Mina Kolahdouz Mohammadi, Farzad Shidfar
INTRODUCTION: R-TFA (ruminant trans-fatty acids) especially cis9, trans11-conjugated linoleic acid (c9,t11-CLA) and trans11-18:1 vaccenic acid (t11-18:1 VA) appear to have anticarcinogenic activity against breast cancer in animal and in vitro experiments. However, the results remain inconsistent. We therefore conducted a systematic review and meta- analysis to assess the association of c9,t11-CLA, and t11-18:1 VA (intake or serum levels) with breast cancer risk. EVIDENCE ACQUISITION: Relevant studies were identified by a search of PubMed, OVID, SCOPUS and Google scholar databases through 25 May 2015...
September 14, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27616155/diagnostic-and-clinical-utility-of-dynamic-contrast-enhanced-mr-imaging-in-indeterminate-pulmonary-nodules-a-metaanalysis
#12
Binghu Jiang, Huaijun Liu, Dan Zhou
OBJECTIVE: This study aims to perform a metaanalysis to assess the diagnostic performance and clinical utility of the dynamic magnetic resonance imaging (MRI) in discrimination of benign and malignant pulmonary nodules. MATERIALS AND METHODS: We searched PubMed, EMBASE, and Cochrane Library from January 1995 to May 2015 for studies evaluating the diagnostic accuracy of dynamic MRI in discriminating benign from malignant pulmonary nodules. Methodological quality was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2...
August 26, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27601650/men-s-status-and-reproductive-success-in-33-nonindustrial-societies-effects-of-subsistence-marriage-system-and-reproductive-strategy
#13
Christopher R von Rueden, Adrian V Jaeggi
Social status motivates much of human behavior. However, status may have been a relatively weak target of selection for much of human evolution if ancestral foragers tended to be more egalitarian. We test the "egalitarianism hypothesis" that status has a significantly smaller effect on reproductive success (RS) in foragers compared with nonforagers. We also test between alternative male reproductive strategies, in particular whether reproductive benefits of status are due to lower offspring mortality (parental investment) or increased fertility (mating effort)...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27586210/estimating-the-burden-of-weighing-less-a-systematic-review-and-meta-analysis-of-low-birth-weight-in-india
#14
Meenakshi Bhilwar, Ravi Prakash Upadhyay, Kapil Yadav, Rakesh Kumar, Palanivel Chinnakali, Smita Sinha, Shashi Kant
BACKGROUND: The National Family Health Survey-3 (NFHS- 3; 2005-06) reports that the prevalence of low birth-weight babies is 22% in India. This old figure is probably an underestimate as this nationwide survey acquired information on birth-weight of only 34% of babies. We aimed to make a fresh estimate of the proportion of low birth-weight babies. METHODS: A systematic search was done through PubMed, Google Scholar, Cochrane Library, Medline, IndMed, Embase, WHO and Biomed Central databases...
March 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/27585688/treatments-for-lupus-nephritis-a-systematic-review-and-network-metaanalysis
#15
Jasvinder A Singh, Alomgir Hossain, Ahmed Kotb, Ana Oliveira, Amy S Mudano, Jennifer Grossman, Kevin Winthrop, George A Wells
OBJECTIVE: To compare benefits and harms of lupus nephritis (LN) induction and maintenance treatments. METHODS: We performed a systematic review and Bayesian network metaanalyses of randomized controlled trials (RCT) of immunosuppressive drugs or corticosteroids (CS) in LN. OR and 95% credible intervals (CrI) were calculated. RESULTS: There were 65 RCT that met inclusion and exclusion criteria. Significantly lower risk of endstage renal disease (ESRD; 17 studies) was seen with cyclophosphamide (CYC; OR 0...
October 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27557492/foxp3-enhances-hif-1%C3%AE-target-gene-expression-in-human-bladder-cancer-through-decreasing-its-ubiquitin-proteasomal-degradation
#16
Yeong-Chin Jou, Yuh-Shyan Tsai, Chang-Te Lin, Chun-Liang Tung, Cheng-Huang Shen, Hsin-Tzu Tsai, Wen-Horng Yang, Hung-I Chang, Syue-Yi Chen, Tzong-Shin Tzai
Hypoxia-inducible factor-1α (HIF-1α) can control a transcriptional factor forkhead box P3 (Foxp3) protein expression in T lymphocyte differentiation through proteasome-mediated degradation. In this study, we unveil a reverse regulatory mechanism contributing to bladder cancer progression; Foxp3 expression attenuates HIF-1α degradation. We first demonstrated that Foxp3 expression positively correlates with the metastatic potential in T24 cells and can increase the expression of HIF-1α-target genes, such as vascular endothelial growth factor (VEGF) and glucose transporter (GLUT)...
August 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27508705/-op-4b-10-left-ventricular-mass-after-renal-transplantation-metaanalysis-of-cross-sectional-and-longitudinal-studies
#17
B Schmidt, K Bergmann, J Kaufeld, A Melk
OBJECTIVE: Left ventriuclar mass (LVM) is a strong predictor of cardiovascular events. In patients with chronic kidney disease and in patients on dialysis left ventricular hypertrophy is highly prevalent. Overcoming uremia by renal transplantation might improve LVM. However, after transplantation treatment with steroids and calcineurin inhibitors increases blood pressure and therefore might counteract the positive effect of restoring renal function.We performed a metaanalysis of the available evidence from observational studies in patientts after renal tranplantation...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27504058/the-epidemiology-of-thoracolumbar-trauma-a-meta-analysis
#18
Yoshihiro Katsuura, James Michael Osborn, Garrick Wayne Cason
PURPOSE: To describe the epidemiology of thoracolumbar fractures and associated injuries in blunt trauma patients. METHODS: A systematic review and metaanalysis was performed based on a MEDLINE database search using MeSH terms for studies matching our inclusion criteria. The search yielded 21 full-length articles, each sub-grouped according to content. Data extraction and multiple analyses were performed on descriptive data. RESULTS: The rate of thoracolumbar fracture in blunt trauma patients was 6...
December 2016: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27494723/therapeutic-efficacy-of-pcsk9-monoclonal-antibodies-in-statin-nonresponsive-patients-with-hypercholesterolemia-and-dyslipidemia-a-systematic-review-and-meta-analysis
#19
REVIEW
Wan Peng, Fu Qiang, Wei Peng, Zhang Qian, Zhu Ke, Lu Yi, Zhong Jian, Qiu Chongrong
BACKGROUND AND OBJECTIVE: Heterozygous familial hypercholesterolemia and dyslipidemia are the predominant causes for cardiovascular disease (CVD). Clinical guidelines for lowering CVD risk have advocated that low density lipoprotein-cholesterol (LDL-C) must be reduced. The primary choice of therapy for controlling lipidemia has been statins, which are not completely effective. Proprotein convertase subtilisin/kexin type-9 (PCSK9), which interferes with LDL clearance from circulation, inversely relates to the LDL-C levels...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27489049/efficacy-and-safety-of-doublet-versus-single-agent-as-salvage-treatment-for-metastatic-breast-cancer-pretreated-with-anthracyclines-and-taxanes-a-systematic-review-and-meta-analysis
#20
Tengteng Zhang, Ruoming Wang, Yunbin Liu, Jisheng Huang, Zhen Yang
AIM: To perform a systematic review and meta-analysis of randomized controlled trials to compare the efficacy and safety of doublet versus single agent as salvage treatment for pretreated metastatic breast cancer. METHODS: A comprehensive literature search was performed to identify relevant randomized controlled trials (RCTs). All clinical studies were independently identified by two authors for inclusion. Demographic data, treatment regimens, objective response rate (ORR), and progression-free survival (PFS) and overall survival (OS) were extracted and analyzed using Comprehensive MetaAnalysis software (Version 2...
November 2016: Current Medical Research and Opinion
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