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https://www.readbyqxmd.com/read/29230120/the-relationship-between-regional-anesthesia-and-cancer-a-metaanalysis
#1
REVIEW
Ravi K Grandhi, Samuel Lee, Alaa Abd-Elsayed
Background: Some studies have suggested using epidural analgesia after cancer surgery to reduce metastasis. This article examines the relationship between regional anesthesia (RA) and cancer metastasis in an array of cancers. Methods: We conducted a review of the literature using PubMed and included 67,577 patients across 28 studies in a metaanalysis, evaluating the hazard ratios (HRs) of overall survival, recurrence-free survival, and biochemical recurrence-free survival...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29222339/the-biological-variation-data-critical-appraisal-checklist-a-standard-for-evaluating-studies-on-biological-variation
#2
Aasne K Aarsand, Thomas R Raas, Pilar Fernandez-Calle, Carmen Ricos, Jorge Díaz-Garzón, Niels Jonker, Carmen Perich, Elisabet González-Lao, Anna Carobene, Joana Minchinela, Abdurrahman Coŝkun, Margarita Simón, Virtudes Álvarez, William A Bartlett, Pilar Fernández-Fernández, Beatriz Boned, Federica Braga, Zoraida Corte, Berna Aslan, Sverre Sandberg
BACKGROUND: Concern has been raised about the quality of available biological variation (BV) estimates and the effect of their application in clinical practice. A European Federation of Clinical Chemistry and Laboratory Medicine Task and Finish Group has addressed this issue. The aim of this report is to (a) describe the Biological Variation Data Critical Appraisal Checklist (BIVAC), which verifies whether publications have included all essential elements that may impact the veracity of associated BV estimates, (b) use the BIVAC to critically appraise existing BV publications on enzymes, lipids, kidney, and diabetes-related measurands, and (c) apply metaanalysis to deliver a global within-subject BV (CVI) estimate for alanine aminotransferase (ALT)...
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29208719/effect-of-removing-kupffer-cells-on-nanoparticle-tumor-delivery
#3
Anthony J Tavares, Wilson Poon, Yi-Nan Zhang, Qin Dai, Rickvinder Besla, Ding Ding, Ben Ouyang, Angela Li, Juan Chen, Gang Zheng, Clinton Robbins, Warren C W Chan
A recent metaanalysis shows that 0.7% of nanoparticles are delivered to solid tumors. This low delivery efficiency has major implications in the translation of cancer nanomedicines, as most of the nanomedicines are sequestered by nontumor cells. To improve the delivery efficiency, there is a need to investigate the quantitative contribution of each organ in blocking the transport of nanoparticles to solid tumors. Here, we hypothesize that the removal of the liver macrophages, cells that have been reported to take up the largest amount of circulating nanoparticles, would lead to a significant increase in the nanoparticle delivery efficiency to solid tumors...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29202925/the-investigation-of-suspected-fracture-a-comparison-of-ultrasound-with-conventional-imaging
#4
Gordian Lukas Schmid, Stefan Lippmann, Susanne Unverzagt, Christiane Hofmann, Tobias Deutsch, Thomas Frese
BACKGROUND: Ultrasound imaging can be used to diagnose fractures in patients with acute trauma. Its main advantages over conventional imaging are the absence of radiation exposure and its greater availability. METHODS: A systematic search in electronic databases (Medline, Embase, Cochrane CENTRAL) was supplemented by a manual search on the Internet and in the reference lists of pertinent publications. The QUADAS-2 instrument was used to assess the quality of the individual studies retrieved...
November 10, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29199666/metformin-use-and-survival-of-lung-cancer-patients-meta-analysis-findings
#5
REVIEW
S Zhong, Y Wu, X Yan, J Tang, J Zhao
Previous studies on the association between metformin use and lung cancer survival have yielded mixed results. We aimed to perform a metaanalysis to assess the association with all available studies. Relevant studies were identified by searching PubMed and EMBASE to July 2016. We calculated the summary hazard ratios (HRs) and 95% confidence intervals (CIs) using randomeffects models. Twelve cohort studies involving 124,533 participants were included in this study. The results showed that metformin use was not associated with the overall survival of lung cancer patients (HR = 0...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199661/related-factors-of-postoperative-gallstone-formation-after-distal-gastrectomy-a-meta-analysis
#6
REVIEW
Y Chen, Y Li
AIM: The aim of this study was to evaluate the risk factor of gallstone occurrence after distal gastrectomy (DG) for gastric cancer. METHODS: Relevant documents published from 2000 to 2016 were retrieved in PubMed, Web of Knowledge, and Ovid's database, and a metaanalysis was performed with RevMan 5.0 software for odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Eight studies met the final inclusion criteria. From the pooled analyses, nonphysiological reconstruction (OR = 1...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29193261/metaanalysis-of-mood-and-substance-use-disorders-in-proximal-risk-for-suicide-deaths
#7
Kenneth R Conner, Jeffrey A Bridge, Dustin J Davidson, Carly Pilcher, David A Brent
Evidence for proximal risk factors for suicide is based on case-control psychological autopsy studies, with these reports showing that mood and substance use disorders are the most prevalent mental disorders among suicide decedents worldwide and are associated with marked risk. However, moderators of risk and the degree of risk associated with (nonalcohol) drug use disorder are unknown. A comprehensive search was used to identify 35 case-control psychological autopsy studies published worldwide over a 30-year period that were metaanalyzed using random effects models...
November 28, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29181731/sodium-tanshinone-ii-a-sulfonate-injection-as-adjuvant-treatment-for-unstable-angina-pectoris-a-meta-analysis-of-17-randomized-controlled-trials
#8
Di Tan, Jia-Rui Wu, Xiao-Meng Zhang, Shi Liu, Bing Zhang
OBJECTIVE: To systematically evaluate the effectiveness and safety of Sodium Tanshinone II A Sulfonate Injection (STS) as one adjuvant therapy for treating unstable angina pectoris (UAP). METHODS: Randomized controlled trials (RCTs) of UAP treated by STS were searched in the China National Knowledge Infrastructure Database (CNKI), VIP Database for Chinese Technical Periodicals (VIP), Wanfang Database, the Chinese Biomedical Literature Database (CBM), Web of Science, the Cochrane Library, Embase, and PubMed, which from inception to January, 2016...
November 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29178871/efficacy-and-safety-of-tiotropium-and-olodaterol-in-copd-a-systematic-review-and-meta-analysis
#9
Marc Miravitlles, Gerard Urrutia, Alexander G Mathioudakis, Julio Ancochea
BACKGROUND: Long-acting bronchodilators are the cornerstone of pharmacologic treatment of COPD. The new combination of long-acting muscarinic antagonist (LAMA) tiotropium (TIO) and long acting beta-agonists (LABA) olodaterol (OLO) has been introduced as fist line therapy for COPD. This article analyses the evidence of efficacy and safety of the TIO/OLO combination. METHODS: A systematic review and metaanalysis of randomized controlled trials (RCT) with a period of treatment of at least 6 weeks, in patients with COPD confirmed by spirometry, comparing combined treatment with TIO/OLO (approved doses only), with any of the mono-components or any other active comparator administered as an inhalator...
November 25, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29175805/review-autologous-blood-transfusion-drainage-compared-with-no-drainage-in-total-knee-arthroplasty-a-meta-analysis-and-systematic-review
#10
Kun-Hao Hong, Jian-Ke Pan, Hui Xie, Da Guo, Wei-Yi Yang, Hai-Tao Su, Shu-Chai Xu, Jun Liu
This is the first meta-analysis to assess the clinical efficiency, safety and potential advantages regarding the use of ABT drains compared with no drainage which is controversial in total knee arthroplasty (TKA).A comprehensive literature search was carried out in March 2015 using the PubMed, Embase, and Cochrane Library databases. A metaanalysis was carried out on two retrospective comparative studies (RCSs) and five randomized controlled trials (RCTs). The number of patients receiving homologous blood transfusion was the primary outcome of the meta-analysis; the secondary outcome measure was the mean drop in Hb level in comparison to the mean pre-operative HB level, the range of flexion of the knee joint, and infections of the wound after surgery...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29159840/cognitive-outcomes-after-transcatheter-aortic-valve-implantation-a-metaanalysis
#11
Maisha M Khan, Nathan Herrmann, Damien Gallagher, Dov Gandell, Stephen E Fremes, Harindra C Wijeysundera, Sam Radhakrishnan, Yue Ran Sun, Krista L Lanctôt
OBJECTIVES: To quantitatively summarize changes in cognitive performance in individuals with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). DESIGN: Metaanalysis. PARTICIPANTS: Individuals undergoing TAVI (N = 1,065 (48.5% male) from 18 studies, average age ≥80). MEASUREMENTS: The MEDLINE, EMBASE, and Cochrane Central databases were searched for original peer-reviewed reports assessing cognitive performance using standardized cognitive tests before and after TAVI...
November 21, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29131306/comparative-effectiveness-and-safety-of-cognitive-enhancers-for-treating-alzheimer-s-disease-systematic-review-and-network-metaanalysis
#12
Andrea C Tricco, Huda M Ashoor, Charlene Soobiah, Patricia Rios, Areti Angeliki Veroniki, Jemila S Hamid, John D Ivory, Paul A Khan, Fatemeh Yazdi, Marco Ghassemi, Erik Blondal, Joanne M Ho, Carmen H Ng, Brenda Hemmelgarn, Sumit R Majumdar, Laure Perrier, Sharon E Straus
BACKGROUND/OBJECTIVES: To examine the comparative effectiveness and safety of cognitive enhancers for Alzheimer's disease (AD). DESIGN: Systematic review and Bayesian network metaanalysis (NMA). SETTING: MEDLINE, EMBASE, Cochrane Library, CINAHL, Ageline (inception-March 2016). PARTICIPANTS: Individuals with AD in randomized controlled trials (RCTs), quasi-RCTs, and nonrandomized studies. INTERVENTION: Any combination of donepezil, rivastigmine, galantamine, or memantine...
September 29, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29071719/medications-that-cause-dry-mouth-as-an-adverse-effect-in-older-people-a-systematic-review-and-metaanalysis
#13
Edwin Ck Tan, Duangjai Lexomboon, Gunilla Sandborgh-Englund, Ylva Haasum, Kristina Johnell
OBJECTIVES: To assess and quantify the risk of drug-induced dry mouth as a side effect in older people. DESIGN: Systematic review and metaanalysis. SETTING: A search of the literature was undertaken using Medline, Embase, Cochrane, Web of Science, and PubMed from 1990 to 2016. PARTICIPANTS: Older people (aged ≥60) who participated in intervention or observational studies investigating drug use as an exposure and xerostomia or salivary gland hypofunction as adverse drug outcomes...
October 26, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29046330/systematic-review-and-metaanalysis-comparing-the-bias-and-accuracy-of-the-modification-of-diet-in-renal-disease-and-chronic-kidney-disease-epidemiology-collaboration-equations-in-community-based-populations
#14
REVIEW
Emily C McFadden, Jennifer A Hirst, Jan Y Verbakel, Julie H McLellan J, F D Richard Hobbs, Richard J Stevens, Chris A O'Callaghan, Daniel S Lasserson
BACKGROUND: The majority of patients with chronic kidney disease are diagnosed and monitored in primary care. Glomerular filtration rate (GFR) is a key marker of renal function, but direct measurement is invasive; in routine practice, equations are used for estimated GFR (eGFR) from serum creatinine. We systematically assessed bias and accuracy of commonly used eGFR equations in populations relevant to primary care. CONTENT: MEDLINE, EMBASE, and the Cochrane Library were searched for studies comparing measured GFR (mGFR) with eGFR in adult populations comparable to primary care and reporting both the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations based on standardized creatinine measurements...
October 18, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28991368/predicting-discharge-to-institutional-long-term-care-after-stroke-a-systematic-review-and-metaanalysis
#15
Jennifer K Burton, Eilidh E C Ferguson, Amanda J Barugh, Katherine E Walesby, Alasdair M J MacLullich, Susan D Shenkin, Terry J Quinn
BACKGROUND/OBJECTIVES: Stroke is a leading cause of disability worldwide, and a significant proportion of stroke survivors require long-term institutional care. Understanding who cannot be discharged home is important for health and social care planning. Our aim was to establish predictive factors for discharge to institutional care after hospitalization for stroke. DESIGN: We registered and conducted a systematic review and meta-analysis (PROSPERO: CRD42015023497) of observational studies...
October 9, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28984764/a-systematic-review-and-meta-analysis-of-the-prevalence-of-norovirus-in-cases-of-gastroenteritis-in-developing-countries
#16
REVIEW
Gia Thanh Nguyen, Kevin Phan, Ian Teng, Jian Pu, Toru Watanabe
BACKGROUND: While norovirus (NoV) is well known as a leading causal pathogen for acute gastroenteritis in developed countries,structured data on prevalence in developing countries are not available thus far. This review aims to estimate the prevalence of NoV in cases of gastroenteritis in developing countries based on recently published reports. METHODS: Relevant studies were identified by searching PubMed and Web of Science for the period January 1, 1990 through March 31, 2016...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28955668/assessing-abstracts-of-iranian-systematic-reviews-and-metaanalysis-indexed-in-wos-and-scopus-using-prisma
#17
Maryam Kazerani, Atefeh Davoudian, Farid Zayeri, Hamid Soori
Background: Systematic reviews and meta-analysis have significant advantages over conventional reviews in that all available data should be presented. This study aimed to evaluate Iranian systematic reviews and meta-analysis abstracts indexed in WOS and Scopus during 2003-2012 based on PRISMA checklist. Methods: This is an analytical study. We evaluated 46 article abstracts indexed in WOS, 89 article abstracts indexed in Scopus and 158 article abstracts indexed in WOS and Scopus both (overlapped group). The quality of the abstracts was evaluated according to the PRISMA checklist for abstracts...
2017: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/28938690/p-akt-as-a-potential-poor-prognostic-factor-for-gastric-cancer-a-systematic-review-and-meta-analysis
#18
REVIEW
Fang Cao, Cong Zhang, Wei Han, Xiao-Jiao Gao, Jun Ma, Yong-Wei Hu, Xing Gu, Hou-Zhong Ding, Li-Xia Zhu, Qin Liu
To understand the relationship between p-Akt expression and the prognosis of patients with gastric cancer, we searched six databases, Pubmed, EMBASE, Cochrane Library, CNKI, Wanfang and CBM for relevant articles in order to conduct this metaanalysis. The pooled hazard ratios and corresponding 95%CI of overall survival were calculated to evaluate the prognostic value of p-Akt expression in patients with gastric cancer. With 2261 patients combined from 13 available studies, the pooled HR showed a poor prognosis in patients with gastric cancer in the univariate analysis (HR=1...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28920562/comparison-of-general-and-local-anesthesia-for-deep-brain-stimulator-insertion-a-systematic-review
#19
Veena Sheshadri, Nathan C Rowland, Jigesh Mehta, Marina Englesakis, Pirjo Manninen, Lashmi Venkatraghavan
BACKGROUND: Subthalamic nucleus deep brain stimulation (STN-DBS) has become a standard treatment for many patients with Parkinson's disease (PD). The reported clinical outcome measures for procedures done under general anesthesia (GA) compared to traditional local anesthetic (LA) technique are quite heterogeneous and difficult to compare. The aim of this systematic review and metaanalysis was to determine whether the clinical outcome after STN-DBS insertion under GA is comparable to that under LA in patients with Parkinson's disease...
September 18, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28916551/genetic-determinants-of-radiographic-knee-osteoarthritis-in-african-americans
#20
Youfang Liu, Michelle S Yau, Laura M Yerges-Armstrong, David J Duggan, Jordan B Renner, Marc C Hochberg, Braxton D Mitchell, Rebecca D Jackson, Joanne M Jordan
OBJECTIVE: The etiology of knee osteoarthritis (OA), the most common form of arthritis, is complex and may differ by race or ethnicity. In recent years, genetic studies have identified many genetic variants associated with OA, but nearly all the studies were conducted in European whites and Asian Americans. Few studies have focused on the genetics of knee OA in African Americans. METHODS: We performed a genome-wide association study of radiographic knee OA in 1217 African Americans from 2 North American cohort studies: 590 subjects from the Johnston County Osteoarthritis Project and 627 subjects from the Osteoarthritis Initiative...
November 2017: Journal of Rheumatology
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