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https://www.readbyqxmd.com/read/29439921/impact-of-organizational-interventions-on-reducing-inappropriate-intravenous-immunoglobulin-ivig-usage-a-systematic-review-and-meta-analysis
#1
Calvin Diep, Andrew W Shih, Erin Jamula, Nancy M Heddle, Michael Parvizian, Christopher M Hillis
BACKGROUND: With increasing global use of intravenous immunoglobulin (IVIG), there is interest in its appropriate usage. Efforts to regulate IVIG usage have primarily taken the form of organizational interventions implemented in hospitals to monitor and improve physician prescribing. Similar interventions have proven effective in reducing the inappropriate and total hospital usage of other blood products, but their efficacy on IVIG use is less understood. Thus, we performed a systematic review of studies reporting the change in inappropriate IVIG use following such interventions in hospitals or regions...
January 31, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29401273/low-risk-of-primary-clostridium-difficile-infection-with-tetracyclines-a-systematic-review-and-metaanalysis
#2
Raseen Tariq, Janice Cho, Saloni Kapoor, Robert Orenstein, Siddharth Singh, Darrell S Pardi, Sahil Khanna
Background: The choice of antibiotics for systemic infections in patients with a high risk of Clostridium difficile infection (CDI) remains a clinical practice dilemma. Although some studies suggest that tetracyclines may be associated with a lower risk of CDI than other antibiotics, other results are conflicting. We conducted a systematic review and metaanalysis of studies that assessed the risk of CDI with tetracyclines compared to other antibiotics. Methods: We conducted a systematic search of Medline, Embase, and Web of Science from January 1978 through December 2016 to include studies that assessed the association between tetracycline use and risk of CDI...
February 1, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29397134/systematic-review-of-the-qor-15-score-a-patient-reported-outcome-measure-measuring-quality-of-recovery-after-surgery-and-anaesthesia
#3
REVIEW
J Kleif, J Waage, K B Christensen, I Gögenur
BACKGROUND: The QoR-15 is a patient-reported outcome questionnaire that measures the quality of recovery after surgery and anaesthesia. We aimed to perform a systematic review and meta-analysis of the measurement properties of the QoR-15. METHODS: Studies reporting measurement properties or interpretability of the QoR-15 after surgery were eligible for inclusion. All languages were included in the PubMed and Embase search. The COSMIN guidelines for systematic reviews of patient-reported outcome measurements were followed...
January 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29394213/eosinophil-counts-in-the-small-intestine-and-colon-of-children-without-apparent-gastrointestinal-disease-a-meta-analysis
#4
Zoltán Kiss, Bálint Tél, Nelli Farkas, András Garami, Áron Vincze, Judit Bajor, Patrícia Sarlós, Katalin Márta, Adrienn Erős, Alexandra Mikó, Zsolt Szakács, Dániel Pécsi, Péter Mátrai, Péter Hegyi, Gábor Veres
OBJECTIVES: The aim of the current study was to review the available data regarding eosinophil density in healthy tissue specimen originating from lower gastrointestinal segments to support suggested diagnostic cut-offs widely used in clinical practice. METHODS: A systematic search was performed in three different databases. Calculations were made with Comprehensive MetaAnalysis software using random effects model. Cell number measurements were pooled using the random effects model and displayed on forest plots...
February 1, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29385792/efficacy-of-micronized-purified-flavonoid-fraction-daflon%C3%A2-on-improving-individual-symptoms-signs-and-quality-of-life-in-patients-with-chronic-venous-disease-a-systematic-review-and-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#5
Stavros Kakkos, Andrew Nicolaides
INTRODUCTION: The use of a venoactive drug is considered an important component of medical treatment of chronic venous disease (CVD), although the efficacy of certain VADs on one or more individual leg symptoms or signs may have not been extensively studied to justify a strong recommendation in guidelines on CVD. The aim of this systematic review and metaanalysis was to study the effectiveness of the micronized purified flavonoid fraction (MPFF, Daflon®) across the spectrum of defined venous symptoms, signs, quality of life (QoL) and treatment assessment by the physician...
January 31, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29382025/wendan-decoction-for-primary-insomnia-protocol-for-a-systematic-review-and-meta-analysis
#6
Xia Yan, Yuanping Wang, Xiaohui Li, Ziqin Li, Yu Zhang, Xiaoli Cai, Dawei Wang
BACKGROUND: Insomnia is a widespread complaint in the general population. Wendan decoction has been widely applied in the treatment of primary insomnia. However, to our knowledge, there has been no systematic review or meta-analysis of randomized controlled trails regarding the effectiveness of this treatment. Here, we provide a protocol to evaluate the efficacy and safety of Wendan decoction for primary insomnia. METHODS AND ANALYSIS: Relevant randomized controlled trials in 5 English databases [EMBASE, the Cochrane Central Register of Controlled Trials (Cochrane Library), PubMed, the Allied and Complementary Medicine Databases (AMED), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL)], 4 Chinese databases [Chinese Biomedical Literature Database (CBM), Chinese Medical Current Content (CMCC), China National Knowledge Infrastructure (CNKI), and Wanfang Database] will be comprehensively searched by 2 researchers in October 2017...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29335342/comparative-efficacy-of-tumor-necrosis-factor-%C3%AE-inhibitors-in-ankylosing-spondylitis-a-systematic-review-and-bayesian-network-metaanalysis
#7
Runsheng Wang, Abhijit Dasgupta, Michael M Ward
OBJECTIVE: To compare the efficacy of 6 tumor necrosis factor-α inhibitors (TNFi) in treatment of ankylosing spondylitis (AS) at 12 weeks and 24 weeks. METHODS: We performed a systematic literature review of randomized controlled trials of TNFi in patients with active AS. We included trials that reported efficacy at 10 to 14 weeks (12-week analysis) and at 24 to 30 weeks (24-week analysis). We used Bayesian network metaanalysis (NMA) to compare their relative efficacy to improve the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and C-reactive protein (CRP) level...
January 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29332348/sorafenib-combined-with-radiofrequency-ablation-as-treatment-for-patients-with-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#8
Lin Chen, Xingming Ma, Xin Liu, Xiaomeng Cui
PURPOSE: To evaluate the safety and efficacy of a combination of sorafenib and radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC). METHODS: A systematic literature search was conducted using PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBMdisc), WanFang Database, for all years up to January 2017. Pooled analyses of overall survival (OS), tumor- free survival, recurrence rates and adverse events were performed...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29284392/mrp4-abcc4-as-a-new-therapeutic-target-meta-analysis-to-determine-camp-binding-sites-as-a-tool-for-drug-design
#9
Agustín Yaneff, Ana Sahores, Natalia Gomez, Alejandro Carozzo, Carina Shayo, Carlos Davio
MRP4 transports multiple endogenous and exogenous substances and is critical not only for detoxification but also in the homeostasis of several signaling molecules. Its dysregulation has been reported in numerous pathological disorders, thus MRP4 appears as an attractive therapeutic target. However, the efficacy of MRP4 inhibitors is still controversial. The design of specific pharmacological agents with the ability to selectively modulate the activity of this transporter or modify its affinity to certain substrates represents a challenge in current medicine and chemical biology...
December 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29277096/an-overview-of-meta-analysis-for-clinicians
#10
Young Ho Lee
The number of medical studies being published is increasing exponentially, and clinicians must routinely process large amounts of new information. Moreover, the results of individual studies are often insufficient to provide confident answers, as their results are not consistently reproducible. A meta-analysis is a statistical method for combining the results of different studies on the same topic and it may resolve conflicts among studies. Meta-analysis is being used increasingly and plays an important role in medical research...
December 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29230120/the-relationship-between-regional-anesthesia-and-cancer-a-metaanalysis
#11
REVIEW
Ravi K Grandhi, Samuel Lee, Alaa Abd-Elsayed
Background: Some studies have suggested using epidural analgesia after cancer surgery to reduce metastasis. This article examines the relationship between regional anesthesia (RA) and cancer metastasis in an array of cancers. Methods: We conducted a review of the literature using PubMed and included 67,577 patients across 28 studies in a metaanalysis, evaluating the hazard ratios (HRs) of overall survival, recurrence-free survival, and biochemical recurrence-free survival...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29222339/the-biological-variation-data-critical-appraisal-checklist-a-standard-for-evaluating-studies-on-biological-variation
#12
Aasne K Aarsand, Thomas R Raas, Pilar Fernandez-Calle, Carmen Ricos, Jorge Díaz-Garzón, Niels Jonker, Carmen Perich, Elisabet González-Lao, Anna Carobene, Joana Minchinela, Abdurrahman Coŝkun, Margarita Simón, Virtudes Álvarez, William A Bartlett, Pilar Fernández-Fernández, Beatriz Boned, Federica Braga, Zoraida Corte, Berna Aslan, Sverre Sandberg
BACKGROUND: Concern has been raised about the quality of available biological variation (BV) estimates and the effect of their application in clinical practice. A European Federation of Clinical Chemistry and Laboratory Medicine Task and Finish Group has addressed this issue. The aim of this report is to (a) describe the Biological Variation Data Critical Appraisal Checklist (BIVAC), which verifies whether publications have included all essential elements that may impact the veracity of associated BV estimates, (b) use the BIVAC to critically appraise existing BV publications on enzymes, lipids, kidney, and diabetes-related measurands, and (c) apply metaanalysis to deliver a global within-subject BV (CVI) estimate for alanine aminotransferase (ALT)...
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29208719/effect-of-removing-kupffer-cells-on-nanoparticle-tumor-delivery
#13
Anthony J Tavares, Wilson Poon, Yi-Nan Zhang, Qin Dai, Rickvinder Besla, Ding Ding, Ben Ouyang, Angela Li, Juan Chen, Gang Zheng, Clinton Robbins, Warren C W Chan
A recent metaanalysis shows that 0.7% of nanoparticles are delivered to solid tumors. This low delivery efficiency has major implications in the translation of cancer nanomedicines, as most of the nanomedicines are sequestered by nontumor cells. To improve the delivery efficiency, there is a need to investigate the quantitative contribution of each organ in blocking the transport of nanoparticles to solid tumors. Here, we hypothesize that the removal of the liver macrophages, cells that have been reported to take up the largest amount of circulating nanoparticles, would lead to a significant increase in the nanoparticle delivery efficiency to solid tumors...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29202925/the-investigation-of-suspected-fracture-a-comparison-of-ultrasound-with-conventional-imaging
#14
Gordian Lukas Schmid, Stefan Lippmann, Susanne Unverzagt, Christiane Hofmann, Tobias Deutsch, Thomas Frese
BACKGROUND: Ultrasound imaging can be used to diagnose fractures in patients with acute trauma. Its main advantages over conventional imaging are the absence of radiation exposure and its greater availability. METHODS: A systematic search in electronic databases (Medline, Embase, Cochrane CENTRAL) was supplemented by a manual search on the Internet and in the reference lists of pertinent publications. The QUADAS-2 instrument was used to assess the quality of the individual studies retrieved...
November 10, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29199666/metformin-use-and-survival-of-lung-cancer-patients-meta-analysis-findings
#15
REVIEW
S Zhong, Y Wu, X Yan, J Tang, J Zhao
Previous studies on the association between metformin use and lung cancer survival have yielded mixed results. We aimed to perform a metaanalysis to assess the association with all available studies. Relevant studies were identified by searching PubMed and EMBASE to July 2016. We calculated the summary hazard ratios (HRs) and 95% confidence intervals (CIs) using randomeffects models. Twelve cohort studies involving 124,533 participants were included in this study. The results showed that metformin use was not associated with the overall survival of lung cancer patients (HR = 0...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199661/related-factors-of-postoperative-gallstone-formation-after-distal-gastrectomy-a-meta-analysis
#16
REVIEW
Y Chen, Y Li
AIM: The aim of this study was to evaluate the risk factor of gallstone occurrence after distal gastrectomy (DG) for gastric cancer. METHODS: Relevant documents published from 2000 to 2016 were retrieved in PubMed, Web of Knowledge, and Ovid's database, and a metaanalysis was performed with RevMan 5.0 software for odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Eight studies met the final inclusion criteria. From the pooled analyses, nonphysiological reconstruction (OR = 1...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29193261/metaanalysis-of-mood-and-substance-use-disorders-in-proximal-risk-for-suicide-deaths
#17
Kenneth R Conner, Jeffrey A Bridge, Dustin J Davidson, Carly Pilcher, David A Brent
Evidence for proximal risk factors for suicide is based on case-control psychological autopsy studies, with these reports showing that mood and substance use disorders are the most prevalent mental disorders among suicide decedents worldwide and are associated with marked risk. However, moderators of risk and the degree of risk associated with (nonalcohol) drug use disorder are unknown. A comprehensive search was used to identify 35 case-control psychological autopsy studies published worldwide over a 30-year period that were metaanalyzed using random effects models...
November 28, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29181731/sodium-tanshinone-ii-a-sulfonate-injection-as-adjuvant-treatment-for-unstable-angina-pectoris-a-meta-analysis-of-17-randomized-controlled-trials
#18
Di Tan, Jia-Rui Wu, Xiao-Meng Zhang, Shi Liu, Bing Zhang
OBJECTIVE: To systematically evaluate the effectiveness and safety of Sodium Tanshinone II A Sulfonate Injection (STS) as one adjuvant therapy for treating unstable angina pectoris (UAP). METHODS: Randomized controlled trials (RCTs) of UAP treated by STS were searched in the China National Knowledge Infrastructure Database (CNKI), VIP Database for Chinese Technical Periodicals (VIP), Wanfang Database, the Chinese Biomedical Literature Database (CBM), Web of Science, the Cochrane Library, Embase, and PubMed, which from inception to January, 2016...
November 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29178871/efficacy-and-safety-of-tiotropium-and-olodaterol-in-copd-a-systematic-review-and-meta-analysis
#19
Marc Miravitlles, Gerard Urrutia, Alexander G Mathioudakis, Julio Ancochea
BACKGROUND: Long-acting bronchodilators are the cornerstone of pharmacologic treatment of COPD. The new combination of long-acting muscarinic antagonist (LAMA) tiotropium (TIO) and long acting beta-agonists (LABA) olodaterol (OLO) has been introduced as fist line therapy for COPD. This article analyses the evidence of efficacy and safety of the TIO/OLO combination. METHODS: A systematic review and metaanalysis of randomized controlled trials (RCT) with a period of treatment of at least 6 weeks, in patients with COPD confirmed by spirometry, comparing combined treatment with TIO/OLO (approved doses only), with any of the mono-components or any other active comparator administered as an inhalator...
November 25, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29175805/review-autologous-blood-transfusion-drainage-compared-with-no-drainage-in-total-knee-arthroplasty-a-meta-analysis-and-systematic-review
#20
Kun-Hao Hong, Jian-Ke Pan, Hui Xie, Da Guo, Wei-Yi Yang, Hai-Tao Su, Shu-Chai Xu, Jun Liu
This is the first meta-analysis to assess the clinical efficiency, safety and potential advantages regarding the use of ABT drains compared with no drainage which is controversial in total knee arthroplasty (TKA).A comprehensive literature search was carried out in March 2015 using the PubMed, Embase, and Cochrane Library databases. A metaanalysis was carried out on two retrospective comparative studies (RCSs) and five randomized controlled trials (RCTs). The number of patients receiving homologous blood transfusion was the primary outcome of the meta-analysis; the secondary outcome measure was the mean drop in Hb level in comparison to the mean pre-operative HB level, the range of flexion of the knee joint, and infections of the wound after surgery...
November 2017: Pakistan Journal of Pharmaceutical Sciences
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