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https://www.readbyqxmd.com/read/28105131/immunoglobulin-g4-related-acquired-hemophilia-a-case-report
#1
Xiaoyan Li, Wei Duan, Xiang Zhu, Jianying Xu
Acquired hemophilia A (AHA) is a relatively rare and life-threatening bleeding disorder whose pathogenesis is not completely understood. The present study reports a rare case of immunogubulin (IgG)4-related AHA with multisystemic involvement. A 55-year old male patient presented with symptoms of bronchial asthma and multiple subdermal hematomas. Chest computed tomography showed multiple diffuse nodular lesions with thickening of bronchovascular bundles, and scattered high-density spots in both lung lobes. Laboratory investigations showed increased activated partial prothrombin time (120...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104718/boncat-enables-time-resolved-analysis-of-protein-synthesis-in-native-plant-tissue
#2
Weslee Glenn, Shannon E Stone, Samuel H Ho, Michael J Sweredoski, Annie Moradian, Sonja Hess, Julia Bailey-Serres, David A Tirrell
Proteomic plasticity undergirds stress responses in plants, and understanding such responses requires accurate measurement of the extent to which proteins levels are adjusted to counter external stimuli. Here, we adapt bioorthogonal non-canonical amino acid tagging (BONCAT) to interrogate protein synthesis in vegetative Arabidopsis thaliana seedlings. BONCAT relies on the translational incorporation of a non-canonical amino acid (ncAA) probe into cellular proteins. In this study, the probe is the methionine surrogate azidohomoalanine (Aha), which carries a reactive azide moiety in its amino acid side chain...
January 19, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28104481/identification-of-the-potentially-arrhythmogenic-substrate-in-the-acute-phase-of-st-elevation-myocardial-infarction
#3
Diego Penela, Juan Acosta, David Andreu, Jose T Ortiz, Xavier Bosch, Rosario J Perea, Teresa M de Caralt, Juan Fernández-Armenta, David Soto, Susana Prat, Roger Borràs, Lluis Mont, Vanessa Hervas, Manuel Morales, Wladimiro Jiménez, Aurea Mira, Jim Donnelly, Okan Ekinci, Luis Lasalvia, Antonio Berruezo
BACKGROUND: Predicting sudden cardiac death risk in the first months after ST-segment elevation myocardial infarction (STEMI) remains challenging. OBJECTIVE: To investigate late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) capacity to identify the potentially arrhythmogenic substrate and its temporal evolution after a STEMI. METHODS: One hundred consecutive patients with a first STEMI were included. A 3D high-resolution LGE-CMR was obtained at 3T at day 7 and 180...
January 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28096704/neonatal-resuscitation-advances-in-training-and-practice
#4
REVIEW
Taylor Sawyer, Rachel A Umoren, Megan M Gray
Each year in the US, some four hundred thousand newborns need help breathing when they are born. Due to the frequent need for resuscitation at birth, it is vital to have evidence-based care guidelines and to provide effective neonatal resuscitation training. Every five years, the International Liaison Committee on Resuscitation (ILCOR) reviews the science of neonatal resuscitation. In the US, the American Heart Association (AHA) develops treatment guidelines based on the ILCOR science review, and the Neonatal Resuscitation Program (NRP) translates the AHA guidelines into an educational curriculum...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28092931/the-criteria-of-metabolic-syndrome-and-national-health-checkup-and-education-system-in-japan
#5
Kazumasa Yamagishi, Hiroyasu Iso
Two major definitions of metabolic syndrome have been proposed. One focuses on accumulation of risk factors such as the American Heart Association (AHA) and National Heart, Lung and Blood Institute (NHLBI) criteria; and the other focuses on abdominal obesity such as the International Diabetes Federation (IDF) and Japanese criteria. The latter consider waist circumference as an obligatory component, whereas the former does not. In 2009, the IDF, NHLBI, AHA and the other organizations attempted to unify these criteria, and waist circumference is no longer an obligatory component...
January 6, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28089498/anticoagulants-in-ischemia-guided-management-of-non-st-elevation-acute-coronary-syndromes
#6
REVIEW
Martin Mayer
BACKGROUND: The most recent joint guidelines from the American Heart Association (AHA) and American College of Cardiology (ACC) on the management of non-ST-elevation acute coronary syndromes (NSTE-ACS) are a result of a substantial and considered undertaking, and those involved deserve much recognition for their efforts. However, the handling of anticoagulants seems somewhat inadequate, and this is a highly-relevant matter when managing NSTE-ACS. OBJECTIVE OF THE REVIEW: Among areas of potential uncertainty, emergency medicine professionals might still be left wondering about the particulars of anticoagulant therapy when pursuing ischemia-guided management of NSTE-ACS (that is, managing NSTE-ACS without an intent for early invasive measures, such as coronary angiography and revascularization)...
January 3, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28088468/hypothalamic-effects-of-thyroid-hormone
#7
Zhi Zhang, Anita Boelen, Peter H Bisschop, Andries Kalsbeek, Eric Fliers
Thyroid hormone (TH) is a key driver of metabolism in mammals. Plasma concentrations of TH are kept within a narrow range by negative feedback regulation in the hypothalamus-pituitary-thyroid (HPT) axis. Plasma TH concentrations are an important determinant of metabolic processes in liver and brown adipose tissue (BAT). In addition to endocrine effects of TH derived from the circulation, recent studies have demonstrated additional neural routes for intrahypothalamic thyroid hormone to regulate metabolism in liver and BAT via the sympathetic and parasympathetic branch of the autonomic nervous system (ANS)...
January 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28079880/nonradioactive-quantification-of-autophagic-protein-degradation-with-l-azidohomoalanine-labeling
#8
Jigang Wang, Jianbin Zhang, Yew Mun Lee, Shukie Ng, Yin Shi, Zi-Chun Hua, Qingsong Lin, Han-Ming Shen
At present, several assays that use radioisotope labeling to quantify the degradation of long-lived proteins have been developed to measure autophagic flux. Here, we describe a nonradioactive pulse-chase protocol using L-azidohomoalanine (AHA) labeling to quantify long-lived protein degradation during autophagy. AHA is used as a surrogate for L-methionine, and, when added to cultured cells grown in methionine-free medium, AHA is incorporated into proteins during de novo protein synthesis. After a chase period to remove short-lived proteins, autophagy is induced by starvation or other stimuli...
December 2017: Nature Protocols
https://www.readbyqxmd.com/read/28079110/left-ventricular-noncompaction-cardiomyopathy-cardiac-neuromuscular-and-genetic-factors
#9
REVIEW
Josef Finsterer, Claudia Stöllberger, Jeffrey A Towbin
Left ventricular hypertrabeculation (LVHT) or noncompaction is a myocardial abnormality of unknown aetiology, frequently associated with monogenic disorders, particularly neuromuscular disorders, or with chromosomal defects. LVHT is diagnosed usually by echocardiography by the presence of a bilayered myocardium consisting of a thick, spongy, noncompacted endocardial layer and a thin, compacted, epicardial layer. The pathogenesis of LVHT is unsolved, and the diagnostic criteria, prognosis, and optimal treatment of patients with LVHT are under debate...
January 12, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28076703/a-systematic-review-to-assess-the-adherence-and-persistence-with-statins
#10
Sohan Deshpande, Ruben G W Quek, Carol A Forbes, Shelley de Kock, Jos Kleijnen, Shravanthi R Gandra, Ross J Simpson
OBJECTIVE: To identify and assess studies published over a 10-year period up to February 2016 which measure adherence or persistence with statins, to summarise their methods, strengths and weaknesses and to summarise evidence linking statin adherence/persistence with risk of cardiovascular events. METHODS: Electronic databases and abstracts from four major cardiovascular disease conferences were searched from January 2005 to February 2016. The study selection process was performed by two reviewers working independently...
January 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28074747/liraglutide-a-glucagon-like-peptide-1-agonist-for-chronic-weight-management
#11
Kendra R Manigault, Maria Miller Thurston
OBJECTIVE: To review the efficacy and safety of liraglutide 3.0 mg for weight loss. DATA SOURCE: A literature search was performed using PubMed and MEDLINE from 2000 to 2016. The following key terms were used alone or in combination: glucagon-like peptide-1 agonist, liraglutide, obesity, overweight, and weight loss. Additional supporting literature was identified utilizing the reference lists of the preceding articles. STUDY SELECTION: Analyzed studies were published in English and investigated use of liraglutide and its impact on weight loss...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28071962/the-feasibility-of-functional-electrical-stimulation-to-improve-upper-extremity-function-in-a-two-year-old-child-with-perinatal-stroke-a-case-report
#12
Kristin E Musselman, Patricia Manns, Jaclyn Dawe, Rhina Delgado, Jaynie F Yang
AIMS: To evaluate the effectiveness and feasibility (i.e. tolerability, adherence) of functional electrical stimulation (FES) for the upper extremity (UE) in a two-year-old child with perinatal stroke. METHODS: Forty hours of FES over eight weeks was prescribed. FES to the hemiplegic triceps, extensor carpi radialis longus and brevis, extensor carpi ulnaris and extensor digitorum was timed with reaching during play. Assessments were performed before, during, and two months post-intervention...
January 10, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/28063097/ideal-cardiovascular-health-and-liver-enzyme-levels-in-european-adolescents-the-helena-study
#13
Idoia Labayen, Jonatan R Ruiz, Inge Huybrechts, Francisco B Ortega, Manuel Castillo, Michael Sjöstrom, Marcela González-Gross, Yannis Manios, Kurt Widhalm, Anthony Kafatos, Christina Breidenassel, Gerardo Rodríguez, Jean Dallongeville, Frédéric Gottrand, Luis A Moreno
There is an increasing interest for the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The American Heart Association (AHA) described the ideal cardiovascular health concept as a score of seven cardiovascular health behaviors and factors that can be used to monitor and predict ideal cardiovascular health over time. This study aimed to examine the association of the ideal cardiovascular health (ICH), as defined by the AHA, with liver enzyme levels in European adolescents. A total of 637 adolescents (54...
January 6, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28059603/retention-of-basic-life-support-in-laypeople-mastery-learning-vs-time-based-education
#14
Sylvain Boet, M Dylan Bould, Ashlee-Ann Pigford, Bernhard Rössler, Pratheeban Nambyiah, Qi Li, Alexandra Bunting, Karl Schebesta
OBJECTIVE: To compare the effectiveness of a mastery learning (ML) versus a time-based (TB) BLS course for the acquisition and retention of BLS knowledge and skills in laypeople. METHODS: After ethics approval, laypeople were randomized to a ML or TB BLS course based on the American Heart Association (AHA) Heartsaver course. In the ML group, subjects practiced and received feedback at six BLS stations until they reached a pre-determined level of performance. The TB group received a standard AHA six-station BLS course...
January 6, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28058532/comparison-of-definitions-for-the-metabolic-syndrome-in-adolescents-the-helena-study
#15
Tine Vanlancker, Emmily Schaubroeck, Krishna Vyncke, Cristina Cadenas-Sanchez, Christina Breidenassel, Marcela González-Gross, Frederic Gottrand, Luis A Moreno, Laurent Beghin, Denes Molnár, Yannis Manios, Marc J Gunter, Kurt Widhalm, Catherine Leclercq, Jean Dallongeville, Marcos Ascensión, Anthony Kafatos, Manuel J Castillo, Stefaan De Henauw, Francisco B Ortega, Inge Huybrechts
: Various definitions are used to define metabolic syndrome in adolescents. This study aimed to compare, in terms of prevalence and differences, five frequently used definitions for this population: International Diabetes Federation, National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP) modified by Cook, pediatric American Heart Association (AHA), World Health Organization, and Jolliffe and Janssen. A sample of 1004 adolescents (12.5-17.0 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study was considered...
February 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28058241/convergent-validity-of-the-acc-aha-pooled-cohort-equations-in-associating-with-health-related-quality-of-life-among-adults-in-the-united-states
#16
Allison Nooe, Meghan K Edwards, Ovuokerie Addoh, Paul D Loprinzi
Background: The potential convergent validity of the pooled cohort risk (PCR) equations in predicting health-related quality of life (HRQOL) has yet to be evaluated, which was this study's purpose. Methods: Data from the 2001-2011 National Health and Nutrition Examination Survey (NHANES) were used (N = 8978 adults, 40-79 years, free of cardiovascular disease at baseline). Calculation of an individual's 10-year risk of a first atherosclerotic cardiovascular disease (ASCVD) event was determined via the PCR equation...
2017: Health Promotion Perspectives
https://www.readbyqxmd.com/read/28045408/-2016-esc-and-acc-aha-hfsa-heart-failure-guideline-updates-changes-similarities-differences-and-unresolved-isssues
#17
EDITORIAL
İbrahim Sarı, Yüksel Çavuşoğlu, Ahmet Temizhan, Mehmet Birhan Yılmaz, Mehmet Eren
No abstract text is available yet for this article.
December 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28039493/new-markers-in-atherosclerosis-thrombospondin-2-thbs-2-and-leukocyte-cell-derived-chemotaxin-2-lect-2-an-immunohistochemical-study
#18
Fatma Cavide Sonmez, Pelin Yildiz, Muhammad Salman Akhtar, Cemalettin Aydin, Osman Sonmez, Nuray Ay, Mehmet Akif Vatankulu
BACKGROUND Current research investigating the role of THBS2 and LECT-2 in atherogenesis is very limited. Therefore, we designed this study to demonstrate the role of THBS-2 and LECT-2 in atherosclerosis at the tissue level in fresh specimens. MATERIAL AND METHODS A total of 32 patients who underwent coronary bypass surgery were enrolled. Aortic wall punch biopsies were obtained at the site of proximal aortosaphenous bypass graft anastomosis. A specimen of left internal mammarian artery (LiMA) was taken from the segment just proximal to its anastomosis...
December 31, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28038806/bioresorbable-coronary-stent-for-the-treatment-of-complex-coronary-lesions-data-from-an-all-comer-registry
#19
Andrea Cuculo, Antonio Ruggiero, Antonio Centola, Giulio Campanale, Tommaso Passero, Antonio Gaglione, Matteo Di Biase, Natale Daniele Brunetti
BACKGROUND: The study aimed to report the results from an all-comers registry of patients undergoing coronary angioplasty and treated with bioresorbable vascular scaffold (BVS). METHODS: Fifty-five consecutive patients with type B/C coronary lesions according to the AHA classification and treated with BVS were enrolled in the study. The clinical and procedural characteristics of enrolled patients were recorded. Fifty-five consecutive subjects with coronary lesions type B/C treated with everolimus eluting stent (EES) were used as control group...
December 19, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28029013/application-of-the-2013-american-college-of-cardiology-american-heart-association-cholesterol-guideline-to-the-korean-national-health-and-nutrition-examination-surveys-from-1998-to-2012
#20
Young Shin Song, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang, Kyong Soo Park, Soo Lim
BACKGROUND: The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline for the treatment of blood cholesterol recommends statin therapy for individuals at high risk of atherosclerotic cardiovascular disease (ASCVD). The aim of this study was to investigate serial trends in the percentages of Korean adults considered eligible for statin therapy according to the new ACC/AHA cholesterol guideline. METHODS: Data from the Korean National Health and Nutrition Examination Survey (KNHANES) I (1998, n=7,698), II (2001, n=5,654), III (2005, n=5,269), IV (2007 to 2009, n=15,727), and V (2010 to 2012, n=16,304), which used a stratified, multistage, probability sampling design, were used as representative of the entire Korean population...
December 16, 2016: Diabetes & Metabolism Journal
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