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https://www.readbyqxmd.com/read/29456547/evolutionary-origin-gradual-accumulation-and-functional-divergence-of-heat-shock-factor-gene-family-with-plant-evolution
#1
Xiaoming Wang, Xue Shi, Siyuan Chen, Chuang Ma, Shengbao Xu
Plants, as sessile organisms, evolved a complex and functionally diverse heat shock factor (HSF) gene family to cope with various environmental stresses. However, the limited evolution studies of the HSF gene family have hindered our understanding of environmental adaptations in plants. In this study, a comprehensive evolution analysis on the HSF gene family was performed in 51 representative plant species. Our results demonstrated that the HSFB group which lacks a typical AHA activation domain, was the most ancient, and is under stronger purifying selection pressure in the subsequent evolutionary processes...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29453664/analysis-of-transactivation-potential-of-rice-oryza-sativa-l-heat-shock-factors
#2
Dhruv Lavania, Anuradha Dhingra, Anil Grover
Based on yeast one-hybrid assays, we show that the presence of C-terminal AHA motifs is not a prerequisite for transactivation potential in rice heat shock factors. Transcriptional activation or transactivation (TA) of heat stress responsive genes takes place by binding of heat shock factors (Hsfs) to heat shock elements. Analysis of TA potential of thirteen rice (Oryza sativa L.) Hsfs (OsHsfs) carried out in this study by yeast one-hybrid assay showed that OsHsfsA3 possesses strong TA potential while OsHsfs A1a, A2a, A2b, A4a, A4d, A5, A7b, B1, B2a, B2b, B2c and B4d lack TA potential...
February 16, 2018: Planta
https://www.readbyqxmd.com/read/29452626/translation-of-an-evidence-based-therapeutic-exercise-program-for-patients-with-peripheral-artery-disease
#3
Dereck L Salisbury, Mary O Whipple, Marsha Burt, Rebecca J L Brown, Alan Hirsch, Christopher Foley, Diane Treat-Jacobson
The purpose of this study was to implement and evaluate quality outcomes including referral, enrollment, and completion rates of a new peripheral artery disease (PAD)-specific supervised exercise therapy (SET) program within a preexisting clinical exercise wellness program and to evaluate the clinical effectiveness and patient-centered outcomes derived from 12 weeks of PAD-specific SET. Recruited participants completed an individualized, minimally supervised, PAD-specific SET program based on the AHA-ACC guidelines...
March 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29449338/status-of-hypertension-in-china-results-from-the-china-hypertension-survey-2012-2015
#4
Zengwu Wang, Zuo Chen, Linfeng Zhang, Xin Wang, Guang Hao, Zugui Zhang, Lan Shao, Ye Tian, Ying Dong, Congyi Zheng, Jiali Wang, Manlu Zhu, William S Weintraub, Runlin Gao
Background -Although the prevalence of hypertension (HTN) continues to increase in developing countries including China, recent data are lacking. A national wide survey was conducted from October 2012 to December 2015 to assess the prevalence of HTN in China. Methods -A stratified multistage random sampling method was used to obtain a nationally representative sample of 451,755 residents aged ≥18 years from 31 provinces in mainland China from October 2012 to December 2015. Blood pressure (BP) was measured after resting for 5 minutes by trained staff, using a validated oscillometric BP monitor...
February 15, 2018: Circulation
https://www.readbyqxmd.com/read/29447789/comprehensive-electrocardiogram-to-device-time-for-primary-percutaneous-coronary-intervention-in-st-segment-elevation-myocardial-infarction-a-report-from-the-american-heart-association-mission-lifeline-program
#5
Jay S Shavadia, William French, Anne S Hellkamp, Laine Thomas, Eric R Bates, Steven V Manoukian, Michael C Kontos, Robert Suter, Timothy D Henry, Harold L Dauerman, Matthew T Roe
BACKGROUND: Assessing hospital-related network-level primary percutaneous coronary intervention (PCI) performance for ST-segment elevation myocardial infarction (STEMI) is challenging due to differential time-to-treatment metrics based on location of diagnostic electrocardiogram (ECG) for STEMI. METHODS: STEMI patients undergoing primary PCI at 588 PCI-capable hospitals in AHA Mission: Lifeline (2008-2013) were categorized by initial STEMI identification location: PCI-capable hospitals (Group 1); pre-hospital setting (Group 2); and non-PCI-capable hospitals (Group 3)...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29445308/cpr-in-medical-tv-shows-non-health-care-student-perspective
#6
Abdullah Alismail, Nicole C Meyer, Waleed Almutairi, Noha S Daher
Introduction: There are over a dozen medical shows airing on television, many of which are during prime time. Researchers have recently become more interested in the role of these shows, and the awareness on cardiopulmonary resuscitation. Several cases have been reported where a lay person resuscitated a family member using medical TV shows as a reference. The purpose of this study is to examine and evaluate college students' perception on cardiopulmonary resuscitation and when to shock using an automated external defibrillator based on their experience of watching medical TV shows...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29444987/cardiovascular-risk-prediction-functions-underestimate-risk-in-hiv-infection
#7
Virginia A Triant, Jeremiah Perez, Susan Regan, Joseph M Massaro, James B Meigs, Steven K Grinspoon, Ralph B D'Agostino
Background -Cardiovascular disease (CVD) risk is elevated in HIV-infected individuals, with contributions from both traditional and non-traditional risk factors. The accuracy of established CVD risk prediction functions in HIV is uncertain. We sought to assess the performance of three established CVD risk prediction functions in a longitudinal cohort of HIV-infected men. Methods -Framingham Heart Study (Framingham) functions for hard coronary heart disease (Framingham CHD) and atherosclerotic CVD (Framingham ASCVD) and the American College of Cardiology/American Heart Association (ACC/AHA ASCVD) function were applied to the Partners HIV cohort...
February 14, 2018: Circulation
https://www.readbyqxmd.com/read/29443524/encapsulation-of-ionic-liquids-with-an-aprotic-heterocyclic-anion-aha-il-for-co-2-capture-preserving-the-favorable-thermodynamics-and-enhancing-the-kinetics-of-absorption
#8
Cristian Moya, Noelia Alonso-Morales, Juan de Riva, Oscar Morales-Collazo, Joan Frances Brennecke, José Palomar
The performance in CO2 capture of an ionic liquid with an aprotic heterocyclic anion (AHA-IL), trihexyl(tetradecyl)phosphonium 2-cyanopyrrolide ([P66614][2-CNPyr]), has been evaluated considering both the thermodynamics and the kinetics of the phenomena. Absorption gravimetric measurements of the gas-liquid equilibrium isotherms of CO2 - AHA-IL systems were carried out from 298K to 333 K and pressures to 15 bar, analyzing the role of both chemical and physical absorption on the overall CO2 solubility in the AHA-IL, as has been done previously...
February 14, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29440909/clinical-characteristics-patterns-of-lipid-lowering-medication-use-and-health-care-resource-utilization-and-costs-among-patients-with-atherosclerotic-cardiovascular-disease
#9
Thomas P Power, Xuehua Ke, Zhenxiang Zhao, Nicole Gidaya Bonine, Mark J Cziraky, Michael Grabner, John J Barron, Ralph Quimbo, Burkhard Vangerow, Peter P Toth
Purpose: The aim of this study was to investigate real-world patient characteristics, medication use, and health care resource utilization (HCRU) and costs among patients with clinical atherosclerotic cardiovascular disease (ASCVD) as defined by 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines, to examine burden of disease and unmet needs, such as potential undertreatment. Patients and methods: This retrospective cohort study utilized a nationally representative managed care database to identify newly diagnosed ASCVD patients between January 1, 2007, and November 30, 2012 (index = first ASCVD diagnosis date) in the USA...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29440497/structural-insights-into-the-mechanism-of-inhibition-of-ahas-by-herbicides
#10
Thierry Lonhienne, Mario D Garcia, Gregory Pierens, Mehdi Mobli, Amanda Nouwens, Luke W Guddat
Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway, is present only in plants and microorganisms, and it is the target of >50 commercial herbicides. Penoxsulam (PS), which is a highly effective broad-spectrum AHAS-inhibiting herbicide, is used extensively to control weed growth in rice crops. However, the molecular basis for its inhibition of AHAS is poorly understood. This is despite the availability of structural data for all other classes of AHAS-inhibiting herbicides...
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29436247/comparing-the-value-of-nonprofit-hospitals-tax-exemption-to-their-community-benefits
#11
Bradley Herring, Darrell Gaskin, Hossein Zare, Gerard Anderson
The tax-exempt status of nonprofit hospitals has received increased attention from policymakers interested in examining the value they provide instead of paying taxes. We use 2012 data from the Internal Revenue Service (IRS) Form 990, Centers for Medicare and Medicaid Services (CMS) Hospital Cost Reports, and American Hospital Association's (AHA) Annual Survey to compare the value of community benefits with the tax exemption. We contrast nonprofit's total community benefits to what for-profits provide and distinguish between charity and other community benefits...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29430508/decreased-invasion-of-urothelial-carcinoma-of-the-bladder-by-inhibition-of-matrix-metalloproteinase-7
#12
Christian Bolenz, Daniel Knauf, Axel John, Philipp Erben, Annette Steidler, Stefan W Schneider, Cagatay Günes, Christian Gorzelanny
Objectives: To measure and to modulate the invasive potential of urothelial carcinoma of the bladder (UCB) cells in a standardized preclinical setting using broad-spectrum matrix-metalloproteinase (MMPs) inhibitors and specific targeting of MMP7. Materials and Methods: MMP expression levels in UCB cells were determined by quantitative real-time PCR (qRT-PCR) and gel zymographies of cell supernatants (MMP9, MMP2 and MMP1) and cell lysates (MMP7). The invasiveness of human UCB cells (HT1197 and T24/83) and human benign urothelial cells (UROtsa) was modulated by a broad-spectrum MMP inhibitor (4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid; AHA) and by MMP7 specific siRNAs...
January 20, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29426145/sunlight-irradiation-triggers-changes-in-the-fouling-potentials-of-natural-dissolved-organic-matter
#13
Zhongbo Zhou, Minghao Zhou, Xiaofang Yang, Junfeng Niu, Fangang Meng
Sunlight-initiated photodegradation has a great impact on the composition and properties of natural dissolved organic matter (DOM) in aquatic environments, which potentially changes the behavior and roles of DOM in water treatment facilities. Here, we explored the effect of sunlight irradiation on membrane fouling behavior of two natural DOM (i.e., Aldrich humic acid (AHA) and Suwannee River DOM (SRNOM)), particularly in the presence of calcium ion (Ca(II)). Results showed that a long-term exposure (3 months) to sunlight during the summer led to decreases in the chromophores and molecular size of both DOM...
January 29, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29425623/why-hospitals-adopt-patient-engagement-functionalities-at-different-speeds-a-moderated-trend-analysis
#14
O Elijah Asagbra, Darrell Burke, Huigang Liang
OBJECTIVE: To investigate acute care hospitals' adoption speed of patient engagement health information technology (HIT) functionalities from 2008 to 2013 and how this speed is contingent on environmental factors and hospital characteristics. METHODS: Data on non-government acute care hospitals located in the United States was obtained from merging three databases: the American Hospital Association's (AHA) annual survey information technology supplement, AHA annual survey, and the Area Health Resource File (AHRF)...
March 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29424952/effects-of-resistance-mutations-of-pro197-asp376-and-trp574-on-the-characterization-of-acetohydroxyacid-synthase-ahas-isozymes
#15
Qian Yang, Wei Deng, Shipeng Wang, Hongjie Liu, Xuefeng Li, Mingqi Zheng
BACKGROUND: Descurainia sophia L., a problematic weed in winter wheat fields in China, has developed high resistance to tribenuron-methyl. Amino acid substitutions at sites Pro197, Asp376 and Trp574 in the target acetohydroxyacid synthase (AHAS) were primarily responsible for D. sophia resistance to tribenuron-methyl. In this study, D. sophia plants individually homozygous for a specific resistance mutation (Pro197Leu, Pro197His, Pro197Ser, Pro197Thr, Asp376Glu or Trp574Leu) in AHAS were purified and generated, and the effects of resistance mutations on D...
February 9, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29423902/a-novel-substrate-radiotracer-for-molecular-imaging-of-sirt2-expression-and-activity-with-positron-emission-tomography
#16
Robin E Bonomi, Maxwell Laws, Vadim Popov, Swatabdi Kamal, Shreya Potukutchi, Aleksandr Shavrin, Xin Lu, Nashaat Turkman, Ren-Shyan Liu, Thomas Mangner, Juri G Gelovani
PURPOSE: The purpose of this study was to develop a SIRT2-specific substrate-type radiotracer for non-invasive PET imaging of epigenetic regulatory processes mediated by SIRT2 in normal and disease tissues. PROCEDURES: A library of compounds containing tert-butyloxycarbonyl-lysine-aminomethylcoumarin backbone was derivatized with fluoroalkyl chains 3-16 carbons in length. SIRT2 most efficiently cleaved the myristoyl, followed by 12-fluorododecanoic and 10-fluorodecanoic groups (Kcat/Km 716...
February 8, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29422726/audit-of-postoperative-surgical-intensive-care-unit-admissions
#17
Shaili K Patel, Samir M Kacheriwala, Dipesh D Duttaroy
Objective: The objective of this study was to conduct an audit of Surgical Intensive Care Unit (SICU) for identifying the admission risk factors and evaluating the outcomes of postoperative surgical patients. Design: This was a prospective, observational study. Setting: This study was conducted at SICU of a 1500-bedded tertiary care university hospital in Western India. Subject and Methods: Two hundred and forty patients admitted to the SICU postoperatively over a period of 15 months...
January 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29421687/baseline-blood-pressure-the-2017-acc-aha-high-blood-pressure-guidelines-and-long-term-cardiovascular-risk-in-sprint
#18
Muthiah Vaduganathan, Manan Pareek, Arman Qamar, Ambarish Pandey, Michael H Olsen, Deepak L Bhatt
BACKGROUND: The 2017 ACC/AHA guidelines include lower thresholds to define hypertension than previous guidelines. Little is known about the impact of these guideline changes in patients with or at high risk for cardiovascular disease. METHODS: In this exploratory analysis using baseline blood pressure assessments in SPRINT (Systolic Blood Pressure Intervention Trial), we evaluated the prevalence and associated cardiovascular prognosis of patients newly reclassified with hypertension based on the 2017 ACC/AHA (SBP≥130mmHg or DBP≥80mmHg) compared with the JNC 7 guidelines (SBP≥140mmHg or DBP≥90mmHg)...
February 5, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29420547/coronary-artery-calcium-before-and-after-hospitalization-with-pneumonia-the-mesa-study
#19
Vicente F Corrales-Medina, Girish Dwivedi, Monica Taljaard, William Petrcich, Joao A Lima, Sachin Yende, Richard A Kronmal, Julio A Chirinos
BACKGROUND: Epidemiological analyses demonstrate that pneumonia survivors have a higher risk of myocardial infarction than people with similar load of risk factors for atherosclerotic cardiovascular disease (ASCVD) but without pneumonia. This may be due to a higher baseline burden of ASCVD in patients with pneumonia that is not captured by the accounting of known ASCVD risk factors in epidemiological analyses or to unfavorable accelerating effects of pneumonia on atherosclerosis. METHODS: We analyzed data from the Multi-Ethnic Study of Atherosclerosis...
2018: PloS One
https://www.readbyqxmd.com/read/29419821/the-use-of-individual-provider-performance-reports-by-us-hospitals
#20
Joshua A Rolnick, Kira L Ryskina
Medicare reimbursement for hospitals is increasingly tied to performance. The use of individual provider performance reports offers the potential to improve clinical outcomes through social comparison, and isolated cases of clinical dashboard uses at specific institutions have been previously reported. However, little is known about overall trends in how hospitals use the electronic health record to track and provide feedback on provider performance. We used data from 2013 to 2015 from the American Hospital Association (AHA) Annual Survey Information Technology Supplement, which asked hospitals if they have used electronic data to create performance profiles...
February 7, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
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