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https://www.readbyqxmd.com/read/29243152/transgene-escape-and-persistence-in-an-agroecosystem-the-case-of-glyphosate-resistant-brassica-rapa-l-in-central-argentina
#1
Claudio E Pandolfo, Alejandro Presotto, Francisco Torres Carbonell, Soledad Ureta, Mónica Poverene, Miguel Cantamutto
Brassica rapa L. is an annual Brassicaceae species cultivated for oil and food production, whose wild form is a weed of crops worldwide. In temperate regions of South America and especially in the Argentine Pampas region, this species is widely distributed. During 2014, wild B. rapa populations that escaped control with glyphosate applications by farmers were found in this area. These plants were characterized by morphology and seed acidic profile, and all the characters agreed with B. rapa description. The dose-response assays showed that the biotypes were highly resistant to glyphosate...
December 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29242891/diagnosis-and-treatment-of-hypertension-in-the-2017-acc-aha-guidelines-and-in-the-real-world
#2
John P A Ioannidis
No abstract text is available yet for this article.
December 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29241844/efficacy-and-safety-of-routine-aspiration-thrombectomy-during-primary-pci-for-st-segment-elevation-myocardial-infarction-a-metanalysis-of-large-randomized-controlled-trials
#3
Konstantinos Marmagkiolis, Abdul Hakeem, Mehmet Cilingiroglu, Dmitriy N Feldman, Konstantinos Charitakis
BACKGROUND: Recent randomized controlled trials (RCTs) have questioned the clinical efficacy and even safety of routine aspiration thrombectomy (AT) during primary PCI. A systematic synthesis of these randomized data is hence very timely to address this clinical equipoise. METHODS: We performed a meta-analysis of the larger (>150 patients) Randomized Controlled Trials (RCT) which compared aspiration thrombectomy with primary PCI alone. Procedural end-points were Myocardial Blush Grade (MBG) of 0 or 1 and ST segment resolution (STR) of >50%...
December 11, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29237294/mutagenicity-evaluation-of-anastatica-hierochuntica-l-aqueous-extract-in-vitro-and-in-vivo
#4
Siti Rosmani Md Zin, Zahurin Mohamed, Mohammed A Alshawsh, Won F Wong, Normadiah M Kassim
Anastatica hierochuntica L. ( A. hierochuntica), a folk medicinal plant, was evaluated for mutagenic potential via in vitro and in vivo assays. The in vitro assay was conducted according to modified Ames test, while the in vivo study was performed according to Organisation for Economic Co-operation and Development guideline for mammalian erythrocyte micronucleus assay. Four groups ( n= 5 males and 5 females per group) Sprague Dawley rats were randomly chosen as the negative control, positive control (received a single intramuscular injection of cyclophosphamide 50 mg/kg), 1000 and, 2000 mg/kg A...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29230658/guidelines-in-review-comparison-of-the-2014-aha-acc-guideline-for-the-management-of-patients-with-non-st-elevation-acute-coronary-syndromes-and-the-2015-esc-guidelines-for-the-management-of-acute-coronary-syndromes-in-patients-presenting-without-persistent
#5
Shane P Prejean, Munaib Din, Eliana Reyes, Fadi G Hage
In this Guidelines in Review, we review side-by-side the recommendations provided by the 2014 AHA/ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes and the 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. We review the recommendations for imaging in the evaluation of patients with possible ACS followed by the diagnostic evaluation of patients with proven NSTE-ACS, based on their risk for adverse clinical events...
December 11, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29229400/tumor-necrosis-factor-producing-t-regulatory-cells-are-associated-with-severe-liver-injury-in-patients-with-acute-hepatitis-a
#6
Yoon Seok Choi, Min Kyung Jung, Jeewon Lee, Seong Jin Choi, Sung Hoon Choi, Hyun Woong Lee, Jong-Joo Lee, Hyung Joon Kim, Sang Hoon Ahn, Dong Hyeon Lee, Won Kim, Su-Hyung Park, Jun R Huh, Hyoung-Pyo Kim, Jun Yong Park, Eui-Cheol Shin
BACKGROUND AND AIMS: CD4+CD25+Foxp3+ T-regulatory (Treg) cells control immune responses and maintain immune homeostasis. However, under inflammatory conditions, Treg cells produce cytokines that promote inflammation. We investigated production of tumor necrosis factor (TNF) by Treg cells in patients with acute hepatitis A (AHA), and examined the characteristics of these cells and association with clinical factors. METHODS: We analyzed blood samples collected from 63 patients with AHA at the time of hospitalization (and some at later time points) and 19 healthy donors in South Korea...
December 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29228096/the-new-acc-aha-hypertension-guidelines-for-the-prevention-detection-evaluation-and-management-of-high-blood-pressure-in-adults
#7
John M Flack, David Calhoun, Ernesto L Schiffrin
No abstract text is available yet for this article.
December 7, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29223083/activity-toxicity-molecular-docking-and-environmental-effects-of-three-imidazolinone-herbicides-enantiomers
#8
Jingqian Xie, Lu Zhao, Kai Liu, Fangjie Guo, Lidi Gao, Weiping Liu
All imidazolinone (IMI) herbicides are chiral consisting of two enantiomers; however, studies on the enantioselectivities of their interactions are limited. This study is a systematic assessment of the enantiomers and racemates of IMI herbicides, including semi-preparation and determination of absolute configurations, stereoselective bioactivity toward target organisms (Echinochloa crus-galli and Microcystis aeruginosa), and toxicity toward Michigan Cancer Foundation-7 (MCF-7) cells. R-imidazolinones were found to be more active than S-IMIs in the inhibition of target organisms, and neither enantiomer had estrogenic activity...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29221300/comparison-of-continuous-compression-with-regular-ventilations-versus-30-2-compressions-ventilations-strategy-during-mechanical-cardiopulmonary-resuscitation-in-a-porcine-model-of-cardiac-arrest
#9
Zhengfei Yang, Qingyu Liu, Guanghui Zheng, Zhifeng Liu, Longyuan Jiang, Qing Lin, Rui Chen, Wanchun Tang
Background: A compression-ventilation (C:V) ratio of 30:2 is recommended for adult cardiopulmonary resuscitation (CPR) by the current American Heart Association (AHA) guidelines. However, continuous chest compression (CCC) is an alternative strategy for CPR that minimizes interruption especially when an advanced airway exists. In this study, we investigated the effects of 30:2 mechanical CPR when compared with CCC in combination with regular ventilation in a porcine model. Methods: Sixteen male domestic pigs weighing 39±2 kg were utilized...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29217717/2017-aha-late-breaking-basic-science-abstracts
#10
(no author information available yet)
No abstract text is available yet for this article.
December 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/29216947/-effects-of-active-abdominal-compression-decompression-cpr-on-oxygen-metabolism-and-prognosis-in-patients-with-cardiac-arrest
#11
Xin Sha, Sisen Zhang, Hongwei Wang, Yingxin Cen, Wei Song, Jing Li, Lixiang Wang
OBJECTIVE: To analyze the effect of active abdominal compression-decompression cardiopulmonary resuscitation (AACD-CPR) and standard cardiopulmonary resuscitation (STD-CPR) on oxygen metabolism and prognosis of patient with cardiac arrest (CA), and to evaluate the treatment effect of AACD-CPR. METHODS: Patients with CA, CA time less than 30 minutes, and without STD-CPR and AACD-CPR contraindications admitted to the Zhengzhou People's Hospital from October 1st 2015 to May 31st 2017 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216431/photochemistry-of-acetohydroxamic-acid-in-solid-argon-ftir-and-theoretical-studies
#12
Magdalena Sałdyka, Zofia Mielke
The products formed during exposure of the CH3CONHOH/Ar (AHA/Ar) matrices to the full output of the Xe lamp and to 225 nm OPO radiation are studied. The irradiation promotes the isomerization, 1Z -1E, and AHA photodissociation reactions. Four pairs of co-products are experimentally found to appear in the photolysis, they form the complexes: CH3OH-HNCO (1), H2O-CH3NCO (2), H2O-CH3CNO (3) and CO-CH3NHOH (4). The structures of the complexes were optimized at the MP2 computational level with the 6-311++G(2d,2p) and aug-cc-pVTZ basis sets...
December 7, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29212866/acquired-haemophilia-a-complicating-alemtuzumab-therapy-for-multiple-sclerosis
#13
Georgia McCaughan, Jennifer Massey, Ian Sutton, Jennifer Curnow
Alemtuzumab is a highly efficacious therapy used in the treatment of multiple sclerosis (MS), but uncoupling of T and B cell repopulation during immune reconstitution associates with an increasing range of secondary B cell-mediated autoimmune complications. A 34-year-old woman developed Graves' disease 11 months following an initial course of alemtuzumab treatment for MS. Nine months following the second treatment with alemtuzumab, the patient presented with spontaneous intramuscular and subcutaneous haemorrhage due to development of an inhibitory autoantibody to coagulation factor VIII...
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29210976/therapeutic-drug-monitoring-of-asparaginase-activity-method-comparison-of-maattm-and-aha-test-used-in-the-international-aieop-bfm-all-2009-trial
#14
Claudia Lanvers-Kaminsky, Andrea Rüffer, Gudrun Würthwein, Joachim Gerss, Massimo Zucchetti, Andrea Ballerini, Andishe Attarbaschi, Petr Smisek, Christa Nath, Samiuela Lee, Sara Elitzur, Martin Zimmermann, Anja Möricke, Martin Schrappe, Carmelo Rizzari, Joachim Boos
BACKGROUND: In the international AIEOP-BFM ALL 2009 trial, asparaginase (ASE) activity was monitored after each dose of pegylated E. coli ASE (PEG-ASE). Two methods were used: the AHA test and MAAT. As the latter method overestimates PEG-ASE activity because it calibrates using E. coli ASE, method comparison was performed using samples from the AIEOP-BFM ALL 2009 trial. METHODS: PEG-ASE activities were determined by MAAT and AHA test in two sets of samples (1st set: 630 samples; 2nd set: 91 samples)...
November 23, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29205910/role-of-intravenous-immunoglobulin-in-the-treatment-of-kawasaki-disease
#15
Mindy S Lo, Jane W Newburger
Intravenous immunoglobulin (IVIg) is a purified plasma product that is used for many immune-deficient conditions and autoimmune conditions. Use of IVIg for treatment for Kawasaki disease (KD) is critical for control of inflammation. The American Heart Association (AHA) recommends a single infusion of 2 g/kg preferably given during the first 10 days of illness. In this review, we have discussed the possible mechanisms of action of IVIg in KD and its clinical usage in this condition.
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29204627/the-acc-aha-2017-hypertension-guidelines-both-too-much-and-not-enough-of-a-good-thing
#16
Jordana B Cohen, Raymond R Townsend
No abstract text is available yet for this article.
December 5, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29203036/comparison-of-the-prognostic-usefulness-of-the-european-society-of-cardiology-and-american-heart-association-american-college-of-cardiology-foundation-risk-stratification-systems-for-patients-with-hypertrophic-cardiomyopathy
#17
Kevin M W Leong, Ji-Jian Chow, Fu Siong Ng, Emanuela Falaschetti, Norman Qureshi, Michael Koa-Wing, Nicholas W F Linton, Zachary I Whinnett, David C Lefroy, D Wyn Davies, Phang Boon Lim, Nicholas S Peters, Prapa Kanagaratnam, Amanda M Varnava
Implantable cardiodefibrillators (ICDs) have proven benefit in preventing sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HC), making risk stratification essential. Data on the predictive accuracy on the European Society of Cardiology (ESC) risk scoring system have been conflicting. We independently evaluated the ESC risk scoring system in our cohort of patients with HC from a large tertiary center and compared this with previous guidance by the American College of Cardiology Foundation and Heart Association (ACCF/AHA)...
November 7, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29196789/prediction-of-functional-recovery-after-primary-pci-using-the-estimate-of-myocardial-salvage-in-gated-spect-early-after-acute-myocardial-infarction
#18
Raffaella Calabretta, Angelo Castello, Flavia Linguanti, Francesca Tutino, Alfonso Ciaccio, Cristina Giglioli, Roberto Sciagrà
PURPOSE: Primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) aims to achieve myocardial salvage (MS). Because the reference method for measuring MS requires myocardial perfusion imaging (MPI) after tracer injection before PCI, alternative approaches have been proposed, but none has gained wide acceptance. Gated SPECT MPI can assess infarct size (IS), but can also show myocardial stunning. Thus, we compared functional and perfusion abnormalities early after AMI to estimate MS, and to predict left ventricular ejection fraction (LVEF) recovery at follow-up...
December 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29191832/molecular-characterization-of-human-anti-hinge-antibodies-derived-from-single-cell-cloning-of-normal-human-b-cells
#19
Tao Huang, Mary Mathieu, Sophia Lee, Xinhua Wang, Yee Seir Kee, Jack J Bevers, Claudio Ciferri, Alberto Estavez, Manda Wong, Nancy Y Chiang, Gerald Nakamura, Randall J Brezski
Anti-hinge antibodies (AHAs) are an autoantibody subclass that, following proteolytic cleavage, recognize cryptic epitopes exposed in the hinge regions of immunoglobulins (Igs) and do not bind to the intact Ig counterpart. AHAs have been postulated to exacerbate chronic inflammatory disorders such as inflammatory bowel disease and rheumatoid arthritis. On the other hand, AHAs may protect against invasive microbial pathogens and cancer. However, despite more than 50 years of study, the origin and specific B cell compartments that express AHAs remain elusive...
November 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29188761/metabolic-syndrome-and-cardiovascular-risk-assessment-tools-estimations-of-10-year-cardiovascular-risk-a-population-based-study
#20
Nima Motamed, Behnam Rabiee, Farzin Roozafzai, Farhad Zamani, Amir Hossein Faraji, Mansooreh Maadi, Hossein Keyvani, Mahmood Reza Khonsari, Gholam Reza Hemasi
BACKGROUND: This cross-sectional study determines the association between 10-year cardiovascular disease (CVD) risk, estimated using four CVD risk assessment tools, and metabolic syndrome (MetS) in northern Iranian general population. METHODS: We used the data of 2371 participants aged 40-74 without any history of diabetes mellitus from a cohort study conducted among 6140 subjects aged 10-90 years in northern Iran. Three definitions of MetS were used. The four CVD risk assessment tools used to estimate the 10-year CVD risk included pooled cohort equations of ACC/AHA, Systematic Coronary Risk Evaluation (SCORE) equations (for low-risk and high-risk European countries), and Framingham general cardiovascular risk profile for use in primary care...
November 30, 2017: Acta Cardiologica
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