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https://www.readbyqxmd.com/read/28928197/impact-of-oral-self-care-on-incident-functional-disability-in-elderly-japanese-the-ohsaki-cohort-2006-study
#1
Shino Bando, Yasutake Tomata, Jun Aida, Kemmyo Sugiyama, Yumi Sugawara, Ichiro Tsuji
OBJECTIVES: To assess whether oral self-care (tooth brushing, regular dental visits and use of dentures) affects incident functional disability in elderly individuals with tooth loss. DESIGN: A 5.7-year prospective cohort study. SETTING: Ohsaki City, Japan. PARTICIPANTS: 12 370 community-dwelling individuals aged 65 years and older. PRIMARY OUTCOME MEASURES: Incident functional disability (new long-term care insurance certification)...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28923400/mitf-suppression-improves-the-sensitivity-of-melanoma-cells-to-a-braf-inhibitor
#2
Satoshi Aida, Yukiko Sonobe, Hiromi Tanimura, Nobuhiro Oikawa, Munehiro Yuhki, Hiroshi Sakamoto, Takakazu Mizuno
Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Here, we report the identification of CH6868398, which has a novel chemical structure and suppresses MITF expression at the protein level in melanoma cells. CH6868398 showed cell growth inhibition activity against MITF-dependent melanoma cells both with and without BRAF mutation and also exhibited anti-tumor efficacy in a melanoma xenograft model...
September 15, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28919082/diabetes-mellitus-and-obesity-as-risk-factors-for-pancreatic-cancer
#3
Guido Eibl, Zobeida Cruz-Monserrate, Murray Korc, Maxim S Petrov, Mark O Goodarzi, William E Fisher, Aida Habtezion, Aurelia Lugea, Stephen J Pandol, Phil A Hart, Dana K Andersen
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030...
September 11, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28918190/autophagy-inflammation-and-immune-dysfunction-in-the-pathogenesis-of-pancreatitis
#4
REVIEW
Anna S Gukovskaya, Ilya Gukovsky, Hana Algül, Aida Habtezion
Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease severity depends on whether the inflammatory response resolves or amplifies, leading to multi-organ failure. Dysregulated autophagy might promote the inflammatory response in the pancreas. We discuss the roles of autophagy and inflammation in pancreatitis, mechanisms of deregulation, and connections among disordered pathways...
September 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28915977/corrigendum-to-reduced-nitric-oxide-mediated-relaxation-and-endothelial-nitric-oxide-synthase-expression-in-the-tail-arteries-of-streptozotocin-induced-diabetic-rats-eur-j-pharmacol-773-2016-78-84
#5
Siti Safiah Mokhtar, Paul M Vanhoutte, Susan Wai Sum Leung, Rapeah Suppian, Mohd Imran Yusof, Aida Hanum Ghulam Rasool
No abstract text is available yet for this article.
October 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28914998/clinicopathological-characteristics-of-distant-metastases-of-adenocarcinoma-squamous-cell-carcinoma-and-urothelial-carcinoma-an-autopsy-study-of-older-japanese-patients
#6
Yoko Matsuda, Atsuko Seki, Keisuke Nonaka, Mototsune Kakizaki, Tan Wang, Junko Aida, Naoshi Ishikawa, Yuta Nakano, Daita Kaneda, Tadayuki Takata, Junko Takahashi-Fujigasaki, Shigeo Murayama, Kaiyo Takubo, Toshiyuki Ishiwata, Motoji Sawabe, Tomio Arai
AIM: We aimed to clarify the characteristics of malignancies in older adults focusing on distant metastasis in the whole body. METHODS: We retrospectively evaluated 7710 cases of autopsies (4011 men, 3699 women, median age of 80 years), and analyzed the characteristics of metastasis of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma in each organ. RESULTS: The total number of cases with adenocarcinoma, squamous cell carcinoma or urothelial carcinoma was 2856, and most of them were adenocarcinomas...
September 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28913418/unveiling-the-role-and-life-strategies-of-viruses-from-the-surface-to-the-dark-ocean
#7
Elena Lara, Dolors Vaqué, Elisabet Laia Sà, Julia A Boras, Ana Gomes, Encarna Borrull, Cristina Díez-Vives, Eva Teira, Massimo C Pernice, Francisca C Garcia, Irene Forn, Yaiza M Castillo, Aida Peiró, Guillem Salazar, Xosé Anxelu G Morán, Ramon Massana, Teresa S Catalá, Gian Marco Luna, Susana Agustí, Marta Estrada, Josep M Gasol, Carlos M Duarte
Viruses are a key component of marine ecosystems, but the assessment of their global role in regulating microbial communities and the flux of carbon is precluded by a paucity of data, particularly in the deep ocean. We assessed patterns in viral abundance and production and the role of viral lysis as a driver of prokaryote mortality, from surface to bathypelagic layers, across the tropical and subtropical oceans. Viral abundance showed significant differences between oceans in the epipelagic and mesopelagic, but not in the bathypelagic, and decreased with depth, with an average power-law scaling exponent of -1...
September 2017: Science Advances
https://www.readbyqxmd.com/read/28905525/new-insights-on-the-mechanism-of-action-of-pyrazolo-1-2-a-benzo-1-2-3-4-tetrazin-3-one-derivatives-pbts-endowed-with-anticancer-potential
#8
Antonino Lauria, Francesco Mingoia, Aída Nelly García-Argáez, Riccardo Delisi, Annamaria Martorana, Lisa Dalla Via
Due to the scarce biological profile, the pyrazolo[1,2-a]benzo[1,2,3,4]tetrazine-3-one scaffold (PBT), has been recently explored as promising core for potential anticancer candidates. Several suitably decorated derivatives (PBTs) exhibited antiproliferative activity in the low micro-molar range associated with apoptosis induction and cell cycle arrest on S phase. Herein, we selected the most active derivatives and submitted them to further biological explorations in order to deepen the mechanism of action...
September 14, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28905383/leukoencephalopathy-causing-clcn2-mutations-are-associated-with-impaired-cl-channel-function-and-trafficking
#9
Héctor Gaitán-Peñas, Pirjo M Apaja, Tanit Arnedo, Aida Castellanos, Xabier Elorza-Vidal, David Soto, Xavier Gasull, Gergely L Lukacs, Raúl Estévez
Mutations in CLCN2 have been recently identified in patients suffering from a type of leukoencephalopathy involving intramyelinic oedema. Here, we characterised most of these mutations, which reduce the function of the chloride channel ClC-2 and impair its plasma membrane (PM) expression. Detailed biochemical and electrophysiological analyses of the Ala500Val mutation revealed that defective gating and increased cellular and PM turnover contributed to defective A500V-ClC-2 functional expression. Co-expression of the adhesion molecule GlialCAM, which forms a tertiary complex with ClC-2 and megalencephalic leukoencephalopathy with subcortical cyst 1 (MLC1), rescued the functional expression of the mutant by modifying its gating properties...
September 14, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28903782/natural-genetic-variation-of-the-cardiac-transcriptome-in-non-diseased-donors-and-patients-with-dilated-cardiomyopathy
#10
Matthias Heinig, Michiel E Adriaens, Sebastian Schafer, Hanneke W M van Deutekom, Elisabeth M Lodder, James S Ware, Valentin Schneider, Leanne E Felkin, Esther E Creemers, Benjamin Meder, Hugo A Katus, Frank Rühle, Monika Stoll, François Cambien, Eric Villard, Philippe Charron, Andras Varro, Nanette H Bishopric, Alfred L George, Cristobal Dos Remedios, Aida Moreno-Moral, Francesco Pesce, Anja Bauerfeind, Franz Rüschendorf, Carola Rintisch, Enrico Petretto, Paul J Barton, Stuart A Cook, Yigal M Pinto, Connie R Bezzina, Norbert Hubner
BACKGROUND: Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. RESULTS: Here we report the first in-depth survey of heart transcriptome variation using RNA-sequencing in 97 patients with dilated cardiomyopathy and 108 non-diseased controls. We reveal extensive differences of gene expression and splicing between dilated cardiomyopathy patients and controls, affecting known as well as novel dilated cardiomyopathy genes...
September 14, 2017: Genome Biology
https://www.readbyqxmd.com/read/28903312/gnp-gapdh1-22-nanovaccines-prevent-neonatal-listeriosis-by-blocking-microglial-apoptosis-and-bacterial-dissemination
#11
Ricardo Calderon-Gonzalez, Elisabet Frande-Cabanes, Hector Teran-Navarro, José María Marimon, Javier Freire, David Salcines-Cuevas, M Carmen Fariñas, Claudia Onzalez-Rico, Marco Marradi, Isabel Garcia, Mirian Alkorta-Gurrutxaga, Aida San Nicolas-Gomez, Ana Castañeda-Sampedro, Sonsoles Yañez-Diaz, Soledad Penades, Carmen Punzon, Javier Gomez-Roman, Fernando Rivera, Manuel Fresno, Carmen Alvarez-Dominguez
Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28898618/-klebsiella-pneumoniae-from-k1-and-hypervirulent-clone-st23-first-documented-case-in-portugal
#12
Aida Pereira, Tiago Petrucci, Maria João Simões
The hypervirulent K1 serotype Klebsiella pneumoniae is responsible for a new invasive syndrome, typically associated to hepatic abscesses with extra-hepatic complications. Initially described in Taiwan, it has significantly spread to several Asian countries and more recently to Europe and North America, thus constituting an emerging and global problem. The authors describe a case report of a 64-years-old portuguese caucasian woman without any previous diseases or epidemiological risk factors such as trips or contact with Asian products or population, diagnosed with a pyogenic liver abscess with pleural effusion caused by this hyper-virulent strain...
June 30, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28898425/response-of-porcine-epithelial-rests-of-malassez-to-stimulation-by-interleukin-6
#13
R Sako, F Kobayashi, N Aida, M Furusawa, T Muramatsu
AIM: To investigate the proliferation and migration of Epithelial cell rests of Malassez (ERM) after stimulation with IL-6. METHODOLOGY: Porcine-derived ERM were seeded on Dulbecco's modified Eagle's Medium and IL-6 (100 pg/mL) was incorporated into the culture medium. The WST-1 assay was performed to evaluate cell proliferation, and absorption was measured at 450 nm. A wound healing assay and immunofluorescence assay for integrin α3 were conducted in order to investigate migration...
September 12, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28895706/-neonatal-renal-abscess-a-diagnostic-and-therapeutic-challenge-a-clinical-case
#14
Sebastián Argañaraz Gonçalves, Enrique Casanueva, Silvia Filipis, Carla Gandini, M Vanesa Rodríguez, Adriana Santiago, Aída Vázquez, Roberto Vagni
Renal abscess is a rare disease in newborn, but severe consequences can occur: sepsis with high mortality, renal scar formation and risk of chronic renal failure. A neonate with unilateral renal abscess due to Staphylococcus aureus is reported, with septicemia, with no other suppurative focus, nor with urinary malformation, with good clinical evolution with intravenous antibiotics and without surgical treatment, but with renal scars sequel. From this case, the strategies of diagnosis, treatment and followup of the renal abscess in a neonate are analyzed, emphasizing the early diagnosis to avoid renal scars...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28895047/biochemical-hematological-and-pathological-related-healing-effects-of-elaeagnus-angustifolia-hydroalcoholic-extract-in-5-fluorouracil-induced-oral-mucositis-in-male-golden-hamster
#15
Omid Koohi-Hosseinabadi, Zahra Ranjbar, Masood Sepehrimanesh, Azadeh AndisheTadbir, Seyedeh Leila Poorbaghi, Hajar Bahranifard, Nader Tanideh, Maryam Koohi-Hosseinabadi, Aida Iraji
Oral mucositis (OM) is one of the cancer chemotherapy-related side effects which can affect the quality of life of affected patients. This study was designed to investigate the healing effect of Elaeagnus angustifolia in 5-flurouracil (5-FU)-induced OM in golden hamster. Fifty-six adult male golden hamsters received three intraperitoneal injections of 5-FU at a dose of 60 mg/kg on days 0, 5, and 10. The cheek pouch mucosa was scratched superficially under local anesthesia. Then, two horizontal scratches were made across the everted cheek pouch on days 3 and 4...
September 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28893792/influence-of-mechanical-ventilation-on-vancomycin-pharmacokinetics-administered-by-continuous-infusion-in-critically-ill-patients
#16
Susanna Edith Medellín-Garibay, Silvia Romano-Moreno, Pilar Tejedor-Prado, Noelia Rubio-Álvaro, Aida Rueda-Naharro, Miguel Angel Blasco-Navalpotro, Benito García, Emilia Barcia
Pathophysiological changes involved on drug disposition in critically ill patients, should be considered on the dosing optimization of vancomycin administered by continuous infusion, and certain strategies must be applied to reach therapeutic targets on the first day of treatment. The aim of this study was to develop a population pharmacokinetic model of vancomycin to determine clinical covariates, including mechanical ventilation, that influence the wide variability of this antimicrobial. Vancomycin plasma concentrations from 54 critically ill patients were simultaneously analyzed by population pharmacokinetic approach...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28884590/galacto-oligosaccharides-ameliorate-dysbiotic-bifidobacteriaceae-decline-in-japanese-patients-with-type-2-diabetes
#17
M Gonai, A Shigehisa, I Kigawa, K Kurasaki, O Chonan, T Matsuki, Y Yoshida, M Aida, K Hamano, Y Terauchi
Gut microbiota affects the host's metabolism, and it is suggested that there are differences in gut microbiota composition between patients with type 2 diabetes and healthy individuals. Additionally, dysbiosis may increase the concentration of lipopolysaccharides (LPS), causing metabolic endotoxemia, which induces impaired glucose tolerance. Several studies have reported relationships between metabolic diseases and the gut microbiota; and prebiotics, such as oligosaccharides, are commonly consumed to regulate gut microbiotas in healthy individuals...
September 8, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28883405/modeling-a-linkage-between-blood-transcriptional-expression-and-activity-in-brain-regions-to-infer-the-phenotype-of-schizophrenia-patients
#18
El Chérif Ibrahim, Vincent Guillemot, Magali Comte, Arthur Tenenhaus, Xavier Yves Zendjidjian, Aida Cancel, Raoul Belzeaux, Florence Sauvanaud, Olivier Blin, Vincent Frouin, Eric Fakra
Hundreds of genetic loci participate to schizophrenia liability. It is also known that impaired cerebral connectivity is directly related to the cognitive and affective disturbances in schizophrenia. How genetic susceptibility and brain neural networks interact to specify a pathological phenotype in schizophrenia remains elusive. Imaging genetics, highlighting brain variations, has proven effective to establish links between vulnerability loci and associated clinical traits. As previous imaging genetics works in schizophrenia have essentially focused on structural DNA variants, these findings could be blurred by epigenetic mechanisms taking place during gene expression...
September 7, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28880870/c1-inactivator-is-upregulated-in-glioblastoma
#19
Karolina Förnvik, Aida Maddahi, Oscar Persson, Kurt Osther, Leif G Salford, Henrietta Nittby Redebrandt
BACKGROUND: Glioblastoma is the most common and aggressive type of primary brain tumor in adults. A key problem is the capacity of glioma cells to inactivate the body's immune response. The complement system acts as a functional bridge between the innate and adaptive immune response. Still, the role of the complement system has almost been forgotten in glioma research. In our present study, we hypothesize that C1 inactivator (C1-IA) is upregulated in astrocytoma grade IV, and that its inhibition of the complement system has beneficial effects upon survival...
2017: PloS One
https://www.readbyqxmd.com/read/28869458/clinical-significance-of-factor-v-leiden-and-prothrombin-g20210a-mutations-in-cerebral-venous-thrombosis-comparison-with-arterial-ischemic-stroke
#20
Aida Beye, Gerhard Pindur
Cerebrovascular diseases are considered in a different way concerning their etiology with regard to arterial and venous occlusion. The role of thrombophilia in this context remains undetermined. For this reason, a case-control study was conducted including a total of 202 patients (154 females, 48 males) aged from 18 to 76 years (mean: 39.8 years) suffering either from cerebral sinus venous thrombosis (n = 101) or from arterial ischemic stroke (n = 101). Study groups were evaluated on the basis of age- and gender-matched pairs...
August 28, 2017: Clinical Hemorheology and Microcirculation
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