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https://www.readbyqxmd.com/read/28228489/age-dependent-shift-in-macrophage-polarisation-causes-inflammation-mediated-degeneration-of-enteric-nervous-system
#1
Laren Becker, Linh Nguyen, Jaspreet Gill, Subhash Kulkarni, Pankaj Jay Pasricha, Aida Habtezion
OBJECTIVE: The enteric nervous system (ENS) undergoes neuronal loss and degenerative changes with age. The cause of this neurodegeneration is poorly understood. Muscularis macrophages residing in close proximity to enteric ganglia maintain neuromuscular function via direct crosstalk with enteric neurons and have been implicated in the pathogenesis of GI motility disorders like gastroparesis and postoperative ileus. The aim of this study was to assess whether ageing causes alterations in macrophage phenotype that contributes to age-related degeneration of the ENS...
February 21, 2017: Gut
https://www.readbyqxmd.com/read/28227619/characterizing-graphene-modified-electrodes-for-interfacing-with-arduino%C3%A2-based-devices
#2
Farrah Aida Arris, Mohamad Hafiz Ithnin, Wan Wardatul Amani Wan Salim, Farrah Aida Arris, Mohamad Hafiz Ithnin, Wan Wardatul Amani Wan Salim, Mohamad Hafiz Ithnin, Wan Wardatul Amani Wan Salim, Farrah Aida Arris
Portable low-cost platform and sensing systems for identification and quantitative measurement are in high demand for various environmental monitoring applications, especially in field work. Quantifying parameters in the field requires both minimal sample handling and a device capable of performing measurements with high sensitivity and stability. Furthermore, the one-device-fits-all concept is useful for continuous monitoring of multiple parameters. Miniaturization of devices can be achieved by introducing graphene as part of the transducer in an electrochemical sensor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225184/bis-picolinamide-ruthenium-iii-dihalide-complexes-dichloride-to-diiodide-exchange-generates-single-trans-isomers-with-high-potency-and-cancer-cell-selectivity
#3
Aida M Basri, Rianne M Lord, Simon J Allison, Andrea Rodríguez-Bárzano, Stephanie J Lucas, Felix D Janeway, Helena J Shepherd, Christopher M Pask, Roger M Phillips, Patrick Columba McGowan
A library of new bis-picolinamide ruthenium(III) dihalide complexes of the type RuX2L2 (X = Cl or I and L = picolinamide) have been synthesized and characterized. They exhibit different picolinamide ligand binding modes, whereby one ligand is bound (N,N) and the other bound (N,O). Structural studies reveal a mixture of cis and trans isomers for the RuCl2L2 complexes but upon a halide exchange reaction to RuI2L2, only single trans isomers are present. High cytotoxic activity against human cancer cell lines was observed, with potencies for some complexes similar to or better than cisplatin...
February 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28223833/autoimmune-atrophic-gastritis-current-perspectives
#4
REVIEW
Artem Minalyan, Jihane N Benhammou, Aida Artashesyan, Michael S Lewis, Joseph R Pisegna
At present there is no universally accepted classification for gastritis. The first successful classification (The Sydney System) that is still commonly used by medical professionals was first introduced by Misiewicz et al in Sydney in 1990. In fact, it was the first detailed classification after the discovery of Helicobacter pylori by Warren and Marshall in 1982. In 1994, the Updated Sydney System was proposed during the International Workshop on the Histopathology of Gastritis followed by the publication in The American Journal of Surgical Pathology by Dixon et al...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28220662/jumping-crystals-of-pyrene-tweezers-crystal-to-crystal-transition-involving-%C3%AF-%C3%AF-to-ch-%C3%AF-assembly-mode-switching
#5
Yoshiki Shibuya, Yoshimitsu Itoh, Takuzo Aida
Crystals of pyrene tweezers 1 with interdigitating pyrenyl blades jump vigorously at around 160 °C. Single-crystal X-ray diffraction analysis before jumping revealed the presence of a "pyrene tetrad" in the crystal lattice, where four pyrenyl blades are π-stacked on top of each other. Upon heating the crystal to induce the jumping event, inner two pyrenyl blades in the "pyrene tetrad" probably rotate to switch off their π-stacking interaction with the neighboring outer pyrenyl blades and form new CH-π bonds...
February 21, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28219812/detection-and-molecular-diversity-of-giardia-duodenalis-and-cryptosporidium-spp-in-sheltered-dogs-and-cats-in-northern-spain
#6
Horacio Gil, Lourdes Cano, Aida de Lucio, Begoña Bailo, Marta Hernández de Mingo, Guillermo A Cardona, José A Fernández-Basterra, Juan Aramburu-Aguirre, Nuria López-Molina, David Carmena
Domestic dogs and cats may act as natural reservoirs of a large number of zoonotic pathogens, including the enteric parasites Giardia duodenalis and Cryptosporidium spp., the most relevant protozoan species causing gastrointestinal disease worldwide. A cross-sectional epidemiological study aiming to assess the prevalence and molecular diversity of G. duodenalis and Cryptosporidium spp. was conducted in an animal rescue centre in the province of Álava (Northern Spain). A total of 194 and 65 faecal dropping samples from individual dogs and cats, respectively, were collected between November 2013 and June 2016...
February 17, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28219025/mortality-in-individuals-with-disruptive-behavior-disorders-diagnosed-by-specialist-services-a-nationwide-cohort-study
#7
James G Scott, Marianne Giørtz Pedersen, Holly E Erskine, Aida Bikic, Ditte Demontis, John J McGrath, Søren Dalsgaard
Disruptive behavior disorders (DBDs), inclusive of oppositional defiant disorder (ODD) and conduct disorder (CD), are associated with outcomes likely to increase risk of mortality. Using Danish National Registers, a total of 1.92 million individuals including 9495 individuals with DBDs diagnosed by specialist services were followed from their first birthday to 2013. Those with and without DBDs were compared using mortality rate ratios (MRRs) estimated using Poisson regression and adjusted for calendar period, age, sex, family history of psychiatric disorders, maternal age at time of birth, paternal age at time of birth, parental education status, and parental employment status...
February 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28216168/assessment-of-dietary-intake-of-10-intense-sweeteners-by-the-italian-population
#8
Cinzia Le Donne, Lorenza Mistura, Séverine Goscinny, Steven Janvier, Koenraad Cuypers, Laura D'Addezio, Stefania Sette, Giovina Catasta, Marika Ferrari, Raffaela Piccinelli, Joris Van Loco, Aida Turrini
The aim of the present study was to monitor the consumption of foods containing intense sweeteners present on the Italian food market and to investigate whether the Italian general population (aged >3-65+) was at risk for exceeding the Acceptable Daily Intake (ADI) of 10 intense sweeteners. A food label survey was performed in Rome (Italy), using market share data to identify the brands more representative of the market. A sample of 326 foods (table-top sweeteners included), beverages and food supplements containing intense sweeteners was collected and analyzed in order to establish the concentration levels...
February 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28215875/occurrence-and-molecular-genotyping-of-giardia-duodenalis-and-cryptosporidium-spp-in-wild-mesocarnivores-in-spain
#9
Marta Mateo, Marta Hernández de Mingo, Aida de Lucio, Lucía Morales, Ana Balseiro, Alberto Espí, Marta Barral, José Francisco Lima Barbero, Miguel Ángel Habela, José L Fernández-García, Rafael Calero Bernal, Pamela C Köster, Guillermo A Cardona, David Carmena
There is a surprisingly scarce amount of epidemiological and molecular data on the prevalence, frequency, and diversity of the intestinal protozoan parasites Giardia duodenalis and Cryptosporidium spp. in wildlife in general and mesocarnivore species in particular. Consequently, the extent of the cyst/oocyst environmental contamination attributable to these wild host species and their potential implications for public veterinary health remain largely unknown. In this molecular epidemiological survey a total of 193 individual faecal samples from badgers (Meles meles, n=70), ferrets (Mustela putorius furo, n=2), genets (Genetta genetta, n=6), Iberian lynxes (Lynx pardinus, n=6), beech martens (Martes foina, n=8), mongooses (Herpestes ichneumon, n=2), otters (Lutra lutra, n=2), polecats (Mustela putorius, n=2), red foxes (Vulpes vulpes, n=87), wildcats (Felis silvestris, n=2), and wolves (Canis lupus, n=6) were obtained from road-killed, hunted, and accidentally found carcasses, and from camera-trap surveys or animals entering rescue shelters, during the period December 2003-April 2016...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28215596/sex-specific-respiratory-effects-of-acute-and-chronic-caffeine-administration-in-newborn-rats
#10
REVIEW
Hayet Kouchi, NagaPraveena Uppari, Vincent Joseph, Aida Bairam
Caffeine is widely used for the treatment of apnea of prematurity (AoP) but whether this effect varies with sex is unknown. To shed some light on this question, we present a summary of data obtained on the effects of caffeine on the respiratory chemoreflexes and apnea frequency in 1- and 12-days old male and female rats. Caffeine was either administered as a single acute injection (10mg/kg, i.p.) or for 10 consecutive days (7.5mg/kg/day between 3-12days of life by gavage, simulating its clinical use). Acute caffeine had little effects on breathing in 1-day old male and female rats...
February 16, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28215252/can-sleep-disturbance-influence-changes-in-mental-health-status-longitudinal-research-evidence-from-ageing-studies-in-england-and-japan
#11
N Cable, T Chandola, J Aida, M Sekine, G Netuveli
BACKGROUND: Little is known about the role of sleep disturbance in relation to changes in depressive states. We used data obtained from the participants aged 65 and over in the English Longitudinal Study of Ageing (ELSA, waves four and five, N = 3108) and the Japan Gerontological Evaluation Study (JAGES, 2010 and 2013 sweeps, N = 7527) to examine whether sleep disturbance is longitudinally associated with older adults' patterns of depressive states. METHODS: We created four patterns of depressive states (non-case, recovered, onset, repeatedly depressive) by combining responses to the measures (scoring four or more on seven items from the Center for Epidemiological Studies Depression Scale for the ELSA participants and scoring five or more for the Geriatric Depression Scale-15 for the JAGES participants) obtained at the baseline and follow-up...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28213779/adenoid-bacterial-colonization-in-a-paediatric-population
#12
João Subtil, João Carlos Rodrigues, Lúcia Reis, Luís Freitas, Joana Filipe, Alberto Santos, Carlos Macor, Aida Duarte, Luisa Jordao
Adenoids play a key role in both respiratory and ear infection in children. It has also been shown that adenoidectomy improves these symptoms in this population. The main goal of the present study was to evaluate adenoid bacterial colonization and document a possible relation with infectious respiratory disease. A prospective observational study was designed to evaluate the proposed hypothesis in a paediatric population submitted to adenoidectomy by either infectious or non-infectious indications and compare these two cohorts...
February 18, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28213383/development-of-a-direct-observation-of-procedural-skills-rubric-for-fourth-year-pharmacy-students-in-ambulatory-care-rotations
#13
Sara J Linedecker, Jamie Barner, Jennifer Ridings-Myhra, Aida Garza, Debra Lopez, William McIntyre
PURPOSE: The development and implementation of a pilot program requiring direct observation of procedural skills (DOPS) assessments of fourth-year pharmacy students during ambulatory care rotations are described. METHODS: All fourth-year pharmacy students at the University of Texas at Austin College of Pharmacy who engaged in a required advanced pharmacy practice experience (APPE) in ambulatory care during the period January-May 2015 participated in a DOPS pilot program...
March 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28212574/the-combined-action-of-mast-cell-chymase-tryptase-and-carboxypeptidase-a3-protects-against-melanoma-colonization-of-the-lung
#14
Mirjana Grujic, Aida Paivandy, Ann-Marie Gustafson, Allan R Thomsen, Helena Öhrvik, Gunnar Pejler
Mast cell secretory granules are densely packed with various bioactive mediators including proteases of chymase, tryptase and CPA3 type. Previous studies have indicated that mast cells can affect the outcome of melanoma but the contribution of the mast cell granule proteases to such effects has not been clear. Here we addressed this issue by assessing mice lacking either the chymase Mcpt4, the tryptase Mcpt6 or carboxypeptidase A3 (Cpa3), as well as mice simultaneously lacking all three proteases, in a model of melanoma dissemination from blood to the lung...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28210453/surgical-treatment-vs-conservative-treatment-in-intravenous-bisphosphonate-related-osteonecrosis-of-the-jaws-systematic-review
#15
REVIEW
Aida Comas-Calonge, Rui Figueiredo, Cosme Gay-Escoda
AIMS: To determine the success rates of the surgical and non-surgical treatments in the management of bisphosphonate-related osteonecrosis of the jaws (BRONJ). MATERIAL AND METHODS: A systematic review of the literature was made. A PubMed Medline database search was performed in order to include clinical studies published in English,between2004 and 2014 with the following key-words: "BRONJ AND treatment" and "NOT osteoporosis". The following data was gathered: authors, title, year of publication, aim of study, level of evidence, sample size, treatment performed, treatment outcomes and follow-up...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28205117/a-randomized-comparison-between-costoclavicular-and-paracoracoid-ultrasound-guided-infraclavicular-block-for-upper-limb-surgery
#16
Prangmalee Leurcharusmee, Maria Francisca Elgueta, Worakamol Tiyaprasertkul, Thitipan Sotthisopha, Artid Samerchua, Aida Gordon, Julian Aliste, Roderick J Finlayson, De Q H Tran
BACKGROUND: This two-centre randomized trial compared costoclavicular and paracoracoid ultrasound-guided infraclavicular brachial plexus block in patients undergoing upper limb surgery. We hypothesized that both techniques would result in similar onset times and designed the study as an equivalence trial. METHODS: Ninety patients undergoing upper limb surgery at or distal to the elbow were randomly allocated to receive a costoclavicular (n = 45) or paracoracoid (n = 45) ultrasound-guided infraclavicular brachial plexus block...
February 15, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28199739/obesity-in-children-with-congenital-adrenal-hyperplasia-in-the-minnesota-cohort-importance-of-adjusting-body-mass-index-for-height-age
#17
Kyriakie Sarafoglou, Gregory P Forlenza, O Yaw Addo, Jennifer Kyllo, Aida Lteif, P C Hindmarsh, Anna Petryk, Maria Teresa Gonzalez-Bolanos, Bradley S Miller, William Thomas
OBJECTIVES: To evaluate obesity and overweight in children with congenital adrenal hyperplasia (CAH), and associations with glucocorticoids, fludrocortisone and disease control. Adjusting body mass index for-height-age (BMIHA ) percentile is proposed to correct misclassification of obese/overweight status in CAH children with advanced bone age and tall-for-age stature. DESIGN: Longitudinal. PATIENTS: 194 children with CAH seen from 1970-2013: 124 salt-wasting (SW); 70 simple-virilizing (SV); 102 females...
February 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28197106/inhibition-of-intermediate-conductance-calcium-activated-k-channel-kca3-1-and-fibroblast-mitogenesis-by-%C3%AE-linolenic-acid-and-alterations-of-channel-expression-in-the-lysosomal-storage-disorders-fabry-disease-and-niemann-pick-c
#18
Aida Oliván-Viguera, Javier Lozano-Gerona, Laura López de Frutos, Jorge J Cebolla, Pilar Irún, Edgar Abarca-Lachen, Ana J García-Malinis, Ángel Luis García-Otín, Yolanda Gilaberte, Pilar Giraldo, Ralf Köhler
The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K(+)-efflux, cell volume, and membrane hyperpolarization-driven calcium-entry. Recent studies suggest modulation of KCa3.1 by omega-3 fatty acids as negative modulators and impaired KCa3.1 functions in the inherited lysosomal storage disorder (LSD), Fabry disease (FD). In the first part of present study, we characterize KCa3.1 in murine and human fibroblasts and test the impact of omega-3 fatty acids on fibroblast proliferation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28196020/the-prevalence-and-clinicopathological-characteristics-of-high-grade-pancreatic-intraepithelial-neoplasia-autopsy-study-evaluating-the-entire-pancreatic-parenchyma
#19
Yoko Matsuda, Toru Furukawa, Shinichi Yachida, Makoto Nishimura, Atsuko Seki, Keisuke Nonaka, Junko Aida, Kaiyo Takubo, Toshiyuki Ishiwata, Wataru Kimura, Tomio Arai, Mari Mino-Kenudson
OBJECTIVE: We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS: We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenocarcinoma and/or intraductal papillary mucinous neoplasm (mean age, 80.5 years) by submitting the entire pancreas for microscopic examination. RESULTS: PanIN-3 was found in 4% of examined cases, whereas PanIN-1 and PanIN-2 were present in 77% and 28%, respectively...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28193484/clearance-of-cardiac-troponin-t-with-and-without-kidney-function
#20
Vincent Fridén, Karin Starnberg, Aida Muslimovic, Sven-Erik Ricksten, Christian Bjurman, Niklas Forsgard, Anna Wickman, Ola Hammarsten
OBJECTIVE: The extent of kidney-dependent clearance of the cardiac damage biomarker cardiac troponin T (cTnT) is not known. METHODS AND RESULTS: We examined clearance of cTnT after injection of heart extracts in rats with or without clamped kidney vessels. The extent of degradation of cTnT to fragments able to pass the glomerular membrane and the kidney extraction index of cTnT was examined in human subjects. After a bolus injection of rat cardiac extract, simulating a large myocardial infarction, there was no significant difference in clearance of cTnT with or without kidney function...
February 10, 2017: Clinical Biochemistry
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