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https://www.readbyqxmd.com/read/29129538/pneumonia-in-the-tropics-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#1
REVIEW
Mohd Basri Mat Nor, Guy A Richards, Steve McGloughlin, Pravin R Amin
The aetiology of community acquired pneumonia varies according to the region in which it is acquired. This review discusses those causes of CAP that occur in the tropics and might not be readily recognizable when transplanted to other sites. Various forms of pneumonia including the viral causes such as influenza (seasonal and avian varieties), the coronaviruses and the Hantavirus as well as bacterial causes, specifically the pneumonic form of Yersinia pestis and melioidosis are discussed.
November 3, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29111189/clinical-and-environmental-isolates-of-burkholderia-pseudomallei-from-brazil-genotyping-and-detection-of-virulence-gene
#2
Tereza de Jesus Pinheiro Gomes Bandeira, Débora de Souza Collares Maia Castelo-Branco, Marcos Fábio Gadelha Rocha, Rossana de Aguiar Cordeiro, Crister José Ocadaque, Manoel de Araújo Neto Paiva, Raimunda Sâmia Nogueira Brilhante, José Júlio Costa Sidrim
OBJECTIVE: To evaluate the genetic diversity of clinical and environmental isolates of Burkholderia pseudomallei (B. pseudomallei) recovered in Ceará, Brazil, and screen these isolates for the presence of type three secretion system virulence gene. METHODS: Nineteen B. pseudomallei isolates (9 from clinical cases and 10 from soils) were analyzed. Random amplified polymorphic DNA was performed with primers OPQ-2, OPQ-4 and OPQ-16 to evaluate the genetic diversity, and type three secretion system gene was detected through polymerase chain reaction...
October 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29109172/development-of-subunit-vaccines-that-provide-high-level-protection-and-sterilizing-immunity-against-acute-inhalational-melioidosis
#3
Mary N Burtnick, Teresa L Shaffer, Brittany N Ross, Laura A Muruato, Elena Sbrana, David DeShazer, Alfredo G Torres, Paul J Brett
Burkholderia pseudomallei, the etiologic agent of melioidosis, causes severe disease in humans and animals. Diagnosis and treatment of melioidosis can be challenging and no licensed vaccines currently exist. Several studies have shown that this pathogen expresses a variety of structurally conserved protective antigens that include cell-surface polysaccharides and cell-associated/-secreted proteins. Based on this, such antigens have become important components of the subunit vaccine candidates that we are currently developing...
November 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29098887/comparison-of-the-amine-amino-acid-activation-profiles-of-the-%C3%AE-and-%C3%AE-carbonic-anhydrases-from-the-pathogenic-bacterium-burkholderia-pseudomallei
#4
COMPARATIVE STUDY
Daniela Vullo, Sonia Del Prete, Sameh M Osman, Fatmah A S Alasmary, Zeid AlOthman, William A Donald, Clemente Capasso, Claudiu T Supuran
The β-class carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium Burkholderia pseudomallei, BpsCAβ, that is responsible for the tropical disease melioidosis was investigated for its activation with natural and non-natural amino acids and amines. Previously, the γ-CA from this bacterium has been investigated with the same library of 19 amines/amino acids, which show very potent activating effects on both enzymes. The most effective BpsCAβ activators were L- and D-DOPA, L- and D-Trp, L-Tyr, 4-amino-L-Phe, histamine, dopamine, serotonin, 2-pyridyl-methylamine, 1-(2-aminoethyl)-piperazine and L-adrenaline with KAs of 0...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29092705/melioidosis-in-far-north-queensland-is-not-correlated-with-severe-weather-events
#5
James D Stewart, Simon Smith, Josh Hanson
No abstract text is available yet for this article.
November 6, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29074366/production-and-evaluation-of-recombinant-burkholderia-pseudomallei-groel-and-ompa-proteins-for-serodiagnosis-of-melioidosis
#6
Kanyanan Kritsiriwuthinan, Sumet Wajanarogana, Kantima Choosang, Jetsada Homsian, Sukritta Rerkthanom
Melioidosis is a bacterial infectious disease caused by Burkholderia pseudomallei (B. pseudomallei). The variable clinical manifestations of this disease make its diagnosis difficult. The gold standard strategy for diagnosis is bacterial culture and identification, which is time-consuming and often too late for early medical intervention. Therefore, a rapid and accurate diagnosis of melioidosis is needed for effective treatment. This study aimed to produce and evaluate two purified B. pseudomallei recombinant proteins (rGroEL and rOmpA) as potential antigens for melioidosis diagnosis by ELISA...
October 23, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29054959/honeycomb-and-necklace-signs-in-liver-abscesses-secondary-to-melioidosis
#7
Sidney Ching Liang Ong, Mina Mustafa Mahmood Alemam, Nor Aniza Zakaria, Nur Azidawati Abdul Halim
Melioidosis is endemic in Southeast Asia and tropical Australia with varying clinical features from benign skin lesions to fatal septicaemia. Imaging plays an important role in evaluation of the melioid liver abscesses. A 45-year-old man with underlying diabetes presented with fever and lethargy for 2 weeks and abdominal pain for 2 days. His liver was enlarged on examination. Blood investigations revealed mild leucocytosis and raised liver enzymes. Ultrasound showed multiple multiloculated hypoechoic lesions throughout the liver and spleen...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29048275/comparison-of-in-house-igm-and-igg-elisas-for-the-serodiagnosis-of-melioidosis-in-malaysia
#8
Shirley Yi Fen Hii, Noor Azila Ali, Norazah Ahmad, Fairuz Amran
Melioidosis is an endemic infectious disease in Southeast Asia and northern Australia, caused by Burkholderia pseudomallei. However, the incidence rate in Malaysia is not well documented. The high mortality rate and broad range of clinical presentations require rapid and accurate diagnosis for appropriate treatment. This study compared the efficacy of in-house IgM and IgG ELISA methods using a local B. pseudomallei strain. The diagnostic accuracy of the in-house IgG ELISA was better than that of the IgM ELISA: sensitivity (IgG: 84...
October 19, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29046753/melioidosis-the-great-mimicker
#9
Mandeep Singh, Mehvish Mahmood
Melioidosis is an infectious disease endemic in Northern Australia and South East Asia. It is associated with high degrees of morbidity and mortality. On average, around five cases are diagnosed annually in the USA. Diagnosis remains a challenge, as it mimics many other conditions, especially tuberculosis, hence its other name, the 'great mimicker.' The present case involves a recent traveler to the Philippines, who presented with episodic fevers and weight loss to his primary care physician. Blood cultures ordered grew Burkholderia pseudomallei...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29026657/whole-genome-sequencing-to-investigate-a-non-clonal-melioidosis-cluster-on-a-remote-australian-island
#10
Derek S Sarovich, Stephanie N J Chapple, Erin P Price, Mark Mayo, Matthew T G Holden, Sharon J Peacock, Bart J Currie
Melioidosis is a tropical disease caused by the bacterium Burkholderia pseudomallei. Outbreaks are uncommon and can generally be attributed to a single point source and strain. We used whole-genome sequencing to analyse B. pseudomallei isolates collected from an historical 2-year long case cluster that occurred in a remote northern Australian indigenous island community, where infections were previously linked to a contaminated communal water supply. We analysed the genome-wide relatedness of the two most common multilocus sequence types (STs) involved in the outbreak, STs 125 and 126...
August 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29024844/structural-characterisation-of-the-capsular-polysaccharide-expressed-by-burkholderia-thailandensis-strain-e555-wbii-pknock-kmr-and-assessment-of-the-significance-of-the-2-o-acetyl-group-in-immune-protection
#11
Marc Bayliss, Matthew I Donaldson, Sergey A Nepogodiev, Giulia Pergolizzi, Andrew E Scott, Nicholas J Harmer, Robert A Field, Joann L Prior
Burkholderia pseudomallei and its close relative B. mallei are human pathogens that are classified as Tier 1 bio-threat agents. Both organisms have previously been shown to constitutively produce a capsular polysaccharide (CPS) that is both a virulence determinant and protective antigen. Extraction and purification of CPS for use as a potential vaccine candidate requires containment level 3 laboratories which is expensive and time-consuming. B. thailandensis strain E555 is closely related to B. pseudomallei and B...
November 27, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29016340/presence-of-burkholderia-pseudomallei-in-soil-and-paddy-rice-water-in-a-rice-field-in-northeast-thailand-but-not-in-air-and-rainwater
#12
Catherine E L Ong, Gumphol Wongsuvan, Janet S W Chew, Tan Yian Kim, Low Hwee Teng, Premjit Amornchai, Vanaporn Wuthiekanun, Nicholas P J Day, Sharon J Peacock, Tan Yoke Cheng, Eric P H Yap, Direk Limmathurotsakul
Environmental Burkholderia pseudomallei has been postulated to be aerosolized during ploughing and heavy rain, and could result in inhalational melioidosis. Here, we determined the presence of B. pseudomallei in soil, paddy field water (PFW), air, and rainwater samples in a single rice paddy field in Ubon Ratchathani, northeast Thailand. In 2012, we collected 100 soil samples during the dry season, 10 PFW samples during the monsoon season, 77 air samples during ploughing (N = 31) and heavy rains (N = 46), and 60 rainwater samples during 12 rain events...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016319/clinical-epidemiology-of-septic-arthritis-caused-by-burkholderia-pseudomallei-and-other-bacterial-pathogens-in-northeast-thailand
#13
Prapit Teparrukkul, Jiraphorn Nilsakul, Susanna Dunachie, Direk Limmathurotsakul
Septic arthritis is a medical emergency, and if not treated appropriately, it can be associated with high morbidity and mortality. Melioidosis, a serious infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is highly endemic in South and Southeast Asia and northern Australia. We reviewed the medical charts of adult patients admitted with bacterial septic arthritis at Sunpasitthiprasong Hospital, Ubon Ratchathani, northeast Thailand from January 2012 to December 2014. Bacterial septic arthritis was defined as one or more hot swollen joints with isolation of a pathogenic organism from an affected joint or from blood...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016313/case-report-fatal-pediatric-melioidosis-despite-optimal-intensive-care
#14
Alice Young, Catherine Tacon, Simon Smith, Ben Reeves, Greg Wiseman, Josh Hanson
With prompt administration of appropriate antimicrobial therapy and access to modern intensive care support, fatal pediatric melioidosis is very unusual. We describe cases of two children in whom the possibility of melioidosis was recognized relatively early, but who died of the disease, despite receiving optimal supportive care. We discuss the resulting implications for bacterial virulence factors in disease pathogenesis.
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994855/melioidos-%C3%A2-en-viktig-diagnos-vid-sv%C3%A3-r-sjukdom-efter-utlandsresa
#15
Åsa Gylfe, Sara Cajander, Tara Wahab, Martin Angelin
Melioidosis, an important diagnosis in the severely ill traveler Melioidosis is a common tropical infection in Southeast Asia and is caused by the highly pathogenic soil bacterium Burkholderia pseudomallei. Diagnosis and treatment is often challenging due to variations in clinical presentation, limited antibiotic susceptibility and high risk of recurring infection. In this report, three cases with different clinical presentations are described.
October 9, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28978597/melioidosis-presenting-as-septicaemia-and-facial-nerve-palsy
#16
Tessa Antony, Swathy Moorthy, Anbumani Narayanaswamy, Preetam Arthur
A 43-year-old farmer presented with acute onset pneumonia, septicaemia and peripheral facial nerve palsy (left side). Burkholderia pseudomallei was isolated from the blood culture of the patient. The patient was successfully treated with intravenous meropenem and oral cotrimoxazole for 2 weeks followed by maintenance therapy with cotrimoxazole. The case is reported to increase awareness among the clinicians and microbiologists regarding melioidosis.
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28966500/chromobacterium-violaceum-induced-sepsis-and-multiorgan-dysfunction-resembling-melioidosis-in-an-elderly-diabetic-patient-a-case-report-with-review-of-literature
#17
Sagar Khadanga, Tadepalli Karuna, Dharmendra Dugar, Shakti Prasad Satapathy
An elderly diabetic farmer presented with chronic nonhealing ulcer over the left foot, multiple liver abscesses, and right-sided pleural effusion. The patient developed septicemia and multiorgan failure. The pus grew pigment producing Chromobacterium violaceum. He was treated successfully with ciprofloxacin for a total duration of 15 days. This case is reported for its rare clinical presentation and resemblance with melioidosis. Of the 200 C. violaceum cases reported across the globe, this is the 14(th) case from India and the oldest in the literature...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28965656/effects-of-binge-alcohol-exposure-on-burkholderia-thailandensis-alveolar-macrophage-interaction
#18
Victor Jimenez, Ryan Moreno, Emily Kaufman, Heidie Hornstra, Erik Settles, Bart J Currie, Paul Keim, Fernando P Monroy
Alcohol consumption has diverse and well-documented effects on the human immune system and its ability to defend against infective agents. One example is melioidosis, a disease caused by infection with Burkholderia pseudomallei, which is of public health importance in Southeast Asia and Northern Australia, with an expanding global distribution. While B. pseudomallei infections can occur in healthy humans, binge alcohol use is progressively being recognized as a major risk factor. Although binge alcohol consumption has been considered as a risk factor for the development of melioidosis, no experimental studies have investigated the outcomes of alcohol exposure on Burkholderia spp...
November 2017: Alcohol
https://www.readbyqxmd.com/read/28939855/infection-with-burkholderia-pseudomallei-immune-correlates-of-survival-in-acute-melioidosis
#19
Susanna J Dunachie, Kemajittra Jenjaroen, Catherine J Reynolds, Kathryn J Quigley, Ruhena Sergeant, Manutsanun Sumonwiriya, Panjaporn Chaichana, Suchintana Chumseng, Pitchayanant Ariyaprasert, Patricia Lassaux, Louise Gourlay, Charuporn Promwong, Prapit Teparrukkul, Direk Limmathurotsakul, Nicholas P J Day, Daniel M Altmann, Rosemary J Boyton
Melioidosis, caused by Burkholderia pseudomallei, is a potentially lethal infection with no licensed vaccine. There is little understanding of why some exposed individuals have no symptoms, while others rapidly progress to sepsis and death, or why diabetes confers increased susceptibility. We prospectively recruited a cohort of 183 acute melioidosis patients and 21 control subjects from Northeast Thailand and studied immune parameters in the context of survival status and the presence or absence of diabetes...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934180/notes-from-the-field-travel-associated-melioidosis-and-resulting-laboratory-exposures-united-states-2016
#20
Patrick K Mitchell, Colin Campbell, Martha P Montgomery, Julie Paoline, Christopher Wilbur, Leah Posivak-Khouly, Kristin Garafalo, Mindy Elrod, Lindy Liu, Andre Weltman
In mid-July 2016, a Pennsylvania resident aged 15 years who had recently returned from Thailand was treated by a pediatrician for sore throat, fever, and bilateral thigh abscesses at the sites of mosquito bites (Figure). She had traveled to northeast Thailand with nine other teens as part of an 18-day service-oriented trip run by an Ohio-based youth tour company that arranges travel to Thailand for approximately 500 persons annually. This trip included construction and agricultural activities and recreational mud exposures...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
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