keyword
MENU ▼
Read by QxMD icon Read
search

immunology hiv

keyword
https://www.readbyqxmd.com/read/27907136/immune-activation-and-bacterial-translocation-a-link-between-impaired-immune-recovery-and-frequent-visceral-leishmaniasis-relapses-in-hiv-infected-patients
#1
Maria Luciana Silva-Freitas, Glaucia Fernandes Cota, Talia S Machado-de-Assis, Carmem Giacoia-Gripp, Ana Rabello, Alda M Da-Cruz, Joanna R Santos-Oliveira
The maintenance of chronic immune activation due to leishmaniasis or even due to microbial translocation is associated with immunosenescence and may contribute to frequent relapses. Our aim was to investigate whether patients with HIV-associated visceral leishmaniasis (VL/HIV) who experience a single episode of VL have different immunological behaviors in comparison to those who experience frequent relapses. VL/HIV patients were allocated to non-relapsing (NR, n = 6) and relapsing (R, n = 11) groups and were followed from the active phase of VL up to 12 months post-treatment (mpt)...
2016: PloS One
https://www.readbyqxmd.com/read/27906025/nutritional-status-and-its-effect-on-treatment-outcome-among-hiv-infected-clients-receiving-haart-in-ethiopia-a-cohort-study
#2
Sadikalmahdi Hussen, Tefera Belachew, Nezif Hussien
PURPOSES: The aim of this study was to determine the effects of nutritional status at the start of highly active anti-retroviral therapy on treatment outcomes among HIV/AIDS patients taking HAART at Jimma University Specialized Hospital. METHODS: We performed a retrospective cohort study involving 340 adults who started highly active anti-retroviral therapy. The patients have been clinically followed for 2 years. Data were extracted from paper based medical charts by trained data collectors from January 30 to February 28, 2014 using data collection format...
September 22, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27906016/high-prevalence-of-being-overweight-and-obese-hiv-infected-persons-before-and-after-24%C3%A2-months-on-early-art-in-the-anrs-12136-temprano-trial
#3
Calixte Guehi, Anani Badjé, Delphine Gabillard, Eric Ouattara, Serge Olivier Koulé, Raoul Moh, Didier Ekouevi, Hugues Ahibo, Jean Baptiste N'Takpé, Gérard Kouamé Menan, Nina Deschamps, Jerôme Lecarrou, Serge Eholié, Xavier Anglaret, Christine Danel
BACKGROUND: HIV is usually associated with weight loss. World health Organization (WHO) recommends early antiretroviral (ART) initiation, but data on the progression of body mass index (BMI) in participants initiating early ART in Africa are scarce. METHODS: The Temprano randomized trial was conducted in Abidjan to assess the effectiveness of early ART and Isoniazid (INH) prophylaxis for tuberculosis in HIV-infected persons with high CD4 counts below 800 cells/mm(3) without any indication for starting ART...
February 25, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27902602/sensitivity-and-specificity-of-dried-blood-spots-for-hiv-1-viral-load-quantification-a-laboratory-assessment-of-3-commercial-assays
#4
Pieter Pannus, Maarten Claus, Maria Mercedes Perez Gonzalez, Nathan Ford, Katrien Fransen
The use of dried blood spots (DBS) instead of plasma as a specimen type for HIV-1 viral load (VL) testing facilitates the decentralization of specimen collection and can increase access to VL testing in resource-limited settings. The performance of DBS for VL testing is lower, however, when compared to the gold standard sample type plasma. In this diagnostic accuracy study, we evaluated 3 VL assays with DBS.Participants were recruited between August 2012 and April 2015. Both plasma and DBS specimens were prepared and tested for HIV-1 VL with the Roche CAP/CTM HIV-1 test v2...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27893488/pregnancy-and-hiv-disease-progression-in-an-early-infection-cohort-from-five-african-countries
#5
Kristin M Wall, Wasima Rida, Lisa Haddad, Anatoli Kamali, Etienne Karita, Shabir Lakhi, William Kilembe, Susan Allen, Mubiana Inambao, Annie H Yang, Mary H Latka, Omu Anzala, Eduard J Sanders, Linda-Gail Bekker, Vinodh A Edward, Matt A Price
BACKGROUND: Understanding associations between pregnancy and HIV disease progression is critical to providing appropriate counseling and care to HIV-positive women. METHODS: From 2006-2011, women under age 40 with incident HIV infection were enrolled in an early HIV infection cohort in Kenya, Rwanda, South Africa, Uganda, and Zambia. Time-dependent Cox models evaluated associations between pregnancy and HIV disease progression. Clinical progression was defined as a single CD4 measurement <200 cells/μL, percent CD4 <14%, or category C event, with censoring at antiretroviral (ART) initiation for reasons other than prevention of mother-to-child transmission (PMTCT)...
November 22, 2016: Epidemiology
https://www.readbyqxmd.com/read/27890954/prevalence-of-vitamin-b12-and-folic-acid-deficiency-in-hiv-positive-patients-and-its-association-with-neuropsychiatric-symptoms-and-immunological-response
#6
Prabha M R Adhikari, Mukta N Chowta, John T Ramapuram, Satish Rao, Karthik Udupa, Sahana Devdas Acharya
BACKGROUND: Deficiency of micronutrients is prevalent even before the development of symptoms of HIV disease and is associated with accelerated HIV disease progression. AIMS: This study evaluates the prevalence of folate and Vitamin B12 deficiency in HIV-positive patients with or without tuberculosis (TB) and its association with neuropsychiatric symptoms and immunological response. SETTINGS AND DESIGN: Cross-sectional, observational study in an outpatient setting...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27886201/cryptococcal-meningitis-epidemiology-immunology-diagnosis-and-therapy
#7
REVIEW
Peter R Williamson, Joseph N Jarvis, Anil A Panackal, Matthew C Fisher, Síle F Molloy, Angela Loyse, Thomas S Harrison
HIV-associated cryptococcal meningitis is by far the most common cause of adult meningitis in many areas of the world that have high HIV seroprevalence. In most areas in Sub-Saharan Africa, the incidence of cryptococcal meningitis is not decreasing despite availability of antiretroviral therapy, because of issues of adherence and retention in HIV care. In addition, cryptococcal meningitis in HIV-seronegative individuals is a substantial problem: the risk of cryptococcal infection is increased in transplant recipients and other individuals with defects in cell-mediated immunity, and cryptococcosis is also reported in the apparently immunocompetent...
November 25, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27884153/performance-evaluation-of-the-touchscreen-based-muse%C3%A2-auto-cd4-cd4-single-platform-system-for-cd4-t-cell-numeration-in-absolute-number-and-in-percentage-using-blood-samples-from-children-and-adult-patients-living-in-the-central-african-republic
#8
Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet, Laurent Bélec
BACKGROUND: The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in absolute number and in percentage was evaluated using Central African patients' samples compared against the reference EC IVD-qualified BD FACSCount (Becton-Dickinson, USA) flow cytometer. METHODS: EDTA-blood samples from 124 adults, 10 adolescents, 13 children and 3 infants were tested in parallel at 2 reference laboratories in Bangui...
November 25, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27880897/direct-probing-of-germinal-center-responses-reveals-immunological-features-and-bottlenecks-for-neutralizing-antibody-responses-to-hiv-env-trimer
#9
Colin Havenar-Daughton, Diane G Carnathan, Alba Torrents de la Peña, Matthias Pauthner, Bryan Briney, Samantha M Reiss, Jennifer S Wood, Kirti Kaushik, Marit J van Gils, Sandy L Rosales, Patricia van der Woude, Michela Locci, Khoa M Le, Steven W de Taeye, Devin Sok, Ata Ur Rasheed Mohammed, Jessica Huang, Sanjeev Gumber, AnaPatricia Garcia, Sudhir P Kasturi, Bali Pulendran, John P Moore, Rafi Ahmed, Grégory Seumois, Dennis R Burton, Rogier W Sanders, Guido Silvestri, Shane Crotty
Generating tier 2 HIV-neutralizing antibody (nAb) responses by immunization remains a challenging problem, and the immunological barriers to induction of such responses with Env immunogens remain unclear. Here, some rhesus monkeys developed autologous tier 2 nAbs upon HIV Env trimer immunization (SOSIP.v5.2) whereas others did not. This was not because HIV Env trimers were immunologically silent because all monkeys made similar ELISA-binding antibody responses; the key difference was nAb versus non-nAb responses...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27878102/antiretroviral-naive-and-treated-patients-discrepancies-of-b-cell-subsets-during-the-natural-course-of-human-immunodeficiency-virus-type-1-infection
#10
Olga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Apostolia Margariti, Adamantini Georgiou, Dimitrios Bougiouklis, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis
AIM: To evaluate alterations of memory B cell subpopulations during a 48-wk period in human immunodeficiency virus type 1 (HIV-1) patients. METHODS: Forty-one antiretroviral naïve and 41 treated HIV-1 patients matched for age and duration of HIV infection were recruited. All clinical, epidemiological and laboratory data were recorded or measured. The different B cell subsets were characterized according to their surface markers: Total B cells (CD19(+)), memory B cells (CD19(+)CD27(+), BMCs), resting BMCs (CD19(+)CD27(+)CD21(high), RM), exhausted BMCs (CD19(+)CD21(low)CD27(-), EM), IgM memory B (CD19(+)CD27(+)IgM(high)), isotype-switched BMCs (CD19(+)CD27(+)IgM(-), ITS) and activated BMCs (CD19(+)CD21(low+)CD27(+), AM) at baseline on week 4 and week 48...
November 12, 2016: World Journal of Virology
https://www.readbyqxmd.com/read/27869441/immunology-update-primary-immunodeficiency-diseases
#11
S Paul Starr
There are 264 primary immunodeficiencies (PIDs), most of which are rare. They are caused by complement deficiencies, defects in phagocyte function, impaired T-cell function, and/or impaired B-cell function with antibody deficiencies. Most patients with PIDs will present, at varying ages, with frequent infections. These infections can be common respiratory tract infections such as otitis media or pneumonia, or they can be unusual bacterial, fungal, or parasitic infections. Neonatal screening for severe combined immunodeficiency syndrome, one of the most common and serious PIDs, is now performed in most US states, but many PIDs manifest and are detected after birth...
November 2016: FP Essentials
https://www.readbyqxmd.com/read/27866487/tuberculosis-infection-testing-in-hiv-positive-men-who-have-sex-with-men-from-xi-an-china
#12
H N Xin, X W Li, L Zhang, Z Li, H R Zhang, Y Yang, M F Li, B X Feng, H J Li, L Gao
In individuals with latent tuberculosis (TB) infection, those living with human immunodeficiency virus (HIV) had a 20-37 times higher risk of developing active TB compared to those without HIV infection. Systematic testing and treatment of latent TB infection are priorities in HIV-infected persons. In China, the prevalence of HIV infection in men who have sex with men (MSM) has gradually increased in the past decade. However, the prevalence of TB infection has been studied sparsely in HIV-infected MSM. Hence, we conducted a pilot study in MSM living with HIV infection in Xi'an city to evaluate TB infection status by means of interferon-γ release assay (IGRA)...
November 21, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27865174/maraviroc-in-addition-to-cart-during-primary-hiv-infection-results-from-main-randomized-clinical-trial-and-96-weeks-follow-up
#13
Marco Ripa, Manuela Pogliaghi, Stefania Chiappetta, Silvia Nozza, Alessandro Soria, Giacomo Coppalini, Cristina Rovelli, Giuseppe Tambussi
BACKGROUND: Multi-targeted treatment strategies including maraviroc (MVC) during Primary HIV Infection (PHI) may benefit from the immune-modulatory properties of this CCR5-inhibitor. OBJECTIVES: We conducted a proof-of-concept clinical trial aimed at assessing whether maraviroc in addition of a combination antiretroviral therapy (cART) initiated during PHI would improve immunological and virological parameters. STUDY DESIGN: The MAIN (Maraviroc in HIV Acute INfection) study was a randomized open-label clinical trial (EUDRACT number: 2008-007004-29) which enrolled 29 patients with PHI...
October 31, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27863194/pomalidomide-for-symptomatic-kaposi-s-sarcoma-in-people-with-and-without-hiv-infection-a-phase-i-ii-study
#14
Mark N Polizzotto, Thomas S Uldrick, Kathleen M Wyvill, Karen Aleman, Cody J Peer, Margaret Bevans, Irini Sereti, Frank Maldarelli, Denise Whitby, Vickie Marshall, Priscila H Goncalves, Vikram Khetani, William D Figg, Seth M Steinberg, Jerome B Zeldis, Robert Yarchoan
Purpose Kaposi's sarcoma (KS) is a multicentric tumor caused by Kaposi's sarcoma-associated herpesvirus. Unmet needs include therapies that are oral, anthracycline sparing, and deliverable in resource-limited settings. We evaluated pomalidomide, an oral immune modulatory agent, in patients with symptomatic KS. Methods The primary objectives were to assess tolerability, pharmacokinetics, and activity. Initial dosage level was 5 mg once per day for 21 days per 28-day cycle, with a de-escalated level of 3 mg if not tolerable, and aspirin 81 mg once per day thromboprophylaxis...
December 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27862500/antibodies-to-h1-histone-from-the-sera-of-hiv-infected-patients-recognize-and-catalyze-site-specific-degradation-of-this-histone
#15
Svetlana V Baranova, Pavel S Dmitrienok, Nikita V Ivanisenko, Valentina N Buneva, Georgy A Nevinsky
Histones and their posttranslational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecules when they are released into the extracellular space. Administration of histones to animals leads to systemic inflammatory and toxic responses. Autoantibodies with enzymatic activities (abzymes) are distinctive feature of some autoimmune and viral diseases. Electrophoretically and immunologically homogeneous IgGs containing no canonical enzymes were isolated from sera of human immunodeficiency virus-infected patients by chromatography on several affinity sorbents...
November 10, 2016: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27862491/alarmins-and-central-nervous-system-inflammation-in-hiv-associated-neurological-disorders
#16
M-L Gougeon
In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorders (HAND) persist in infected individuals with adequate immunological and virological status. Risk factors for cognitive impairment include hepatitis C virus co-infection, host genetic factors predisposing to HAND, the early establishment of the virus in the CNS and its persistence under HAART; thus, the CNS is an important reservoir for HIV. Microglial cells are permissive to HIV-1, and NLRP3 inflammasome-associated genes were found expressed in brains of HIV-1-infected persons, contributing to brain disease...
November 16, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27861555/p16ink4a-expression-and-immunologic-aging-in-chronic-hiv-infection
#17
Susan Pereira Ribeiro, Jeffrey M Milush, Edecio Cunha-Neto, Esper G Kallas, Jorge Kalil, Luiz Felipe D Passero, Peter W Hunt, Steven G Deeks, Douglas F Nixon, Devi SenGupta
Chronic HIV infection is characterized by increased immune activation and immunosenescence. p16 INK4a (p16) is a member of the cyclin-dependent kinase antagonist family that inhibits cellular proliferation, and its protein expression increases during normal chronological aging. However, some infectious diseases can increase the expression of this anti-proliferative protein, potentially accelerating immunological aging and dysfunction. In order to investigate the immunological aging in HIV patients, p16 protein expression was evaluated by flow cytometry, in T cell subsets in a cohort of chronically HIV-infected patients on and off ART as well as age-matched healthy controls...
2016: PloS One
https://www.readbyqxmd.com/read/27858912/a-randomized-controlled-clinical-trial-on-the-impact-of-ccr5-blockade-with-maraviroc-in-early-infection-on-t-cell-dynamics
#18
Maile Y Karris, Anya Umlauf, Florin Vaida, Douglas Richman, Susan Little, Davey Smith
BACKGROUND: Initiation of antiretroviral therapy (ART) in early HIV infection demonstrates clinical benefits including enhanced CD4 T-lymphocyte recovery and minimization of the latent HIV reservoir. Whether ART intensification with CCR5 blockade provides additional benefits is unknown. TRIAL DESIGN: This randomized controlled trial evaluated the impact of maraviroc (MVC) intensification in persons starting ART in acute and early HIV (AEH, within 3 months of estimated date of infection)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27853598/the-evolutionary-ecology-of-molecular-replicators
#19
Sean Nee
By reasonable criteria, life on the Earth consists mainly of molecular replicators. These include viruses, transposons, transpovirons, coviruses and many more, with continuous new discoveries like Sputnik Virophage. Their study is inherently multidisciplinary, spanning microbiology, genetics, immunology and evolutionary theory, and the current view is that taking a unified approach has great power and promise. We support this with a new, unified, model of their evolutionary ecology, using contemporary evolutionary theory coupling the Price equation with game theory, studying the consequences of the molecular replicators' promiscuous use of each others' gene products for their natural history and evolutionary ecology...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27848950/the-rectal-mucosa-and-condomless-receptive-anal-intercourse-in-hiv-negative-msm-implications-for-hiv-transmission-and-prevention
#20
C F Kelley, C S Kraft, T Jb de Man, C Duphare, H-W Lee, J Yang, K A Easley, G K Tharp, M J Mulligan, P S Sullivan, S E Bosinger, R R Amara
Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal mucosa. However, it is unclear how the act of condomless receptive anal intercourse (CRAI) may alter the mucosal immune environment in HIV-negative MSM. Here, we performed a comprehensive characterization of the rectal mucosal immune environment for the phenotype and production of pro-inflammatory cytokines by CD4 and CD8 T cells, global transcriptomic analyses, and the composition of microbiota in HIV-negative MSM...
November 16, 2016: Mucosal Immunology
keyword
keyword
40912
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"