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Xiaoyun Liu, Ningling Sun, Tao Yu, Fangfang Fan, Meili Zheng, Geng Qian, Binyan Wang, Yu Wang, Genfu Tang, Jianping Li, Xianhui Qin, Fanfan Hou, Xiping Xu, Xinchun Yang, Yundai Chen, Xiaobin Wang, Yong Huo
This study aimed to investigate the independent and joint association of blood pressure (BP), homocysteine (Hcy), and fasting blood glucose (FBG) levels with brachial-ankle pulse wave velocity (baPWV, a measure of arterial stiffness) in Chinese hypertensive adults.The analyses included 3967 participants whose BP, Hcy, FBG, and baPWV were measured along with other covariates. Systolic BP (SBP) was analyzed as 3 categories (SBP < 160 mmHg; 160 to 179 mmHg; ≥ 180 mmHg); Hcy as 3 categories (< 10 μmol/L; 10 to 14...
September 28, 2016: International Heart Journal
Li Zuo, Mia Wang, Fanfan Hou, Yucheng Yan, Nan Chen, Jiaqi Qian, Mei Wang, Brian Bieber, Ronald L Pisoni, Bruce M Robinson, Shuchi Anand
BACKGROUND: As the utilization of hemodialysis increases in China, it is critical to examine anemia management. METHODS: Using data from the China Dialysis Outcomes and Practice Patterns Study (DOPPS), we describe hemoglobin (Hgb) distribution and anemia-related therapies. RESULTS: Twenty one percent of China's DOPPS patients had Hgb <9 g/dl, compared with ≤10% in Japan and North America. A majority of medical directors targeted Hgb ≥11...
2016: Blood Purification
Changlin Mei, Nan Chen, Xiaoqiang Ding, Xueqing Yu, Li Wang, Jiaqi Qian, Mei Wang, Gengru Jiang, Xuemei Li, Fanfan Hou, Li Zuo, Niansong Wang, Hong Liu
Introduction Secondary hyperparathyroidism (SHPT) develops in patients with chronic renal failure. Cinacalcet hydrochloride has been used successfully in U.S., Europe, and Japan in the treatment of SHPT, while maintaining serum levels of calcium and phosphorus. The efficacy and safety profile of Cinacalcet treatment vs. conventional treatments has been of great interest in clinical practice. In this recent phase III study conducted in China, efficacy and safety of a calcimimetic agent, Cinacalcet (Kyowa Hakko Kirin Co...
March 4, 2016: Hemodialysis International
Di Xie, Yan Yuan, Jiangnan Guo, Shenglin Yang, Xin Xu, Qin Wang, Youbao Li, Xianhui Qin, Genfu Tang, Yong Huo, Guangpu Deng, Shengjie Wu, Binyan Wang, Qin Zhang, Xiaobin Wang, Pu Fang, Hong Wang, Xiping Xu, Fanfan Hou
Hyper-homocysteinemia (HHcy) is associated with microalbuminuria and glomerular injury in general and diabetic populations. However, HHcy's role in hypertensive patients was not studied. We investigated whether HHcy is an independent risk factor for renal function decline and development of chronic kidney disease (CKD) in hypertensive men and women. This was a community-based prospective cohort study of 2,387 hypertensive adults without CKD at baseline, with a mean follow-up of 4.4 years. Baseline and follow-up levels of plasma Hcy, folate, vitamin B12, blood pressure and other pertinent covariables were obtained...
2015: Scientific Reports
Yue Cui, Bing Liu, Yuan Zhou, Lingzhong Fan, Jin Li, Yun Zhang, Huawang Wu, Bing Hou, Chao Wang, Fanfan Zheng, Chengxiang Qiu, Li-Lin Rao, Yuping Ning, Shu Li, Tianzi Jiang
Various brain structural and functional features such as cytoarchitecture, topographic mapping, gyral/sulcal anatomy, and anatomical and functional connectivity have been used in human brain parcellation. However, the fine-grained intrinsic genetic architecture of the cortex remains unknown. In the present study, we parcellated specific regions of the cortex into subregions based on genetic correlations (i.e., shared genetic influences) between the surface area of each pair of cortical locations within the seed region...
September 2016: Cerebral Cortex
Haibo Li, Xianhui Qin, Di Xie, Genfu Tang, Yan Zhang, Jianping Li, Fanfan Hou, Xiaobin Wang, Yong Huo, Xiping Xu
Objective The efficacy of combined treatment consisting of enalapril and folic acid (FA) was compared to that of enalapril alone in reducing the serum uric acid (UA) levels in adult hypertensive patients in China. Methods Patients with mild to moderate hypertension (n=480) were randomly assigned to one of three treatment groups: (1) 10 mg enalapril (control group), (2) 10 mg enalapril plus 0.4 mg FA (low-FA group) or (3) 10 mg enalapril plus 0.8 mg FA (high-FA group) daily for eight weeks. The primary outcome was the UA ratio (week 8 UA: baseline UA)...
2015: Internal Medicine
Xianhui Qin, Yuejuan Wang, Youbao Li, Di Xie, Genfu Tang, Binyan Wang, Xiaobin Wang, Xin Xu, Xiping Xu, Fanfan Hou
BACKGROUND: We aimed to examine the risk factors for renal function decline (RFD) in a community-based cohort of a rural Chinese population with normal kidney function (estimated glomerular filtration rate, eGFR ≥60 mL/min/1.73 m(2)), both for the population as a whole and stratified by sex. METHODS: 2518 participants were included in the current analysis. RFD was defined as follows: a drop in the eGFR category accompanied by a 25% or greater drop in eGFR from baseline; or a sustained decline in eGFR of more than 5 mL/min/1...
August 2015: Journal of Epidemiology and Community Health
Xianhui Qin, Youbao Li, Hui Yuan, Di Xie, Genfu Tang, Binyan Wang, Xiaobin Wang, Xin Xu, Xiping Xu, Fanfan Hou
East Asian patients with diabetes have a higher risk for renal complications and strokes than Europeans. We aimed to evaluate the effect of methylenetetrahydrofolate reductase (MTHFR) gene 677 C → T polymorphism, which was associated with a higher stroke risk and was common in the Chinese population, as well as homocysteine and estimated glomerular filtration rate (eGFR) levels on the risk of new-onset diabetes (NOD). A total of 2422 subjects without diabetes were followed-up for 7 years. NOD was defined as fasting plasma glucose ≥ 7...
February 2015: Medicine (Baltimore)
Shengcun Guo, Shuxin Shen, Junfen Wang, He Wang, Meiyu Li, Ying Liu, Fanfan Hou, Yulin Liao, Jianping Bin
OBJECTIVE: Ultrasound molecular imaging (UMI) of glycoprotein (GP) IIb/IIIa receptor on activated platelets offers a unique means of identifying high-risk atherosclerosis. We hypothesized that contrast-enhanced ultrasound with microbubbles (MBs) targeted to GP IIb/IIIa could be used to detect and quantify activated platelets on the surface of advanced plaques. METHODS AND RESULTS: A mouse model of advanced atherosclerosis was generated by maintaining apolipoprotein E-deficient (ApoE(-/-)) mice on a hypercholesterolemic diet (HCD)...
2015: Theranostics
Yuelong Ji, Xiangyi Kong, Guoying Wang, Xiumei Hong, Xin Xu, Zhu Chen, Tami Bartell, Xiping Xu, Genfu Tang, Fanfan Hou, Yong Huo, Xiaobin Wang, Binyan Wang
Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10-66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender...
December 2014: Nutrients
Qin Wang, Di Xie, Xin Xu, Xianhui Qin, Genfu Tang, Binyan Wang, Yu Wang, Fanfan Hou, Xiping Xu, Xiaobin Wang
BACKGROUND: The most recent guidelines for the management of hypertension (Eighth Joint National Committee) indicate the need of more evidence for hypertensive persons aged below 60 years. We sought to examine the relationship between baseline blood pressure (BP) and renal function decline in a 7-year prospective cohort study of 2383 rural Chinese men and women aged 40-60 years. METHODS: Multiple linear and logistic regressions were applied to estimate sex-specific associations between baseline BP level and annual estimated glomerular filtration rate (eGFR) change estimated by the Chronic Kidney Disease Epidemiology Collaboration method and rapid eGFR decline (>3 ml/min per 1...
January 2015: Journal of Hypertension
Youbao Li, Di Xie, Xianhui Qin, Genfu Tang, Houxun Xing, Zhiping Li, Xiping Xu, Xin Xu, Fanfan Hou
BACKGROUND & AIMS: The purpose of this study was to evaluate the effect of metabolic syndrome (Mets) and insulin resistance (IR) on the risk of renal function decline (RFD) in a rural Chinese cohort. METHODS: A total of 2696 subjects aged 40-71 years with normal renal function were followed-up for 7 years. RFD was defined using the Kidney Disease: Improving Global Outcome definition, i.e., a drop in estimated glomerular filtration rate (eGFR) category accompanied by a 25% or greater drop in eGFR from baseline or a sustained decline in eGFR of more than 5 mL/min/1...
April 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Nan Chen, Xiongfei Wu, Xiaoqiang Ding, Changlin Mei, Ping Fu, Gengru Jiang, Xuemei Li, Jianghua Chen, Bicheng Liu, Yan La, Fanfan Hou, Zhaohui Ni, Junzhou Fu, Changying Xing, Xuequing Yu, Chaoxing Huang, Li Zuo, Li Wang, John Hunter, Maureen Dillon, Melissa Plone, John Neylan
BACKGROUND: Hyperphosphataemia in patients with advanced chronic kidney disease (CKD) is associated with adverse outcomes, including vascular calcification and higher mortality rates. While phosphate lowering is an integral aspect of CKD management, the efficacy and safety of phosphate binders in a contemporary cohort of Chinese haemodialysis patients (who have different genetics and dietary patterns than other populations) has not been previously described. Moreover, sparse data are available on strategies for optimal dose titration when transitioning from a calcium-based to a polymer-based phosphate binder...
January 2014: Nephrology, Dialysis, Transplantation
Weilan Wu, Yan Wang, Shuxin Shen, Juefei Wu, Shengcun Guo, Liang Su, Fanfan Hou, Zhigang Wang, Yulin Liao, Jianping Bin
OBJECTIVE: Ultrasound molecular imaging has the potential to detect activated platelets, thus identifying atherosclerotic plaque instability before onset of serious clinical events. However, it has not been well defined in inflammatory arterial thrombosis. We hypothesized that microbubbles (MBs) target glycoprotein IIb/IIIa (GP IIb/IIIa) could achieve a noninvasive in vivo detection of inflammatory thrombosis in large arteries through contrast-enhanced ultrasound (CEU) imaging. MATERIALS AND METHODS: Lipid shell-based gas-filled MBs were modified covalently with a cyclic Arg-Gly-Asp (RGD) peptide (MB-cRGD) targeted to activated GP IIb/IIIa or a negative control peptide (MB-CON) via thiol-maleimide coupling...
November 2013: Investigative Radiology
Xianhui Qin, Yong Huo, Di Xie, Fanfan Hou, Xiping Xu, Xiaobin Wang
BACKGROUND & AIMS: The efficacy of homocysteine-lowering therapy with folic acid to lower homocysteine levels in an effort to reduce cardiovascular disease (CVD) risk in patients with kidney disease remains inconclusive. We conducted a meta-analysis of relevant randomized trials to further examine this issue. METHODS: This meta-analysis included 8234 patients with kidney disease from nine qualified randomized trials using folic acid therapy, and with CVD reported as one of the endpoints...
October 2013: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Xianglei Kong, Luxia Zhang, Ling Zhang, Nan Chen, Yong Gu, Xueqing Yu, Wenhu Liu, Jianghua Chen, Liren Peng, Weijie Yuan, Hua Wu, Wei Chen, Minhua Fan, Liqun He, Feng Ding, Xiangmei Chen, Zuying Xiong, Jinyuan Zhang, Qiang Jia, Wei Shi, Changying Xing, Xiaoling Tang, Fanfan Hou, Guiyang Shu, Changlin Mei, Li Wang, Dongmei Xu, Zhaohui Ni, Li Zuo, Mei Wang, Haiyan Wang
BACKGROUND: Mineral and bone disorder (MBD) in patients with chronic kidney disease is associated with increased morbidity and mortality. Studies regarding the status of MBD treatment in developing countries, especially in Chinese dialysis patients are extremely limited. METHODS: A cross-sectional study of 1711 haemodialysis (HD) patients and 363 peritoneal dialysis (PD) patients were enrolled. Parameters related to MBD, including serum phosphorus (P), calcium (Ca), intact parathyroid hormone (iPTH) were analyzed...
2012: BMC Nephrology
Fanfan Hou, Jianping Jiang, Jianghua Chen, Xueqing Yu, Qiugen Zhou, Pingyan Chen, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Di Xie, Jun Liu, Ping Zhang, Xiao Yang, Yixiang Zhang, Yanmin Zhang, Xinling Liang, Zhimin Zhang, Qizhan Lin, Yan Yu, Shengjie Wu, Xin Xu
BACKGROUND: Cardiovascular disease (CVD) is the main cause of death in patients on chronic dialysis. The question whether dialysis modality impacts cardiovascular risk remains to be addressed. China Collaborative Study on Dialysis, a multi-centers cohort study, was performed to evaluate cardiovascular morbidity during maintenance hemodialysis (HD) and peritoneal dialysis (PD). METHOD: The cohort consisted of chronic dialysis patients from the database of 9 of the largest dialysis facilities around China...
2012: BMC Nephrology
Qing Dong, Genfu Tang, Mingli He, Yunqing Cai, Yefeng Cai, Houxun Xing, Liming Sun, Jianping Li, Yan Zhang, Fangfang Fan, Binyan Wang, Ningling Sun, Lisheng Liu, Xiping Xu, Fanfan Hou, Hongbing Shen, Xin Xu, Yong Huo
BACKGROUND: Plasma level of total homocysteine (tHcy) is negatively correlated with kidney function in general population. However, the causal mechanism of this correlation is poorly understood. The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese. METHODS: A total of 18 814 hypertensive patients (6,914 males, 11,900 females) were included in the study...
August 16, 2012: BMC Medical Genetics
Jianping Jiang, Pingyan Chen, Jianghua Chen, Xueqing Yu, Di Xie, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Ping Zhang, Xiao Yang, Yixiang Zhang, Yanmin Zhang, Xinling Liang, Zhimin Zhang, Qizhan Lin, Yan Yu, Toshio Miyata, Jianwei Tian, Min Liang, Weihong Luo, Xin Xu, Fanfan Hou
OBJECTIVES: Accumulation of tissue advanced glycation end products (AGEs) is a marker of cumulative glycemic and/or oxidative stress. Cutaneous AGEs levels measured by skin autofluorescence correlate well with cardiovascular outcomes in diabetes and hemodialysis (HD) patients. The present study aimed to compare tissue AGEs levels with peritoneal dialysis (PD) and HD patients and to evaluate the relationship between skin autofluorescence and cardiovascular morbidity in patients on PD. METHODS: A total of 2388 maintenance dialysis patients (613 PD and 1775 HD) were enrolled in this cross-sectional study...
September 2012: Atherosclerosis
Qiugen Zhou, Chunmei Zhao, Di Xie, Dingli Xu, Jianping Bin, Pingyan Chen, Min Liang, Xun Zhang, Fanfan Hou
BACKGROUND: Acute worsening of renal function, an independent risk factor for adverse outcomes in acute decompensated heart failure (ADHF), occurs as a consequence of new onset kidney injury (AKI) or acute deterioration of pre-existed chronic kidney disease (CKD) (acute-on-chronic kidney injury, ACKI). However, the possible difference in prognostic implication between AKI and ACKI has not been well established. METHODS: We studied all consecutive patients hospitalized with ADHF from 2003 through 2010 in Nanfang Hospital...
2012: BMC Nephrology
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