keyword
MENU ▼
Read by QxMD icon Read
search

Melatonin

keyword
https://www.readbyqxmd.com/read/27921018/comparison-of-the-protective-effects-of-erythropoietin-and-melatonin-on-renal-ischemia-reperfusion-injury
#1
Shokofeh Banaei, Nasser Ahmadiasl, Alireza Alihemmati
BACKGROUND: Renal ischemia-reperfusion (IR) contributes to the development of acute renal failure (ARF). Oxygen free radicals are considered to be the principal components involved in the pathophysiological tissue alterations observed during renal IR. OBJECTIVES: In this study, we compared the effects of melatonin (MEL) and erythropoietin (EPO), both known antioxidant and anti-inflammatory agents, on IR-induced renal injury in rats. MATERIALS AND METHODS: Wistar albino rats were unilaterally nephrectomized and then subjected to 45 minutes of renal pedicle occlusion followed by 24 hours of reperfusion...
July 2016: Trauma Monthly
https://www.readbyqxmd.com/read/27919824/melatonin-s-role-as-a-co-adjuvant-treatment-in-colonic-diseases-a-review
#2
REVIEW
Eduardo Esteban-Zubero, Laura López-Pingarrón, Moisés Alejandro Alatorre-Jiménez, Purificación Ochoa-Moneo, Celia Buisac-Ramón, Miguel Rivas-Jiménez, Silvia Castán-Ruiz, Ángel Antoñanzas-Lombarte, Dun-Xian Tan, José Joaquín García, Russel J Reiter
Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense system by increasing the activities of antioxidant enzymes, and to stimulate the innate immune response through its direct and indirect actions. In addition, the dysregulation of the circadian system is observed to be related with alterations in colonic motility and cell disruptions due to the modifications of clock genes expression...
December 2, 2016: Life Sciences
https://www.readbyqxmd.com/read/27915492/preparation-and-in-vitro-evaluation-of-melatonin-loaded-ha-pva-gelformulations
#3
Sakine Tuncay Tanrıverdi, Catalina Natalia Cheaburu-Yilmaz, Sonia Carbone, Özgen Özer
Melatonin loaded hyaluronic acid and poly(vinyl alcohol) gels were prepared by using freeze-thaw technique and an emulsion method followed by freeze-thaw technique to produce a new synergistic system for topical application. Freeze-thaw hydrogels and emulgels were characterized by means of Fourier Transform Infrared Spectroscopy, rheology and swelling tests. The porous structure of the hydrogels was shown by scanning electron microscopy observations and thermal properties were tested by Differential Scanning Calorimetry measurements...
December 5, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27914990/presence-of-melanopsin-in-human-crystalline-lens-epithelial-cells-and-its-role-in-melatonin-synthesis
#4
Hanan Awad Alkozi, Xiaoyu Wang, Maria Jesus Perez de Lara, Jesus Pintor
Melanopsin is a non-image forming photoreceptor known to be present in the retina and it is considered to have light regulated tasks among other functions. In the present work, melanopsin presence in human lens epithelial cells as well as in human lens tissue is described for the first time. Moreover, studying the concentration of melatonin and its synthesising enzyme AANAT proved a clear link between melanopsin activation and the suppression of melatonin synthesis. Melanopsin sensitivity to specific wavelength (465-480 nm, blue) was confirmed after making temporal studies incubating lens epithelial cells under light, red, green, blue and total darkness for 2, 4, 8, 12 h and analysing the concentration of both melatonin and its synthesising enzyme AANAT, discovering that melatonin levels after submitting cells to total darkness are significantly higher to ones submitted to white or specifically blue light (***p < 0...
November 30, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27912116/application-of-melatonin-loaded-poly-n-isopropylacrylamide-hydrogel-particles-to-reduce-the-toxicity-of-airborne-pollutes-to-raw264-7-cells
#5
Wenjing Zhang, Pengfei Jiang, Jin Chen, Chaonan Zhu, Zhengwei Mao, Changyou Gao
The adverse effect of airborne PM2.5 pollutes on human beings and the environment, most likely due to heavy metal leaching, has received extensive attention recently. It is urgently required to develop a simple and effective method to suppress the toxicity of PM2.5 pollutes. In this study, the heavy metal content of PM2.5 pollutes around Zhejiang university were firstly identified. Their cytotoxicity was confirmed, by inducing significantly enhanced intracellular reactive oxygen species level. Poly(N-isopropylacrylamide) (PNIPAM) submicron hydrogel particles with tunable crosslinking densities and thermo-responsive swelling/shrinking properties were then prepared by adjusting the crosslinking density...
November 22, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27911044/utilization-of-stimulants-and-atomoxetine-for-attention-deficit-hyperactivity-disorder-among-5-4-million-children-using-population-based-longitudinal-data
#6
Kari Furu, Øystein Karlstad, Helga Zoega, Jaana E Martikainen, Shahram Bahmanyar, Helle Kieler, Anton Pottegård
Use of stimulants to treat Attention-deficit/hyperactivity disorder (ADHD) has increased over the past two decades and varies substantially between countries. The objective of this multinational population-based study was to examine utilization of ADHD drugs (stimulants and atomoxetine) including co-medication with other psychothropic drugs in the entire child population in the five Nordic countries. We included longitudinal data on dispensed ADHD drugs from five Nordic prescription registers during 2008-2012; which in 2012 comprised 48,296 individuals among 5...
December 2, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27910708/myo-inositol-and-melatonin-in-the-menopausal-transition
#7
Rosario D'Anna, Angelo Santamaria, Grazia Giorgianni, Alberto Vaiarelli, Giuseppe Gullo, Flavia Di Bari, Salvatore Benvenga
INTRODUCTION: The aim of the study was to evaluate the effects on serum insulin and serum thyroid profile of a dietary supplement, myo-inositol, given alone or in combination with melatonin to women during menopausal transition. METHODS: Forty women aged 45-55 years and at least 6 months of amenorrhea were enrolled in this study. They were randomly assigned to two groups of 20 each. One group took myo-inositol (myo-Ins) (2 g twice a day) and the other group took 2 g/d myo-Ins plus 3 g/d melatonin before sleeping...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27909960/effects-of-melatonin-aluminum-oxide-and-polymethylsiloxane-complex-on-the-expression-of-lyve-1-in-the-liver-of-mice-with-obesity-and-type-2-diabetes-mellitus
#8
S V Michurina, I Yu Ishchenko, S A Arkhipov, V V Klimontov, L N Rachkovskaya, V I Konenkov, E L Zavyalov
The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels...
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27909592/effect-of-day-and-night-desflurane-anaesthesia-on-melatonin-levels-in-rats
#9
Figen Datlı Özer, Elvan Öçmen, Pınar Akan, Hale Aksu Erdost, Sezen Korkut, Ali Necati Gökmen
OBJECTIVE: The aim of this study is to investigate the effect of day and night administration of desflurane anaesthesia on melatonin levels in rats. METHODS: Twenty-four 15-day-old rats were included in the study and were divided into four groups. The rats were anaesthetised between 19:00-01:00 (night group) and 07:00-13:00 (day group) with 5.7% desflurane concentration in 6 L min(-1) 100% oxygen. 6 L min(-1) oxygen was administered to the control groups. At the end of 6 h of anaesthesia, blood samples were taken, and rats were sacrificed...
August 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27904735/urinary-metabolomics-of-young-italian-autistic-children-supports-abnormal-tryptophan-and-purine-metabolism
#10
Federica Gevi, Lello Zolla, Stefano Gabriele, Antonio M Persico
BACKGROUND: Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in providing earlier and more reliable diagnoses. Metabolomics on human biofluids provides a sensitive tool to identify metabolite profiles potentially usable as biomarkers for ASD. Initial metabolomic studies, analyzing urines and plasma of ASD and control individuals, suggested that autistic patients may share some metabolic abnormalities, despite several inconsistencies stemming from differences in technology, ethnicity, age range, and definition of "control" status...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27904671/melatonin-promotes-diabetic-wound-healing-in-vitro-by-regulating-keratinocyte-activity
#11
Ruipeng Song, Lijun Ren, Haoli Ma, Ruijing Hu, Honghong Gao, Li Wang, Xuehui Chen, Zhigang Zhao, Jialin Liu
Diabetic patients are at high risk of developing delayed cutaneous wound healing. Proper keratinocyte proliferation and migration are crucial steps during re-epithelialization. Melatonin (Mel) accelerates wound repair in full-thickness incisional wounds; however, its role in diabetic wound healing is unknown. This study explored the role of Mel in diabetic wound healing in vitro by using high glucose (HG)-cultured keratinocytes. Mel reduced the HG-induced mRNA expression and release of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-8, in keratinocytes...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27900599/melatonin-attenuates-manganese-and-lipopolysaccharide-induced-inflammatory-activation-of-bv2-microglia
#12
Euteum Park, Hong Sung Chun
Melatonin, a naturally occurring neurohormone in the pineal gland, has been shown to exert antioxidant and anti-inflammatory effects. This study examined the effects of melatonin on manganese (Mn) and/or lipopolysaccharide (LPS)-induced microglial activation. Melatonin (10 μM) inhibited Mn (100 μM) and/or LPS (0.5 μg/ml)-induced phagocytotic activity of activated BV2 microglia. It also inhibited the lipid peroxidation and intracellular reduced glutathione (GSH) depletion induced by Mn and/or LPS. Melatonin effectively suppressed the upregulation of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) at both mRNA and protein levels in Mn and/or LPS-stimulated BV2 microglia...
November 30, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27899931/melatonin-in-plants-and-plant-culture-systems-variability-stability-and-efficient-quantification
#13
Lauren A E Erland, Abhishek Chattopadhyay, Andrew Maxwell P Jones, Praveen K Saxena
Despite growing evidence of the importance of melatonin and serotonin in the plant life, there is still much debate over the stability of melatonin, with extraction and analysis methods varying greatly from lab to lab with respect to time, temperature, light levels, extraction solvents, and mechanical disruption. The variability in methodology has created conflicting results that confound the comparison of studies to determine the role of melatonin in plant physiology. We here describe a fully validated method for the quantification of melatonin, serotonin and their biosynthetic precursors: tryptophan, tryptamine and N-acetylserotonin by liquid chromatography single quadrupole mass spectrometry (LC-MS) in diverse plant species and tissues...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27899698/illuminating-a-risk-for-breast-cancer-a-preliminary-ecological-study-on-the-association-between-streetlight-and-breast-cancer
#14
Atalya Keshet-Sitton, Keren Or-Chen, Eran Huber, Abraham Haim
Artificial light at night (ALAN) for elongating photophase is a new source of pollution. We examined the association between measured ALAN levels and breast cancer (BC) standard morbidity ratio (SMR) at a statistical area (SA) level in an urban environment. Sample size consisted of 266 new BC cases ages 35-74. Light measurements (lux) were performed in 11 SAs. A new calculated variable of morbidity per SA size (SMR35-74/km(2)) was correlated with the light variables per road length, using Pearson correlations (P < ...
November 29, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27899301/role-for-nf-%C3%AE%C2%BAb-inflammatory-signalling-pathway-in-tenofovir-disoproxil-fumarate-tdf-induced-renal-damage-in-rats
#15
Hemalatha Ramamoorthy, Premila Abraham, Bina Isaac, Dhayakani Selvakumar
Nephrotoxicity due to tenofovir treatment of HIV patients has been reported. However, the mechanism of tenofovir nephrotoxicity is not clear. NFκB is an important proinflammatory transcription factor that plays a pivotal role in oxidative stress-induced inflammation. We hypothesized that NFκB proinflammatory signalling pathway may play a role in tenofovir induced renal damage. Renal damage was induced in adult male Wistar rats by the oral administration of 600 mg/kg body wt. daily for 5 consecutive weeks...
November 27, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27899171/the-effects-of-melatonin-and-colchicine-on-ischemia-reperfusion-injury-in-experimental-rat-testicular-torsion-model
#16
Tamer Sekmenli, Metin Gunduz, Bahadır Öztürk, Pınar Karabağlı, Ilhan Ciftci, Gülsüm Tekin, Mustafa Yılmaz
PURPOSE: The aim of the present study is to investigate the efficiency of colchicine and melatonın in an experimental rat testicular torsion model in the light of histological and biochemical data. METHODS: A total of 34 Wistar albino male rats were randomly divided into 5 groups as: Group C (control, n=6), Group S (sham; underwent only left scrotal exploration, n=7), Group TD (torsion and detorsion; 6h of ischemia and 7days of reperfusion, n=7), Group TD/M (TD+Melatonin; 6h of ischemia and 7days of reperfusion and 7days of 17mg/kg intraperitoneal melatonin per day, n=7), group TD/Col (TD+Colchicine; 6h of ischemia and 7days of reperfusion and 7days of 1mg/kg oral colchicine per day, n=7)...
November 18, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27897121/role-of-melatonin-in-body-weight-a-systematic-review-and-meta-analysis
#17
Seyed-Ali Mostafavi, Shahin Akhondzadeh, Mohammad Reza Mohammadi, Abbas-Ali Keshtkar, Saeed Hosseini, Mohammad Reza Eshraghian, Fahimeh Ahmadi, Roya Alipour, Seyed Ali Keshavarz
BACKGROUND: Some trials on animals and human claim that melatonin can influence body weight. So we conducted a systematic review of controlled trials of melatonin effects on weight of human subjects. METHODS: First we performed a systematic and comprehensive search in June 2015 on MEDLINE/PubMed, Scopus, Google scholar, hand searching in key journals, the list of references of selected articles and gray literature. RESULTS: We included 7 clinical trials with a total of 244 patients...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27894252/transcriptome-analysis-reveals-the-genetic-basis-underlying-the-seasonal-development-of-keratinized-nuptial-spines-in-leptobrachium-boringii
#18
Wei Zhang, Yue Guo, Jun Li, Li Huang, Eric Gilbert Kazitsa, Hua Wu
BACKGROUND: The expression of sexually selected traits often varies with populations' breeding cycles in many animals. The elucidation of mechanisms underlying the expression of such traits is a research topic in evolutionary biology; however, the genetic basis of the seasonal development of their expression remains unknown. Male Leptobrachium boringii develop keratinized nuptial spines on their upper jaw during the breeding season that fall off when the breeding season ends. To illuminate the genetic basis for the expression of this trait and its seasonal development, we assessed the de novo transcriptome for L...
November 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27891070/monoaminergic-mechanisms-in-epilepsy-may-offer-innovative-therapeutic-opportunity-for-monoaminergic-multi-target-drugs
#19
REVIEW
Dubravka Svob Strac, Nela Pivac, Ilse J Smolders, Wieslawa A Fogel, Philippe De Deurwaerdere, Giuseppe Di Giovanni
A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual monoamines nor their interaction has yet been fully clarified due to the complexity of these neurotransmitter systems. In addition, epilepsy is diverse, with many different seizure types and epilepsy syndromes, and the role played by monoamines may vary from one condition to another...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27890022/continuous-light-after-2-months-of-long-days-stimulates-ram-testis-volume-and-increases-fertility-in-spring
#20
D Chesneau, D Guillaume, P Chemineau, B Malpaux
Seasonal reproduction is one of the major biotechnical and economic constraints of sheep production in temperate latitudes. Treatments using extra light followed by melatonin implants have been used satisfactorily in open barns, farms and artificial insemination centres to produce out-of-season sexual activity in rams. The aim of the present study is to explore the possibility of replacing melatonin implants with continuous light (LL), which was recently shown to increase LH secretion similar to melatonin and/or pinealectomy...
November 28, 2016: Animal: An International Journal of Animal Bioscience
keyword
keyword
4091
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"