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https://www.readbyqxmd.com/read/29907977/melatonin-induces-mechanisms-of-brain-resilience-against-neurodegeneration
#1
Rubén Corpas, Christian Griñán-Ferré, Verónica Palomera-Ávalos, David Porquet, Pablo García de Frutos, Silvia M Franciscato Cozzolino, Eduard Rodríguez-Farré, Mercè Pallàs, Coral Sanfeliu, Bárbara R Cardoso
Melatonin is an endogenous pleiotropic molecule which orchestrates regulatory functions and protective capacity against age-related ailments. The increase in circulating levels of melatonin through dietary supplements intensifies its health benefits. Investigations in animal models have shown that melatonin protects against Alzheimer's disease (AD)-like pathology, although clinical studies have not been conclusive. We hypothesized that melatonin induces changes in the brain that prevent or attenuate AD by increasing resilience...
June 15, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29907916/the-effects-of-melatonin-supplementation-on-inflammatory-markers-among-patients-with-metabolic-syndrome-or-related-disorders-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Maryam Akbari, Vahidreza Ostadmohammadi, Reza Tabrizi, Kamran B Lankarani, Seyed Taghi Heydari, Elaheh Amirani, Russel J Reiter, Zatollah Asemi
OBJECTIVE: This systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to determine the effect of melatonin supplementation on the inflammatory markers among individuals with metabolic syndrome (MetS) and related disorders. METHODS: We searched the following databases up to March 2018: PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. Three reviewers independently assessed study eligibility, extracted data, and evaluated risk of bias of included primary studies...
June 15, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29907085/long-term-persistence-of-withdrawal-of-temazepam-zopiclone-and-zolpidem-in-older-adults-a-3-year-follow-up-study
#3
Juha Puustinen, Ritva Lähteenmäki, Janne Nurminen, Tero Vahlberg, Pertti Aarnio, Markku Partinen, Ismo Räihä, Pertti J Neuvonen, Sirkka-Liisa Kivelä
BACKGROUND: Studies on persistence of benzodiazepine agonist (BZDA) withdrawal in older outpatients are few, and few studies on long-term persistence over years have yet been published. To describe the persistence of temazepam, zolpidem, and zopiclone (BZDA) withdrawal among older outpatients at 3 years from the beginning of withdrawal, as well as any changes in use of other medications. METHODS: 92 outpatients (≥55 years) with primary insomnia, long-term BZDA use as hypnotics (mean duration of BZDA use 9...
June 15, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29906492/the-influence-of-ageing-on-the-extrapineal-melatonin-synthetic-pathway
#4
Branka Popović, Milica Velimirović, Tihomir Stojković, Gavrilo Brajović, Silvio R De Luka, Ivan Milovanović, Srdjan Stefanović, Dragica Nikolić, Jasna L Ristić-Djurović, Nataša D Petronijević, Alexander M Trbovich
Ageing affects various physiological and metabolic processes in a body and a progressive accumulation of oxidative damage stands out as often used explanation. One of the most powerful scavenger of reactive oxygen species (ROS) in all organs is melatonin. A majority of melatonin supplied to the body via blood originates from the pineal gland. However, we have been interested in a locally produced melatonin. We have used 2.5- and 36-months-old Wistar rats. Tissues were collected and gene expression of AA-NAT and ASMT, the two key enzymes in a synthesis of melatonin, was determined in brain, liver, kidney, heart, skin, and intestine...
June 12, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29904403/relationship-of-melatonin-level-oxidative-stress-and-inflammatory-status-with-osteoporosis-in-maintenance-hemodialysis-of-chronic-renal-failure
#5
Haiwei Ren, Renlian Sun, Jian Wang
The relationship of melatonin (MT) level, oxidative stress and inflammatory status with osteoporosis in the maintenance hemodialysis (MHD) of chronic renal failure was investigated. Ninety-four patients with chronic renal failure treated in Dezhou People's Hospital (Dezhoo, China) and receiving MHD for more than 3 months from May to April 2017 were selected and divided into the osteoporosis group (observation group, n=49) and the non-osteoporosis group (control group, n=45) based on whether osteoporosis was involved...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904335/neuroprotection-targeting-protein-misfolding-on-chronic-cerebral-hypoperfusion-in-the-context-of-metabolic-syndrome
#6
REVIEW
María I Herrera, Lucas D Udovin, Nicolás Toro-Urrego, Carlos F Kusnier, Juan P Luaces, Matilde Otero-Losada, Francisco Capani
Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH to Alzheimer's disease. Protein misfolding results in neurodegeneration as revealed by studying different experimental models of CCH. Regulating proteostasis network through pathways like the unfolded protein response (UPR), the ubiquitin-proteasome system (UPS), chaperone-mediated autophagy (CMA), and macroautophagy emerges as a novel target for neuroprotection...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29902071/anti-inflammatory-effects-of-melatonin-a-mechanistic-review
#7
Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Antoni Sureda, Janbo Xiao, Ahmad Reza Dehpour, Samira Shirooie, Ana Sanches Silva, Alessandra Baldi, Haroon Khan, Maria Daglia
N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In humans, melatonin participates in numerous functions including the regulation of mood, sleep, reproduction, promotion of immunomodulation, antioxidant defense and as an anti-inflammatory agent. The anti-inflammatory activity of melatonin could yield beneficial effects on intake, particularly against the chronic inflammation which underlies many chronic diseases...
June 14, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29901843/premature-leaf-senescence-3-encoding-a-methyltransferase-is-required-for-melatonin-biosynthesis-in-rice
#8
Yongbo Hong, Yingxin Zhang, Sittipun Sinumporn, Ning Yu, Xiaodeng Zhan, Xihong Shen, Daibo Chen, Ping Yu, Weixun Wu, Qunen Liu, Zhaoyun Cao, Chunde Zhao, Shihua Cheng, Liyong Cao
Premature leaf senescence in rice is one of the most common factors affecting the plant's development and yield. Although methyltransferases are involved in diverse biological functions, their roles in rice leaf senescence have not been previously reported. In this study, we identified the premature leaf senescence 3 (pls3) mutant in rice, which led to early leaf senescence and early heading date. Further investigations revealed that premature leaf senescence was triggered by the accumulation of reactive oxygen species (ROS)...
June 14, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29901413/melatonin-as-a-treatment-after-traumatic-brain-injury-a-systematic-review-and-meta-analysis-of-the-pre-clinical-and-clinical-literature
#9
Karen Barlow, Michael M J Esser, Myra Veidt, Roslyn Boyd
Traumatic brain injury is common and yet effective treatments of the secondary brain injury are scarce. Melatonin is a potent, non-selective neuroprotective and anti-inflammatory agent that is showing promising results in neonatal brain injury. The aim of this study was to systematically evaluate the pre-clinical and clinical literature for the effectiveness of Melatonin to improve outcome after TBI. Using the systematic review protocol for animal intervention studies (SYRCLE) and Cochrane methodology for clinical studies, a search of English articles was performed...
June 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29900537/melatonin-expression-in-periodontitis-and-obesity-an-experimental-in-vivo-investigation
#10
L Virto, H J Haugen, P Fernández-Mateos, P Cano, J González, V Jiménez-Ortega, A I Esquifino, M Sanz
BACKGROUND AND OBJECTIVE: Melatonin deficiency has been associated with obesity and systemic inflammation. This study aims to evaluate whether melatonin could interfere with the mechanisms of co-morbidity linking obesity and periodontitis. MATERIAL AND METHODS: Twenty-eight male Wistar rats were randomly divided in 4 groups: control group (Con) (fed with standard diet); high-fat diet group (HFD) (fed with a diet containing 35.2% fat); Con group with induced periodontitis (Con-Perio) and HFD group with induced periodontitis (HFD-Perio)...
June 14, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29898779/melatonin-rescued-interleukin-1%C3%AE-impaired-chondrogenesis-of-human-mesenchymal-stem-cells
#11
Bo Gao, Wenjie Gao, Zizhao Wu, Taifeng Zhou, Xianjian Qiu, Xudong Wang, Chengjie Lian, Yan Peng, Anjing Liang, Jincheng Qiu, Yuanxin Zhu, Caixia Xu, Yibing Li, Peiqiang Su, Dongsheng Huang
BACKGROUND: Osteoarthritis (OA) is a widespread arthritic disease and a primary cause of disability. Increasing evidence suggests that inflammation has a pivotal part in its pathogenesis. Interleukin-1β (IL-1β) is a primary mediator of local inflammatory processes in OA. Current therapies for OA mainly focus on the symptoms of the advanced stage of the disease. The possible utilization of bone marrow mesenchymal stem cells (BMSCs) to regenerate cartilage is an appealing method, but in the case of OA requires chondrogenesis to take place within an inflamed environment...
June 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29898451/pathophysiology-of-depression-molecular-regulation-of-melatonin-homeostasis-current-status
#12
REVIEW
Monika Dmitrzak-Weglarz, Edyta Reszka
Circadian rhythm alterations resulting in disturbed sleep and disturbed melatonin secretion are flagship features of depression. Melatonin, known as a hormone of darkness, is secreted by the pineal gland located near to the center of the brain between the two hemispheres. Melatonin has an antidepressant effect by maintaining the body's circadian rhythm, by regulating the pattern of expression of the clock genes in the suprachiasmatic nucleus (SCN) and modifying the key genes of serotoninergic neurotransmission that are linked with a depressive mood...
June 13, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29897926/genome-wide-identification-and-expression-profile-analysis-of-the-nac-transcription-factor-family-during-abiotic-and-biotic-stress-in-woodland-strawberry
#13
He Zhang, Hao Kang, Chulian Su, Yanxiang Qi, Xiaomei Liu, Jinji Pu
The NAC transcription factors involved plant development and response to various stress stimuli. However, little information is available concerning the NAC family in the woodland strawberry. Herein, 37 NAC genes were identified from the woodland strawberry genome and were classified into 13 groups based on phylogenetic analysis. And further analyses of gene structure and conserved motifs showed closer relationship of them in every subgroup. Quantitative real-time PCR evaluation different tissues revealed distinct spatial expression profiles of the FvNAC genes...
2018: PloS One
https://www.readbyqxmd.com/read/29896808/effect-of-monochromatic-light-on-circadian-rhythm-of-clock-genes-in-chick-pinealocytes
#14
Shuhui Ma, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
The avian circadian system is a complex of mutually coupled pacemakers residing in pineal gland, retina and suprachiasmatic nucleus. In this study, the self-regulation mechanism of pineal circadian rhythm was investigated by culturing chick primary pinealocytes exposed to red light (RL), green light (GL), blue light (BL), white light (WL) and constant darkness (DD), respectively. All illuminations were set up with a photoperiod of 12 light: 12 dark. The 24-h expression profiles of seven core clock genes (cBmal1/2, cClock, cCry1/2, and cPer2/3), cAanat and melatonin showed significant circadian oscillation in all groups, except for the loss of cCry1 rhythm in BL...
June 13, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29896269/beneficial-effects-of-dexmedetomidine-on-early-postoperative-cognitive-dysfunction-in-pediatric-patients-with-tonsillectomy
#15
Chuanlai Han, Rong Fu, Weifu Lei
According to clinical investigations, early postoperative cognitive dysfunction is the most common adverse event in pediatric patients after tonsillectomy. A previous study has indicated that dexmedetomidine (DEX) is an efficient drug for the treatment of postoperative cognitive dysfunction. However, the efficacy of DEX in alleviating early postoperative cognitive dysfunction in pediatric patients following tonsillectomy has remained elusive, which was therefore assessed in the present study. A total of 186 children presenting with cognitive dysfunction subsequent to tonsillectomy were recruited to analyze the efficacy of DEX...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895782/effects-of-melatonin-and-its-underlying-mechanism-on-ethanol-stimulated-senescence-and-osteoclastic-differentiation-in-human-periodontal-ligament-cells-and-cementoblasts
#16
Won-Jung Bae, Jae Suh Park, Soo-Kyung Kang, Il-Keun Kwon, Eun-Cheol Kim
The present study evaluated the protective effects of melatonin in ethanol (EtOH)-induced senescence and osteoclastic differentiation in human periodontal ligament cells (HPDLCs) and cementoblasts and the underlying mechanism. EtOH increased senescence activity, levels of reactive oxygen species (ROS) and the expression of cell cycle regulators (p53, p21 and p16) and senescence-associated secretory phenotype ( SASP ) genes (interleukin [IL]-1β, IL-6, IL-8 and tumor necrosis factor-α) in HPDLCs and cementoblasts...
June 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29895193/melatonin-promotes-cashmere-goat-capra-hircus-secondary-hair-follicle-growth-a-view-from-integrated-analysis-of-long-non-coding-and-coding-rnas
#17
Wei Ge, Shan-He Wang, Bing Sun, Yue-Lang Zhang, Wei Shen, Hasan Khatib, Xin Wang
The role of melatonin in promoting the yield of Cashmere goat wool has been demonstrated for decades though there remains a lack of knowledge regarding melatonin mediated hair follicle growth. Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are widely transcribed in the genome and play ubiquitous roles in regulating biological processes. However, the role of lncRNAs in regulating melatonin mediated hair follicle growth remains unclear. In this study, we established an in vitro Cashmere goat secondary hair follicle culture system, and demonstrated that 500 ng/L melatonin exposure promoted hair follicle fiber growth...
June 12, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29894760/circadian-rhythms-of-melatonin-and-behaviour-in-juvenile-sheep-in-field-conditions-effects-of-photoperiod-environment-and-weaning
#18
C A Wyse, X Zhang, M McLaughlin, S M Biello, D Hough, M Bellingham, A M Curtis, J E Robinson, N P Evans
Entrainment of circadian rhythms (CR) to the light dark cycle has been well described under controlled, experimental conditions. However, studies in rodents have reported that rhythms in the laboratory are not always reproduced under field conditions. The aim of this study was to characterise the CR of sheep maintained under conditions of standard UK farm animal husbandry and to investigate the effects of environmental challenges presented by season, weaning and changes in housing on CR. Male sheep (n = 9) were kept at pasture, or group housed in barns, under natural photoperiod for one year...
June 9, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29892224/melatonin-attenuates-dysregulation-of-the-circadian-clock-pathway-in-mice-with-ccl-4-induced-fibrosis-and-human-hepatic-stellate-cells
#19
Bárbara González-Fernández, Diana I Sánchez, Irene Crespo, Beatriz San-Miguel, Juan Ortiz de Urbina, Javier González-Gallego, María J Tuñón
Dysregulation of the circadian clock machinery is a critical mechanism in the pathogenesis of fibrosis. This study aimed to investigate whether the antifibrotic effect of melatonin is associated with attenuation of circadian clock pathway disturbances in mice treated with carbon tetrachloride (CCl4 ) and in human hepatic stellate cells line LX2. Mice received CCl4 5 μL/g body weight i.p. twice a week for 4 or 6 weeks. Melatonin was given at 5 or 10 mg/kg/day i.p., beginning 2 weeks after the start of CCl4 administration...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29891016/melatonin-ameliorates-h-2-o-2-induced-oxidative-stress-through-modulation-of-erk-akt-nfkb-pathway
#20
Mahammed Moniruzzaman, Indranath Ghosal, Debjit Das, Suman Bhusan Chakraborty
BACKGROUND: Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative damage in different vertebrates. Aim of the current communication is to evaluate the levels of oxidative stress and ROS induced damage, and amelioration of oxidative status through melatonin induced activation of signaling pathways. Hepatocytes were isolated from adult Labeo rohita and exposed to H2 O2 at three different doses (12...
June 11, 2018: Biological Research
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