keyword
MENU ▼
Read by QxMD icon Read
search

Melatonin

keyword
https://www.readbyqxmd.com/read/29665070/a-time-to-be-born-variation-in-the-hour-of-birth-in-a-rural-population-of-northern-argentina
#1
Carlye Chaney, Laura G Goetz, Claudia Valeggia
OBJECTIVES: The present study aimed at investigating the timing of birth across the day in a rural population of indigenous and nonindigenous women in the province of Formosa, Argentina in order to explore the variation in patterns in a non-Western setting. MATERIALS AND METHODS: This study utilized birth record data transcribed from delivery room records at a rural hospital in the province of Formosa, northern Argentina. The sample included data for Criollo, Wichí, and Toba/Qom women (n = 2421)...
April 17, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29665051/hyperbaric-oxygen-treatment-sensitizes-gastric-cancer-cells-to-melatonin-induced-apoptosis-through-multiple-pathways
#2
Xiang Wei, Yinliang Qi, Ning Jia, Qing Zhou, Sumei Zhang, Yuan Wang
Although extensive efforts have been made in recent decades to treat advanced gastric cancer with comprehensive therapy based on chemotherapy, effective anti-gastric cancer therapeutics are still lacking in the clinics. Therefore, potent novel anti-gastric cancer ways are greatly needed. Here, we explored hyperbaric oxygen treatment as a novel and effective adjuvant treatment method which has anti-gastric cancer effects when used together with melatonin. When performed together with MLT, HBO effectively inhibited tumorigenicity of gastric cancer through selectively inducing a robust tumor suppressive apoptosis response...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663591/research-progress-on-the-role-of-melatonin-and-its-receptors-in-animal-reproduction-a-comprehensive-review
#3
REVIEW
H S Talpur, I B Chandio, R D Brohi, T Worku, Z Rehman, D Bhattarai, F Ullah, L JiaJia, L Yang
Melatonin and its receptors play a crucial role in the regulation of the animal reproductive process, primarily in follicular development. However, the role that melatonin performs in regulating hormones related with reproduction remains unclear. Melatonin and its receptors are present both in female and male animals' organs, such as ovaries, heart, brain and liver. Melatonin regulates ovarian actions and is a key mediator of reproductive actions. Melatonin has numerous effects on animal reproduction, such as protection of gametes and embryos, response to clock genes, immune-neuroendocrine, reconciliation of seasonal variations in immune function, and silence or blockage of genes...
April 16, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29660304/circadian-rhythm-resynchronization-improved-isoflurane-induced-cognitive-dysfunction-in-aged-mice
#4
Jia Song, Shuaishuai Chu, Yin Cui, Yue Qian, Xiuxiu Li, Fangxia Xu, Xueming Shao, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Postoperative cognitive dysfunction (POCD) is a common clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery. Advanced age is a significant independent risk factor for POCD. We previously reported that in young mice, sleep-wake rhythm is involved in the isoflurane-induced memory impairment. In present study, we sought to determine whether advanced age increased the risk of POCD through aggravated and prolonged post-anesthetic circadian disruption in the elderly. We constructed POCD model by submitting the mice to 5-h 1...
April 13, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29659490/a-comparative-genomic-survey-provides-novel-insights-into-molecular-evolution-of-l-aromatic-amino-acid-decarboxylase-in-vertebrates
#5
Yanping Li, Yunyun Lv, Chao Bian, Xinxin You, Li Deng, Qiong Shi
Melatonin is a pleiotropic molecule with various important physiological roles in vertebrates. l-aromatic amino acid decarboxylase (AAAD) is the second enzyme for melatonin synthesis. By far, a clear-cut gene function of AAAD in the biosynthesis of melatonin has been unclear in vertebrates. Here, we provide novel insights into the evolution of AAAD based on 77 vertebrate genomes. According to our genome-wide alignments, we extracted a total of 151 aaad nucleotide sequences. A phylogenetic tree was constructed on the basis of these sequences and corresponding protein alignments, indicating that tetrapods and diploid bony fish genomes contained one aaad gene and a new aaad -like gene, which formed a novel AAAD family...
April 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29658305/liver-antioxidant-and-aerobic-status-improves-after-metformin-and-melatonin-administration-in-a-rat-model-of-high-fat-diet-and-mammary-carcinogenesis
#6
Natalia Kurhaluk, Bianka Bojková, Pawel J Winklewski
Oxidative stress is involved in the development of various cancers. In the present study the effect of long-term administration of peroral antidiabetic metformin and pineal hormone melatonin on liver antioxidant and aerobic status in female Sprague-Dawley rats carrying mammary tumors induced by N-methyl-N-nitrosourea was evaluated. Both substances were administered in a preventive/curative manner (12 days before and 16 weeks after the carcinogen application). Carcinogen administration induced oxidative stress: the level of thiobarbituric acid reactive products (TBARS) as a marker of reactive oxygen species (ROS) generation in liver increased as well as the level of oxidatively modified protein content (OMP, aldehyde and ketone derivates)...
April 15, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29657392/effect-of-exogenous-melatonin-and-different-photoperiods-on-oxidative-status-and-antioxidant-enzyme-activity-in-chhotanagpuri-ewe
#7
Pankaj Kumar Choudhary, Ajay Kumar Ishwar, Rajesh Kumar, Debasish Niyogi, Mukesh Kumar
Aim: The present study was conducted to evaluate the effect of exogenous melatonin under different photoperiods on oxidative status in Chhotanagpuri ewe. Materials and Methods: A total of 42 non-pregnant, non-lactating Chhotanagpuri ewe, having body weight ranging between 14.11±0.09 and 15.38±0.06 kg, were selected and were isolated from rams 2 months before melatonin administration. The selected animals were allocated randomly into seven groups, namely, Group I (normal control), Group II (long day [LD] control), Group III (LD+melatonin administration orally, 3 mg/day), Group IV (LD+melatonin administration subcutaneously, 1 mg/day), Group V (short day [SD] control), Group VI (SD+melatonin administration orally, 3 mg/day), and Group VII (SD+melatonin administration subcutaneously, 1 mg/day) comprising six animals in each group...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29656983/prophylaxis-and-treatment-of-foetal-growth-restriction
#8
REVIEW
Aamod Nawathe, Anna L David
Foetal growth restriction (FGR) and associated placental pathologies such as pre-eclampsia and stillbirth arise in early pregnancy when inadequate remodelling of maternal spiral arteries leads to persistent high-resistance low-flow uteroplacental circulation. Current interventions concentrate on targeting the placental ischaemia-reperfusion injury and oxidative stress associated with an imbalance in angiogenic/anti-angiogenic factors. Recent meta-analyses confirm that aspirin modestly reduces the risk for small-for-gestational-age pregnancy in high-risk women...
February 23, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29656698/association-between-a-melatonin-receptor-1b-genetic-polymorphism-and-its-protein-expression-in-gestational-diabetes-mellitus
#9
Chao Li, Yubin Zhou, Binglong Qiao, Lin Xu, Yan Li, Can Li
AIMS: This study was conducted to investigate the relationship between a genetic polymorphism and the expression of melatonin receptor 1B (MTNR1B) in the placenta of Han Chinese women with gestational diabetes mellitus (GDM). METHODS: In this study, 215 patients with GDM and 243 healthy controls were genotyped using direct sequencing for the MTNR1B single-nucleotide polymorphism rs10830963. The expression of MTNR1B in placenta was detected by immunohistochemistry and Western blotting...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29656328/human-colostrum-action-against-giardia-lamblia-infection-influenced-by-hormones-and-advanced-maternal-age
#10
Queli Lisiane Castro Pereira, Cristiane de Castro Pernet Hara, Rubian Trindade Silva Fernandes, Danny Laura Gomes Fagundes, Aline do Carmo França-Botelho, Maria Aparecida Gomes, Eduardo Luzía França, Adenilda Cristina Honorio-França
Children are more susceptible to Giardia lamblia infection. Cells and hormones contained in human colostrum have an immunoprotective action against giardiasis, but the effects of advanced maternal age on these components are poorly understood. This study analyzed the colostrum of older women to determine melatonin and cortisol levels besides the participation of these hormones on the functional activity of phagocytes against G. lamblia. Colostrum samples were collected from younger (18 to 35 years old) and older (over 36 years old) lactating women...
April 14, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29656092/sleep-deprivation-impairs-cognitive-performance-in-zebrafish-a-matter-of-fact
#11
Jaquelinne Pinheiro-da-Silva, Steven Tran, Ana Carolina Luchiari
The zebrafish (Danio rerio) has become a valuable model organism for behavioral studies examining learning and memory. Its diurnal circadian rhythm and characterized sleep-like state make it comparable to mammals, features that have contributed to establishing this small vertebrate as a translational model for sleep research. Despite sleep being an evolutionarily conserved behavior, its mechanisms and functions are still debated. Sleep deprivation is commonly associated with decreased attention, reduced responsiveness to external stimuli, altered locomotor activity and impaired performance on cognitive tasks...
April 12, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29653386/synergistic-effects-of-resveratrol-and-melatonin-on-in-vitro-maturation-of-porcine-oocytes-and-subsequent-embryo-development
#12
Sanghoon Lee, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A Kim, Byeong Chun Lee
Resveratrol and melatonin are known for their antioxidant properties and have various biological activities. The fact that they exhibit possible synergistic effects in phytomedicine researches suggests the use of a combination of these agents to promote porcine in vitro maturation (IVM) of oocytes. Therefore, we investigated the effects of resveratrol and/or melatonin on this process; cumulus-oocyte complexes underwent IVM culture with four different conditions (control, resveratrol, melatonin or their combination)...
April 5, 2018: Theriogenology
https://www.readbyqxmd.com/read/29653194/chronic-agomelatine-treatment-prevents-comorbid-depression-in-the-post-status-epilepticus-model-of-acquired-epilepsy-through-suppression-of-inflammatory-signaling
#13
Jana Tchekalarova, Dimitrinka Atanasova, Lidia Kortenska, Milena Atanasova, Nikolai Lazarov
Inflammatory signal molecules are suggested to be involved in the mechanism underlying comorbid depression in epilepsy. In the present study, we tested the hypothesis that the novel antidepressant agomelatine, a potent melatonin MT1 and MT2 receptor agonist and serotonin 5HT2C receptor antagonist, can prevent depressive symptoms developed during the chronic epileptic phase by suppressing an inflammatory response. Chronic treatment with agomelatine (40 mg/kg, i.p.) was initiated an hour after the kainate acid (KA)-induced status epilepticus (SE) and maintained for a period of 10 weeks in Wistar rats...
April 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29649764/sleep-after-intranasal-progesterone-vs-zolpidem-and-placebo-in-postmenopausal-women-a-randomized-double-blind-cross-over-study
#14
P Schüssler, M Kluge, M Adamczyk, M E Beitinger, P Beitinger, A Bleifuss, S Cordeiro, C Mattern, M Uhr, T C Wetter, A Yassouridis, R Rupprecht, E Friess, A Steiger
CONTEXT: The loss of progesterone during menopause is linked to sleep complaints of the affected women. Previously we demonstrated sleep promoting effects of oral progesterone replacement in postmenopausal women. The oral administration of progesterone, however, is compromised by individual differences in bioavailability and metabolism of the steroid. OBJECTIVE: We compared the sleep-endocrine effects after intranasal progesterone (MPP22), zolpidem and placebo in healthy postmenopausal women...
April 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29642678/polymorphisms-of-melatonin-receptor-genes-and-their-associations-with-egg-production-traits-in-shaoxing-duck
#15
Peishi Feng, Wanqiu Zhao, Qiang Xie, Tao Zeng, Lizhi Lu, Lin Yang
Objective: In birds, three types of melatonin receptors (MTNR1A, MTNR1B and MTNR1C) have been cloned. Previous researches have showed that three melatonin receptors played an essential role in reproduction and ovarian physiology. However, the association of polymorphisms of the three receptors with duck reproduction traits and egg quality traits is still unknown. In this test, we chose MTNR1A, MTNR1B and MTNR1C as candidate genes to detect novel sequence polymorphism and analyze their association with egg production traits in Shaoxing duck, and detected their mRNA expression level in ovaries...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29642520/melatonin-protects-against-lung-fibrosis-by-regulating-the-hippo-yap-pathway
#16
Xiaoguang Zhao, Jian Sun, Wei Su, Huitong Shan, Bowen Zhang, Yining Wang, Azaliia Shabanova, Hongli Shan, Haihai Liang
Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial pneumonia with high mortality. Melatonin, a hormone predominantly secreted by the pineal gland, has been reported to participate in the process of IPF. However, the mechanisms underlying the effect of melatonin in pulmonary fibrosis have not been elucidated to date. This study was designed to evaluate the anti-fibrotic role of melatonin in pulmonary fibrosis and to elucidate the potential mechanisms. We observed that melatonin markedly attenuated bleomycin (BLM)-induced experimental lung fibrosis in mice and inhibited TGF-β1-induced fibrogenesis in lung fibroblasts...
April 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29628120/immunomorphometric-variations-of-sustentacular-cells-of-the-male-viscacha-adrenal-medulla-during-the-annual-reproductive-cycle-effects-of-androgens-and-melatonin
#17
Luis Ezequiel Gallol, Fabian Heber Mohamed
The adrenal medulla is crucial for the survival of species facing significant environmental changes. The parenchyma is composed mainly of chromaffin cells, ganglion cells and sustentacular cells (SC). The male viscacha exhibits seasonal variations of gonadal activity and other metabolic functions. The aim of this work was to investigate the influence of the reproductive conditions on the morphology of SC of this rodent. In addition, the effects of testosterone and melatonin on these cells were studied. Immunoexpression of S100 protein, GFAP and vimentin were analyzed...
April 5, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29626529/pre-vs-post-treatment-with-melatonin-in-ccl-4-induced-liver-damage-oxidative-stress-inferred-from-biochemical-and-pathohistological-studies
#18
Vanja P Ničković, Tatjana Novaković, Slavica Lazarević, Ljiljana Šulović, Zorica Živković, Jovan Živković, Bojan Mladenović, Nikola M Stojanović, Vladmir Petrović, Dušan T Sokolović
AIMS: The present study was designed to compare the ameliorating potential of pre- and post-treatments with melatonin, a potent natural antioxidant, in the carbon tetrachloride-induced rat liver damage model by tracking changes in enzymatic and non-enzymatic liver tissue defense parameters, as well as in the occurring pathohistological changes. MAIN METHODS: Rats from two experimental groups were treated with melatonin before and after CCl4 administration, while the controls, negative and positive, received vehicle/melatonin and CCl4 , respectively...
April 4, 2018: Life Sciences
https://www.readbyqxmd.com/read/29625838/suppression-of-melatonin-secretion-in-totally-visually-blind-people-by-ocular-exposure-to-white-light-clinical-characteristics
#19
Joseph T Hull, Charles A Czeisler, Steven W Lockley
PURPOSE: Although most totally visually blind individuals exhibit nonentrained circadian rhythms due to an inability of light to entrain the circadian pacemaker, a small proportion retain photic circadian entrainment, melatonin suppression, and other nonimage-forming responses to light. It is thought that these responses to light persist because of the survival of melanospin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), which project primarily to the circadian pacemaker and are functionally distinct from the rod and cone photoreceptors that mediate vision...
April 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29625122/periodic-regulation-of-expression-of-genes-for-kisspeptin-gonadotropin-inhibitory-hormone-and-their-receptors-in-the-grass-puffer-implications-in-seasonal-daily-and-lunar-rhythms-of-reproduction
#20
REVIEW
Hironori Ando, Shahjahan, Takashi Kitahashi
The seasonal, daily and lunar control of reproduction involves photoperiodic, circadian and lunar changes in the activity of kisspeptin, gonadotropin-inhibitory hormone (GnIH) and gonadotropin-releasing hormone (GnRH) neurons. These changes are brought through complex networks of light-, time- and non-photic signal-dependent control mechanisms, which are mostly unknown at present. The grass puffer, Takifugu alboplumbeus, a semilunar spawner, provides a unique and excellent animal model to assess this question because its spawning is synchronized with seasonal, daily and lunar cycles...
April 3, 2018: General and Comparative Endocrinology
keyword
keyword
4091
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"