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Neoadjuvant chemotherapy bladder cancer

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https://www.readbyqxmd.com/read/29043112/tumor-infiltrating-cd8-lymphocytes-predict-different-clinical-outcomes-in-organ-and-non-organ-confined-urothelial-carcinoma-of-the-bladder-following-radical-cystectomy
#1
Shiqiang Zhang, Jun Wang, Xinyu Zhang, Fangjian Zhou
Tumor-infiltrating lymphocytes (TILs) are associated with better clinical outcomes in many tumors. TILs represent a cell-mediated immune response against the carcinoma. CD8+ TILs are a crucial component of cell-mediated immunity. The significance of CD8+ TILs has not been reported respectively in organ- and non-organ-confined urothelial carcinoma (UC) of the bladder. We explored the prognostic value of CD8+ TILs in the two groups. The presence of CD8+ TILs was assessed by immunohistochemical staining of whole tissue sections from 75 organ and 51 non-organ-confined disease patients with long-term follow-up, and its correlation with clinicopathological features and overall survival (OS) was determined...
2017: PeerJ
https://www.readbyqxmd.com/read/29032239/outcomes-following-clinical-complete-response-to-neoadjuvant-chemotherapy-for-muscle-invasive-urothelial-carcinoma-of-the-bladder-in-patients-refusing-radical-cystectomy
#2
Dennis Robins, Justin Matulay, Michael Lipsky, Alexa Meyer, Rashed Ghandour, Guarionex DeCastro, Christopher Anderson, Charles Drake, Mitchell Benson, James McKiernan
OBJECTIVE: To investigate survival outcomes of patients with muscle-invasive bladder cancer (MIBC) that demonstrate complete clinical response (cT0) to neoadjuvant chemotherapy (NAC) and then reject subsequent radical cystectomy (RC). MATERIALS AND METHODS: A retrospective chart review identified MIBC patients who were cT0 after platinum-based NAC. CT0 was defined as negative cytology, cystoscopy with transurethral resection of bladder tumor (TURBT), and imaging...
October 12, 2017: Urology
https://www.readbyqxmd.com/read/29030318/the-association-between-mortality-and-distance-to-treatment-facility-in-patients-with-muscle-invasive-bladder-cancer
#3
Stephen Ryan, Emily C Serrell, Patrick Karabon, Gregory Mills, Moritz Hansen, Matthew Hayn, Mani Menon, Quoc-Dien Trinh, Firas Abdollah, Jesse D Sammon
PURPOSE: Regionalization of bladder cancer treatment is suggested to improve quality of care. As an unintended consequence, some patients travel farther for care with unknown implications on outcomes. We characterize the relationship between distance and overall mortality in patients with invasive bladder cancer and those who undergo radical cystectomy. METHODS: We performed a retrospective cohort study using the National Cancer Database (2004-2012) to identify patients with muscle invasive bladder cancer (cT2a-T4 N0 M0); a sub-group of radical cystectomy patients was extracted...
October 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28982751/clinical-significance-of-histologic-variants-of-bladder-cancer
#4
REVIEW
Joshua I Warrick
Pathologists have identified many "histologic variants" of bladder cancer (BCA): histologic patterns that differ from conventional urothelial carcinoma (transitional cell carcinoma). Several of these are biologically aggressive, and their identification may aid in clinical decision-making. This article reviews several histologic variants and their value in deciding management of cT1 disease and predicting response to neoadjuvant chemotherapy (NAC). Diagnostic issues are also addressed, such as interobserver variability among pathologists...
October 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28982487/management-of-muscle-invasive-urothelial-cancer-and-the-emerging-role-of-immunotherapy-in-advanced-urothelial-cancer
#5
REVIEW
Karthik V Giridhar, Manish Kohli
The incidence of bladder cancer has increased in the past decade, and mortality from bladder cancer remains a substantial public health burden. After 3 decades of minimal progress in the treatment of advanced-stage disease, recent advances in the genomic characterization of urothelial cancer and breakthroughs in bladder cancer therapeutics have rejuvenated the field. This review highlights the landmark clinical trials of chemotherapy in both the neoadjuvant and advanced or metastatic urothelial carcinoma settings...
October 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28978923/immunological-tumor-status-may-predict-response-to-neoadjuvant-chemotherapy-and-outcome-after-radical-cystectomy-in-bladder-cancer
#6
Minna Tervahartiala, Pekka Taimen, Tuomas Mirtti, Ilmari Koskinen, Thorsten Ecke, Sirpa Jalkanen, Peter J Boström
Bladder cancer (BC) is the ninth most common cancer worldwide. Radical cystectomy (RC) with neoadjuvant chemotherapy (NAC) is recommended for muscle-invasive BC. The challenge of the neoadjuvant approach relates to challenges in selection of patients to chemotherapy that are likely to respond to the treatment. To date, there are no validated molecular markers or baseline clinical characteristics to identify these patients. Different inflammatory markers, including tumor associated macrophages with their plastic pro-tumorigenic and anti-tumorigenic functions, have extensively been under interests as potential prognostic and predictive biomarkers in different cancer types...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28967556/re-low-pretreatment-neutrophil-to-lymphocyte-ratio-predicts-for-good-outcomes-in-patients-receiving-neoadjuvant-chemotherapy-before-radical-cystectomy-for-muscle-invasive-bladder-cancer
#7
https://www.readbyqxmd.com/read/28951117/impact-of-packed-red-blood-cells-and-fresh-frozen-plasma-given-during-radical-cystectomy-and-urinary-diversion-on-cancer-related-outcome-and-survival-an-observational-cohort-study
#8
Marc A Furrer, Adrian Fellmann, Marc P Schneider, George N Thalmann, Fiona C Burkhard, Patrick Y Wuethrich
BACKGROUND: The relationship between blood transfusion and cancer-related outcome and mortality is controversial. OBJECTIVE: To assess if perioperative administration of packed red blood cell (PRBC) and fresh frozen plasma (FFP) units affects disease progression and survival after radical cystectomy for bladder cancer. DESIGN, SETTING, AND PARTICIPANTS: We conducted an observational single-centre cohort study of a consecutive series of 885 bladder cancer patients, between 2000 and 2015...
September 23, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28905486/peri-operative-allogeneic-blood-transfusion-does-not-adversely-affect-oncological-outcomes-after-radical-cystectomy-for-urinary-bladder-cancer-a-propensity-score-weighted-european-multicentre-study
#9
Malte W Vetterlein, Philipp Gild, Luis A Kluth, Thomas Seisen, Michael Gierth, Hans-Martin Fritsche, Maximilian Burger, Chris Protzel, Oliver W Hakenberg, Nicolas von Landenberg, Florian Roghmann, Joachim Noldus, Philipp Nuhn, Armin Pycha, Michael Rink, Felix K-H Chun, Matthias May, Margit Fisch, Atiqullah Aziz
OBJECTIVES: To evaluate the effect of peri-operative blood transfusion (PBT) on recurrence-free survival, overall survival, cancer-specific mortality and other-cause mortality in patients undergoing radical cystectomy (RC), using a contemporary European multicentre cohort. PATIENTS AND METHODS: The Prospective Multicentre Radical Cystectomy Series (PROMETRICS) includes data on 679 patients who underwent RC at 18 European tertiary care centres in 2011. The association between PBT and oncological survival outcomes was assessed using Kaplan-Meier, Cox regression and competing-risks analyses...
September 14, 2017: BJU International
https://www.readbyqxmd.com/read/28878595/neoadjuvant-platinum-based-chemotherapy-is-an-independent-predictor-for-preoperative-thromboembolic-events-in-bladder-cancer-patients-undergoing-radical-cystectomy
#10
Cliodhna Browne, Niall F Davis, William J Nolan, Eoin D MacCraith, Gerald M Lennon, David W Mulvin, David J Galvin, David M Quinlan
INTRODUCTION: Neoadjuvant chemotherapy (NAC) confers a significant survival benefit in patients with muscle invasive bladder cancer. Platinum-based chemotherapy increases the risk of thromboembolic events (TEE). We determined the effect of cisplatin-based NAC on the incidence of preoperative TEEs in radical cystectomy patients. MATERIALS AND METHODS: A retrospective matched case-control study was performed on 55 patients undergoing radical cystectomy for muscle invasive bladder cancer...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28866245/incidence-and-effect-of-thromboembolic-events-in-radical-cystectomy-patients-undergoing-preoperative-chemotherapy-for-muscle-invasive-bladder-cancer
#11
Aditya Bagrodia, Ranjit Sukhu, Andrew G Winer, Eric Levy, Michael Vacchio, Byron Lee, Eugene J Pietzak, Timothy F Donahue, Eugene Cha, Gopa Iyer, Daniel D Sjoberg, Andrew J Vickers, Jonathan E Rosenberg, Dean F Bajorin, Guido Dalbagni, Bernard H Bochner
BACKGROUND: We evaluated the incidence and effect of thromboembolic events (TEEs) in patients with muscle-invasive bladder cancer treated with preoperative chemotherapy (POC) and radical cystectomy (RC) with pelvic lymph node dissection (PLND). PATIENTS AND METHODS: We performed a retrospective review of all patients who had undergone POC followed by RC plus PLND for muscle-invasive bladder cancer from June 2000 to January 2013 (n = 357). The chemotherapy type (neoadjuvant vs...
August 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28864844/checkpoint-inhibitors-the-new-treatment-paradigm-for-urothelial-bladder-cancer
#12
REVIEW
Heather Katz, Emnet Wassie, Mohamed Alsharedi
Bladder cancer is the most common malignancy involving the genitourinary system (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). In the USA, it is the fifth most common cancer and approximately 79,000 new cases will be diagnosed in 2017 (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). The mortality from bladder cancer is approximately 17,000 deaths each year (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). The incidence rate for bladder cancer is higher in men compared to women. Risk factors are predominantly related to tobacco smoking, although infection with Schistosoma haematobium is another risk factor in selected populations (Antoni et al...
September 1, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28842247/treatment-patterns-and-overall-survival-outcomes-of-octogenarians-with-muscle-invasive-cancer-of-the-bladder-an-analysis-of-the-national-cancer-database
#13
Benjamin W Fischer-Valuck, Yuan James Rao, Soumon Rudra, Daniel Przybysz, Elizabeth Germino, Pamela Samson, Brian C Baumann, Hiram Gay, Jeff Michalski
PURPOSE: Elderly patients with muscle invasive bladder cancer can pose a therapeutic dilemma given multiple comorbidities which may preclude surgery. This registry-based analysis investigated treatment patterns and survival outcomes in this group of patients. MATERIALS AND METHODS: We queried the National Cancer Database for muscle-invasive (cT2-T4aN0M0) bladder cancer in patients 80 years or older diagnosed from 2004-2013. Included patients underwent TURBT followed by radical cystectomy (RC), RC plus chemotherapy (RC+C), radiation therapy alone (RT), chemotherapy alone (CT), chemoradiation (CRT), or no treatment...
August 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28837718/adjuvant-chemotherapy-vs-observation-for-patients-with-adverse-pathologic-features-at-radical-cystectomy-previously-treated-with-neoadjuvant-chemotherapy
#14
Thomas Seisen, Asha Jamzadeh, Jeffrey J Leow, Morgan Rouprêt, Alexander P Cole, Stuart R Lipsitz, Adam S Kibel, Paul L Nguyen, Maxine Sun, Mani Menon, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
Importance: Despite existing evidence of a benefit associated with cisplatin-based adjuvant chemotherapy (AC) after radical cystectomy (RC) for chemotherapy-naive patients with pT3/T4 and/or pN+ urothelial carcinoma of the bladder (UCB), to our knowledge, no studies have addressed the effectiveness of AC in those who received neoadjuvant chemotherapy (NAC) before surgery. Objective: To assess the comparative effectiveness of AC vs observation for patients with pT3/T4 and/or pN+ UCB previously treated with NAC and RC...
August 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28818551/adverse-pathology-after-neoadjuvant-chemotherapy-and-radical-cystectomy-the-role-of-adjuvant-chemotherapy
#15
William P Parker, Elizabeth B Habermann, Courtney N Day, Harras B Zaid, Igor Frank, R Houston Thompson, Matthew K Tollefson, Stephen A Boorjian, Lance C Pagliaro, R Jeffrey Karnes
BACKGROUND: The current guidelines do not recommend adjuvant chemotherapy (AC) for patients with adverse pathologic findings after neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) for bladder cancer. We sought to evaluate the association of AC with overall survival (OS) in these patients. MATERIALS AND METHODS: The National Cancer Database was used to identify patients with adverse pathologic findings (ypT3N0, ypT4N0, or ypTanyN1-N3) after NAC and RC for bladder cancer from 2006 to 2012...
July 22, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28815808/intravoxel-incoherent-motion-diffusion-weighted-imaging-in-assessing-bladder-cancer-invasiveness-and-cell-proliferation
#16
Fang Wang, Lian-Ming Wu, Xiao-Lan Hua, Zi-Zhou Zhao, Xiao-Xi Chen, Jian-Rong Xu
BACKGROUND: Nonmuscle-invasive bladder cancer (NMIBC, Stage T1 or lower) is treated with transurethral resection (TUR), while muscle-invasive bladder cancer (MIBC, Stage T2 or more) requires neoadjuvant chemotherapy before radical cystectomy. Hence, preoperative differentiation is vital. PURPOSE: To investigate whether intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) can differentiate NMIBC from MIBC and to assess whether there were correlations between IVIM parameters and the Ki-67 labeling index (LI)...
August 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28803791/squamous-differentiation-predicts-poor-response-to-cisplatin-based-chemotherapy-and-unfavorable-prognosis-in-urothelial-carcinoma-of-the-urinary-bladder
#17
Akinori Minato, Naohiro Fujimoto, Tatsuhiko Kubo
OBJECTIVE: The efficacy of chemotherapy on UCSD is not known. This study was conducted to investigate the efficacy of cisplatin-based chemotherapy and prognosis of patients with UC with or without SD of the bladder. METHODS: Patients with invasive bladder cancer (clinical T3-4aN0M0) who were treated between March 2003 and March 2015 with 2 or 3 cycles of neoadjuvant chemotherapy followed by radical cystectomy were retrospectively evaluated. Treatment outcomes were compared for each pathologic type in UCSD and pure UC...
July 22, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28753879/robot-assisted-versus-open-radical-cystectomy-in-patients-receiving-perioperative-chemotherapy-for-muscle-invasive-bladder-cancer-the-oncologist-s-perspective-from-a-multicentre-study
#18
Andrea Necchi, Gregory R Pond, Marc C Smaldone, Sumanta K Pal, Kevin Chan, Yu-Ning Wong, Rosalia Viterbo, Guru Sonpavde, Lauren C Harshman, Simon Crabb, Ajjai Alva, Simon Chowdhury, Ugo De Giorgi, Sandy Srinivas, Neeraj Agarwal, Aristotelis Bamias, Jack Baniel, Ali-Reza Golshayan, Sylvain Ladoire, Cora N Sternberg, Linda Cerbone, Evan Y Yu, Joaquim Bellmunt, Ulka Vaishampayan, Gunter Niegisch, Syed Hussain, Daniel W Bowles, Rafael Morales-Barrera, Matthew I Milowsky, Christine Theodore, Dominik R Berthold, Srikala S Sridhar, Thomas Powles, Jonathan E Rosenberg, Matthew D Galsky
BACKGROUND: Little is known about the outcomes of robot-assisted radical cystectomy (RARC) compared to open radical cystectomy (ORC) combined with perioperative chemotherapy for muscle-invasive urothelial bladder cancer (UBC). OBJECTIVE: To evaluate surgical and oncological outcomes for RARC and ORC in multimodal treatment. DESIGN, SETTING, AND PARTICIPANTS: Data from 28 centres were collected for cystectomies performed between January 2000 and July 2013...
March 31, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753857/the-impact-of-plasmacytoid-variant-histology-on-the-survival-of-patients-with-urothelial-carcinoma-of-bladder-after-radical-cystectomy
#19
Qiang Li, Melissa Assel, Nicole E Benfante, Eugene J Pietzak, Harry W Herr, Machele Donat, Eugene K Cha, Timothy F Donahue, Bernard H Bochner, Guido Dalbagni
BACKGROUND: The clinical significance of the plasmacytoid variant (PCV) in urothelial carcinoma (UC) is currently lacking. OBJECTIVE: To compare clinical outcomes of patients with any PCV with that of patients with pure UC treated with radical cystectomy (RC). DESIGN, SETTING, AND PARTICIPANTS: We identified 98 patients who had pathologically confirmed PCV UC and 1312 patients with pure UC and no variant history who underwent RC at our institution between 1995 and 2014...
June 27, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753837/absence-of-tumor-on-repeat-transurethral-resection-of-bladder-tumor-does-not-predict-final-pathologic-t0-stage-in-bladder-cancer-treated-with-radical-cystectomy
#20
Janet Baack Kukreja, Sima Porten, Vishnukamal Golla, Philip Levy Ho, Graciela Noguera-Gonzalez, Neema Navai, Ashish M Kamat, Colin P N Dinney, Jay B Shah
BACKGROUND: For patients with bladder cancer (BC) receiving neoadjuvant chemotherapy (NAC), complete pathologic absence of tumor (pT0) at radical cystectomy (RC) is associated with better survival. It is unclear if pT0 status can be attributed to the absence of residual disease (cT0) on transurethral resection of bladder tumor (TURBT) or to the effects of NAC. OBJECTIVE: To determine how often cT0 is associated with pT0 and identify preoperative and postoperative factors associated with survival...
January 18, 2017: European Urology Focus
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