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https://www.readbyqxmd.com/read/28276968/delivery-of-drugs-growth-factors-genes-and-stem-cells-via-intrapericardial-epicardial-and-intramyocardial-routes-for-sustained-local-targeted-therapy-of-myocardial-disease
#1
Mikhail Maslov, Stephan Foianini, Mark Lovich
Local myocardial delivery (LMD) of therapeutic agents is a promising strategy that aims to treat various myocardial pathologies. It is designed to deliver agents directly to the myocardium and minimize their extracardiac concentrations and side effects. LMD aims to enhance outcomes of existing therapies by broadening their therapeutic window and to utilize new agents that could not be otherwise be implemented systemically. Areas covered: This article provides a historical overview of six decades LMD evolution in terms of the approaches, including intrapericardial, epicardial, and intramyocardial delivery, and the wide array of classes of agents used to treat myocardial pathologies...
February 22, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28262818/phage-host-interactions-in-streptococcus-thermophilus-genome-analysis-of-phages-isolated-in-uruguay-and-ectopic-spacer-acquisition-in-crispr-array
#2
Rodrigo Achigar, Alfonso H Magadán, Denise M Tremblay, María Julia Pianzzola, Sylvain Moineau
Three cos-type virulent Streptococcus thermophilus phages were isolated from failed mozzarella production in Uruguay. Genome analyses showed that these phages are similar to those isolated elsewhere around the world. The CRISPR1 and CRISPR3 arrays of the three S. thermophilus host strains from Uruguay were also characterized and similarities were noted with previously described model strains SMQ-301, LMD-9 and DGCC7710. Spontaneous bacteriophage-insensitive S. thermophilus mutants (BIMs) were obtained after challenging the phage-sensitive wild-type strain Uy02 with the phage 128 and their CRISPR content was analyzed...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28250991/polygamy-and-risk-of-coronary-artery-disease-in-men-undergoing-angiography-an-observational-study
#3
Amin Daoulah, Amir Lotfi, Mushabab Al-Murayeh, Salem Al-Kaabi, Salem M Al-Faifi, Osama E Elkhateeb, Mohamed N Alama, Ahmad S Hersi, Ciaran M Dixon, Waleed Ahmed, Mohamed Al-Shehri, Ali Youssef, Ahmed Moustafa Elimam, Ayman S Abougalambou, Waheed Murad, Alawi A Alsheikh-Ali
Epidemiologic evidence suggests a link between psychosocial risk factors such as marital status and coronary artery disease (CAD). Polygamy (multiple concurrent wives) is a distinct marital status practiced in many countries in Asia and the Middle East, but its association with CAD is not well defined. We conducted a multicenter, observational study of consecutive patients undergoing coronary angiography during the period from April 1, 2013, to March 30, 2014. Of 1,068 enrolled patients, 687 were married men...
2017: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/28215459/leptomeningeal-metastases-presenting-exclusively-with-ocular-disturbance-in-34-patients-a-tertiary-care-cancer-hospital-experience
#4
Rory Richard Mayer, Benjamin Jay Frankfort, Ben A Strickland, James Matthew Debnam, Ian E McCutcheon, Morris D Groves, Jeffrey S Weinberg
Leptomeningeal disease (LMD) represents disseminated intracranial metastatic disease that requires early detection and initiation of therapy. Patients with LMD typically present with a variety of neurologic problems, including ocular disturbances. However, little is reported on LMD presenting exclusively with ocular-related disturbances in the absence of any other central nervous system (CNS) dysfunction. Our goal was to describe the workup for ocular disturbances in the setting of known cancer diagnosis. Retrospective case study utilizing prospectively collected database at a tertiary cancer care center for all patients with diagnosis of LMD between 2001 and 2009...
February 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28153807/amyloidosis-a-cancer-derived-paraproteinemia-and-kidney-involvement
#5
REVIEW
Jolanta Małyszko, Klaudia Kozłowska, Jacek Stanisław Małyszko
Amyloidosis is the general term describing the extracellular tissue deposition of fibrils composed of low molecular weight subunits of a variety of proteins. There are multiple different human protein precursors of amyloid fibrils. Amyloid deposits are stained using Congo Red and show typical apple-green birefringence in polarized microscopy. Nowadays, a novel technique LMD/MS technique or laser microdissection combined with mass spectrometry help to diagnose amyloidosis. Amyloidosis of the kidney is typically classified as being either one of two types: AL or AA...
January 30, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28125707/digital-pcr-improves-mutation-analysis-in-pancreas-fine-needle-aspiration-biopsy-specimens
#6
Shonan Sho, Colin M Court, Stephen Kim, David R Braxton, Shuang Hou, V Raman Muthusamy, Rabindra R Watson, Alireza Sedarat, Hsian-Rong Tseng, James S Tomlinson
Applications of precision oncology strategies rely on accurate tumor genotyping from clinically available specimens. Fine needle aspirations (FNA) are frequently obtained in cancer management and often represent the only source of tumor tissues for patients with metastatic or locally advanced diseases. However, FNAs obtained from pancreas ductal adenocarcinoma (PDAC) are often limited in cellularity and/or tumor cell purity, precluding accurate tumor genotyping in many cases. Digital PCR (dPCR) is a technology with exceptional sensitivity and low DNA template requirement, characteristics that are necessary for analyzing PDAC FNA samples...
2017: PloS One
https://www.readbyqxmd.com/read/28000105/comparing-pre-operative-stereotactic-radiosurgery-srs-to-post-operative-whole-brain-radiation-therapy-wbrt-for-resectable-brain-metastases-a-multi-institutional-analysis
#7
Kirtesh R Patel, Stuart H Burri, Danielle Boselli, James T Symanowski, Anthony L Asher, Ashley Sumrall, Robert W Fraser, Robert H Press, Jim Zhong, Richard J Cassidy, Jeffrey J Olson, Walter J Curran, Hui-Kuo G Shu, Ian R Crocker, Roshan S Prabhu
Pre-operative stereotactic radiosurgery (pre-SRS) has been shown as a viable treatment option for resectable brain metastases (BM). The aim of this study is to compare oncologic outcomes and toxicities for pre-SRS and post-operative WBRT (post-WBRT) for resectable BM. We reviewed records of consecutive patients who underwent resection of BM and either pre-SRS or post-WBRT between 2005 and 2013 at two institutions. Overall survival (OS) was calculated using the Kaplan-Meier method. Cumulative incidence was used for intracranial outcomes...
December 20, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27965537/region-specific-differences-in-amyloid-precursor-protein-expression-in-the-mouse-hippocampus
#8
Domenico Del Turco, Mandy H Paul, Jessica Schlaudraff, Meike Hick, Kristina Endres, Ulrike C Müller, Thomas Deller
The physiological role of amyloid precursor protein (APP) has been extensively investigated in the rodent hippocampus. Evidence suggests that APP plays a role in synaptic plasticity, dendritic and spine morphogenesis, neuroprotection and-at the behavioral level-hippocampus-dependent forms of learning and memory. Intriguingly, however, studies focusing on the role of APP in synaptic plasticity have reported diverging results and considerable differences in effect size between the dentate gyrus (DG) and area CA1 of the mouse hippocampus...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27776557/mammographically-dense-human-breast-tissue-stimulates-mcf10dcis-com-progression-to-invasive-lesions-and-metastasis
#9
Cecilia W Huo, Mark Waltham, Christine Khoo, Stephen B Fox, Prue Hill, Shou Chen, Grace L Chew, John T Price, Chau H Nguyen, Elizabeth D Williams, Michael Henderson, Erik W Thompson, Kara L Britt
BACKGROUND: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells compared with patient-matched low mammographic density (LMD) tissue. METHODS: Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (n = 10)...
October 25, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27662677/lmd-based-features-for-the-automatic-seizure-detection-of-eeg-signals-using-svm
#10
Tao Zhang, Wanzhong Chen
Achieving the goal of detecting seizure activity automatically using electroencephalogram (EEG) signals is of great importance and significance for the treatment of epileptic seizures. To realize this aim, a newly-developed time-frequency analytical algorithm, namely local mean decomposition (LMD), is employed in the presented study. LMD is able to decompose an arbitrary signal into a series of product functions (PFs). Primarily, the raw EEG signal is decomposed into several PFs, and then the temporal statistical and non-linear features of the first five PFs are calculated...
September 20, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27641238/gradual-downhill-running-improves-age-related-skeletal-muscle-and-bone-weakness-implication-of-autophagy-and-bone-morphogenetic-proteins
#11
Jeong-Seok Kim, Young-Hee Lee, Ho-Keun Yi
What is the central question of this study? Exercise training by running has an effect on age-related muscle and bone wasting that improves physical activity and quality of life in the elderly. However, the effect of downhill running on age-related muscle and bone wasting, and its mechanisms, are unclear. What is the main finding and its importance? Gradual downhill running can improve skeletal muscle growth and bone formation by enhancing autophagy and bone morphogenetic protein signalling in aged rats. Therefore, downhill running exercise might be a practical intervention to improve skeletal muscle and bone protection in the elderly...
December 1, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27629839/diabetic-patients-with-an-acute-myocardial-infarction-in-terms-of-risk-factors-and-comorbidities-management-characteristics-of-the-highest-risk-individuals
#12
Józefa Dąbek, Mariusz Bałys, Michał Majewski, Zbigniew T Gąsior
BACKGROUND: Patients with diabetes mellitus (DM) and acute myocardial infarction (AMI) are heterogeneous individuals with different clinical status compared to patients without DM. OBJECTIVES: The aim of this study was to analyze the group of diabetic patients with ST-segment elevation MI (STEMI) or non-ST-segment elevation infarction (NSTEMI) including risk factors, medical history, laboratory findings, advancement of coronary vessel atherosclerosis, and diagnostics and therapeutic modalities performed...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27604558/identification-of-15-novel-partial-shox-deletions-and-13-partial-duplications-and-a-review-of-the-literature-reveals-intron-3-to-be-a-hotspot-region
#13
Sara Benito-Sanz, Alberta Belinchon-Martínez, Miriam Aza-Carmona, Carolina de la Torre, Celine Huber, Isabel González-Casado, Judith L Ross, N Simon Thomas, Andrew R Zinn, Valerie Cormier-Daire, Karen E Heath
Short stature homeobox gene (SHOX) is located in the pseudoautosomal region 1 of the sex chromosomes. It encodes a transcription factor implicated in the skeletal growth. Point mutations, deletions or duplications of SHOX or its transcriptional regulatory elements are associated with two skeletal dysplasias, Léri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LMD), as well as in a small proportion of idiopathic short stature (ISS) individuals. We have identified a total of 15 partial SHOX deletions and 13 partial SHOX duplications in LWD, LMD and ISS patients referred for routine SHOX diagnostics during a 10 year period (2004-2014)...
September 8, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27590622/human-glandular-organoid-formation-in-murine-engineering-chambers-after-collagenase-digestion-and-flow-cytometry-isolation-of-normal-human-breast-tissue-single-cells
#14
Cecilia W Huo, Dexing Huang, Grace L Chew, Prue Hill, Ambika Vohora, Wendy V Ingman, Danielle J Glynn, Nathan Godde, Michael A Henderson, Erik W Thompson, Kara L Britt
Women with high mammographic density (MD) are at increased risk of breast cancer (BC) after adjustment for age and body mass index. We have developed a murine biochamber model in which both high MD (HMD) and low MD (LMD) tissue can be propagated. Here, we tested whether cells isolated by collagenase digestion and fluorescence-activated cell sorting (FACS) from normal breast can be reconstituted in our biochamber model, which would allow cell-specific manipulations to be tested. Fresh breast tissue was collected from women (n = 7) undergoing prophylactic mastectomy...
November 2016: Cell Biology International
https://www.readbyqxmd.com/read/27585503/outcomes-after-percutaneous-coronary-intervention-or-bypass-surgery-in-patients-with-unprotected-left-main-disease
#15
Rafael Cavalcante, Yohei Sotomi, Cheol W Lee, Jung-Min Ahn, Vasim Farooq, Hiroki Tateishi, Erhan Tenekecioglu, Yaping Zeng, Pannipa Suwannasom, Carlos Collet, Felipe N Albuquerque, Yoshinobu Onuma, Seung-Jung Park, Patrick W Serruys
BACKGROUND: Currently available randomized data on the comparison between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for the treatment of unprotected left main coronary disease (LMD) lacks statistical power due to low numbers of patients enrolled. OBJECTIVES: This study assessed long-term outcomes of PCI and CABG for the treatment of LMD in specific subgroups according to disease anatomic complexity. METHODS: We conducted a pooled analysis of individual patient-level data of the LMD patients included in the PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) and SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) trials...
September 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27536380/maternal-diet-quality-and-nutrient-intake-in-the-gestational-period-results-from-the-delta-healthy-sprouts-comparative-impact-trial
#16
Lisa M Tussing-Humphreys, Jessica L Thomson, Melissa H Goodman, Sarah Olender
BACKGROUND: A woman's diet while pregnant can play an important role in her reproductive health as well as the health of her unborn child. Diet quality and nutrient intake amongst pregnant women residing in the rural Lower Mississippi Delta (LMD) region of the United States is inadequate. The Delta Healthy Sprouts Project was designed to test the comparative impact of two home visiting programs on weight status, dietary intake, and health behaviors of women and their infants residing in the LMD region...
2016: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/27486224/development-and-application-of-a-novel-model-system-to-study-active-and-passive-tumor-targeting
#17
Amarnath Mukherjee, Binod Kumar, Koji Hatano, Luisa M Russell, Bruce J Trock, Peter C Searson, Alan K Meeker, Martin G Pomper, Shawn E Lupold
Macromolecular reagents can be targeted to tumors through active and passive mechanisms. "Active" targeting involves moieties, such as receptor ligands, to direct tumor cell binding, whereas "passive" targeting relies on long reagent circulating half-life, abnormal tumor vasculature, and poor lymphatic drainage for tumor entrapment. Here, we sought to study the impact of reagent circulating half-life on "active" and "passive" tumor uptake. The humanized prostate-specific membrane antigen (PSMA)-targeting antibody HuJ591 was used as the "active" targeting agent...
October 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27418946/tissues-based-chemical-profiling-and-semi-quantitative-analysis-of-bioactive-components-in-the-root-of-salvia-miltiorrhiza-bunge-by-using-laser-microdissection-system-combined-with-uplc-q-tof-ms
#18
Wenjian Xie, Hongjie Zhang, Jianguo Zeng, Hubiao Chen, Zhongzhen Zhao, Zhitao Liang
BACKGROUND: The dry root of Salvia miltiorrhiza Bunge (Danshen in Chinese) is an used-widely traditional Chinese herbal medicine with and promising efficacy. This herbal plant has been extensively cultivated in China. Currently, people usually rely on its morphological features to evalaute its pharmaceutical quality. In this study, laser micro-dissection system (LMD) was applied to isolate single fresh tissue of root of S. miltiorrhiza. Under fluorescent microscopic model, five tissues namely cork, cortex, phloem, xylem ray and vessel were well recognized and isolated accurately by LMD, respectively and then the distribution pattern of the major bioactive compounds in various tissues was investigated by ultra-performance liquid chromatography-quadrupole/time of flight-mass spectrometry, which aims to validate the traditional experience on evaluating pharmaceutical quality of Danshen by morphological features...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27399113/integrative-radiogenomic-analysis-for-genomic-signatures-in-glioblastomas-presenting-leptomeningeal-dissemination
#19
Hye Jin You, Ho-Young Park, Jinkuk Kim, In-Hee Lee, Ho Jun Seol, Jung-Il Lee, Sung Tae Kim, Doo-Sik Kong, Do-Hyun Nam
Despite therapeutic advances, the prognosis for glioblastoma (GBM) remains poor. In particular, leptomeningeal dissemination (LMD) has a dismal prognosis. The aim of this study was to identify tumor molecular phenotype, which has a great propensity to develop LMD. Between May 2004 and December 2012, a total of 145 GBM tumor samples were obtained from data registry. A total of 20 of the 145 patients with GBM were found to develop LMD. A specialized radiologist confirmed the diagnosis of LMD on magnetic resonance imaging...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27387430/unveiling-of-mirna-expression-patterns-in-purkinje-cells-during-development
#20
Lukas Pieczora, Lara Stracke, Matthias Vorgerd, Stephan Hahn, Carsten Theiss, Verena Theis
MicroRNAs (miRNAs) are short noncoding RNAs of 19-25 nucleotides in length that regulate gene expression at the post-transcriptional level. Dysregulation of miRNAs is associated with many disorders and neurodegenerative diseases affecting numerous different pathways and processes, of which many have not yet been completely explored. Recent studies even indicate a crucial role of miRNAs during brain development, with differential expression patterns of several miRNAs seen in both developing and mature cells...
July 7, 2016: Cerebellum
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