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https://www.readbyqxmd.com/read/29119531/the-non-operative-management-of-asymptomatic-liver-hydatids-ending-echinococcophobia
#1
Farrokh Saidi, Farrokh Habibzadeh
BACKGROUND: Cystic echinococcosis is common in many countries and involves the liver in 75% of cases. The current belief is that all incidentally discovered asymptomatic liver hydatids must be subjected to some types of interventional treatments pre-emptively for fear of some presumably impending complications. We conducted this study to assess the prognosis of patients with liver hydatids without any surgical interventions. Furthermore, we tried to predict the outcome of the cyst using two radiological signs...
November 8, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29066948/is-arc-mrna-unique-a-search-for-mrnas-that-localize-to-the-distal-dendrites-of-dentate-gyrus-granule-cells-following-neural-activity
#2
Christopher A de Solis, Anna A Morales, Matthew P Hosek, Alex C Partin, Jonathan E Ploski
There have been several attempts to identify which RNAs are localized to dendrites; however, no study has determined which RNAs localize to the dendrites following the induction of synaptic activity. We sought to identify all RNA transcripts that localize to the distal dendrites of dentate gyrus granule cells following unilateral high frequency stimulation of the perforant pathway (pp-HFS) using Sprague Dawley rats. We then utilized laser microdissection (LMD) to very accurately dissect out the distal 2/3rds of the molecular layer (ML), which contains these dendrites, without contamination from the granule cell layer, 2 and 4 h post pp-HFS...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29034509/3d-diffusion-weighted-129-xe-mri-for-whole-lung-morphometry
#3
Ho-Fung Chan, Neil J Stewart, Graham Norquay, Guilhem J Collier, Jim M Wild
PURPOSE: To obtain whole lung morphometry measurements from (129) Xe in a single breath-hold with 3D multiple b-value (129) Xe diffusion-weighted MRI (DW-MRI) with an empirically optimized diffusion time and compressed sensing for scan acceleration. METHODS: Prospective three-fold undersampled 3D multiple b-value hyperpolarized (129) Xe DW-MRI datasets were acquired, and the diffusion time (Δ) was iterated so as to provide diffusive length scale (LmD ) estimates from the stretched exponential model (SEM) that are comparable to those from (3) He...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28989744/mixed-matrix-membranes-with-enhanced-antifouling-activity-probing-the-surface-tailoring-potential-of-tiron-and-chromotropic-acid-for-nano-tio2
#4
Avishek Pal, T K Dey, A K Debnath, Bharat Bhushan, A K Sahu, R C Bindal, Soumitra Kar
Mixed-matrix membranes (MMMs) were developed by impregnating organofunctionalized nanoadditives within fouling-susceptible polysulfone matrix following the non-solvent induced phase separation (NIPS) method. The facile functionalization of nanoparticles of anatase TiO2 (nano-TiO2) by using two different organoligands, viz. Tiron and chromotropic acid, was carried out to obtain organofunctionalized nanoadditives, FT-nano-TiO2 and FC-nano-TiO2, respectively. The structural features of nanoadditives were evaluated by X-ray diffraction, X-ray photoelectron spectroscopy, Raman and Fourier transform infrared spectroscopy, which established that Tiron leads to the blending of chelating and bridging bidentate geometries for FT-nano-TiO2, whereas chromotropic acid produces bridging bidentate as well as monodentate geometries for FC-nano-TiO2...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28974415/hypofractionated-stereotactic-radiation-therapy-to-the-resection-bed-for-intracranial-metastases
#5
Audrey Keller, Mélanie Doré, Hélène Cebula, François Thillays, François Proust, Ioana Darié, Stéphane-André Martin, Gregory Delpon, François Lefebvre, Georges Noël, Delphine Antoni
PURPOSE: To retrospectively report the outcomes of a large multicenter cohort of patients treated with surgery and hypofractionated stereotactic radiation therapy (HFSRT) to the resection cavities of brain metastases (BMs). METHODS AND MATERIALS: Between March 2008 and February 2015, 181 patients with no prior whole-brain radiation therapy (WBRT) were treated by HFSRT to the surgical bed of BM at the dose of 33 Gy (3 × 11 Gy). The primary endpoint was local control...
August 19, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28968585/treatment-and-prognosis-of-leptomeningeal-disease-secondary-to-metastatic-breast-cancer-a-single-centre-experience
#6
Belinda Kingston, Hamzeh Kayhanian, Chloe Brooks, Nicola Cox, Narda Chaabouni, Stefania Redana, Eleftheria Kalaitzaki, Ian Smith, Mary O'Brien, Stephen Johnston, Marina Parton, Jill Noble, Susie Stanway, Alistair Ring, Nicholas Turner, Alicia Okines
PURPOSE: Leptomeningeal disease (LMD) is an uncommon complication of advanced breast cancer. The prognosis is poor, and although radiotherapy (RT), systemic and intra-thecal (IT) chemotherapy are accepted treatment modalities, efficacy data are limited. This study was designed to evaluate potential predictors of survival in this patient group. METHODS: Breast cancer patients with LMD diagnosed by MRI in a 10-year period (2004-2014) were identified from electronic patient records...
December 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28967051/additive-manufacturing-of-titanium-alloys-in-the-biomedical-field-processes-properties-and-applications
#7
Francesco Trevisan, Flaviana Calignano, Alberta Aversa, Giulio Marchese, Mariangela Lombardi, Sara Biamino, Daniele Ugues, Diego Manfredi
The mechanical properties and biocompatibility of titanium alloy medical devices and implants produced by additive manufacturing (AM) technologies - in particular, selective laser melting (SLM), electron beam melting (EBM) and laser metal deposition (LMD) - have been investigated by several researchers demonstrating how these innovative processes are able to fulfil medical requirements for clinical applications. This work reviews the advantages given by these technologies, which include the possibility to create porous complex structures to improve osseointegration and mechanical properties (best match with the modulus of elasticity of local bone), to lower processing costs, to produce custom-made implants according to the data for the patient acquired via computed tomography and to reduce waste...
September 25, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28935572/macrophage-infiltration-is-a-causative-factor-for-ligamentum-flavum-hypertrophy-through-the-activation-of-collagen-production-in-fibroblasts
#8
Takeyuki Saito, Masamitsu Hara, Hiromi Kumamaru, Kazu Kobayakawa, Kazuya Yokota, Ken Kijima, Shingo Yoshizaki, Katsumi Harimaya, Yoshihiro Matsumoto, Kenichi Kawaguchi, Mitsumasa Hayashida, Yutaka Inagaki, Keiichiro Shiba, Yasuharu Nakashima, Seiji Okada
Ligamentum flavum (LF) hypertrophy causes lumbar spinal canal stenosis, leading to leg pain and disability in activities of daily living in elderly individuals. Although previous studies have been performed on LF hypertrophy, its pathomechanisms have not been fully elucidated. In this study, we demonstrated that infiltrating macrophages were a causative factor for LF hypertrophy. Induction of macrophages into the mouse LF by applying a microinjury resulted in LF hypertrophy along with collagen accumulation and fibroblasts proliferation at the injured site, which were very similar to the characteristics observed in the severely hypertrophied LF of human...
September 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28900274/characterization-and-identification-of-a-woody-lesion-mimic-mutant-lmd-showing-defence-response-and-resistance-to-alternaria-alternate-in-birch
#9
Ranhong Li, Su Chen, Guifeng Liu, Rui Han, Jing Jiang
Lesion mimic mutants (LMM) usually show spontaneous cell death and enhanced defence responses similar to hypersensitive response (HR) in plants. Many LMM have been reported in rice, wheat, maize, barley, Arabidopsis, etc., but little was reported in xylophyta. BpGH3.5 is an early auxin-response factor which regulates root elongation in birch. Here, we found a T-DNA insertion mutant in a BpGH3.5 transgenic line named lmd showing typical LMM characters and early leaf senescence in Betula platyphylla × B...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838092/percutaneous-coronary-intervention-vs-coronary-artery-bypass-grafting-for-left-main-revascularization-an-updated-meta-analysis
#10
Navkaranbir S Bajaj, Nirav Patel, Rajat Kalra, Peter Marogil, Ashwanikumar Bhardwaj, Garima Arora, Pankaj Arora
Aims: The optimal revascularization strategy for left main coronary artery disease (LMD) remains controversial, especially with two recent randomized controlled trials showing conflicting results. We sought to address this controversy with our analysis. Methods and results: Comprehensive literature search was performed. We compared percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for LMD revascularization using standard meta-analytic techniques...
July 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28818382/cell-specific-expression-of-plant-nutrient-transporter-genes-in-orchid-mycorrhizae
#11
Valeria Fochi, Nicole Falla, Mariangela Girlanda, Silvia Perotto, Raffaella Balestrini
Orchid mycorrhizal protocorms and roots are heterogeneous structures composed of different plant cell-types, where cells colonized by intracellular fungal coils (the pelotons) are close to non-colonized plant cells. Moreover, the fungal coils undergo rapid turnover inside the colonized cells, so that plant cells containing coils at different developmental stages can be observed in the same tissue section. Here, we have investigated by laser microdissection (LMD) the localization of specific plant gene transcripts in different cell-type populations collected from mycorrhizal protocorms and roots of the Mediterranean orchid Serapias vomeracea colonized by Tulasnella calospora...
October 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28811952/divorce-and-severity-of-coronary-artery-disease-a-multicenter-study
#12
Amin Daoulah, Mushabab Al-Murayeh, Salem Al-Kaabi, Amir Lotfi, Osama E Elkhateeb, Salem M Al-Faifi, Saleh Alqahtani, James Stewart, Jon Heavey, William T Hurley, Mohamed N Alama, Mazen Faden, Mohamed Al-Shehri, Ali Youssef, Alawi A Alsheikh-Ali
The association between marital status and coronary artery disease (CAD) is supported by numerous epidemiological studies. While divorce may have an adverse effect on cardiac outcomes, the relationship between divorce and severe CAD is unclear. We conducted a multicenter, observational study of consecutive patients undergoing coronary angiography during the period between April 1, 2013, and March 30, 2014. Of 1,068 patients, 124 (12%) were divorced. Divorce was more frequent among women (27%) compared to men (6%)...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/28802798/most-common-sites-on-mri-of-intracranial-neoplastic-leptomeningeal-disease
#13
J Matthew Debnam, Rory R Mayer, T Linda Chi, Leena Ketonen, Jeffrey S Weinberg, Wei Wei, Morris D Groves, Nandita Guha-Thakurta
Neoplastic leptomeningeal disease (LMD) represents infiltration of the leptomeninges by tumor cells. Knowledge of the frequencies of locations of LMD on MRI may assist in early detection, help elucidate the process of leptomeningeal spread of cancer and understand how LMD affects the central nervous system. Our goal was to identify intracranial sites of neoplastic LMD predilection on MRI in patients with cytologically-proven LMD. The presence of FLAIR signal hyperintensity and T1-weighted post-contrast enhancement in the sulci of the supratentorial compartment and cerebellum and enhancement of the cranial nerves (CNs), basal cisterns, pituitary stalk, and ependymal surface of the lateral ventricles, as well as the presence of parenchymal metastasis were recorded...
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28801933/maldi-imaging-guided-microproteomic-analyses-of-heterogeneous-breast-tumors-a-pilot-study
#14
Deborah Alberts, Charles Pottier, Nicolas Smargiasso, Dominique Baiwir, Gabriel Mazzucchelli, Philippe Delvenne, Mark Kriegsmann, Daniel Kazdal, Arne Warth, Edwin De Pauw, Rémi Longuespée
PURPOSE: Matrix-assisted laser desorption/ionization (MALDI) imaging is an ideal tool to study intratumor heterogeneity (ITH) and its implication in prognostic stratification of patients. However there are some drawbacks concerning protein identification. On the other hand, laser microdissection (LMD)-based microproteomics allows retrieving thousands of protein identifications from small tissue pieces. As a proof of concept, we combined these two complementary approaches to analyze heterogeneous regions in breast tumors...
August 11, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28777961/ultra-sensitive-nh3-sensor-based-on-flower-shaped-sns2-nanostructures-with-sub-ppm-detection-ability
#15
Ya Xiong, Wangwang Xu, Degong Ding, Wenbo Lu, Lei Zhu, Zongye Zhu, Ying Wang, Qingzhong Xue
Layered metal dichalcogenides (LMDs) semiconducting materials have recently attracted tremendous attention as high performance gas sensors due to unique chemical and physical properties of thin layers. Here, three-dimensional SnS2 nanoflower structures assembled with thin nanosheets were synthesized via a facile solvothermal process. When applied to detect 100ppm NH3 at 200°C, the SnS2 based sensor exhibited high response value of 7.4, short response/recovery time of 40.6s/624s. Moreover, the sensor demonstrated a low detection limit of 0...
July 25, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28772369/comparison-of-maraging-steel-micro-and-nanostructure-produced-conventionally-and-by-laser-additive-manufacturing
#16
Eric A Jägle, Zhendong Sheng, Philipp Kürnsteiner, Sörn Ocylok, Andreas Weisheit, Dierk Raabe
Maraging steels are used to produce tools by Additive Manufacturing (AM) methods such as Laser Metal Deposition (LMD) and Selective Laser Melting (SLM). Although it is well established that dense parts can be produced by AM, the influence of the AM process on the microstructure-in particular the content of retained and reversed austenite as well as the nanostructure, especially the precipitate density and chemistry, are not yet explored. Here, we study these features using microhardness measurements, Optical Microscopy, Electron Backscatter Diffraction (EBSD), Energy Dispersive Spectroscopy (EDS), and Atom Probe Tomography (APT) in the as-produced state and during ageing heat treatment...
December 24, 2016: Materials
https://www.readbyqxmd.com/read/28702092/pat-h-ms-coupled-with-laser-microdissection-to-study-histone-post-translational-modifications-in-selected-cell-populations-from-pathology-samples
#17
Roberta Noberini, Rémi Longuespée, Cristina Richichi, Giancarlo Pruneri, Mark Kriegsmann, Giuliana Pelicci, Tiziana Bonaldi
BACKGROUND: Aberrations in histone post-translational modifications (hPTMs) have been linked with various pathologies, including cancer, and could not only represent useful biomarkers but also suggest possible targetable epigenetic mechanisms. We have recently developed an approach, termed pathology tissue analysis of histones by mass spectrometry (PAT-H-MS), that allows performing a comprehensive and quantitative analysis of histone PTMs from formalin-fixed paraffin-embedded pathology samples...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28650055/non-planar-vertical-photodetectors-based-on-free-standing-two-dimensional-sns2-nanosheets
#18
Guangbo Liu, Zhonghua Li, Xiaoshuang Chen, Wei Zheng, Wei Feng, Mingjin Dai, Dechang Jia, Yu Zhou, PingAn Hu
The development trend of modern electronics and optoelectronics is towards continuous high integration and miniaturization. Using vertical configurations with three-dimensional geometry, it is easy to establish a higher integration density than the traditional planar one, and thus, this technology shows great promise for designing the next-generation electronics/optoelectronic devices. Two-dimensional (2D) layered metal dichalcogenides (2D-LMDs) are important building blocks for electronic/optoelectronic devices, where they are usually grown in parallel to the substrates during chemical vapor deposition (CVD), and consequently they are solely exploited to fabricate lateral structure devices with planar geometry...
July 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28592699/lower-affinity-of-isradipine-for-l-type-ca-2-channels-during-substantia-nigra-dopamine-neuron-like-activity-implications-for-neuroprotection-in-parkinson-s-disease
#19
Nadine J Ortner, Gabriella Bock, Antonios Dougalis, Maria Kharitonova, Johanna Duda, Simon Hess, Petronel Tuluc, Thomas Pomberger, Nadia Stefanova, Florian Pitterl, Thomas Ciossek, Herbert Oberacher, Henning J Draheim, Peter Kloppenburg, Birgit Liss, Jörg Striessnig
Ca(2+)-influx through L-type Ca(2+)-channels (LTCCs) is associated with activity-related stressful oscillations of Ca(2+) levels within dopaminergic (DA) neurons in the substantia nigra (SN), which may contribute to their selective degeneration in Parkinson's disease (PD). LTCC blockers were neuroprotective in mouse neurotoxin models of PD, and isradipine is currently undergoing testing in a phase III clinical trial in early PD. We report no evidence for neuroprotection by in vivo pretreatment with therapeutically relevant isradipine plasma levels, or Cav1...
July 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28553494/molecular-dynamics-and-charge-transport-in-organic-semiconductors-a-classical-approach-to-modeling-electron-transfer
#20
Kenley M Pelzer, Álvaro Vázquez-Mayagoitia, Laura E Ratcliff, Sergei Tretiak, Raymond A Bair, Stephen K Gray, Troy Van Voorhis, Ross E Larsen, Seth B Darling
Organic photovoltaics (OPVs) are a promising carbon-neutral energy conversion technology, with recent improvements pushing power conversion efficiencies over 10%. A major factor limiting OPV performance is inefficiency of charge transport in organic semiconducting materials (OSCs). Due to strong coupling with lattice degrees of freedom, the charges form polarons, localized quasi-particles comprised of charges dressed with phonons. These polarons can be conceptualized as pseudo-atoms with a greater effective mass than a bare charge...
April 1, 2017: Chemical Science
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