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https://www.readbyqxmd.com/read/28727420/bio-inspired-development-of-p-st-maa-avermectins-nanoparticles-with-high-affinity-for-foliage-to-enhance-folia-retention
#1
Jie Liang, Manli Yu, Liya Guo, Bo Cui, Xiang Zhao, Changjiao Sun, Yan Wang, Guoqiang Liu, Haixin Cui, Zhanghua Zeng
Pesticides are chemical or biological substances to control pests and protect crop yield. Most pesticides suffering from large amounts of losses in the environment, lead to damage of ecological systems and food pollution. To reduce their losses and increase utilization rate, we have developed a bio-inspired by mussel avermectins nanoparticles (P(St-MAA)-Av-Cat) with strong adhesion to crop foliage by emulsion-solvent evaporation method and chemical modification. They were near spheres sharpness with a diameter around 120 nm...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28726870/highly-efficient-photosensitizers-with-aggregation-induced-emission-characteristics-obtained-through-precise-molecular-design
#2
Shidang Xu, Wenbo Wu, Xiaolei Cai, Chong-Jing Zhang, Youyong Yuan, Jing Liang, Guangxue Feng, Purnima Manghnani, Bin Liu
We herein report a new strategy to obtain highly efficient photosensitizers (PSs) by reducing the singlet-triplet energy gap (ΔEST) and blocking the non-radiative decay pathways. Through precise molecular design, TP1-8 were synthesized to exhibit predictable properties including moderate to high photosensitizing efficacy, tunable absorption and emission wavelengths and aggregation-induced emission characteristics.
July 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28725533/controllable-photodynamic-therapy-implemented-by-regulating-singlet-oxygen-efficiency
#3
REVIEW
Wenting Wu, Xiaodong Shao, Jianzhang Zhao, Mingbo Wu
With singlet oxygen ((1)O2) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, H2O2 and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e...
July 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28723923/on-the-mechanism-of-candida-tropicalis-biofilm-reduction-by-the-combined-action-of-naturally-occurring-anthraquinones-and-blue-light
#4
Juliana Marioni, Roger Bresolí-Obach, Montserrat Agut, Laura R Comini, José L Cabrera, María G Paraje, Santi Nonell, Susana C Núñez Montoya
The photoprocesses involved in the photo-induced Candida tropicalis biofilm reduction by two natural anthraquinones (AQs), rubiadin (1) and rubiadin-1-methyl ether (2), were examined. Production of singlet oxygen (1O2) and of superoxide radical anion (O2•-) was studied. Although it was not possible to detect the triplet state absorption of any AQs in biofilms, observation of 1O2 phosphorescence incubated with deuterated Phosphate Buffer Solution, indicated that this species is actually formed in biofilms...
2017: PloS One
https://www.readbyqxmd.com/read/28723895/visible-light-driven-methane-formation-from-co2-with-a-molecular-iron-catalyst
#5
Heng Rao, Luciana C Schmidt, Julien Bonin, Marc Robert
Converting CO2 into fuel or chemical feedstock compounds could in principle reduce fossil fuel consumption and climate-changing CO2 emissions. One strategy aims for electrochemical conversions powered by electricity from renewable sources, but photochemical approaches driven by sunlight are also conceivable. A considerable challenge in both approaches is the development of efficient and selective catalysts, ideally based on cheap and Earth-abundant elements rather than expensive precious metals. Of the molecular photo- and electrocatalysts reported, only a few catalysts are stable and selective for CO2 reduction; moreover, these catalysts produce primarily CO or HCOOH, and catalysts capable of generating even low to moderate yields of highly reduced hydrocarbons remain rare...
July 17, 2017: Nature
https://www.readbyqxmd.com/read/28722126/investigating-the-effect-of-poly-l-lactic-acid-nanoparticles-carrying-hypericin-on-the-flow-biased-diffusive-motion-of-hela-cell-organelles
#6
Rozhin Penjweini, Sarah Deville, Omid Haji Maghsoudi, Kristof Notelaers, Anitha Ethirajan, Marcel Ameloot
OBJECTIVES: In this study, we investigate in human cervical epithelial HeLa cells the intracellular dynamics and the mutual interaction with the organelles of the poly-l-lactic acid nanoparticles (PLLA NPs) carrying the naturally occurring hydrophobic photosensitizer hypericin. METHODS: Temporal and spatiotemporal image correlation spectroscopy was used for the assessment of the intracellular diffusion and directed motion of the nanocarriers by tracking the hypericin fluorescence...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28721930/pharmacoresistant-epileptic-eyelid-twitching-in-a-child-with-a-mutation-in-syngap1
#7
Tetsuya Okazaki, Yoshiaki Saito, Rika Hiraiwa, Shinji Saitoh, Masachika Kai, Kaori Adachi, Yoko Nishimura, Eiji Nanba, Yoshihiro Maegaki
SYNGAP1 gene mutation has been associated with epilepsy which is often drug resistant, with seizure types including eyelid myoclonia. However, detailed descriptions, including ictal video-EEG, have not been reported. We report the case of a 4-year-old boy who developed recurrent epileptic eyelid twitching at 1 year and 5 months of age. Seizures gradually increased in frequency to more than 50 times per day and manifested with upward eye deviation, motion arrest, loss of consciousness, and eyelid twitching lasting for five seconds...
July 19, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28717198/controlled-modification-of-biomolecules-by-ultrashort-laser-pulses-in-polar-liquids
#8
Vitaly Gruzdev, Dmitry Korkin, Brian P Mooney, Jesper F Havelund, Ian Max Møller, Jay J Thelen
Targeted chemical modification of peptides and proteins by laser pulses in a biologically relevant environment, i.e. aqueous solvent at room temperature, allows for accurate control of biological processes. However, the traditional laser methods of control of chemical reactions are applicable only to a small class of photosensitive biomolecules because of strong and ultrafast perturbations from biomolecule-solvent interactions. Here, we report excitation of harmonics of vibration modes of solvent molecules by femtosecond laser pulses to produce controlled chemical modifications of non-photosensitive peptides and proteins in polar liquids under room conditions...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716739/phototoxicity-in-a-laryngeal-cancer-cell-line-enhanced-by-a-targeting-amphiphilic-chlorin-photosensitizer
#9
Milene N O Moritz, Carlos Rossa, Kleber T de Oliveira, Marciana P Uliana, Janice R Perussi
BACKGROUND: Photodynamic therapy (PDT) has been established in several countries as an alternative therapy for the treatment of various malignancies. This therapy involves the incorporation of a photosensitizer (PS) that is activated by visible light and form reactive oxygen species leading to target cell death by apoptosis or necrosis. Previously, our group has demonstrated that CHL-T (semi-synthesized from chlorophyll a and containing a linked solubilizing group TRISMA(®)) presented a pronounced potential to induce death in HeLa cell line after PDT...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716738/photodynamic-therapy-and-pain-a-systematic-review
#10
Jennifer Maria Ang, Irbaz Bin Riaz, Muhammad Umar Kamal, Gyorgy Paragh, Nathalie C Zeitouni
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and early skin cancers, and the only office procedure to control field cancerization. Procedure-associated pain limits widespread PDT use and by early termination of treatment can decrease overall therapeutic efficacy. Here we review and assess reported interventions on PDT-associated pain, in order to identify the most promising methods to manage treatment-associated pain and identify focus for future studies. Literature search was performed using MEDLINE, EMBASE, and the Cochrane Library by two independent reviewers to select publications that assessed and compared pain quantitatively during PDT treatment for actinic keratoses, basal cell carcinomas, and/or in situ squamous cell carcinomas...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716667/pupillometric-evaluation-of-the-melanopsin-containing-retinal-ganglion-cells-in-mitochondrial-and-non-mitochondrial-optic-neuropathies
#11
Shakoor Ba-Ali, Henrik Lund-Andersen
In recent years, chromatic pupillometry is used in humans to evaluate the activity of melanopsin expressing intrinsic photosensitive retinal ganglion cells (ipRGCs). Blue light is used to stimulate the ipRGCs and red light activates the rod/cone photoreceptors. The late re-dilation phase of pupillary light reflex is primarily driven by the ipRGCs. Optic neuropathies i.e. Leber hereditary optic neuropathy (LHON), autosomal dominant optic atrophy (ADOA), nonarteritic anterior ischemic optic neuropathy (NAION), glaucoma, optic neuritis and idiopathic intracranial hypertension (IIH) are among the diseases, which have been subject to pupillometric studies...
July 14, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28715781/effects-of-blue-or-violet-light-on-the-inactivation-of-staphylococcus-aureus-by-riboflavin-5-phosphate-photolysis
#12
Tak-Wah Wong, Chien-Wei Cheng, Zong-Jhe Hsieh, Ji-Yuan Liang
The light sensitive compound riboflavin-5'-phosphate (or flavin mononucleotide, FMN) generates reactive oxygen species (ROS) upon photo-irradiation. FMN is required by all flavoproteins because it is a cofactor of biological blue-light receptors. The photochemical effects of FMN after irradiation by blue or violet light on the inactivation of Staphylococcus aureus strains, including a methicillin-resistant strain (MRSA), were investigated in this study. Upon blue- or violet-light photo-treatment, FMN was shown to inactivate S...
July 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28715587/a-quantitative-and-qualitative-exploration-of-photoaversion-in-achromatopsia
#13
Jonathan Aboshiha, Neruban Kumaran, Angelos Kalitzeos, Chris Hogg, Gary Rubin, Michel Michaelides
Purpose: Photoaversion (PA) is a disabling and ubiquitous feature of achromatopsia (ACHM). We aimed to help define the characteristics of this important symptom, and present the first published assessment of its impact on patients' lives, as well as quantitative and qualitative PA assessments. Methods: Molecularly confirmed ACHM subjects were assessed for PA using four tasks: structured survey of patient experience, novel quantitative subjective measurement of PA, visual acuities in differing ambient lighting, and objective palpebral aperture-related PA testing...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28715120/characterization-of-a-multiple-particle-delivery-complex-and-determination-of-cellular-photodamage-in-skin-fibroblast-and-breast-cancer-cell-lines
#14
Ivan Mfouo-Tynga, Nicolette Nadene Houreld, Heidi Abrahamse
Zinc metallized Phthalocyanine (ZnPcSmix ), a potent photosensitizer (PS), is conjugated to gold dendrimer encapsulated nanoparticles (AuDENPs) in order to improve the efficacy of Photodynamic therapy (PDT) using MCF-7 breast cancer cells and WS1 fibroblast cells as a control. Both ZnPcSmix and AuDENPs are mixed in a nitrogen atmosphere for 48 h and characterization analysis conducted using ultra violet visible (UV-vis) spectrometry for spectral properties, transmission electron microscopy (TEM) for morphological features and zeta potential measurement for surface stability and size distribution of the compound obtained or of the multiple particles delivery complex (MPDC)...
July 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28715037/enhanced-current-rectification-and-self-powered-photoresponse-in-multilayer-p-mote2-n-mos2-van-der-waals-heterojunctions
#15
Bin Wang, Shengxue Yang, Cong Wang, Minghui Wu, Li Huang, Qian Liu, Chengbao Jiang
Vertically stacked van der Waals (vdW) heterojunctions based on two-dimensional (2D) transition metal dichalcogenides (TMDs) have attracted a great deal of attention and have created a powerful new material platform for novel, high-performance electronic and optoelectronic devices. Here, we report the construction of multilayer p-MoTe2/n-MoS2 vdW heterostructures with remarkable rectification behavior, self-powered photoresponse and distinct photosensitivity at different laser wavelengths and power densities...
July 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28714507/postsynthetic-modification-of-a-zirconium-metal-organic-framework-at-the-inorganic-secondary-building-unit-with-diphenylphosphinic-acid-for-increased-photosensitizing-properties-and-stability
#16
J Hynek, S Ondrušová, D Bůžek, P Kovář, J Rathouský, J Demel
A zirconium metal-organic framework (MOF) PCN-222 was postsynthetically modified with diphenylphosphinic acid, resulting in an increased stability when activated from water and 4 times higher photosensitizing properties for singlet oxygen production. The phosphinic acid did not compromise the crystallinity of the MOF but made strong bonds with the zirconia secondary building units.
July 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28714384/chemistry-in-the-bioactivity-of-chlorophylls-an-overview
#17
Antonio Pérez-Gálvez, Isabel Viera, María Roca
BACKGROUND: In addition to the considerable number of different chlorophyll structures originated naturally, prominent research is made to produce new specific semi-synthetic structures. The final target is to obtain chlorophyll derivatives with even better bioactive properties than those of the natural parent compounds. METHOD: A detailed, extensive and critic literature search have been made in Web of ScienceTM Results: Great efforts are applying to optimize the function of chlorophyll-based photosensitizers, to understand the molecular mechanisms of the antioxidant and antigenotoxic properties of chlorophyll derivatives and, lastly, to investigate new biological actions of them...
July 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28711638/the-alteration-of-temoporpfin-distribution-in-multicellular-tumor-spheroids-by-%C3%AE-cyclodextrins
#18
Ilya Yakavets, Igor Yankovsky, Marie Millard, Laureline Lamy, Henri-Pierre Lassalle, Arno Wiehe, Vladimir Zorin, Lina Bezdetnaya
To be effective anticancer drugs must penetrate tissue efficiently, reaching all target population of cancer cells in a concentration sufficient to exert a therapeutic effect. This study aimed to investigate the ability of methyl-β-cyclodextrin (Me-β-CD) and 2-hydroxypropyl-β-cyclodextrin (Hp-β-CD) to alter the penetration and diffusion of temoporfin (mTHPC) in HT29 multicellular tumor spheroids. mTHPC had а nonhomogenous distribution only on the periphery of spheroids. The presence of β-CDs significantly altered the distribution of mTHPC consisting in the increase of both the depth of photosensitizer penetration and accumulation in HT29 spheroids...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28711386/lipofuscin-generated-by-uva-turns-keratinocytes-photosensitive-to-visible-light
#19
Paulo Newton Tonolli, Orlando Chiarelli-Neto, Carolina Santacruz-Perez, Helena Couto Junqueira, Ii-Sei Watanabe, Felipe Gustavo Ravagnani, Waleska Kerllen Martins, Maurício S Baptista
No abstract text is available yet for this article.
July 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28709920/visual-discomfort-and-flicker
#20
Sanae Yoshimoto, Jesel Garcia, Fang Jiang, Arnold J Wilkins, Tatsuto Takeuchi, Michael A Webster
Flickering lights can be uncomfortable to look at and can induce seizures in observers with photosensitive epilepsy. However, the temporal characteristics contributing to these effects are not fully known. In the spatial domain, one identified source of visual discomfort is when images have Fourier amplitude spectra that deviate from the natural (∼1/frequency, 1/f) statistical characteristics of natural scenes, especially if they contain excess energy at the medium frequencies at which the visual system is most sensitive...
July 11, 2017: Vision Research
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