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https://www.readbyqxmd.com/read/29334586/a-non-heme-iron-photocatalyst-for-light-driven-aerobic-oxidation-of-methanol
#1
Wesley Richard Browne, Juan Chen, Apparao Draksharapu, Maja Gruden, Stepan Stepanovic
The non-heme (L)FeIII and (L)FeIII-O-FeIII(L) complexes (L = 1,1-di(pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)ethan-1-amine) undergoes reduction under irradiation to the FeII state with concomitant oxidation of methanol to methanal, without the need for a secondary photosensitizer. Spectroscopic and Density Functional Theory (DFT) studies support a mechanism in which irradiation results in charge transfer excitation of a FeIII--O-FeIII complex to generate [(L)FeIV=O]2+ (observed transiently during irradiation in acetonitrile), and an equivalent of LFeII...
January 15, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29334184/ph-responsive-peg-doxorubicin-encapsulated-aza-bodipy-nanotheranostic-agent-for-imaging-guided-synergistic-cancer-therapy
#2
Dapeng Chen, Qianyun Tang, Jianhua Zou, Xiaoyan Yang, Wei Huang, Qi Zhang, Jinjun Shao, Xiaochen Dong
Synergistic cancer therapy is of great interest for multiple advantages, such as excellent targeting accuracy, low side effects, and enhanced therapeutic efficiency. Herein, a near-infrared photosensitizer aza-BODIPY (AB) with high singlet oxygen quantum yield (ΦΔ = 82%) is designed and synthesized. With Schiff's base obtained from condensation reaction between doxorubicin (DOX) and polyethylene glycol-benzaldehyde (PEG-CHO) as the polymer matrix, aza-BODIPY is encapsulated to afford hydrophilic nanoparticles (DAB NPs)...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334090/supramolecular-photosensitizers-rejuvenate-photodynamic-therapy
#3
Xingshu Li, Songyi Lee, Juyoung Yoon
Owing to its spatiotemporal selectivity and noninvasive nature, photodynamic therapy (PDT) has become a clinically promising approach for the treatment of a wide range of cancers and other diseases. However, the full potential of PDT has not been achieved thus far as a consequence of the lack of optimal photosensitizers (PSs) and/or smart transport/activation strategies. These problems, which unfortunately lie at the core of the PDT paradigm, include the oxygen reliance limits, the effect of PDT on hypoxic tumors, limitations of light penetration, and undesired skin photosensitization induced by "always on" PSs...
January 15, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29333748/near-infrared-light-sensitive-polyvinyl-alcohol-hydrogel-photoresist-for-spatiotemporal-control-of-cell-instructive-3d-microenvironments
#4
Xiao-Hua Qin, Xiaopu Wang, Markus Rottmar, Bradley J Nelson, Katharina Maniura-Weber
Advanced hydrogel systems that allow precise control of cells and their 3D microenvironments are needed in tissue engineering, disease modeling, and drug screening. Multiphoton lithography (MPL) allows true 3D microfabrication of complex objects, but its biological application requires a cell-compatible hydrogel resist that is sufficiently photosensitive, cell-degradable, and permissive to support 3D cell growth. Here, an extremely photosensitive cell-responsive hydrogel composed of peptide-crosslinked polyvinyl alcohol (PVA) is designed to expand the biological applications of MPL...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333628/re-bpy-co-3cl-immobilized-on-bipyridine-periodic-mesoporous-organosilica-for-photocatalytic-co2-reduction
#5
Minoru Waki, Ken-Ichi Yamanaka, Soichi Shirai, Yoshifumi Maegawa, Yasutomo Goto, Yuri Yamada, Shinji Inagaki
This paper describes the physicochemical properties of a rhenium (Re) complex [Re(bpy)(CO)3Cl] immobilized on a bipyridine-periodic mesoporous organosilica (BPy-PMO) acting as a solid support. The immobilized Re complex generated a metal-to-ligand charge transfer absorption band at 400 nm. This wavelength is longer than that exhibited by Re(bpy)(CO)3Cl in the polar solvent acetonitrile (371 nm) and is almost equal to that in nonpolar toluene (403 nm). The photocatalytic activity of this heterogeneous Re complex was lower than that of a homogeneous Re complex due to the reduced phosphorescence lifetime resulting from immobilization...
January 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29332258/photodynamic-antimicrobial-chemotherapy-pact-using-toluidine-blue-inhibits-both-growth-and-biofilm-formation-by-candida-krusei
#6
Bruna Graziele Marques da Silva, Moisés Lopes Carvalho, Isabela Bueno Rosseti, Stella Zamuner, Maricilia Silva Costa
Among non-albicans Candida species, the opportunistic pathogen Candida krusei emerges because of the high mortality related to infections produced by this yeast. The Candida krusei is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. In spite of the reduced number of infections produced by C. krusei, its occurrence is increasing in some groups of patients submitted to the use of fluconazol for prophylaxis. Photodynamic antimicrobial chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a nontoxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells...
January 13, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29331661/effect-of-laf3-ag-fluorescent-nanoparticles-on-photodynamic-efficiency-and-cytotoxicity-of-protoporphyrin-ix-photosensitizer
#7
F Tavakkoli, M Zahedifar, E Sadeghi
LaF3: Ag nanoparticles (NPs) were synthesized by the co-precipitation method. The produced NPs were characterized by X-ray diffraction (XRD) pattern, scanning electron microscope (SEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FTIR). The emission spectrum of LaF3:Ag NPs is mostly overlapped with the absorption band of protoporphyrin IX (PpIX) and their conjugation was confirmed by studying fluorescence resonance energy transfer (FRET) from LaF3:Ag donor to protoporphyrin IX acceptor...
January 10, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29331487/curecuma-cationic-curcuminoids-with-improved-properties-and-enhanced-antimicrobial-photodynamic-activity
#8
Andreas Spaeth, Andre Graeler, Tim Maisch, Kristjan Plaetzer
The naturally occurring photosensitizer curcumin has excellent biocompatibility, but its antimicrobial photodynamic efficacy is limited by (i) weak adherence to Gram(-) cell walls, (ii) low (photo-)stability and (iii) limited solubility in water. In this study novel curcuminoids bearing cationic substituents were prepared by different synthetic routes. The derivatives exhibit excellent water solubility, improved photostability and low aggregation. All novel curcuminoids showed antibacterial photodynamic effects (>3 log10 reduction of CFU) against Escherichia coli and Staphylococcus aureus upon blue light illumination...
October 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29327917/peptide-based-photoelectrochemical-cytosensor-using-a-hollow-tio2-eg-znin2s4-co-sensitized-structure-for-ultrasensitive-detection-of-early-apoptotic-cells-and-drug-evaluation
#9
Rong Wu, Gao-Chao Fan, Li-Ping Jiang, Jun-Jie Zhu
The ability to rapidly detect apoptotic cells and accurately evaluate therapeutic effects is significant in cancer research. To address this target, a biocompatible, ultrasensitive photoelectrochemical (PEC) cytosensing platform was developed based on electrochemically reduced graphene (EG)/ZnIn2S4 co-sensitized TiO2 coupled with specific recognition between apoptotic cells and phosphatidylserine (PS)-binding peptide (PSBP). In this strategy, HL-60 cells were selected as a model, and C005, nilotinib and imatinib were selected as apoptosis inducers to show cytosensing performance...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29327259/5-aminolevulinic-acid-squalene-nanoassemblies-for-tumor-photodetection-and-therapy-in-vitro-studies
#10
Andrej Babič, V Herceg, E Bastien, H-P Lassalle, L Bezdetnaya, Norbert Lange
Protoporphyrin IX (PpIX) as natural photosensitizer derived from administration of 5-aminolevulinic acid (5-ALA) has found clinical use for photodiagnosis and photodynamic therapy of several cancers. However, broader use of 5-ALA in oncology is hampered by its charge and polarity that result in its reduced capacity for passing biological barriers and reaching the tumor tissue. Advanced drug delivery platforms are needed to improve the biodistribution of 5-ALA. Here, we report a new approach for the delivery of 5-ALA...
January 11, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29325823/photo-geno-toxicity-changes-associated-with-hydroxylation-of-the-aromatic-chromophores-during-diclofenac-metabolism
#11
Guillermo Garcia-Lainez, Ana M Martínez-Reig, Daniel Limones-Herrero, M Consuelo Jiménez, Miguel A Miranda, Inmaculada Andreu
Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order to avoid these side effects. However, previous studies have shown that DCF, in combination with sunlight, displays capability to induce photosensitivity disorders. In humans, DCF is biotransformed into hydroxylated metabolites at positions 4' and 5 (4'OH-DCF and 5OH-DCF), and this chemical change produces non negligible alterations of the drug chromophore, resulting in a significant modification of its light-absorbing properties...
January 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29323883/a-stable-blue-photosensitizer-for-color-palette-of-dye-sensitized-solar-cells-reaching-12-6-efficiency
#12
Yameng Ren, Danyang Sun, Yiming祎明 Cao曹, Hoi Nok Tsao, Yi Yuan, Shaik M Zakeeruddin, Peng Wang, Michael Grätzel
We report a blue donor-acceptor organic dye, coded as R6, which features a primary chromophore of a polycyclic aromatic hydrocarbon 9,19-dihydrobenzo[1',10']phenanthro[3',4':4,5]thieno[3,2-b]benzo[1,10]phenanthro[3,4-d]thiophene (BPT2) coupled with a diarylamine electron-donor and 4-(7-ethynylbenzo[c][1,2,5]thiadiazol-4-yl)benzoic acid acceptor. Dye R6 displays a brilliant sapphire color on a sensitized titania mesoporous film together with a Co(II/III)tris(bipyridyl)-based redox electrolyte. Significantly, such judiciously tailored DSCs achieve an impressive solar-to-electric power conversion efficiency (PCE) of 12...
January 11, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29323875/theranostics-of-triple-negative-breast-cancer-based-on-conjugated-polymer-nanoparticles
#13
Guorui Jin, Rongyan He, Qian Liu, Yuqing Dong, Min Lin, Wenfang Li, Feng Xu
Triple negative breast cancer (TNBC) does not respond to many targeted drugs due to the lack of three receptors (i.e., estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2), which makes it difficult for TNBC detection and treatment. As compared to traditional breast cancer treatments such as surgery and chemotherapy, photodynamic therapy (PDT) has emerged as a promising approach for treating TNBC due to its precise controllability, high spatiotemporal accuracy and minimal invasive nature...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29323251/vitamin-e-inhibits-the-uvai-induction-of-light-and-dark-cyclobutane-pyrimidine-dimers-and-oxidatively-generated-dna-damage-in-keratinocytes
#14
George J Delinasios, Mahsa Karbaschi, Marcus S Cooke, Antony R Young
Solar ultraviolet radiation (UVR)-induced DNA damage has acute, and long-term adverse effects in the skin. This damage arises directly by absorption of UVR, and indirectly via photosensitization reactions. The aim of the present study was to assess the effects of vitamin E on UVAI-induced DNA damage in keratinocytes in vitro. Incubation with vitamin E before UVAI exposure decreased the formation of oxidized purines (with a decrease in intracellular oxidizing species), and cyclobutane pyrimidine dimers (CPD)...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322569/a-copper-ii-molecular-catalyst-for-efficiently-and-selectively-photochemical-reduction-of-co2-to-co-in-a-water-containing-system
#15
Di-Chang Zhong, Wen-Ju Liu, Hai-Hua Huang, Ting Ouyang, Long Jiang, Wen Zhang, Tong-Bu Lu
A catalyst developed from a Cu(II) complex of (Et4N)[Cu(pyN2Me2)(HCO2)]∙0.5CH3OH∙H2O (1∙0.5CH3OH∙H2O; pyN2Me2 = bis(2,6-dimethylphenyl)-2,6-pyridinedicarboxamidate(2-)) shows a high activity to catalyze the reduction reaction of CO2 to CO driven by visible light in 4:1 acetonitrile/water (v:v) using [Ru(phen)3](PF6)2 as photosensitizer and TEOA as sacrificial reductant, with a high TON of 9900 and a high selectivity of 98%. The results of isotope labeling experiment, durable test and energy dispersive spectroscopy reveal that 1 is robust during the photocatalytic process...
January 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29320498/molecular-mapping-of-qtl-alleles-of-brassica-oleracea-affecting-days-to-flowering-and-photosensitivity-in-spring-brassica-napus
#16
Habibur Rahman, Rick A Bennett, Berisso Kebede
Earliness of flowering and maturity are important traits in spring Brassica napus canola-whether grown under long- or short-day condition. By use of a spring B. napus mapping population carrying the genome content of B. oleracea and testing this population under 10 to 18 h photoperiod and 18 to 20 0C (day) temperature conditions, we identified a major QTL on the chromosome C1 affecting flowering time without being influenced by photoperiod and temperature, and a major QTL on C9 affecting flowering time under a short photoperiod (10 h); in both cases, the QTL alleles reducing the number of days to flowering in B...
2018: PloS One
https://www.readbyqxmd.com/read/29319791/doxycycline-photosensitivity
#17
A Randhawa, I Ngu, D Bilsland
No abstract text is available yet for this article.
January 8, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29319078/excitation-energies-singlet-triplet-energy-gaps-spin-orbit-matrix-elements-and-heavy-atom-effects-in-boimpys-as-possible-photosensitizers-for-photodynamic-therapy-a-computational-investigation
#18
Bruna Clara De Simone, Gloria Mazzone, Nino Russo, Emilia Sicilia, Marirosa Toscano
Bis(borondifluoride)-8-imidazodipyrromethene (BOIMPY) based molecules show interesting photophysical properties. We have undertaken a computational study at DFT and TDDFT levels of theory with the aim of verifying if the non-fluorescent BOIMPYs meet those properties necessary to be proposed as potential photosensitizers for photodynamic therapy (PDT). In particular, we have computed the absorption wavelengths, the singlet-triplet energy gaps and the spin-orbit matrix elements. The effect of halogen atom substitution (Br, I), in different amounts and positions in the BOIMPY skeleton, on the photophysical properties, has been elucidated...
January 10, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29318776/highly-luminescent-and-water-soluble-two-dimensional-supramolecular-organic-framework-all-organic-photosensitizer-template-for-visible-light-driven-hydrogen-evolution-from-water
#19
Hyun-Jun Lee, Hyeong-Ju Kim, Eung-Chang Lee, Jaekwan Kim, Soo Young Park
A highly fluorescent (ΦF = 0.60) and water-soluble two-dimensional (2D) honeycomb-shaped supramolecular organic framework (SOF) was successfully synthesized in pure aqueous solution via self-assembly of novel cyanostilbene-functionalized trilateral guest molecules and cucurbit[8]uril hosts. Size of this fluorescent 2D SOF was over 500 nm in diameter, 1.7 nm in thickness, and 3.9 nm in the honeycomb pore diameter. This 2D SOF showed a promising potential as a new all-organic photosensitizer template for photocatalytic H₂ evolution from pure water...
January 10, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29318236/selective-visible-light-driven-oxygen-reduction-to-hydrogen-peroxide-using-bodipy-photosensitizers
#20
Xiaojun Guo, Xialiang Li, Xiao-Chen Liu, Ping Li, Zhen Yao, Jianfeng Li, Wei Zhang, Jian-Ping Zhang, Dong Xue, Rui Cao
Selective visible-light-driven O2 reduction to H2O2 was realized using BODIPY photosensitizers (PS) in the presence of ferrocene (Fc) as the reductant and acetic acid as the proton source. Mechanistic studies suggested that O2 could be activated by 3PS* through an energy transfer pathway to give singlet oxygen (1O2) in the absence of Fc. However, with Fc, 3PS* was first reductively quenched to PS˙-, which was able to reduce O2 to the superoxide radical form in a subsequent electron transfer step.
January 10, 2018: Chemical Communications: Chem Comm
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