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https://www.readbyqxmd.com/read/28247741/-a-systematic-review-and-meta-analysis-to-assess-the-recurrence-free-survival-in-non-muscle-invasive-bladder-cancer-after-transurethral-resection-guided-by-5-aminolevulinic-acid-induced-photodynamic-diagnosis-compared-with-white-light-transurethral-resect
#1
A I Rolevich, A A Evmenenko
INTRODUCTION: We conducted a meta-analysis assessing the effect of photodynamic diagnosis (PDD) -guided transurethral resection of the bladder tumor (TURB) on the recurrence-free survival in patients with non-muscle invasive bladder cancer within prospective randomised trials that used 5-aminolevulinic acid as a photosensitizer. MATHERIAL AND METHODS: Medical literature search was performed up to February 2016. Recurrence hazard ratios (HRs) and its 95% confidence intervals (CI) were calculated for each selected study with direct and indirect methods and the pooled estimates were obtained with random-effects model...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28245479/potential-utility-of-diffusion-weighted-magnetic-resonance-imaging-in-diagnosis-of-residual-bladder-cancer-before-second-transurethral-resection
#2
Yuki Nakamura, Soichiro Yoshida, Hiroshi Tanaka, Masaharu Inoue, Masaya Ito, Toshiki Kijima, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii, Kazunori Kihara
INTRODUCTION: The study aimed to investigate the diagnostic utility of diffusion-weighted MRI (DW-MRI) in differentiating residual bladder cancer from benign postoperative changes before a second transurethral resection of the bladder (TURB). MATERIALS AND METHODS: Of the 75 bladder cancer patients who underwent a second TURB from 2013 to 2015, 23 patients who underwent multi-sequence bladder MRI after their initial TURB were retrospectively evaluated. Thirty lesions were histologically examined at the second TURB and the results of them were compared with the findings obtained through T2-weighted MRI, dynamic contrast-enhanced MRI (DCE-MRI), and DW-MRI...
March 1, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28188046/the-prognostic-role-of-circulating-tumor-cells-ctc-in-high-risk-non-muscle-invasive-bladder-cancer
#3
Gian Maria Busetto, Matteo Ferro, Francesco Del Giudice, Gabriele Antonini, Benjamin I Chung, Isabella Sperduti, Diana Giannarelli, Giuseppe Lucarelli, Marco Borghesi, Gennaro Musi, Ottavio de Cobelli, Ettore De Berardinis
INTRODUCTION: The purpose of this study was to evaluate the impact of circulating tumor cells (CTCs) as a prognostic marker in patients with high-risk non-muscle-invasive bladder cancer (NMIBC) and assess the efficacy and reliability of 2 different CTC isolation methods. MATERIALS AND METHODS: Globally, 155 patients with a pathologically confirmed diagnosis of high-risk NMIBC were included (pT1G3 with or without carcinoma in situ) and underwent transurethral resection of bladder tumor (TURB) after a blood withdrawal for CTC evaluation...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28050795/how-different-cystoscopy-methods-influence-patient-sexual-satisfaction-anxiety-and-depression-levels-a-randomized-prospective-trial
#4
Wojciech Krajewski, Katarzyna Kościelska-Kasprzak, Joanna Rymaszewska, Romuald Zdrojowy
PURPOSE: Bladder cancer (BC) is one of the most common cancers worldwide. BC diagnosis and surveillance is based on cystoscopy (CS). CS impact on patient's depression, anxiety, and sexual satisfaction (SS) is not sufficiently studied. There are no data on patient's comfort with flexible or rigid CS. METHODS: We prospectively evaluated pain perception (PP), depression, anxiety, and SS of 100 male patients who previously underwent at least one rigid CS in our department as surveillance after TURB procedure due to non-muscle-invasive BC and were scheduled for the next CS examination...
March 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28039452/preoperative-neutrophil-lymphocyte-ratio-can-significantly-predict-mortality-outcomes-in-patients-with-non-muscle-invasive-bladder-cancer-undergoing-transurethral-resection-of-bladder-tumor
#5
Minyong Kang, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
The prognostic role of systemic inflammatory response (SIR) markers is unclear in patients with non-muscle invasive bladder cancer (NMIBC). Here, we aimed to investigate the prognostic role of various SIR markers in the oncological outcomes in non-muscle invasive bladder cancer (NMIBC) patients at a single institution in Korea. Neutrophil-lymphocyte ratio (NLR), derived-NLR (dNLR), and platelet-lymphocyte ratio (PLR) were examined as SIR markers. We retrospectively collected data of 1,698 NMIBC patients who underwent transurethral resection of the bladder (TURB) between 1990 and 2013...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27941379/can-we-improve-transurethral-resection-of-the-bladder-tumour-for-nonmuscle-invasive-bladder-cancer
#6
Esmee Iml Liem, Theo M de Reijke
PURPOSE OF REVIEW: The recurrence rate in patients with nonmuscle invasive bladder cancer is high, and the quality of transurethral resection of the bladder (TURB) tumour influences recurrence risk. We review new methods that aim to improve the effectiveness of TURB, and highlight studies of the past year. RECENT FINDINGS: Several approaches have been explored: bipolar resection is well tolerated and efficient; however, surgical outcomes are not clearly superior to monopolar resection; en-bloc resection seems feasible and well tolerated, and has the potential to improve the quality of tissue for histopathology; enhancement techniques such as photodynamic diagnosis, narrow band imaging, and Image1 S improve tumour detection, whereas photodynamic diagnosis reduces recurrence rates; high-resolution imaging modality such as confocal laser endomicroscopy may provide histopathologic information...
March 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/27908681/preoperative-anemia-is-associated-with-disease-recurrence-and-progression-in-patients-with-non-muscle-invasive-bladder-cancer
#7
Francesco Soria, Marco Moschini, Mohammad Abufaraj, Gregory J Wirth, Beat Foerster, Kilian M Gust, Mehmet Özsoy, Alberto Briganti, Paolo Gontero, Romain Mathieu, Morgan Rouprêt, Pierre I Karakiewicz, Shahrokh F Shariat
PURPOSE: To evaluate the effect of preoperative anemia (PA) on oncological outcomes in a multicenter cohort of patients with non-muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of the bladder (TURB) and adjuvant intravesical therapies. We hypothesize that PA represents a marker of disease aggressiveness and could be used to improve the discrimination of prognostic tools for the prediction of disease recurrence and progression. METHODS: This multicenter retrospective study included 1,117 patients from 4 different centers...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/27899955/comparison-between-standard-and-reduced-volume-radiotherapy-in-bladder-preservation-trimodality-protocol-for-muscle-invasive-bladder-cancer-patients
#8
Waleed Arafat, Azza Darwish, George E Naoum, Wael Sameh, Gamal El Husseiny, Fathy Abd-El-Gawad, Mostafa Samir
AIM: Our aim is to compare the toxicity, pelvic nodal relapse, and overall survival of whole bladder irradiation only to the standard technique of whole pelvis irradiation followed by bladder boost in patients with muscle-invasive bladder carcinoma undergoing bladder preservation protocol. MATERIAL AND METHOD: A total of 60 patients with transitional cell carcinoma, stage T2-3, N0, M0 bladder cancer were subjected to maximal transurethral resection bladder tumour (TURB)...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27765044/bladder-chondrosarcoma-plus-urothelial-carcinoma-in-recurred-transitional-cell-carcinoma-of-the-upper-urinary-tract-a-case-report-and-literature-review
#9
Min Hyun Cho, Sung Han Kim, Weon Seo Park, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Kang Hyun Lee
BACKGROUND: Sarcomatoid urothelial carcinoma (SUC) is a rare malignant neoplasm of the urinary bladder comprising 0.2-0.6 % of all histological bladder tumor subtypes. It presents as a high-stage malignancy and exhibits aggressive biological behavior, regardless of the treatment employed. It is defined as histologically indistinguishable from sarcoma and as a high-grade biphasic neoplasm with malignant epithelial and mesenchymal components. The mean age of patients presenting with SUC is 66 years, and the male-to-female ratio is 3:1...
October 20, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27712914/-intravesical-instillations-in-non-muscle-invasive-bladder-cancer-nmibc-prospects-for-thermochemotherapy
#10
J Irani
Non-muscle-invasive bladder cancer (NMIBC) is characterised by a high risk of recurrence when performing only a transurethral resection of the bladder (TURB). Intravesical instillations are performed postoperatively to decrease the rate of recurrence. The standard agents currently used are Mitomycin-C (MMC) or bacillus Calmette-Guérin (BCG). In order to further enhance the efficacy of the adjuvant treatments and/or diminish their side effects, alternative treatments are studied. Intravesical MMC combined with hyperthermia could be an interesting alternative active treatment for intermediate- and possibly high-risk NMIBC, and has been investigated in the past years...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27578233/optimised-photodynamic-diagnosis-for-transurethral-resection-of-the-bladder-turb-in-german-clinical-practice-results-of-the-noninterventional-study-optic-iii
#11
Thorsten Bach, Patrick J Bastian, Andreas Blana, Angelika Kaminsky, Stefan Keller, Thomas Knoll, Christoph Lang, Soeren Promnitz, Burkhard Ubrig, Thomas Keller, Bryan Qvick, Maximilian Burger
PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use...
August 30, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27564278/neutrophil-to-lymphocyte-ratio-a-biomarker-in-non-muscle-invasive-bladder-cancer-a-single-institutional-longitudinal-study
#12
Vincenzo Favilla, Tommaso Castelli, Daniele Urzì, Giulio Reale, Salvatore Privitera, Antonio Salici, Giorgio Ivan Russo, Sebastiano Cimino, Giuseppe Morgia
BACKGROUND: Bladder cancer represents one of the most important clinical challenges in urologic practice. In this context, inflammation has an important role in the development and progression of many malignancies. The objective of the present study was to evaluate the prognostic value of pre-treatment Neutrophil to lymphocyte ratio (NLR) on the risk of recurrence and progression in patients with primary non-muscle invasive bladder cancer. MATERIALS AND METHODS: Data obtained from 178 bladder cancer patients who underwent transurethral resection of bladder tumor (TURB) between July 2008 and December 2014 were evaluated prospectively...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27458489/patient-comfort-during-flexible-and-rigid-cystourethroscopy
#13
Wojciech Krajewski, Romuald Zdrojowy, Joanna Wojciechowska, Katarzyna Kościelska, Janusz Dembowski, Michał Matuszewski, Krzysztof Tupikowski, Bartosz Małkiewicz, Anna Kołodziej
INTRODUCTION: Cystourethroscopy (CS) is an endoscopic method used to visualize the urethra and the bladder. AIM: In this study, we prospectively evaluated pain in men undergoing cyclic cystoscopic assessment with rigid and flexible instruments after transurethral resection of bladder tumor (TURB). MATERIAL AND METHODS: One hundred and twenty male patients who were under surveillance after a TURB procedure due to urothelial cell carcinoma and who had undergone at least one rigid cystourethroscopy in the past were enrolled in the trial...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27381893/replacing-cystoscopy-by-urine-markers-in-the-follow-up-of-patients-with-low-risk-non-muscle-invasive-bladder-cancer-an-international-bladder-cancer-network-project
#14
REVIEW
Claudia Schmitz-Dräger, Nadine Bonberg, Beate Pesch, Tilman Todenhöfer, Sevim Sahin, Thomas Behrens, Thomas Brüning, Bernd J Schmitz-Dräger
RATIONALE: Numerous molecular urine markers for the diagnosis of bladder cancer have been developed and evaluated mostly in case-control settings through the past decades. However, despite all efforts none of them has been included into clinical decision-making and guideline recommendations until today. The aim of this retrospective longitudinal analysis was to investigate if a molecular marker might be able to replace cystoscopy as a primary examination in diagnosis and follow-up of patients with pTa grade 1-2 bladder cancer...
October 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27377079/prognostic-impact-of-returb-in-high-grade-t1-primary-bladder-cancer
#15
Roberto Sanseverino, Giorgio Napodano, Antonio Campitelli, Maria Addesso
PURPOSE: To evaluate whether pathological outcomes of ReTURB have a prognostic impact on recurrence and progression of primitive T1HG bladder cancer. MATERIAL AND METHODS: Patients affected by primitive T1HG TCC of bladder underwent restaging TURB (ReTURB). Patients with muscle invasive disease at ReTURB underwent radical cystectomy; those with non-muscle invasive residual (NMI-RT) and those with no residual tumour (NRT) received an intravesical BCG therapy. We compared recurrence and progression in NMIRT patients and NRT patients at restaging TURB...
July 4, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27324428/eau-guidelines-on-non-muscle-invasive-urothelial-carcinoma-of-the-bladder-update-2016
#16
Marko Babjuk, Andreas Böhle, Maximilian Burger, Otakar Capoun, Daniel Cohen, Eva M Compérat, Virginia Hernández, Eero Kaasinen, Joan Palou, Morgan Rouprêt, Bas W G van Rhijn, Shahrokh F Shariat, Viktor Soukup, Richard J Sylvester, Richard Zigeuner
CONTEXT: The European Association of Urology (EAU) panel on Non-muscle-invasive Bladder Cancer (NMIBC) released an updated version of the guidelines on Non-muscle-invasive Bladder Cancer. OBJECTIVE: To present the 2016 EAU guidelines on NMIBC. EVIDENCE ACQUISITION: A broad and comprehensive scoping exercise covering all areas of the NMIBC guidelines published between April 1, 2014, and May 31, 2015, was performed. Databases covered by the search included Medline, Embase, and the Cochrane Libraries...
March 2017: European Urology
https://www.readbyqxmd.com/read/27323781/single-immediate-postoperative-instillation-of-chemotherapy-in-non-muscle-invasive-bladder-cancer-a-systematic-review-and-network-meta-analysis-of-randomized-clinical-trials-using-different-drugs
#17
Minyong Kang, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
We performed a network meta-analysis of randomized controlled trials (RCTs) to compare the efficacy of several intravesical chemotherapeutic (IVC) agents after transurethral resection of bladder tumor (TURB) in non-muscle invasive bladder cancer patients. The literature search was conducted using the Embase, Scopus and PubMed databases for RCTs, including patients with single or multiple, primary or recurrent stage Ta or T1 urothelial carcinoma of the bladder managed with a single, immediate instillation of IVC after TURB...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27316373/development-of-a-preoperative-nomogram-incorporating-biomarkers-of-systemic-inflammatory-response-to-predict-nonorgan-confined-urothelial-carcinoma-of-the-bladder-at-radical-cystectomy
#18
Ilaria Lucca, Sebastian L Hofbauer, Carmen V Leitner, Michela de Martino, Mehmet Özsoy, Martin Susani, Shahrokh F Shariat, Tobias Klatte
OBJECTIVE: To develop a preoperative multivariable decision-making tool to predict nonorgan-confined urothelial carcinoma of the bladder (NOC-UCB) using standard clinical and pathological factors as well as biomarkers of systemic inflammatory response. MATERIALS AND METHODS: We retrospectively analyzed a prospectively maintained single-institutional database comprising 310 patients with clinically N0 M0 UCB who underwent radical cystectomy (RC) with pelvic lymph node dissection without neoadjuvant cisplatin-based chemotherapy (NAC)...
September 2016: Urology
https://www.readbyqxmd.com/read/27106005/can-immediate-second-resection-be-an-alternative-to-standardized-second-transurethral-resection-of-bladder-tumors
#19
Engin Doğantekin, Cengiz Girgin, Sacit Nuri Görgel, Haluk Soylemez, Çetin Dinçel
This study analyzed the impact of an immediate second transurethral resection of bladder tumor (TURBT) protocol on residual tumor status at the initial TURBT session and the recurrence rate in the primary resection area. We prospectively evaluated and randomized 47 consecutive patients who underwent TURBT sessions for bladder cancer. In accordance with the inclusion criteria, of the 47 consecutive patients, 19 (Group I) underwent immediate second resection of the tumor bed after complete TUR and 28 (Group II) did not...
March 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27097964/anti-inflammatory-effects-exerted-by-killox%C3%A2-an-innovative-formulation-of-food-supplement-with-curcumin-in-urology
#20
V Cosentino, A Fratter, M Cosentino
OBJECTIVE: In this Open Controlled Trial we administered an innovative formulation of food supplement with curcumin (Killox®) to test its efficacy, safety and compatibility with other drugs, in the therapy of post-surgery complications of transurethral resection of prostate (TURP) and transurethral resection of bladder (TURB), and in the prevention of late complications. Furthermore, Killox® effects were verified in subjects with benign prostatic hyperplasia (BPH). PATIENTS AND METHODS: Killox® was administered to 40 TURP patients for 20 days, to 10 TURB patients for 10 days and to 30 BPH patients for 60 days...
April 2016: European Review for Medical and Pharmacological Sciences
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