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JOURNAL ARTICLE
Chand Bibi, Zar Nigar
INTRODUCTION: Ageing is a natural process of life. With increasing age, the skin suffers progressive morphological and physiological decrement. Hyperpigmentation, Wrinkles, and roughness of skin are some of the symptoms of aged skin. Exposure to sunlight, pollution, stress, nicotine, etc aggravates Skin aging. This study aimed to determine the efficacy and safety of polyherbal formulation and compare its efficacy with the standard drug tretinoin in subjects of moderate to advanced Photoaged facial skin...
March 22, 2024: Alternative Therapies in Health and Medicine
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JOURNAL ARTICLE
Clément Klein, Serge Brunelle, Mathias Illy, Valeria De Luca, Laure Doisy, François Lannes, Davidson Sypre, Nicolas Branger, Thomas Maubon, Stanislas Rybikowski, Mathilde Guérin, Gwenaëlle Gravis, Jochen Walz, Geraldine Pignot
PURPOSE: The standard follow-up for non-muscle-invasive bladder cancer is based on cystoscopy. Unfortunately, post-instillation inflammatory changes can make the interpretation of this exam difficult, with lower specificity. This study aimed to evaluate the interest of bladder MRI in the follow-up of patients following intravesical instillation. METHODS: Data from patients who underwent cystoscopy and bladder MRI in a post-intravesical instillation setting between February 2020 and March 2023 were retrospectively collected...
March 20, 2024: World Journal of Urology
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JOURNAL ARTICLE
Clinton W F Rissmann, Lisa K Pearson, Ton H Snelder
Spatial variation in the landscape factors climate, geomorphology, and lithology cause significant differences in water quality issues even when land use pressures are similar. The Physiographic Environment Classification (PEC) classifies landscapes based on their susceptibility to the loss of water quality contaminants. The classification is informed by a conceptual model of the landscape factors that control the hydrochemical maturity of water discharged to streams. In New Zealand, a case study using climatic, topographic, and geological data classified the country into six, 36, and 320 classes at Levels 1 (Climate), 1-2 (Climate + Geomorphology), and 1-3 (Climate + Geomorphology + Lithology), respectively...
March 5, 2024: Environmental Management
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JOURNAL ARTICLE
Juliusz J Szczesniewski, Magaly T Márquez-Sánchez, Bárbara Padilla-Fernández, Luis Llanes-González, María F Lorenzo-Gómez
PURPOSE: Bacteriuria may affect the response to adjuvant therapy in non-muscle invasive bladder cancer (NMIBC). The main aim of this study was to examine the effect of recurrent bacteriuria (RB) on the prognosis of NMIBC in women receiving intravesical therapy. MATERIALS AND METHODS: We designed a prospective observational study from 2012 to 2019. We included women with bladder cancer treated with transurethral resection of the bladder (TURB) and adjuvant intravesical treatment...
February 1, 2024: Clinical Genitourinary Cancer
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JOURNAL ARTICLE
Ahmed M El-Feky, Mohamed Saber, Mahmoud M Abd-El-Kader, Sameh A Kantoush, Tetsuya Sumi, Faisal Alfaisal, Amal Abdelhaleem
The presence of a wastewater treatment plant in the Arab El-Madabegh region, which discharges excessive amounts of raw effluent toward the nearby farming fields, is the area's main issue. Examining the harmful implications of raw effluent releases on groundwater quality, determining if treated wastewater effluent complies with regulations for discharge into the aquatic environment, and assessing irrigation appropriateness by the effluent are the main goals of this work. In order to accomplish these targets, twelve treated effluent samples from the Arab El-Madabegh wastewater treatment plant were gathered every two weeks starting in January 2012 and finishing in June 2012...
2024: PloS One
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JOURNAL ARTICLE
Colin Bredenberg, Cristina Savin, Roozbeh Kiani
Technical advances in artificial manipulation of neural activity have precipitated a surge in studying the causal contribution of brain circuits to cognition and behavior. However, complexities of neural circuits challenge interpretation of experimental results, necessitating new theoretical frameworks for reasoning about causal effects. Here, we take a step in this direction, through the lens of recurrent neural networks trained to perform perceptual decisions. We show that understanding the dynamical system structure that underlies network solutions provides a precise account for the magnitude of behavioral effects due to perturbations...
February 27, 2024: Journal of Neuroscience
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JOURNAL ARTICLE
Jonathan D Santoro, Jason J Sico, James F Burke, Korak Sarkar, Madeline Turbes, David A Evans, Justin T Jordan
This position statement serves to establish the AAN's stance on the methods to address the cost of prescription drugs being considered by state and federal policymakers so that the AAN can continue to advocate effectively for its members. Neurologists seek to provide high-value care for patients with neurologic diseases at the lowest cost possible. However, many therapies for neurologic diseases are among the most expensive in the United States. The 3 major cost challenges include (1) unjustified increases in the pricing for drugs used to treat neurologic disorders, (2) the high cost of medications used to treat rare diseases where there are limited or no therapeutic options available, and (3) the high cost of noninnovative (already FDA-approved) therapies that used accelerated FDA approval pathways or Orphan Drug Act designated to expedite approvals in neurologic disorders...
March 12, 2024: Neurology
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Periklis Anastasiou, Napoleon Moulavasilis, Konstantinos Douroumis, Panagiotis Katsikatsos, Dionisios Mitropoulos, Ioannis Anastasiou
Angiomyxoma is a rare mesenchymal tumor arising in the pelvic and perineal regions. Diagnosis of urinary bladder angiomyxoma is difficult, as it lacks typical signs and symptoms, and relies on immunochemistry. We present the case of a 53 year old patient presenting with an incidental finding of bladder tumor during an ultrasound. After a complete transurethral resection was performed, the pathology report led to angiomyxoma diagnosis. After 6 weeks a secondary TURB, along with a CT urogram showed no evidence of residual volume...
March 2024: Urology Case Reports
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JOURNAL ARTICLE
Amal Ben Ayed, Imen Akrout, Karima Staita, Quentin Albert, Stéphane Greff, Charlotte Simmler, Steven Ahrendt, Kurt LaButti, Anna Lipzen, Guifen He, Emily Savage, Jean Armengaud, Mélodie Kielbasa, David Navarro, Elodie Drula, Annick Turbé-Doan, Emmanuel Bertrand, Anne Lomascolo, Delphine Chaduli, Craig B Faulds, Mohamed Chamkha, Amina Maalej, Kerrie Barry, Igor V Grigoriev, Francis Martin, Héla Zouari-Mechichi, Giuliano Sciara, Tahar Mechichi, Eric Record
Despite various plans to rationalize antibiotic use, antibiotic resistance in environmental bacteria is increasing due to the accumulation of antibiotic residues in the environment. This study aimed to test the ability of basidiomycete fungal strains to biotransform the antibiotic levofloxacin, a widely-used third-generation broad-spectrum fluoroquinolone, and to propose enzyme targets potentially involved in this biotransformation. The biotransformation process was performed using fungal strains. Levofloxacin biotransformation reached 100% after 9 days of culture with Porostereum spadiceum BS34...
January 9, 2024: Ecotoxicology and Environmental Safety
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JOURNAL ARTICLE
Donal Bisanzio, Robert Butcher, Valérian Turbé, Kenji Matsumoto, Chaitra Dinesh, Patrick Massae, Michael Dejene, Cristina Jimenez, Colin Macleod, Einoti Matayan, Caleb Mpyet, Alex Pavluck, Martha Idalí Saboyá-Díaz, Fentahun Tadesse, Sandra Liliana Talero, Anthony W Solomon, Jeremiah Ngondi, George Kabona, Cecilia Uisso, Alistidia Simon, Upendo Mwingira, Emma M Harding-Esch
BACKGROUND: Photography could be used to train individuals to diagnose trachomatous inflammation-follicular (TF) as trachoma prevalence decreases and to ensure accurate field TF grading in trachoma prevalence surveys. We compared photograph and field TF grading and determined the acceptability and feasibility of eyelid photography to community members and trachoma survey trainers. METHODS: A total of 100 children ages 1-9 y were examined for TF in two Maasai villages in Tanzania...
December 23, 2023: International Health
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JOURNAL ARTICLE
Lukas Scheipner, Hanna Zurl, Julia V Altziebler, Georg P Pichler, Stephanie Schöpfer-Schwab, Samra Jasarevic, Michael Gaisl, Klara C Pohl, Karl Pemberger, Stefan Andlar, Georg C Hutterer, Uros Bele, Conrad Leitsmann, Marianne Leitsmann, Herbert Augustin, Richard Zigeuner, Sascha Ahyai, Johannes Mischinger
PURPOSE: To test the association between the Charlson-Deyo Comorbidity Index (CCI) and the recurrence of non-muscle-invasive bladder cancer (NMIBC). METHODS: NMIBC (Ta, T1, TIS) patients who underwent transurethral resection of bladder tumor (TURB) between 2010 and 2018 were identified within a retrospective data repository of a large university hospital. Kaplan-Meier estimates and uni- and multivariable Cox regression models tested for differences in risk of recurrence according to low vs...
December 8, 2023: Cancers
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JOURNAL ARTICLE
Clément Dondé, Nathalie Coulon, Hugo Turbé, Myrtille Andre, Laurent Boyer, Delphine Capdevielle, Isabelle Chereau, Romane Dassing, Jean-Michel Dorey, Caroline Dubertret, Sylvain Leignier, Pierre-Michel Llorca, David Misdrahi, Christine Passerieux, Baptiste Pignon, Romain Rey, Benoît Schorr, Franck Schürhoff, Mathieu Urbach, Guillaume Fond, Jasmina Mallet
BACKGROUND: Childhood Attention-deficit/hyperactivity disorder (C-ADHD) is a neurodevelopmental disorder, associated with an increased risk of subsequent schizophrenia. The objective of the present study was to determine the prevalence of C-ADHD in schizophrenia and the clinical and cognitive characteristics associated with C-ADHD history in schizophrenia. METHODS: 569 subjects with schizophrenia (74 % men, mean age 30.8) were included in ten expert centers at a national level and tested with a comprehensive battery of clinician-rated, patient-reported scales and cognitive tests...
December 19, 2023: Schizophrenia Research
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JOURNAL ARTICLE
Irene J Beijert, Anouk E Hentschel, Johannes Bründl, Eva M Compérat, Karin Plass, Oscar Rodríguez, Jose D Subiela Henríquez, Virginia Hernández, Enrique de la Peña, Isabel Alemany, Diana Turturica, Francesca Pisano, Francesco Soria, Otakar Čapoun, Lenka Bauerová, Michael Pešl, H Maxim Bruins, Willemien Runneboom, Sonja Herdegen, Johannes Breyer, Antonin Brisuda, Ana Calatrava, José Rubio-Briones, Maximilian Seles, Sebastian Mannweiler, Judith Bosschieter, Venkata R M Kusuma, David Ashabere, Nicolai Huebner, Juliette Cotte, Roberto Contieri, Laura S Mertens, Francesco Claps, Alexandra Masson-Lecomte, Fredrik Liedberg, Daniel Cohen, Luca Lunelli, Olivier Cussenot, Soha El Sheikh, Dimitrios Volanis, Jean-François Côté, Morgan Rouprêt, Andrea Haitel, Shahrokh F Shariat, A Hugh Mostafid, Jakko A Nieuwenhuijzen, Richard Zigeuner, Jose L Dominguez-Escrig, Jaromir Hacek, Alexandre R Zlotta, Maximilian Burger, Matthias Evert, Christina A Hulsbergen-van de Kaa, Antoine G van der Heijden, Lambertus A L M Kiemeney, Viktor Soukup, Luca Molinaro, Paolo Gontero, Carlos Llorente, Ferran Algaba, Joan Palou, James N'Dow, Maria J Ribal, Theo H van der Kwast, Marko Babjuk, Richard J Sylvester, Bas W G van Rhijn
PURPOSE: A re-transurethral resection of the bladder (re-TURB) is a well-established approach in managing non-muscle invasive bladder cancer (NMIBC) for various reasons: repeat-TURB is recommended for a macroscopically incomplete initial resection, restaging-TURB is required if the first resection was macroscopically complete but contained no detrusor muscle (DM) and second-TURB is advised for all completely resected T1-tumors with DM in the resection specimen. This study assessed the long-term outcomes after repeat-, second-, and restaging-TURB in T1-NMIBC patients...
November 19, 2023: International Urology and Nephrology
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JOURNAL ARTICLE
Q Arnaud, P Sebe, A Colau, M Mouton, F Desgrandchamps, A Masson-Lecomte, T Bessede, J Irani, I Dominique
PURPOSE: Performing restaging transurethral bladder resection (reTURB) for high-risk non-muscle invasive bladder cancer (NMIBC) reduces the risk of recurrence and tumour understaging. Management of residual high-grade papillary Ta or T1 after reTURB has changed this last 10years in international recommendations. This study aimed to compare the recurrence free survival according to the different management procedures performed. MATERIALS AND METHODS: Patients who underwent reTURB for initial high-risk NMIBC between 2011 and 2020 were included...
November 16, 2023: Progrès en Urologie
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JOURNAL ARTICLE
Kang Liu, Hongda Zhao, Xuan Chen, Rossella Nicoletti, Nikhil Vasdev, Peter Ka-Fung Chiu, Chi-Fai Ng, Tatsushi Kawada, Ekaterina Laukhtina, Keiichiro Mori, Takafumi Yanagisawa, David D'Andrea, Markus von Deimling, Simone Albisinni, Wojciech Krajewski, Benjamin Pradere, Francesco Soria, Marco Moschini, Dmitry Enikeev, Shahrokh Shariat, Ashish Kamat, Gianluca Giannarini, Jeremy Yuen-Chun Teoh
BACKGROUND: Current European Association of Urology (EAU) guidelines support adjuvant intravesical Bacillus Calmette-Guérin (BCG) treatment after Transurethral Resection of Bladder Tumor (TURB) for intermediate- or high-risk Non-Muscle-Invasive Bladder Cancer (NMIBC) patients, aiming to reduce the risk of tumor recurrence. The quality of data, however, does not allow definitive conclusions on whether different strains and dosages of BCG have different efficacies on long-term survival outcomes...
October 10, 2023: European Urology Oncology
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JOURNAL ARTICLE
E Moreno-Olmedo, G Nagore, L Aakki, I Morales, E Gómez, A Garcia, L Beltran, V Suarez
PURPOSE/OBJECTIVE(S): This prospective clinical trial to evaluated long-term outcomes associated with 2 fractions in a single day, one implant, high-dose-rate (HDR) brachytherapy as monotherapy for patients with localized prostate cancer. We report Genitourinary (GU) and gastrointestinal (GI) toxicity and Disease control. MATERIALS/METHODS: Between November 2010 and Feb 2016 a total of 120 patients diagnosed with low/intermediate-risk localized prostate cancer were treated...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
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JOURNAL ARTICLE
Johannes Breyer, Markus Eckstein, Danijel Sikic, Felix Wezel, Florian Roghmann, Mirco Brehmer, Ralph M Wirtz, Jonas Jarczyk, Philipp Erben, Veronika Bahlinger, Franziska Goldschmidt, Guido Fechner, Jack Chen, Ellen Paxinos, Michael Bates, Maximilian Haas, Friedemann Zengerling, Christian Bolenz, Maximilian Burger, Arndt Hartmann, Maximilian C Kriegmair
To determine whether Xpert bladder cancer monitor, a noninvasive PCR-based biomarker test, can predict the need for 2nd transurethral resection of the bladder (TURB) better than clinical assessment. Patients scheduled for TURB were prospectively screened. After initial TURB, patients were assigned to 2nd TURB or follow-up cystoscopy at 3 months (FU) by clinicians' discretion. Central urine cytology and Xpert monitor tests were performed prior to the 1st TURB and 2nd TURB or FU, respectively. Statistical analysis to compare clinical assessment and Xpert monitor comprised sensitivity (SENS), specificity (SPEC), NPV and PPV...
September 18, 2023: Scientific Reports
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JOURNAL ARTICLE
Mohammad Hasan Larizadeh, Fateme Arabnejad, Mohammad Reza Ebadzadeh
Bladder cancer is diagnosed at older age compared to all other known cancer types. Radical cystectomy after neoadjuvant chemotherapy or tri-modality treatment (consist of TURB, concurrent chemo-radiation) are the standard treatments. Many of the patients cannot receive tri-modality treatment (concurrent chemo-radiation) because of medical comorbidities. The present study assessed the results of sequential use of chemotherapy and radiotherapy versus concurrent use of them in 266 muscle invasive bladder cancer patients...
July 31, 2023: Urology Journal
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JOURNAL ARTICLE
David D'Andrea, Francesco Soria, Rodolfo Hurle, Dmitry Enikeev, Sergey Kotov, Sophie Régnier, Evanguelos Xylinas, Lukas Lusuardi, Axel Heidenreich, Chao Cai, Nicola Frego, Mark Taraktin, Maxim Ryabov, Paolo Gontero, Eva Compérat, Shahrokh F Shariat
BACKGROUND: En bloc transurethral resection of the bladder (eTURB) might improve the surgical management of non-muscle-invasive bladder cancer (NMIBC) in comparison to conventional TURB (cTURB). OBJECTIVE: To evaluate whether eTURB is superior to cTURB in resection of NMIBC and specimen retrieval. DESIGN, SETTING, AND PARTICIPANTS: This was a randomized, multicenter trial in patients with up to three cTa-T1 NMIBC tumors of 1-3 cm in size, who were enrolled from January 2019 to January 2022...
August 3, 2023: European Urology Oncology
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JOURNAL ARTICLE
Vilhelm Pihl, Maria Markus, Johan Abrahamsson, Mats Bläckberg, Oskar Hagberg, Petter Kollberg, Athanasios Simoulis, Elin Trägårdh, Fredrik Liedberg
BACKGROUND: 18 F-Fluorodeoxyglucose positron emission combined with computed tomography (FDG-PET/CT) has been proposed to improve preoperative staging in patients with bladder cancer subjected to radical cystectomy (RC). OBJECTIVE: Our aim was to assess the accuracy of FDG-PET/CT for lymph node staging ascertained at the multidisciplinary tumour board compared to lymph node status in the surgical lymphadenectomy specimen obtained at RC, and to explore potential factors associated with false-positive FDG-PET/CT results...
July 24, 2023: European Journal of Hybrid Imaging
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