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https://www.readbyqxmd.com/read/27908681/preoperative-anemia-is-associated-with-disease-recurrence-and-progression-in-patients-with-non-muscle-invasive-bladder-cancer
#1
Francesco Soria, Marco Moschini, Mohammad Abufaraj, Gregory J Wirth, Beat Foerster, Kilian M Gust, Mehmet Özsoy, Alberto Briganti, Paolo Gontero, Romain Mathieu, Morgan Rouprêt, Pierre I Karakiewicz, Shahrokh F Shariat
PURPOSE: To evaluate the effect of preoperative anemia (PA) on oncological outcomes in a multicenter cohort of patients with non-muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of the bladder (TURB) and adjuvant intravesical therapies. We hypothesize that PA represents a marker of disease aggressiveness and could be used to improve the discrimination of prognostic tools for the prediction of disease recurrence and progression. METHODS: This multicenter retrospective study included 1,117 patients from 4 different centers...
November 28, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27899955/comparison-between-standard-and-reduced-volume-radiotherapy-in-bladder-preservation-trimodality-protocol-for-muscle-invasive-bladder-cancer-patients
#2
Waleed Arafat, Azza Darwish, George E Naoum, Wael Sameh, Gamal El Husseiny, Fathy Abd-El-Gawad, Mostafa Samir
AIM: Our aim is to compare the toxicity, pelvic nodal relapse, and overall survival of whole bladder irradiation only to the standard technique of whole pelvis irradiation followed by bladder boost in patients with muscle-invasive bladder carcinoma undergoing bladder preservation protocol. MATERIAL AND METHOD: A total of 60 patients with transitional cell carcinoma, stage T2-3, N0, M0 bladder cancer were subjected to maximal transurethral resection bladder tumour (TURB)...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27765044/bladder-chondrosarcoma-plus-urothelial-carcinoma-in-recurred-transitional-cell-carcinoma-of-the-upper-urinary-tract-a-case-report-and-literature-review
#3
Min Hyun Cho, Sung Han Kim, Weon Seo Park, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Kang Hyun Lee
BACKGROUND: Sarcomatoid urothelial carcinoma (SUC) is a rare malignant neoplasm of the urinary bladder comprising 0.2-0.6 % of all histological bladder tumor subtypes. It presents as a high-stage malignancy and exhibits aggressive biological behavior, regardless of the treatment employed. It is defined as histologically indistinguishable from sarcoma and as a high-grade biphasic neoplasm with malignant epithelial and mesenchymal components. The mean age of patients presenting with SUC is 66 years, and the male-to-female ratio is 3:1...
October 20, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27712914/-intravesical-instillations-in-non-muscle-invasive-bladder-cancer-nmibc-prospects-for-thermochemotherapy
#4
J Irani
: Non-muscle-invasive bladder cancer (NMIBC) is characterised by a high risk of recurrence when performing only a transurethral resection of the bladder (TURB). Intravesical instillations are performed postoperatively to decrease the rate of recurrence. The standard agents currently used are Mitomycin-C (MMC) or bacillus Calmette-Guérin (BCG). In order to further enhance the efficacy of the adjuvant treatments and/or diminish their side effects, alternative treatments are studied. Intravesical MMC combined with hyperthermia could be an interesting alternative active treatment for intermediate- and possibly high-risk NMIBC, and has been investigated in the past years...
October 3, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27578233/optimised-photodynamic-diagnosis-for-transurethral-resection-of-the-bladder-turb-in-german-clinical-practice-results-of-the-noninterventional-study-optic-iii
#5
Thorsten Bach, Patrick J Bastian, Andreas Blana, Angelika Kaminsky, Stefan Keller, Thomas Knoll, Christoph Lang, Soeren Promnitz, Burkhard Ubrig, Thomas Keller, Bryan Qvick, Maximilian Burger
PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use...
August 30, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27564278/neutrophil-to-lymphocyte-ratio-a-biomarker-in-non-muscle-invasive-bladder-cancer-a-single-institutional-longitudinal-study
#6
Vincenzo Favilla, Tommaso Castelli, Daniele Urzì, Giulio Reale, Salvatore Privitera, Antonio Salici, Giorgio Ivan Russo, Sebastiano Cimino, Giuseppe Morgia
BACKGROUND: Bladder cancer represents one of the most important clinical challenges in urologic practice. In this context, inflammation has an important role in the development and progression of many malignancies. The objective of the present study was to evaluate the prognostic value of pre-treatment Neutrophil to lymphocyte ratio (NLR) on the risk of recurrence and progression in patients with primary non-muscle invasive bladder cancer. MATERIALS AND METHODS: Data obtained from 178 bladder cancer patients who underwent transurethral resection of bladder tumor (TURB) between July 2008 and December 2014 were evaluated prospectively...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27458489/patient-comfort-during-flexible-and-rigid-cystourethroscopy
#7
Wojciech Krajewski, Romuald Zdrojowy, Joanna Wojciechowska, Katarzyna Kościelska, Janusz Dembowski, Michał Matuszewski, Krzysztof Tupikowski, Bartosz Małkiewicz, Anna Kołodziej
INTRODUCTION: Cystourethroscopy (CS) is an endoscopic method used to visualize the urethra and the bladder. AIM: In this study, we prospectively evaluated pain in men undergoing cyclic cystoscopic assessment with rigid and flexible instruments after transurethral resection of bladder tumor (TURB). MATERIAL AND METHODS: One hundred and twenty male patients who were under surveillance after a TURB procedure due to urothelial cell carcinoma and who had undergone at least one rigid cystourethroscopy in the past were enrolled in the trial...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27381893/replacing-cystoscopy-by-urine-markers-in-the-follow-up-of-patients-with-low-risk-non-muscle-invasive-bladder-cancer-an-international-bladder-cancer-network-project
#8
REVIEW
Claudia Schmitz-Dräger, Nadine Bonberg, Beate Pesch, Tilman Todenhöfer, Sevim Sahin, Thomas Behrens, Thomas Brüning, Bernd J Schmitz-Dräger
RATIONALE: Numerous molecular urine markers for the diagnosis of bladder cancer have been developed and evaluated mostly in case-control settings through the past decades. However, despite all efforts none of them has been included into clinical decision-making and guideline recommendations until today. The aim of this retrospective longitudinal analysis was to investigate if a molecular marker might be able to replace cystoscopy as a primary examination in diagnosis and follow-up of patients with pTa grade 1-2 bladder cancer...
October 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27377079/prognostic-impact-of-returb-in-high-grade-t1-primary-bladder-cancer
#9
Roberto Sanseverino, Giorgio Napodano, Antonio Campitelli, Maria Addesso
PURPOSE: To evaluate whether pathological outcomes of ReTURB have a prognostic impact on recurrence and progression of primitive T1HG bladder cancer. MATERIAL AND METHODS: Patients affected by primitive T1HG TCC of bladder underwent restaging TURB (ReTURB). Patients with muscle invasive disease at ReTURB underwent radical cystectomy; those with non-muscle invasive residual (NMI-RT) and those with no residual tumour (NRT) received an intravesical BCG therapy. We compared recurrence and progression in NMIRT patients and NRT patients at restaging TURB...
July 4, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27324428/eau-guidelines-on-non-muscle-invasive-urothelial-carcinoma-of-the-bladder-update-2016
#10
Marko Babjuk, Andreas Böhle, Maximilian Burger, Otakar Capoun, Daniel Cohen, Eva M Compérat, Virginia Hernández, Eero Kaasinen, Joan Palou, Morgan Rouprêt, Bas W G van Rhijn, Shahrokh F Shariat, Viktor Soukup, Richard J Sylvester, Richard Zigeuner
CONTEXT: The European Association of Urology (EAU) panel on Non-muscle-invasive Bladder Cancer (NMIBC) released an updated version of the guidelines on Non-muscle-invasive Bladder Cancer. OBJECTIVE: To present the 2016 EAU guidelines on NMIBC. EVIDENCE ACQUISITION: A broad and comprehensive scoping exercise covering all areas of the NMIBC guidelines published between April 1, 2014, and May 31, 2015, was performed. Databases covered by the search included Medline, Embase, and the Cochrane Libraries...
June 17, 2016: European Urology
https://www.readbyqxmd.com/read/27323781/single-immediate-postoperative-instillation-of-chemotherapy-in-non-muscle-invasive-bladder-cancer-a-systematic-review-and-network-meta-analysis-of-randomized-clinical-trials-using-different-drugs
#11
Minyong Kang, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
We performed a network meta-analysis of randomized controlled trials (RCTs) to compare the efficacy of several intravesical chemotherapeutic (IVC) agents after transurethral resection of bladder tumor (TURB) in non-muscle invasive bladder cancer patients. The literature search was conducted using the Embase, Scopus and PubMed databases for RCTs, including patients with single or multiple, primary or recurrent stage Ta or T1 urothelial carcinoma of the bladder managed with a single, immediate instillation of IVC after TURB...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27316373/development-of-a-preoperative-nomogram-incorporating-biomarkers-of-systemic-inflammatory-response-to-predict-nonorgan-confined-urothelial-carcinoma-of-the-bladder-at-radical-cystectomy
#12
Ilaria Lucca, Sebastian L Hofbauer, Carmen V Leitner, Michela de Martino, Mehmet Özsoy, Martin Susani, Shahrokh F Shariat, Tobias Klatte
OBJECTIVE: To develop a preoperative multivariable decision-making tool to predict nonorgan-confined urothelial carcinoma of the bladder (NOC-UCB) using standard clinical and pathological factors as well as biomarkers of systemic inflammatory response. MATERIALS AND METHODS: We retrospectively analyzed a prospectively maintained single-institutional database comprising 310 patients with clinically N0 M0 UCB who underwent radical cystectomy (RC) with pelvic lymph node dissection without neoadjuvant cisplatin-based chemotherapy (NAC)...
September 2016: Urology
https://www.readbyqxmd.com/read/27106005/can-immediate-second-resection-be-an-alternative-to-standardized-second-transurethral-resection-of-bladder-tumors
#13
Engin Doğantekin, Cengiz Girgin, Sacit Nuri Görgel, Haluk Soylemez, Çetin Dinçel
This study analyzed the impact of an immediate second transurethral resection of bladder tumor (TURBT) protocol on residual tumor status at the initial TURBT session and the recurrence rate in the primary resection area. We prospectively evaluated and randomized 47 consecutive patients who underwent TURBT sessions for bladder cancer. In accordance with the inclusion criteria, of the 47 consecutive patients, 19 (Group I) underwent immediate second resection of the tumor bed after complete TUR and 28 (Group II) did not...
March 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27097964/anti-inflammatory-effects-exerted-by-killox%C3%A2-an-innovative-formulation-of-food-supplement-with-curcumin-in-urology
#14
V Cosentino, A Fratter, M Cosentino
OBJECTIVE: In this Open Controlled Trial we administered an innovative formulation of food supplement with curcumin (Killox®) to test its efficacy, safety and compatibility with other drugs, in the therapy of post-surgery complications of transurethral resection of prostate (TURP) and transurethral resection of bladder (TURB), and in the prevention of late complications. Furthermore, Killox® effects were verified in subjects with benign prostatic hyperplasia (BPH). PATIENTS AND METHODS: Killox® was administered to 40 TURP patients for 20 days, to 10 TURB patients for 10 days and to 30 BPH patients for 60 days...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27085404/evidence-of-terroir-in-milk-sourcing-and-its-influence-on-cheddar-cheese
#15
Gregory Turbes, Tyler D Linscott, Elizabeth Tomasino, Joy Waite-Cusic, Juyun Lim, Lisbeth Meunier-Goddik
The concept of local food is rapidly gaining importance within the United States. The foundation of local food is terroir, which links a food to its production environment. The purpose of this study was to investigate evidence of terroir in milk sourcing and its influence on Cheddar cheese flavor. Specifically, the study was designed to assess if consumers could differentiate between Cheddar cheeses made with milk from different dairy farms. Milk from 5 locations, including single dairy farms and commingled sites, was collected from around the state of Oregon...
July 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27056069/chemohyperthermia-in-non-muscle-invasive-bladder-cancer-an-overview-of-the-literature-and-recommendations
#16
Esmee I M L Liem, Hans Crezee, Jean J de la Rosette, Theo M de Reijke
Non-muscle-invasive bladder cancer (NMIBC) is characterised by a high risk of recurrence for the present standard treatment of transurethral resection of the bladder (TURB) followed by intravesical instillation of Mitomycin-C (MMC) or bacillus Calmette-Guérin (BCG). To decrease this high recurrence rate, alternative treatments are studied. Intravesical MMC combined with hyperthermia could be an interesting alternative active treatment for intermediate- and high-risk NMIBC, and has been investigated in the past years...
June 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/26994461/optimizing-and-real-time-control-of-biofilm-formation-growth-and-renewal-in-denitrifying-biofilter
#17
Xiuhong Liu, Hongchen Wang, Feng Long, Lu Qi, Haitao Fan
A pilot-scale denitrifying biofilter (DNBF) with a treatment capacity of 600m(3)/d was used to study real-time control of biofilm formation, removal and renewal. The results showed biofilm formation, growth and removal can be well controlled using on-line monitored turbidity. The status of filter layer condition can be well indicated by Turb break points on turbidity profile. There was a very good linear relationship between biofilm growth degree (Xbiof) and filter clogging degree (Cfilter) with R(2) higher than 0...
June 2016: Bioresource Technology
https://www.readbyqxmd.com/read/26943538/optimal-length-scale-for-a-turbulent-dynamo
#18
Mira Sadek, Alexandros Alexakis, Stephan Fauve
We demonstrate that there is an optimal forcing length scale for low Prandtl number dynamo flows that can significantly reduce the required energy injection rate. The investigation is based on simulations of the induction equation in a periodic box of size 2πL. The flows considered are the laminar and turbulent ABC flows forced at different forcing wave numbers k_{f}, where the turbulent case is simulated using a subgrid turbulence model. At the smallest allowed forcing wave number k_{f}=k_{min}=1/L the laminar critical magnetic Reynolds number Rm_{c}^{lam} is more than an order of magnitude smaller than the turbulent critical magnetic Reynolds number Rm_{c}^{turb} due to the hindering effect of turbulent fluctuations...
February 19, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/26900355/muscle-invasive-bladder-cancer-treated-with-turb-followed-by-concomitant-boost-with-small-reduction-of-radiotherapy-field-with-or-without-of-chemotherapy
#19
Jadwiga Nowak-Sadzikowska, Tomasz Skóra, Bogumiła Szyszka-Charewicz, Jerzy Jakubowicz
AIM: To evaluate the clinical outcome and toxicity of the treatment of muscle-invasive bladder cancer (MIBC) that combined transurethral resection of bladder tumor (TURB) with "concomitant boost" radiotherapy delivered over a shortened overall treatment time of 5 weeks, with or without concurrent chemotherapy. BACKGROUND: Local control of MIBC by bladder-sparing approach is unsatisfactory. In order to improve the effectiveness of radiotherapy, we have designed a protocol that combines TURB with a non-conventionally fractionated radiotherapy "concomitant boost"...
January 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/26877366/p-067-feature-of-secondary-hypertension
#20
S Derbal, B Ben Kaab, M T Jomni, S Bellakhel, A Mestiri, H Smida, M H Dougui
OBJECTIFS: L'hypertension artérielle secondaire, ne représente que 10 % de l'ensemble de l'HTA tout venant. Les causes d'HTA secondaire sont multiples, regroupant des pathologies essentiellement endocriniennes, rénales et vasculaires. Le but de notre travail est de décrire le profil des sujets explorés pour une HTA secondaire, les étiologies et l'évolution sous traitement. MéTHODES: Nous rapportons le résultat d'une étude rétrospective sur les patients explorés pour une suspicion d'HTA secondaire que nous avons colligé au Service de Médecine Interne de l'Hôpital FSI de Tunis...
December 2015: Annales de Cardiologie et D'angéiologie
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