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deep brain stimulation depression

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https://www.readbyqxmd.com/read/28065487/the-effect-of-unilateral-subthalamic-nucleus-deep-brain-stimulation-on-depression-in-parkinson-s-disease
#1
Elizabeth L Birchall, Harrison C Walker, Gary Cutter, Stephanie Guthrie, Allen Joop, Raima A Memon, Ray L Watts, David G Standaert, Amy W Amara
BACKGROUND: Depression is common in Parkinson's disease (PD) and adversely affects quality of life. Both unilateral and bilateral subthalamic (STN) deep brain stimulation (DBS) effectively treat the motor symptoms of PD, but questions remain regarding the impact of unilateral STN DBS on non-motor symptoms, such as depression. METHODS: We report changes in depression, as measured by the Hamilton Depression Rating Scale (HAMD-17), in 50 consecutive PD patients who underwent unilateral STN DBS...
December 27, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/28061418/memory-and-mood-outcomes-after-anterior-thalamic-stimulation-for-refractory-partial-epilepsy
#2
Alexander I Tröster, Kimford J Meador, Christopher P Irwin, Robert S Fisher
PURPOSE: Bilateral deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces seizures and is relatively safe but may be accompanied by complaints of memory problems and depression. This study examined incidence of memory and depression adverse events (AE) in the SANTE study blinded phase and their relationship to objective neurobehavioral measures, baseline characteristics, quality of life and long-term neurobehavioral outcome. METHOD: The neurobehavioral AE and neuropsychological data from a previously reported prospective randomized trial (SANTE) were analyzed...
December 23, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28049077/computational-models-of-bitemporal-bifrontal-and-right-unilateral-ect-predict-differential-stimulation-of-brain-regions-associated-with-efficacy-and-cognitive-side-effects
#3
S Bai, V Gálvez, S Dokos, D Martin, M Bikson, C Loo
BACKGROUND: Extensive clinical research has shown that the efficacy and cognitive outcomes of electroconvulsive therapy (ECT) are determined, in part, by the type of electrode placement used. Bitemporal ECT (BT, stimulating electrodes placed bilaterally in the frontotemporal region) is the form of ECT with relatively potent clinical and cognitive side effects. However, the reasons for this are poorly understood. OBJECTIVE: This study used computational modelling to examine regional differences in brain excitation between BT, Bifrontal (BF) and Right Unilateral (RUL) ECT, currently the most clinically-used ECT placements...
December 29, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27994542/the-retrograde-connections-and-anatomical-segregation-of-the-g%C3%A3-ttingen-minipig-nucleus-accumbens
#4
Anders C Meidahl, Dariusz Orlowski, Jens C H Sørensen, Carsten R Bjarkam
Nucleus accumbens (NAcc) has been implicated in several psychiatric disorders such as treatment resistant depression (TRD), and obsessive-compulsive disorder (OCD), and has been an ongoing experimental target for deep brain stimulation (DBS) in both rats and humans. In order to translate basic scientific results from rodents to the human setting a large animal model is needed to thoroughly study the effect of such therapeutic interventions. The aim of the study was, accordingly, to describe the basic anatomy of the Göttingen minipig NAcc and its retrograde connections...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27965181/stimulation-of-the-bilateral-anterior-nuclei-of-the-thalamus-in-the-treatment-of-refractory-epilepsy-two-cases-of-subcortical-band-heterotopia
#5
Ana Franco, José Pimentel, Alexandre Rainha Campos, Carlos Morgado, Sara Pinelo, António Gonçalves Ferreira, Carla Bentes
Subcortical band heterotopia is a neuronal migration disorder that may cause refractory epilepsy. In these patients, resective surgery has yielded inadequate results. Deep brain stimulation of the anterior nuclei of the thalamus has been used for the treatment of refractory epilepsy with good results. We describe the first two patients with subcortical band heterotopia who were submitted to deep brain stimulation of the anterior nuclei of the thalamus, with evaluation of seizure outcome after 12 and 18 months of follow-up...
December 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27964870/high-frequency-stimulation-of-the-infralimbic-cortex-induces-morphological-changes-in-rat-hippocampal-neurons
#6
Yarema B Bezchlibnyk, Scellig S D Stone, Clement Hamani, Andres M Lozano
BACKGROUND: Although a significant subset of patients with major depressive disorder (MDD) fail to respond to medical or behavioural therapy, deep brain stimulation (DBS) applied to the subgenual cingulate cortex (SCC; sg25) has been shown to reduce depressive symptoms in a subset of patients. This area receives projections from neurons in the CA1 region and subiculum of the hippocampus (HC), a brain region implicated in the pathobiology and treatment of MDD. OBJECTIVE: To assess whether high frequency stimulation (HFS) of the infralimbic cortex is associated with changes in cellular morphology in the HC...
November 23, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27930748/six-nine-year-follow-up-of-deep-brain-stimulation-for-obsessive-compulsive-disorder
#7
Sarah M Fayad, Andrew G Guzick, Adam M Reid, Dana M Mason, Agustina Bertone, Kelly D Foote, Michael S Okun, Wayne K Goodman, Herbert E Ward
OBJECTIVE: Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) region has shown promise as a neurosurgical intervention for adults with severe treatment-refractory obsessive-compulsive disorder (OCD). Pilot studies have revealed improvement in obsessive-compulsive symptoms and secondary outcomes following DBS. We sought to establish the long-term safety and effectiveness of DBS of the VC/VS for adults with OCD. MATERIALS AND METHODS: A long term follow-up study (73-112 months) was conducted on the six patients who were enrolled in the original National Institute of Mental Health pilot study of DBS for OCD...
2016: PloS One
https://www.readbyqxmd.com/read/27924875/gabab-receptor-mediates-opposing-adaptations-of-gaba-release-from-two-types-of-prefrontal-interneurons-after-observational-fear
#8
Lei Liu, Wataru Ito, Alexei Morozov
The observational fear (OF) paradigm in rodents, in which the subject is exposed to a distressed conspecific, elicits contextual fear learning and enhances future passive avoidance learning, which may model certain behavioral traits resulting from traumatic experiences in humans. Because these behaviors affected by the OF, require dorso-medial prefrontal cortex (dmPFC), we searched for synaptic adaptations in dmPFC resulting from OF in mice by recording synaptic responses in dmPFC layer V pyramidal neurons elicited by repeated 5 Hz electrical stimulation of dmPFC layer I, or by optogenetic stimulation of specific interneurons ex vivo one day after OF...
December 7, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27920671/proceedings-of-the-fourth-annual-deep-brain-stimulation-think-tank-a-review-of-emerging-issues-and-technologies
#9
Wissam Deeb, James J Giordano, Peter J Rossi, Alon Y Mogilner, Aysegul Gunduz, Jack W Judy, Bryan T Klassen, Christopher R Butson, Craig Van Horne, Damiaan Deny, Darin D Dougherty, David Rowell, Greg A Gerhardt, Gwenn S Smith, Francisco A Ponce, Harrison C Walker, Helen M Bronte-Stewart, Helen S Mayberg, Howard J Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L Ostrem, Jonathan B Shute, Joohi Jimenez-Shahed, Kelly D Foote, Aparna Wagle Shukla, Marvin A Rossi, Michael Oh, Michael Pourfar, Paul B Rosenberg, Peter A Silburn, Coralie de Hemptine, Philip A Starr, Timothy Denison, Umer Akbar, Warren M Grill, Michael S Okun
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27900544/gamma-knife-subcaudate-tractotomy-for-treatment-resistant-depression-and-target-characteristics-a-case-report-and-review
#10
Seong-Cheol Park, Jung Kyo Lee, Chan-Hyung Kim, Jin Pyo Hong, Do Hee Lee
Stereotactic subcaudate tractotomy has previously been suggested to be an effective treatment for depression. This is the first study to report the use of gamma-knife subcaudate tractotomy for treatment-resistant depression. A 49-year-old woman with major depressive disorder had been treated for 30 years, with nine suicide attempts during that time. The right and left target maximum diameter was 11 mm within 50 % isodose lines. The target was located more posteriorly and inferiorly than the subgenual cingulate target typically used for deep-brain stimulation...
January 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27872807/identification-of-the-stria-medullaris-thalami-using-diffusion-tensor-imaging
#11
Ryan B Kochanski, Robert Dawe, Daniel B Eddelman, Mehmet Kocak, Sepehr Sani
BACKGROUND: Deep brain stimulation (DBS) via anatomical targeting of white matter tracts defined by diffusion tensor imaging (DTI) may be a useful tool in the treatment of pathologic neurophysiologic circuits implicated in certain disease states like treatment resistant depression (TRD). We sought to determine if DTI could be used to define the stria medullaris thalami (SM), the major afferent white matter pathway to the lateral habenula (LHb), a thalamic nucleus implicated in the pathophysiology of TRD...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27842519/administration-of-electroconvulsive-therapy-for-depression-associated-with-deep-brain-stimulation-in-a-patient-with-post-traumatic-parkinson-s-disease-a-case-study
#12
Miles G Cunningham, Golnaz Yadollahikhales, Gordana Vitaliano, Craig van Horne
BACKGROUND: Deep brain stimulation (DBS) has been shown to be effective for parkinsonian symptoms poorly responsive to medications. DBS is typically well-tolerated, as are the maintenance battery changes. Here we describe an adverse event during a battery replacement procedure that caused rapid onset of severe depression. CASE PRESENTATION: The patient is a 58-year-old woman who was in a serious motor vehicle accident and sustained a concussion with loss of consciousness...
November 15, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27812715/commentary-on-deep-brain-stimulation-for-treatment-refractory-depression
#13
Kathleen Mary Patchan
No abstract text is available yet for this article.
November 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27812714/deep-brain-stimulation-for-treatment-refractory-depression
#14
Puneet Narang, Amber Retzlaff, Kanwarjeet Brar, Steven Lippmann
Depression has a high lifetime prevalence and recurrence rate, with more than one-third of affected patients experiencing treatment-refractory depression. These individuals should benefit from additional treatment options such as deep brain stimulation (DBS), a research-grade intervention. DBS is being investigated for its efficacy in treatment-refractory cases. We reviewed the English-language literature published between the years 2010 and 2015 regarding the utility of DBS for patients with treatment-refractory depression...
November 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27768049/treating-clinical-depression-with-repetitive-deep-transcranial-magnetic-stimulation-using-the-brainsway-h1-coil
#15
David Feifel, Katherine Pappas
Repetitive transcranial magnetic stimulation (rTMS) is an emerging non-pharmacological approach to treating many brain-based disorders. rTMS uses electromagnetic coils to stimulate areas of the brain non-invasively. Deep transcranial magnetic stimulation (dTMS) with the Brainsway H1-coil system specifically is a type of rTMS indicated for treating patients with major depressive disorder (MDD) who are resistant to medication. The unique H1-coil design of this device is able to stimulate neuronal pathways that lie deeper in the targeted brain areas than those reached by conventional rTMS coils...
October 4, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27756252/disappearance-of-treatment-resistant-depression-after-damage-to-the-orbitofrontal-cortex-and-subgenual-cingulate-area-a-case-study
#16
Michitaka Funayama, Motoichiro Kato, Masaru Mimura
BACKGROUND: Although post-stroke depression is a well-characterized disorder, there is less understanding of how pre-existence of depression is affected by a stroke. CASE PRESENTATION: We describe a patient with treatment-resistant major depression, which had been ongoing for 14 years but disappeared shortly after onset of a subarachnoid hemorrhage. Her cognitive function and functional status were mostly unaffected by the stroke. However, she no longer excessively regretted past events...
October 19, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27753157/neuropsychological-outcomes-from-constant-current-deep-brain-stimulation-for-parkinson-s-disease
#17
Alexander I Tröster, Joseph Jankovic, Michele Tagliati, DeLea Peichel, Michael S Okun
OBJECTIVE: The aim of this study was to evaluate the neurobehavioral safety of constant-current subthalamic deep brain stimulation and to compare the neuropsychological effects of stimulation versus electrode placement alone. METHODS: A total of 136 patients with Parkinson's disease underwent bilateral subthalamic device implantation in this randomized trial. Patients received stimulation either immediately after device implantation (n = 101; active stimulation) or beginning 3 months after surgery (n = 35; delayed activation control)...
October 18, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27743900/stimulation-of-subgenual-cingulate-area-decreases-limbic-top-down-effect-on-ventral-visual-stream-a-dbs-eeg-pilot-study
#18
Astrid Kibleur, Mircea Polosan, Pauline Favre, David Rudrauf, Thierry Bougerol, Stéphan Chabardès, Olivier David
Deep brain stimulation (DBS) of the subgenual cingulate gyrus (area CG25) is beneficial in treatment resistant depression. Though the mechanisms of action of Cg25 DBS remain largely unknown, it is commonly believed that Cg25 DBS modulates limbic activity of large networks to achieve thymic regulation of patients. To investigate how emotional attention is influenced by Cg25 DBS, we assessed behavioral and electroencephalographic (EEG) responses to an emotional Stroop task in 5 patients during ON and OFF stimulation conditions...
October 12, 2016: NeuroImage
https://www.readbyqxmd.com/read/27698736/use-of-deep-brain-stimulation-for-major-affective-disorders
#19
Kuanqing Mi
The multifactorial etiology of major affective disorders, such as major depression and bipolar disorder, poses a challenge for identification of effective treatments. In a substantial number of patients, psychopharmacologic treatment does not lead to effective continuous symptom relief. The use of deep brain stimulation (DBS) for treatment-resistant patients is an investigational approach that has recently produced promising results. The recent development of safer stereotaxic neurosurgery, and the combination with functional neuroimaging to map the affected brain circuits, have led to the investigation of DBS as a potential strategy to treat major mood disorders...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27659923/cognitive-outcome-after-ventral-capsule-ventral-striatum-stimulation-for-treatment-resistant-major-depression
#20
Cynthia S Kubu, Tim Brelje, Meryl A Butters, Thilo Deckersbach, Paul Malloy, Paul Moberg, Alexander I Tröster, Eric Williamson, Gordon H Baltuch, Mahendra T Bhati, Linda L Carpenter, Darin D Dougherty, Robert H Howland, Ali R Rezai, Donald A Malone
BACKGROUND: We report the neuropsychological outcome of 25 patients with treatment-resistant major depressive disorder (TRD) who participated in an Institutional Review Board (IRB)-approved randomised double-blind trial comparing active to sham deep brain stimulation (DBS) in the anterior limb of the ventral capsule/ventral striatum (VC/VS). METHODS: Participants were randomised to active (n=12) versus sham (n=13) DBS for 16 weeks. Data were analysed at the individual and group levels...
September 22, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
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