Flávia Sayuri Matsuo, Paulo Henrique Cavalcanti de Araújo, Ryerson Fonseca Mota, Ana Júlia Rossoni Carvalho, Mariana Santos de Queiroz, Beatriz Baldo de Almeida, Karen Cristine de Oliveira Santos Ferreira, Rodrigo Jair Morandi Metzner, Gustavo Duarte Ferrari, Luciane Carla Alberici, Mariana Kiomy Osako
The receptor activator of nuclear factor-κB (NF-κB) (RANK), its ligand (RANKL), and the decoy receptor osteoprotegerin (OPG) are a triad of proteins that regulate bone metabolism, and serum OPG is considered a biomarker for cardiovascular diseases and Type 2 diabetes; however, the implications of OPG in adipose tissue metabolism remains elusive. In this study, we investigate RANK-RANKL-OPG signaling in white adipose tissue browning. Histological analysis of osteoprotegerin knockout (OPG-/-) mice showed subcutaneous white adipose tissue (sWAT) browning, resistance for high-fat diet-induced weight gain, and preserved glucose metabolism compared with wild-type (WT) mice...
June 1, 2020: American Journal of Physiology. Endocrinology and Metabolism