keyword
https://read.qxmd.com/read/34952478/-subclinical-atherosclerosis-in-acromegaly-possible-association-with-cardiovascular-risk-factors-rather-than-disease-activity
#21
JOURNAL ARTICLE
Maria Cristina Costa de Almeida, Claudia Maria Vilas Freire, Maria do Carmo P Nunes, Beatriz Santana Soares, Marcia M Barbosa, Alexandre Varella Giannetti, Giancarlo Pereira Zille, Paulo Augusto Carvalho Miranda, Antonio Ribeiro-Oliveira, Juliana Beaudette Drummond
OBJECTIVE: Cardiovascular (CV) disease is still a major cause of excessive morbidity and mortality in patients with active acromegaly, which may be attributed to a high prevalence of associated pro-atherosclerotic risk factors. However, a direct effect of GH/IGF-1 excess on the vasculature has been previously suggested, warranting further investigation. The present study was designed to investigate whether chronic GH/IGF-1 excess is associated with an increased prevalence of subclinical atherosclerosis in patients with acromegaly...
December 16, 2021: Growth Hormone & IGF Research
https://read.qxmd.com/read/34828034/effects-of-ambient-temperature-on-the-performance-and-thermoregulatory-responses-of-commercial-and-crossbred-brazilian-piau-purebred-sires-%C3%A3-commercial-dams-growing-finishing-pigs
#22
JOURNAL ARTICLE
Vinícius Eduardo Moreira, Renata Veroneze, Alípio Dos Reis Teixeira, Lorena Duarte Campos, Lais Fernanda Lopes Lino, Gabryele Almeida Santos, Bruno Alexander Nunes Silva, Paulo Henrique Reis Furtado Campos
The study aimed at evaluating the effects of high ambient temperature (HT: 30 °C) on the thermoregulatory responses and performance of commercial and Piau crossbred (Brazilian Piau breed sires × commercial genotype dams) growing pigs. Commercial and Piau crossbred pigs were reared under thermoneutral (TN: 22 °C) or HT conditions during a 14-day experimental period. Feeding (daily) and animals (beginning and end) were weighted to obtain performance parameters. Skin and rectal temperatures, respiratory rate, and blood parameters were also measured...
November 19, 2021: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/34814103/association-between-hypertriglyceridemia-and-disease-severity-in-visceral-leishmaniasis
#23
JOURNAL ARTICLE
Mariana Garcez Varela, Mariana de Oliveira Bezerra, Felipe Vieira Santana, Marcos Couto Gomes, Pedro Ribeiro de Jesus Almeida, Geydson Silveira da Cruz, Enaldo Vieira de Melo, Paulo Roberto de Oliveira Costa, Fabrícia Alvisi de Oliveira, Amélia Ribeiro de Jesus, Roque Pacheco de Almeida
Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur that are believed to be related to its progression and severity. This study investigated the associations between serum levels of cholesterol, triglycerides, and lipoproteins (high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein) with clinical and hematological parameters that predict severity in a case series of 83 VL patients...
November 22, 2021: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/34520264/menopause-per-se-is-associated-with-coronary-artery-calcium-score-results-from-the-elsa-brasil
#24
JOURNAL ARTICLE
Marília I H Fonseca, Bianca de Almeida-Pititto, Márcio S Bittencourt, Isabela M Bensenor, Paulo A Lotufo, Sandra R G Ferreira
Background: Menopause and aging deteriorate the metabolic profile, but little is known about how they independently contribute to structural changes in coronary arteries. We compared a broad cardiometabolic risk profile of women according to their menopausal status and investigated if menopause per se is associated with presence of coronary artery calcium (CAC) in the ELSA-Brasil. Materials and Methods: All participants, except perimenopausal women, who had menopause <40 years or from non-natural causes or reported use of hormone therapy were included...
January 2022: Journal of Women's Health
https://read.qxmd.com/read/34452210/magnetoliposomes-based-on-shape-anisotropic-calcium-magnesium-ferrite-nanoparticles-as-nanocarriers-for-doxorubicin
#25
JOURNAL ARTICLE
Beatriz D Cardoso, Ana Rita O Rodrigues, Manuel Bañobre-López, Bernardo G Almeida, Carlos O Amorim, Vítor S Amaral, Paulo J G Coutinho, Elisabete M S Castanheira
Multifunctional lipid nanocarriers are a promising therapeutic approach for controlled drug release in cancer therapy. Combining the widely used liposome structure with magnetic nanoparticles in magnetoliposomes allies, the advantages of using liposomes include the possibility to magnetically guide, selectively accumulate, and magnetically control the release of drugs on target. The effectiveness of these nanosystems is intrinsically related to the individual characteristics of the two main components-lipid formulation and magnetic nanoparticles-and their physicochemical combination...
August 12, 2021: Pharmaceutics
https://read.qxmd.com/read/34408637/the-association-of-metabolic-dysfunction-and-mood-across-lifespan-interacts-with-the-default-mode-network-functional-connectivity
#26
JOURNAL ARTICLE
Carlos Portugal-Nunes, Joana Reis, Ana Coelho, Pedro Silva Moreira, Teresa Costa Castanho, Ricardo Magalhães, Paulo Marques, José Miguel Soares, Liliana Amorim, Pedro Guimarães Cunha, Nadine Correia Santos, Patrício Costa, Joana Almeida Palha, Nuno Sousa, João Miguel Bessa
Background: Numerous studies suggest a relationship between depression and metabolic syndrome, which is likely influenced by age. Interestingly, functional imaging analysis has shown an association between functional connectivity in the default mode network (DMN-FC) and components of metabolic syndrome, which is explored in this study. Methods: From a larger longitudinal cohort study on healthy aging, 943 individuals were extensively characterized for mood and cognition. Among these, 120 individuals who were selected for displaying extreme cognitive performance within the normal range (good and poor performers) were further studied...
2021: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/34234402/intense-pulsed-plus-low-level-light-therapy-in-meibomian-gland-dysfunction
#27
JOURNAL ARTICLE
Ana Marta, Pedro Manuel Baptista, João Heitor Marques, Daniel Almeida, Diana José, Paulo Sousa, Irene Barbosa
PURPOSE: To analyse the clinical outcome in patients with meibomian gland dysfunction (MGD) who underwent intense pulsed light (IPL) plus low-level light therapy (LLL). MATERIALS AND METHODS: The prospective non-comparative study included identified by MGD patients with altered interferometry and lower loss area of the meibomian glands (LAMG), who underwent IPL plus LLL, between July 2020 and August 2020. A multimodal assessment was performed before, 2-3 weeks, and 6 months after treatment...
2021: Clinical Ophthalmology
https://read.qxmd.com/read/34171094/signaling-targets-related-to-antiobesity-effects-of-capsaicin-a-scoping-review
#28
REVIEW
Danielle L Ávila, Núbia A M Nunes, Paulo H R F Almeida, Juliana A S Gomes, Carla O B Rosa, Jacqueline I Alvarez-Leite
The search for new antiobesogenic agents is increasing because of the current obesity pandemic. Capsaicin (Caps), an exogenous agonist of the vanilloid receptor of transient potential type 1 (TRPV1), has shown promising results in the treatment of obesity. This scoping review aims to verify the pathways mediating the effects of Caps in obesity and the different methods adopted to identify these pathways. The search was carried out using data from the EMBASE, MEDLINE (PubMed), Web of Science, and SCOPUS databases...
December 1, 2021: Advances in Nutrition
https://read.qxmd.com/read/33744277/%C3%AE-phellandrene-exhibits-antinociceptive-and-tumor-reducing-effects-in-a-mouse-model-of-oncologic-pain
#29
JOURNAL ARTICLE
Flaviano Ribeiro Pinheiro-Neto, Everton Moraes Lopes, Boris Timah Acha, Laércio da Silva Gomes, Willian Amorim Dias, Antonio Carlos Dos Reis Filho, Bianca de Sousa Leal, Débora Caroline do Nascimento Rodrigues, Jurandy do Nascimento Silva, Dalton Dittz, Paulo Michel Pinheiro Ferreira, Fernanda Regina de Castro Almeida
Medical reports indicate a prevalence of pain in 50% of patients with cancer. In this context, this article investigated the antinociceptive activity of α-PHE using in vivo Sarcoma-180-induced hypernociception in mice to detail its mechanism(s) of antinociception under different conditions of treatment and tumor progression. Firsty, in vitro cytotoxic action was assessed using melanoma B-16/F-10 and S-180 murine cells and colorimetric MTT assays. For in vivo studies, acute treatment with α-PHE (6.25, 12.5, 25 and 50 mg/kg orally by gavage) was performed on the 1st day after S-180 inoculation...
May 1, 2021: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/33725655/postprandial-lipemia-causes-oxidative-stress-in-dogs
#30
JOURNAL ARTICLE
Natália Camila Minucci Bonatto, Paula Lima de Oliveira, Aline Martins Mancebo, Letícia Ramos Costa, Maria Raquel Melo Bosculo, Anelise Maria Bosco, Paulo César Ciarlini, Beatriz Perez Floriano, Luiz Daniel de Barros, Breno Fernando Martins de Almeida
Oxidative stress (OS) has been strongly associated with postprandial lipemia (PPL) in humans, and still requires further investigation in dogs. However, since lipemia interferes with spectrophotometric determinations such as those used to assess OS, the present study investigated the effect of PPL on OS parameters of healthy dogs. Twenty dogs had lipemic postprandial samples compared to the average of two non-lipemic moments. Subsequently, PPL was simulated in vitro using a commercial lipid emulsion and twelve pools of non-lipemic serum of these dogs were used to simulate the minimum, median and maximum concentrations of triglycerides obtained during the lipemic state...
May 2021: Research in Veterinary Science
https://read.qxmd.com/read/33620544/the-antibiotic-peptide-daptomycin-functions-by-reorganizing-the-membrane
#31
REVIEW
Antje Pokorny, Paulo F Almeida
The mechanism of the antimicrobial peptide daptomycin is reviewed and discussed. Daptomycin is a last-resort antibiotic in current use against drug-resistant bacterial infections. Many models have been proposed for its function, most based on the observation that it increases membrane permeability and causes leakage of contents, such as ions and small molecules from bacterial cells and lipid vesicles. However, daptomycin is actually not efficient at permeabilizing or translocating across membranes, contrary to many well-known antimicrobial peptides...
February 2021: Journal of Membrane Biology
https://read.qxmd.com/read/33392994/roux-en-y-gastric-bypass-and-sleeve-gastrectomy-differently-affect-oxidative-damage-markers-and-their-correlations-with-body-parameters
#32
JOURNAL ARTICLE
Fernanda A Venâncio, Leandra A Almeida, Paulo V Zovico, Valério G Barauna, Gustavo P S Miguel, Rogerio G Pedrosa, Fabiano K Haraguchi
BACKGROUND: Bariatric surgery improves oxidative damage, but little is known about the differences between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). This study compared changes in lipid and protein oxidative damage markers and their correlations with body parameters of patients before and after RYGB or SG. METHODS: Body mass index (BMI), bioimpedance parameters, and biochemical parameters including lipid and protein oxidative damage markers were evaluated before and 6 months after surgery...
April 2021: Obesity Surgery
https://read.qxmd.com/read/33305848/strength-training-protects-against-prostate-injury-in-alcoholic-rats
#33
JOURNAL ARTICLE
Giovana Rampazzo Teixeira, Luiz Gustavo Almeida Chuffa, Leonardo Oliveira Mendes, Allice Santos Cruz Veras, James McCabe, Wagner José Favaro, Patricia Fernanda Felipe Pinheiro, João Paulo Arruda Amorim, Otávio Augusto Martins, Wilson Mello-Junior, Francisco Eduardo Martinez
Alcoholic injury can alter the hormonal signaling pathway and lead to glucose and lipid metabolism disorders. In this study, we investigated whether the strength training could exert protective effects against the alterations caused by ethanol consumption on prostatic metabolism. A UChB, ethanol-preferring rats were used in this study. Strength training was conducted for 3 days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a strength training protocol...
May 2021: Journal of Cellular Physiology
https://read.qxmd.com/read/32617258/propionate-metabolism-in-a-human-pathogenic-fungus-proteomic-and-biochemical-analyses
#34
JOURNAL ARTICLE
Luiz Paulo Araújo Santos, Leandro do Prado Assunção, Patrícia de Souza Lima, Gabriel Brum Tristão, Matthias Brock, Clayton Luiz Borges, Mirelle Garcia Silva-Bailão, Célia Maria de Almeida Soares, Alexandre Melo Bailão
Fungi of the complex Paracoccidioides spp. are thermodimorphic organisms that cause Paracoccidioidomycosis, one of the most prevalent mycoses in Latin America. These fungi present metabolic mechanisms that contribute to the fungal survival in host tissues. Paracoccidioides lutzii activates glycolysis and fermentation while inactivates aerobic metabolism in iron deprivation, a condition found during infection. In lungs Paracoccidioides brasiliensis face a glucose poor environment and relies on the beta-oxidation to support energy requirement...
2020: IMA Fungus
https://read.qxmd.com/read/32517183/yeast-sphingolipid-enriched-domains-and-membrane-compartments-in-the-absence-of-mannosyldiinositolphosphorylceramide
#35
JOURNAL ARTICLE
Andreia Bento-Oliveira, Filipa C Santos, Joaquim Trigo Marquês, Pedro M R Paulo, Thomas Korte, Andreas Herrmann, H Susana Marinho, Rodrigo F M de Almeida
The relevance of mannosyldiinositolphosphorylceramide [M(IP)2 C] synthesis, the terminal complex sphingolipid class in the yeast Saccharomyces cerevisiae , for the lateral organization of the plasma membrane, and in particular for sphingolipid-enriched gel-like domains, was investigated by fluorescence spectroscopy and microscopy. We also addressed how changing the complex sphingolipid profile in the plasma membrane could influence the membrane compartments (MC) containing either the arginine/ H+ symporter Can1p (MCC) or the proton ATPase Pma1p (MCP)...
June 6, 2020: Biomolecules
https://read.qxmd.com/read/32315212/rankl-induces-beige-adipocyte-differentiation-in-preadipocytes
#36
JOURNAL ARTICLE
Flávia Sayuri Matsuo, Paulo Henrique Cavalcanti de Araújo, Ryerson Fonseca Mota, Ana Júlia Rossoni Carvalho, Mariana Santos de Queiroz, Beatriz Baldo de Almeida, Karen Cristine de Oliveira Santos Ferreira, Rodrigo Jair Morandi Metzner, Gustavo Duarte Ferrari, Luciane Carla Alberici, Mariana Kiomy Osako
The receptor activator of nuclear factor-κB (NF-κB) (RANK), its ligand (RANKL), and the decoy receptor osteoprotegerin (OPG) are a triad of proteins that regulate bone metabolism, and serum OPG is considered a biomarker for cardiovascular diseases and Type 2 diabetes; however, the implications of OPG in adipose tissue metabolism remains elusive. In this study, we investigate RANK-RANKL-OPG signaling in white adipose tissue browning. Histological analysis of osteoprotegerin knockout (OPG-/-) mice showed subcutaneous white adipose tissue (sWAT) browning, resistance for high-fat diet-induced weight gain, and preserved glucose metabolism compared with wild-type (WT) mice...
June 1, 2020: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/32239466/antioxidant-anti-inflammatory-and-healing-potential-of-ethyl-acetate-fraction-of-bauhinia-ungulata-l-fabaceae-on-in-vitro-and-in-vivo-wound-model
#37
JOURNAL ARTICLE
Raphael de Oliveira Rodrigues, Juliana Navarro Ueda Yaochite, Greyce Luri Sasahara, Andressa Almeida Albuquerque, Said Gonçalves da Cruz Fonseca, Thiago Dias de Vasconcelos Araújo, Gilvandete Maria Pinheiro Santiago, Leôncio Mesquita de Sousa, Jarbas Lima de Carvalho, Ana Paula Negreiros Nunes Alves, Paulo Germano de Carvalho, Aparecida Tiemi Nagao-Dias
The present work aimed to investigate the antioxidant, anti-inflammatory and wound healing potential of ethyl acetate fraction from Bauhinia ungulata L. (FABU) on in vitro and in vivo models. Wound healing assay using human lung adenocarcinoma A549 cell line was employed to evaluate the ability of FABU in modulating cell migration. In addition, a surgical wound model in C57BL/6 mice was used to study the healing potential of FABU incorporated into gel carbomer 940 (Carbopol®). Evaluation of lipid peroxidation, inflammatory and anti-inflammatory mediator gene expression, rate of wound closure, and histological analysis were done...
April 1, 2020: Molecular Biology Reports
https://read.qxmd.com/read/32054053/development-of-novel-magnetoliposomes-containing-nickel-ferrite-nanoparticles-covered-with-gold-for-applications-in-thermotherapy
#38
JOURNAL ARTICLE
Irina S R Rio, Ana Rita O Rodrigues, Carolina P Rodrigues, Bernardo G Almeida, A Pires, A M Pereira, J P Araújo, Elisabete M S Castanheira, Paulo J G Coutinho
Multifunctional nanosystems combining magnetic and plasmonic properties are a promising approach for cancer therapy, allowing magnetic guidance and a local temperature increase. This capability can provide a triggered drug release and synergistic cytotoxic effect in cancer cells. In this work, nickel ferrite/gold nanoparticles were developed, including nickel ferrite magnetic nanoparticles decorated with plasmonic gold nanoparticles and core/shell nanostructures (with a nickel ferrite core and a gold shell)...
February 11, 2020: Materials
https://read.qxmd.com/read/32044653/effect-of-freezing-irradiation-thawing-processes-and-subsequent-aging-on-tenderness-color-and-oxidative-properties-of-beef
#39
JOURNAL ARTICLE
Luana Aparecida Sales, Lorena Mendes Rodrigues, Douglas Roberto Guimarães Silva, Paulo Rogério Fontes, Robledo de Almeida Torres Filho, Alcinéia de Lemos Souza Ramos, Eduardo Mendes Ramos
This study evaluated the use of gamma irradiation (3, 6 and 9 kGy) in frozen vacuum-packed beef and subsequent thawing and aging for up to 14 days. The effects on tenderness, color, and oxidative properties were determined and compared to non-irradiated controls for frozen/thawed and chilled vacuum-packed beef. The combined irradiation and freezing/thawing processes increased total exudate loss and reduced the meat water-holding capacity, regardless of the dose used. Myofibrillar fragmentation was favored by the freezing/thawing processes and negatively affected by irradiation...
February 3, 2020: Meat Science
https://read.qxmd.com/read/31927210/combined-effects-of-gamma-irradiation-and-aging-on-tenderness-and-quality-of-beef-from-nellore-cattle
#40
JOURNAL ARTICLE
Lorena Mendes Rodrigues, Luana Aparecida Sales, Paulo Rogério Fontes, Robledo de Almeida Torres Filho, Monalisa Pereira Dutra Andrade, Alcinéia de Lemos Souza Ramos, Eduardo Mendes Ramos
Combined effects of gamma irradiation (0, 3, 6 and 9 kGy) and aging (1 and 14 days) on quality attributes of vacuum-packaged beef from Nellore cattle were evaluated. The meat water holding capacity was affected by irradiation, increasing (p < 0.05) purge and cooking loss regardless of the dose used. Irradiation negatively affected myofibrillar fragmentation, but samples irradiated at 9 kGy had (p < 0.05) higher soluble collagen and lower shear force values. The meat metmyoglobin reducing activity was reduced (p < 0...
December 31, 2019: Food Chemistry
keyword
keyword
40898
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.