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Paulo Almeida lipid

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https://www.readbyqxmd.com/read/28732311/solid-and-aqueous-magnetoliposomes-as-nanocarriers-for-a-new-potential-drug-active-against-breast-cancer
#1
Ana Rita O Rodrigues, Pedro M F Mendes, Pedro M L Silva, V A Machado, Bernardo G Almeida, J P Araújo, Maria-João R P Queiroz, Elisabete M S Castanheira, Paulo J G Coutinho
Iron oxide nanoparticles, with diameters around 12nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7Oe and a blocking temperature of 118K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28690872/physiological-and-lipid-profile-response-to-acute-exercise-at-different-intensities-in-individuals-with-spinal-cord-injury
#2
Eduardo S Alves, Ronaldo Vt Santos, Francieli S Ruiz, Fabio S Lira, Alexandre A Almeida, Giscard Lima, Thatiana Cs Goni, Lila Oyama, Kate M Edwards, Sergio Tufik, Marco Túlio De Mello
STUDY DESIGN: Experimental and cross-sectional study. OBJECTIVE: To assess the immediate effect of exercise on heart rate (HR), oxygen uptake (VO2), pulmonary ventilation (PV), oxygen pulse (OP), glucose and lipids of wheelchair basketball players with spinal cord injury (SCI). SETTING: Center of Studies in Psychobiology and Exercise-São Paulo, Brazil. METHODS: In all, nine wheelchair basketball players with SCI and nine able-bodied controls (C) performed three exercise sessions at different intensities: ventilatory threshold 1 (VT1), 15% below VT1 and 15% above VT1 with a duration of ~24-34 min...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28489128/obesity-bariatric-surgery-and-oxidative-stress
#3
Roberta Cattaneo Horn, Gabriela Tassotti Gelatti, Natacha Cossettin Mori, Ana Caroline Tissiani, Mariana Spanamberg Mayer, Elvio Almeida Pereira, Marcelo Ross, Paulo Ricardo Moreira, Josiane Woutheres Bortolotto, Tamiris Felippin
Introduction: Obesity refers to the accumulation of fatty tissues and it favors the occurrence of oxidative stress. Alternatives that can contribute to body weight reduction have been investigated in order to reduce the production of reactive oxygen species responsible for tissue damage. The aim of the current study was to assess whether the oxidant and antioxidant markers of obese women before and after bariatric surgery were able to reduce oxidative damage. Method: We have assessed 16 morbidly obese women five days before and 180 days after the surgery...
March 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28454924/dual-effect-of-silymarin-on-experimental-non-alcoholic-steatohepatitis-induced-by-irinotecan
#4
Eudmar Marcolino Assis-Júnior, Anielle Torres Melo, Venúcia Bruna Magalhães Pereira, Deysi Viviana Tenazoa Wong, Nathalia Ribeiro Pinho Sousa, Christiane Mendes Gonçalves Oliveira, Lara Raissa Cavalcante Malveira, Leonardo Silva Moreira, Marcellus Henrique Loiola Ponte Souza, Paulo Roberto Carvalho Almeida, Roberto César Pereira Lima-Júnior
Irinotecan-based regimens are commonly used for treatment of colorectal cancer, which is limited by mucositis and non-alcoholic steatohepatitis (NASH). Silymarin (SIL) prevents fatty liver disease in the clinical setting and in models of liver damage induced chemically. This study investigated the possible effect of SIL on irinotecan (IRI)-induced NASH. Swiss female mice were injected with saline (SAL 5ml/kg i.p.), IRI (50mg/kg i.p.), SIL (150mg/kg p.o.) or IRI (50mg/kg i.p.)+(SIL 1.5, 15 or 150mg/kg p.o.) thrice/week/7weeks...
July 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28429194/photobiomodulation-therapy-associated-with-treadmill-training-in-the-oxidative-stress-in-a-collagen-induced-arthritis-model
#5
Solange Almeida Dos Santos, Marcia Ataize Dos Santos Vieira, Maira Cécilia Brandão Simões, Andrey Jorge Serra, Ernesto Cesar Leal-Junior, Paulo de Tarso Camillo de Carvalho
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic and systemic inflammation, which leads to the destruction of the cartilage and bone and affects tissues in multiple joints. Oxidative stress has been implicated with regards to involvement in various disease conditions, such as diabetes mellitus and neurodegenerative, respiratory, cardiovascular, and RA diseases. In vivo experimental studies using photobiomodulation therapy (PBMT) have shown positive effects in reducing lipid peroxidation and in increasing antioxidant activity...
April 21, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28395280/triple-a-syndrome-preliminary-response-to-the-antioxidant-n-acetylcysteine-treatment-in-a-child
#6
Maria Candida Barisson Villares Fragoso, Edoarda Vasco de Albuquerque Albuquerque, Ana Luiza de Almeida Cardoso, Paula Waki Lopes da Rosa, Rodrigo Bomeny de Paulo, Maria Heloisa Massola Schimizu, Antonio Carlos Seguro, Marisa Passarelli, Katrin Koehler, Angela Huebner, Madson Q Almeida, Ana Claudia Latronico, Ivo Jorge Prado Arnhold, Berenice Bilharinho Mendonca
INTRODUCTION: Triple A syndrome (AAAS) is a rare autosomal recessive disorder characterized by alacrima, achalasia, ACTH-resistant adrenal insufficiency, autonomic dysfunction, and progressive neurodegeneration. Increased oxidative stress, demonstrated in patients' fibroblasts in vitro, may be a central disease mechanism. N-acetylcysteine protects renal function in patients with kidney injuries associated with increased oxidative stress and improves viability of AAAS-knockdown adrenal cells in vitro...
April 10, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28240141/preparation-characterization-and-biocompatibility-studies-of-thermoresponsive-eyedrops-based-on-the-combination-of-nanostructured-lipid-carriers-nlc-and-the-polymer-pluronic-f-127-for-controlled-delivery-of-ibuprofen
#7
Hugo Almeida, Paulo Lobão, Christian Frigerio, Joel Fonseca, Renata Silva, José Manuel Sousa Lobo, Maria Helena Amaral
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs. OBJECTIVE: The aim of this study was to prepare thermoresponsive eyedrops based on the combination of lipid nanoparticles and a thermoresponsive polymer with mucomimetic properties (Pluronic® F-127). MATERIALS AND METHODS: NLCi dispersions were prepared based on the melt-emulsification and ultrasonication technique...
May 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27864069/microencapsulated-sln-an-innovative-strategy-for-pulmonary-protein-delivery
#8
Diana P Gaspar, Carmen Serra, Paulo R Lino, Lídia Gonçalves, Pablo Taboada, Carmen Remuñán-López, António J Almeida
Associating protein with nanoparticles is an interesting strategy to improve their bioavailability and biological activity. Solid lipid nanoparticles (SLN) have been sought as carriers for therapeutic proteins transport to the lung epithelium. Nevertheless, because of their low inertia, nanoparticles intended for pulmonary application usually escape from lung deposition. To overcome this problem, the production of spray-dried powders containing nanoparticles has been recently reported. Herein we developed new hybrid microencapsulated SLN for pulmonary administration, containing a model protein (papain, PAP)...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27760360/charge-distribution-fine-tunes-the-translocation-of-%C3%AE-helical-amphipathic-peptides-across-membranes
#9
Francis D O Ablan, B Logan Spaller, Kaitlyn I Abdo, Paulo F Almeida
Hundreds of cationic antimicrobial and cell-penetrating peptides (CPPs) form amphipathic α-helices when bound to lipid membranes. Here, we test two hypotheses for the differences in the ability of these peptides to translocate across membranes. The first, which we now call the hydrophobicity hypothesis, is that peptide translocation is determined by the Gibbs energy of insertion into the bilayer from the membrane interface. The second, which we call the charge-distribution hypothesis, is that translocation is determined by whether the distribution of cationic residues in the peptide can transiently stabilize a high-energy inserted intermediate by forming salt bridges to the phosphates of lipid headgroups...
October 18, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27720634/coarse-grained-simulations-of-hemolytic-peptide-%C3%AE-lysin-interacting-with-a-popc-bilayer
#10
Mariah J King, Ashley L Bennett, Paulo F Almeida, Hee-Seung Lee
δ-lysin, secreted by a Gram-positive bacterium Staphylococcus aureus, is a 26-residue membrane active peptide that shares many common features with antimicrobial peptides (AMPs). However, it possesses a few unique features that differentiate itself from typical AMPs. In particular, δ-lysin has zero net charge, even though it has many charged residues, and it preferentially lyses eukaryotic cells over bacterial cells. Here, we present the results of coarse-grained molecular dynamics simulations of δ-lysin interacting with a zwitterionic membrane over a wide range of peptide concentrations...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27598982/circulating-early-biomarkers-of-atherogenesis-in-participants-of-the-longitudinal-study-of-adult-health-elsa-brasil-without-diabetes-or-cardiovascular-disease
#11
Bianca de Almeida-Pititto, Fernando Flexa Ribeiro-Filho, Sandhi Barreto, Bruce B Duncan, Maria Inês Schmidt, Paulo A Lotufo, Isabela M Bensenor, Sandra R G Ferreira
Objective: Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods: This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27580834/nutritionists-health-study-cohort-a-web-based-approach-of-life-events-habits-and-health-outcomes
#12
Luciana Gavilan Dias Folchetti, Isis Tande da Silva, Bianca de Almeida-Pititto, Sandra Roberta G Ferreira
INTRODUCTION: Non-communicable chronic diseases (NCCDs) represent a burden for public health. Alongside the established cardiometabolic risk factors such as high blood pressure and disorders of glucose and lipid metabolism, living habits and nutritional status at different stages of life are seen as contributors to this scenario. Gut microbiota composition and subclinical inflammation have been pointed out as underlying mechanisms of NCCDs. Studies involving health professionals have brought relevant contributions to the knowledge about risk factors...
2016: BMJ Open
https://www.readbyqxmd.com/read/27550907/association-between-carotid-intima-media-thickness-and-adiponectin-in-participants-without-diabetes-or-cardiovascular-disease-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#13
Bianca de Almeida-Pititto, Fernando Flexa Ribeiro-Filho, Itamar S Santos, Paulo A Lotufo, Isabela M Bensenor, Sandra Rg Ferreira
Objective The study assessed the association of adiponectin concentration with carotid intima-media thickness (CIMT) in middle-aged participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease. Design Cross-sectional analyses. Methods A sample of 687 individuals (35-54 years old) without diabetes or cardiovascular disease was stratified into two categories according to CIMT (< or ≥ 75th percentile). Traditional risk factors, C-reactive protein and adiponectin values were compared between categories by Student's t-test and frequencies by chi-square test...
January 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27329273/physiological-differences-in-the-crab-ucides-cordatus-from-two-populations-inhabiting-mangroves-with-different-levels-of-cadmium-contamination
#14
Priscila Ortega, Hector A Vitorino, Renata G Moreira, Marcelo A A Pinheiro, Alaor A Almeida, Márcio R Custódio, Flávia P Zanotto
Crustaceans found in metal-contaminated regions are able to survive, and the authors investigated the physiological mechanisms involved by comparing populations from contaminated and noncontaminated areas. The objective of the present study was to measure the cellular transport of a nonessential metal (cadmium [Cd]) in gills and hepatopancreas of Ucides cordatus, together with cell membrane fluidity, metallothionein levels, and lipid peroxidation. The 2 populations compared were from a polluted and a nonpolluted mangrove area of São Paulo State, Brazil...
February 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27102234/biodistribution-of-polyacrylic-acid-coated-iron-oxide-nanoparticles-is-associated-with-proinflammatory-activation-and-liver-toxicity
#15
Diana Couto, Marisa Freitas, Vera Marisa Costa, Renan Campos Chisté, Agostinho Almeida, M Arturo Lopez-Quintela, José Rivas, Paulo Freitas, Paula Silva, Félix Carvalho, Eduarda Fernandes
Iron oxide nanoparticles (IONs) have physical and chemical properties that render them useful for several new biomedical applications. Still, so far, in vivo safety studies of IONs with coatings of biomedical interest are still scarce. The aim of this study, therefore, was to clarify the acute biological effects of polyacrylic acid (PAA)-coated IONs, by determining their biodistribution and their potential proinflammatory and toxic effects in CD-1 mice. The biodistribution of PAA-coated IONs in several organs (liver, spleen, kidneys, brain, heart, testes and lungs), the plasma cytokines, chemokine and aminotransferases levels, white blood cell count, oxidative stress parameters, adenosine triphosphate and histologic features of liver, spleen and kidneys were evaluated 24 h after a single acute (8, 20 or 50 mg kg(-1) ) intravenous administration of PAA-coated IONs in magnetite form...
October 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27001052/copy-number-variations-and-genome-wide-associations-reveal-putative-genes-and-metabolic-pathways-involved-with-the-feed-conversion-ratio-in-beef-cattle
#16
Miguel Henrique de Almeida Santana, Gerson Antônio Oliveira Junior, Aline Silva Mello Cesar, Mateus Castelani Freua, Rodrigo da Costa Gomes, Saulo da Luz E Silva, Paulo Roberto Leme, Heidge Fukumasu, Minos Esperândio Carvalho, Ricardo Vieira Ventura, Luiz Lehmann Coutinho, Haja N Kadarmideen, José Bento Sterman Ferraz
The use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore (Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window...
November 2016: Journal of Applied Genetics
https://www.readbyqxmd.com/read/26511617/ulcer-healing-and-mechanism-s-of-action-involved-in-the-gastroprotective-activity-of-fractions-obtained-from-syngonanthus-arthrotrichus-and-syngonanthus-bisulcatus
#17
Leônia Maria Batista, Gedson Rodrigues De Morais Lima, Ana Beatriz Albino De Almeida, Luciana De Pietro Magri, Tamara Regina Calvo, Anderson Luiz Ferreira, Cláudia Helena Pellizzon, Clélia Akiko Hiruma-Lima, Wagner Vilegas, Paulo Takeo Sano, Alba Regina Monteiro Souza Brito
BACKGROUND: Syngonanthus arthrotrichus and Syngonanthus bisulcatus, currently known for Comanthera aciphylla (Bong.) L.R.Parra & Giul. and Comanthera bisulcata (Koern.) L.R. Parra & Giul, popularly known in Brazil as "sempre-vivas," are plants from the family Eriocaulaceae. They are found in the states of Minas Gerais and Bahia. The species are known to be rich in flavonoids to which their gastroprotective activity has been attributed. In this research, experimental protocols were performed to elucidate the associated mechanisms of action...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26156583/effect-of-jabuticaba-peel-extract-on-lipid-oxidation-microbial-stability-and-sensory-properties-of-bologna-type-sausages-during-refrigerated-storage
#18
Patrícia Leal de Almeida, Silvério Nepomuceno de Lima, Luciene Lacerda Costa, Cintia Cristina de Oliveira, Karina Aparecida Damasceno, Bibiana Alves dos Santos, Paulo Cezar Bastianello Campagnol
This study investigated the lipid oxidation and the microbiological and sensory quality of Bologna-type sausages produced with the addition of jabuticaba peel extract (JPE). Instrumental parameters of color (L*, a* and b*), pH, thiobarbituric acid reactive substance (TBARS) values, microbiological profile, and sensory properties were determined during 35 days of storage. The addition of JPE had an effect on pH and protected the samples from color changes during storage. However, JPE had no positive effect on microbial stability during storage...
December 2015: Meat Science
https://www.readbyqxmd.com/read/26095537/magnetic-liposomes-based-on-nickel-ferrite-nanoparticles-for-biomedical-applications
#19
Ana Rita O Rodrigues, I T Gomes, Bernardo G Almeida, J P Araújo, Elisabete M S Castanheira, Paulo J G Coutinho
Nickel ferrite nanoparticles with superparamagnetic behavior at room temperature were synthesized using a coprecipitation method. These magnetic nanoparticles were either covered with a lipid bilayer, forming dry magnetic liposomes (DMLs), or entrapped in liposomes, originating aqueous magnetoliposomes (AMLs). A new and promising method for the synthesis of DMLs is described. The presence of the lipid bilayer in DMLs was confirmed by FRET (Förster Resonance Energy Transfer) measurements between the fluorescent-labeled lipids NBD-C12-HPC (NBD acting as a donor) included in the second lipid layer and rhodamine B-DOPE (acceptor) in the first lipid layer...
July 21, 2015: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/25959567/intestinal-morphology-adjustments-caused-by-dietary-restriction-improves-the-nutritional-status-during-the-aging-process-of-rats
#20
Mônica de Oliveira Belém, Carla Possani Cirilo, Ana Paula de Santi-Rampazzo, João Paulo Ferreira Schoffen, Jurandir Fernando Comar, Maria Raquel Marçal Natali, Eduardo José de Almeida Araújo
During the aging process, the body's systems change structurally and loss of function can occur. Ingesting a smaller amount of food has been considered a plausible proposal for increased longevity with the quality of life. However, the effects of dietary restriction (DR) during aging are still poorly understood, especially for organs of the digestive system. This study aimed to describe the body weight, oxidative status and possible morphological changes of the intestinal wall of rats submitted to DR during the aging process (7 to 18months old)...
September 2015: Experimental Gerontology
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