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https://www.readbyqxmd.com/read/28317745/the-impact-of-rhizopus-oryzae-cultivation-on-rice-bran-gamma-oryzanol-recovery-and-its-antioxidant-properties
#1
Kelly Cristina Massarolo, Taiana Denardi de Souza, Carolina Carvalho Collazzo, Eliana Badiale Furlong, Leonor Almeida de Souza Soares
This study evaluated the effect of the solid state cultivation (SSC) time of rice bran by Rhizopus oryzae on γ-oryzanol recovery and its antioxidant properties. Gamma-oryzanol was extracted with organic solvents and its extracts were characterized by GC-FID and HPLC-UV. The antioxidant capacity was assessed by DPPH and ABTS(+) assays, β-carotene/linoleic acid system, and reduction of oxidation in lipid system. The biomass showed the γ-oryzanol recovery increased by 51.5% (20.52mg/g), and 5.7% in polyunsaturated fatty acids...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28306733/hypervirulent-mycobacterium-tuberculosis-strain-triggers-necrotic-lung-pathology-associated-with-enhanced-recruitment-of-neutrophils-in-resistant-c57bl-6-mice
#2
Fabrício M Almeida, Thatiana L B Ventura, Eduardo P Amaral, Simone C M Ribeiro, Sanderson D Calixto, Marcelle R Manhães, Andreza L Rezende, Giliane S Souzal, Igor S de Carvalho, Elisangela C Silva, Juliana Azevedo da Silva, Eulógio C Q Carvalho, Afranio L Kritski, Elena B Lasunskaia
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) that in most cases induces irreversible necrosis of lung tissue as a result of excessive inflammatory reactions. The murine model of TB in resistant C57BL/6 mice infected with reference Mtb strains is widely used in TB studies; however, these mice do not show a necrotic pathology, which restricts their use in studies of irreversible tissue damage. Recently, we demonstrated that necrotic lung lesions could be induced in the C57BL/6 mice by highly virulent Mtb strains belonging to the modern Beijing sublineage...
2017: PloS One
https://www.readbyqxmd.com/read/28302419/intravenous-15-isoflurane-lipid-nanoemulsion-for-general-anesthesia-in-dogs
#3
Claudio C Natalini, Carolina L Krahn, Priscila B S Serpa, Joanna E Griffith, Ricardo Miyasaka de Almeida
OBJECTIVE: To investigate the efficacy of a new intravenous (IV) nanoemulsified isoflurane formulation for maintenance of general anesthesia in dogs. STUDY DESIGN: Prospective, crossover, experimental study. ANIMALS: Seven healthy, mature, mixed-breed dogs, three male and four female, weighing 11.5 ± 1.5 kg. METHODS: Anesthesia was induced with propofol for instrumentation. Measurements were obtained before administration of either inhaled isoflurane (Iso-I) or IV 15% isoflurane-loaded lipid nanoemulsion (Iso-nano)...
January 7, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28288928/in%C3%A2-vitro-cytotoxicity-evaluation-of-resveratrol-loaded-nanoparticles-focus-on-the-challenges-of-in%C3%A2-vitro-methodologies
#4
V Rocha, C Marques, J L Figueiredo, A R Gaio, P C Costa, J M Sousa Lobo, I F Almeida
Assessment of toxic effects is mandatory before market placement of pharmaceutical and cosmetic products. Nanotoxicology is an emerging regulatory concern and still a challenging field. Topical application of resveratrol (RSV) has been extensively studied owing to its multi-mechanistic skin anti-aging effects. Nanoencapsulation has been suggested as a promising solution to overcome RSV stability issues. In this work RSV-loaded solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were prepared using a homogenization/sonication technique...
March 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28286284/pre-clinical-investigation-of-diabetes-mellitus-as-a-risk-factor-for-schizophrenia
#5
Alexandra S Almeida Heylmann, Lara Canever, Katia Gress, Sarah T Gomes, Isadora Fachim, Carolina Michels, Geórgia C Stopassoli, Gustavo A Mastella, Amanda V Steckert, Adriani P Damiani, Vanessa M de Andrade, João Quevedo, Alexandra I Zugno
This study investigated the behavioral and biochemical parameters of DM1 as a risk factor in an animal model of schizophrenia (SZ). All groups: 1 Control (saline+saline); 2 Alloxan (alloxan+saline); 3 Ketamine (saline+ketamine); 4 (Alloxan+Ketamine) were fasted for a period of 18h before the subsequent induction of DM via a single intraperitoneal (i.p) injection of alloxan (150mg/kg). From the 4th to the 10th days, the animals were injected i.p with ketamine (25mg/kg) or saline, once a day, to induce a model of SZ and 30min after the last administration were subjected to behavioral testing...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28273617/toxic-effects-of-the-antihistamine-cetirizine-in-mussel-mytilus-galloprovincialis
#6
Miguel Teixeira, Ângela Almeida, Vânia Calisto, Valdemar I Esteves, Rudolf J Schneider, Frederick J Wrona, Amadeu M V M Soares, Etelvina Figueira, Rosa Freitas
Recent studies have become increasingly focused on the assessment of pharmaceuticals occurrence in aquatic ecosystems, however the potential toxicity to non-target organisms is still largely unknown. The antihistamine cetirizine is a commonly used pharmaceutical, already detected in surface waters of marine aquatic systems worldwide. In the present study Mytilus galloprovincialis mussels were exposed to a range of cetirizine concentrations (0.3, 3.0, 6.0 and 12.0 μg/L), resembling moderate to highly contaminated areas, over 28 days...
March 5, 2017: Water Research
https://www.readbyqxmd.com/read/28261812/the-fatty-acid-profile-of-fat-depots-from-santa-in%C3%A3%C2%AAs-sheep-fed-spineless-cactus-opuntia-ficus-indica-mill
#7
Roberto G Costa, Michelly D A Almeida, George Rodrigo B Cruz, Edvaldo M Beltrão Filho, Neila L Ribeiro, Marta S Madruga, Rita de Cássia R E Queiroga
BACKGROUND: Fat is the tissue that varies most in animals from both a quantitative and distribution perspective. It plays a fundamental biological role as energy storage during food scarcity. Renal, pelvic and internal fat are deposited first. These fats are used identify fatty acid profiles that may be considered beneficial or unhealthy. The aim of this study is to evaluate the fatty acid profile of fat depots in Santa Inês sheep finished in confinement with spineless cactus in their diets...
March 6, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28241426/zinc-status-biomarkers-and-cardiometabolic-risk-factors-in-metabolic-syndrome-a-case-control-study
#8
Erika P S Freitas, Aline T O Cunha, Sephora L S Aquino, Lucia F C Pedrosa, Severina C V C Lima, Josivan G Lima, Maria G Almeida, Karine C M Sena-Evangelista
Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p < 0...
February 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28240141/preparation-characterization-and-biocompatibility-studies-of-thermoresponsive-eyedrops-based-on-the-combination-of-nanostructured-lipid-carriers-nlc-and-the-polymer-pluronic-f-127-for-controlled-delivery-of-ibuprofen
#9
Hugo Almeida, Paulo Lobão, Christian Frigerio, Joel Fonseca, Renata Silva, José Manuel Sousa Lobo, Maria Helena Amaral
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs. OBJECTIVE: The aim of this study was to prepare thermoresponsive eyedrops based on the combination of lipid nanoparticles and a thermoresponsive polymer with mucomimetic properties (Pluronic® F-127). MATERIALS AND METHODS: NLCi dispersions were prepared based on the melt-emulsification and ultrasonication technique...
May 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28230298/vitamin-e-nanoemulsion-activity-on-stored-red-blood-cells
#10
C A L Silva, C A Azevedo Filho, G Pereira, D C N Silva, M C A B Castro, A F Almeida, S C A Lucena, B S Santos, M L Barjas-Castro, A Fontes
BACKGROUND: Stored red blood cells (RBCs) undergo numerous changes that have been termed RBC storage lesion, which can be related to oxidative damage. Vitamin E is an important antioxidant, acting on cell lipids. Thus, this study aimed to investigate vitamin E activity on stored RBCs. METHODS: We prepared a vitamin E nanoemulsion that was added to RBC units and stored at 4 °C. Controls, without vitamin E, were kept under the same conditions. Reactive oxygen species (ROS) production was monitored for up to 35 days of storage...
February 23, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28185186/eicosacell-an-imaging-based-assay-to-identify-spatiotemporal-eicosanoid-synthesis
#11
Christianne Bandeira-Melo, Ligia Almeida Paiva, Natália R T Amorim, Peter F Weller, Patricia T Bozza
Eicosanoids are bioactive lipids derived from enzymatic metabolism of arachidonic acid via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways. These lipids are newly formed and nonstorable molecules that have important roles in physiological and pathological processes. The particular interest to determine intracellular compartmentalization of eicosanoid-synthetic machinery has emerged as a key component in the regulation of eicosanoid synthesis and in delineating functional intracellular and extracellular actions of eicosanoids...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28167915/the-role-of-acute-intermittent-hypoxia-in-neutrophil-generated-superoxide-sympathovagal-balance-and-vascular-function-in-healthy-subjects
#12
Germana P L Almeida, Ivani C Trombetta, Felipe X Cepeda, Elaine Hatanaka, Rui Curi, Cristiano Mostarda, Maria C Irigoyen, José A S Barreto-Filho, Eduardo M Krieger, Fernanda M Consolim-Colombo
Introduction: Recurrent hypoxia (HPX), a hallmark of the obstructive sleep apnea (OSA), impairs autonomic balance, and increases arterial blood pressure (BP). Oxidative stress is one of the mechanisms involved in these alterations. The cumulative effect of acute intermittent HPX and the chronicity may determine whether the response crosses the threshold from having protective value to pathology. However, the impact of acute intermittent HPX-reoxygenation on markers of oxidative stress in healthy individuals remains to be fully understood...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28152396/insulin-resistance-atherogenicity-and-iron-metabolism-in-multiple-sclerosis-with-and-without-depression-associations-with-inflammatory-and-oxidative-stress-biomarkers-and-uric-acid
#13
Sayonara Rangel Oliveira, Ana Paula Kallaur, Josiane Lopes, Andrea Name Colado Simão, Edna Maria Vissoci Reiche, Elaine Regina Delicato de Almeida, Helena Kaminami Morimoto, Wildea Lice de Carvalho Jennings de Pereira, Daniela Frizon Alfieri, Tamires Flauzino, Caio de Meleck Proença, Anna Maria Gomes, Damacio Ramón Kaimen-Maciel, Michael Maes
Depression is accompanied by metabolic disorders in iron metabolism, lipoproteins, and insulin resistance. We measured plasma levels of ferritin, iron, lipids, insulin, and glucose and computed the homeostasis model assessment (HOMA2IR) and atherogenic index of plasma (AIP) in MS patients with and without depression and healthy controls. Explanatory variables were serum uric acid, interleukin (IL)-6, lipid hydroperoxides (CL-LOOH), albumin, and C-reactive protein (CRP). Depression was assessed using the Hospital Anxiety and Depression Scale (HADS), neurological disability using the Expanded Disability Status Scale (EDSS), and disease progression using ∆EDSS over five years earlier...
April 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28062841/metal-based-superoxide-dismutase-and-catalase-mimics-reduce-oxidative-stress-biomarkers-and-extend-life-span-of-saccharomyces-cerevisiae
#14
Thales de P Ribeiro, Fernanda L Fonseca, Mariana D C de Carvalho, Rodrigo M da C Godinho, Fernando Pereira de Almeida, Tatiana D Saint'Pierre, Nicolás A Rey, Christiane Fernandes, Adolfo Horn, Marcos D Pereira
Aging is a natural process characterized by several biological changes. In this context, oxidative stress appears as a key factor that leads cells and organisms to severe dysfunctions and diseases. To cope with reactive oxygen species and oxidative-related damage, there has been increased use of superoxide dismutase (SOD)/catalase (CAT) biomimetic compounds. Recently, we have shown that three metal-based compounds {[Fe(HPClNOL)Cl2]NO3, [Cu(HPClNOL)(CH3CN)](ClO4)2 and Mn(HPClNOL)(Cl)2}, harboring in vitro SOD and/or CAT activities, were critical for protection of yeast cells against oxidative stress...
January 15, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28025494/effect-of-elderberry-sambucus-nigra-l-extract-supplementation-in-stz-induced-diabetic-rats-fed-with-a-high-fat-diet
#15
Ângelo C Salvador, Ewelina Król, Virgínia C Lemos, Sónia A O Santos, Fernanda P M S Bento, Carina P Costa, Adelaide Almeida, Dawid Szczepankiewicz, Bartosz Kulczyński, Zbigniew Krejpcio, Armando J D Silvestre, Sílvia M Rocha
Elderberry (Sambucus nigra L.) lipophilic and polar extract dietary supplementation effects were evaluated according to diabetes management indices, using an in vivo model. A research pipeline was constructed, that ranged from extract preparation, partial chemical characterization and toxicity evaluation, to examining the elderberry extract dietary supplementation effects on biofluid and tissues. Extracts toxicity was screened using an Aliivibrio fischeri bioluminescence model. A concentration of up to 60 mg/L was selected, and rat doses for oral supplementation were computed applying the interspecies correlation between A...
December 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28009846/polyphenol-composition-antioxidant-activity-and-cytotoxicity-of-seeds-from-two-underexploited-wild-licania-species-l-rigida-and-l-tomentosa
#16
Igor Parra Pessoa, José Joaquim Lopes Neto, Thiago Silva de Almeida, Davi Felipe Farias, Leonardo Rogério Vieira, Jackeline Lima de Medeiros, Aline Augusti Boligon, Ad Peijnenburg, Ivan Castelar, Ana Fontenele Urano Carvalho
Studies have shown the benefit of antioxidants in the prevention or treatment of human diseases and promoted a growing interest in new sources of plant antioxidants for pharmacological use. This study aimed to add value to two underexploited wild plant species (Licania rigida) and L. tomentosa) from Brazilian flora. Thus, the phenolic compounds profile of their seed ethanol extract and derived fractions were elucidated by HPLC, the antioxidant capacity was assessed by in vitro chemical tests and the cytotoxicity determined using the human carcinoma cell lines MCF-7 and Caco-2...
December 21, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28002744/structural-and-dynamic-insights-of-the-interaction-between-tritrpticin-and-micelles-an-nmr-study
#17
Talita L Santos, Adolfo Moraes, Clovis R Nakaie, Fabio C L Almeida, Shirley Schreier, Ana Paula Valente
A large number of antimicrobial peptides (AMPs) acts with high selectivity and specificity through interactions with membrane lipid components. These peptides undergo complex conformational changes in solution; upon binding to an interface, one major conformation is stabilized. Here we describe a study of the interaction between tritrpticin (TRP3), a cathelicidin AMP, and micelles of different chemical composition. The peptide's structure and dynamics were examined using one-dimensional and two-dimensional NMR...
December 20, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27935992/intense-exercise-and-aerobic-conditioning-associated-with-chromium-or-l-carnitine-supplementation-modified-the-fecal-microbiota-of-fillies
#18
Maria Luiza Mendes de Almeida, Walter Heinz Feringer, Júlia Ribeiro Garcia Carvalho, Isadora Mestriner Rodrigues, Lilian Rezende Jordão, Mayara Gonçalves Fonseca, Adalgiza Souza Carneiro de Rezende, Antonio de Queiroz Neto, J Scott Weese, Márcio Carvalho da Costa, Eliana Gertrudes de Macedo Lemos, Guilherme de Camargo Ferraz
Recent studies performed in humans and rats have reported that exercise can alter the intestinal microbiota. Athletic horses perform intense exercise regularly, but studies characterizing horse microbiome during aerobic conditioning programs are still limited. Evidence has indicated that this microbial community is involved in the metabolic homeostasis of the host. Research on ergogenic substances using new sequencing technologies have been limited to the intestinal microbiota and there is a considerable demand for scientific studies that verify the effectiveness of these supplements in horses...
2016: PloS One
https://www.readbyqxmd.com/read/27880808/natural-schistosoma-mansoni-infection-in-the-wild-reservoir-nectomys-squamipes-leads-to-excessive-lipid-droplet-accumulation-in-hepatocytes-in-the-absence-of-liver-functional-impairment
#19
Kátia B Amaral, Thiago P Silva, Kássia K Malta, Lívia A S Carmo, Felipe F Dias, Mariana R Almeida, Gustavo F S Andrade, Jefferson S Martins, Roberto R Pinho, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
Schistosomiasis is a neglected tropical disease of a significant public health impact. The water rat Nectomys squamipes is one of the most important non-human hosts in the schistosomiasis mansoni transmission in Brazil, being considered a wild reservoir. Cellular mechanisms that contribute to the physiological adaptation of this rodent to the Schistosoma mansoni parasite are poorly understood. Here we identified, for the first time, that a hepatic steatosis, a condition characterized by excessive lipid accumulation with formation of lipid droplets (LDs) within hepatocytes, occurs in response to the natural S...
2016: PloS One
https://www.readbyqxmd.com/read/27871882/schistosomal-derived-lysophosphatidylcholine-triggers-m2-polarization-of-macrophages-through-ppar%C3%AE-dependent-mechanisms
#20
Leonardo Santos Assunção, Kelly G Magalhães, Alan Brito Carneiro, Raphael Molinaro, Patrícia E Almeida, Georgia C Atella, Hugo C Castro-Faria-Neto, Patrícia T Bozza
Mansonic schistosomiasis is a disease caused by the trematode Schistosoma mansoni, endemic to tropical countries. S. mansoni infection induces the formation of granulomas and potent polarization of Th2-type immune response. There is great interest in understanding the mechanisms used by this parasite that causes a modulation of the immune system. Recent studies from our group demonstrated that lipids of S. mansoni, including lysophosphatidylcholine (LPC) have immunomodulatory activity. In the present study, our aim was to investigate the role of lipids derived from S...
February 2017: Biochimica et Biophysica Acta
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