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https://www.readbyqxmd.com/read/29130685/daptomycin-phosphatidylglycerol-domains-in-lipid-membranes
#1
Mark A Kreutzberger, Antje Pokorny, Paulo F Almeida
Daptomycin is an acidic, 13-amino acid, cyclic polypeptide that contains a number of nonproteinogenic residues and is modified at its N-terminus with a decanoyl chain. It has been in clinical use since 2003 against selected drug-resistant Staphylococcus aureus and Enterococcus spp infections. In vitro, daptomycin is active against Gram-positive pathogens at low concentrations but its antibiotic activity depends critically on the presence of calcium ions. This dependence has been thought to arise from binding of one or two Ca(2+) ions to daptomycin as a required step in its interaction with the bacterial membrane...
November 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29126754/effect-of-pulsed-therapeutic-ultrasound-and-diosmin-on-skeletal-muscle-oxidative-parameters
#2
Luis Fernando Sousa Filho, Paula P Menezes, Dayanne Valéria Soares Santana, Bruno S Lima, Shanmugan Saravanan, Grace Kelly M Almeida, José Evaldo R Menezes Filho, Marta M B Santos, Adriano Antunes A S Araújo, Evaleide Diniz de Oliveira
Cyclodextrins (CDs) have been widely used as a promising alternative in the formation of inclusion complexes with poorly soluble molecules. From this perspective, the present study aimed to study the inclusion complexes of diosmin in β-cyclodextrin, chemically quantify the diosmin-in-gel preparation and analyze the stability of the gels. Furthermore, we evaluated the effect of therapeutic pulsed ultrasound (TPU) in association with the gel-diosmin complex on the parameters of muscle damage and oxidative stress in rats...
November 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29110748/perinatal-maternal-high-fat-diet-induces-early-obesity-and-sex-specific-alterations-of-the-endocannabinoid-system-in-white-and-brown-adipose-tissue-of-weanling-rat-offspring
#3
Mariana M Almeida, Camilla P Dias-Rocha, André S Souza, Mariana F Muros, Leonardo S Mendonca, Carmen C Pazos-Moura, Isis H Trevenzoli
Perinatal maternal high-fat (HF) diet programmes offspring obesity. Obesity is associated with overactivation of the endocannabinoid system (ECS) in adult subjects, but the role of the ECS in the developmental origins of obesity is mostly unknown. The ECS consists of endocannabinoids, cannabinoid receptors (cannabinoid type-1 receptor (CB1) and cannabinoid type-2 receptor (CB2)) and metabolising enzymes. We hypothesised that perinatal maternal HF diet would alter the ECS in a sex-dependent manner in white and brown adipose tissue of rat offspring at weaning in parallel to obesity development...
November 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29098221/the-molecular-mechanism-of-nystatin-action-is-dependent-on-the-membrane-biophysical-properties-and-lipid-composition
#4
A G Dos Santos, J T Marquês, A C Carreira, I R Castro, A S Viana, M-P Mingeot-Leclercq, R F M de Almeida, L C Silva
Nystatin (Nys) is a pore forming broad-spectrum and efficient antifungal drug with significant toxicity in mammalian organisms. In order to develop a non-toxic and more effective Nys formulation, its molecular mechanism of action at the cell membrane needs to be better understood. It is widely accepted that Nys activity and toxicity depend on the presence and type of membrane sterols. Taking advantage of multiple biophysical methodologies, we now show that the formation and stabilization of Nys aqueous pores, which are associated with Nys cytotoxicity, occur in the absence of membrane sterols...
November 3, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29063477/easy-fast-and-reproducible-quantification-of-cholesterol-and-other-lipids-in-human-plasma-by-combined-high-resolution-msx-and-ftms-analysis
#5
Sandra F Gallego, Kurt Højlund, Christer S Ejsing
Reliable, cost-effective, and gold-standard absolute quantification of non-esterified cholesterol in human plasma is of paramount importance in clinical lipidomics and for the monitoring of metabolic health. Here, we compared the performance of three mass spectrometric approaches available for direct detection and quantification of cholesterol in extracts of human plasma. These approaches are high resolution full scan Fourier transform mass spectrometry (FTMS) analysis, parallel reaction monitoring (PRM), and novel multiplexed MS/MS (MSX) technology, where fragments from selected precursor ions are detected simultaneously...
October 23, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29053478/%C3%AE-lipoic-acid-as-adjunctive-treatment-for-schizophrenia-an-open-label-trial
#6
Lia Lira Olivier Sanders, Carlos Eduardo de Souza Menezes, Adriano José Maia Chaves Filho, Glautemberg de Almeida Viana, Francisco Vagnaldo Fechine, Maria Goretti Rodrigues de Queiroz, Said Gonçalvez da Cruz Fonseca, Silvânia Maria Mendes Vasconcelos, Maria Elisabete Amaral de Moraes, Clarissa S Gama, Sheila Seybolt, Eugênio de Moura Campos, Danielle Macêdo, David Freitas de Lucena
PURPOSE/BACKGROUND: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae. α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy. METHODS/PROCEDURES: In this pilot investigation, we administered ALA (100 mg/d) for 4 months, as an adjunct to antipsychotic medication, to 10 patients with schizophrenia...
October 19, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29046732/effect-of-a-diet-containing-folate-and-hazelnut-oil-capsule-on-the-methylation-level-of-the-adrb3-gene-lipid-profile-and-oxidative-stress-in-overweight-or-obese-women
#7
Raquel Patrícia Ataíde Lima, Rayner Anderson Ferreira do Nascimento, Rafaella Cristhine Pordeus Luna, Darlene Camati Persuhn, Alexandre Sérgio da Silva, Maria da Conceição Rodrigues Gonçalves, Alessio Tony Cavalcanti de Almeida, Ronei Marcos de Moraes, Eliseu Verly Junior, Emmanuelle Fouilloux-Meugnier, Hubert Vidal, Luciano Pirola, Marciane Magnani, Naila Francis Paulo de Oliveira, Patrícia Oliveira Prada, Maria José de Carvalho Costa
BACKGROUND: Studies of genes that play an important role in the development of obesity are needed, especially studies focusing on genes that regulate food intake and affect nutrient metabolism. For example, the beta-3 adrenergic receptor (ADRB3) responds to noradrenaline and mediates lipolysis in adipocytes. METHODS: This was a controlled intervention study involving 40 overweight and obese adult women in which food intake, anthropometric measurements, biochemical analyses, and methylation levels of the ADRB3 gene were evaluated before and after intervention...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29042181/opposing-roles-of-pgd2-in-gbm
#8
Matthew Thomas Ferreira, Renata Nascimento Gomes, Alexandros Theodoros Panagopoulos, Fernando Gonçalves de Almeida, José Carlos Esteves Veiga, Alison Colquhoun
BACKGROUND: The World Health Organization classifies glioblastoma (GBM) as a grade IV astrocytoma. Despite the advances in chemotherapy, surgery, and radiation treatments that improve a patient's length of survival, the overall trajectory of the disease remains unchanged. GBM cells produce significant levels of various types of bioactive lipids. Prostaglandin D2 (PGD2) influences both pro- and anti-tumorigenic activities in the cell; however, its role in GBM is unclear. Therefore, this study aimed to identify the impact of PGD2 on GBM cell activities in vitro...
October 16, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28993269/hydrogen-peroxide-resistance-in-strigomonas-culicis-effects-on-mitochondrial-functionality-and-aedes-aegypti-interaction
#9
Ana Cristina Souza Bombaça, Felipe de Almeida Dias, Vitor Ennes-Vidal, Aline Dos Santos Garcia-Gomes, Marcos Henrique Ferreira Sorgine, Claudia Masini d'Avila-Levy, Rubem Figueiredo Sadok Menna-Barreto
Reactive oxygen species (ROS) are toxic molecules involved in several biological processes such as cellular signaling, proliferation, differentiation and cell death. Adaptations to oxidative environments are crucial for the success of the colonization of insects by protozoa. Strigomonas culicis is a monoxenic trypanosomatid found in the midgut of mosquitoes and presenting a life cycle restricted to the epimastigote form. Among S. culicis peculiarities, there is an endosymbiotic bacterium in the cytoplasm, which completes essential biosynthetic routes of the host cell and may represent an intermediary evolutive step in organelle origin, thus constituting an interesting model for evolutive researches...
October 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28990534/association-between-vitamin-d-status-oxidative-stress-biomarkers-and-viral-load-in-human-immunodeficiency-virus-type-1-infection
#10
Tamires Flauzino, Andréa Nc Simão, Elaine Rd de Almeida, Helena K Morimoto, Sayonara R Oliveira, Daniela F Alfieri, Luiz T Ueda, Isaias Dichi, Edna Mv Reiche
BACKGROUND: The role of vitamin D in the pathophysiology of human immunodeficiency virus type 1 (HIV-1) infection is still unclear. OBJECTIVE: To evaluate the associations between vitamin D and immunological, virological, and oxidative stress biomarkers in individuals with human immunodeficiency virus type 1 (HIV-1) infection. METHODS: The serum levels of 25 hydroxyvitamin D [25(OH)D] were determined in 314 HIV-1-infected individuals and 127 controls and the values ≥30 ng/mL defined a vitamin D sufficient (VDS) status, and <30 ng/mL defined as hypovitaminosis D (HD)...
October 5, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28988557/effects-of-dietary-inclusion-of-citrus-pulp-and-rockrose-soft-stems-and-leaves-on-lamb-meat-quality-and-fatty-acid-composition
#11
A Francisco, S P Alves, P V Portugal, M T Dentinho, E Jerónimo, S Sengo, J Almeida, M C Bressan, V M R Pires, C M Alfaia, J A M Prates, R J B Bessa, J Santos-Silva
Meat from lambs finished with high-starch diets often contains low concentration of vaccenic (t11-18:1) and rumenic (c9,t11-18:2) acids and high concentration of t10-18:1. We hypothesized that replacing cereals by dehydrated citrus pulp (DCP) and the inclusion of tanniferous feed sources in oil supplemented diets might reduce the accumulation of t10-18:1 and increase the t11-18:1 and c9,t11-18:2 in lamb meat, without affecting the productive performance. In total, 32 lambs were assigned to four diets which combine two factors: basal diet (BD) (cereals v...
October 9, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28940978/effects-of-short-term-add-on-ezetimibe-to-statin-treatment-on-expression-of-adipokines-and-inflammatory-markers-in-diabetic-and-dyslipidemic-patients
#12
Elizandra Silva Guimarães, Alvaro Cerda, Egidio Lima Dorea, Marcia Martins Silveira Bernik, Maria Cecilia Gusukuma, Gelba Almeida Pinto, Cristina Moreno Fajardo, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata
AIM: The influence of short-term add-on ezetimibe to simvastatin treatment on expression of adipokines and inflammatory markers was investigated in diabetic and nondiabetic patients with hypercholesterolemia. METHOD: Hypercholesterolemic nondiabetic (HC, n = 37) and diabetic (DM, n = 47) patients were treated with simvastatin (SV, 10 or 20 mg/d/8-wk) and then SV plus ezetimibe (SV + EZ, 10 mg each/d/4 wk). Serum lipids, glycemic profile, and inflammatory markers (hsCRP, adiponectin, resistin, VCAM-1, and ICAM-1) were evaluated before and after the add-on ezetimibe therapy...
September 21, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28892741/effect-of-diet-with-omega-3-in-basal-brain-electrical-activity-and-during-status-epilepticus-in-rats
#13
Daniella Tavares Pessoa, Eva Luana Almeida da Silva, Edbhergue Ventura Lola Costa, Romildo Albuquerque Nogueira
Western diets are high in saturated fat and low in omega-3. Certain animals cannot produce omega-3 from their own lipids, making it necessary for it to be acquired from the diet. However, omega-3s are important components of the plasma membrane, and altering their proportions can promote physical and chemical alterations in the membranes, which may modify neuronal excitability. These alterations occur in healthy individuals, as well as in patients with epilepsy who are more sensitive to changes in brain electrical activity...
September 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28881179/correlation-of-body-mass-index-z-scores-with-glucose-and-lipid-profiles-among-overweight-and-obese-children-and-adolescents
#14
Carlos Alberto Nogueira-de-Almeida, Elza Daniel de Mello
OBJECTIVE: To evaluate the prevalence of abnormalities in plasma lipid and glucose profiles among overweight and obese children and adolescents, and to assess the presence of a correlation between body mass index Z-scores and indicators of comorbidities related to both profiles. METHODS: This was a multicenter cross-sectional study conducted at two outpatient clinics. The study included all 417 comers for the first visit from 2008 to 2012, aged between 7 and 18 years, with BMI above the Z-score +1...
September 4, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28876386/a-possible-relationship-between-gluconeogenesis-and-glycogen-metabolism-in-rabbits-during-myocardial-ischemia
#15
Raquel R DE Aguiar, Daniela F Vale, Renato M DA Silva, Yolanda P Muniz, Fernanda Antunes, Carlos Logullo, André L A Oliveira, Adriana J DE Almeida
Ischemia is responsible for many metabolic abnormalities in the heart, causing changes in organ function. One of modifications occurring in the ischemic cell is changing from aerobic to anaerobic metabolism. This change causes the predominance of the use of carbohydrates as an energy substrate instead of lipids. In this case, the glycogen is essential to the maintenance of heart energy intake, being an important reserve to resist the stress caused by hypoxia, using glycolysis and lactic acid fermentation. In order to study the glucose anaerobic pathways utilization and understand the metabolic adaptations, New Zealand white rabbits were subjected to ischemia caused by Inflow occlusion technique...
July 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28866224/highlights-in-nanocarriers-for-the-treatment-against-cervical-cancer
#16
REVIEW
Kaila P Medina-Alarcón, Aline R Voltan, Bruno Fonseca-Santos, Isabela Jacob Moro, Felipe de Oliveira Souza, Marlus Chorilli, Christiane Pienna Soares, André Gonzaga Dos Santos, Maria J S Mendes-Giannini, Ana M Fusco-Almeida
Cervical cancer is the second most common malignant tumor in women worldwide and has a high mortality rate, especially when it is associated with human papillomavirus (HPV). In US, an estimated 12,820 cases of invasive cervical cancer and an estimated 4210 deaths from this cancer will occur in 2017. With rare and very aggressive conventional treatments, one sees in the real need of new alternatives of therapy as the delivery of chemotherapeutic agents by nanocarriers using nanotechnology. This review covers different drug delivery systems applied in the treatment of cervical cancer, such as solid lipid nanoparticles (SNLs), liposomes, nanoemulsions and polymeric nanoparticles (PNPs)...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28831063/sterol-targeting-drugs-reveal-life-cycle-stage-specific-differences-in-trypanosome-lipid-rafts
#17
Aabha I Sharma, Cheryl L Olson, João I Mamede, Felipe Gazos-Lopes, Conrad L Epting, Igor C Almeida, David M Engman
Cilia play important roles in cell signaling, facilitated by the unique lipid environment of a ciliary membrane containing high concentrations of sterol-rich lipid rafts. The African trypanosome Trypanosoma brucei is a single-celled eukaryote with a single cilium/flagellum. We tested whether flagellar sterol enrichment results from selective flagellar partitioning of specific sterol species or from general enrichment of all sterols. While all sterols are enriched in the flagellum, cholesterol is especially enriched...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814977/worse-inflammatory-profile-in-omnivores-than-in-vegetarians-associates-with-the-gut-microbiota-composition
#18
Ana Carolina Franco-de-Moraes, Bianca de Almeida-Pititto, Gabriel da Rocha Fernandes, Everton Padilha Gomes, Alexandre da Costa Pereira, Sandra Roberta G Ferreira
AIMS: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile. METHODS: A total of 268 non-diabetic individuals were stratified into groups of dietary types (strict vegetarians, lacto-ovo-vegetarians, and omnivores). The taxonomic composition and phylogenetic structure of the microbiota were obtained through the analysis of the 16S rRNA gene...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28809501/microencapsulated-solid-lipid-nanoparticles-as-a-hybrid-platform-for-pulmonary-antibiotic-delivery
#19
Diana P Gaspar, Maria Manuela Gaspar, Carla V Eleutério, Ana Grenha, Mateo Blanco, Lídia M D Gonçalves, Pablo Taboada, António J Almeida, Carmen Remuñán-López
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate their pulmonary delivery, the RFB-loaded SLN were included in microspheres of appropriate size using suitable excipients (mannitol and trehalose) through a spray-drying technique. Confocal analysis microscopy showed that microspheres are spherical and that SLN are efficiently microencapsulated and homogeneously distributed throughout the microsphere matrices...
August 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28805916/the-reduction-of-starch-in-finishing-diets-supplemented-with-oil-does-not-prevent-the-accumulation-of-trans-10-18-1-in-lamb-meat
#20
M Costa, S P Alves, A Francisco, J Almeida, C M Alfaia, S V Martins, J A M Prates, J Santos-Silva, O Doran, R J B Bessa
The experiment was conducted to test the hypothesis that the replacement of cereal with low-starch feed ingredients in lambs' finishing diets supplemented with oils could prevent the accumulation of -10-18:1 in meat. Forty lambs were fed 1 of 4 diets supplemented with soybean oil (5.9%) and fish oil (1%) for 6 wk before slaughter. The control (CON) diet contained 43% barley, and in the other diets, barley was completely replaced by dehydrated citrus pulp (DCP), dehydrated sugar beet pulp (DBP), or soybean hulls (SH)...
August 2017: Journal of Animal Science
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