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https://www.readbyqxmd.com/read/29773003/antioxidant-action-of-an-aqueous-extract-of-royal-sun-medicinal-mushroom-agaricus-brasiliensis-agaricomycetes-in-rats-with-adjuvant-induced-arthritis
#1
Aline Cristine da Silva de Souza, Geferson de Almeida Gonсalves, Andréia Assunсão Soares, Anacharis B de Sá-Nakanishi, Ana Paula de Santi-Rampazzo, Maria Raquel Marсal Natali, Rosane Marina Peralta, Adelar Bracht
The purpose of this study was to evaluate possible effects of the administration of an aqueous Agaricus brasiliensis extract on the oxidative state of the liver, brain, and plasma in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Daily doses of 400 mg · kg-1 were administered by gavage for 23 days. This treatment produced significant diminutions in protein carbonylation and lipid damage in the liver, brain, and plasma. It also diminished the tissue reactive oxygen species and increased the antioxidant capacity of the plasma...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29753828/physiological-ultrastructural-biochemical-and-molecular-responses-of-young-cocoa-plants-to-the-toxicity-of-cr-iii-in-soil
#2
Junea Leandro do Nascimento, Alex-Alan Furtado de Almeida, Joedson P Barroso, Pedro A O Mangabeira, Dário Ahnert, Artur G R Sousa, José Vitor S Silva, Virupax C Baligar
The objective of this study was to evaluate Cr toxicity in young plants of the CCN 51 Theobroma cacao genotype at different concentrations of Cr3+ in the soil (0, 100, 200, 400 and 600 mg kg-1 ) through physiological, ultrastructural, antioxidant and molecular changes. Doses of 400 and 600 mg Cr3+ kg-1 soil severely affected foliar gas exchange, promoted by damages in photosynthetic machinery evidenced by the decrease in CO2 fixation. Decreased expression of psbA and psbO genes, changes in enzymatic activity and lipid peroxidation also affected leaf gas exchange...
May 10, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29746894/sphingolipid-hydroxylation-in-mammals-yeast-and-plants-an-integrated-view
#3
REVIEW
Joaquim Trigo Marquês, H Susana Marinho, Rodrigo Freire Martins de Almeida
This review is focused on sphingolipid backbone hydroxylation, a small but widespread structural feature, with profound impact on membrane biophysical properties. We start by summarizing sphingolipid metabolism in mammalian cells, yeast and plants, focusing on how distinct hydroxylation patterns emerge in different eukaryotic kingdoms. Then, a comparison of the biophysical properties in membrane model systems and cellular membranes from diverse organisms is made. From an integrative perspective, these results can be rationalized considering that superficial hydroxyl groups in the backbone of sphingolipids (by intervening in the H-bond network) alter the balance of favorable interactions between membrane lipids...
May 7, 2018: Progress in Lipid Research
https://www.readbyqxmd.com/read/29716762/plasma-zinc-in-institutionalized-elderly-individuals-relation-with-immune-and-cardiometabolic-biomarkers
#4
Márcia Cristina Sales, Larissa Praça de Oliveira, Natalia Louise de Araújo Cabral, Sara Estéfani Soares de Sousa, Maria das Graças Almeida, Telma Maria Araújo Moura Lemos, Clélia de Oliveira Lyra, Kenio Costa de Lima, Karine Cavalcanti Mauricio Sena-Evangelista, Lucia de Fatima Campos Pedrosa
Changes in zinc metabolism caused by aging and the institutionalization process may contribute to zinc deficiency in elderly individuals. Hypozincemia results in changes in glycemic, lipid, and inflammatory profiles. The aim of this study was to evaluate plasma zinc concentrations and their relationships with sociodemographic, dietary, inflammatory, and cardiometabolic biomarkers in institutionalized elderly individuals. A cross-sectional study was carried out including 255 elderly adults living in nursing homes...
April 24, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29714196/effects-of-soft-x-ray-radiation-damage-on-paraffin-embedded-rat-tissues-supported-on-ultralene-a-chemical-perspective
#5
Diana E Bedolla, Andrea Mantuano, Arissa Pickler, Carla Lemos Mota, Delson Braz, Camila Salata, Carlos Eduardo Almeida, Giovanni Birarda, Lisa Vaccari, Regina Cély Barroso, Alessandra Gianoncelli
Radiation damage is an important aspect to be considered when analysing biological samples with X-ray techniques as it can induce chemical and structural changes in the specimens. This work aims to provide new insights into the soft X-ray induced radiation damage of the complete sample, including not only the biological tissue itself but also the substrate and embedding medium, and the tissue fixation procedure. Sample preparation and handling involves an unavoidable interaction with the sample matrix and could play an important role in the radiation-damage mechanism...
May 1, 2018: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/29704049/extrafloral-nectaries-of-four-varieties-of-chamaecrista-ramosa-vogel-h-s-irwin-barneby-fabaceae-anatomy-chemical-nature-mechanisms-of-nectar-secretion-and-elimination
#6
Priscila da Silva Pereira, Letícia de Almeida Golçalves, Marcos José da Silva, Maria Helena Rezende
Considering the importance of extrafloral nectaries (EFNs) in Fabaceae, the objectives of this research were to analyze (1) the anatomical and histochemical characteristics of the EFNs of Chamaecrista ramosa var. ramosa, C. ramosa var. curvifoliola, C. ramosa var. parvifoliola, and C. ramosa var. lucida and (2) the ultrastructure of the EFNs of C. ramosa var. ramosa. Standard techniques in plant anatomy and transmission electron microscopy were used. The anatomical analyses confirmed the characteristics described for extrafloral nectaries, evidencing three well-defined regions: epidermis, nectariferous, and subnectariferous parenchymas...
April 27, 2018: Protoplasma
https://www.readbyqxmd.com/read/29663868/imaging-mass-spectrometry-of-endogenous-polypeptides-and-secondary-metabolites-from-galls-induced-by-root-knot-nematodes-in-tomato-roots
#7
Eder Alves Barbosa, Mauro Ferreira Bonfim Junior, Carlos Bloch, Thales Lima Rocha, Gilbert Engler, Janice de Almeida Engler
Nematodes are devastating pests that infect most cultivated plant species and cause considerable agricultural losses worldwide. The understanding of metabolic adjustments induced during plant-nematode interaction is crucial to generate resistant plants or to select more efficient molecules to fight against this pest. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been used herein for in situ detection and mapping endogenous polypeptides and secondary metabolites from nematode-induced gall tissue...
April 17, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29661450/effect-of-hepatic-preconditioning-with-the-use-of-methylene-blue-on-the-liver-of-wistar-rats-submitted-to-ischemia-and-reperfusion
#8
T N de Almeida, J P Victorino, J Bistafa Liu, D Tófoli Queiroz Campos, C Graf, M C Jordani, L A Carneiro d'Albuquerque, K D S Mendes, O Castro-E-Silva
BACKGROUND: The liver may be injured in situations where it is submitted to ischemia, such as partial hepatectomy and liver transplantation. In all cases, ischemia is followed by reperfusion and, although it is essential for the reestablishment of tissue function, reperfusion may cause greater damage than ischemia, an injury characterized as ischemia-reperfusion (I/R) damage. The aim of this work was to analyze the effect of ischemic preconditioning with the use of methylene blue (MB; 15 mg/kg) 5 or 15 minutes before I/R (IRMB5' and IRMB15', respectively) on the hepatic injury occurring after I/R...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29643852/innate-immune-responses-in-leprosy
#9
REVIEW
Roberta Olmo Pinheiro, Veronica Schmitz, Bruno Jorge de Andrade Silva, André Alves Dias, Beatriz Junqueira de Souza, Mayara Garcia de Mattos Barbosa, Danuza de Almeida Esquenazi, Maria Cristina Vidal Pessolani, Euzenir Nunes Sarno
Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae . Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29626799/lipid-reducing-activity-and-toxicity-profiles-of-a-library-of-polyphenol-derivatives
#10
Ralph Urbatzka, Sara Freitas, Andreia Palmeira, Tiago Almeida, João Moreira, Carlos Azevedo, Carlos Afonso, Marta Correia-da-Silva, Emilia Sousa, Madalena Pinto, Vitor Vasconcelos
Obesity is an increasing epidemic worldwide and novel treatments are urgently needed. Polyphenols are natural compounds derived from plants, which are known in particular for their antioxidant properties. However, some polyphenols were described to possess anti-obesity activities in vitro and in vivo. In this study, we aimed to screen a library of 85 polyphenol derivatives for their lipid reducing activity and toxicity. Compounds were analyzed at 5 μM with the zebrafish Nile red fluorescence fat metabolism assay and for general toxicity in vivo...
March 23, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29624716/oral-juvenile-xanthogranuloma-in-a-child-clinical-histological-and-immunohistochemical-profile-of-a-rare-entity
#11
Celeste Sánchez-Romero, Ana Isabel Cuenca Arriaga, Oslei Paes de Almeida, Evangelina Gutiérrez Cortés
Juvenile Xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis (non-LCH) affecting normolipemic infants and children most frequently in the first year of life, often showing spontaneous regression within 3 to 6 years. Classic JXG is characterized by a yellowish asymptomatic papule or nodule, often located in the skin of the head, neck and upper trunk. Oral JXG have been reported, but is rare. Histologically JXG is composed mainly by an infiltrate of macrophages with a variable degree of lipidization (foamy macrophages), and (most of the times) scattered Touton type giant cells...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29621135/applying-fourier-transform-mid-infrared-spectroscopy-to-detect-the-adulteration-of-salmo-salar-with-oncorhynchus-mykiss
#12
Nuno Sousa, Maria João Moreira, Cristina Saraiva, José M M M de Almeida
The aim of this study was to evaluate the potential of Fourier transform infrared (FTIR) spectroscopy coupled with chemometric methods to detect fish adulteration. Muscles of Atlantic salmon ( Salmo salar ) (SS) and Salmon trout ( Onconrhynchus mykiss ) (OM) muscles were mixed in different percentages and transformed into mini-burgers. These were stored at 3 °C, then examined at 0, 72, 160, and 240 h for deteriorative microorganisms. Mini-burgers was submitted to Soxhlet extraction, following which lipid extracts were analyzed by FTIR...
April 5, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29616011/lipid-bodies-as-sites-of-prostaglandin-e2-synthesis-during-chagas-disease-impact-in-the-parasite-escape-mechanism
#13
REVIEW
Patrícia E de Almeida, Daniel A M Toledo, Gabriel S C Rodrigues, Heloisa D'Avila
During Chagas disease, the Trypanosoma cruzi can induce some changes in the host cells in order to escape or manipulate the host immune response. The modulation of the lipid metabolism in the host phagocytes or in the parasite itself is one feature that has been observed. The goal of this mini review is to discuss the mechanisms that regulate intracellular lipid body (LB) biogenesis in the course of this parasite infection and their meaning to the pathophysiology of the disease. The interaction host-parasite induces LB (or lipid droplet) formation in a Toll-like receptor 2-dependent mechanism in macrophages and is enhanced by apoptotic cell uptake...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29603643/skeletal-optimization-of-antitumor-lipidic-dialkynylcarbinols
#14
Maroua Bourkhis, Hafida Gaspard, Pauline Rullière, Diana K C de Almeida, Dymytrii Listunov, Etienne Joly, Raoudha Abderrahim, Marcos C de Mattos, Maria C F de Oliveira, Valérie Maraval, Remi Chauvin, Yves Genisson
In line with our study of the pharmacological potential of bio-inspired synthetic acetylenic lipids, this work specifically addresses the issue of the carbon backbone length. Focusing on two representative chiral alkynylcarbinol pharmacophores, a systematic variation of the aliphatic chain was carried out. The critical impact of the length of the lipidic skeleton was first confirmed in racemic series with the strongest cytotoxic activity for C17 to C18 backbones. Enantiomerically enriched compounds were prepared by asymmetric synthesis for the optimal C18 dialkynylcarbinol (DAC) and C17 butadiynylcarbinol (BAC) derivatives...
March 30, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29572072/effects-of-isopentyl-ferulate-on-oxidative-stress-biomarkers-and-a-possible-gabaergic-anxiolytic-like-trait-in-swiss-mice
#15
Keylla da Conceição Machado, George Layson da Silva Oliveira, Md Torequl Islam, Antonia Amanda Cardoso de Almeida, Damião Pergentino de Sousa, Ana Amélia de Carvalho Melo Cavalcante, Rivelilson Mendes de Freitas
This study aimed to evaluate the anxiolytic-like effect and the possible neuronal mechanism of action of isopentyl ferulate (IF). For this purpose, we used the marble burying test in Swiss albino mice. The biomarkers involved in oxidative stress were measured in the hippocampus homogenate of the test animals. In addition, the toxicity and antioxidant capacities were tested in Artemia salina and rat erythrocytes, respectively. The results suggest that, an acute administration of the IF at doses of 25, 50, 75 and 150 mg/kg (intraperitoneal, i...
March 20, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29567541/epiisopiloturine-an-imidazole-alkaloid-reverses-inflammation-and-lipid-peroxidation-parameters-in-the-crohn-disease-model-induced-by-trinitrobenzenosulfonic-acid-in-wistar-rats
#16
Lucas Rodrigues de Carvalho, Tarcisio Vieira de Brito, José Simião da C Júnior, Genilson José Dias Júnior, Diva de Aguiar Magalhãres, Stefany Guimarães Sousa, Renan Oliveira Silva, Felipe Rodolfo Pereira da Silva, Daniel Fernando Pereira Vasconcelos, Leiz Maria Costa Véras, José Roberto de Sousa de Almeida Leite, Dainesy Santos Martins, Conceição da Silva Martins, Jefferson Soares de Oliveira, André Luiz Dos Reis Barbosa
Epiisopiloturine (EPI) is an important imidazole alkaloid because of its pharmacological properties. The aim of this study was to investigate the effects of epiisopiloturine on inflammatory parameters of the colonic mucosa in a rat model of Crohn's disease (CD). For this, we induced colitis using trinitrobenzenosulfonic acid and determined myeloperoxidase (MPO), interleukin 1 β (IL-1β), glutathione (GSH), and malondialdehyde (MDA) levels in the intestinal mucosa. The location and expression of the inflammatory markers in the colon were investigated by immunohistochemistry for NO synthase induced (iNOS), interleukin 1 beta (IL-1β), and cyclooxygenase-2 (COX-2) and western blotting (iNOS and COX-2), respectively...
March 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29555360/development-of-a-partitioned-liquid-liquid-extraction-dispersive-solid-phase-extraction-procedure-followed-by-liquid-chromatography-tandem-mass-spectrometry-for-analysis-of-3-monochloropropane-1-2-diol-diesters-in-edible-oils
#17
J A Custodio-Mendoza, R A Lorenzo, I M Valente, P J Almeida, M A Lage, J A Rodrigues, A M Carro
A fast and effective method using a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) approach which includes partitioned liquid-liquid extraction (PLLE) and dispersive solid phase extraction (dSPE) clean-up step for the determination of seven 3-monochloropropane-1,2-diol (3-MCPD) fatty acid diesters in vegetable oils is developed and validated according to the Food and Drug Administration (FDA) guidelines. Due to the complexity of the matrices, combination of silica based sorbents (Silica Strong Anion Exchange (Si-SAX), Supel™ QuE Z-Sep+ (Z-Sep+) and Primary Secondary Amine (PSA) were tested for lipid removal...
March 13, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29520624/maternal-soybean-diet-during-lactation-alters-breast-milk-composition-and-programs-the-lipid-profile-in-adult-male-rat-offspring
#18
Adriana Moura Vieira, Poliana Guiomar de Almeida Brasiel, Maíra Schuchter Ferreira, Kacia Mateus, Mariana Sarto Figueiredo, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, José Otavio do Amaral Corrêa, Fernando Cesar Ferraz Lopes, Paulo Henrique Fonseca da Silva, Céphora Maria Sabarense, Sheila Cristina Potente Luquetti Dutra, Aline Silva de Aguiar
PURPOSE: To evaluate the effects of maternal dietary soybean during lactation on the milk composition, body composition, lipid profile and glucose homeostasis of dams and offspring at weaning (21 days) and adulthood (150 days). METHODS: Lactating rats were divided into: casein control (C): casein diet; soy (S): soybean diet; soy oil control (SOC): casein diet, but with fat content similar to the S group. RESULTS: At 21 days, S mothers showed lower estradiol, total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglycerides (TG) in serum; and lower TC and TG in milk...
May 2018: Endocrine
https://www.readbyqxmd.com/read/29501945/a-novel-synthetic-peptide-inspired-on-lys49-phospholipase-a-2-from-crotalus-oreganus-abyssus-snake-venom-active-against-multidrug-resistant-clinical-isolates
#19
José R Almeida, Bruno Mendes, Marcelo Lancellotti, Sergio Marangoni, Nuno Vale, Óscar Passos, Maria J Ramos, Pedro A Fernandes, Paula Gomes, Saulo L Da Silva
Currently, the evolving and complex mechanisms of bacterial resistance to conventional antibiotics are increasing, while alternative medicines are drying up, which urges the need to discover novel agents able to kill antibiotic-resistant bacteria. Lys49 phospholipase A2 s (PLA2 s) from snake venoms are multifunctional toxins able to induce a huge variety of therapeutic effects and consequently serve as templates for new drug leads. Hence, the present study was aimed at the synthesis of oligopeptides mimicking regions of the antibacterial Lys49 PLA2 toxin (CoaTx-II), recently isolated from Crotalus oreganus abyssus snake venom, to identify small peptides able to reproduce the therapeutic action of the toxin...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29494826/effects-of-single-and-combined-exposure-of-pharmaceutical-drugs-carbamazepine-and-cetirizine-and-a-metal-cadmium-on-the-biochemical-responses-of-r-philippinarum
#20
Ângela Almeida, Vânia Calisto, Valdemar I Esteves, Rudolf J Schneider, Amadeu M V M Soares, Etelvina Figueira, Rosa Freitas
In the aquatic environment, organisms are exposed to complex mixtures of contaminants which may alter the toxicity profile of each compound, compared to its toxicity alone. Pharmaceutical drugs (e.g. carbamazepine (CBZ) and cetirizine (CTZ)) and metals (e.g. cadmium (Cd)) are among those contaminants that co-occur in the environment. However, most studies concerning their toxicity towards aquatic species are based on single exposure experiments. Thus, the present study aimed to evaluate single and combined effects of Cd and CBZ or CTZ (single conditions: Cd, CTZ, CBZ; combined conditions: CTZ + Cd, CBZ + Cd) on biomarkers related to oxidative stress and energy metabolism in the edible clam Ruditapes philippinarum, by exposing the organisms for 28 days to environmentally relevant concentrations of these contaminants...
May 2018: Aquatic Toxicology
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