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https://www.readbyqxmd.com/read/28892741/effect-of-diet-with-omega-3-in-basal-brain-electrical-activity-and-during-status-epilepticus-in-rats
#1
Daniella Tavares Pessoa, Eva Luana Almeida da Silva, Edbhergue Ventura Lola Costa, Romildo Albuquerque Nogueira
Western diets are high in saturated fat and low in omega-3. Certain animals cannot produce omega-3 from their own lipids, making it necessary for it to be acquired from the diet. However, omega-3s are important components of the plasma membrane, and altering their proportions can promote physical and chemical alterations in the membranes, which may modify neuronal excitability. These alterations occur in healthy individuals, as well as in patients with epilepsy who are more sensitive to changes in brain electrical activity...
September 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28881179/correlation-of-bmi-z-scores-with-glucose-and-lipid-profiles-among-overweight-and-obese-children-and-adolescents
#2
Carlos Alberto Nogueira-de-Almeida, Elza Daniel de Mello
OBJECTIVE: To evaluate the prevalence of abnormalities in plasma lipid and glucose profiles among overweight and obese children and adolescents, and to assess the presence of a correlation between BMI Z-scores and indicators of comorbidities related to both profiles. METHODS: This was a multicenter cross-sectional study conducted at two outpatient clinics. The study included all 417 comers for the first visit from 2008 to 2012, aged between 7 and 18 years, with BMI above the Z-score +1...
September 4, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28876386/a-possible-relationship-between-gluconeogenesis-and-glycogen-metabolism-in-rabbits-during-myocardial-ischemia
#3
Raquel R DE Aguiar, Daniela F Vale, Renato M DA Silva, Yolanda P Muniz, Fernanda Antunes, Carlos Logullo, André L A Oliveira, Adriana J DE Almeida
Ischemia is responsible for many metabolic abnormalities in the heart, causing changes in organ function. One of modifications occurring in the ischemic cell is changing from aerobic to anaerobic metabolism. This change causes the predominance of the use of carbohydrates as an energy substrate instead of lipids. In this case, the glycogen is essential to the maintenance of heart energy intake, being an important reserve to resist the stress caused by hypoxia, using glycolysis and lactic acid fermentation. In order to study the glucose anaerobic pathways utilization and understand the metabolic adaptations, New Zealand white rabbits were subjected to ischemia caused by Inflow occlusion technique...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28866224/highlights-in-nanocarriers-for-the-treatment-against-cervical-cancer
#4
REVIEW
Kaila P Medina-Alarcón, Aline R Voltan, Bruno Fonseca-Santos, Isabela Jacob Moro, Felipe de Oliveira Souza, Marlus Chorilli, Christiane Pienna Soares, André Gonzaga Dos Santos, Maria J S Mendes-Giannini, Ana M Fusco-Almeida
Cervical cancer is the second most common malignant tumor in women worldwide and has a high mortality rate, especially when it is associated with human papillomavirus (HPV). In US, an estimated 12,820 cases of invasive cervical cancer and an estimated 4210 deaths from this cancer will occur in 2017. With rare and very aggressive conventional treatments, one sees in the real need of new alternatives of therapy as the delivery of chemotherapeutic agents by nanocarriers using nanotechnology. This review covers different drug delivery systems applied in the treatment of cervical cancer, such as solid lipid nanoparticles (SNLs), liposomes, nanoemulsions and polymeric nanoparticles (PNPs)...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28831063/sterol-targeting-drugs-reveal-life-cycle-stage-specific-differences-in-trypanosome-lipid-rafts
#5
Aabha I Sharma, Cheryl L Olson, João I Mamede, Felipe Gazos-Lopes, Conrad L Epting, Igor C Almeida, David M Engman
Cilia play important roles in cell signaling, facilitated by the unique lipid environment of a ciliary membrane containing high concentrations of sterol-rich lipid rafts. The African trypanosome Trypanosoma brucei is a single-celled eukaryote with a single cilium/flagellum. We tested whether flagellar sterol enrichment results from selective flagellar partitioning of specific sterol species or from general enrichment of all sterols. While all sterols are enriched in the flagellum, cholesterol is especially enriched...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814977/worse-inflammatory-profile-in-omnivores-than-in-vegetarians-associates-with-the-gut-microbiota-composition
#6
Ana Carolina Franco-de-Moraes, Bianca de Almeida-Pititto, Gabriel da Rocha Fernandes, Everton Padilha Gomes, Alexandre da Costa Pereira, Sandra Roberta G Ferreira
AIMS: To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardiovascular risk profile. METHODS: A total of 268 non-diabetic individuals were stratified into groups of dietary types (strict vegetarians, lacto-ovo-vegetarians, and omnivores). The taxonomic composition and phylogenetic structure of the microbiota were obtained through the analysis of the 16S rRNA gene...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28809501/microencapsulated-solid-lipid-nanoparticles-as-a-hybrid-platform-for-pulmonary-antibiotic-delivery
#7
Diana P Gaspar, Maria Manuela Gaspar, Carla V Eleutério, Ana Grenha, Mateo Blanco, Lídia M D Gonçalves, Pablo Taboada, António J Almeida, Carmen Remuñán-López
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate their pulmonary delivery, the RFB-loaded SLN were included in microspheres of appropriate size using suitable excipients (mannitol and trehalose) through a spray-drying technique. Confocal analysis microscopy showed that microspheres are spherical and that SLN are efficiently microencapsulated and homogeneously distributed throughout the microsphere matrices...
August 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28805916/the-reduction-of-starch-in-finishing-diets-supplemented-with-oil-does-not-prevent-the-accumulation-of-trans-10-18-1-in-lamb-meat
#8
M Costa, S P Alves, A Francisco, J Almeida, C M Alfaia, S V Martins, J A M Prates, J Santos-Silva, O Doran, R J B Bessa
The experiment was conducted to test the hypothesis that the replacement of cereal with low-starch feed ingredients in lambs' finishing diets supplemented with oils could prevent the accumulation of -10-18:1 in meat. Forty lambs were fed 1 of 4 diets supplemented with soybean oil (5.9%) and fish oil (1%) for 6 wk before slaughter. The control (CON) diet contained 43% barley, and in the other diets, barley was completely replaced by dehydrated citrus pulp (DCP), dehydrated sugar beet pulp (DBP), or soybean hulls (SH)...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28767993/physical-activity-in-brazil-lessons-from-elsa-brasil-narrative-review
#9
Francisco José Gondim Pitanga, Maria Conceição Chagas Almeida, Ciro Oliveira Queiroz, Estela Maria Leão de Aquino, Sheila Maria Alvim Matos
CONTEXT AND OBJECTIVE: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) was conducted among civil servants at six higher education institutions located in six Brazilian state capitals. The objective of this review was to identify the publications produced within the scope of ELSA-Brasil that analyzed the participants' physical activity. DESIGN AND SETTING: Review study using baseline data from ELSA-Brasil. METHODS: Narrative review of Brazilian studies on physical activity produced using data from ELSA-Brasil participants...
July 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28758594/effects-of-resveratrol-and-ace-inhibitor-enalapril-on-glucose-and-lipid-profiles-in-mice
#10
Thaisa de Almeida Pinheiro, Thales de Almeida Pinheiro, Jonh David Feltenberger, João Marcus Oliveira Andrade, Emillio César Ferreira, Deborah De Farias Lelis, Andre Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Antônio Prates Caldeira, Sérgio Henrique Sousa Santos
Lipogenesis is a process that involves the synthesis of fatty acids. Resveratrol and enalapril are being studied for their beneficial physiological properties on the glucose and lipid metabolism. The aim of the present study was to evaluate the oral administration of resveratrol and enalapril on the glucose and lipid metabolism, evaluating the white pad lipogenesis genes expression in mice. Swiss male mice were divided into four groups and treated for eight weeks as follows: Standard diet ad libitum (G1); Standard diet + Resveratrol (G2); Standard diet + Enalapril (G3); Standard diet + Resveratrol + Enalapril (G4), where resveratrol was administered with the food and enalapril with the water...
July 28, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28752106/in-vivo-analysis-of-neutrophil-infiltration-during-lps-induced-peritonitis
#11
Lucia de Almeida, Andrea Dorfleutner, Christian Stehlik
Bacterial lipopolysaccharide (LPS) is present in the outer membrane of Gram-negative bacteria and functions as pathogen-associated molecular pattern (PAMP) (Whitfield and Trent, 2014). LPS therefore is a potent activator of inflammatory responses leading to cytokine release and neutrophils recruitment. The lipid A moiety of LPS activates the complex consisting of the LPS binding protein (LBP), CD14, MD-2 and Toll-like receptor 4 (TLR4) and the non-canonical inflammasome-linked caspases-4, 5 and 11, which in turn activate the canonical NLRP3 inflammasome (Shi et al...
October 5, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28738543/phenolic-compounds-of-triplaris-gardneriana-can-protect-cells-against-oxidative-stress-and-restore-oxidative-balance
#12
Thiago Silva de Almeida, José Joaquim Lopes Neto, Nathanna Mateus de Sousa, Igor Parra Pessoa, Leonardo Rogério Vieira, Jackeline Lima de Medeiros, Aline Augusti Boligon, Astrid R M Hamers, Davi Felipe Farias, Ad Peijnenburg, Ana Fontenele Urano Carvalho
This work aimed to add value to an underexploited plant species from Brazil, Triplaris gardneriana. To that, the phenolic compounds profile of its seed ethanolic extract and fractions was examined by HPLC and the antioxidant capacity assessed using chemical assays as well as in vitro cell imaging. Twelve compounds were quantified and classified as either phenolic acids or flavonoids. The fractionation process did not generate fractions with different compositions except for chloroformic fraction, which showed only 6 out of 12 standard compounds used...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28732311/solid-and-aqueous-magnetoliposomes-as-nanocarriers-for-a-new-potential-drug-active-against-breast-cancer
#13
Ana Rita O Rodrigues, Pedro M F Mendes, Pedro M L Silva, V A Machado, Bernardo G Almeida, J P Araújo, Maria-João R P Queiroz, Elisabete M S Castanheira, Paulo J G Coutinho
Iron oxide nanoparticles, with diameters around 12nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7Oe and a blocking temperature of 118K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28728958/effectiveness-of-resistance-exercise-compared-to-aerobic-exercise-without-insulin-therapy-in-patients-with-type-2-diabetes-mellitus-a-meta-analysis
#14
REVIEW
Cybelle Nery, Silvia Regina Arruda De Moraes, Karyne Albino Novaes, Márcio Almeida Bezerra, Patrícia Verçoza De Castro Silveira, Andrea Lemos
BACKGROUND: Physical exercise has been used to mitigate the metabolic effects of diabetes mellitus. OBJECTIVE: To evaluate the effect of resistance exercise when compared to aerobic exercise without insulin therapy on metabolic and clinical outcomes in patients with type 2 diabetes mellitus. METHODS: Papers were searched on the databases MEDLINE/PubMed, CINAHL, SPORTDiscus, LILACS, and SCIELO, without language or date of publication limits...
July 5, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28719874/combined-effects-of-temperature-and-clomazone-gamit-%C3%A2-on-oxidative-stress-responses-and-b-esterase-activity-of-physalaemus-nattereri-leiuperidae-and-rhinella-schneideri-bufonidae-tadpoles
#15
Juliane Silberschmidt Freitas, Andreia Arantes Felício, Fabrício Barreto Teresa, Eduardo Alves de Almeida
Temperature is an important factor influencing the toxicity of chemicals in aquatic environments. Neotropical tadpoles experience large temperature fluctuations in their habitats and many species are distributed in areas impacted by agriculture. This study evaluated the effects caused by the exposure to clomazone (Gamit(®)) at different temperatures (28, 32 and 36 °C) on biochemical stress responses and esterase activities in Physalaemus nattereri and Rhinella schneideri tadpoles. Results evidenced that temperature modulates the effects of clomazone on biochemical response of tadpoles...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28716627/membrane-proteins-structures-a-review-on-computational-modeling-tools
#16
REVIEW
Jose G Almeida, Antonio J Preto, Panagiotis I Koukos, Alexandre M J J Bonvin, Irina S Moreira
BACKGROUND: Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental methods and provide valuable insights...
July 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28690872/physiological-and-lipid-profile-response-to-acute-exercise-at-different-intensities-in-individuals-with-spinal-cord-injury
#17
Eduardo S Alves, Ronaldo Vt Santos, Francieli S Ruiz, Fabio S Lira, Alexandre A Almeida, Giscard Lima, Thatiana Cs Goni, Lila Oyama, Kate M Edwards, Sergio Tufik, Marco Túlio De Mello
STUDY DESIGN: Experimental and cross-sectional study. OBJECTIVE: To assess the immediate effect of exercise on heart rate (HR), oxygen uptake (VO2), pulmonary ventilation (PV), oxygen pulse (OP), glucose and lipids of wheelchair basketball players with spinal cord injury (SCI). SETTING: Center of Studies in Psychobiology and Exercise-São Paulo, Brazil. METHODS: In all, nine wheelchair basketball players with SCI and nine able-bodied controls (C) performed three exercise sessions at different intensities: ventilatory threshold 1 (VT1), 15% below VT1 and 15% above VT1 with a duration of ~24-34 min...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28663714/biodegradable-seeds-of-holmium-don-t-change-neurological-function-after-implant-in-brain-of-rats
#18
Mirla Fiuza Diniz, Diogo Milioli Ferreira, Wanderson Geraldo de Lima, Maria Lucia Pedrosa, Marcelo Eustáquio Silva, Stanley de Almeida Araujo, Kinulpe Honorato Sampaio, Tarcisio Passos Ribeiro de Campos, Savio Lana Siqueira
AIM: To evaluate the surgical procedure and parenchymal abnormalities related to implantation of ceramic seeds with holmium-165 in rats' brain. BACKGROUND: An effective method of cancer treatment is brachytherapy in which radioactive seeds are implanted in the tumor, generating a high local dose of ionizing radiation that can eliminate tumor cells while protecting the surrounding healthy tissue. Biodegradable Ho(166)-ceramic-seeds have been addressed recently. METHODS AND MATERIALS: The experiments in this study were approved by the Ethics Committee on Animal Use at the Federal University of Ouro Preto, protocol number 2012/034...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28659880/alkyl-protocatechuate-loaded-nanostructured-lipid-systems-as-a-treatment-strategy-for-paracoccidioides-brasiliensis-and-paracoccidioides-lutzii-in-vitro
#19
Kaila P Medina-Alarcón, Junya L Singulani, Aline R Voltan, Janaina C O Sardi, Maicon S Petrônio, Mariana B Santos, Carlos R Polaquini, Luis O Regasini, Vanderlan S Bolzani, Dulce H S da Silva, Marlus Chorilli, Maria J S Mendes-Giannini, Ana M Fusco-Almeida
Dodecyl protocatechuate (dodecyl) is a derivative of protocatechuic acid (3,4-dihydroxybenzoic acid) that possesses anti-oxidant and antifungal properties. Nanostructured lipid systems (NLS) can potentiate the action of many antifungal agents, reducing the required dose and side effects by improving their activity. This work aimed to evaluate dodecyl protocatechuate loaded into a NLS (NLS+dodecyl) as a strategy for the treatment of Paracoccidioides brasiliensis and P. lutzii in vitro. Antifungal activity against P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28659627/anti-parasite-therapy-drives-changes-in-human-visceral-leishmaniasis-associated-inflammatory-balance
#20
Théo Araújo-Santos, Bruno B Andrade, Leonardo Gil-Santana, Nívea F Luz, Priscila L Dos Santos, Fabrícia A de Oliveira, Meirielly Lima Almeida, Roseane Nunes de Santana Campos, Patrícia T Bozza, Roque P Almeida, Valeria M Borges
Visceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. VL patients displayed substantial increases in serum levels of Prostaglandin F2α (PGF2α), Leukotriene B4 (LTB4), Resolvin D1 (RvD1), IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α compared with uninfected endemic control group, while exhibiting decreased levels of TGF-β1...
June 28, 2017: Scientific Reports
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