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https://www.readbyqxmd.com/read/29337238/advantages-of-the-alpha-lipoic-acid-association-with-chlorpromazine-in-a-model-of-schizophrenia-induced-by-ketamine-in-rats-behavioral-and-oxidative-stress-evidences
#1
Luis Rafael Leite Sampaio, Francisco Maurício Sales Cysne Filho, Jamily Cunha de Almeida, Danilo Dos Santos Diniz, Cláudio Felipe Vasconcelos Patrocínio, Caren Nádia Soares de Sousa, Manoel Cláudio Azevedo Patrocínio, Danielle S Macêdo, Silvânia Maria Mendes Vasconcelos
Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population. Although its pathophysiological process is not completely elucidated, evidence showing the presence of an oxidative imbalance has been increasingly highlighted in the literature. Thus, the use of antioxidant substances may be of importance for schizophrenia treatment. The objective of this study was to evaluate the behavioral and oxidative alterations by the combination of chlorpromazine (CP) and alpha-lipoic acid (ALA), a potent antioxidant, in the ketamine (KET) model of schizophrenia in rats...
January 11, 2018: Neuroscience
https://www.readbyqxmd.com/read/29318970/physicochemical-characterization-and-skin-permeation-of-cationic-transfersomes-containing-the-synthetic-peptide-pnpp-19
#2
Flavia De Marco Almeida, Carolina Nunes Silva, Savia Caldeira de Araujo Lopes, Daniel Moreira Santos, Fernanda Silva Torres, Felipe Lima Cardoso, Patricia Massara Martinelli, Elizabeth Ribeiro da Silva, Maria Elena de Lima, Lucas Antonio Ferreira Miranda, Monica Cristina Oliveira
BACKGROUND: PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE: The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded transfersomes. METHOD: Three different liposomal preparation methods were evaluated. Cationic transfersomes contained egg phosphatidyl choline: stearylamine (9:1 w/w) and Tween 20 (84...
January 8, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29316941/homocysteine-folate-hs-c-reactive-protein-tumor-necrosis-factor-alpha-and-inflammatory-proteins-are-these-biomarkers-related-to-nutritional-status-and-cardiovascular-risk-in-childhood-onset-systemic-lupus-erythematosus
#3
Roberta Garcia Salomão, Luciana Martins de Carvalho, Clarice Izumi, Érika Silva Czernisz, José César Rosa, Sonir Roberto Rauber Antonini, Ana Carolina Bueno, Maria Olímpia Ribeiro do Vale Almada, Carolina de Almeida Coelho-Landell, Alceu Afonso Jordão, Virgínia Paes Leme Ferriani, Jacqueline Pontes Monteiro
BACKGROUND: Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein. METHODS: We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers...
January 9, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29300367/rational-design-of-a-new-class-of-toll-like-receptor-4-tlr4-tryptamine-related-agonists-by-means-of-the-structure-and-ligand-based-virtual-screening-for-vaccine-adjuvant-discovery
#4
Jan Honegr, Rafael Dolezal, David Malinak, Marketa Benkova, Ondrej Soukup, Joyce S F D de Almeida, Tanos C C Franca, Kamil Kuca, Roman Prymula
In order to identify novel lead structures for human toll-like receptor 4 (hTLR4) modulation virtual high throughput screening by a peta-flops-scale supercomputer has been performed. Based on the in silico studies, a series of 12 compounds related to tryptamine was rationally designed to retain suitable molecular geometry for interaction with the hTLR4 binding site as well as to satisfy general principles of drug-likeness. The proposed compounds were synthesized, and tested by in vitro and ex vivo experiments, which revealed that several of them are capable to stimulate hTLR4 in vitro up to 25% activity of Monophosphoryl lipid A...
January 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29288627/characterization-of-the-first-planctomycetal-outer-membrane-protein-identifies-a-channel-in-the-outer-membrane-of-the-anammox-bacterium-kuenenia-stuttgartiensis
#5
Muriel C F van Teeseling, Roland Benz, Naomi M de Almeida, Mike S M Jetten, Rob J Mesman, Laura van Niftrik
Planctomycetes are a bacterial phylum known for their complex intracellular compartmentalization. While most Planctomycetes have two compartments, the anaerobic ammonium oxidizing (anammox) bacteria contain three membrane-enclosed compartments. In contrast to a long-standing consensus, recent insights suggested the outermost Planctomycete membrane to be similar to a Gram-negative outer membrane (OM). One characteristic component that differentiates OMs from cytoplasmic membranes (CMs) is the presence of outer membrane proteins (OMPs) featuring a ß-barrel structure that facilitates passage of molecules through the OM...
December 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29248837/isolated-and-mixed-effects-of-diuron-and-its-metabolites-on-biotransformation-enzymes-and-oxidative-stress-response-of-nile-tilapia-oreochromis-niloticus
#6
Andréia Arantes Felício, Juliane Silberschmidt Freitas, Jéssica Bolpeti Scarin, Luciana de Souza Ondei, Fabrício Barreto Teresa, Daniel Schlenk, Eduardo Alves de Almeida
Diuron is one of the most used herbicide in the world, and its field application has been particularly increased in Brazil due to the expansion of sugarcane crops. Diuron has often been detected in freshwater ecosystems and it can be biodegraded into three main metabolites in the environment, the 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU). Negative effects under aquatic biota are still not well established for diuron, especially when considering its presence in mixture with its different metabolites...
December 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29237373/editorial-applications-of-solid-lipid-nanoparticles-sln-and-nanostructured-lipid-carriers-nlc-state-of-the-art
#7
EDITORIAL
Ana Catarina Silva, Maria Helena Amaral, Jose Manuel Sousa Lobo, Hugo Almeida
No abstract text is available yet for this article.
December 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29221989/differential-targeting-of-membrane-lipid-domains-by-caffeic-acid-and-its-ester-derivatives
#8
Hugo A L Filipe, Carla Sousa, Joaquim T Marquês, Diogo Vila-Viçosa, António de Granada Flor, Ana S Viana, M Soledade C S Santos, Miguel Machuqueiro, Rodrigo F M de Almeida
Phenolic acids have been associated to a wide range of important health benefits underlain by a common molecular mechanism of action. Considering that significant membrane permeation is prevented by their hydrophilic character, we hypothesize that their main effects result from the interplay with cell membrane surface. This hypothesis was tested using the paradigmatic caffeic acid (CA) and two of its ester derivatives, rosmarinic (RA) and chlorogenic (CGA) acids, for which we predict, based on molecular dynamics simulations, a shallow location in phospholipid bilayers dependent on the protonation-state...
December 5, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29198636/prolonged-diuretic-and-saluretic-effect-of-nothofagin-isolated-from-leandra-dasytricha-a-gray-cogn-leaves-in-normotensive-and-hypertensive-rats-role-of-antioxidant-system-and-renal-protection
#9
Camila Leandra Bueno de Almeida, Valdir Cechinel-Filho, Thaise Boeing, Luísa Nathália Bolda Mariano, Luísa Mota da Silva, Sérgio Faloni de Andrade, Priscila de Souza
Although the acute diuretic effect of nothofagin has been recently demonstrated, its effects after dose-repeated treatment have not yet been explored. For that, male Wistar normotensive (NTR) and spontaneously hypertensive rats (SHR) were orally treated, once a day, with vehicle (VEH: distilled water; 1 ml/kg), hydrochlorothiazide (HCTZ; 10 mg/kg) or nothofagin (NOT; 1 mg/kg). The cumulative diuretic index and urinary electrolytes excretion were measured each 24 h. On the last day of the experiment (7th day), urine, blood and kidney samples were collected for biochemical and molecular analyzes...
November 30, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29189138/intranasal-lipid-nanoparticles-for-the-treatment-of-neurodegenerative-diseases
#10
S Cunha, H Almeida, M H Amaral, J M Sousa Lobo, A C Silva
BACKGROUND: Current treatments for neurodegenerative diseases are challenging, due to the absence of full effective medicines. One of the major problems associated to these is the occurrence of non-targeting events, which leads to adverse effects and requires frequent dose administration. METHODS: Researches have been performed to develop new drug delivery systems administrated by alternative routes. For example, the direct nose-to-brain delivery of drugs by means of lipid nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), have been showing promising results...
November 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29186558/essential-role-for-phytol-kinase-and-tocopherol-in-tolerance-to-combined-light-and-temperature-stress-in-tomato
#11
Livia Spicher, Juliana Almeida, Katharina Gutbrod, Rosa Pipitone, Peter Dörmann, Gaétan Glauser, Magdalena Rossi, Felix Kessler
In a changing environment, plants need to cope with the impact of rising temperatures together with high light intensity. Here, we used lipidomics in the tomato model system to identify lipophilic molecules that enhance tolerance to combined high-temperature and high-light stress. Among several hundred metabolites, the two most strongly up-regulated compounds were α-tocopherol and plastoquinone/plastoquinol. Both are well-known lipid antioxidants and contribute to the protection of photosystem II (PSII) against photodamage under environmental stress...
November 24, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29172149/exposure-to-deltamethrin-induces-oxidative-stress-and-decreases-of-energy-reserve-in-tissues-of-the-neotropical-fruit-eating-bat-artibeus-lituratus
#12
Jerusa Maria Oliveira, Nicole Fontes Losano, Suellen Silva Condessa, Renata Maria Pereira de Freitas, Silvia Almeida Cardoso, Mariella Bontempo Freitas, Leandro Licursi de Oliveira
Deltamethrin (DTM) is a synthetic pyrethroid insecticide highly used by farmers and home users. This pesticide has lipophilic properties that facilitate a high absorption and can cause toxicity in non-target organisms. During foraging, the fruit-eating bats Artibeus lituratus are exposed to pesticides. However, the knowledge of the toxicity of pesticides on the physiology of bats is relatively scarce. This study aimed to check the toxicity of short-term exposure to low concentration of DTM on fruit-eating bat A...
November 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29158138/different-ecophysiological-responses-of-freshwater-fish-to-warming-and-acidification
#13
Tiago F Jesus, Inês C Rosa, Tiago Repolho, Ana R Lopes, Marta S Pimentel, Vera M F Almeida-Val, Maria M Coelho, Rui Rosa
Future climate change scenarios predict threatening outcomes to biodiversity. Available empirical data concerning biological response of freshwater fish to climate change remains scarce. In this study, we investigated the physiological and biochemical responses of two Iberian freshwater fish species (Squalius carolitertii and the endangered S. torgalensis), inhabiting different climatic conditions, to projected future scenarios of warming (+3°C) and acidification (ΔpH=-0.4). Herein, metabolic enzyme activities of glycolytic (citrate synthase - CS, lactate dehydrogenase - LDH) and antioxidant (glutathione S-transferase, catalase and superoxide dismutase) pathways, as well as the heat shock response (HSR) and lipid peroxidation were determined...
November 17, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29148894/metabolic-profile-in-patients-with-mild-obstructive-sleep-apnea
#14
Luciana Oliveira E Silva, Thais M Guimarães, Gabriela P Luz, Glaury Coelho, Luciana Badke, Ildonete R Almeida, Aline Millani-Carneiro, Sergio Tufik, Lia Bittencourt, Sonia M Togeiro
BACKGROUND: Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults. However, it is not clear whether mild OSA has significant metabolic complications. This study examined the prevalence of metabolic syndrome (MS) in patients with mild OSA compared to control group. METHODS: Adults (18-65 years of age) of both genders with a body mass index (BMI) ≤35 kg/m2 were included. The mild OSA group comprised of patients with an apnea-hypopnea index (AHI) score of ≥5 but ≤15 events/hr of sleep, independent of other symptoms...
November 17, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29130685/daptomycin-phosphatidylglycerol-domains-in-lipid-membranes
#15
Mark A Kreutzberger, Antje Pokorny, Paulo F Almeida
Daptomycin is an acidic, 13-amino acid, cyclic polypeptide that contains a number of nonproteinogenic residues and is modified at its N-terminus with a decanoyl chain. It has been in clinical use since 2003 against selected drug-resistant Staphylococcus aureus and Enterococcus spp infections. In vitro, daptomycin is active against Gram-positive pathogens at low concentrations but its antibiotic activity depends critically on the presence of calcium ions. This dependence has been thought to arise from binding of one or two Ca(2+) ions to daptomycin as a required step in its interaction with the bacterial membrane...
November 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29126754/effect-of-pulsed-therapeutic-ultrasound-and-diosmin-on-skeletal-muscle-oxidative-parameters
#16
Luis Fernando Sousa Filho, Paula P Menezes, Dayanne Valéria Soares Santana, Bruno S Lima, Shanmugan Saravanan, Grace Kelly M Almeida, José Evaldo R Menezes Filho, Marta M B Santos, Adriano Antunes A S Araújo, Evaleide Diniz de Oliveira
Cyclodextrins (CDs) have been widely used as a promising alternative in the formation of inclusion complexes with poorly soluble molecules. From this perspective, the present study aimed to study the inclusion complexes of diosmin in β-cyclodextrin, chemically quantify the diosmin-in-gel preparation and analyze the stability of the gels. Furthermore, we evaluated the effect of therapeutic pulsed ultrasound (TPU) in association with the gel-diosmin complex on the parameters of muscle damage and oxidative stress in rats...
November 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29110748/perinatal-maternal-high-fat-diet-induces-early-obesity-and-sex-specific-alterations-of-the-endocannabinoid-system-in-white-and-brown-adipose-tissue-of-weanling-rat-offspring
#17
Mariana M Almeida, Camilla P Dias-Rocha, André S Souza, Mariana F Muros, Leonardo S Mendonca, Carmen C Pazos-Moura, Isis H Trevenzoli
Perinatal maternal high-fat (HF) diet programmes offspring obesity. Obesity is associated with overactivation of the endocannabinoid system (ECS) in adult subjects, but the role of the ECS in the developmental origins of obesity is mostly unknown. The ECS consists of endocannabinoids, cannabinoid receptors (cannabinoid type-1 receptor (CB1) and cannabinoid type-2 receptor (CB2)) and metabolising enzymes. We hypothesised that perinatal maternal HF diet would alter the ECS in a sex-dependent manner in white and brown adipose tissue of rat offspring at weaning in parallel to obesity development...
November 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29098221/the-molecular-mechanism-of-nystatin-action-is-dependent-on-the-membrane-biophysical-properties-and-lipid-composition
#18
A G Dos Santos, J T Marquês, A C Carreira, I R Castro, A S Viana, M-P Mingeot-Leclercq, R F M de Almeida, L C Silva
Nystatin (Nys) is a pore forming broad-spectrum and efficient antifungal drug with significant toxicity in mammalian organisms. In order to develop a non-toxic and more effective Nys formulation, its molecular mechanism of action at the cell membrane needs to be better understood. It is widely accepted that Nys activity and toxicity depend on the presence and type of membrane sterols. Taking advantage of multiple biophysical methodologies, we now show that the formation and stabilization of Nys aqueous pores, which are associated with Nys cytotoxicity, occur in the absence of membrane sterols...
November 3, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29063477/easy-fast-and-reproducible-quantification-of-cholesterol-and-other-lipids-in-human-plasma-by-combined-high-resolution-msx-and-ftms-analysis
#19
Sandra F Gallego, Kurt Højlund, Christer S Ejsing
Reliable, cost-effective, and gold-standard absolute quantification of non-esterified cholesterol in human plasma is of paramount importance in clinical lipidomics and for the monitoring of metabolic health. Here, we compared the performance of three mass spectrometric approaches available for direct detection and quantification of cholesterol in extracts of human plasma. These approaches are high resolution full scan Fourier transform mass spectrometry (FTMS) analysis, parallel reaction monitoring (PRM), and novel multiplexed MS/MS (MSX) technology, where fragments from selected precursor ions are detected simultaneously...
October 23, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29053478/%C3%AE-lipoic-acid-as-adjunctive-treatment-for-schizophrenia-an-open-label-trial
#20
Lia Lira Olivier Sanders, Carlos Eduardo de Souza Menezes, Adriano José Maia Chaves Filho, Glautemberg de Almeida Viana, Francisco Vagnaldo Fechine, Maria Goretti Rodrigues de Queiroz, Said Gonçalvez da Cruz Fonseca, Silvânia Maria Mendes Vasconcelos, Maria Elisabete Amaral de Moraes, Clarissa S Gama, Sheila Seybolt, Eugênio de Moura Campos, Danielle Macêdo, David Freitas de Lucena
PURPOSE/BACKGROUND: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae. α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy. METHODS/PROCEDURES: In this pilot investigation, we administered ALA (100 mg/d) for 4 months, as an adjunct to antipsychotic medication, to 10 patients with schizophrenia...
December 2017: Journal of Clinical Psychopharmacology
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