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https://www.readbyqxmd.com/read/27880808/natural-schistosoma-mansoni-infection-in-the-wild-reservoir-nectomys-squamipes-leads-to-excessive-lipid-droplet-accumulation-in-hepatocytes-in-the-absence-of-liver-functional-impairment
#1
Kátia B Amaral, Thiago P Silva, Kássia K Malta, Lívia A S Carmo, Felipe F Dias, Mariana R Almeida, Gustavo F S Andrade, Jefferson S Martins, Roberto R Pinho, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
Schistosomiasis is a neglected tropical disease of a significant public health impact. The water rat Nectomys squamipes is one of the most important non-human hosts in the schistosomiasis mansoni transmission in Brazil, being considered a wild reservoir. Cellular mechanisms that contribute to the physiological adaptation of this rodent to the Schistosoma mansoni parasite are poorly understood. Here we identified, for the first time, that a hepatic steatosis, a condition characterized by excessive lipid accumulation with formation of lipid droplets (LDs) within hepatocytes, occurs in response to the natural S...
2016: PloS One
https://www.readbyqxmd.com/read/27871882/schistosomal-derived-lysophosphatidylcholine-triggers-m2-polarization-of-macrophages-through-ppar%C3%AE-dependent-mechanisms
#2
Leonardo Santos Assunção, Kelly G Magalhães, Alan Brito Carneiro, Raphael Molinaro, Patrícia E Almeida, Georgia C Atella, Hugo C Castro-Faria-Neto, Patrícia T Bozza
Mansonic schistosomiasis is a disease caused by the trematode Schistosoma mansoni, endemic to tropical countries. S. mansoni infection induces the formation of granulomas and potent polarization of Th2-type immune response. There is great interest in understanding the mechanisms used by this parasite that causes a modulation of the immune system. Recent studies from our group demonstrated that lipids of S. mansoni, including lysophosphatidylcholine (LPC) have immunomodulatory activity. In the present study, our aim was to investigate the role of lipids derived from S...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27871310/transcriptome-analysis-reveals-manifold-mechanisms-of-cyst-development-in-adpkd
#3
Rita M C de Almeida, Sherry G Clendenon, William G Richards, Michael Boedigheimer, Michael Damore, Sandro Rossetti, Peter C Harris, Britney-Shea Herbert, Wei Min Xu, Angela Wandinger-Ness, Heather H Ward, James A Glazier, Robert L Bacallao
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) causes progressive loss of renal function in adults as a consequence of the accumulation of cysts. ADPKD is the most common genetic cause of end-stage renal disease. Mutations in polycystin-1 occur in 87% of cases of ADPKD and mutations in polycystin-2 are found in 12% of ADPKD patients. The complexity of ADPKD has hampered efforts to identify the mechanisms underlying its pathogenesis. No current FDA (Federal Drug Administration)-approved therapies ameliorate ADPKD progression...
November 21, 2016: Human Genomics
https://www.readbyqxmd.com/read/27870966/biochemical-effects-of-fipronil-and-its-metabolites-on-lipid-peroxidation-and-enzymatic-antioxidant-defense-in-tadpoles-eupemphix-nattereri-leiuperidae
#4
Hortênsia S Gripp, Juliane S Freitas, Eduardo A Almeida, Márcia C Bisinoti, Altair B Moreira
Amphibians are very sensitive to environmental change and pollution because they have both aquatic and terrestrial life cycle stages and high skin permeability. Particularly during the larval stages, when these animals are restricted to small, transient ponds, exposure to high concentrations of pesticides is inevitable in agricultural areas. Given that pesticide application increases during the summer, which coincides with the reproductive season and the occurrence of most neotropical tadpoles in their natural environment, strong indications exist that tadpoles are developing in contaminated ponds...
November 18, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27864069/microencapsulated-sln-an-innovative-strategy-for-pulmonary-protein-delivery
#5
Diana P Gaspar, Carmen Serra, Paulo R Lino, Lídia Gonçalves, Pablo Taboada, Carmen Remuñán-López, António J Almeida
Associating protein with nanoparticles is an interesting strategy to improve their bioavailability and biological activity. Solid lipid nanoparticles (SLN) have been sought as carriers for therapeutic proteins transport to the lung epithelium. Nevertheless, because of their low inertia, nanoparticles intended for pulmonary application usually escape from lung deposition. To overcome this problem, the production of spray-dried powders containing nanoparticles has been recently reported. Herein we developed new hybrid microencapsulated SLN for pulmonary administration, containing a model protein (papain, PAP)...
November 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27815222/reorganization-of-plasma-membrane-lipid-domains-during-conidial-germination
#6
Filipa C Santos, Andreia S Fernandes, Catarina A C Antunes, Filipe P Moreira, Arnaldo Videira, H Susana Marinho, Rodrigo F M de Almeida
Neurospora crassa, a filamentous fungus, in the unicellular conidial stage has ideal features to study sphingolipid (SL)-enriched domains, which are implicated in fundamental cellular processes ranging from antifungal resistance to apoptosis. Several changes in lipid metabolism and in the membrane composition of N. crassa occur during spore germination. However, the biophysical impact of those changes is unknown. Thus, a biophysical study of N. crassa plasma membrane, particularly SL-enriched domains, and their dynamics along conidial germination is prompted...
November 1, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27775058/extracellular-vesicles-from-paracoccidioides-brasiliensis-induced-m1-polarization-in-vitro
#7
Thiago Aparecido da Silva, Maria Cristina Roque-Barreira, Arturo Casadevall, Fausto Almeida
Extracellular vesicles (EVs) released by eukaryotes, archaea, and bacteria contain proteins, lipids, polysaccharides, and other molecules. The cargo analysis of EVs shows that they contain virulence factors suggesting a role in the pathogenesis of infection. The proteome, lipidome, RNA content, and carbohydrate composition of EVs from Paracoccidioides brasiliensis and Paracoccidioides lutzii were characterized. However, the effects of P. brasiliensis EVs on the host immune system have not yet been investigated...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27760360/charge-distribution-fine-tunes-the-translocation-of-%C3%AE-helical-amphipathic-peptides-across-membranes
#8
Francis D O Ablan, B Logan Spaller, Kaitlyn I Abdo, Paulo F Almeida
Hundreds of cationic antimicrobial and cell-penetrating peptides (CPPs) form amphipathic α-helices when bound to lipid membranes. Here, we test two hypotheses for the differences in the ability of these peptides to translocate across membranes. The first, which we now call the hydrophobicity hypothesis, is that peptide translocation is determined by the Gibbs energy of insertion into the bilayer from the membrane interface. The second, which we call the charge-distribution hypothesis, is that translocation is determined by whether the distribution of cationic residues in the peptide can transiently stabilize a high-energy inserted intermediate by forming salt bridges to the phosphates of lipid headgroups...
October 18, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27760188/genotyping-and-descriptive-proteomics-of-a-potential-zoonotic-canine-strain-of-giardia-duodenalis-infective-to-mice
#9
Camila Henriques Coelho, Adriana Oliveira Costa, Ana Carolina Carvalho Silva, Maíra Mazzoni Pucci, Angela Vieira Serufo, Haendel Goncalves Nogueira Oliveira Busatti, Maurício Durigan, Jonas Perales, Alex Chapeaurouge, Daniel Almeida da Silva E Silva, Maria Aparecida Gomes, Juliano Simões Toledo, Steven M Singer, Rosiane A Silva-Pereira, Ana Paula Fernandes
The zoonotic potential of giardiasis, as proposed by WHO since the late 70's, has been largely confirmed in this century. The genetic assemblages A and B of Giardia duodenalis are frequently isolated from human and canine hosts. Most of the assemblage A strains are not infective to adult mice, which can limit the range of studies regarding to biology of G. duodenalis, including virulence factors and the interaction with host immune system. This study aimed to determine the infectivity in mice of an assemblage A Giardia duodenalis strain (BHFC1) isolated from a dog and to classify the strain in sub-assemblages (AI, AII, AIII) through the phylogenetic analysis of beta-giardin (bg), triose phosphate isomerase (tpi) and glutamate dehydrogenase (gdh) genes...
2016: PloS One
https://www.readbyqxmd.com/read/27720634/coarse-grained-simulations-of-hemolytic-peptide-%C3%AE-lysin-interacting-with-a-popc-bilayer
#10
Mariah J King, Ashley L Bennett, Paulo F Almeida, Hee-Seung Lee
δ-lysin, secreted by a Gram-positive bacterium Staphylococcus aureus, is a 26-residue membrane active peptide that shares many common features with antimicrobial peptides (AMPs). However, it possesses a few unique features that differentiate itself from typical AMPs. In particular, δ-lysin has zero net charge, even though it has many charged residues, and it preferentially lyses eukaryotic cells over bacterial cells. Here, we present the results of coarse-grained molecular dynamics simulations of δ-lysin interacting with a zwitterionic membrane over a wide range of peptide concentrations...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27695439/encapsulation-into-stealth-liposomes-enhances-the-antitumor-action-of-recombinant-cratylia-mollis-lectin-expressed-in-escherichia-coli
#11
Cássia R A da Cunha, Luís C N da Silva, Fábio J F Almeida, Milena S Ferraz, Nathalia Varejão, Marina F de Souza Cartaxo, Rita de Cássia M de Miranda, Francisco C A de Aguiar, Noemia P da Silva Santos, Luana C B B Coelho, Nereide S Santos-Magalhães, Maria T Dos Santos Correia
This study evaluated the in vivo antitumor potential of the recombinant lectin from seeds of Cratylia mollis (rCramoll) expressed in Escherichia coli, free or encapsulated in stealth liposomes, using mice transplanted with sarcoma 180. rCramoll-loaded stealth liposomes (rCramoll-lipo) were formulated by hydration of the lipid film followed by cycles of freezing and thawing, and about 60% of rCramoll was encapsulated. This novel preparation showed particle size, polydispersity index, and pH suitable for the evaluation of antitumor activity in vivo...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27688827/antioxidant-and-vasodilator-activity-of-ugni-molinae-turcz-murtilla-and-its-modulatory-mechanism-in-hypotensive-response
#12
Ignacio Jofré, Cesar Pezoa, Magdalena Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27622676/chronic-stress-is-associated-with-reduced-circulating-hematopoietic-progenitor-cell-number-a-maternal-caregiving-model
#13
Kirstin Aschbacher, Jeffrey M Milush, Amanda Gilbert, Carlos Almeida, Elizabeth Sinclair, Lorrie Epling, S Marlene Grenon, Elysa J Marco, Eli Puterman, Elissa Epel
BACKGROUND: Chronic psychological stress is a risk factor for cardiovascular disease and mortality. Circulating hematopoietic progenitor cells (CPCs) maintain vascular homeostasis, correlate with preclinical atherosclerosis, and prospectively predict cardiovascular events. We hypothesize that 1) chronic caregiving stress is related to reduced CPC number, and 2) this may be explained in part by negative interactions within the family. METHODS: We investigated levels of stress and CPCs in 68 healthy mothers - 31 of these had children with an autism spectrum disorder (M-ASD) and 37 had neurotypical children (M-NT)...
September 10, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27604268/enhancing-glycan-isomer-separations-with-metal-ions-and-positive-and-negative-polarity-ion-mobility-spectrometry-mass-spectrometry-analyses
#14
Xueyun Zheng, Xing Zhang, Nathaniel S Schocker, Ryan S Renslow, Daniel J Orton, Jamal Khamsi, Roger A Ashmus, Igor C Almeida, Keqi Tang, Catherine E Costello, Richard D Smith, Katja Michael, Erin S Baker
Glycomics has become an increasingly important field of research since glycans play critical roles in biology processes ranging from molecular recognition and signaling to cellular communication. Glycans often conjugate with other biomolecules, such as proteins and lipids, and alter their properties and functions, so glycan characterization is essential for understanding the effects they have on cellular systems. However, the analysis of glycans is extremely difficult due to their complexity and structural diversity (i...
September 7, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27598982/circulating-early-biomarkers-of-atherogenesis-in-participants-of-the-longitudinal-study-of-adult-health-elsa-brasil-without-diabetes-or-cardiovascular-disease
#15
Bianca de Almeida-Pititto, Fernando Flexa Ribeiro-Filho, Sandhi Barreto, Bruce B Duncan, Maria Inês Schmidt, Paulo A Lotufo, Isabela M Bensenor, Sandra R G Ferreira
Objective: Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods: This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles...
September 5, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27580834/nutritionists-health-study-cohort-a-web-based-approach-of-life-events-habits-and-health-outcomes
#16
Luciana Gavilan Dias Folchetti, Isis Tande da Silva, Bianca de Almeida-Pititto, Sandra Roberta G Ferreira
INTRODUCTION: Non-communicable chronic diseases (NCCDs) represent a burden for public health. Alongside the established cardiometabolic risk factors such as high blood pressure and disorders of glucose and lipid metabolism, living habits and nutritional status at different stages of life are seen as contributors to this scenario. Gut microbiota composition and subclinical inflammation have been pointed out as underlying mechanisms of NCCDs. Studies involving health professionals have brought relevant contributions to the knowledge about risk factors...
2016: BMJ Open
https://www.readbyqxmd.com/read/27550907/association-between-carotid-intima-media-thickness-and-adiponectin-in-participants-without-diabetes-or-cardiovascular-disease-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#17
Bianca de Almeida-Pititto, Fernando Flexa Ribeiro-Filho, Itamar S Santos, Paulo A Lotufo, Isabela M Bensenor, Sandra Rg Ferreira
OBJECTIVE: The study assessed the association of adiponectin concentration with carotid intima-media thickness (CIMT) in middle-aged participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease. DESIGN: Cross-sectional analyses. METHODS: A sample of 687 individuals (35-54 years old) without diabetes or cardiovascular disease was stratified into two categories according to CIMT (< or ≥ 75th percentile)...
August 22, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27548151/dextran-influence-of-molecular-weight-in-antioxidant-properties-and-immunomodulatory-potential
#18
Vinicius C Soeiro, Karoline R T Melo, Monique G C F Alves, Mayara J C Medeiros, Maria L P M Grilo, Jailma Almeida-Lima, Daniel L Pontes, Leandro S Costa, Hugo A O Rocha
Dextrans (α-d-glucans) extracted from Leuconostoc mesenteroides, with molecular weights (MW) of 10 (D10), 40 (D40) and 147 (D147) kDa, were evaluated as antioxidant, anticoagulant and immunomodulatory drugs for the first time. None presented anticoagulant activity. As for the antioxidant and immunomodulatory tests, a specific test showed an increase in the dextran activity that was proportional to the increase in molecular weight. In a different assay, however, activity decreased or showed no correlation to the MW...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27540288/fungal-diseases-could-nanostructured-drug-delivery-systems-be-a-novel-paradigm-for-therapy
#19
REVIEW
Aline Raquel Voltan, Guillermo Quindós, Kaila P Medina Alarcón, Ana Marisa Fusco-Almeida, Maria José Soares Mendes-Giannini, Marlus Chorilli
Invasive mycoses are a major problem for immunocompromised individuals and patients in intensive care units. Morbidity and mortality rates of these infections are high because of late diagnosis and delayed treatment. Moreover, the number of available antifungal agents is low, and there are problems with toxicity and resistance. Alternatives for treating invasive fungal infections are necessary. Nanostructured systems could be excellent carriers for antifungal drugs, reducing toxicity and targeting their action...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27532424/iron-content-affects-lipogenic-gene-expression-in-the-muscle-of-nelore-beef-cattle
#20
Wellison Jarles da Silva Diniz, Luiz Lehmann Coutinho, Polyana Cristine Tizioto, Aline Silva Mello Cesar, Caio Fernando Gromboni, Ana Rita Araújo Nogueira, Priscila Silva Neubern de Oliveira, Marcela Maria de Souza, Luciana Correia de Almeida Regitano
Iron (Fe) is an essential mineral for metabolism and plays a central role in a range of biochemical processes. Therefore, this study aimed to identify differentially expressed (DE) genes and metabolic pathways in Longissimus dorsi (LD) muscle from cattle with divergent iron content, as well as to investigate the likely role of these DE genes in biological processes underlying beef quality parameters. Samples for RNA extraction for sequencing and iron, copper, manganese, and zinc determination were collected from LD muscles at slaughter...
2016: PloS One
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