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https://www.readbyqxmd.com/read/28346808/patient-reported-outcomes-1-year-after-immediate-breast-reconstruction-results-of-the-mastectomy-reconstruction-outcomes-consortium-study
#1
Andrea L Pusic, Evan Matros, Neil Fine, Edward Buchel, Gayle M Gordillo, Jennifer B Hamill, Hyungjin M Kim, Ji Qi, Claudia Albornoz, Anne F Klassen, Edwin G Wilkins
Purpose The goals of immediate postmastectomy breast reconstruction are to minimize deformity and optimize quality of life as perceived by patients. We prospectively evaluated patient-reported outcomes (PROs) in women undergoing immediate implant-based or autologous reconstruction. Methods Women undergoing immediate postmastectomy reconstruction for invasive cancer and/or carcinoma in situ were enrolled at 11 sites. Women underwent implant-based or autologous tissue reconstruction. Patients completed the BREAST-Q, a condition-specific PRO measure for breast surgery patients, and Patient-Reported Outcomes Measurement Information System-29, a generic PRO measure, before and 1 year after surgery...
March 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28344979/psychological-profile-of-individuals-presenting-with-chronic-cough
#2
Katrin Hulme, Vincent Deary, Sian Dogan, Sean M Parker
Chronic refractory cough (CRC) is a common problem in respiratory clinics. Adverse effects on quality of life are documented in the literature, but relatively little is known about the underlying psychological factors in this patient population. We aimed to investigate the association of psychological factors with chronic cough, comparing CRC to explained cough and non-cough groups. 67 patients attending a specialist cough clinic (CRC, n=25; explained cough, n=42) and 22 non-cough individuals participated. All participants completed the Hospital Anxiety & Depression Scale, Big Five Inventory (Personality), Chalder Fatigue Scale and Patient Health Questionnaire-15...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28342990/telephone-adapted-mindfulness-based-stress-reduction-tmbsr-for-patients-awaiting-kidney-transplantation
#3
Cynthia R Gross, Maryanne Reilly-Spong, Taehwan Park, Ruizhi Zhao, Olga V Gurvich, Hassan N Ibrahim
BACKGROUND: Patients with progressive kidney disease experience increasing physiologic and psychosocial stressors and declining health-related quality of life (HRQOL). METHODS: We conducted a randomized, active-controlled, open-label trial to test whether a Mindfulness-based Stress Reduction (MBSR) program delivered in a novel workshop-teleconference format would reduce symptoms and improve HRQOL in patients awaiting kidney transplantation. Sixty-three transplant candidates were randomized to one of two arms: i) telephone-adapted MBSR (tMBSR, an 8-week program of meditation and yoga); or ii) a telephone-based support group (tSupport)...
March 22, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28339702/subclinical-chronic-left-ventricular-systolic-dysfunction-resulting-from-phosphine-poisoning
#4
E Szymczyk, M Wiszniewska, J Walusiak-Skorupa, J D Kasprzak, P Lipiec
We present a case of a 32-year-old male crew member of a cargo ship, accidentally exposed to phosphine, a fumigating substance. He and other crew members developed increasing fatigue and digestive disorders 24 h later; two died from acute pulmonary oedema. The patient was admitted to hospital, where bilateral pneumonia, acute nephritis, hepatopathy, electrolyte imbalance and leucopenia were diagnosed. He was discharged from hospital 3 weeks later. He was examined 4 months later for possible chronic consequences of acute phosphine poisoning, which included echocardiography showing normal heart size and cardiac function...
February 21, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28338413/human-tissue-engineered-skeletal-muscle-myobundles-to-measure-oxygen-uptake-and-assess-mitochondrial-toxicity
#5
Brittany N J Davis, Jeffrey W Santoso, Michaela J Walker, Cindy S Cheng, Timothy R Koves, William E Kraus, George A Truskey
Mitochondrial dysfunction is responsible for the toxicity of a number of drugs. Current isolated mitochondria or cellular monoculture mitochondrial respiration measurement systems lack physiological relevance. Using a tissue engineering rather than cell- or mitochondria-based approach enables a more physiologically relevant detection of drug-induced mitochondrial impairment. To probe oxygen consumption and mitochondrial health, we assayed the bioenergetic profile of engineered three-dimensional human skeletal muscle myobundles derived from primary myoblasts...
March 24, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28337866/fibromyalgia-and-bipolar-disorder-extent-of-comorbidity-and-therapeutic-implications
#6
M C Di Tommaso Morrison, F Carinci, G Lessiani, E Spinas, S K Kritas, G Ronconi, Al Caraffa, P Conti
Fibromyalgia (FM) is a syndrome that affects muscles and soft tissues. Presenting symptoms include chronic muscle pain, fatigue, sleep problems and psychological symptoms, including depression and anxiety. There exists strong evidence of a comorbidity between FM and Bipolar Disorder (BD). In this study, papers from 2006 to February 2016 that examined the comorbidity and etiological similarities of FM and BD were reviewed, as well as the therapeutic implications of these findings. The reviewed articles showed that an adequate psychiatric screening for BD is recommended in FM patients with depressive symptoms, in order to decrease administration of antidepressants for BD, due to the lack of proven efficacy, and to limit antidepressant-induced mania...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28336581/differential-impact-of-symptom-prevalence-and-chronic-conditions-on-quality-of-life-in-cancer-survivors-and-non-cancer-individuals-a-population-study
#7
I-Chan Huang, Melissa M Hudson, Leslie L Robison, Kevin R Krull
BACKGROUND: To compare associations of symptom prevalence, chronic conditions, and health-related quality of life (HRQOL) between cancer survivors and non-cancer individuals using the U.S. National Health Interview Survey. METHODS: Study samples comprised 604 survivors and 6,166 non-cancer individuals. Symptoms included sensation abnormality, pain, fatigue, cognitive disturbance, depression, and anxiety. Physical and mental HRQOL was measured by the Patient-Reported Outcomes Measurement Information System...
March 23, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28336154/socioeconomic-and-therapy-factor-influence-on-self-reported-fatigue-anxiety-and-depression-in-rheumatoid-arthritis-patients
#8
Mirjana Lapčević, Mira Vuković, Branislav S Gvozdenović, Vesna Mioljević, Snežana Marjanović
INTRODUCTION: Fatigue, anxiety and depression are very frequent symptoms in patients with rheumatoid arthritis (RA). GOALS: In this study we evaluated the influence of socioeconomic characteristics, therapy and comorbidities on the self-reported high fatigue, anxiety and depression in patients with RA. METHOD: Multicenter cross-sectional study was performed in 22 health institutions in Serbia during the period from April-August 2014 in population of older RA patients...
February 27, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28332858/modified-cognitive-behavioral-therapy-for-insomnia-in-depressed-adolescents-a-pilot-study
#9
Deirdre A Conroy, Alison M Czopp, Dawn M Dore-Stites, Richard R Dopp, Roseanne Armitage, Timothy F Hoban, J Todd Arnedt
OBJECTIVE/BACKGROUND: The purpose of the study was to pilot a five-week insomnia treatment in adolescents with major depressive disorder (MDD) and insomnia. This was an open-label trial of a modified-group cognitive behavioral therapy for insomnia (CBTI). PARTICIPANTS: Adolescents with MDD (n = 16; mean age = 17.3 +/- 1.7), characterized by the Children's Depression Rating Scale-Revised T-score ≥ 55 and insomnia, characterized by > 30 min to fall or return to sleep and an Insomnia Severity Index (ISI) score of ≥ 7 participated...
March 23, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28332714/phosphate-increase-during-fatigue-affects-crossbridge-kinetics-in-intact-mouse-muscle-at-physiological-temperature
#10
M Nocella, G Cecchi, B Colombini
Actomyosin ATP hydrolysis during muscle contraction releases inorganic phosphate, increasing [Pi ] in the myoplasm. Experiments in skinned fibres at low temperature (10-12°C) have shown that [Pi ] increase depresses isometric force and alters the kinetics of actomyosin interaction. However, Pi effects decrease with temperature and this raises the question of Pi role under physiological conditions. The present experiments were made to investigate this point. Intact fibre bundles isolated from the flexor digitorum brevis of C57BL/6 mice were stimulated with a series of tetanic contractions at 1...
March 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28332337/profiles-of-physical-function-physical-activity-and-sedentary-behavior-and-their-associations-with-mental-health-in-residents-of-assisted-living-facilities
#11
Saengryeol Park, Cecilie Thøgersen-Ntoumani, Nikos Ntoumanis, Andreas Stenling, Sally A M Fenton, Jet J C S Veldhuijzen van Zanten
BACKGROUND: The current study used latent profile analyses to identify classes of older participants based on physical health, physical function, light physical activity, moderate-to-vigorous physical activity, and sedentary behavior, and then examined differences in mental health between these classes. METHODS: Eighty-five residents (M = 77.5 years old, SD = 8.2) from assisted living facilities participated. Light physical activity, moderate-to-vigorous physical activity, and sedentary behavior were assessed by accelerometers, physical function was measured using different tasks (mobility, grip strength, and spirometry), and body mass index was calculated...
March 2017: Applied Psychology. Health and Well-being
https://www.readbyqxmd.com/read/28331743/psychiatric-symptoms-and-psychosocial-problems-in-patients-with-breast-cancer
#12
REVIEW
Filiz İzci, Ahmet Serkan İlgün, Ebru Fındıklı, Vahit Özmen
Cancer is a physical disease and also one of the leading clinical manifestations where psychosocial problems are prevalent. Psychosocial problems that these patients may have in the long run include anxiety, uneasiness, mourning, helplessness, fatigue, impairment of concentration, sleep disorders, mental and cognitive reservation, sexual dysfunction, infertility, psychological distress, and psychiatric disorders. Psychosocial problems have a nature of underpinning the emergence of psychological troubles. The prevalence of psychological disorders in patients with cancer range from 29% to 47%...
July 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28328717/perceived-sleep-quality-mood-states-and-their-relationship-with-performance-among-brazilian-elite-athletes-during-a-competitive-period
#13
Ricardo Brandt, Guilherme G Bevilacqua, Alexandro Andrade
Brandt, R, Bevilacqua, GG, and Andrade, A. Perceived sleep quality, mood states, and their relationship with performance among Brazilian elite athletes during a competitive period. J Strength Cond Res 31(4): 1033-1039, 2017-We described the perceived sleep quality and mood states of elite athletes during a competitive period, and clarified their relationship to athletes' sport performance. Participants were 576 Brazilian elite athletes (404 men and 172 women) of individual and team sports. Mood states were evaluated using the Brunel Mood Scale, whereas perceived sleep quality was evaluated using a single question ("How would you evaluate the quality of your sleep in the last few days?")...
April 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28327445/nine-differentially-expressed-genes-from-a-post-mortem-study-and-their-association-with-suicidal-status-in-a-sample-of-suicide-completers-attempters-and-controls
#14
Martina Balestri, Concetta Crisafulli, Luigi Donato, Ina Giegling, Raffaella Calati, Niki Antypa, Barbara Schneider, Dragan Marusic, Maria Eugenia Tarozzi, Dorjan Marusic, Metka Paragi, Annette M Hartmann, Bettina Konte, Agnese Marsano, Alessandro Serretti, Dan Rujescu
Several lines of evidence indicate that suicidal behaviour is partly heritable, with multiple genes implicated in its aetiology. We focused on nine genes (S100A13, EFEMP1, PCDHB5, PDGFRB, CDCA7L, SCN2B, PTPRR, MLC1 and ZFP36) which we previously detected as differentially expressed in the cortex of suicide victims compared to controls. We investigated 84 variants within these genes in 495 suicidal subjects (299 completers and 196 attempters) and 1513 controls (109 post-mortem and 1404 healthy). We evaluated associations with: 1) suicidal phenotype; 2) possible endophenotypes for suicidal behaviour...
March 10, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28324618/thermogelling-chitosan-lactate-hydrogel-improves-functional-recovery-after-a-c2-spinal-cord-hemisection-in-rat
#15
Katarzyna Nawrotek, Tanguy Marqueste, Zofia Modrzejewska, Roman Zarzycki, Agnieszka Rusak, Patrick Decherchi
The present study was designed to provide an appropriate micro-environment for regenerating axotomized neurons and proliferating/migrating cells. Because of its intrinsic permissive properties, biocompatibility and biodegradability, we chose to evaluate the therapeutic effectiveness of a chitosan-based biopolymer. The biomaterial toxicity was measured through in vitro test based on fibroblast cell survival on thermogelling chitosan lactate hydrogel substrate and then polymer was implanted into a C2 hemisection of the rat spinal cord...
March 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28324317/anxiety-and-depression-symptoms-and-migraine-a-symptom-based-approach-research
#16
Mario Fernando Prieto Peres, Juliane P P Mercante, Patricia R Tobo, Helder Kamei, Marcelo Eduardo Bigal
BACKGROUND: Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited information is available on how specific anxiety and depression symptoms are related to migraine. Symptoms-based approach, a current trend in mental health research, may improve our understanding in migraine comorbidity. The purpose of this study was to analyze how anxiety and depression aspects are related to migraine through a symptom-based approach...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28322161/the-use-of-methylphenidate-in-cancer-patients-a-review
#17
Beatrice Andrew, Chong Guan Ng, Nik Ruzyanei Nik Jaafar
BACKGROUND: One of the goals of cancer treatment is symptoms management especially at the end stage. The common symptoms in cancer include pain, fatigue, depression and cognitive dysfunction. The available treatment options for symptom management are limited. Methylphenidate, a psychostimulant, may be of benefit for these patients. In this report, we review the use of methylphenidate for symptoms control in cancer patients. METHOD: Electronic literature search on PubMed was conducted using the following keywords: methylphenidate, cancer, carcinoma, oncology, oncological and tumour...
March 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28321357/factors-associated-with-poststroke-anxiety-a-systematic-review-and-meta-analysis
#18
REVIEW
Francesca Wright, Simiao Wu, Ho-Yan Yvonne Chun, Gillian Mead
Background and Purpose. Anxiety affects 25% of stroke survivors. There are no effective treatments. Poststroke depression, prestroke anxiety and depression, locus of control, coping, confidence, fatigue, and sleep are factors that may be associated with poststroke anxiety and can potentially be targeted by therapy. We systematically reviewed the literature and performed a meta-analysis to identify associations with these factors. Methods. We searched electronic databases from January 2014 to July 2015 to complement a literature search performed from inception to May 2014...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28319509/a-high-preoperative-pain-and-symptom-profile-predicts-worse-pain-outcomes-for-children-after-spine-fusion-surgery
#19
Terri Voepel-Lewis, Michelle S Caird, Alan R Tait, Shobha Malviya, Frances A Farley, Ying Li, Matthew D Abbott, Tara van Veen, Afton L Hassett, Daniel J Clauw
BACKGROUND: Preoperative pain predicts persistent pain after spine fusion, yet little is understood about the nature of that pain, related symptoms, and how these symptoms relate to postoperative pain outcomes. This prospective study examined children's baseline pain and symptom profiles and the association between a high symptom profile and postoperative outcomes. METHODS: Seventy children (aged 10-17 years) scheduled for correction of idiopathic scoliosis completed pain and symptom surveys during their preoperative visit (ie, pain intensity [0-10 numeric rating scores], a pediatric version of the 2011 fibromyalgia survey criteria [including pain locations and symptom severity scale], neuropathic pain symptoms [painDETECT], and Patient-Reported Outcome Measurement System measures of fatigue, depression, function, pain interference, and pain catastrophizing)...
March 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28318414/the-prevalence-of-self-reported-premenstrual-symptoms-and-evaluation-of-regular-exercise-with-premenstrual-symptoms-among-female-employees-in-taiwan
#20
Su-Ying Tsai, Fu-Chen Kuo, Hsin-Chih Kuo, Li-Ling Liao
Few studies have focused on premenstrual symptoms in employees. This study explored the prevalence of premenstrual symptoms in 7,193 female employees aged 18-55 years in a large electronics manufacturer in Taiwan from August 2014 to December 2014 and examined whether regular exercise was associated with premenstrual symptoms. Information was collected on demographics, lifestyle, menstrual history, menstrual pain, and premenstrual symptoms. Half of the participants reported irregular menstruation; 79.4% reported a moderate menstruation amount, and half reported little impact of menstrual pain at work...
March 20, 2017: Women & Health
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