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Paulo F Almeida

Francis D O Ablan, B Logan Spaller, Kaitlyn I Abdo, Paulo F Almeida
Hundreds of cationic antimicrobial and cell-penetrating peptides (CPPs) form amphipathic α-helices when bound to lipid membranes. Here, we test two hypotheses for the differences in the ability of these peptides to translocate across membranes. The first, which we now call the hydrophobicity hypothesis, is that peptide translocation is determined by the Gibbs energy of insertion into the bilayer from the membrane interface. The second, which we call the charge-distribution hypothesis, is that translocation is determined by whether the distribution of cationic residues in the peptide can transiently stabilize a high-energy inserted intermediate by forming salt bridges to the phosphates of lipid headgroups...
October 18, 2016: Biophysical Journal
Diogo F Almeida, Rui B Ruben, João Folgado, Paulo R Fernandes, Emmanuel Audenaert, Benedict Verhegghe, Matthieu De Beule
Femur segmentation can be an important tool in orthopedic surgical planning. However, in order to overcome the need of an experienced user with extensive knowledge on the techniques, segmentation should be fully automatic. In this paper a new fully automatic femur segmentation method for CT images is presented. This method is also able to define automatically the medullary canal and performs well even in low resolution CT scans. Fully automatic femoral segmentation was performed adapting a template mesh of the femoral volume to medical images...
October 14, 2016: Medical Engineering & Physics
Mariah J King, Ashley L Bennett, Paulo F Almeida, Hee-Seung Lee
δ-lysin, secreted by a Gram-positive bacterium Staphylococcus aureus, is a 26-residue membrane active peptide that shares many common features with antimicrobial peptides (AMPs). However, it possesses a few unique features that differentiate itself from typical AMPs. In particular, δ-lysin has zero net charge, even though it has many charged residues, and it preferentially lyses eukaryotic cells over bacterial cells. Here, we present the results of coarse-grained molecular dynamics simulations of δ-lysin interacting with a zwitterionic membrane over a wide range of peptide concentrations...
October 6, 2016: Biochimica et Biophysica Acta
Maria-Cristina de C Brandileone, Rosemeire C Zanella, Samanta C G Almeida, Angela P Brandao, Ana F Ribeiro, Telma-Regina M P Carvalhanas, Helena Sato, Ana-Lúcia Andrade, Jennifer R Verani
In March 2010, Brazil introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in the routine infant immunization program using a 4-dose schedule and catch-up for children <23months. We investigated PCV10 effect on nasopharyngeal carriage with vaccine-type Streptococcus pneumoniae (Spn) and non-typeable Haemophilus influenzae (NTHi) among children in São Paulo city. Cross-sectional surveys were conducted in 2010 (baseline) and 2013 (post-PCV10). Healthy PCV-naïve children aged 12-23months were recruited from primary health centers during immunization campaigns...
September 28, 2016: Vaccine
Otávio T da Silva, César C de Almeida, Ricardo F Iglesio, Jessie M de Navarro, Manoel J Teixeira, Kleber P Duarte
BACKGROUND: In this article, the authors described their experience in microvascular decompression for trigeminal neuralgia. METHODS: The microvascular decompression technique used in the authors' institution is described in a step by step manner with some illustrative cases as well as a cadaver dissection to highlight the differences with other previously described techniques. RESULTS: Since 2013, 107 patients were operated in the Neurosurgery Division of the University of São Paulo using the described technique, with a shorter operative time and avoiding cerebellar retractor compared with classic techniques...
2016: Surgical Neurology International
Felipe F da Mota, Thalles V Lisboa, Breno X M da Costa, Fábio L de Queiroz, Eliane S Mansur, Rodrigo de Almeida Paiva, Paulo R França Neto
No abstract text is available yet for this article.
2016: Endoscopy
Bruno Mt Queridinha, Ricardo F Almeida, António Felino, Miguel de Araújo Nobre, Paulo Maló
PURPOSE: The purpose of this study was to compare the outcome of fixed partial prostheses in the posterior maxilla with two axially placed implants or one implant placed distally tilted and one axially placed implant following an immediate loading protocol. MATERIALS AND METHODS: A sample of 60 patients was divided into two groups-group 1: 30 patients rehabilitated with one axially placed implant and one implant placed distally tilted in the posterior maxilla; group 2: 30 patients rehabilitated with two axially placed implants in the posterior maxilla...
July 2016: International Journal of Oral & Maxillofacial Implants
Robin L Chazdon, Eben N Broadbent, Danaë M A Rozendaal, Frans Bongers, Angélica María Almeyda Zambrano, T Mitchell Aide, Patricia Balvanera, Justin M Becknell, Vanessa Boukili, Pedro H S Brancalion, Dylan Craven, Jarcilene S Almeida-Cortez, George A L Cabral, Ben de Jong, Julie S Denslow, Daisy H Dent, Saara J DeWalt, Juan M Dupuy, Sandra M Durán, Mario M Espírito-Santo, María C Fandino, Ricardo G César, Jefferson S Hall, José Luis Hernández-Stefanoni, Catarina C Jakovac, André B Junqueira, Deborah Kennard, Susan G Letcher, Madelon Lohbeck, Miguel Martínez-Ramos, Paulo Massoca, Jorge A Meave, Rita Mesquita, Francisco Mora, Rodrigo Muñoz, Robert Muscarella, Yule R F Nunes, Susana Ochoa-Gaona, Edith Orihuela-Belmonte, Marielos Peña-Claros, Eduardo A Pérez-García, Daniel Piotto, Jennifer S Powers, Jorge Rodríguez-Velazquez, Isabel Eunice Romero-Pérez, Jorge Ruíz, Juan G Saldarriaga, Arturo Sanchez-Azofeifa, Naomi B Schwartz, Marc K Steininger, Nathan G Swenson, Maria Uriarte, Michiel van Breugel, Hans van der Wal, Maria D M Veloso, Hans Vester, Ima Celia G Vieira, Tony Vizcarra Bentos, G Bruce Williamson, Lourens Poorter
Regrowth of tropical secondary forests following complete or nearly complete removal of forest vegetation actively stores carbon in aboveground biomass, partially counterbalancing carbon emissions from deforestation, forest degradation, burning of fossil fuels, and other anthropogenic sources. We estimate the age and spatial extent of lowland second-growth forests in the Latin American tropics and model their potential aboveground carbon accumulation over four decades. Our model shows that, in 2008, second-growth forests (1 to 60 years old) covered 2...
May 2016: Science Advances
Paulo S Carvalho, Leonardo R Almeida, João H Araújo Neto, Ana Carolina Q D Medina, Antonio C S Menezes, José E F Sousa, Solemar S Oliveira, Ademir J Camargo, Hamilton B Napolitano
A comprehensive investigation of anhydrous form of 3,4,5-Triacetoxybenzoic acid (TABA) is reported. Single crystal X-ray diffraction, Thermal analysis, Fourier Transform Infrared spectroscopy (FTIR) and DFT calculations were applied for TABA characterization. This anhydrous phase crystallizes in the triclinic [Formula: see text] space group (Z' = 1) and its packing shows a supramolecular motif in a classical [Formula: see text] ring formed by acid-acid groups association. The phase stability is accounted in terms of supramolecular architecture and its thermal behaviour...
2016: PloS One
Lauren M Ataman, Jhenifer K Rodrigues, Ricardo M Marinho, João P J Caetano, Maurício B Chehin, Eduardo L Alves da Motta, Paulo Serafini, Nao Suzuki, Tatsuro Furui, Seido Takae, Yodo Sugishita, Ken-Ichiro Morishige, Teresa Almeida-Santos, Cláudia Melo, Karen Buzaglo, Kate Irwin, W Hamish Wallace, Richard A Anderson, Roderick T Mitchell, Evelyn E Telfer, Satish K Adiga, Antoinette Anazodo, Catharyn Stern, Elizabeth Sullivan, Yasmin Jayasinghe, Lisa Orme, Richard Cohn, Rob McLachlan, Rebecca Deans, Franca Agresta, Brigitte Gerstl, William L Ledger, Rebecca L Robker, João M de Meneses E Silva, Lígia H F Melo E Silva, Franciele O Lunardi, Jung R Lee, Chang S Suh, Michael De Vos, Ellen Van Moer, Dominic Stoop, Veerle Vloeberghs, Johan Smitz, Herman Tournaye, Ludwig Wildt, Katharina Winkler-Crepaz, Claus Y Andersen, Brigid M Smith, Kristin Smith, Teresa K Woodruff
Fertility preservation in the cancer setting, known as oncofertility, is a field that requires cross-disciplinary interaction between physicians, basic scientists, clinical researchers, ethicists, lawyers, educators, and religious leaders. Funded by the National Institutes of Health, the Oncofertility Consortium (OC) was formed to be a scientifically grounded, transparent, and altruistic resource, both intellectual and monetary, for building this new field of practice capable of addressing the unique needs of young patients with cancer...
April 2016: Journal of Global Oncology
Késsia Suênia Fidelis de Mesquita-Guimarães, Iliana Ferraz Sabbatini, Cintia Guimarães de Almeida, Rodrigo Galo, Paulo Nelson-Filho, Maria Cristina Borsatto
Dental sealants are important for prevention of carious lesions, if they have good shear strength. The aim of this study was to evaluate the shear bond strength (SBS) of two sealants to saliva-contaminated and non-contaminated enamel with and without an intermediate adhesive layer underneath the sealant. Ninety flat enamel surfaces from human third molars were randomly assigned to 6 groups (n=15): F (control): Fluroshield(tm) sealant; EWB (control): Embrace(tm) WetBond(tm); SB/F: Single Bond adhesive system + F; SB/EWB, s-SB/F and s-SB/EWB...
May 2016: Brazilian Dental Journal
Thiago de Almeida Salles, Camila Zogbi, Thais Martins de Lima, Camila de Godoi Carneiro, Alexandre Teles Garcez, Hermes Vieira Barbeiro, Ednei Luiz Antonio, Leonardo Dos Santos, Alexandre da Costa Pereira, Paulo José Ferreira Tucci, Daniele de Paula Faria, Francisco Garcia Soriano, Adriana Castello Costa Girardi
Circulating dipeptidyl peptidase IV (DPPIV) activity correlates with cardiac dysfunction in humans and experimental heart failure (HF) models. Similarly, inflammatory markers are associated with poorer outcomes in HF patients. However, the contributions of DPPIV to inflammation in HF remain elusive. Therefore, this study aimed to investigate whether the cardioprotective effects of DPPIV inhibition after myocardial injury are accompanied by reduced cardiac inflammation, whether circulating DPPIV activity correlates with the levels of systemic inflammatory markers in HF patients, and whether leukocytes and/or splenocytes may be one of the sources of circulating DPPIV in HF...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Bernardete Weber, Ângela C Bersch-Ferreira, Camila R Torreglosa, Maria B Ross-Fernandes, Jacqueline T da Silva, Andrea P Galante, Enilda de Sousa Lara, Rosana P Costa, Rafael M Soares, Alexandre B Cavalcanti, Emilio H Moriguchi, Neide M Bruscato, Josiele Kesties, Lilian Vivian, Marina Schumacher, Waldemar de Carli, Luciano M Backes, Bruna R Reolão, Milena P Rodrigues, Dúnnia M B Baldissera, Glaucia S Tres, Hugo R K Lisbôa, João B J Bem, Jose B C Reolão, Keyla L A L Deucher, Maiara Cantarelli, Aline Lucion, Daniela Rampazzo, Vanessa Bertoni, Rosileide S Torres, Adriana O L Verríssimo, Aldair S Guterres, Andrea F R Cardos, Dalva B S Coutinho, Mayara G Negrão, Mônica F A Alencar, Priscila M Pinho, Socorro N A A Barbosa, Ana P P F Carvalho, Maria I S Taboada, Sheila A Pereira, Raul V Heyde, Francisca E Z Nagano, Rebecca Baumgartner, Fernanda P Resende, Ranata Tabalipa, Ana C Zanini, Michael J R Machado, Hevila Araujo, Maria L V Teixeira, Gabriela C Souza, Priccila Zuchinali, Bianca M Fracasso, Karen Ulliam, Marina Schumacher, Moara Pierotto, Thamires Hilário, Daniele M O Carlos, Cintia G N C Cordeiro, Daniele A Carvalho, Marília S Gonçalves, Valdiana B Vasconcelos, Rosa Bosquetti, Raira Pagano, Marcelo L P Romano, César A Jardim, Bernardo N A de Abreu, Aline Marcadenti, Alessandra R Schmitt, Angela M V Tavares, Christiane C Faria, Flávia M Silva, Jaqueline S Fink, Raquel M El Kik, Clarice F Prates, Cristiane S Vieira, Elaine F Adorne, Ellen H Magedanz, Fernanda L Chieza, Ingrid S Silva, Joise M Teixeira, Eduardo P Trescastro, Lívia A Pellegrini, Jéssika C Pinto, Cristina T Telles, Antonio C S Sousa, Andreza S Almeida, Ariane A Costa, José A C Carmo, Juliana T Silva, Luciana V S Alves, Saulo O C Sales, Maria E M Ramos, Marilia C S Lucas, Monica Damiani, Patricia C Cardoso, Salvador S Ramos, Clenise F Dantas, Amanda G Lopes, Ana M P Cabral, Ana C A Lucena, Auriene L Medeiros, Bernardino B Terceiro, Neuma M F S Leda, Sandra R D Baía, Josilene M F Pinheiro, Alexandra N Cassiano, Andressa N L Melo, Anny K O Cavalcanti, Camila V S Souza, Dayanna J M Queiroz, Hercilla N C F Farias, Larissa C F Souza, Letícia S Santos, Luana R M Lima, Meg S Hoffmann, Átala S Silva Ribeiro, Daniel F Vasconcelos, Eliane S Dutra, Marina K Ito, José A F Neto, Alexsandro F Santos, Rosângela M L Sousa, Luciana Pereira P Dias, Maria T M A Lima, Victor G Modanesi, Adriana F Teixeira, Luciana C N C D Estrada, Paulo V G Modanesi, Adriana B L Gomes, Bárbara R S Rocha, Cristina Teti, Marta M David, Bruna M Palácio, Délcio G S Junior, Érica H S Faria, Michelle C F Oliveira, Rose M Uehara, Sandramara Sasso, Annie S B Moreira, Ana C A H Cadinha, Carla W M Pinto, Mariana P Castilhos, Mariana Costa, Cristiane Kovacs, Daniel Magnoni, Quênia Silva, Michele F C A Germini, Renata A da Silva, Aline S Monteiro, Karina G Dos Santos, Priscila Moreira, Fernanda C Amparo, Catharina C J Paiva, Soraia Poloni, Diana S Russo, Izabele V Silveira, Maria A Moraes, Mirena Boklis, Quinto I Cardoso, Annie S B Moreira, Aline M S Damaceno, Elisa M Santos, Glauber M Dias, Cláudia P S Pinho, Adrilene C Cavalcanti, Amanda S Bezerra, Andrey V Queiroga, Isa G Rodrigues, Tallita V Leal, Viviane Sahade, Daniele A Amaral, Diana S Souza, Givaldo A Araújo, Karine Curvello, Manuella Heine, Marília M S Barretto, Nailson A Reis, Sandra M L Vasconcelos, Danielly C Vieira, Francisco A Costa, Jessica M S Fontes, Juvenal G C Neto, Laís N P Navarro, Raphaela C Ferreira, Patrícia M Marinho, Renata Torres Abib, Aline Longo, Eduardo G Bertoldi, Lauren S Ferreira, Lúcia R Borges, Norlai A Azevedo, Celma M Martins, Juliana T Kato, Maria C O Izar, Marina T Asoo, Mariana D de Capitani, Valéria A Machado, Waléria T Fonzar, Sônia L Pinto, Kellen C Silva, Lúcia H A Gratão, Sheila D Machado, Susane R U de Oliveira, Josefina Bressan, Ana P S Caldas, Hatanne C F M Lima, Helen H M Hermsdorff, Tânia M Saldanha, Sílvia E Priore, Naoel H Feres, Adila de Queiroz Neves, Loanda M G Cheim, Nilma F Silva, Silvia R L Reis, Andreza M Penafort, Ana Paula O de Queirós, Geysa M N Farias, Mônica L P de Los Santos, Cíntia L Ambrozio, Cirília N Camejo, Cristiano P Dos Santos, Gabriela S Schirmann, Jorge L Boemo, Rosane E C Oliveira, Súsi M B Lima, Vera M S Bortolini, Cristina H Matos, Claiza Barretta, Clarice M Specht, Simone R de Souza, Cristina S Arruda, Priscila A Rodrigues, Otávio Berwanger
No abstract text is available yet for this article.
May 2016: American Heart Journal
Rodrigo L Moura, Gilberto M Amado-Filho, Fernando C Moraes, Poliana S Brasileiro, Paulo S Salomon, Michel M Mahiques, Alex C Bastos, Marcelo G Almeida, Jomar M Silva, Beatriz F Araujo, Frederico P Brito, Thiago P Rangel, Braulio C V Oliveira, Ricardo G Bahia, Rodolfo P Paranhos, Rodolfo J S Dias, Eduardo Siegle, Alberto G Figueiredo, Renato C Pereira, Camille V Leal, Eduardo Hajdu, Nils E Asp, Gustavo B Gregoracci, Sigrid Neumann-Leitão, Patricia L Yager, Ronaldo B Francini-Filho, Adriana Fróes, Mariana Campeão, Bruno S Silva, Ana P B Moreira, Louisi Oliveira, Ana C Soares, Lais Araujo, Nara L Oliveira, João B Teixeira, Rogerio A B Valle, Cristiane C Thompson, Carlos E Rezende, Fabiano L Thompson
Large rivers create major gaps in reef distribution along tropical shelves. The Amazon River represents 20% of the global riverine discharge to the ocean, generating up to a 1.3 × 10(6)-km(2) plume, and extensive muddy bottoms in the equatorial margin of South America. As a result, a wide area of the tropical North Atlantic is heavily affected in terms of salinity, pH, light penetration, and sedimentation. Such unfavorable conditions were thought to imprint a major gap in Western Atlantic reefs. We present an extensive carbonate system off the Amazon mouth, underneath the river plume...
April 2016: Science Advances
Aline C Dall-Orsoletta, João Gabriel R Almeida, Paulo C F Carvalho, Jean V Savian, Henrique M N Ribeiro-Filho
The inclusion of grazed pasture in dairy feeding systems based on a total mixed ration (TMR) reduces feed costs, benefits herd health, and reduces environmental impact. The present study aimed to evaluate the effect of ryegrass pasture combined with a partial TMR on enteric methane emissions, dry matter intake (DMI), and performance of dairy cows from mid to late lactation. The experimental treatments included 100% TMR (control), partial TMR + 6h of continuous grazing (0900-1500 h), and partial TMR + 6h of grazing that was divided into 2 periods of 3h each that took place after milking (0900-1200 h; 1530-1830 h)...
June 2016: Journal of Dairy Science
Camilla S Almeida, Paulo F Cristaldo, Daniela F Florencio, Nayara G Cruz, Abraão A Santos, Alexandre P Oliveira, Alisson S Santana, Efrem J M Ribeiro, Ana P S Lima, Leandro Bacci, Ana P A Araújo
A range of behavioural strategies and sensory abilities allows animals to minimize costs involved in food search. By building a network of tunnels and presenting a large number of soldiers (i.e., trophically dependent individuals), Nasutitermes spp. termites feature behaviours that imply additional costs during this process. Here we evaluated N. aff. coxipoensis foraging strategies focusing on the role of soldiers during foraging. Field experiments were carried out via nests transplantation to dune areas, and laboratory experiments evaluated termite responses to sternal gland chemical signals from workers and soldiers...
May 2016: Behavioural Processes
Mauricio L Barreto, Manoel Barral-Netto, Rodrigo Stabeli, Naomar Almeida-Filho, Pedro F C Vasconcelos, Mauro Teixeira, Paulo Buss, Paulo E Gadelha
No abstract text is available yet for this article.
March 5, 2016: Lancet
Thaís Aparecida Vieira Reis, Andrêssa Silvino Ferreira Assis, Daniel Almeida do Valle, Vívian Honorato Barletta, Iná Pires de Carvalho, Tatiana Lundgren Rose, Silvana Augusta Rodrigues Portes, José Paulo Gagliardi Leite, Maria Luzia da Rosa e Silva
Human adenovirus species F (HAdV-F) type 40 and 41 are commonly associated with acute diarrheal disease (ADD) across the world. Despite being the largest state in southeastern Brazil and having the second largest number of inhabitants, there is no information in the State of Minas Gerais regarding the role of HAdV-F in the etiology of ADD. This study was performed to determine the prevalence, to verify the epidemiological aspects of infection, and to characterize the strains of human adenoviruses (HAdV) detected...
January 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Lourens Poorter, Frans Bongers, T Mitchell Aide, Angélica M Almeyda Zambrano, Patricia Balvanera, Justin M Becknell, Vanessa Boukili, Pedro H S Brancalion, Eben N Broadbent, Robin L Chazdon, Dylan Craven, Jarcilene S de Almeida-Cortez, George A L Cabral, Ben H J de Jong, Julie S Denslow, Daisy H Dent, Saara J DeWalt, Juan M Dupuy, Sandra M Durán, Mario M Espírito-Santo, María C Fandino, Ricardo G César, Jefferson S Hall, José Luis Hernandez-Stefanoni, Catarina C Jakovac, André B Junqueira, Deborah Kennard, Susan G Letcher, Juan-Carlos Licona, Madelon Lohbeck, Erika Marín-Spiotta, Miguel Martínez-Ramos, Paulo Massoca, Jorge A Meave, Rita Mesquita, Francisco Mora, Rodrigo Muñoz, Robert Muscarella, Yule R F Nunes, Susana Ochoa-Gaona, Alexandre A de Oliveira, Edith Orihuela-Belmonte, Marielos Peña-Claros, Eduardo A Pérez-García, Daniel Piotto, Jennifer S Powers, Jorge Rodríguez-Velázquez, I Eunice Romero-Pérez, Jorge Ruíz, Juan G Saldarriaga, Arturo Sanchez-Azofeifa, Naomi B Schwartz, Marc K Steininger, Nathan G Swenson, Marisol Toledo, Maria Uriarte, Michiel van Breugel, Hans van der Wal, Maria D M Veloso, Hans F M Vester, Alberto Vicentini, Ima C G Vieira, Tony Vizcarra Bentos, G Bruce Williamson, Danaë M A Rozendaal
Land-use change occurs nowhere more rapidly than in the tropics, where the imbalance between deforestation and forest regrowth has large consequences for the global carbon cycle. However, considerable uncertainty remains about the rate of biomass recovery in secondary forests, and how these rates are influenced by climate, landscape, and prior land use. Here we analyse aboveground biomass recovery during secondary succession in 45 forest sites and about 1,500 forest plots covering the major environmental gradients in the Neotropics...
February 11, 2016: Nature
Luciana G da S Souza, Macia C S Almeida, Telma L G Lemos, Paulo R V Ribeiro, Edy S de Brito, Vera L M Silva, Artur M S Silva, Raimundo Braz-Filho, José G M Costa, Fábio F G Rodrigues, Francisco S Barreto, Manoel O de Moraes
Biflorin 1 is a biologically active quinone, isolated from Capraria biflora. Five new biflorin-based nitrogen derivatives were synthesized, of which two were mixtures of (E)- and (Z)- isomers: (Z)-2a, (Z)-2b, (Z)-3a, (Z)- and (E)-3b, (Z)- and (E)-3c. The antibacterial activity was investigated using the microdilution method for determining the minimum inhibitory concentration (MIC) against six bacterial strains. Tests have shown that these derivatives have potential against all bacterial strains. The cytotoxic activity was also evaluated against three strains of cancer cells, but none of the derivatives showed activity...
January 15, 2016: Bioorganic & Medicinal Chemistry Letters
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