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Paulo F Almeida

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https://www.readbyqxmd.com/read/29187682/bacterial-glycerol-oxidation-coupled-to-sulfate-reduction-at-neutral-and-acidic-ph
#1
Sidnei C Santos, Martin G Liebensteiner, Antonie H van Gelder, Mauricio R Dimitrov, Paulo F Almeida, Cristina M Quintella, Alfons J M Stams, Irene Sánchez-Andrea
Glycerol is a main co-product of biodiesel production. Crude glycerol may serve as a cheap and attractive substrate in biotechnological applications, e.g. for the production of valuable chemicals or as an electron donor for reduction processes. In this work, sulfate reduction with glycerol was studied at neutral and acidic pH using bioreactor sludge samples and Tinto River sediments as a source of inoculum, respectively. Communities of sulfate-reducing bacteria (SRB) and fermentative bacteria were co-enriched at both pH values...
November 29, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/29170530/identification-and-analysis-of-seven-effector-protein-families-with-different-adaptive-and-evolutionary-histories-in-plant-associated-members-of-the-xanthomonadaceae
#2
Renata de A B Assis, Lorraine Cristina Polloni, José S L Patané, Shalabh Thakur, Érica B Felestrino, Julio Diaz-Caballero, Luciano Antonio Digiampietri, Luiz Ricardo Goulart, Nalvo F Almeida, Rafael Nascimento, Abhaya M Dandekar, Paulo A Zaini, João C Setubal, David S Guttman, Leandro Marcio Moreira
The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to this family, with a focus on identifying proteins enriched in phytopathogens that could explain the lifestyle and the ability to infect plants. Using a computational approach, we identified seven phytopathogen-enriched protein families putatively secreted by type II secretory system: PheA (CM-sec), LipA/LesA, VirK, and four families involved in N-glycan degradation, NixE, NixF, NixL, and FucA1...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29130685/daptomycin-phosphatidylglycerol-domains-in-lipid-membranes
#3
Mark A Kreutzberger, Antje Pokorny, Paulo F Almeida
Daptomycin is an acidic, 13-amino acid, cyclic polypeptide that contains a number of nonproteinogenic residues and is modified at its N-terminus with a decanoyl chain. It has been in clinical use since 2003 against selected drug-resistant Staphylococcus aureus and Enterococcus spp infections. In vitro, daptomycin is active against Gram-positive pathogens at low concentrations but its antibiotic activity depends critically on the presence of calcium ions. This dependence has been thought to arise from binding of one or two Ca(2+) ions to daptomycin as a required step in its interaction with the bacterial membrane...
November 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29053913/morphological-changes-of-the-internal-carotid-artery-prevalence-and-characteristics-a-clinical-and-ultrasonographic-study-in-a-series-of-19-804-patients-over-25-years-old
#4
H F G Martins, A Mayer, P Batista, F Soares, V Almeida, A J Pedro, V Oliveira
BACKGROUND AND PURPOSE: Morphological changes of the internal carotid arteries (McICA) are frequently found during cervical ultrasound studies. However, the etiology of McICA remains controversial. During this study, the prevalence and demographic characteristics of McICA, such as kinking, coiling or looping identified by Doppler ultrasound, were analysed and its relationship with vascular risk factors and stroke was assessed. METHODS: A retrospective study was performed by analysing 19 804 patients who were subjected to cervical ultrasonographic study between January 2000 and June 2012...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28867316/endoscopic-endonasal-surgery-for-treatment-of-pituitary-apoplexy-16-years-of-experience-in-a-specialized-pituitary-center-endoscopic-surgery-for-pituitary-apoplexy
#5
Jackson A Gondim, Lucas Alverne F de Albuquerque, Joao Paulo Almeida, Tania Bulcao, Erica Gomes, Michele Schops, Raquel Vasconcelos, Flora da Paz, Sergio Botelho Guimarães
OBJECTIVE: Symptomatic pituitary apoplexy is a rare but life-threatening condition caused by sudden hemorrhage or infarction of a pituitary adenoma. In the current study, we aim to evaluate the clinical presentation, management and clinical outcomes in a cohort of patients who were treated for this condition in our center in the last 16 years. METHODS: We performed a retrospective analysis of all patients who underwent endoscopic endonasal surgery for treatment of symptomatic pituitary apoplexy between 2001 and 2016 in our center...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28838147/specific-biomarkers-associated-with-neurological-complications-and-congenital-central-nervous-system-abnormalities-from-zika-virus-infected-patients-in-brazil
#6
Yiu-Wing Kam, Juliana Almeida Leite, Fok-Moon Lum, Jeslin J L Tan, Bernett Lee, Carla C Judice, Daniel Augusto de Toledo Teixeira, Robert Andreata-Santos, Marco A Vinolo, Rodrigo Angerami, Mariangela Ribeiro Resende, Andre Ricardo Ribas Freitas, Eliana Amaral, Renato Passini Junior, Maria Laura Costa, José Paulo Guida, Clarice Weis Arns, Luis Carlos S Ferreira, Laurent Rénia, Jose Luiz Proença-Modena, Lisa F P Ng, Fabio T M Costa
Background: Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations. Methods: We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult patients from Campinas, Brazil. These patients included 6 pregnant women who later delivered during the course of this study. Clinical observations were recorded during hospitalization...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28834711/and-yet-it-moves
#7
Paulo F Almeida
No abstract text is available yet for this article.
August 22, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28741872/breast-disease-in-men-in-metropolitan-s%C3%A3-o-paulo-brazil
#8
Renata Thaís de Almeida Barbosa, Maria Auxiliadora F Vertamatti, Claudia Arab, Tânia Brusque Crocetta, Ricardo Lencioni Mazzei, Ivo Carelli Filho, Ricardo Faure, Izabella Brandão Mendes, Luiz Carlos de Abreu
Although rare, breast cancer in males represents 1% of all cancer in men, and has shown increasing incidence in 25 years. To analyze age, gender, type of procedure performed and diagnosis of all cases of breast diseases in a public hospital in Sao Paulo, Brazil, with special focus on men. Cross-sectional study of breast surgery in 2010-2014 at Hospital Municipal Universitario de Sao Bernardo do Campo, Brazil. In the period 999 breast surgery were carried out. Patients with benign diseases were about 30 years old and patients with malignant diseases were over 50...
July 25, 2017: Breast Journal
https://www.readbyqxmd.com/read/28732311/solid-and-aqueous-magnetoliposomes-as-nanocarriers-for-a-new-potential-drug-active-against-breast-cancer
#9
Ana Rita O Rodrigues, Pedro M F Mendes, Pedro M L Silva, V A Machado, Bernardo G Almeida, J P Araújo, Maria-João R P Queiroz, Elisabete M S Castanheira, Paulo J G Coutinho
Iron oxide nanoparticles, with diameters around 12nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7Oe and a blocking temperature of 118K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane...
October 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28693539/genomic-prediction-in-contrast-to-a-genome-wide-association-study-in-explaining-heritable-variation-of-complex-growth-traits-in-breeding-populations-of-eucalyptus
#10
Bárbara S F Müller, Leandro G Neves, Janeo E de Almeida Filho, Márcio F R Resende, Patricio R Muñoz, Paulo E T Dos Santos, Estefano Paludzyszyn Filho, Matias Kirst, Dario Grattapaglia
BACKGROUND: The advent of high-throughput genotyping technologies coupled to genomic prediction methods established a new paradigm to integrate genomics and breeding. We carried out whole-genome prediction and contrasted it to a genome-wide association study (GWAS) for growth traits in breeding populations of Eucalyptus benthamii (n =505) and Eucalyptus pellita (n =732). Both species are of increasing commercial interest for the development of germplasm adapted to environmental stresses...
July 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28654663/two-sides-of-a-coin-effects-of-climate-change-on-the-native-and-non-native-distribution-of-colossoma-macropomum-in-south-america
#11
Taise M Lopes, Dayani Bailly, Bia A Almeida, Natália C L Santos, Barbara C G Gimenez, Guilherme O Landgraf, Paulo C L Sales, Matheus S Lima-Ribeiro, Fernanda A S Cassemiro, Thiago F Rangel, José A F Diniz-Filho, Angelo A Agostinho, Luiz C Gomes
Climate change and species invasions interact in nature, disrupting biological communities. Based on this knowledge, we simultaneously assessed the effects of climate change on the native distribution of the Amazonian fish Colossoma macropomum as well as on its invasiveness across river basins of South America, using ecological niche modeling. We used six niche models within the ensemble forecast context to predict the geographical distribution of C. macropomum for the present time, 2050 and 2080. Given that this species has been continuously introduced into non-native South American basins by fish farming activities, we added the locations of C...
2017: PloS One
https://www.readbyqxmd.com/read/28646200/mesenchymal-stem-cells-secretome-induced-axonal-outgrowth-is-mediated-by-bdnf
#12
Luís F Martins, Rui O Costa, Joana R Pedro, Paulo Aguiar, Sofia C Serra, Fabio G Teixeira, Nuno Sousa, António J Salgado, Ramiro D Almeida
Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair. However, MSCs grafting present disadvantages, such as, a high number of cells required for transplantation and low survival rate when transplanted into the central nervous system (CNS). In line with this, MSCs secretome which present on its composition a wide range of molecules (neurotrophins, cytokines) and microvesicles, can be a solution to surpass these problems...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28571975/synthesis-spectroscopic-characterization-and-biological-evaluation-of-unsymmetrical-aminosquarylium-cyanine-dyes
#13
Sofia Friães, Amélia M Silva, Renato E Boto, Diana Ferreira, José R Fernandes, Eliana B Souto, Paulo Almeida, Luis F Vieira Ferreira, Lucinda V Reis
New unsymmetrical aminosquarylium cyanine dyes were synthesized and their potential as photosensitizers evaluated. New dyes, derived from benzothiazole and quinoline, were prepared by nucleophilic substitution of the corresponding O-methylated, the key intermediate that was obtained by methylation with CF3SO3CH3 of the related zwitterionic unsymmetrical dye, with ammonia and methylamine, respectively. All three news dyes herein described displayed intense and narrow bands in the Vis/NIR region (693-714nm) and their singlet oxygen formation quantum yields ranged from 0...
July 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28553225/cardioprotective-action-of-ginkgo-biloba-extract-against-sustained-%C3%AE-adrenergic-stimulation-occurs-via-activation-of-m2-no-pathway
#14
Thássio R R Mesquita, Itamar C G de Jesus, Jucilene F Dos Santos, Grace K M de Almeida, Carla M L de Vasconcelos, Silvia Guatimosim, Fabrício N Macedo, Robervan V Dos Santos, José E R de Menezes-Filho, Rodrigo Miguel-Dos-Santos, Paulo T D Matos, Sérgio Scalzo, Valter J Santana-Filho, Ricardo L C Albuquerque-Júnior, Rose N Pereira-Filho, Sandra Lauton-Santos
Ginkgo biloba is the most popular phytotherapic agent used worldwide for treatment of several human disorders. However, the mechanisms involved in the protective actions of Ginkgo biloba on cardiovascular diseases remain poorly elucidated. Taking into account recent studies showing beneficial actions of cholinergic signaling in the heart and the cholinergic hypothesis of Ginkgo biloba-mediated neuroprotection, we aimed to investigate whether Ginkgo biloba extract (GBE) promotes cardioprotection via activation of cholinergic signaling in a model of isoproterenol-induced cardiac hypertrophy...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28522008/chitosan-chondroitin-sulfate-hydrogels-prepared-in-hmim-hso4-ionic-liquid
#15
Cátia S Nunes, Kessily B Rufato, Paulo R Souza, Elizângela A M S de Almeida, Michael J V da Silva, Débora B Scariot, Celso V Nakamura, Fernanda A Rosa, Alessandro F Martins, Edvani C Muniz
[Hmim][HSO4] ionic liquid (IL) and bio-renewable sources as chitosan (CHT) and chondroitin sulfate (CS) were used to yield hydrogel-based materials (CHT/CS). The use of IL to solubilize both polysaccharides was considered an innovative way based on "green chemistry" principle, aiming the production of CHT/CS blended systems. CHT/CS hydrogels were carried out in homogeneous medium from short dissolution times. The hydrogels were characterized and achieved with excellent stabilities (in the 1.2-10pH range), larger swelling capacities, as well as devoid of cytotoxicity towards the normal VERO and diseased HT29 cells...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28454763/sources-and-distribution-of-polycyclic-aromatic-hydrocarbons-pahs-and-organic-matter-in-surface-sediments-of-an-estuary-under-petroleum-activity-influence-todos-os-santos-bay-brazil
#16
Rodrigo A Nascimento, Marcos de Almeida, Narayana C F Escobar, Sergio L C Ferreira, Jefferson Mortatti, Antônio F S Queiroz
The present study evaluated the origin and distribution of polycyclic aromatic hydrocarbons (PAHs) and the organic matter (OM) in the surface sediment of the São Paulo River estuary, Todos os Santos Bay (TSB), Brazil. The samples were collected in the rainy (CP1) and the dry (CP2) seasons. We analyzed the 16 PAHs from the United States Environmental Protection Agency (US EPA) priority pollutant list, total organic carbon (TOC), total nitrogen (N), and stable carbon isotope (δ(13)C). The total concentration of PAHs ranged from 11...
April 25, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28437446/solid-state-characterization-and-theoretical-study-of-non-linear-optical-properties-of-a-fluoro-n-acylhydrazide-derivative
#17
Rosemberg F N Rodrigues, Leonardo R Almeida, Florisberto G Dos Santos, Paulo S Carvalho, Wanderson C de Souza, Kleber S Moreira, Gilberto L B de Aquino, Clodoaldo Valverde, Hamilton B Napolitano, Basílio Baseia
In this work we determine the linear and non-linear optical properties of a Fluoro-N-Acylhydrazide derivative (FBHZ), using a combined supermolecule approach and an iterative scheme of electrostatic polarization, where the atoms of neighbouring molecules are represented by point charges. Our results for non-linear optics (NLO) are comparable to those found experimentally, suggesting that FBHZ constitutes an attractive object for future studies and for use as an interesting material for third-order NLO applications...
2017: PloS One
https://www.readbyqxmd.com/read/28435911/is-cell-salvage-cost-effective-in-posterior-arthrodesis-for-adolescent-idiopathic-scoliosis-in-the-public-health-system
#18
José A A Oliveira, Fernando A M Façanha Filho, Francisco V Fernandes, Paulo C Almeida, Vládia F de Oliveira, Saulo R Lima Verde
BACKGROUND: To evaluate the efficacy and cost-effectiveness of cell salvage (CS) in reducing allogeneic transfusion in patients undergoing surgery for idiopathic scoliosis. METHODS: A case-control study with 42 patients with adolescent idiopathic scoliosis (AIS), submitted to posterior arthrodesis with instrumentation from 8/2008 to 12/2014 at the General Hospital of Fortaleza, Brazil. CS was used in 27 patients and not used in 15. The data was processed using the SPSS 20...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28327261/sex-differences-in-pediatric-dental-pain-perception
#19
Gabriela F Almeida, Daniele L Longo, Mariana Trevizan, Fabrício K de Carvalho, Paulo Nelson-Filho, Erika C Küchler, Alexandra M Queiroz
PURPOSE: To evaluate sex-related differences in dental pain perception in children. METHODS: Fifty-two children who received a dental procedure with local anesthesia were selected to participate. Pain perception levels were assessed with the Wong-Baker FACES Pain Rating Scale. Twenty-four and 48 hours following the procedure, the parents were contacted by phone for a verbal survey to assess their child's postoperative pain. Age, type of dental procedure, and behavior were also evaluated as covariables...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28240141/preparation-characterization-and-biocompatibility-studies-of-thermoresponsive-eyedrops-based-on-the-combination-of-nanostructured-lipid-carriers-nlc-and-the-polymer-pluronic-f-127-for-controlled-delivery-of-ibuprofen
#20
Hugo Almeida, Paulo Lobão, Christian Frigerio, Joel Fonseca, Renata Silva, José Manuel Sousa Lobo, Maria Helena Amaral
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs. OBJECTIVE: The aim of this study was to prepare thermoresponsive eyedrops based on the combination of lipid nanoparticles and a thermoresponsive polymer with mucomimetic properties (Pluronic® F-127). MATERIALS AND METHODS: NLCi dispersions were prepared based on the melt-emulsification and ultrasonication technique...
May 2017: Pharmaceutical Development and Technology
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