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Paulo Almeida

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https://www.readbyqxmd.com/read/28626969/different-patterns-of-expression-of-cell-cycle-control-and-local-invasion-related-proteins-in-oral-squamous-cell-carcinoma-affecting-young-patients
#1
Marisol Miranda Galvis, Alan Roger Santos-Silva, Juscelino Freitas Jardim, Felipe Paiva Fonseca, Marcio A Lopes, Oslei P Almeida, Clóvis A Lópes Pinto, Estela Kaminagakura, Iris Sawazaki-Calone, Paul M Speight, Luiz Paulo Kowalski
Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide and the clinical and behavioral characteristics of tumors in this group are controversial and the literature shows divergent results PURPOSE: To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤ 40 years old) METHODS: A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs...
June 19, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28624159/from-the-laboratory-to-the-field-updating-capacity-building-in-medical-entomology
#2
Antonio Paulo Gouveia Almeida, Florence Fouque, Pascal Launois, Carla A Sousa, Henrique Silveira
Training and innovation in the field of medical entomology are essential to mitigate the burden of vector-borne diseases globally. However, there is a shortage of medical entomologists worldwide, and there are large discrepancies in capacity building in this field. In this article, we discuss the current situation, what is needed from the medical entomologist of today, and how we can bridge this gap.
June 14, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28614734/multifunctional-magnetic-responsive-hydrogels-to-engineer-tendon-to-bone-interface
#3
Elsa D Silva, Pedro S Babo, Raquel Costa-Almeida, Rui M A Domingues, Bárbara B Mendes, Elvira Paz, Paulo Freitas, Márcia T Rodrigues, Pedro L Granja, Manuela E Gomes
Photocrosslinkable magnetic hydrogels are attracting great interest for tissue engineering strategies due to their versatility and multifunctionality, including their remote controllability ex vivo, thus enabling engineering complex tissue interfaces. This study reports the development of a photocrosslinkable magnetic responsive hydrogel made of methacrylated chondroitin sulfate (MA-CS) enriched with platelet lysate (PL) with tunable features, envisioning their application in tendon-to-bone interface. MA-CS coated iron-based magnetic nanoparticles were incorporated to provide magnetic responsiveness to the hydrogel...
June 11, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28609760/epidemiology-of-acne-vulgaris-in-18-year-old-male-army-conscripts-in-a-south-brazilian-city
#4
Rodrigo Pereira Duquia, Iná da Silva Dos Santos, Hiram de Almeida, Paulo Ricardo Martins Souza, Juliano de Avelar Breunig, Christos C Zouboulis
BACKGROUND: Prevalence of acne varies worldwide. Several factors (age, skin color, body fat, diet, and smoking) have been investigated as risk factors. OBJECTIVE: A total of 2,201 18-year-old males living in Pelotas, South Brazil, were evaluated in order to examine the prevalence of acne and associated factors. METHODS: A cross-sectional population-based study was conducted. A dermatologist performed the clinical examination of the face and trunk for identification of acne lesions...
June 14, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28602744/prevalence-and-factors-associated-with-neck-pain-a-population-based-study
#5
Caio Vitor Dos Santos Genebra, Nicoly Machado Maciel, Thiago Paulo Frascareli Bento, Sandra Fiorelli Almeida Penteado Simeão, Alberto De Vitta
BACKGROUND: Neck pain is a musculoskeletal condition with high prevalence that may affect the physical, social, and psychological aspects of the individual, contributing to the increase in costs in society and business. OBJECTIVE: To determine the prevalence of neck pain and associated factors in a population-based sample of adults aged 20 and more. METHODS: Cross-sectional study based on a population survey. A total number of 600 individuals were interviewed in their homes, and the following data were collected: (1) participant characteristics (demographic, socioeconomic, and work-related aspects) using a pre-coded questionnaire; (2) physical activity level using the IPAQ; and (3) musculoskeletal symptoms using the Nordic questionnaire...
May 20, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28597948/identification-of-a-carbonized-body-using-implanted-surgical-plates-the-importance-of-computed-tomography
#6
Vanessa Moreira Andrade, Christian Abreu Stibich, Paulo Maurício de Santa Martha, Casimiro Abreu Possante de Almeida, Andrea de Castro Domingos Vieira
In addition to clinical examination, forensic odontologists can use diagnostic imaging as an auxiliary method for identification. This paper reports a case where forensic odontologists from the Afrânio Peixoto Legal Medicine Institute in Rio de Janeiro (Brazil) positively identified a carbonized and partially calcined body using oral and maxillofacial imaging. The cadaver showed several metallic plates fixed with metallic screws on bones of the neurocranium and viscerocranium. Family members provided spiral computed tomography scans of the skull and a panoramic radiograph that were acquired after an accident that required surgical procedures...
June 9, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28597314/deltamethrin-as-inductor-agent-of-precocious-ovarian-degeneration-in-rhipicephalus-sanguineus-s-l-acari-ixodidae-ticks
#7
Maria Izabel Camargo-Mathias, Natalia Rubio Claret Pereira, Camila da Silva Reis, Cristiane Regina de Almeida, Douglas Rodrigo Dos Santos Mendes, Giselle Bezerra de Araújo, Lays Postali, Tober Figueroa, Allan Roberto Fernandes Ferreira, Juan Parente Santos, Patrícia Rosa de Oliveira
The cosmopolitan species Rhipicephalus sanguineus s.l. is one of the most widely distributed ticks all over the world. These ectoparasites are vectors of several pathogens and cause significant direct damage to their hosts. The biological success of these ectoparasites has been attributed to their ovaries and salivary glands, organs that ensure their survival in various environmental conditions. The importance of the ovaries in ticks is that, after mating, the individuals are able to lay approximately three thousand eggs...
June 8, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28597068/genetic-diversity-of-human-papillomavirus-types-35-45-and-58-in-cervical-cancer-in-brazil
#8
Diogo Lisbôa Basto, João Paulo Vidal, Valéria Barbosa Pontes, Shayany Pinto Felix, Laine Celestino Pinto, Bruno Moreira Soares, Luis Felipe Martins, Flávia Miranda Correa, Raquel Carvalho Montenegro, Cláudia Bessa Pereira Chaves, Liz Maria Almeida, Miguel Ângelo Martins Moreira
In Brazil, most studies of intra-type variants of human papillomavirus (HPV) have focused on HPV16 and HPV18, but other high-risk HPV types have not been studied. Here, we report the prevalence of lineages and variants of HPV35, HPV45 and HPV58 in cervical cancers from the Amazonian and Southeast Brazilian regions. The most frequent sublineages were A1 for HPV35, B2 for HPV45, and A2 for HPV58. The Southeast region had a higher frequency of the B2 sublineage of HPV45, and for HPV35, the genetic and nucleotide sequence diversity were higher in the Southeast region, suggesting that regional factors are influencing the diversity and lineage prevalence...
June 9, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28591354/inequalities-in-healthy-life-expectancy-by-federated-states
#9
Célia Landmann Szwarcwald, Dália Elena Romero Montilla, Aline Pinto Marques, Giseli Nogueira Damacena, Wanessa da Silva de Almeida, Deborah Carvalho Malta
OBJECTIVES: To estimate the healthy life expectancy at 60 years by sex and Federated States and to investigate geographical inequalities by socioeconomic status. METHODS: Healthy life expectancy was estimated by the Sullivan method, based on the information of the National Survey on Health, 2013. Three criteria were adopted for the definition of "unhealthy state": self-assessment of bad health, functionality for performing the activities of daily living, and the presence of noncommunicable disease with intense degree of limitation...
June 1, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28591309/detection-and-molecular-characterisation-of-a-diagnosis-escape-variant-associated-with-occult-hepatitis-b-virus-in-brazil
#10
Ricardo Wagner de Almeida, Francisco Campello do Amaral Mello, Isabelle Vasconcelos Menegoy, Márcia Paschoal do Espírito Santo, Cléber Ferreira Ginuíno, Paulo Sérgio Fonseca de Sousa, Livia Melo Villar, Elisabeth Lampe, Lia Laura Lewis-Ximenez
BACKGROUND: Many studies have identified mutations in the hepatitis B surface antigen (HBsAg) as important factors limiting the ability of commercial serological assays to detect this viral antigen. However, an association between mutations in the HBsAg gene and the occurrence of occult HBV infection (OBI) in patients has not been established. OBJECTIVES: To detect hepatitis B virus (HBV) DNA in patients with anti-HBc as a unique serological marker, a previously published, cost-effective TaqMan-based real-time polymerase chain reaction (PCR) test with minor groove binding probes was adapted for use in this study...
July 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28591236/predictors-of-success-for-mandibular-repositioning-appliance-in-obstructive-sleep-apnea-syndrome
#11
Thays Crosara Abrahão Cunha, Thais de Moura Guimarães, Teresa Cristina Barros Schultz, Fernanda Ribeiro de Almeida, Thulio Marquez Cunha, Paulo Cezar Simamoto, Lia Rita Azeredo Bittencourt
The characteristics of non-obese patients with mild to moderate Obstructive Sleep Apnea Syndrome (OSAS) who will present with a good response to Mandibular Repositioning Appliance (MRA) treatment have not yet been well established in the literature. The aim of this study is to assess whether polysomnographic (PSG), demographic, anthropometric, cephalometric, and otorhinolaryngological parameters predict MRA success in the treatment of OSAS. Forty (40) males with mild and moderate OSAS were assessed pretreatment and 2-months post-treatment after wearing an MRA...
June 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28575919/zika-virus-infection-in-pregnant-women-and-microcephaly
#12
Geraldo Duarte, Antonio Fernandes Moron, Artur Timerman, César Eduardo Fernandes, Corintio Mariani Neto, Gutemberg Leão de Almeida Filho, Heron Werner Junior, Hilka Flavia Barra do Espírito Santo, João Alfredo Piffero Steibel, João Bortoletti Filho, Juvenal Barreto Borriello de Andrade, Marcelo Burlá, Marcos Felipe Silva de Sá, Newton Eduardo Busso, Paulo César Giraldo, Renato Augusto Moreira de Sá, Renato Passini Junior, Rosiane Mattar, Rossana Pulcineli Vieira Francisco
From the discovery of the Zika virus (ZIKV) in 1947 in Uganda (Africa), until its arrival in South America, it was not known that it would affect human reproductive life so severely. Today, damage to the central nervous system is known to be multiple, and microcephaly is considered the tip of the iceberg. Microcephaly actually represents the epilogue of this infection's devastating process on the central nervous system of embryos and fetuses. As a result of central nervous system aggression by the ZIKV, this infection brings the possibility of arthrogryposis, dysphagia, deafness and visual impairment...
May 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28573190/randomized-trial-of-machine-perfusion-versus-cold-storage-in-recipients-of-deceased-donor-kidney-transplants-with-high-incidence-of-delayed-graft-function
#13
Helio Tedesco-Silva, Juliano Chrystian Mello Offerni, Vanessa Ayres Carneiro, Mayara Ivani de Paula, Elias David Neto, Francine Brambate Carvalhinho Lemos, Lúcio Roberto Requião Moura, Alvaro Pacheco E Silva Filho, Mirian de Fátima de Morais Cunha, Erica Francisco da Silva, Luiz Antonio Miorin, Daniela Priscila Demetrio, Paulo Sérgio Luconi, Waldere Tania da Silva Luconi, Savina Adriana Bobbio, Liz Milstein Kuschnaroff, Irene Lourdes Noronha, Sibele Lessa Braga, Renata Cristina Barsante, João Cezar Mendes Moreira, Ida Maria Maximina Fernandes-Charpiot, Mario Abbud-Filho, Luis Gustavo Modelli de Andrade, Paula Dalsoglio Garcia, Luciana Tanajura Santamaria Saber, Alan Fernandes Laurindo, Pedro Renato Chocair, Américo Lourenço Cuvello Neto, Juliana Aparecida Zanocco, Antonio Jose Duboc de Almeida Soares Filho, Wilson Ferreira Aguiar, Jose Medina Pestana
BACKGROUND: This study compared the use of static cold storage versus continuous hypothermic machine perfusion in a cohort of kidney transplant recipients at high risk for delayed graft function (DGF). METHODS: In this national, multicenter, and controlled trial, 80 pairs of kidneys recovered from brain-dead deceased donors were randomized to cold storage or machine perfusion, transplanted, and followed up for 12 months. The primary endpoint was the incidence of DGF...
May 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28571975/synthesis-spectroscopic-characterization-and-biological-evaluation-of-unsymmetrical-aminosquarylium-cyanine-dyes
#14
Sofia Friães, Amélia M Silva, Renato E Boto, Diana Ferreira, José R Fernandes, Eliana B Souto, Paulo Almeida, Luis F Vieira Ferreira, Lucinda V Reis
New unsymmetrical aminosquarylium cyanine dyes were synthesized and their potential as photosensitizers evaluated. New dyes, derived from benzothiazole and quinoline, were prepared by nucleophilic substitution of the corresponding O-methylated, the key intermediate that was obtained by methylation with CF3SO3CH3 of the related zwitterionic unsymmetrical dye, with ammonia and methylamine, respectively. All three news dyes herein described displayed intense and narrow bands in the Vis/NIR region (693-714nm) and their singlet oxygen formation quantum yields ranged from 0...
May 11, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28569448/outcomes-of-immediate-function-implant-prosthetic-restorations-with-mechanical-complications-a-retrospective-clinical-study-with-5-years-of-follow-up
#15
Paulo Maló, Miguel Alexandre de Araujo Nobre, Carlos Moura Guedes, Ricardo Almeida
Mechanical complications may have a significant impact on the outcome of implant-supported restorations; however, few studies address the topic. This study investigated the outcomes of implant supported restorations with mechanical complications. A total of 378 patients with 378 restorations supported by 1283 implants were included. Results demonstrated a prosthetic and implant cumulative survival rate at 5 years of 99.7% and 95.7%, respectively. Maxillary implants were a determinant for implant failure (hazard ratio= 6...
March 2017: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/28567685/genotoxicity-in-adult-residents-in-mineral-coal-region-a-cross-sectional-study
#16
Edlaine Acosta Da Silva Pinto, Edariane Menestrino Garcia, Krissia Aparecida de Almeida, Caroline Feijó Lopes Fernandes, Ronan Adler Tavella, Maria Cristina Flores Soares, Paulo Roberto Martins Baisch, Ana Luíza Muccillo-Baisch, Flavio Manoel Rodrigues da Silva Júnior
The present study assessed the DNA damage in environmentally exposed volunteers living in seven municipalities in an industrial coal region, through the use of the comet assay with blood cells and the micronucleus test with buccal cells. Blood and buccal smears were collected from 320 male volunteers living in seven cities inserted in a coal region. They were ages of 18 and 50 years and also completed a questionnaire intended to identify factors associated with DNA damage through a Poisson regression analysis...
June 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28562817/continuing-education-in-health-from-the-perspective-of-augustine-of-hippo
#17
Fabíola Chaves Fernandes, Elaine Antunes Cortez, Daniel Laprovita, Lidiane Peixoto de Almeida, Aline Figueiredo Ferreira, Marcos Paulo Fonseca Corvino
Objective: To reflect about continuing education from the perspective of Augustine of Hippo and his theories based on the construction of knowledge and the learning process. Method: This is a theoretical reflection study whose aim is to propose dimensions of analysis, emphasizing the history and challenges of continuing education. Such dimensions analyze the production of knowledge in Augustinian pedagogy, its historical aspects and its close relationship with lifelong education in health professions...
May 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28555506/capability-of-cbct-to-identify-patients-with-low-bone-mineral-density-a-systematic-review
#18
Eliete Neves Silva Guerra, Fabiana Tolentino Almeida, Fernanda Vieira Bezerra, Paulo Tadeu de Souza Figueiredo, Maria Alves Garcia Silva, Graziela De Luca Canto, Camila Pachêco-Pereira, André Ferreira Leite
OBJECTIVE: The aim of this study was to systematically review the literature about the capability of CBCT images to identify individuals with low Bone Mineral Density (BMD). As the literature is scarce regarding this topic, the purpose of this systematic review is also to guide future research in this area. METHODS: A detailed search was performed in five databases without restrictions of time or languages. Additionally, a gray literature search was conducted. QUADAS-2 was applied to evaluate the methodological design of selected studies...
May 30, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28554806/blockade-of-atp-p2x7-receptor-enhances-ischiatic-nerve-regeneration-in-mice-following-a-crush-injury
#19
Tatianne Ribeiro, Júlia Teixeira Oliveira, Fernanda Martins Almeida, Marcelo Amorim Tomaz, Paulo A Melo, Suelen Adriani Marques, Geanne Matos de Andrade, Ana Maria Blanco Martinez
Preventing damage caused by nerve degeneration is a great challenge. There is a growing body of evidence implicating extracellular nucleotides and their P2 receptors in many pathophysiological mechanisms. In this work we aimed to investigate the effects of the administration of Brilliant Blue G (BBG) and Pyridoxalphosphate-6-azophenyl-2', 4'- disulphonic acid (PPADS), P2X7 and P2 non-selective receptor antagonists, respectively, on sciatic nerve regeneration. Four groups of mice that underwent nerve crush lesion were used: two control groups treated with vehicle (saline), a group treated with BBG and a group treated with PPADS during 28 days...
May 26, 2017: Brain Research
https://www.readbyqxmd.com/read/28554002/retrospective-analysis-of-hepatitis-b-virus-chronic-infection-in-247-patients-clinical-stages-response-to-treatment-and-poor-prognostic-factors
#20
Marlone Cunha-Silva, Fábio R T Marinho, Paulo F Oliveira, Tirzah M Lopes, Tiago Sevá-Pereira, Sonia L S Lorena, Jazon R S Almeida
BACKGROUND: Chronic hepatitis B is a major cause of cirrhosis, and the natural history of the disease has several clinical stages that should be thoroughly understood for the implementation of proper treatment. Nonetheless, curing the disease with antiviral treatment remains a challenge. AIMS: To describe the clinical course, response to treatment, and poor prognostic factors in 247 hepatitis B virus chronic infection patients treated in a tertiary hospital in Brazil...
May 26, 2017: Brazilian Journal of Infectious Diseases
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