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Paulo Almeida

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https://www.readbyqxmd.com/read/28191024/recent-trends-in-pharmacological-activity-of-alkaloids-in-animal-colitis-potential-use-for-inflammatory-bowel-disease
#1
REVIEW
Ana Cristina Alves de Almeida, Felipe Meira de-Faria, Ricardo José Dunder, Luis Paulo Bognoni Manzo, Alba Regina Monteiro Souza-Brito, Anderson Luiz-Ferreira
Inflammatory bowel disease (IBD) is a chronic and disrupted inflammation of the gastrointestinal tract. IBD have two main conditions, Crohn's disease and ulcerative colitis, and have been extensively investigated in recent years. Antibiotics derived from salicylates, steroids, immunosuppressors, and anti-TNF therapy are part of the therapeutic arsenal for IBD. However, very often patients stop responding to treatments over the time. In this context, searching for alternative agents is crucial for IBD clinical management...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28189083/structure-based-design-synthesis-and-antitumoral-evaluation-of-enulosides
#2
Jonh A M Santos, Cosme S Santos, Claudia L A Almeida, Thiago D S Silva, João R Freitas Filho, Gardenia C G Militão, Teresinha G da Silva, Carlos H B da Cruz, Juliano C R Freitas, Paulo H Menezes
Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested tumor cells lines, being the best results observed for HL-60 cells. These compounds open new possibilities to prepare an array of more active, site-specific or selective antitumor agents. 2016 Elsevier Ltd. All rights reserved.
January 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28188835/automated-pulse-discrimination-of-two-freely-swimming-weakly-electric-fish-and-analysis-of-their-electrical-behavior-during-a-dominance-contest
#3
Rafael T Guariento, Thiago S Mosqueiro, Paulo Matias, Vinicius B Cesarino, Lirio O B Almeida, Jan F W Slaets, Leonardo P Maia, Reynaldo D Pinto
Electric fishes modulate their electric organ discharges with a remarkable variability. Some patterns can be easily identified, such as pulse rate changes, offs and chirps, which are often associated with important behavioral contexts, including aggression, hiding and mating. However, these behaviors are only observed when at least two fish are freely interacting. Although their electrical pulses can be easily recorded by non-invasive techniques, discriminating the emitter of each pulse is challenging when physically similar fish are allowed to freely move and interact...
February 7, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28185126/zika-virus-and-neuroscience-the-need-for-a-translational-collaboration
#4
Lavínia Schuler-Faccini, Paulo Roehe, Eduardo R Zimmer, André Quincozes-Santos, Adriano M de Assis, Elizabeth Obino Cirne Lima, Jorge Almeida Guimarães, Cesar Victora, Vivaldo Moura Neto, Diogo O Souza
Zika virus (ZIKV) has become a major challenge for scientists and health agencies. ZIKV's involvement with human fetal microcephaly and Guillain-Barré syndrome and its transmission through Aedes africanus and Aedes aegypti mosquitos highlighted the epidemiological and neurological risks associated to ZIKV infection. In 2013, ZIKV arrives in Brazil but the first outbreak in the country was reported in 2015. Here, we used the Web of Science as a search tool for comparing the evolution of world and Brazilian scientific research on dengue virus (DENV)-also present in mosquito-, ZIKV and microcephaly...
February 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28182237/chromosomal-evolution-and-cytotaxonomy-in-wrasses-perciformes-labridae
#5
Leandro A H Almeida, Lorena A Nunes, Jamille A Bitencourt, Wagner F Molina, Paulo R A M Affonso
No abstract text is available yet for this article.
February 9, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28178632/impact-of-bioaccessibility-and-bioavailability-of-phenolic-compounds-in-biological-systems-upon-the-antioxidant-activity-of-the-ethanolic-extract-of-triplaris-gardneriana-seeds
#6
José Joaquim Lopes Neto, Thiago Silva de Almeida, Jackeline Lima de Medeiros, Leonardo Rogério Vieira, Thaís Borges Moreira, Ana Isabel Vitorino Maia, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Davi Felipe Farias, Ana Fontenele Urano Carvalho
The most studied bioactive potential of phenolic compounds corresponds to antioxidant activity, which in turn, is associated with a reduction in the incidence of various human diseases. However, the total quantity of these bioactive substances in foods and medicinal preparations does not reflect the amount absorbed and metabolized by the body. The present study aimed to investigate the bioaccessibility of Triplaris gardneriana seeds ethanolic extract (EETg) by determination of phenolic composition and antioxidant activities before and after in vitro digestion as well as to estimate its bioavailability by chemical analysis of plasma and urine in animal models after oral administration...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28165916/acute-and-late-bartonella-henselae-murine-model-infection
#7
Marilene Neves da Silva, Gislaine Vieira-Damiani, Marna Elise Ericson, Kalpna Gupta, Amanda Roberta de Almeida, Marina Rovani Drummond, Tania Cristina Benetti Soares, Bruno Grosselli Lania, Rovilson Gilioli, Paulo Eduardo Neves Ferreira Velho
Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Cats and dogs are reservoirs of some species of these agents. Blood-sucking arthropods are potential vectors. Our aim was to evaluate the blood, skin, liver, and spleen in BALB/c mice by using molecular tests and confocal microscopy to demonstrate Bartonella henselae infection in the bloodstream and organs after 4 and 21 days of intraperitoneally injected bacterial suspension...
February 6, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28157423/effect-of-nd-yag-and-co2-laser-irradiation-on-prevention-of-enamel-demineralization-in-orthodontics-in-vitro-study
#8
Renato Siva Paulos, Priscila Yumi Seino, Karen Akemi Fukushima, Marcia Martins Marques, Fernanda Campos Sousa de Almeida, Karen Muller Ramalho, Patricia Moreira de Freitas, Aldo Brugnera, Maria Stella Moreira
OBJECTIVE: The aim of this study was to investigate Nd:YAG and CO2 laser effects in the prevention of demineralization in deeper layers of enamel via successive acid challenge cycles. BACKGROUND DATA: Lasers are promising in the prevention of enamel demineralization around the orthodontic brackets; however, there are very few studies that evaluate if the effects of treatment could be extended after successive acid challenge cycles due to permanent enamel structural alterations...
January 18, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28146175/-the-impact-of-the-type-of-hospital-and-delivery-on-the-gestational-age-in-s%C3%A3-o-paulo-city-2013-2014
#9
Priscila Ribeiro Raspantini, Marina Jorge de Miranda, Zilda Pereira da Silva, Gizelton Pereira Alencar, Simone Grilo Diniz, Marcia Furquim de Almeida
Introduction: There was a left-shift on the distribution curve of gestational age (GA) and a reduction of the proportion of live births of 40 weeks, when compared to the expected standard in many countries. Objective: To study the distribution of gestational age births in São Paulo city (SP) and its relationship with the type of hospital and delivery. Methods: Data were extracted from Live Birth Information System (SINASC) linked to the National Database of Health Establishments (CNES) in 2013 and 2014...
October 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28146165/quality-and-completeness-improvement-of-the-population-based-cancer-registry-of-s%C3%A3-o-paulo-linkage-technique-use
#10
Stela Verzinhasse Peres, Maria do Rosário Dias de Oliveira Latorre, Luana Fiengo Tanaka, Fernanda Alessandra Silva Michels, Monica La Porte Teixeira, Claudia Medina Coeli, Márcia Furquim de Almeida
Objective: The aim of this study was to improve the quality of information and data completeness through probabilistic and deterministic record linkage between Population-based Cancer Registry of São Paulo (PBCR-SP) for incident cancer cases, death database and drugs/medical procedures database. Methods: We used the database of the PBCRP-SP composed of 343,306 incident cancer cases in the municipality of São Paulo in the period between 1997 and 2005 with ages raging from under 1 to 106 years old, from both sexes...
October 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28146095/synthesis%C3%A2-of%C3%A2-16%C3%A2-new%C3%A2-hybrids%C3%A2-from%C3%A2-tetrahydropyrans-derivatives%C3%A2-and%C3%A2-morita-baylis-hillman%C3%A2-adducts-%C3%A2-in-vitro%C3%A2-screening%C3%A2-against%C3%A2-leishmania%C3%A2-donovani
#11
Suervy Canuto de Oliveira Sousa, Juliana da Câmara Rocha, Tatjana de Souza Lima Keesen, Everton da Paz Silva, Priscilla Anne Castro de Assis, João Paulo Gomes de Oliveira, Saulo Luís Capim, Francisco José Seixas Xavier, Bruno Guimarães Marinho, Fábio Pedrosa Lins Silva, Claudio Gabriel Lima-Junior, Mário Luiz Araújo de Almeida Vasconcellos
Leishmaniases are a group of neglected tropical diseases (NTDs) caused by protozoan parasites from >20 Leishmania species. Visceral leishmaniasis (VL), also known as kala-aza, is the most severe form of leishmaniasis, usually fatal in the absence of treatment in 95% of cases. The Morita-Baylis-Hillman adducts (MBHAs) are being explored as drug candidates against several diseases, one of them being leishmaniasis. We present here the design, synthesis and in vitro screening against Leishmania donovani of sixteen new molecular hybrids from analgesic/antiinflammatory tetrahydropyrans derivatives and Morita-Baylis-Hillman adducts...
January 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28143725/methylation-at-3-lcr-of-hpv16-can-be-affected-by-patient-age-and-disruption-of-e1-or-e2-genes
#12
Sérgio Menezes Amaro Filho, Neilane Bertoni, Ayslan Castro Brant, João Paulo Castello Branco Vidal, Shayany Pinto Felix, Silvia Maria Baeta Cavalcanti, Fernanda N Carestiato, Luís Felipe Leite Martins, Liz Maria de Almeida, Miguel Angelo Martins Moreira
CpG methylation at early promoter of HPV16 DNA, in the 3' end of the Long Control Region (3'LCR), has been associated to the presence of episomal forms of viral genome and, consequently, intact E1 and E2 ORFs. The DNA methylation would block the access of E2 viral protein to the E2 binding sites at early-promoter. However, is still unclear if methylation at 3'LCR of HPV16 DNA can also vary depending of other tumor characteristics in addition to viral DNA physical state. In this study, we evaluate whether the methylation level at the five CpG located at 3'LCR of HPV16 is associated to patient age and E1 and/or E2 ORFs integrity...
January 29, 2017: Virus Research
https://www.readbyqxmd.com/read/28137428/statistical-process-control-of-cocrystallization-processes-a-comparison-between-opls-and-pls
#13
Ana F T Silva, Mafalda Cruz Sarraguça, Paulo R Ribeiro, Adenilson O Santos, Thomas De Beer, João Almeida Lopes
Orthogonal partial least squares regression (OPLS) is being increasingly adopted as an alternative to partial least squares (PLS) regression due to the better generalization that can be achieved. Particularly in multivariate batch statistical process control (BSPC), the use of OPLS for estimating nominal trajectories is advantageous. In OPLS, the nominal process trajectories are expected to be captured in a single predictive principal component while uncorrelated variations are filtered out to orthogonal principal components...
January 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28128776/musculoskeletal-disorders-and-stress-among-footwear-industry-workers
#14
Larissa Brentini de Almeida, Edgar Ramos Vieira, José Eduardo Zaia, Branca Maria de Oliveira Santos, Américo Riccardi Vaccari Lourenço, Paulo Roberto Veiga Quemelo
BACKGROUND: Manufacturing footwear requires intense manual labor and high repetitions with low variability in function that may lead to musculoskeletal disorders (MSD) symptoms and psychological stress. OBJECTIVE: to evaluate a potential association between musculoskeletal disorders (MSD) and perceived stress among footwear industry workers. METHODS: The Nordic General Questionnaire (NGQ) and the Perceived Stress Scale (PSS-10) were completed by 357 footwear industry workers...
January 23, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28125119/-aedes-aegypti-and-aedes-albopictus-in-bromeliads-grown-in-the-bauru-municipal-botanical-gardens-s%C3%A3-o-paulo-brazil
#15
Viviane Camila de Oliveira, Luiz Carlos de Almeida
The aim of this study was to observe the occurrence of mosquito larvae, especially Aedes aegypti and Aedes albopictus, in the tanks and axillae of bromeliads at the Bauru Municipal Botanical Gardens, São Paulo, Brazil, highlighting the epidemiological implications for the use of these plants. The majority of the larvae belonged to mosquitos from genus Culex, with only occasional findings of A. aegypti and A. albopictus. The use of screens for protection of the plants, exposure to sunlight, and larger amounts of water in the tanks may have influenced the occurrence and grouping of larvae...
January 23, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28124812/an-insight-on-salting-out-assisted-liquid-liquid-extraction-for-phytoanalysis
#16
Inês M Valente, Manuela M Moreira, Pâmela Neves, Thiago da Fé, Luís M Gonçalves, Paulo J Almeida, José A Rodrigues
INTRODUCTION: Salting-out assisted liquid-liquid extraction (SALLE) is a technique that, although simple and not requiring any complex equipment, is very powerful and versatile. It has obtained growing interest in bioanalysis particularly when combined with chromatographic techniques. OBJECTIVES: Herein, fennel seeds (Foeniculum vulgare Mill.) were used as a case-study to show the application of SALLE in phytochemical analysis. MATERIAL AND METHODS: SALLE combined with HPLC-UV-MS/MS and GC-MS...
January 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28124405/the-use-of-educational-video-to-promote-maternal-self-efficacy-in-preventing-early-childhood-diarrhoea
#17
Emanuella Silva Joventino, Lorena Barbosa Ximenes, Jardeliny Corrêa da Penha, Lucilande Cordeiro de Oliveira Andrade, Paulo César de Almeida
Diarrhoea is responsible for high rates of infant morbidity and mortality. It is multifactorial, manifested by socioeconomic, hygienic, and maternal factors. The aim of this study is to evaluate the effects of an educational video on maternal self-efficacy for the prevention of childhood diarrhoea. This was a randomised trial conducted in the state of Ceará, Brazil. Participants were 2 groups (comparison and intervention), composed of mothers of children under 5 years of age. Group membership was allocated by cluster randomization...
January 25, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28119029/analysis-of-expression-of-fli1-and-mmp1-in-american-cutaneous-leishmaniasis-caused-by-leishmania-braziliensis-infection
#18
Lucas Almeida, Juliana A Silva, Viviane M Andrade, Paulo Machado, Sarra E Jamieson, Edgar M Carvalho, Jenefer M Blackwell, Léa C Castellucci
FLI1 (Friend leukemia virus integration 1) and IL6 (interleukin 6; IL-6) are associated with Leishmania braziliensis susceptibility. Cutaneous lesions show exaggerated matrix metalloproteinase 1 (MMP1). In other skin diseases, FLI1 promoter methylation reduces FLI1 expression, and low FLI1 down-regulates MMP1. IL-6 increases FLI1 expression. We hypothesized that epigenetic regulation of FLI1 in cutaneous leishmaniasis, together with IL-6, might determine MMP1 expression. While generally low (<10%), percent FLI1 promoter methylation was lower (P=0...
January 21, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28116414/cognitive-training-through-mhealth-for-individuals-with-substance-use-disorder
#19
Pedro Gamito, Jorge Oliveira, Paulo Lopes, Rodrigo Brito, Diogo Morais, Cristina Caçoete, André Leandro, Teresa Almeida, Hugo Oliveira
BACKGROUND: Heroin addiction has a negative impact on cognitive functions, and even recovering addicts suffer from cognitive impairment. Recent approaches to cognitive intervention have been taking advantage of what new technologies have to offer. OBJECTIVES: We report a study testing the efficacy of a serious games approach using tablets to stimulate and rehabilitate cognitive functions in recovering addicts. METHODS: A small-scale cognitive training program with serious games was run with a sample of 14 male heroin addicts undergoing a rehabilitation program...
January 24, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28109535/resistance-training-minimizes-the-biomechanical-effects-of-aging-in-three-different-rat-tendons
#20
Rita de Cássia Marqueti, Jeeser Alves Almeida, Wilson Romero Nakagaki, Vinicius Guzzoni, Fábio Boghi, Adriana Renner, Paulo Eugênio Silva, João Luiz Quagliotti Durigan, Heloisa Sobreiro Selistre-de-Araújo
Aging process is characterized by a decline in the organism functionality, especially in the decrease of muscle function, which also affects tendons. On the other hand, the resistance training (RT) has been used as an important tool to increase muscle and tendineous function during aging. Thus, this study aim has been to verify the effects of RT on the biomechanical properties of three different aged rat tendons. For this purpose, 20 wistar rats have been divided into four groups (5 rats per group): young sedentary (YS), trained (YT), old sedentary (OS) and old trained (OT)...
December 29, 2016: Journal of Biomechanics
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