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nutritional treatment diabetes

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https://www.readbyqxmd.com/read/29208058/low-protein-diet-supplemented-with-ketoacids-delays-the-progression-of-diabetic-nephropathy-by-inhibiting-oxidative-stress-in-the-kkay-mice-model
#1
Dongmei Liu, Ming Wu, Lin Li, Xiang Gao, Bo Yang, Shuqin Mei, Lili Fu, Changlin Mei
Diabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone...
December 6, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29190136/nutritional-insulin-or-glp-1-receptor-agonist-crossroads-in-the-treatment-of-type-2-diabetes-mellitus
#2
Rajesh Garg
No abstract text is available yet for this article.
November 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29184229/effect-of-soaking-and-germination-on-physicochemical-and-functional-attributes-of-horsegram-flour
#3
Vanshika Handa, Vikas Kumar, Anil Panghal, Sheenam Suri, Jaspreet Kaur
Horsegram is an underutilized pulse, traditionally used for treating various disorders like kidney stones, diabetes and joint pain. The present study was undertaken to optimize the soaking and germination conditions, to decrease the anti-nutritional factors and at the same time maintaining the nutritional properties of horsegram. Horsegram seeds were soaked for 6, 12 and 18 h followed by germination for 0, 24 and 48 h under different illumination conditions i.e., light and dark respectively. The soaked and germinated samples were dried in laboratory drier at 55 °C until constant moisture was achieved and was further analyzed for various quality attributes...
December 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29181767/frailty-diabetes-and-the-convergence-of-chronic-disease-in-an-age-related-condition-a-population-based-nationwide-cross-sectional-analysis-of-the-mexican-nutrition-and-health-survey
#4
Roberto C Castrejón-Pérez, Carlos A Aguilar-Salinas, Luis M Gutiérrez-Robledo, Matteo Cesari, Mario U Pérez-Zepeda
AIMS: To describe the associations of frailty with diabetes mellitus and related conditions in older adults. METHODS: We conducted a cross-sectional analysis of a representative sample of older adults (n = 5379). We generated a 35-item frailty index (FI) and obtained information on diabetes and related conditions (peripheral neuropathy, lower limb amputation, diabetic coma, number of physician visits due to diabetes-related conditions, all-cause hospitalizations in the past year, years since diabetes diagnosis, and type of treatment)...
November 27, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29181437/clinical-features-of-patients-treated-by-peritoneal-dialysis-for-over-a-decade
#5
Mengli Tong, Yuhui Wang, Jun Ni, Ning Weng, Chuanxia Chen, Hongyu Chen, Lindholm Bengt
BACKGROUND: Peritoneal dialysis (PD) is well-established as renal replacement therapy in end stage renal disease and has survival rates similar or better than hemodialysis (HD) for the initial years on dialysis therapy. However retention rate is lower due to higher technique failure rates than in HD and few patients stay on PD for more than 10 years (PD>10 yrs). Here we investigated clinical features characterizing PD>10 yrs patients. PATIENTS AND METHODS: In a single center study of 450 prevalent PD patients, 35 PD>10 yrs patients (n=35) were compared with patients (n=415) who had been on PD for shorter periods of time in terms of clinical characteristics...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29170059/the-clinical-potential-of-adipogenesis-and-obesity-related-micrornas
#6
REVIEW
M Zaiou, H El Amri, A Bakillah
Obesity is a growing health problem commonly associated with numerous metabolic disorders including type 2 diabetes, hypertension, cardiovascular disease, and some forms of cancer. The burden of obesity and associated cardiometabolic diseases are believed to arise through complex interplay between genetics and epigenetics predisposition, nutrition, environment, and lifestyle. However, the molecular basis and the repertoire of obesity-affecting factors are still unknown. Emerging evidence is connecting microRNAs (miRNAs) dysregulation with adipogenesis and obesity...
November 20, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29166886/trends-in-cardiovascular-risk-factors-among-u-s-men-and-women-with-and-without-diabetes-1988-2014
#7
Xingxing Sun, Tingting Du
BACKGROUND: Studies evidenced that reduction in cardiovascular disease (CVD) mortality in diabetic patients can be attributed to improvements in major CVD risk factors and evidence-based treatments. Furthermore, studies showed that the relative risk of CVD mortality associated with diabetes compared with non-diabetes is stronger in women than in men. Hence, we aimed to examine trends in CVD risk factors and intervention measures by sex and diabetic status. METHODS: Analysis of 5 distinct cross-sectional National Health and Nutrition Examination Surveys, 1988-1994, 1999-2002, 2003-2006, 2007-2010, and 2010-2014...
November 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29164177/a-systems-medicine-approach-translating-emerging-science-into-individualized-wellness
#8
REVIEW
J S Bland, D M Minich, B M Eck
In today's aging society, more people are living with lifestyle-related noncommunicable diseases (NCDs) such as cardiovascular disease, type 2 diabetes, obesity, and cancer. Numerous opinion-leader organizations recommend lifestyle medicine as the first-line approach in NCD prevention and treatment. However, there is a strong need for a personalized approach as "one-size-fits-all" public health recommendations have been insufficient in addressing the interindividual differences in the diverse populations. Advancement in systems biology and the "omics" technologies has allowed comprehensive analysis of how complex biological systems are impacted upon external perturbations (e...
2017: Advances in Medicine
https://www.readbyqxmd.com/read/29162514/increased-sugar-intake-as-a-form-of-compensatory-hyperphagia-in-patients-with-type-2-diabetes-under-dapagliflozin-treatment
#9
Ichiro Horie, Norio Abiru, Ryoko Hongo, Takeshi Nakamura, Ayako Ito, Ai Haraguchi, Shoko Natsuda, Ikuko Sagara, Takao Ando, Atsushi Kawakami
AIMS: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) cause substantially less weight loss than would be expected based on their caloric deficits, probably due to enhanced appetite regulation known as "compensatory hyperphagia," which occurs to offset the negative energy balance caused by increased glycosuria. We examined whether any specific nutrients contributed to the compensatory hyperphagia in diabetic patients taking SGLT2i. METHODS: Sixteen patients with type 2 diabetes were newly administered dapagliflozin 5 mg daily as the experimental SGLT2i group...
November 18, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29162216/treatment-regimens-by-pediatric-nephrologists-in-children-with-congenital-nephrogenic-diabetes-insipidus-a-mwpnc-study%C3%A2
#10
Cynthia D'Alessandri-Silva, Melinda Carpenter, John D Mahan
BACKGROUND: Congenital nephrogenic diabetes insipidus (NDI) is a rare genetic disorder affecting urinary concentration. Clinicians have varied medication regimens as well as nutritional plan approaches for these children. MATERIALS AND METHODS: An electronic survey was distributed to member pediatric nephrologists of the Midwest Pediatric Nephrology Consortium via email (n = 179). Questions included types of drugs prescribed, factors contributing to drug choice, common drug combinations given, and dietary/failure to thrive interventions used...
November 22, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29151717/bariatric-surgery-a-perspective-for-primary-care
#11
Scott Kizy, Cyrus Jahansouz, Keith Wirth, Sayeed Ikramuddin, Daniel Leslie
IN BRIEF Bariatric surgery is the most efficacious treatment for obesity, type 2 diabetes, and other obesity-related comorbidities. In this article, the authors review the current indications for bariatric surgery and discuss the most commonly performed procedures. They analyze medical outcomes of bariatric procedures by reviewing key prospective trials and discuss changes in physiology after these procedures. They conclude by discussing long-term management of bariatric patients by reviewing current guidelines for nutritional support and listing common complications related to these procedures...
November 2017: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29145757/nutrition-and-lower-extremity-ulcers-causality-and-or-treatment
#12
Lauren Haughey, Adrian Barbul
The association between malnutrition, impaired wound healing, and the presence of chronic wounds has been recognized for a long time. It is widely believed that the lack of adequate nutrition increases the risk of developing wounds which have a great likelihood of progressing to chronicity due to lack of appropriate healing responses. This risk is particularly high in the aging population. For the individual patient, as well as patient populations, the diagnosis of malnutrition has been in dispute; further, there is lack of agreement of when and how to intervene nutritionally in those with wounds or healing deficits...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29143888/-the-art-of-insulin-treatment-diabetes-insulin-and-the-1920s
#13
Kirsten E Gardner
Soon after the discovery of insulin in the early 1920s, the popular press celebrated the miraculous discovery. Although insulin had no curative effect on the chronic state of diabetes, it was frequently heralded as a "cure." This paper examines how the discovery of insulin intersected with the rise of diabetic technology and the transfer of medical technology to the home setting. By analyzing diabetic manuals written for patients and physicians, letters exchanged between patient and physician, medical journals, magazines and newspapers, I trace how patients learned about insulin and more significantly how patients adopted measurement technologies designed to allow better home administration of insulin...
November 16, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/29136189/serum-omega-3-fatty-acids-and-treatment-outcomes-among-women-undergoing-assisted-reproduction
#14
Y-H Chiu, A E Karmon, A J Gaskins, M Arvizu, P L Williams, I Souter, B R Rueda, R Hause, J E Chavarro
STUDY QUESTION: Are serum polyunsaturated fatty acids (PUFA) concentrations, including omega-3 (ω3-PUFA) and omega-6 (ω6-PUFA), related to ART outcomes? SUMMARY ANSWER: Serum levels of long-chain ω3-PUFA were positively associated with probability of live birth among women undergoing ART. WHAT IS KNOWN ALREADY: Intake of ω3-PUFA improves oocyte and embryo quality in animal and human studies. However, a recent cohort study found no relation between circulating ω3-PUFA levels and pregnancy rates after ART...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29130725/-eighth-jes%C3%A3%C2%BAs-culebras-lecture-critical-care-nutrition-and-hyperglycemia-a-close-relationship
#15
Alfonso Mesejo
Critically ill patients show a metabolic response to injury that affects carbohydrate metabolism, causing hyperglycemia and an increase in glycemic variability that makes the critically ill patient susceptible to infection, resulting in morbidity and mortality increase. Also, severe hypoglycemia was detected as a consequence of intensive insulin treatment that provokes deleterious effects in their clinical evolution, so a correct monitoring of plasma glucose would contribute to reduce morbidity and mortality...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29130231/-effect-of-postoperative-hyperglycemia-on-clinical-outcome-of-gastrointestinal-fistula-patients-undergoing-gastrointestinal-reconstruction
#16
Qiongyuan Hu, Jian'an Ren, Wenhao Tang, Jieshou Li
OBJECTIVE: To investigate the effect of hyperglycemia within postoperative 48 hours on gastrointestinal (GI) fistula patients without preoperative diagnosis of diabetes undergoing selective GI reconstruction. METHODS: Clinical data of GI fistula patients with age of 18 to 70 years and without diffuse peritonitis and systemic infection undergoing definitive GI reconstruction at Intestinal Fistula Center of Jinling Hospital from September 2012 to December 2015 were retrospectively analyzed...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29129996/addressing-hypertension-in-the-patient-with-type-2-diabetes-mellitus-pathogenesis-goals-and-therapeutic-approach
#17
Ali A Rizvi
Hypertension is considered a powerful cardiovascular risk factor and is present in up to two-thirds of patients who suffer from diabetes. In the background of an established epidemiological association between lower blood pressure (BP) and improvement in long-term clinical outcomes, several large landmark trials and analyses have attempted to examine the possible benefit of tighter BP control in patients with Type 2 diabetes mellitus. Although aggressive BP targets in patients with diabetes have been advocated for a long time, currently accepted evidence from these studies has led to a general recommendation of systolic BP <140 mmHg and diastolic BP <90 mmHg...
October 2017: European Medical Journal. Diabetes
https://www.readbyqxmd.com/read/29121676/naringin-prevents-hiv-1-protease-inhibitors-induced-metabolic-complications-in-vivo
#18
Sanelisiwe Nzuza, Sindiswa Zondi, Peter M O Owira
BACKGROUND: Insulin resistance, glucose intolerance and overt diabetes are known metabolic complications associated with chronic use of HIV-Protease Inhibitors. Naringin is a grapefruit-derived flavonoid with anti-diabetic, anti-dyslipidemia, anti-inflammatory and anti-oxidant activities. OBJECTIVES: The study investigated the protective effects of naringin on glucose intolerance and impaired insulin secretion and signaling in vivo. METHODS: Male Wistar rats were divided into six groups (n = 6) and were daily orally treated with distilled water {3...
2017: PloS One
https://www.readbyqxmd.com/read/29113111/the-mxl-3-sbp-1-axis-is-responsible-for-glucose-dependent-fat-accumulation-in-c-elegans
#19
Fanny Mejia-Martinez, Berenice Franco-Juarez, Elizabeth Moreno-Arriola, Alain Hernández-Vázquez, Marco Martinez-Avila, Saul Gómez-Manzo, Jaime Marcial-Quino, Karla Carvajal, Antonio Velazquez-Arellano, Daniel Ortega-Cuellar
Chronic exposure to elevated glucose levels leads to fatty acid accumulation, which promotes the development of metabolic diseases such as obesity and type 2 diabetes. MXL-3 is a conserved transcriptional factor that modulates the inhibition of lipolysis in Caenorhabditis elegans. However, the role of MXL-3 in lipid metabolism during nutrient excess remains unknown. We hypothesized that inhibition of MXL-3 prevents glucose-dependent fat accumulation. Nematodes from wild-type N2, MXL-3::GFP and sbp-1 or mxl-3 null strains were grown on standard, high glucose or high glucose plus metformin plates for 24 h...
November 6, 2017: Genes
https://www.readbyqxmd.com/read/29110244/the-effect-of-6-and-12%C3%A2-months-duodenal-jejunal-bypass-liner-treatment-on-obesity-and-type-2-diabetes-a-crossover-cohort-study
#20
Selwyn van Rijn, Bark Betzel, Charlotte de Jonge, David P J van Dijk, Ignace M Janssen, Frits J Berends, Nicole D Bouvy, Jan Willem M Greve
OBJECTIVE: The aim of this research was to study the duodenal-jejunal bypass liner (DJBL) treatment for obesity and type 2 diabetes mellitus (T2DM) in patients after dietary treatment in a cross-over design. BACKGROUND: DJBL treatment has been proven effective for treatment of obesity and T2DM. However, data on safety and efficacy of a 12-month DJBL treatment is limited. METHODS: In 2014, our research group reported on a multicenter randomized clinical trial...
November 6, 2017: Obesity Surgery
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