keyword
MENU ▼
Read by QxMD icon Read
search

diclofenac

keyword
https://www.readbyqxmd.com/read/29777833/endocrine-disrupting-activities-and-immunomodulatory-effects-in-lymphoblastoid-cell-lines-of-diclofenac-4-hydroxydiclofenac-and-paracetamol
#1
Ivana Klopčič, Tijana Markovič, Irena Mlinarič-Raščan, Marija Sollner Dolenc
A critical literature review reveals that knowledge of side effects of pharmaceuticals diclofenac and paracetamol is extremely important because of their widespread use and occurrence in the environment. In order to delineate whether these compounds have endocrine activity and influence on the immune system, we assessed the potential endocrine disrupting and immunomodulatory activities of: diclofenac (DIC), its metabolite 4-hydroxydiclofenac (4-HD) and paracetamol (PAR). Herein, we report on their impact on estrogen receptor (ER), androgen receptor (AR), glucocorticoid receptor (GR) and thyroid hormone receptor (TR)...
May 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29772283/amphiphilic-polyurethane-hydrogels-as-smart-carriers-for-acidic-hydrophobic-drugs
#2
Lucas P Fonseca, Rafael B Trinca, Maria Isabel Felisberti
Amphiphilic hydrogels are widely reported as systems with great potential for controlled drug release. Nevertheless, the majority of studies make use of functionalization or attachment of drugs to the polymer chains. In this study, we propose a strategy of combining amphiphilic polyurethanes with pH-responsive drugs to develop smart drug carriers. While the amphiphilic character of the polymer imparts an efficient load of hydrophobic and hydrophilic drugs, the drug's characteristics determine the selectivity of the medium delivery...
May 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29771681/selective-adsorption-of-oppositely-charged-pnipaam-on-halloysite-surfaces-a-route-to-thermo-responsive-nanocarriers
#3
Giuseppe Cavallaro, Giuseppe Lazzara, Lorenzo Lisuzzo, Stefana Milioto, Filippo Parisi
Halloysite nanotubes were functionalized with stimuli-responsive macromolecules to generate smart nanohybrids. Poly(N-isopropylacrylamide)-co-methacrylic acid (PNIPAAM-co-MA) was selectively adsorbed into halloysite lumen by exploiting electrostatic interactions. Amine-terminated PNIPAAM polymer was also investigated that selectively interacts with the outer surface of the nanotubes. The adsorption site has a profound effect on the thermodynamic behavior and therefore temperature responsive features of the hybrid material...
May 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29767520/enhanced-oxidative-and-adsorptive-removal-of-diclofenac-in-heterogeneous-fenton-like-reaction-with-sulfide-modified-nanoscale-zerovalent-iron
#4
Yiming Su, David Jassby, Shikun Song, Xuefei Zhou, Hongying Zhao, Jan Filip, Eleni Petala, Yalei Zhang
Sulfidation of nanoscale zerovalent iron (nZVI) has shown some fundamental improvements on reactivity and selectivity towards pollutants in dissolved oxygen (DO) stimulated Fenton-like reaction systems (DO/S-nZVI system). However, the pristine micro-structure of sulfide modified nanoscale zerovalent iron (S-nZVI) remains uncovered. In addition, the relationship between pollutant removal and the oxidation of the S-nZVI is largely unknown. The present study confirms that sulfidation not only imparts sulfide and sulfate groups onto the surface of the nanoparticle (both on the oxide shell and on flake-like structures), but also introduces sulfur into the Fe(0) core region...
May 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29766827/pain-related-behavior-and-brain-activation-in-a-cynomolgus-macaque-model-of-postoperative-pain
#5
Aldric Hama, Takahiro Natsume, Shin'ya Ogawa, Yūji Awaga, Ikuo Hayashi, Akihisa Matsuda, Hiroyuki Takamatsu
BACKGROUND: Inadequate postoperative pain management could lead to persistent pain and this is, in part, due to incomplete understanding of the mechanism of postoperative pain. Currently available rodent models may have limited translatability to clinical postoperative pain. Thus, a preclinical model of postoperative pain was developed in the cynomolgus macaque, a species that is phylogenetically closer to humans than rodents. METHOD: The presence of pressure hypersensitivity was assessed with non-noxious pressure applied proximally and distally (approximately 10 cm) to an abdominal incision in macaques...
May 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29766729/cardiovascular-risk-of-non-steroidal-anti-inflammatory-drugs
#6
Štefan Alušík, Zoltán Paluch
Non-steroidal anti-inflammatory drugs (NSAIDs) belong to the most widely used drugs. Results of recent large meta-analyses have shown that the cardiovascular risk of NSAIDs is more serious than originally believed and is not associated exclusively with coxibs; it is also increased when using so called traditional NSAIDs. Data obtained to date show the safest drugs of this class in terms of cardiovascular risk are naproxen and ibuprofen at low doses. The position of naproxen as the safest NSAID has been challenged by some more recent findings...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29766368/systemic-contact-dermatitis
#7
REVIEW
Marcella Aquino, Greg Rosner
Systemic contact dermatitis (SCD) traditionally refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross reacting allergen via a different route. It occurs to allergens including metals, medications, and foods. The exact pathophysiology underlying this disease remains unknown, although it appears to be mediated by type 4 hypersensitivity reactions and possibly type 3 hypersensitivity reactions. The p-I concept (pharmacologic interaction with immunoreceptors) hypothesized that drugs are able to bind directly to a T cell receptor without first being presented by MHC (major histocompatibility complex) molecules and without prior metabolism, which would help explain why SCD can be seen on first exposure to medications...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29763781/inhibition-of-vegf-gene-expression-in-osteoblast-cells-by-different-nsaids
#8
Francisco Javier Manzano-Moreno, Victor Javier Costela-Ruiz, Lucía Melguizo-Rodríguez, Rebeca Illescas-Montes, Olga García-Martínez, Concepción Ruiz, Javier Ramos-Torrecillas
OBJECTIVE: To determine the effect of different nonsteroidal anti-inflammatory drugs (NSAIDs) on vascular endothelial growth factor (VEGF) gene expression in two osteoblast cell populations. DESIGN: Osteoblasts obtained by primary culture (HOp) and human osteosarcoma cell line MG63 (MG-63), which were treated with 10 μM doses of acetaminophen, indomethacin, ketoprofen, diclofenac, ibuprofen, ketorolac, naproxen or piroxicam. At 24 h of treatment, their gene expression of VEGF was evaluated by real-time polymerase chain reaction (RT-PCR) and compared with the expression in untreated cells (control group)...
May 9, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29759253/development-of-electrochemically-controlled-packed-in-tube-solid-phase-microextraction-method-for-sensitive-analysis-of-acidic-drugs-in-biological-samples
#9
Hamid Asiabi, Yadollah Yamini, Maryam Shamsayei
In the present research, for the first time, a novel "packed-in-tube" configuration has been applied to electrochemically controlled in-tube solid phase microextraction, followed by high performance liquid chromatography. In order to prepare a mini packed column, small beads of stainless steel were first placed into the stainless steel column. Then, a nanostructured polypyrrole film was prepared on the internal surface of a stainless steel tube and the surface of stainless steel particles through a facile in-situ electrodeposition method...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759249/in-line-carbon-nanofiber-reinforced-hollow-fiber-mediated-liquid-phase-microextraction-using-a-3d-printed-extraction-platform-as-a-front-end-to-liquid-chromatography-for-automatic-sample-preparation-and-analysis-a-proof-of-concept-study
#10
Chanatda Worawit, David J Cocovi-Solberg, Pakorn Varanusupakul, Manuel Miró
A novel concept for automation of nanostructured hollow-fiber supported microextraction, combining the principles of liquid-phase microextraction (LPME) and sorbent microextraction synergically, using mesofluidic platforms is proposed herein for the first time, and demonstrated with the determination of acidic drugs (namely, ketoprofen, ibuprofen, diclofenac and naproxen) in urine as a proof-of-concept applicability. Dispersed carbon nanofibers (CNF) are immobilized in the pores of a single-stranded polypropylene hollow fiber (CNF@HF) membrane, which is thereafter accommodated in a stereolithographic 3D-printed extraction chamber without glued components for ease of assembly...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759061/role-of-ultrasound-guided-transversus-abdominis-plane-block-as-a-component-of-multimodal-analgesic-regimen-for-lower-segment-caesarean-section-a-randomized-double-blind-clinical-study
#11
Ashok Jadon, Priyanka Jain, Swastika Chakraborty, Mayur Motaka, Sudhansu Sekhar Parida, Neelam Sinha, Amit Agrawal, Asit Kumar Pati
BACKGROUND: While opioids are the mainstay for post-operative analgesia after lower segment caesarean section, they are associated with various untoward effects. Ultrasound guided transversus abdominis plane (TAP) block has been postulated to provide effective analgesia for caesarean section. We evaluated the analgesic efficacy of this block for post caesarean analgesia in a randomised controlled trial. METHODS: One hundred thirty-nine mothers undergoing caesarean delivery were randomised to receive TAP block with either 20 ml 0...
May 14, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29758221/inhibition-of-striatal-cholinergic-interneuron-activity-by-the-kv7-opener-retigabine-and-the-nonsteroidal-anti-inflammatory-drug-diclofenac
#12
Rodrigo Manuel Paz, Cecilia Tubert, Agostina Stahl, Analía López Díaz, Roberto Etchenique, Mario Gustavo Murer, Lorena Rela
Striatal cholinergic interneurons provide modulation to striatal circuits involved in voluntary motor control and goal-directed behaviors through their autonomous tonic discharge and their firing "pause" responses to novel and rewarding environmental events. Striatal cholinergic interneuron hyperactivity was linked to the motor deficits associated with Parkinson's disease and the adverse effects of chronic antiparkinsonian therapy like l-DOPA-induced dyskinesia. Here we addressed whether Kv7 channels, which provide negative feedback to excitation in other neuron types, are involved in the control of striatal cholinergic interneuron tonic activity and response to excitatory inputs...
May 11, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29753231/vascular-brain-derived-neurotrophic-factor-pathway-in-rats-with-adjuvant-induced-arthritis-effect-of-anti-rheumatic-drugs
#13
Martin Pedard, Aurore Quirié, Perle Totoson, Frank Verhoeven, Philippe Garnier, Anne Tessier, Céline Demougeot, Christine Marie
BACKGROUND AND AIMS: In rheumatoid arthritis, the control of both disease activity and standard cardiovascular (CV) risk factors is expected to attenuate the increased CV risk. Evidence that brain-derived neurotrophic factor (BDNF) plays a role in vascular biology led us to investigate the vascular BDNF pathway in arthritis rats as well as the interaction between endothelial nitric oxide (NO) and BDNF production. METHODS: The aortic BDNF pathway was studied in rats with adjuvant-induced arthritis, (AIA) using Western blot and immunohistochemical analysis...
May 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29749723/high-controlled-diffusion-drug-release-from-ureasil-poly-ethylene-oxide-na-montmorillonite-hybrid-hydrogel-nanocomposites
#14
Celso Ricardo Jesus, Eduardo Ferreira Molina, Sandra Helena Pulcinelli, Celso V Santilli
In this work, we report the effects of incorporation of variable amounts (1-20 wt%) of sodium montmorillonite (MMT) into a siloxane-poly(ethylene oxide) hybrid hydrogel prepared by the sol-gel route. The aim was to control the nanostructural features of the nanocomposite, improve the release profile of the drug sodium diclofenac (SDCF), and optimize the swelling behavior of the hydrophilic matrix. The nanoscopic characteristics of the siloxane-crosslinked poly(ethylene oxide) network, the semi-crystallinity of the hybrid, and the intercalated or exfoliated structure of the clay were investigated by X-ray diffraction (XRD), small-angle X-ray scattering (SAXS), and differential scattering calorimetry (DSC)...
May 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29746127/discovery-of-novel-nonsteroidal-anti-inflammatory-drugs-and-carbonic-anhydrase-inhibitors-hybrids-nsaids-cais-for-the-management-of-rheumatoid-arthritis
#15
Ozlem Akgul, Lorenzo Di Cesare Mannelli, Daniela Vullo, Andrea Angeli, Carla Ghelardini, Gianluca Bartolucci, Abdulmalik Saleh Alfawaz Altamimi, Andrea Scozzafava, Claudiu T Supuran, Fabrizio Carta
Herein we report the design as well as the synthesis of a new series of dual hybrid compounds consisting of the therapeutically used Nonsteroidal-Anti-Inflammatory Drugs (NSAIDs ;i.e. indometacin, sulindac, ketoprofen, ibuprofen, diclofenac, ketorolac, etc., cyclooxygenase inhibitors) and the Carbonic Anhydrase Inhibitor (CAIs) fragments of the sulfonamide type. Such compounds are proposed as new tools for the management of ache symptoms associated to rheumatoid arthritis (RA) and related inflammation diseases...
May 10, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29744776/determination-of-nine-pharmaceutical-active-compounds-in-surface-waters-from-paraopeba-river-basin-in-brazil-by-ltpe-hplc-esi-ms-ms
#16
André Luis Correa de Barros, Felix Florian Schmidt, Sérgio Francisco de Aquino, Robson José de Cássia Franco Afonso
A simple, inexpensive, versatile, and environment-friendly extraction method, using low-temperature partitioning extraction (LTPE), was validated to quantify pharmaceutical-active compounds (PhACs) in surface water samples by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). The PhACs analyzed were acetaminophen, bezafibrate, diclofenac, diltiazem, fluconazole, linezolid, miconazole, ondansetron hydrochloride, and trimethoprim. The detection and quantification limits ranged from 0...
May 9, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29736386/evaluation-of-antinociceptive-antihyperglycemic-and-membrane-stabilizing-activities-of-garcinia-lancifolia-roxb
#17
Antara Ghosh, Sujan Banik, Mohammad Nurul Amin, Jamiuddin Ahmed
This study was undertaken to examine the antinociceptive, antihyperglycemic, and membrane stabilizing activity with phytochemical screening of methanolic extract of Garcinia lanceifolia whole plant. The extracts were subjected to in-vivo antinociceptive, antihyperglycemic activity in laboratory animals and in-vitro membrane stabilizing activity. In peripheral antinociceptive activity, G. lanceifolia (400 and 200 mg/kg) exhibited significant (P < 0.001) inhibition of writhing with 59.15% and 49.30% respectively comparable to standard Diclofenac (54...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29735869/effects-of-a-cyclic-nsaid-regimen-on-levels-of-gingival-crevicular-fluid-prostaglandin-e-2-and-interleukin-1%C3%AE-a-6-month-randomized-controlled-clinical-trial
#18
B F Oduncuoglu, N A Kayar, S Haliloglu, B Serpek, T Ataoglu, N O Alptekin
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while the adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic administration of NSAIDs may reduce or eliminate these effects. We evaluated the effect of a cyclic diclofenac potassium (DP) regimen on clinical parameters and levels of prostaglandin E2 (PGE2 ) and interleukin-1β (IL-1β) in the gingival crevicular fluid (GCF) of individuals with periodontitis...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29733797/comparison-of-safety-and-efficacy-of-silodosin-solifenacin-tadalafil-and-their-combinations-in-the-treatment-of-double-j-stent-related-lower-urinary-system-symptoms-a-prospective-randomized-trial
#19
Rohit Bhattar, Vinay Tomar, Sher Singh Yadav, Devendra Singh Dhakad
OBJECTIVE: To evaluate the efficacy and safety of silodosin, solifenacin, tadalafil and their combinations in reducing double J (DJ) stent-related symptoms (SRS). MATERIAL AND METHODS: A total of 335 patients who underwent DJ stenting and develop SRS at 1st week were randomized into eight groups. Ureteral stent symptom questionnaire (USSQ) and Quality of life (QOL) scores were noted in each group: Group A-Silodosin (8 mg OD)+ Solifenacin (10 mg OD)+ Tadalafil (5 mg OD), B - Silodosin 8 mg OD, C - Solifenacin 10 mg OD, D- Tadalafil 5 mg OD, E- Silodosin (8 mg OD) + Solifenacin (10 mg OD), F- Silodosin (8 mg 0D)+ Tadalafil (5 mg OD), G- Solifenacin (10 mg OD)+ Tadalafil (5 mg OD) and H-placebo...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29732583/analgesic-and-anti-inflammatory-activities-of-epicatechin-gallate-from-bauhinia-hookeri
#20
Eman Al-Sayed, Mohamed M Abdel-Daim
Hit, Lead & Candidate Discovery The acetic acid-induced writhing and hot plate models in mice were utilized to determine the analgesic effect of epicatechin gallate (ECG) isolated from Bauhinia hookeri. The anti-inflammatory activity of ECG was determined using carrageenan-induced paw edema model. The pro-inflammatory mediators (PGE2 , TNF-α, IL-1β, and IL-6) were estimated in the plasma of different treatment groups. ECG was tested at doses of 100, 200, and 400 mg/kg p.o. and diclofenac sodium was used as a standard drug (100 mg/kg) in all experiments...
May 6, 2018: Drug Development Research
keyword
keyword
40882
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"