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https://www.readbyqxmd.com/read/27929234/low-dose-morphine-less-effective-than-diclofenac-or-acetaminophen-for-renal-colic
#1
Henry C Barry
No abstract text is available yet for this article.
October 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27928713/corticosteroid-transdermal-delivery-significantly-improves-arthritis-pain-and-functional-disability
#2
Tommaso Iannitti, Michael F McDermott, Carmen Laurino, Andrea Malagoli, Beniamino Palmieri
Arthritis is characterized by pain and functional limitation affecting the patients' quality of life. We performed a clinical study to investigate the efficacy of a betamethasone valerate medicated plaster (Betesil) in improving pain and functional disability in patients with arthritis and osteoarthritis. We enrolled 104 patients affected by osteoarthritis (n = 40) or arthritis (n = 64) in different joints. Patients received diclofenac sodium cream (2 g, four times a day) or a 2.25-mg dose of Betesil applied to the painful joint every night before bedtime for 10 days...
December 7, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27927089/an-evaluation-of-the-anti-inflammatory-antipyretic-and-analgesic-effects-of-hydroethanol-leaf-extract-of-albizia-zygia-in-animal-models
#3
Wonder Kofi Mensah Abotsi, Stanley Benjamin Lamptey, Stephen Afrane, Eric Boakye-Gyasi, Ruth Uwa Umoh, Eric Woode
CONTEXT: The leaves of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) are used in Ghanaian traditional medicine for the treatment of pain, inflammatory disorders and fever (including malaria). OBJECTIVES: The present study evaluated the anti-inflammatory, antipyretic and analgesic effects of the hydroethanol leaf extract of Albizia zygia (AZE) in animal models. MATERIALS AND METHODS: The anti-inflammatory and antipyretic effects of AZE were examined in the carrageenan-induced foot oedema model and the baker's yeast-induced pyrexia test respectively...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27925272/analysis-of-community-level-mesocosm-data-based-on-ecologically-meaningful-dissimilarity-measures-and-data-transformation
#4
Cleo Tebby, Sandrine Joachim, Paul J Van den Brink, Jean-Marc Porcher, Rémy Beaudouin
The Principal Response Curve (PRC) method is a constrained ordination method developed specifically for the analysis of community data collected in mesocosm experiments which provides easily understood summaries and graphical representations of community response to stress. PRC is a redundancy analysis (RDA) method and is usually performed on log-transformed abundance data. The choice of a measure of dissimilarity between samples and the choice of the data transformation significantly affect the results of multivariate analysis...
December 7, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27923161/antinociceptive-tolerance-to-nsaids-in-the-rat-formalin-test-is-mediated-by-the-opioid-mechanism
#5
Nana Tsiklauri, Ivliane Nozadze, Gulnaz Gurtskaia, Merab G Tsagareli
BACKGROUND: In the past decade it has been shown that tolerance develops to the antinociceptive effect of repeated systemic administration of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) in acute pain models using rats. This is similar to the tolerance observed with opioid-induced analgesia. In the present study, we investigated the development of tolerance to the analgesic effects of NSAIDs diclofenac, ketorolac and xefocam in a chronic inflammatory pain model, the formalin test...
October 6, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27922549/unreported-side-effect-of-intravitreal-diclofenac-in-chronic-diabetic-macular-edema
#6
Lavanya Chidambara, Rekha Singhal, Priya Srinivasan, Naresh Kumar Yadav
PURPOSE: To evaluate the safety and efficacy of intravitreal diclofenac sodium. METHODS: A 61-year-old male with persistent diabetic macular edema was treated with 450 μg of intravitreal diclofenac sodium (systemic preparation). RESULTS: Postinjection Day 1, the spectral domain optical coherence tomography showed irregular vitreoretinal interface with wrinkling and separation of the internal limiting membrane from the nerve fiber layer with homogeneity of the inner layers...
December 2, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27919541/pesticides-drive-risk-of-micropollutants-in-wastewater-impacted-streams-during-low-flow-conditions
#7
Nicole A Munz, Francis J Burdon, Dick de Zwart, Marion Junghans, Laura Melo, Marta Reyes, Urs Schönenberger, Heinz P Singer, Barbara Spycher, Juliane Hollender, Christian Stamm
Micropollutants enter surface waters through various pathways, of which wastewater treatment plants (WWTPs) are a major source. The large diversity of micropollutants and their many modes of toxic action pose a challenge for assessing environmental risks. In this study, we investigated the potential impact of WWTPs on receiving ecosystems by describing concentration patterns of micropollutants, predicting acute risks for aquatic organisms and validating these results with macroinvertebrate biomonitoring data...
November 3, 2016: Water Research
https://www.readbyqxmd.com/read/27918295/a-new-antibacterial-silver-i-complex-incorporating-2-5-dimethylpyrazine-and-the-anti-inflammatory-diclofenac
#8
Sevim Hamamci Alisir, Necmi Dege
Ag(I)-containing coordination complexes have attracted attention because of their photoluminescence properties and antimicrobial activities and, in principle, these properties depend on the nature of the structural topologies. A novel two-dimensional silver(I) complex with the anti-inflammatory diclofenac molecule, namely bis{μ-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ(3)O,O':O}bis(μ-2,5-dimethylpyrazine-κ(2)N:N')silver(I), [Ag2(C14H10Cl2NO2)2(C6H8N2)]n, (I), has been synthesized and characterized by single-crystal X-ray diffraction, revealing that the Ag(I) ions are chelated by the carboxylate groups of the anionic 2-[2-(2,6-dichloroanilino)phenyl]acetate (dicl) ligand in a μ3-η(1):η(2) coordination mode...
December 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/27916242/the-effect-of-pregabalin-and-methylcobalamin-combination-on-the-chronic-postthoracotomy-pain-syndrome
#9
Serda Kanbur Metin, Burhan Meydan, Serdar Evman, Talha Dogruyol, Volkan Baysungur
BACKGROUND: Chronic postthoracotomy pain (CPTP) consists of different types of pain. Some characteristics of CPTP are the same as those of recognized neuropathic pain syndromes. We aimed to determine the safety and efficacy of pregabalin and methylcobalamin combination (PG-B12) in comparison with diclofenac potassium (DP) in patients with CPTP. METHODS: One hundred consecutive patients with CPTP after posterolateral/lateral thoracotomy were prospectively randomly assigned and evaluated...
December 1, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27915141/a-review-of-the-occurrence-of-pharmaceuticals-and-personal-care-products-in-indian-water-bodies
#10
REVIEW
Keshava Balakrishna, Amlan Rath, Yerabham Praveenkumarreddy, Keerthi Siri Guruge, Bikram Subedi
Little information exists on the occurrence and the ultimate fate of pharmaceuticals in the water bodies in India despite being one of the world leaders in pharmaceutical production and consumption. This paper has reviewed 19 published reports of pharmaceutical occurrence in the aquatic environment in India [conventional activated sludge wastewater treatment plants (WTPs), hospital WTPs, rivers, and groundwater]. Carbamazepine (antipsychoactive), atenolol (antihypertensive), triclocarban and triclosan (antimicrobials), trimethoprim and sulfamethoxazole (antibacterials), ibuprofen and acetaminophen (analgesics), and caffeine (stimulant) are the most commonly detected at higher concentrations in Indian WTPs that treat predominantly the domestic sewage...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27913026/assessing-membrane-fouling-and-the-performance-of-pilot-scale-membrane-bioreactor-mbr-to-treat-real-municipal-wastewater-during-winter-season-in-nordic-regions
#11
Khum Gurung, Mohamed Chaker Ncibi, Mika Sillanpää
In this study, the performance of a pilot-scale membrane bioreactor (MBR) to treat real municipal wastewater was assessed at low temperatures (7 to 20°C) in Nordic regions. First, the effect of low temperatures on membrane fouling was evaluated by monitoring trans-membrane pressure. A significant membrane fouling was observed when the sludge temperature inside the MBR unit was below 10°C with a 75% permeability drop, thus indicating high deterioration of the membrane performance at low temperatures. Moreover, increasing values of sludge volume index (SVI) during low temperatures showed high deterioration of sludge settleability...
November 29, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27912131/preparation-of-a-magnetic-n-fe-ac-catalyst-for-aqueous-pharmaceutical-treatment-in-heterogeneous-sonication-system
#12
Nan Zhang, He Zhao, Guangming Zhang, Shan Chong, Yucan Liu, Liyan Sun, Huazhen Chang, Ting Huang
High efficiency and facile separation are desirable for catalysts used in water treatment. In this study, a magnetic catalyst (nitrogen doped iron/activated carbon) was prepared and used for pharmaceutical wastewater treatment. The catalyst was characterized using BET, SEM, XRD, VSM and XPS. Results showed that iron and nitrogen were successfully loaded and doped, magnetic Fe2N was formed, large amount of active surface oxygen and Fe(II) were detected, and the catalyst could be easily separated from water. Diclofenac was then degraded using the catalyst in ultrasound system...
November 29, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27910782/chemoprevention-of-colon-cancer-through-inhibition-of-angiogenesis-and-induction-of-apoptosis-by-nonsteroidal-anti-inflammatory-drugs
#13
Preety Ghanghas, Shelly Jain, Chandan Rana, Sankar Nath Sanyal
Cancer cells require nourishment for the growth of the primary tumor mass and spread of the metastatic colony. These needs are fulfilled by tumor-associated neovasculature known as angiogenesis, which also favors the transition from hyperplasia to neoplasia, that is, from a state of cellular multiplication to uncontrolled proliferation. Therefore, targeting angiogenesis is profitable as a mechanism to inhibit tumor growth. Furthermore, it is important to understand the cross-communication between vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in the neoplastic and proinflammatory milieu...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27909962/efficiency-of-osmotic-concentration-after-combined-treatment-with-vasopressin-and-blockage-of-prostaglandin-synthesis
#14
V A Lavrinenko, A V Babina
We performed a complex functional study of the effects of prostaglandin synthesis blockage with diclofenac on manifestation of the hydroosmotic effect of vasopressin V2-receptor agonist desmopressin in the kidneys of Wistar rats with normal synthesis of endogenous vasopressin and homozygous Brattleboro rats with hereditary impaired synthesis of neurohypophyseal hormone vasopressin. Blockage of prostaglandin synthesis led to more pronounced increase in urine osmolality in Brattleboro rats than in Wistar rats due to elevation of not only urine but also sodium gradient at the expense of elimination of the inhibitory effect of prostaglandins on sodium reabsorption and membrane permeability for urine...
December 2, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27906936/analgesic-effect-of-nalbuphine-when-added-to-intravenous-regional-anesthesia-a-randomized-control-trial
#15
Mohamed Hassan Bakri, Eman Ahmed Ismail, Sayed Kaoud Abd-Elshafy
BACKGROUND: Different adjuvant drugs are currently added to lidocaine for intravenous regional anesthesia (IVRA) to decrease tourniquet and postoperative pain. OBJECTIVE: The aim of the study was to examine the effect of nalbuphine when added toIVRA. STUDY DESIGN: Prospective, randomized, double-blind, controlled clinical trial. SETTING: Assiut University Hospitals. METHODS: One hundred-six adult patients scheduled for unilateral hand surgery under IVRA were randomized into 2 equal groups...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27896256/comparative-analysis-of-outcome-between-laparoscopic-versus-open-surgical-repair-for-vesico-vaginal-fistula
#16
Bastab Ghosh, Varun Wats, Dilip Kumar Pal
OBJECTIVE: Vesicovaginal fistula (VVF) causes detrimental psychosomatic effects on a woman. It is repaired using open abdominal as well as laparoscopic approach. Here we compare a series of open versus laparoscopic VVF repairs done at a single centre. METHODS: Retrospectively data of patients undergoing VVF repair in our department between January 2011 to December 2014 was analyzed. Patients who had a single, primary, simple VVF following a gynaecological surgery were included in the study...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27892726/design-and-characterization-of-neurodurable-gellan-xanthan-ph-responsive-hydrogels-for-controlled-drug-delivery
#17
Poornima Ramburrun, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Viness Pillay
OBJECTIVES: The purpose of this study was to develop novel, porous neurodurable interpenetrating networks of gellan-xanthan hydrogel conduits intercalated with pristine polymethyl methacrylate (PMMA) particles for the sustained and concurrent release of two model compounds: bovine serum albumin (BSA) and diclofenac sodium. METHODS: Hydrogel conduits were synthesized using a thermal-ionic crosslinking mechanism with direct incorporation of PMMA. The 15 formulations, generated using a Box-Behnken experimental design, were analyzed for drug release, swelling, erosion and textural properties...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27891455/unmasking-the-effect-of-analgesics-on-endodontic-diagnosis-using-a-novel-bite-force-sensor-device-a-prospective-randomized-clinical-trial
#18
Sushil Kishnani, Suparna Ganguly Saha, Anuj Bhardwaj, Sandeep Dubey, Mainak Saha, Shubham Kala, Sohini Jain, Shweta Narwani
INTRODUCTION: A definitive diagnosis is of primary importance before initiating any endodontic treatment; yet, there are occasions when the dental professional is unable to accurately reproduce the patient's chief complaint, as it can pose a dilemma and may require consideration of multiple variables in order to reach an accurate diagnosis. So to overcome this problem, a methodical approach in providing endodontic treatment should be implemented which includes diagnosis, definitive dental treatment and adjunctive drug therapy, known as the "3D" strategy...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891231/a-pharmacokinetic-evaluation-and-metabolite-identification-of-the-ghb-receptor-antagonist-ncs-382-in-mouse-informs-novel-therapeutic-strategies-for-the-treatment-of-ghb-intoxication
#19
Garrett R Ainslie, K Michael Gibson, Kara R Vogel
Gamma-aminobutyric acid (GABA) is an endogenous inhibitory neurotransmitter and precursor of gamma-hydroxybutyric acid (GHB). NCS-382 (6,7,8,9-tetrahydro-5-hydroxy-5H-benzo-cyclohept-6-ylideneacetic acid), a known GHB receptor antagonist, has shown significant efficacy in a murine model of succinic semialdehyde dehydrogenase deficiency (SSADHD), a heritable neurological disorder featuring chronic elevation of GHB that blocks the final step of GABA degradation. NCS-382 exposures and elimination pathways remain unknown; therefore, the goal of the present work was to obtain in vivo pharmacokinetic data in a murine model and to identify the NCS-382 metabolites formed by mouse and human...
December 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/27887033/skin-irritation-and-sensitization-potential-of-fixed-dose-combination-of-diclofenac-1-and-menthol-3-topical-gel-results-of-two-phase-i-patch-studies
#20
D Jeffery Liu, A Collaku, J S Dosik
Phase I, randomized, controlled patch studies were conducted to evaluate skin sensitization and irritation potential of a new gel formulation containing 1% diclofenac and 3% menthol as a fixed-combination product.In study A, healthy volunteers were exposed to 4 test patches containing 1% diclofenac+3% menthol, diclofenac, menthol, or placebo gels during an induction (nine 48 to 72-h applications) and challenge phase (one 48-h application). Some subjects were re-challenged to evaluate suspected sensitization...
November 25, 2016: Drug Research
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