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https://www.readbyqxmd.com/read/28222304/fabrication-of-novel-visible-light-driven-agi-g-c3n4-composites-with-enhanced-visible-light-photocatalytic-activity-for-diclofenac-degradation
#1
Wei Zhang, Li Zhou, Jun Shi, Huiping Deng
A visible-light-driven heterostructured AgI/g-C3N4 was prepared by a deposition-precipitation method. The composition, structure, morphology, and optical properties of the photocatalyst were characterized by Brunauer-Emmett-Teller method (BET), X-ray powder diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), transmission electron microscope (TEM), scanning electron microscope (SEM), UV-vis diffused reflectance spectroscopy (DRS), photoluminescence spectroscopy (PL), photocurrent, and electrochemical impedance spectroscopy (EIS), respectively...
February 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28220730/the-prevalence-of-skin-scars-in-patients-previously-given-intramuscular-diclofenac-injections-attending-the-pain-clinic-at-universitas-academic-hospital-bloemfontein-south-africa
#2
D Tarloff, G Lamacraft, G Joubert
Intramuscular (IM) diclofenac rarely causes scarring (reported incidence <0.05%). Some patients attending the Pain Clinic at Universitas Academic Hospital, Bloemfontein, South Africa, presented with scars that had developed after IM diclofenac injections. We investigated the prevalence of scars in patients at the clinic and how the injections had been obtained. Patients attending the clinic over a period of 9 months who said they had received diclofenac (N=131) were included. Information was collected using a questionnaire and physical examination...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28214398/effects-of-recirculation-in-a-three-tank-pilot-scale-system-for-pharmaceutical-removal-with-powdered-activated-carbon
#3
Victor Kårelid, Gen Larsson, Berndt Björlenius
The removal of pharmaceutically active compounds by powdered activated carbon (PAC) in municipal wastewater is a promising solution to the problem of polluted recipient waters. Today, an efficient design strategy is however lacking with regard to high-level overall, and specific, substance removal in the large scale. The performance of PAC-based removal of pharmaceuticals was studied in pilot-scale with respect to the critical parameters; contact time and PAC dose using one PAC product selected by screening in bench-scale...
February 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28202281/photodegradation-of-diclofenac-in-seawater-by-simulated-sunlight-irradiation-the-comprehensive-effect-of-nitrate-fe-iii-and-chloride
#4
N Zhang, J M Li, G G Liu, X L Chen, K Jiang
Diclofenac is one of the most frequently detected pharmaceuticals in various aquatic environments. The photodegradation of diclofenac in the absence/presence of nitrate, Fe(III) and chloride, especially their interactions, were systematically studied. Under the study conditions, photodegradation rate was decreased with increasing nitrate, Fe(III) and chloride concentrations. Nitrate has an synergistic action for Fe(III). Nitrate and chloride have antagonistic effect. An antagonistic action is present between nitrate, Fe(III) and chloride...
February 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28199939/sorption-and-desorption-of-selected-non-steroidal-anti-inflammatory-drugs-in-an-agricultural-loam-textured-soil
#5
Y Zhang, G W Price, R Jamieson, D Burton, K Khosravi
Non-steroidal, anti-inflammatory drugs (NSAIDs) are widely used pharmaceutical products with analgesic and anti-inflammatory effects that are consistently detected in municipal wastewater systems and in municipal biosolids. Land application of biosolids and irrigation with reclaimed wastewater introduces these compounds into agricultural environments, which is an emerging issue of concern for ecosystem health. In this study, the sorption-desorption behaviour of four commonly consumed NSAIDs, including naproxen (NPX), ibuprofen (IBU), ketoprofen (KTF), and diclofenac (DCF), was examined in a loam textured soil exposed to either an individual-compound or a mixture of the four NSAIDs...
February 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28199788/development-of-fluorescence-surrogates-to-predict-the-photochemical-transformation-of-pharmaceuticals-in-wastewater-effluents
#6
Shuwen Yan, Bo Yao, Lushi Lian, Xinchen Lu, Shane A Snyder, Rui Li, Weihua Song
The photochemical transformation of pharmaceutical and personal care products (PPCPs) in wastewater effluents is an emerging concern for environmental scientists. In the current study, the photodegradation of 29 PPCPs was examined in effluents under simulated solar irradiation. Direct photodegradation, triplet state effluent organic matter (3EfOM*)-mediated and hydroxyl radical (HO•)-mediated degradation are three major pathways in the removal process. With the photodegradation of trace levels of PPCPs, the excitation-emission matrix (EEM) fluorescence intensities of the effluents were also gradually reduced...
February 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28198617/cometabolic-enzymatic-transformation-of-organic-micropollutants-under-methanogenic-conditions
#7
Lorena Gonzalez-Gil, Marta Carballa, Juan M Lema
Anaerobic digestion (AD) has been shown to have the biological potential to decrease the concentrations of several organic micropollutants (OMPs) from sewage sludge. However, the mechanisms and factors behind these biotransformations, which are essential for elucidating the possible transformation products and to foster the complete removal of OMPs via operational strategies, remain unclear. Therefore, this study investigated the transformation mechanisms of 20 OMPs during the methanogenic step of AD with a focus on the role of acetate kinase (AK), which is a key enzyme in methane production...
February 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28197809/determination-of-diclofenac-and-n-acetylcysteine-by-an-optimized-luminescence-method-using-cds-quantum-dots-as-sensitizers
#8
Abdolraouf Samadi-Maybodi, Ali Tilehkan, Mohammad-Rasool Sadeghi-Maleki
A simple, sensitive and selective chemiluminescence method is proposed for the determination of Acetylcysteine and Diclofenac in pharmaceutical samples. The method is based on the measuring light intensity of NaHCO3-H2O2 @ CdS chemiluminescence system in the absence and presence of Acetylcysteine and Diclofenac. It was found that the intensity of chemiluminescence is increased by addition of acetylcysteine while the light intensity is decreased with increasing diclofenac concentration. The CdS quantum dots nanoparticles were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), UV-Vis spectrophotometry and Fluorescence spectroscopy...
February 14, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28197031/efficacy-of-preprocedural-diclofenac-in-men-undergoing-double-j-stent-removal-under-local-anesthesia-a-double-blind-randomized-control-trial
#9
Vilvapathy Senguttuvan Karthikeyan, Ramaiah Keshavamurthy, Ashwin Mallya, Manohar Chikka Moga Siddaiah, Sumit Kumar, Chulai Rajabahadhur Chandrashekar
INTRODUCTION: Double J (DJ) stents are often removed under local anesthesia using a rigid cystoscope. Patients experience significant pain during this procedure and also continue to have discomfort during voiding for a few days. We assessed the efficacy and safety of preemptive oral diclofenac in pain relief in patients undergoing DJ stent removal (DJSR) by rigid cystoscopy compared to placebo. METHODS: Consecutive consenting male patients undergoing DJSR under local anesthesia between March 2014 and July 2015 were enrolled...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28194525/low-dose-solumatrix-diclofenac-in-patients-with-osteoarthritis-pain-impact-on-quality-of-life-in-a-controlled-trial
#10
Vibeke Strand, Martin Bergman, Jasvinder A Singh, Allan Gibofsky, Alan Kivitz, Clarence Young
Low-dose SoluMatrix diclofenac was developed to provide effective pain relief for osteoarthritis pain. We evaluated the effects of SoluMatrix diclofenac on health-related quality of life (HRQoL) measures in patients with osteoarthritis, hypothesizing that SoluMatrix-treated patients would experience significant improvement compared with placebo. In this 12-week, phase 3 randomized controlled trial, 305 patients with osteoarthritis of the hip or knee received SoluMatrix diclofenac 35 mg three times (TID) or twice (BID) daily or placebo...
February 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28190750/role-of-diclofenac-sodium-and-paracetamol-on-colonic-anastomosis-an-experimental-rodent-model
#11
Osman Bilgin Gulcicek, Ali Solmaz, Hakan Yigitbas, Candas Ercetin, Erkan Yavuz, Kamil Ozdogan, Aytac Biricik, Asli Kahraman Akkalp, Hafize Uzun, Muge Kutnu, Fatih Celebi, Atilla Celik
BACKGROUND: Despite many advances in surgery and technology, colonic anastomosis remains a challenge after colonic resection. The purpose of this study is to compare the safety of using diclofenac sodium and paracetamol for analgesia in colonic anastomosis on rats. METHODS: Wistar-Hannover rats were randomly allocated to four groups: Group 1, sham-operated group; Group 2, control group; Group 3, diclofenac sodium group; Group 4, paracetamol group. After laparotomy, the left colon was transected and a single-layer anastomosis was made with 5/0 vicryl in Groups 2, 3, and 4...
February 10, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28189104/generic-method-for-the-absolute-quantification-of-glutathione-s-conjugates-application-to-the-conjugates-of-acetaminophen-clozapine-and-diclofenac
#12
Michiel W den Braver, Nico P E Vermeulen, Jan N M Commandeur
Modification of cellular macromolecules by reactive drug metabolites is considered to play an important role in the initiation of tissue injury by many drugs. Detection and identification of reactive intermediates is often performed by analyzing the conjugates formed after trapping by glutathione (GSH). Although sensitivity of modern mass spectrometrical methods is extremely high, absolute quantification of GSH-conjugates is critically dependent on the availability of authentic references. Although (1)H NMR is currently the method of choice for quantification of metabolites formed biosynthetically, its intrinsically low sensitivity can be a limiting factor in quantification of GSH-conjugates which generally are formed at low levels...
February 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28189026/mass-spectrometry-based-in%C3%A2-vitro-assay-investigations-on-the-transformation-of-pharmaceutical-compounds-by-oxidative-enzymes
#13
Lara F Stadlmair, Thomas Letzel, Jörg E Drewes, Johanna Graßmann
The ubiquitous presence of trace organic chemicals in wastewater and surface water leads to a growing demand for novel removal technologies. The use of isolated enzymes has been shown to possess the capability for a targeted application but requires a clearer mechanistic understanding. In this study, the potential of peroxidase from horseradish (HRP) and laccase from Pleurotus ostreatus (LccPO) to transform selected trace organic chemicals was studied using mass spectrometry (MS)-based in vitro enzyme assays...
February 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28187390/the-fate-of-pharmaceuticals-and-personal-care-products-ppcps-endocrine-disrupting-contaminants-edcs-metabolites-and-illicit-drugs-in-a-wwtw-and-environmental-waters
#14
Edward Archer, Bruce Petrie, Barbara Kasprzyk-Hordern, Gideon M Wolfaardt
A large number of emerging contaminants (ECs) are known to persist in surface waters, and create pressure on wastewater treatment works (WWTW) for their effective removal. Although a large database for the levels of these pollutants in water systems exist globally, there is still a lack in the correlation of the levels of these pollutants with possible long-term adverse health effects in wildlife and humans, such as endocrine disruption. The current study detected a total of 55 ECs in WWTW influent surface water, 41 ECs in effluent, and 40 ECs in environmental waters located upstream and downstream of the plant...
January 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28185988/effects-of-nonsteroidal-anti-inflammatory-drugs-on-the-renal-excretion-of-indoxyl-sulfate-a-nephro-cardiovascular-toxin-in-rats
#15
Chung-Ping Yu, Douglas H Sweet, Yu-Hsuan Peng, Yow-Wen Hsieh, Pei-Dawn Lee Chao, Yu-Chi Hou, Shiuan-Pey Lin
Chronic kidney disease (CKD) is a health problem worldwide. Indoxyl sulfate (IS) is a nephro-cardiovascular toxin accumulated in CKD patients and cannot be removed through hemodialysis. The renal excretion of IS was mediated by organic anion transporters (OATs) OAT 1 and OAT 3. Because a number of nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to inhibit OATs, we hypothesize that NSAIDs might inhibit the renal excretion of IS. Rats were intravenously injected IS with and without diclofenac, ketoprofen or salicylic acid, individually...
February 7, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28179185/the-use-of-diclofenac-sodium-in-urological-practice-a-structural-and-neurochemical-based-review
#16
REVIEW
Mahmut Ulubay, Kıymet Kübra Yurt, Arife Ahsen Kaplan, Mustafa Kemal Atilla
Diclofenac sodium (DS) is a non-steroidal anti-inflammatory drug with antipyretic and analgesic effects. It is mainly found in the form of sodium salt. The mechanism of action of DS operates by way of cyclooxygenase (COX) inhibition. The physiological effect of this substance derives from a decrease in prostaglandin production. DS is a benzeneacetic acid derivative with anti-inflammatory properties. As a non-steroidal anti-inflammatory drug (NSAID), DS binds to both forms of COX (COX-1 and COX-2) and inhibits the conversion of arachidonic acid into pro-inflammatory prostaglandins by means of chelation...
February 5, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28178591/attenuation-of-stress-induced-memory-deficits-by-nonsteroidal-anti-inflammatory-drugs-nsaids-in-rats-role-of-antioxidant-enzymes
#17
Shaista Emad, Sara Qadeer, Sana Sadaf, Zehra Batool, Saida Haider, Tahira Perveen
BACKGROUND: Repeated stress paradigms have been shown to cause devastating alterations on memory functions. Stress is linked with inflammation. Psychological and certain physical stressors could lead to neuroinflammation. Inflammatory process may occur by release of mediators and stimulate the production of prostaglandins through cyclooxygenase (COX). Treatment with COX inhibitors, which restrain prostaglandin production, has enhanced memory in a number of neuroinflammatory states showing a potential function for raised prostaglandins in these memory shortfalls...
November 29, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28178072/side-effects-can-enhance-treatment-response-through-expectancy-effects-an-experimental-analgesic-randomized-controlled-trial
#18
Chantal Berna, Irving Kirsch, Sean R Zion, Yvonne C Lee, Karin B Jensen, Pamela Sadler, Ted J Kaptchuk, Robert R Edwards
In randomized controlled trials (RCTs), medication side effects may lead to beliefs that one is receiving the active intervention and enhance active treatment responses, thereby majoring drug-placebo differences. We tested these hypotheses with an experimental double-blind RCT of a nonsteroidal anti-inflammatory medication (NSAID) with and without the addition of atropine to induce side effects. One hundred healthy volunteers were told they would be randomized to either combined analgesics that might produce dry mouth or inert placebos...
February 4, 2017: Pain
https://www.readbyqxmd.com/read/28177673/interleukin-1beta-suppresses-the-ventilatory-hypoxic-response-in-rats-via-prostaglandin-dependent-pathways
#19
Nina Pavlovna Aleksandrova, Galina Anatol'yevna Danilova, Vjacheslav Georgievich Aleksandrov
We investigated the effect of the major inflammatory cytokine interleukin-1beta (IL-1β) on the ventilatory response to hypoxia. The goal was to test the hypothesis that IL-1β impairs the hypoxic ventilatory response in vivo by indirectly inhibiting respiratory neurons in the brainstem via prostaglandins. Thus, IL-1β was delivered by cerebroventricular injection, and the ventilatory hypoxic response was assessed in anesthetized, spontaneously breathing rats pretreated with or without diclofenac, a nonspecific inhibitor of prostaglandin synthesis...
January 22, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28175958/metabolic-and-co-metabolic-transformation-of-diclofenac-by-enterobacter-hormaechei-d15-isolated-from-activated-sludge
#20
Salima Aissaoui, Houria Ouled-Haddar, Mohamed Sifour, Kamel Harrouche, Haitham Sghaier
The presence of non-steroidal anti-inflammatory drugs, such as diclofenac (DCF), in the environment, is an emerging problem due to their harmful effects on non-target organisms, even at low concentrations. We studied the biodegradation of DCF by the strain D15 of Enterobacter hormaechei. The strain was isolated from an activated sludge, and identified as E. hormaechei based on its physiological characteristics and its 16 S RNA sequence. Using HPTLC and GC-MS methods, we demonstrated that this strain metabolized DCF at an elimination rate of 52...
March 2017: Current Microbiology
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