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https://www.readbyqxmd.com/read/29340711/microbial-degradation-of-triclosan-by-a-novel-strain-of-dyella-sp
#1
Shizong Wang, Yanan Yin, Jianlong Wang
A novel strain capable of degrading triclosan was isolated from the acclimated activated sludge and identified to be Dyella sp. WW1 based on 16S rDNA analysis. The effect of initial concentration of triclosan (0.2, 1, 5, and 10 mg/L), temperature (15, 25, and 35 °C), pH (5, 7, and 9), and additional carbon source on the degradation of triclosan was investigated in a mineral medium. The results showed that Dyella sp. WW1 can use triclosan as sole carbon source and degrade it when initial triclosan concentration was in the range of 0...
January 16, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29338163/kounis-syndrome-induced-by-oral-intake-of-diclofenac-potassium
#2
Harun Gunes, Feruza Turan Sonmez, Ayhan Saritas, Yasin Koksal
An acute coronary syndrome (ACS) occurring during the course of an allergic reaction is called Kounis syndrome (KS). The second case of KS induced by diclofenac potassium (DP) is presented in this report. A 67-year-old man was brought to our emergency department with the possible diagnosis of anaphylactic shock by the ambulance staff. It emerged that widespread erythema and pruritus developed after taking DP. Then, he lost consciousness. Diffuse urticarial lesions were detected on physical examination at the emergency department...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29335758/toxicity-of-diclofenac-in-the-fern-azolla-filiculoides-and-the-lichen-xanthoria-parietina
#3
Andrea Vannini, Luca Paoli, Marco Vichi, Martin Bačkor, Miriam Bačkorová, Stefano Loppi
This study investigated the occurrence of toxicity, expressed as damage to the photosynthetic apparatus, in the aquatic fern Azolla filiculoides and the lichen Xanthoria parietina following treatments with diclofenac at different concentrations (0.1, 1, 10 and 100 mg/L) and different exposure times (24, 48, 72 and 240 h). Measurements of photosynthetic efficiency, chlorophyll content and chlorophyll degradation indicated dose- and time-dependent toxicity, since significant differences with control samples as well as among treatments, emerged mainly for the highest concentration (100 mg/L) and the longest time (240 h)...
January 16, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29332199/analysis-of-the-data-on-pregnancy-and-lactation-provided-by-patient-information-leaflets-of-anti-rheumatic-drugs-in-argentina
#4
Miguel Ormaza Sabando, Maira Arias Saavedra, Gabriel Sequeira, Eduardo Kerzberg
To analyse the level of consistency and updating of the information on pregnancy and lactation provided by patient information leaflets (PILs) of the antirheumatic drugs approved in Argentina. Inconsistencies between the 2016 EULAR Task Force recommendations on the use of anti-rheumatic drugs during pregnancy and lactation and the information provided by PILs of the same drugs approved in Argentina were analysed along with inconsistencies within the PILs of different registered trademarks of these drugs. Eighty-eight PILs of 32 drugs were analysed...
January 13, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29331894/pharmaceutical-concentration-variability-at-sewage-treatment-plant-outlets-dominated-by-hydrology-and-other-factors
#5
Andrea F Brunsch, Thomas L Ter Laak, Huub Rijnaarts, Ekkehard Christoffels
A study was conducted in which the effluent at four small to medium sized sewage treatment plants (STP) in North Rhine-Westphalia, Germany was monitored for three pharmaceutical compounds (carbamazepine, diclofenac, metoprolol) over a period of four years. Grab sampling and auto sampling campaigns were accomplished with respect to various weather conditions in the catchment area. Flow volumes and hydraulic retention times (HRT) from various sampling dates which provide information on processes causing emission changes were additionally taken into account...
January 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29330978/intramuscular-diclofenac-vs-periprostatic-lidocaine-injection-for-controlling-pain-undergoing-transrectal-ultrasound-guided-prostatic-biopsy
#6
Syed Iftikhar Alam, Hazratullah, Zeeshan Kibria, Iqra Masood, Rubab Jawed
BACKGROUND: Transrectal ultrasound (TRUS) technique for getting prostatic tissue for histopathology is now the standard procedure for malignant lesions of the prostate and imperative diagnostic investigation of patients with clinical specks of prostatic neoplasia. During TRUS guided biopsy, pain control has been important issue therefore, highly potent analgesia before this procedure should be considered on high priority according to current census. Therefore, we compared intramuscular diclofenac injection with sensory blockade of injection lidocaine to abolish pain undergoing prostatic biopsy with TRUS technique...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29329011/removal-of-ozonation-products-of-pharmaceuticals-in-laboratory-moving-bed-biofilm-reactors-mbbrs
#7
Haitham El-Taliawy, Monica Escola Casas, Kai Bester
The major pathway of pharmaceuticals from urban applications to urban surface waters is via wastewater treatment plants. Ozonation is able to remove pharmaceuticals from wastewater effluents. However, during that reaction, ozonation products are formed. Some ozonation products were found to be persistent and have adverse effect on the environment. Moving bed bio reactors (MBBRs) were tested for the removal of the ozonation products of macrolide antibiotics and diclofenac at two different concentration levels 1 μg/L and 10 μg/L in laboratory reactors...
January 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29327191/iron-impregnated-zeolite-catalyst-for-efficient-removal-of-micropollutants-at-very-low-concentration-from-meurthe-river
#8
Hawraa Ayoub, Thibault Roques-Carmes, Olivier Potier, Bachar Koubaissy, Steve Pontvianne, Audrey Lenouvel, Cédric Guignard, Emmanuel Mousset, Hélène Poirot, Joumana Toufaily, Tayssir Hamieh
In this paper, for the first time, faujasite Y zeolite impregnated with iron (III) was employed as a catalyst to remove a real cocktail of micropollutants inside real water samples from the Meurthe river by the means of the heterogeneous photo-Fenton process. The catalyst was prepared by the wet impregnation method using iron (III) nitrate nonahydrate as iron precursor. First, an optimization of the process parameters was conducted using phenol as model macro-pollutant. The hydrogen peroxide concentration, the light wavelength (UV and visible) and intensity, the iron loading immobilized, as well as the pH of the solution were investigated...
January 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29325823/photo-geno-toxicity-changes-associated-with-hydroxylation-of-the-aromatic-chromophores-during-diclofenac-metabolism
#9
Guillermo Garcia-Lainez, Ana M Martínez-Reig, Daniel Limones-Herrero, M Consuelo Jiménez, Miguel A Miranda, Inmaculada Andreu
Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order to avoid these side effects. However, previous studies have shown that DCF, in combination with sunlight, displays capability to induce photosensitivity disorders. In humans, DCF is biotransformed into hydroxylated metabolites at positions 4' and 5 (4'OH-DCF and 5OH-DCF), and this chemical change produces non negligible alterations of the drug chromophore, resulting in a significant modification of its light-absorbing properties...
January 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29320568/gastrointestinal-safety-of-etoricoxib-in-osteoarthritis-and-rheumatoid-arthritis-a-meta-analysis
#10
Xiaoting Feng, Mei Tian, Wei Zhang, Hong Mei
OBJECTIVE: To ascertain if etoricoxib increases the risk of gastrointestinal adverse events (GAEs) compared with placebo, diclofenac, and naproxen in the treatment of patients with osteoarthritis (OA) or rheumatoid arthritis (RA). METHODS: Studies were searched in MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials from inception to August 2017. Randomized Clinical Trials (RCTs) that compared etoricoxib with placebo and other active drug for patients with OA or RA and reported data on gastrointestinal safety (which is of interest to patients and clinicians) were included...
2018: PloS One
https://www.readbyqxmd.com/read/29319909/inhibitory-effects-of-sulfonylureas-and-non-steroidal-anti-inflammatory-drugs-on-in-vitro-metabolism-of-canagliflozin-in-human-liver-microsomes
#11
Sara Algeelani, Dalal Alkhelb, David J Greenblatt
Canagliflozin, used to treat type 2 diabetes mellitus (T2DM), is commonly co-administered with sulfonylureas. The objective of the present study was to evaluate the possible inhibitory effect of sulfonylureas and non-steroidal anti-inflammatory drugs (NSAIDs) on canagliflozin metabolism in vitro. Three sulfonylurea derivatives were evaluated as inhibitors: chlorpropamide, glimepiride, and gliclazide. Two other NSAIDs were used as positive control inhibitors: niflumic acid and diclofenac. The rate of formation of canagliflozin metabolites was determined by HPLC analysis of vitro incubations of canagliflozin as a substrate with and without inhibitors, using human liver microsomes (HLMs)...
January 10, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29319220/drug-induced-micelle-to-vesicle-transition-of-a-cationic-gemini-surfactant-potential-applications-in-drug-delivery
#12
Sargam M Rajput, Sugam Kumar, Vinod K Aswal, Omar El Seoud, Naved Anjum I Malek, Suresh Kumar Kailasa
The impetus for the sustained interest in the formation of vesicles is their potential application as efficient drug delivery systems. A simple approach for ionic surfactants is to add a vesicle-inducing drug of opposite charge. In ionic gemini surfactants (GS) two molecules are covalently linked with a "spacer". Considering drug-delivery, GS are more attractive candidates than their single-chain counterparts because of their high surface activity and the effect on the physico-chemical properties of their solutions caused by changing the length of the spacer, and inclusion of heteroatoms therein...
January 10, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29316592/the-addition-of-diclofenac-to-a-multimodal-pain-control-regimen-decreases-postoperative-pain-and-opioid-consumption
#13
Nicole E George, Cheryle Gurk-Turner, Jennifer I Etcheson, Chukwuweike U Gwam, Randal De Souza, Spencer S Smith, James Nace, Ronald E Delanois
INTRODUCTION: Total knee arthroplasty (TKA) is a commonly-performed orthopaedic procedure in the United States. However, inadequate postoperative pain management following TKA has been associated with a number of negative consequences, including chronic postoperative pain requiring long-term opioid use. Multimodal pain control is a recently-popularized means of maximizing analgesia and postoperative outcomes. We aimed to evaluate the outcomes of a multimodal pain regimen incorporating diclofenac, including: 1) length of stay (LOS); 2) pain intensity; and 3) opioid consumption in primary TKA patients...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29314595/fabrication-and-characterization-of-polymer-ceramic-nanocomposites-containing-drug-loaded-modified-halloysite-nanotubes
#14
Maedeh Ghaderi-Ghahfarrokhi, Vahid Haddadi-Asl, Seyed Shahrooz Zargarian
Modified halloysite nanotubes (HNT-NH2 and HNT-COOH) were synthesized by a coupling reaction with 3-amino- propyltriethoxysilane (APTES) and maleic anhydride from hydroxyl groups of neat halloysite nanotubes (HNTs). Successful attachment of functional groups onto HNTs was evaluated by FTIR and TGA. XRD was used to study the crystalline structure of scaffolds and the formation of intercalated structure as a result of improved dispersion and decreased agglomeration of modified nanoparticles. Neat HNT, HNT-NH2 and HNT-COOH were subsequently introduced into Polycaprolactone/Pluronic P123 (PCL/P123) electrospun substrate...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314177/assessment-of-the-antinociceptive-and-ulcerogenic-activity-of-the-tapentadol-diclofenac-combination-in-rodents
#15
Juan R Zapata-Morales, Ángel J Alonso-Castro, Vinicio Granado-Soto, Sergio Sánchez-Enriquez, Mario A Isiordia-Espinoza
Preclinical Research & Development The objective of the present study was to evaluate the tapentadol-diclofenac combination in three dose-ratios in the mouse acetic acid-induced visceral pain and their ulcerogenic activity on the stomachal mucous. Dose-response curves were generated for tapentadol, diclofenac, and their combination in the acetic acid-induced writhing test in mice. Moreover, the stomachs of animals were surgically removal and gastrointestinal ulcerogenic action of the combination was assessed...
January 3, 2018: Drug Development Research
https://www.readbyqxmd.com/read/29306107/leukemia-cells-impair-normal-hematopoiesis-and-induce-functionally-loss-of-hematopoietic-stem-cells-through-immune-cells-and-inflammation
#16
Ping Cui, Yuhua Zhang, Maoxiang Cui, Zhihong Li, Guang Ma, Rufeng Wang, Ning Wang, Shujuan Huang, Jie Gao
Bone marrow (BM) failure is often seen in leukemia patients, indicating an abnormal hematopoietic process. However, hematopoiesis in leukemic milieus is largely unknown. In the present study, we utilized one of the most frequent leukemogenic translocations MLL-AF9 to induce leukemia and investigated the hematopoiesis and the activity of hematopoietic stem and progenitor cells (HSPCs) in a leukemic milieu. We found that the phenotypes of the non-leukemic population in leukemic BM were drastically different than normal BM, including blockage of differentiation and a drastically reduced Lin-/Sca+/c-kit+ (LSK) population that contains all HSPCs in leukemic BM...
January 2, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29305792/analgesic-effect-of-intraperitoneal-bupivacaine-hydrochloride-after-laparoscopic-sleeve-gastrectomy-a-randomized-clinical-trial
#17
Nasser Malekpour Alamdari, Mahmood Bakhtiyari, Barmak Gholizadeh, Catrine Shariati
BACKGROUND: The indications for sleeve gastrectomy as a primary procedure for the surgical treatment of morbid obesity have increased worldwide. Pain is the most common complaint for patients on the first day after laparoscopic sleeve gastrectomy. There are various methods for decreasing pain after laparoscopic sleeve gastrectomy such as the use of intraperitoneal bupivacaine hydrochloride. This clinical trial was an attempt to discover the effects of intraperitoneal bupivacaine hydrochloride on alleviating postoperative pain after laparoscopic sleeve gastrectomy...
January 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29304875/antinociceptive-tolerance-to-nsaids-in-the-anterior-cingulate-cortex-is-mediated-via-endogenous-opioid-mechanism
#18
Nana Tsiklauri, Natia Pirkulashvili, Ivliane Nozadze, Marina Nebieridze, Gulnaz Gurtskaia, Elene Abzianidze, Merab G Tsagareli
BACKGROUND: In the past decade several studies have reported that in some brain areas, particularly, in the midbrain periaqueductal gray matter, rostral ventro-medial medulla, central nucleus of amygdala, nucleus raphe magnus, and dorsal hippocampus, microinjections of non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of tolerance. Given this evidence, in this study we investigated the development of tolerance to the analgesic effects of NSAIDs diclofenac, ketorolac and xefocam microinjected into the rostral part of anterior cingulate cortex (ACC) in rats...
January 6, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29304464/monitoring-the-occurrence-of-pharmaceuticals-in-soils-irrigated-with-reclaimed-wastewater
#19
Miriam Biel-Maeso, Carmen Corada-Fernández, Pablo A Lara-Martín
The use of reclaimed wastewater for irrigation is foreseen as a possible strategy to mitigate the pressure on water resources in dry regions. However, there is the risk of potential accumulation of contaminants of emerging concern (CECs) in the edaphic environment, their percolation and consequently contamination of aquifers. In the present study, we measured the levels of a wide range of commonly used pharmaceutically active compounds (PhACs) in sewage from a local wastewater treatment plant (WWTP) and in soils irrigated with treated wastewater...
January 2, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29303776/evaluation-of-morning-glory-jacquemontia-tamnifolia-l-griseb-leaves-for-antioxidant-antinociceptive-anticoagulant-and-cytotoxic-activities
#20
Mohammad Shahadat Hossain, A S M Ali Reza, Md Masudur Rahaman, Mst Samima Nasrin, Mohammed Rasib Uddin Rahat, Md Rabiul Islam, Md Josim Uddin, Md Atiar Rahman
BACKGROUND: The present study was planned to investigate the phytochemical, antioxidant, antinociceptive, anticoagulant and cytotoxic activities of the Jacquemontia tamnifolia (L.) Griseb leaf methanol extract (MExJT) in the laboratory using both in vitro and in vivo methods. METHODS: Phytochemical values, namely, total phenolic and flavonoid contents, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect and FeCl3 reducing power effects, were studied by established methods...
January 5, 2018: Journal of Basic and Clinical Physiology and Pharmacology
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