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https://www.readbyqxmd.com/read/28715127/increased-aggression-and-lack-of-maternal-behavior-in-dio3-deficient-mice-are-associated-with-abnormalities-in-oxytocin-and-vasopressin-systems
#1
J Patrizia Stohn, M Elena Martinez, Maryam Zafer, Daniela López-Espíndola, Lauren M Keyes, Arturo Hernandez
Thyroid hormones regulate many aspects of brain development and function, and alterations in the levels of thyroid hormone action lead to abnormal anxiety- and depression-like behaviors. A complement of factors in the brain function independently of circulating levels of hormone to strictly controlled local thyroid hormone signaling. A critical factor is the type 3 deiodinase (DIO3), which is located in neurons and protects the brain from excessive thyroid hormone. Here we examined whether a local increase in brain thyroid hormone action secondary to DIO3 deficiency is of consequence for social behaviors...
July 17, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28714321/zoophilia-in-an-adolescent-with-high-functioning-autism-from-sri-lanka
#2
Miyuru Chandradasa, Layani Champika
OBJECTIVE: Zoophilia is a rare paraphilic disorder with intense sexual urges involving animals. Autism is characterised by impairments in social communication and repetitive, restricted behaviours (RRB). Reported cases of zoophilia are limited worldwide, and zoophilia in autism is rarer. METHOD: This is a case report describing this unique and relatively unrecognised association in a male adolescent from Sri Lanka. RESULTS: A 17-year-old boy diagnosed with autism has average intelligence and academic capabilities...
July 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28711745/child-maltreatment-and-age-of-alcohol-and-marijuana-initiation-in-high-risk-youth
#3
Laura J Proctor, Terri Lewis, Scott Roesch, Richard Thompson, Alan J Litrownik, Diana English, Amelia M Arria, Patricia Isbell, Howard Dubowitz
INTRODUCTION: Youth with a history of child maltreatment use substances and develop substance use disorders at rates above national averages. Thus far, no research has examined pathways from maltreatment to age of substance use initiation for maltreated youth. We examined the longitudinal impact of maltreatment in early childhood on age of alcohol and marijuana use initiation, and whether internalizing and externalizing behaviors at age 8 mediates the link between maltreatment and age of substance use initiation...
June 30, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28711608/do-anabolic-androgenic-steroids-have-performance-enhancing-effects-in-female-athletes
#4
REVIEW
Grace Huang, Shehzad Basaria
Doping with anabolic androgenic steroids (AAS) is common among both male and female athletes and is a growing public health problem. Review of historical data of systematic state-sponsored doping programs implemented by the German Democratic Republic in elite female athletes and from the clinical trials of testosterone administration in non-athlete women suggests that AAS have ergogenic effects in women. The use of AAS in female athletes has been associated with adverse effects that include acne, hirsutism, deepening of the voice and menstrual disturbances; life-threatening adverse effects such as cardiac arrhythmias and sudden death have also been reported...
July 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28701997/early-intranasal-vasopressin-administration-impairs-partner-preference-in-adult-male-prairie-voles-microtus-ochrogaster
#5
Trenton C Simmons, Jessica F Balland, Janeet Dhauna, Sang Yun Yang, Jason L Traina, Jessica Vazquez, Karen L Bales
Research supports a modulatory role for arginine vasopressin (AVP) in the expression of socially motivated behaviors in mammals. The acute effects of AVP administration are demonstrably pro-social across species, providing the justification for an ever-increasing measure of clinical interest over the last decade. Combining these results with non-invasive intranasal delivery results in an attractive system for offering intranasal AVP (IN-AVP) as a therapeutic for the social impairments of children with autism spectrum disorder...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28701272/sexually-transmitted-infections-challenges-ahead
#6
REVIEW
Magnus Unemo, Catriona S Bradshaw, Jane S Hocking, Henry J C de Vries, Suzanna C Francis, David Mabey, Jeanne M Marrazzo, Gerard J B Sonder, Jane R Schwebke, Elske Hoornenborg, Rosanna W Peeling, Susan S Philip, Nicola Low, Christopher K Fairley
WHO estimated that nearly 1 million people become infected every day with any of four curable sexually transmitted infections (STIs): chlamydia, gonorrhoea, syphilis, and trichomoniasis. Despite their high global incidence, STIs remain a neglected area of research. In this Commission, we have prioritised five areas that represent particular challenges in STI treatment and control. Chlamydia remains the most commonly diagnosed bacterial STI in high-income countries despite widespread testing recommendations, sensitive and specific non-invasive testing techniques, and cheap effective therapy...
July 7, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28700808/the-moderating-effect-of-childhood-maltreatment-on-the-relations-among-ptsd-symptoms-positive-urgency-and-negative-urgency
#7
Matthew Price, Julie P Connor, Holley C Allen
Childhood maltreatment increases the risk for posttraumatic stress disorder (PTSD) and comorbid substance use disorder (SUD). One pathway by which this occurs is through impaired emotion regulation. Past research has shown that negative urgency, a deficit in the regulation of negative emotions, is strongly related to PTSD in those with comorbid SUD. However, there is minimal research on the relation between positive urgency and PTSD in those with comorbid SUD. The current study investigated the association between childhood maltreatment, positive urgency, negative urgency, and PTSD symptoms among those with SUD...
July 12, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28700391/human-t-lymphotropic-virus-type-1-infection-and-disease-in-spain
#8
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from men to women) and parenterally (transfusions, injection drug user (IDU), and transplants)...
July 31, 2017: AIDS
https://www.readbyqxmd.com/read/28694574/clitoral-choristoma-a-rare-case-report
#9
Jayalaxmi Shripati Aihole, Hemalatha Lokanath, M Narendra Babu, J Deepak
Clitoral hypertrophy is usually seen as a congenital malformation, specifically during the stages of hormonal expressions in the disorders of sexual development. Acquired clitoral hypertrophy is a relatively rare condition. Clitoris can be the site of neoplastic lesions. Clitoral choristoma has not been reported so far in the literature.
July 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28691307/socio-sexual-functioning-in-autism-spectrum-disorder-a-systematic-review-and-meta-analyses-of-existing-literature
#10
Grace I P Hancock, Mark A Stokes, Gary B Mesibov
Socio-sexual functioning encompasses an individual's interests, behaviors, and knowledge with respect to sexual, romantic, and social aspects of life. An individual's understanding of these domains is developed through a range of informal and formal avenues of sexual health education. The current model demonstrated this and proposed that, compared to typically developing individuals, those with ASD develop socio-sexual functioning differently due to having less peer engagement, less relationship experience, more parental guidance, greater use of online materials, receive less school-based sexual health education, and more support from wellbeing services...
July 10, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28690896/late-diagnosis-of-5-%C3%AE-reductase-type-2-deficiency-in-an-adolescent-girl-with-primary-amenorrhoea
#11
Abdul-Rahman A Hummadi, Ayel O Yahya, Awad M Al-Qahtani
Deficiency of the 5-α-reductase enzyme has been found to affect male sexual development. We report an 18-year-old patient who was referred to an endocrinology clinic in Jizan, Saudi Arabia, in April 2014 with primary amenorrhoea, virilisation and a lack of secondary sex characteristics. As female external genitalia were present at birth, she had been raised as a female. Magnetic resonance imaging revealed no uterine or ovarian tissue in the pelvis and the presence of a scrotal sac. She was diagnosed with 5-α-reductase type 2 deficiency, a 46,XY disorder of sexual development...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28687897/hypersexuality-a-critical-review-and-introduction-to-the-sexhavior-cycle
#12
Michael T Walton, James M Cantor, Navjot Bhullar, Amy D Lykins
An empirical review of hypersexuality is timely as "compulsive sexual behavior" is being considered as an impulse control disorder for inclusion in the forthcoming International Classification of Diseases, 11th ed. Specifically, hypersexuality has been conceptualized in the literature as the inability to regulate one's sexual behavior that is a source of significant personal distress. Various theoretical models have been posited in an attempt to understand the occurrence of hypersexuality, although disagreement about these divergent conceptualizations of the condition has made assessment and treatment of hypersexual clients more challenging...
July 7, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28682782/pubertal-assessment-a-national-survey-of-attitudes-knowledge-and-practices-of-the-us-pediatric-trainees
#13
Aditi Khokhar, Yagnaram Ravichandran, Dimitre G Stefanov, Sheila Perez-Colon
Background and objective Sex maturity rating (SMR), defines different levels of sexual maturity, based on the development of secondary sexual characteristics. Periodic assessment of pubertal maturation by physicians is crucial for timely identification of puberty-related disorders. With this pilot study, we aimed to assess the attitudes, knowledge and practices of pubertal assessment by current US pediatric trainees. Methods An anonymous online survey questionnaire was sent to categorical pediatric residents at different levels of training and pediatric chief residents across the US...
July 6, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28682451/outcomes-for-patients-with-apparent-chronic-idiopathic-pelvic-pain-and-associated-pelvic-floor-disorders-undergoing-laparoscopic-ventral-mesh-rectopexy
#14
A Newman, G L Greenslade, K McCarthy, A R Dixon
AIM: To assess the outcomes for patients with chronic idiopathic pelvic pain (CIPP) and associated pelvic floor disorders (PFDs) undergoing laparoscopic ventral mesh rectopexy (LVMR). METHOD: A prospective database identified patients referred from a specialist pain clinic undergoing LVMR. Primary outcomes included numerical rating scale (NRS) for pain, quality of life (QoL), Wexner constipation score, Cleveland Clinic incontinence score (CCIS), bowel and bladder-disturbance visual analogue scale (VAS) pain score and sexual function...
July 6, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28681684/association-splitting-of-the-sexual-orientation-ocd-relevant-semantic-network
#15
Terence H W Ching, Monnica T Williams
There is little research on treating symptoms of sexual orientation-obsessive-compulsive disorder (SO-OCD). Semantic networks represent a new cognitive approach for understanding cognitive mechanisms of SO-OCD. Specifically, we tested whether the self-help cognitive technique of association splitting (AS) developed from this approach would be efficacious in reducing SO-OCD symptoms and thought suppression. One hundred and twenty heterosexual undergraduates (82 females, 38 males) were randomly assigned to either the AS or waitlist control group...
July 6, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28677910/factors-associated-with-progression-in-the-london-pathway-project
#16
Darrick Jolliffe, Jack Cattell, Annabelle Raza, Philip Minoudis
BACKGROUND: The London Pathways Partnership (LPP) Community Service is an approach to mainstreaming the identification of offenders with severe personality disorder to address their needs and reduce their risk. AIMS: To evaluate the result of the full-scale implementation of the LPP and evaluate factors associated with an offender's progression on the pathway. METHOD: The data collected as part of the LPP project and Offender Assessment System data were used to evaluate who was screened into the pathway and their progression on the pathway...
July 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/28667832/effect-of-previous-posttraumatic-stress-in-the-perinatal-period
#17
Pamela A Geller, Emily C Stasko
OBJECTIVE: To review the extant literature on the effect of traumatic experiences that pre-date conception, pregnancy, and the postpartum period (perinatal period) and present a thematic overview of current issues in this relatively new area of inquiry. DATA SOURCES: Electronic databases CINAHL, PsychINFO, and PubMed were searched. Manual searches of bibliographies supplemented the electronic search. STUDY SELECTION: Peer-reviewed articles written in English on the role of posttraumatic stress disorder during the perinatal period were included...
June 28, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28666836/flibanserin-efficacy-and-safety-in-premenopausal-women-with-generalized-acquired-hypoactive-sexual-desire-disorder
#18
REVIEW
William A Fisher, Robert E Pyke
INTRODUCTION: Flibanserin is a postsynaptic 5-HT-1A agonist and 5-HT-2A antagonist for the treatment of generalized acquired hypoactive sexual desire disorder in premenopausal women. AIM: To review and evaluate the efficacy and safety of flibanserin. METHODS: We review and critique the appropriateness of the co-primary and secondary end points used in the flibanserin pivotal trial research program. We review the efficacy and safety parameters of this drug based on the published literature and related sources...
June 27, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28660406/evaluation-of-potentially-prolactin-related-adverse-events-and-sexual-maturation-in-adolescents-with-schizophrenia-treated-with-paliperidone-extended-release-er-for-2-years-a-post-hoc-analysis-of-an-open-label-multicenter-study
#19
Srihari Gopal, Rosanne Lane, Isaac Nuamah, Margaret Copenhaver, Jaskaran Singh, David Hough, Mark Bach, Adam Savitz
BACKGROUND: Elevated prolactin levels (hyperprolactinemia) are a frequent adverse effect of antipsychotic medications, especially in young populations. Prolonged hyperprolactinemia may affect sexual functioning and the onset and progression of puberty. OBJECTIVE: This study assessed potentially prolactin-related treatment-emergent adverse events (PPRL-TEAEs) and sexual maturation during long-term treatment of adolescents with paliperidone extended-release (ER). METHODS: This post hoc analysis of a 2-year open-label multicenter study (NCT00488319) included patients of either sex aged 12-17 years at study enrollment, diagnosed with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV]) for ≥1 year, who had received one or more adequate antipsychotic treatment prior to enrollment but had not responded sufficiently...
June 28, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28642048/sexual-consequences-of-post-ssri-syndrome
#20
REVIEW
Yacov Reisman
INTRODUCTION: Sexual dysfunctions are well-known side effects of selective serotonin reuptake inhibitor (SSRI) use. Altered libido, erectile dysfunction, vaginal dryness, ejaculatory disorders, and orgasmic problems are frequently reported by patients treated with SSRIs. Moreover, these antidepressant-emergent sexual dysfunctions do not always resolve after discontinuation of the medication and can persist indefinitely. These complaints are termed post-SSRI sexual dysfunctions (PSSD)...
June 19, 2017: Sexual Medicine Reviews
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