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https://www.readbyqxmd.com/read/27932749/-hemorrhage-from-an-angiographically-obliterated-arteriovenous-malformation-after-gamma-knife-radiosurgery-an-immunohistochemistry-study
#1
Saori Hamada, Daina Kashiwazaki, Tetsuhiro Kamo, Takahiro Tomita, Naoki Akioka, Naoya Kuwayama, Satoshi Kuroda
A 24-year-old woman was diagnosed with a cerebral arteriovenous malformation(AVM)in the right parietal lobe(Spetzler-Martin grade I). The AVM was treated with stereotactic radiosurgery and was observed to have completely disappeared 3 years after radiosurgery. At the age of 35 years, the patient complained of a headache, and was referred to our hospital. A plain CT scan demonstrated a large cyst with niveau formation in the right parietal lobe. Cerebral angiography identified no recurrence of AVM. However, contrast MRI revealed an enhanced lesion on the surface of the cyst...
December 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27923749/spinal-glomus-arteriovenous-malformation-presenting-with-a-subarachnoid-hemorrhage
#2
Pascal Jabbour, Badih Daou, Elias Atallah, Fadi Al-Saiegh, Kenan Alkhalili, Stavropoula Tjoumakaris
BACKGROUND AND IMPORTANCE: Spinal arteriovenous malformations (AVMs) are rare lesions that may cause serious neurologic morbidity. With the developments in endovascular technology and embolic materials, endovascular management of spinal AVMs has gained significant popularity. CLINICAL PRESENTATION: A 61-year-old female presented with the worst headache of her life, associated with an acute onset of nausea and vomiting and was shown to have a grade 2 subarachnoid hemorrhage on CT scan...
December 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27903187/stereotactic-diffusion-tensor-imaging-tractography-for-gamma-knife-radiosurgery
#3
Cormac G Gavin, H Ian Sabin
OBJECTIVE The integration of modern neuroimaging into treatment planning has increased the therapeutic potential and safety of stereotactic radiosurgery. The authors report their method of integrating stereotactic diffusion tensor imaging (DTI) tractography into conventional treatment planning for Gamma Knife radiosurgery (GKRS). The aim of this study was to demonstrate the feasibility of this technique and to address some of the technical limitations of previously reported techniques. METHODS Twenty patients who underwent GKRS composed the study cohort...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27903180/results-of-volume-staged-fractionated-gamma-knife-radiosurgery-for-large-complex-arteriovenous-malformations-obliteration-rates-and-clinical-outcomes-of-an-evolving-treatment-paradigm
#4
Alberto Franzin, Pietro Panni, Giorgio Spatola, Antonella Del Vecchio, Alberto L Gallotti, Carmen R Gigliotti, Andrea Cavalli, Carmine A Donofrio, Pietro Mortini
OBJECTIVE There are few reported series regarding volume-staged Gamma Knife radiosurgery (GKRS) for the treatment of large, complex, cerebral arteriovenous malformations (AVMs). The object of this study was to report the results of using volume-staged Gamma Knife radiosurgery for patients affected by large and complex AVMs. METHODS Data from 20 patients with large AVMs were prospectively included in the authors' AVM database between 2004 and 2012. A staging strategy was used when treating lesion volumes larger than 10 cm(3)...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27899758/estimating-the-risks-of-adverse-radiation-effects-after-gamma-knife-radiosurgery-for-arteriovenous-malformations
#5
Hideyuki Kano, John C Flickinger, Daniel Tonetti, Alan Hsu, Huai-Che Yang, Thomas J Flannery, Ajay Niranjan, L Dade Lunsford
BACKGROUND AND PURPOSE: We evaluated risk factors associated with the development of adverse radiation effects (ARE) after stereotactic radiosurgery (SRS) for cerebral arteriovenous malformations (AVMs). METHODS: We evaluated 755 patients with AVM who underwent a single Gamma Knife SRS procedure with at least a 2-year minimum follow-up. Eighty-seven patients (12%) underwent previous resection and 128 (17%) had previous embolization. The median target volume was 3...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27878793/novel-cases-of-amyotrophic-lateral-sclerosis-after-treatment-of-cerebral-arteriovenous-malformationss
#6
Michael Linnebank, Cameron G McDougall, Stefanie Krueger, Saskia Biskup, Manuela Neumann, Michael Weller, Antonios Valavanis, Johannes Prudlo
Previous case studies reported nine patients with cerebral arteriovenous malformations (AVM) who developed amyotrophic lateral sclerosis (ALS) after AVM embolisation. Here, we describe three novel cases of ALS which developed 13-34 years after treatment, including embolisation, of cerebral AVM. This study provides further arguments supporting the thesis that embolisation of cerebral AVM might influence the risk of later ALS development.
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27869147/interplay-between-vegf-and-nrf2-regulates-angiogenesis-due-to-intracranial-venous-hypertension
#7
Liwen Li, Hao Pan, Handong Wang, Xiang Li, Xiaomin Bu, Qiang Wang, Yongyue Gao, Guodao Wen, Yali Zhou, Zixiang Cong, Youqing Yang, Chao Tang, Zhengwei Liu
Venous hypertension(VH) plays an important role in the pathogenesis of cerebral arteriovenous malformations (AVMs) and is closely associated with the HIF-1α/VEGF signaling pathway. Nuclear factor erythroid 2-related factor 2(Nrf2) significantly influences angiogenesis; however, the interplay between Nrf2 and VEGF under VH in brain AVMs remains unclear. Therefore, our study aimed to investigate the interplay between Nrf2 and VEGF due to VH in brain AVMs. Immunohistochemistry indicated that Nrf2 and VEGF were highly expressed in human brain AVM tissues...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27866455/changes-in-pulsatility-and-resistance-indices-of-cerebral-arteriovenous-malformation-feeder-arteries-after-embolization-and-surgery
#8
Sophia F Shakur, Sepideh Amin-Hanjani, Mohamed Abouelleil, Victor A Aletich, Fady T Charbel, Ali Alaraj
OBJECTIVES: Embolization reduces flow in cerebral arteriovenous malformations (AVMs) before surgical resection, but changes in pulsatility and resistance indices (PI, RI) are unknown. Here, we measure PI, RI in AVM arterial feeders before and after embolization/surgery. METHODS: Records of patients who underwent AVM embolization and surgical resection at our institution between 2007 and 2014 and had PI, RI, and flows obtained using quantitative magnetic resonance angiography were retrospectively reviewed...
November 21, 2016: Neurological Research
https://www.readbyqxmd.com/read/27864523/carotid-artery-web-and-ischemic-stroke-a-case-control-study
#9
Jonathan M Coutinho, Sheldon Derkatch, Alphonse R J Potvin, George Tomlinson, Leanne K Casaubon, Frank L Silver, Daniel M Mandell
OBJECTIVE: To determine whether there is an association between carotid artery web and ischemic stroke. METHODS: This was a single-center, age- and sex-matched, case-control study. Cases were consecutive patients with anterior circulation ischemic stroke of undetermined etiology (Trial of Org 10172 in Acute Stroke Treatment [TOAST] classification). Controls were consecutive patients with cerebral aneurysms, arteriovenous malformations, or primary intracerebral hemorrhages...
November 18, 2016: Neurology
https://www.readbyqxmd.com/read/27835916/neuropsychological-performance-after-brain-arteriovenous-malformations-treatment
#10
Ondrej Bradac, Alice Pulkrabkova, Patricia de Lacy, Vladimir Benes
Background The treatment of brain arteriovenous malformations (AVMs) has been studied extensively. With the use of the Spetzler-Martin (S-M) grading system, patients can be informed appropriately about their possible surgical risks. This does not hold true for their neuropsychological sequelae, which have not been studied widely. We evaluated the neuropsychological outcome of our patients treated for brain AVMs. Methods Of 113 patients treated for a brain AVM between 2001 and 2009, 66 patients were enrolled in the study...
November 11, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27821474/the-dual-microcatheter-technique-for-transvenous-embolization-of-dural-arteriovenous-fistulae
#11
Isaac Josh Abecassis, John D Nerva, Basavaraj V Ghodke, Laligam N Sekhar, Michael R Levitt, Louis J Kim
BACKGROUND: Dural arteriovenous fistulae (dAVFs) comprise 10-15% of all intracranial arteriovenous malformations. The goal of surgical or endovascular intervention is complete obliteration of the fistulous connection(s). In cases where dAVF venous drainage is separate from normal cortical drainage, transvenous embolization can provide fast and effective fistula obliteration. OBJECTIVE: To describe a new method of efficient transvenous embolization (the 'dual microcatheter technique') for the treatment of dAVFs...
November 7, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27821297/validity-assessment-of-grading-scales-predicting-complications-from-embolization-of-cerebral-arteriovenous-malformations
#12
Raghav Gupta, Nimer Adeeb, Justin M Moore, Rouzbeh Motiei-Langroudi, Christoph J Griessenauer, Apar S Patel, Christopher S Ogilvy, Ajith J Thomas
OBJECTIVE: Endovascular embolization, though initially approved as an adjunctive therapy for surgical excision of cerebral arteriovenous malformations (AVMs), has found extensive use in the management of these lesions. A number of systems have been proposed to stratify AVMs by the procedural risk of embolization, including the Buffalo score and AVM Neuroendovascular grade. An external validity assessment of these systems has not been performed. PATIENTS AND METHODS: A retrospective review of all patients who underwent embolization of cerebral AVMs at a single institution, between 2010 and 2016, was performed...
December 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27815963/the-management-of-symptomatic-cerebral-developmental-venous-anomalies-a-clinical-experience-of-43-cases
#13
Xin-Guang Yu, Chen Wu, Hui Zhang, Zheng-Hui Sun, Zhi-Qiang Cui
BACKGROUND Developmental venous anomalies (DVAs) are rare vascular diseases becoming more frequently diagnosed. Most patients with DVAs have no clinical symptoms with the exception of a few patients with epilepsy, intracranial hemorrhage, or neuro-function deficit. There is still controversy with respect to treatment strategies for symptomatic DVAs. MATERIAL AND METHODS Forty-three cases of symptomatic DVAs from January 2006 to October 2015 were retrospectively reviewed and the imaging characteristics of DVAs by CT, MRI, and DSA and the treatment modalities for DVAs were studied...
November 5, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27814895/effect-of-center-volume-on-outcomes-in-hospitalized-patients-with-hereditary-hemorrhagic-telangiectasia
#14
Vivek N Iyer, Waleed Brinjikji, Bibek S Pannu, Dinesh R Apala, Giuseppe Lanzino, Harry J Cloft, Sanjay Misra, Michael J Krowka, Christopher P Wood, Karen L Swanson
OBJECTIVE: To determine whether hospitalized patients with hereditary hemorrhagic telangiectasia (HHT) had better outcomes at high-volume treatment centers (HVCs). PATIENTS AND METHODS: The Nationwide Inpatient Sample (2000-2011) was used to identify HHT-related hospitalizations. Hospitals were classified based on quartiles of annual HHT discharge volume. The 75th percentile cutoff value (third quartile) was used to classify hospitals as low-volume centers (1-7 HHT discharges per year) or as HVCs (≥8 discharges per year...
November 1, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27811496/a-case-report-of-onyx-pulmonary-arterial-embolism-contributing-to-hypoxemia-during-awake-craniotomy-for-arteriovenous-malformation-resection
#15
Brian T Tolly, Jenna L Kosky, Antoun Koht, Laura B Hemmer
A healthy 26-year-old man with cerebral arteriovenous malformation underwent staged endovascular embolization with Onyx followed by awake craniotomy for resection. The perioperative course was complicated by tachycardia and severe intraoperative hypoxemia requiring significant oxygen supplementation. Postoperative chest computed tomography (CT) revealed hyperattenuating Onyx embolization material within the pulmonary vasculature, and an electrocardiogram indicated possible right heart strain, supporting clinically significant embolism...
November 2, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27806123/time-staged-gamma-knife-stereotactic-radiosurgery-for-large-cerebral-arteriovenous-malformations-a-preliminary-report
#16
Hye Ran Park, Jae Meen Lee, Jin Wook Kim, Jung-Ho Han, Hyun-Tai Chung, Moon Hee Han, Dong Gyu Kim, Sun Ha Paek
OBJECTIVE: We retrospectively analyzed our experience with time-staged gamma knife stereotactic radiosurgery (GKS) in treating large arteriovenous malformation(AVM)s;≥ 10 cm3). METHODS: Forty-five patients who underwent time-staged GKS (2-stage, n = 37;3-stage,n = 8) between March 1998 and December 2011 were included. The mean volume treated was 20.42±6.29 cm3 (range, 10.20-38.50 cm3). Obliteration rates of AVMs and the associated complications after GKS were evaluated...
2016: PloS One
https://www.readbyqxmd.com/read/27790398/preoperative-embolization-of-cerebral-arteriovenous-malformations-with-silk-suture-and-particles-technical-considerations-and-outcomes
#17
Jordan R Conger, Dale Ding, Daniel M Raper, Robert M Starke, Christopher R Durst, Kenneth C Liu, Mary E Jensen, Avery J Evans
OBJECTIVE: Embolization of cerebral arteriovenous malformations (AVMs) is commonly performed prior to surgical resection in order to reduce intraoperative bleeding and improve the safety of resection. Although most modern embolization procedures utilize permanent embolic agents, silk suture and polyvinyl alcohol (PVA) particles may offer unique advantages for preoperative devascularization. The aims of this retrospective cohort study are to describe the technical considerations and determine the outcomes for preoperative silk suture and PVA particle embolization (SPE) of AVMs...
June 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27787648/cerebrofacial-arteriovenous-metameric-syndrome-cams-a-spectrum-disorder-of-craniofacial-vascular-malformations
#18
Lauren O'Loughlin, Mari L Groves, Neil R Miller, Monica S Pearl
Cerebrofacial arteriovenous metameric syndrome (CAMS) is a recent classification of vascular malformations that encompasses a spectrum of phenotypic expression involving arteriovenous malformations (AVMs) of the cerebral, orbital, and facial region. Recognizing the embryologic basis of CAMS is important for diagnosing other AVMs along the same metameric level. Visual loss is the most common presentation prompting ophthalmologic evaluation followed by neuroimaging. We present two pediatric patients with ipsilateral optic nerve and chiasmal AVMs without cutaneous manifestations, characteristic of CAMS 2...
October 27, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27767404/prevalence-and-characteristics-of-brain-arteriovenous-malformations-in-hereditary-hemorrhagic-telangiectasia-a-systematic-review-and-meta-analysis
#19
Waleed Brinjikji, Vivek N Iyer, Christopher P Wood, Giuseppe Lanzino
OBJECTIVE Patients with hereditary hemorrhagic telangiectasia (HHT) are known to suffer from high rates of cerebral arteriovenous malformations (AVMs). The authors performed a systematic review and meta-analysis of the literature examining prevalence rates, characteristics, and clinical presentation of cerebral AVMs in the HHT population. METHODS To identify studies on AVM prevalence and characteristics in the HHT population, 4 databases (MEDLINE, EMBASE, Scopus and Web of Science) were searched by a reference librarian with over 30 years experience in systematic reviews and meta-analysis...
October 21, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27766428/multiple-cerebral-arterio-venous-malformations-impact-of-multiplicity-and-hemodynamics-on-treatment-strategies
#20
Klaus-Peter Stein, Isabel Wanke, Neriman Oezkan, Yuan Zhu, I Erol Sandalcioglu, Michael Forsting, Ulrich Sure
BACKGROUND: Multiple AVMs are exceptionally rare lesions and only a few larger series have been published, including other vascular pathologies, such as arterio-venous fistulae (AVF) or patients with hereditary syndromes. Our study presents clinical, angiographic, and therapeutic characteristics of patients harboring sporadic multiple AVMs. METHODS: Basic demographic data, vascular architecture, clinical presentation, treatment strategies, and treatment outcome were analyzed retrospectively from patients with cerebral AVMs treated in our department between 1990 and 2015...
October 20, 2016: Acta Neurochirurgica
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