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https://www.readbyqxmd.com/read/29422840/mechanisms-underlying-serotonergic-excitation-of-callosal-projection-neurons-in-the-mouse-medial-prefrontal-cortex
#1
Emily K Stephens, Arielle L Baker, Allan T Gulledge
Serotonin (5-HT) selectively excites subpopulations of pyramidal neurons in the neocortex via activation of 5-HT2A (2A) receptors coupled to Gq subtype G-protein alpha subunits. Gq-mediated excitatory responses have been attributed primarily to suppression of potassium conductances, including those mediated by KV7 potassium channels (i.e., the M-current), or activation of non-specific cation conductances that underlie calcium-dependent afterdepolarizations (ADPs). However, 2A-dependent excitation of cortical neurons has not been extensively studied, and no consensus exists regarding the underlying ionic effector(s) involved...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29332144/long-acting-%C3%AE-2-agonists-in-asthma-enantioselective-safety-studies-are-needed
#2
Glenn A Jacobson, Sharanne Raidal, Morten Hostrup, Luigino Calzetta, Richard Wood-Baker, Mark O Farber, Clive P Page, E Haydn Walters
Long-acting β2-agonists (LABAs) such as formoterol and salmeterol are used for prolonged bronchodilatation in asthma, usually in combination with inhaled corticosteroids (ICSs). Unexplained paradoxical asthma exacerbations and deaths have been associated with LABAs, particularly when used without ICS. LABAs clearly demonstrate effective bronchodilatation and steroid-sparing activity, but long-term treatment can lead to tolerance of their bronchodilator effects. There are also concerns with regard to the effects of LABAs on bronchial hyperresponsiveness (BHR), where long-term use is associated with increased BHR and loss of bronchoprotection...
January 13, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29323635/mukb-atpases-are-regulated-independently-by-the-n-and-c-terminal-domains-of-mukf-kleisin
#3
Katarzyna Zawadzka, Pawel Zawadzki, Rachel Baker, Karthik V Rajasekar, Florence Wagner, David J Sherratt, Lidia K Arciszewska
The Escherichia coli SMC complex, MukBEF, acts in chromosome segregation. MukBEF shares the distinctive architecture of other SMC complexes, with one prominent difference; unlike other kleisins, MukF forms dimers through its N-terminal domain. We show that a 4-helix bundle adjacent to the MukF dimerization domain interacts functionally with the MukB coiled-coiled 'neck' adjacent to the ATPase head. We propose that this interaction leads to an asymmetric tripartite complex, as in other SMC complexes. Since MukF dimerization is preserved during this interaction, MukF directs the formation of dimer of dimer MukBEF complexes, observed previously in vivo...
January 11, 2018: ELife
https://www.readbyqxmd.com/read/29299555/a-m18l6-metal-organic-nanocapsule-with-open-windows-using-mixed-macrocycles
#4
Chen Zhang, Kanishka Sikligar, Rahul S Patil, Charles L Barnes, Gary A Baker, Jerry L Atwood
We present here the preparation of a M18L6 hexameric metal-organic nanocapsule using a pyrogallol[3]resorcin[1]arene mixed macrocycle. The introduction of resorcinol moieties within the assembly leads to the formation of two open windows. This study demonstrates that introducing defects into the existing structure of nanocapsules may act as an effective method to tailor the composition and geometry, and introduce new properties.
January 4, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29295011/the-association-among-parental-bonding-depression-social-aggression-and-criminal-assault-are-there-gender-differences-between-male-and-female-youth-offenders
#5
John Tisak, Marie S Tisak, Erin R Baker, Kelly E Amrhein, Cjersti Jensen
This research examined similarities and differences in gender regarding social aggression, criminal assault, depression, and familial factors. The participants were 251 youth offenders (158 males) who were arrested and incarcerated in a juvenile facility. The measures consisted of self-reported acts of social aggression, simple and aggravated assault, subtypes of depression, and self-reports on parental care and control. Our data demonstrate the importance of including gender, types of aggression/assault, subtypes of depression, and familial factors when examining their association...
November 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29242833/put3-positively-regulates-proline-utilization-in-candida-albicans
#6
Walters Aji Tebung, Raha Parvizi Omran, Debra L Fulton, Joachim Morschhäuser, Malcolm Whiteway
The zinc cluster transcription factor Put3 was initially characterized in Saccharomyces cerevisiae as the transcriptional activator of PUT1 and PUT2, two genes acting early in the proline assimilation pathway. We have used phenotypic studies, transcription profiling, and chromatin immunoprecipitation with microarray technology (ChIP-chip) to establish that unlike S. cerevisiae, which only uses proline as a nitrogen source, Candida albicans can use proline as a nitrogen source, a carbon source, or a source of both nitrogen and carbon...
November 2017: MSphere
https://www.readbyqxmd.com/read/29198562/disease-burden-and-costs-from-excess-alcohol-consumption-obesity-and-viral-hepatitis-fourth-report-of-the-lancet-standing-commission-on-liver-disease-in-the-uk
#7
REVIEW
Roger Williams, Graeme Alexander, Iain Armstrong, Alastair Baker, Neeraj Bhala, Ginny Camps-Walsh, Matthew E Cramp, Simon de Lusignan, Natalie Day, Anil Dhawan, John Dillon, Colin Drummond, Jessica Dyson, Graham Foster, Ian Gilmore, Mark Hudson, Deirdre Kelly, Andrew Langford, Neil McDougall, Petra Meier, Kieran Moriarty, Philip Newsome, John O'Grady, Rachel Pryke, Liz Rolfe, Peter Rice, Harry Rutter, Nick Sheron, Alison Taylor, Jeremy Thompson, Douglas Thorburn, Julia Verne, John Wass, Andrew Yeoman
This report contains new and follow-up metric data relating to the eight main recommendations of the Lancet Standing Commission on Liver Disease in the UK, which aim to reduce the unacceptable harmful consequences of excess alcohol consumption, obesity, and viral hepatitis. For alcohol, we provide data on alcohol dependence, damage to families, and the documented increase in alcohol consumption since removal of the above-inflation alcohol duty escalator. Alcoholic liver disease will shortly overtake ischaemic heart disease with regard to years of working life lost...
November 28, 2017: Lancet
https://www.readbyqxmd.com/read/29185060/the-comptox-chemistry-dashboard-a-community-data-resource-for-environmental-chemistry
#8
Antony J Williams, Christopher M Grulke, Jeff Edwards, Andrew D McEachran, Kamel Mansouri, Nancy C Baker, Grace Patlewicz, Imran Shah, John F Wambaugh, Richard S Judson, Ann M Richard
Despite an abundance of online databases providing access to chemical data, there is increasing demand for high-quality, structure-curated, open data to meet the various needs of the environmental sciences and computational toxicology communities. The U.S. Environmental Protection Agency's (EPA) web-based CompTox Chemistry Dashboard is addressing these needs by integrating diverse types of relevant domain data through a cheminformatics layer, built upon a database of curated substances linked to chemical structures...
November 28, 2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29173760/targeting-dna-damage-in-sclc
#9
REVIEW
Victoria Foy, Maximilian W Schenk, Katie Baker, Fabio Gomes, Alice Lallo, Kristopher K Frese, Martin Forster, Caroline Dive, Fiona Blackhall
SCLC accounts for 15% of lung cancer worldwide. Characterised by early dissemination and rapid development of chemo-resistant disease, less than 5% of patients survive 5 years. Despite 3 decades of clinical trials there has been no change to the standard platinum and etoposide regimen for first line treatment developed in the 1970's. The exceptionally high number of genomic aberrations observed in SCLC combined with the characteristic rapid cellular proliferation results in accumulation of DNA damage and genomic instability...
December 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29135276/effects-of-the-new-york-state-concussion-management-and-awareness-act-lystedt-law-on-concussion-related-emergency-health-care-utilization-among-adolescents-2005-2015
#10
David R Baker, Erin R Kulick, Amelia K Boehme, James M Noble
BACKGROUND: All states have enacted legislation addressing the management of sports-related concussions (SRCs) in adolescent athletes. The effect of these laws on health care utilization is uncertain. Hypothesis/Purpose: The purpose was to evaluate the effects of New York's 2011 Concussion Management and Awareness Act ("Lystedt Law") on emergency department (ED) concussion health care visits (EDCHVs) and brain imaging utilization. It was hypothesized that New York concussion legislation would have a significant temporal effect on EDCHVs...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29066930/the-effect-of-pregabalin-or-duloxetine-on-arthritis-pain-a-clinical-and-mechanistic-study-in-people-with-hand-osteoarthritis
#11
Nidhi Sofat, Abiola Harrison, Mark D Russell, Salma Ayis, Patrick D Kiely, Emma H Baker, Thomas Richard Barrick, Franklyn A Howe
Osteoarthritis (OA) is the most prevalent arthritis worldwide and is characterized by chronic pain and impaired physical function. We hypothesized that heightened pain in hand OA could be reduced with duloxetine or pregabalin. In this prospective, randomized clinical study, we recruited 65 participants, aged 40-75 years, with a Numerical Rating Scale (NRS) for pain of at least 5. Participants were randomized to one of the following three groups: duloxetine, pregabalin, and placebo. The primary endpoint was the NRS pain score, and the secondary endpoints included the Australian and Canadian Hand Osteoarthritis Index (AUSCAN) pain, stiffness, and function scores and quantitative sensory testing by pain pressure algometry...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28973321/visual-search-behavior-in-individuals-with-retinitis-pigmentosa-during-level-walking-and-obstacle-crossing
#12
Matthew A Timmis, Jon Allsop, Mohammad Baranian, James Baker, Itay Basevitch, Keziah Latham, Shahina Pardhan, Kjell N van Paridon
Purpose: Investigate the visual search strategy of individuals with retinitis pigmentosa (RP) when negotiating a floor-based obstacle compared with level walking, and compared with those with normal vision. Methods: Wearing a mobile eye tracker, individuals with RP and normal vision walked along a level walkway or walked along the walkway negotiating a floor-based obstacle. In the level walking condition, tape was placed on the floor to act as an object attracting visual attention...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28972577/genome-wide-association-study-across-european-and-african-american-ancestries-identifies-a-snp-in-dnmt3b-contributing-to-nicotine-dependence
#13
D B Hancock, Y Guo, G W Reginsson, N C Gaddis, S M Lutz, R Sherva, A Loukola, C C Minica, C A Markunas, Y Han, K A Young, D F Gudbjartsson, F Gu, D W McNeil, B Qaiser, C Glasheen, S Olson, M T Landi, P A F Madden, L A Farrer, J Vink, N L Saccone, M C Neale, H R Kranzler, J McKay, R J Hung, C I Amos, M L Marazita, D I Boomsma, T B Baker, J Gelernter, J Kaprio, N E Caporaso, T E Thorgeirsson, J E Hokanson, L J Bierut, K Stefansson, E O Johnson
Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence variants in nicotine acetylcholine receptor genes and at other loci. To search for additional loci, we conducted a genome-wide association study (GWAS) meta-analysis of nicotine dependence, totaling 38,602 smokers (28,677 Europeans/European Americans and 9925 African Americans) across 15 studies...
October 3, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28971014/occurrence-of-tongue-worm-linguatula-cf-serrata-pentastomida-linguatulidae-in-wild-canids-and-livestock-in-south-eastern-australia
#14
Shokoofeh Shamsi, Kate McSpadden, Sara Baker, David J Jenkins
Pentastomids are obligate zoonotic arthropod parasites utilising canids and vulpids as their definitive hosts and several herbivorous species as their intermediate hosts. Reported only 10 times in Australia over the last 150 years as incidental findings, adult Pentastomids referred to as Linguatula serrata have been encountered in nasal cavities of domestic and wild dogs, and foxes. Nymphs have been reported in cattle and rabbits. In the present study, a number of potential definitive hosts, including red foxes (Vulpes vulpes), wild dogs (Canis lupus dingo and C...
December 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28965353/corticosterone-regulates-both-naturally-occurring-and-cocaine-induced-dopamine-signaling-by-selectively-decreasing-dopamine-uptake
#15
Daniel S Wheeler, Amanda L Ebben, Beliz Kurtoglu, Marissa E Lovell, Austin T Bohn, Isabella A Jasek, David A Baker, John R Mantsch, Paul J Gasser, Robert A Wheeler
Stressful and aversive events promote maladaptive reward-seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to produce a synergistic effect on reward circuitry. This effect is also observed when the stress hormone corticosterone is administered directly into the nucleus accumbens (NAc), indicating that glucocorticoids act locally in dopamine terminal regions to enhance cocaine's effects on dopamine signaling...
October 1, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28963853/the-effect-of-a-behavioral-activation-treatment-for-substance-use-on-post-treatment-abstinence-a-randomized-controlled-trial
#16
Stacey B Daughters, Jessica F Magidson, Deepika Anand, C J Seitz-Brown, Yun Chen, Sydney Baker
AIMS: To compare outcomes for a behavioral activation group treatment for substance use [life enhancement treatment for substance use (LETS ACT)] versus a time and group size-matched control condition delivered in a residential treatment setting. DESIGN: Single-site two-arm parallel-group randomized clinical trial with follow-up assessment at 3, 6 and 12 months post-treatment. SETTING: Residential substance use treatment facility in the United States...
March 2018: Addiction
https://www.readbyqxmd.com/read/28953069/e-scripts-and-cell-phones-a-blessing-or-curse
#17
Susie T Harris, Paul D Bell, Elizabeth A Baker
E-scripts have been used as part of computerized provider order entry implementation for several years now, particularly with the passage of the American Recovery and Reinvestment Act, Meaningful Use, the Health Information Portability and Accountability Act, the Health Information Technology for Economic and Clinical Health Act, and other laws and regulations. This case study seeks to focus on 2 specific aspects of the effect of increasing electronic technology within health care: e-prescriptions and cell phones or smartphones...
October 2017: Health Care Manager
https://www.readbyqxmd.com/read/28944233/protein-structure-and-phenotypic-analysis-of-pathogenic-and-population-missense-variants-in-stxbp1
#18
Mohnish Suri, Jochem M G Evers, Roman A Laskowski, Sinead O'Brien, Kate Baker, Jill Clayton-Smith, Tabib Dabir, Dragana Josifova, Shelagh Joss, Bronwyn Kerr, Alison Kraus, Meriel McEntagart, Jenny Morton, Audrey Smith, Miranda Splitt, Janet M Thornton, Caroline F Wright
BACKGROUND: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane. Studies have shown that pathogenic loss-of-function variants in this gene result in various types of epilepsies, mostly beginning early in life. We were interested to model pathogenic missense variants on the protein structure to investigate the mechanism of pathogenicity and genotype-phenotype correlations. METHODS: We report 11 patients with pathogenic de novo mutations in STXBP1 identified in the first 4293 trios of the Deciphering Developmental Disorder (DDD) study, including six missense variants...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28919436/the-notch-pathway-regulates-the-second-mitotic-wave-cell-cycle-independently-of-bhlh-proteins
#19
Abhishek Bhattacharya, Ke Li, Manon Quiquand, Gerard Rimesso, Nicholas E Baker
Notch regulates both neurogenesis and cell cycle activity to coordinate precursor cell generation in the differentiating Drosophila eye. Mosaic analysis with mitotic clones mutant for Notch components was used to identify the pathway of Notch signaling that regulates the cell cycle in the Second Mitotic Wave. Although S phase entry depends on Notch signaling and on the transcription factor Su(H), the transcriptional co-activator Mam and the bHLH repressor genes of the E(spl)-Complex were not essential, although these are Su(H) coactivators and targets during the regulation of neurogenesis...
November 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28916264/sidt2-transports-extracellular-dsrna-into-the-cytoplasm-for-innate-immune-recognition
#20
Tan A Nguyen, Blake R C Smith, Michelle D Tate, Gabrielle T Belz, Marilou H Barrios, Kirstin D Elgass, Alexandra S Weisman, Paul J Baker, Simon P Preston, Lachlan Whitehead, Alexandra Garnham, Rachel J Lundie, Gordon K Smyth, Marc Pellegrini, Meredith O'Keeffe, Ian P Wicks, Seth L Masters, Craig P Hunter, Ken C Pang
Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival...
September 19, 2017: Immunity
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