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https://www.readbyqxmd.com/read/29672327/the-affordable-care-act-decreased-the-proportion-of-uninsured-patients-in-a-safety-net-orthopaedic-clinic
#1
Joseph A Gil, Avi D Goodman, Justin Kleiner, Robin N Kamal, Laurence C Baker, Edward Akelman
BACKGROUND: The Patient Protection and Affordable Care Act (ACA) was approved in 2010, substantially altering the economics of providing and receiving healthcare services in the United States. One of the primary goals of this legislation was to expand insurance coverage for under- and uninsured residents. Our objective was to examine the effect of the ACA on the insurance status of patients at a safety net clinic. Our institution houses a safety net clinic that provides the dominant majority of orthopaedic care for uninsured patients in our state...
May 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29663355/microbial-decomposers-not-constrained-by-climate-history-along-a-mediterranean-climate-gradient-in-southern-california
#2
Nameer R Baker, Banafshe Khalili, Jennifer B H Martiny, Steven D Allison
Microbial decomposers mediate the return of CO2 to the atmosphere by producing extracellular enzymes to degrade complex plant polymers, making plant carbon available for metabolism. Determining if and how these decomposer communities are constrained in their ability to degrade plant litter is necessary for predicting how carbon cycling will be affected by future climate change. We analyzed mass loss, litter chemistry, microbial biomass, extracellular enzyme activities, and enzyme temperature sensitivities in grassland litter transplanted along a Mediterranean climate gradient in southern California...
April 17, 2018: Ecology
https://www.readbyqxmd.com/read/29656670/pain-and-hardship-among-older-men-examining-the-buffering-effect-of-medicare-insurance-coverage
#3
Gillian L Marshall, Tamara A Baker, Chiho Song, David B Miller
To better understand the health status of men in the United States, this study aimed to assess the association of hardship on the presence of and pain severity among men 50 years of age and older. Cross-sectional multivariate logistic regression analyses were conducted using the 2010 wave of the Health and Retirement Study ( N = 3,174) to assess the association between four hardship indicators and the presence of pain and pain severity among this sample of older men. Results suggest that the association between the presence of pain and hardship was statistically significant across all four indicators: ongoing financial hardship (CI [1...
April 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29607284/development-of-a-yeast-heterologous-expression-cassette-based-on-the-promoter-and-terminator-elements-of-the-eremothecium-cymbalariae-translational-elongation-factor-1%C3%AE-ectef1-gene
#4
Tomas Linder
A new expression cassette ( EC0 ) consisting of the fused 5' and 3' intergenic regions (IGRs) of the Eremothecium cymbalariae translational elongation factor 1α ( EcTEF1 ) gene was evaluated through expression of the bacterial hygromycin B phosphotransferase ( hph ) resistance gene in the common baker's yeast Saccharomyces cerevisiae . Progressively shorter versions of the hph -containing EC cassette ( hphEC1 though hphEC6 ) with trimmed 5' and 3' EcTEF1 IGRs were tested for their ability to confer resistance to hygromycin B in S...
April 2018: 3 Biotech
https://www.readbyqxmd.com/read/29576870/nivolumab-induced-fulminant-diabetic-ketoacidosis-followed-by-thyroiditis
#5
Ploutarchos Tzoulis, Richard W Corbett, Swarupini Ponnampalam, Elly Baker, Daniel Heaton, Triada Doulgeraki, Justin Stebbing
Five days following the 3rd cycle of nivolumab, a monoclonal antibody, which acts as immune checkpoint inhibitor against the programmed cell death protein-1, for metastatic lung adenocarcinoma, a 56-year-old woman presented at the hospital critically ill. On admission, she had severe diabetic ketoacidosis (DKA), as evidenced by venous glucose of 47 mmol/L, blood ketones of 7.5 mmol/L, pH of 6.95 and bicarbonate of 6.6 mmol/L. She has had no personal or family history of diabetes mellitus (DM), while random venous glucose, measured 1 week prior to hospitalisation, was 6...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29559638/the-human-cortex-possesses-a-reconfigurable-dynamic-network-architecture-that-is-disrupted-in-psychosis
#6
Jenna M Reinen, Oliver Y Chén, R Matthew Hutchison, B T Thomas Yeo, Kevin M Anderson, Mert R Sabuncu, Dost Öngür, Joshua L Roffman, Jordan W Smoller, Justin T Baker, Avram J Holmes
Higher-order cognition emerges through the flexible interactions of large-scale brain networks, an aspect of temporal coordination that may be impaired in psychosis. Here, we map the dynamic functional architecture of the cerebral cortex in healthy young adults, leveraging this atlas of transient network configurations (states), to identify state- and network-specific disruptions in patients with schizophrenia and psychotic bipolar disorder. We demonstrate that dynamic connectivity profiles are reliable within participants, and can act as a fingerprint, identifying specific individuals within a larger group...
March 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29554195/association-of-inhaled-corticosteroids-and-long-acting-%C3%AE-agonists-as-controller-and-quick-relief-therapy-with-exacerbations-and-symptom-control-in-persistent-asthma-a-systematic-review-and-meta-analysis
#7
Diana M Sobieraj, Erin R Weeda, Elaine Nguyen, Craig I Coleman, C Michael White, Stephen C Lazarus, Kathryn V Blake, Jason E Lang, William L Baker
Importance: Combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as the controller and the quick relief therapy termed single maintenance and reliever therapy (SMART) is a potential therapeutic regimen for the management of persistent asthma. Objective: To conduct a systematic review and meta-analysis of the effects of SMART in patients with persistent asthma. Data Sources and Study Selection: The databases of MEDLINE via OVID, EMBASE, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews were searched from database inception through August 2016 and updated through November 28, 2017...
March 19, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29554174/association-of-inhaled-corticosteroids-and-long-acting-muscarinic-antagonists-with-asthma-control-in-patients-with-uncontrolled-persistent-asthma-a-systematic-review-and-meta-analysis
#8
Diana M Sobieraj, William L Baker, Elaine Nguyen, Erin R Weeda, Craig I Coleman, C Michael White, Stephen C Lazarus, Kathryn V Blake, Jason E Lang
Importance: Long-acting muscarinic antagonists (LAMAs) are a potential adjunct therapy to inhaled corticosteroids in the management of persistent asthma. Objective: To conduct a systematic review and meta-analysis of the effects associated with LAMA vs placebo or vs other controllers as an add-on therapy to inhaled corticosteroids and the use of a LAMA as add-on therapy to inhaled corticosteroids and long-acting β-agonists (LABAs; hereafter referred to as triple therapy) vs inhaled corticosteroids and LABA in patients with uncontrolled, persistent asthma...
March 19, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29550884/cladribine-treatment-of-multiple-sclerosis-is-associated-with-depletion-of-memory-b-cells
#9
Bryan Ceronie, Benjamin M Jacobs, David Baker, Nicolas Dubuisson, Zhifeng Mao, Francesca Ammoscato, Helen Lock, Hilary J Longhurst, Gavin Giovannoni, Klaus Schmierer
BACKGROUND: The mechanism of action of oral cladribine, recently licensed for relapsing multiple sclerosis, is unknown. OBJECTIVE: To determine whether cladribine depletes memory B cells consistent with our recent hypothesis that effective, disease-modifying treatments act by physical/functional depletion of memory B cells. METHODS: A cross-sectional study examined 40 people with multiple sclerosis at the end of the first cycle of alemtuzumab or injectable cladribine...
March 17, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29549326/scalable-total-synthesis-and-comprehensive-structure-activity-relationship-studies-of-the-phytotoxin-coronatine
#10
Mairi M Littleson, Christopher M Baker, Anne J Dalençon, Elizabeth C Frye, Craig Jamieson, Alan R Kennedy, Kenneth B Ling, Matthew M McLachlan, Mark G Montgomery, Claire J Russell, Allan J B Watson
Natural phytotoxins are valuable starting points for agrochemical design. Acting as a jasmonate agonist, coronatine represents an attractive herbicidal lead with novel mode of action, and has been an important synthetic target for agrochemical development. However, both restricted access to quantities of coronatine and a lack of a suitably scalable and flexible synthetic approach to its constituent natural product components, coronafacic and coronamic acids, has frustrated development of this target. Here, we report gram-scale production of coronafacic acid that allows a comprehensive structure-activity relationship study of this target...
March 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29422840/mechanisms-underlying-serotonergic-excitation-of-callosal-projection-neurons-in-the-mouse-medial-prefrontal-cortex
#11
Emily K Stephens, Arielle L Baker, Allan T Gulledge
Serotonin (5-HT) selectively excites subpopulations of pyramidal neurons in the neocortex via activation of 5-HT2A (2A) receptors coupled to Gq subtype G-protein alpha subunits. Gq-mediated excitatory responses have been attributed primarily to suppression of potassium conductances, including those mediated by KV7 potassium channels (i.e., the M-current), or activation of non-specific cation conductances that underlie calcium-dependent afterdepolarizations (ADPs). However, 2A-dependent excitation of cortical neurons has not been extensively studied, and no consensus exists regarding the underlying ionic effector(s) involved...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29332144/long-acting-%C3%AE-2-agonists-in-asthma-enantioselective-safety-studies-are-needed
#12
Glenn A Jacobson, Sharanne Raidal, Morten Hostrup, Luigino Calzetta, Richard Wood-Baker, Mark O Farber, Clive P Page, E Haydn Walters
Long-acting β2-agonists (LABAs) such as formoterol and salmeterol are used for prolonged bronchodilatation in asthma, usually in combination with inhaled corticosteroids (ICSs). Unexplained paradoxical asthma exacerbations and deaths have been associated with LABAs, particularly when used without ICS. LABAs clearly demonstrate effective bronchodilatation and steroid-sparing activity, but long-term treatment can lead to tolerance of their bronchodilator effects. There are also concerns with regard to the effects of LABAs on bronchial hyperresponsiveness (BHR), where long-term use is associated with increased BHR and loss of bronchoprotection...
January 13, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29323635/mukb-atpases-are-regulated-independently-by-the-n-and-c-terminal-domains-of-mukf-kleisin
#13
Katarzyna Zawadzka, Pawel Zawadzki, Rachel Baker, Karthik V Rajasekar, Florence Wagner, David J Sherratt, Lidia K Arciszewska
The Escherichia coli SMC complex, MukBEF, acts in chromosome segregation. MukBEF shares the distinctive architecture of other SMC complexes, with one prominent difference; unlike other kleisins, MukF forms dimers through its N-terminal domain. We show that a 4-helix bundle adjacent to the MukF dimerisation domain interacts functionally with the MukB coiled-coiled 'neck' adjacent to the ATPase head. We propose that this interaction leads to an asymmetric tripartite complex, as in other SMC complexes. Since MukF dimerisation is preserved during this interaction, MukF directs the formation of dimer of dimer MukBEF complexes, observed previously in vivo...
January 11, 2018: ELife
https://www.readbyqxmd.com/read/29299555/a-m-18-l-6-metal-organic-nanocapsule-with-open-windows-using-mixed-macrocycles
#14
Chen Zhang, Kanishka Sikligar, Rahul S Patil, Charles L Barnes, Gary A Baker, Jerry L Atwood
We present here the preparation of a M18 L6 hexameric metal-organic nanocapsule using a pyrogallol[3]resorcin[1]arene mixed macrocycle. The introduction of resorcinol moieties within the assembly leads to the formation of two open windows. This study demonstrates that introducing defects into the existing structure of nanocapsules may act as an effective method to tailor the composition and geometry, and introduce new properties.
January 16, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29295011/the-association-among-parental-bonding-depression-social-aggression-and-criminal-assault-are-there-gender-differences-between-male-and-female-youth-offenders
#15
John Tisak, Marie S Tisak, Erin R Baker, Kelly E Amrhein, Cjersti Jensen
This research examined similarities and differences in gender regarding social aggression, criminal assault, depression, and familial factors. The participants were 251 youth offenders (158 males) who were arrested and incarcerated in a juvenile facility. The measures consisted of self-reported acts of social aggression, simple and aggravated assault, subtypes of depression, and self-reports on parental care and control. Our data demonstrate the importance of including gender, types of aggression/assault, subtypes of depression, and familial factors when examining their association...
November 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29242833/put3-positively-regulates-proline-utilization-in-candida-albicans
#16
Walters Aji Tebung, Raha Parvizi Omran, Debra L Fulton, Joachim Morschhäuser, Malcolm Whiteway
The zinc cluster transcription factor Put3 was initially characterized in Saccharomyces cerevisiae as the transcriptional activator of PUT1 and PUT2 , two genes acting early in the proline assimilation pathway. We have used phenotypic studies, transcription profiling, and chromatin immunoprecipitation with microarray technology (ChIP-chip) to establish that unlike S. cerevisiae , which only uses proline as a nitrogen source, Candida albicans can use proline as a nitrogen source, a carbon source, or a source of both nitrogen and carbon...
November 2017: MSphere
https://www.readbyqxmd.com/read/29198562/disease-burden-and-costs-from-excess-alcohol-consumption-obesity-and-viral-hepatitis-fourth-report-of-the-lancet-standing-commission-on-liver-disease-in-the-uk
#17
REVIEW
Roger Williams, Graeme Alexander, Iain Armstrong, Alastair Baker, Neeraj Bhala, Ginny Camps-Walsh, Matthew E Cramp, Simon de Lusignan, Natalie Day, Anil Dhawan, John Dillon, Colin Drummond, Jessica Dyson, Graham Foster, Ian Gilmore, Mark Hudson, Deirdre Kelly, Andrew Langford, Neil McDougall, Petra Meier, Kieran Moriarty, Philip Newsome, John O'Grady, Rachel Pryke, Liz Rolfe, Peter Rice, Harry Rutter, Nick Sheron, Alison Taylor, Jeremy Thompson, Douglas Thorburn, Julia Verne, John Wass, Andrew Yeoman
This report contains new and follow-up metric data relating to the eight main recommendations of the Lancet Standing Commission on Liver Disease in the UK, which aim to reduce the unacceptable harmful consequences of excess alcohol consumption, obesity, and viral hepatitis. For alcohol, we provide data on alcohol dependence, damage to families, and the documented increase in alcohol consumption since removal of the above-inflation alcohol duty escalator. Alcoholic liver disease will shortly overtake ischaemic heart disease with regard to years of working life lost...
November 29, 2017: Lancet
https://www.readbyqxmd.com/read/29185060/the-comptox-chemistry-dashboard-a-community-data-resource-for-environmental-chemistry
#18
Antony J Williams, Christopher M Grulke, Jeff Edwards, Andrew D McEachran, Kamel Mansouri, Nancy C Baker, Grace Patlewicz, Imran Shah, John F Wambaugh, Richard S Judson, Ann M Richard
Despite an abundance of online databases providing access to chemical data, there is increasing demand for high-quality, structure-curated, open data to meet the various needs of the environmental sciences and computational toxicology communities. The U.S. Environmental Protection Agency's (EPA) web-based CompTox Chemistry Dashboard is addressing these needs by integrating diverse types of relevant domain data through a cheminformatics layer, built upon a database of curated substances linked to chemical structures...
November 28, 2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29173760/targeting-dna-damage-in-sclc
#19
REVIEW
Victoria Foy, Maximilian W Schenk, Katie Baker, Fabio Gomes, Alice Lallo, Kristopher K Frese, Martin Forster, Caroline Dive, Fiona Blackhall
SCLC accounts for 15% of lung cancer worldwide. Characterised by early dissemination and rapid development of chemo-resistant disease, less than 5% of patients survive 5 years. Despite 3 decades of clinical trials there has been no change to the standard platinum and etoposide regimen for first line treatment developed in the 1970's. The exceptionally high number of genomic aberrations observed in SCLC combined with the characteristic rapid cellular proliferation results in accumulation of DNA damage and genomic instability...
December 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29135276/effects-of-the-new-york-state-concussion-management-and-awareness-act-lystedt-law-on-concussion-related-emergency-health-care-utilization-among-adolescents-2005-2015
#20
David R Baker, Erin R Kulick, Amelia K Boehme, James M Noble
BACKGROUND: All states have enacted legislation addressing the management of sports-related concussions (SRCs) in adolescent athletes. The effect of these laws on health care utilization is uncertain. Hypothesis/Purpose: The purpose was to evaluate the effects of New York's 2011 Concussion Management and Awareness Act ("Lystedt Law") on emergency department (ED) concussion health care visits (EDCHVs) and brain imaging utilization. It was hypothesized that New York concussion legislation would have a significant temporal effect on EDCHVs...
November 1, 2017: American Journal of Sports Medicine
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