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https://www.readbyqxmd.com/read/29784435/pulmonary-renal-syndrome-secondary-to-cocaine-levamisole-induced-vasculitis-a-case-report
#1
Mauricio Restrepo-Escobar, Dayana Sylva, Juan Guillermo Gamboa, Andrés Echeverri, Javier Márquez, Luis Fernando Pinto
Pulmonary-renal syndrome has rarely been reported as the clinical presentation of vasculitis caused by the consumption of cocaine adulterated with levamisole. We report the case of a patient in whom we detected the clinical manifestations and indicate the difficulties that arose in relation to the diagnostic and therapeutic approach.
May 18, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29784374/polymer-platforms-for-selective-detection-of-cocaine-in-street-samples-adulterated-with-levamisole
#2
Anca Florea, Todd Cowen, Sergey Piletsky, Karolien De Wael
Accurate drug detection is of utmost importance for fighting against drug abuse. With a high number of cutting agents and adulterants being added to cut or mask drugs in street powders the number of false results is increasing. We demonstrate for the first time the usefulness of employing polymers readily synthesized by electrodeposition to selectively detect cocaine in the presence of the commonly used adulterant levamisole. The polymers were selected by computational modelling to exhibit high binding affinity towards cocaine and deposited directly on the surface of graphene-modified electrodes via electropolymerization...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29782427/clinical-profile-of-levamisole-adulterated-cocaine-induced-vasculitis-vasculopathy-a-30-case-series
#3
Carlos Horacio Muñoz-Vahos, Sebastián Herrera-Uribe, Álvaro Arbeláez-Cortés, Daniel Jaramillo-Arroyave, Luis Alonso González-Naranjo, Gloria Vásquez-Duque, Mauricio Restrepo-Escobar, Luis Alfonso Correa-Londoño, Luis Fernando Arias-Restrepo, Adriana Lucía Vanegas-García
OBJECTIVES: The aims of this study were to describe clinical and laboratory manifestations of patients with levamisole-adulterated cocaine-induced vasculitis/vasculopathy and to propose a skin classification according to the distribution and severity of lesions. METHODS: We report the characteristics of 30 patients admitted with levamisole-adulterated cocaine-induced vasculitis/vasculopathy in 4 high-complexity institutions in Colombia, from December 2010 to May 2017...
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29719008/deciphering-the-molecular-determinants-of-cholinergic-anthelmintic-sensitivity-in-nematodes-when-novel-functional-validation-approaches-highlight-major-differences-between-the-model-caenorhabditis-elegans-and-parasitic-species
#4
Alexandra Blanchard, Fabrice Guégnard, Claude L Charvet, Anna Crisford, Elise Courtot, Christine Sauvé, Abdallah Harmache, Thomas Duguet, Vincent O'Connor, Philippe Castagnone-Sereno, Barbara Reaves, Adrian J Wolstenholme, Robin N Beech, Lindy Holden-Dye, Cedric Neveu
Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic paralysis by activating acetylcholine receptors (AChRs) expressed in nematode body wall muscles. In the model nematode Caenorhabditis elegans, genetic screens led to the identification of five genes encoding levamisole-sensitive-AChR (L-AChR) subunits: unc-38, unc-63, unc-29, lev-1 and lev-8. These subunits form a functional L-AChR when heterologously expressed in Xenopus laevis oocytes...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29716880/report-an-ex-vivo-up-take-of-levamisole-molecules-by-cestode-monezia-expensa-of-goat-capra-hirsa-and-its-detection-through-rp-hplc
#5
Muhammad Mazhar Ayaz, Muhammad Sajid, Sanjota Nirmal Das, Muhammad Hanif
Detection of various molecules of drugs remained a prime issue especially in tissues of animals, humans and in their target parasites. The cestode/tapeworms pose a dilemma because of their weird body composition and uptake pattern of nutrients and medicines especially through absorption by tegument. We selected levamisole; thought to be potent antiparasitic/ani-cestodal drug. The uptake of levamisole (LEV) through cestodeal tissues is studied through HPCL in this paper. High performance liquid chromatography technique has been utilized to know the uptake of levamisole in tissues of cestodes of Goat (Monezia expensa) in small ruminants...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29692928/a-novel-application-of-an-anthelmintic-mixture-for-use-against-gastrointestinal-parasites-of-red-deer-cervus-elaphus
#6
P L Hughes
A mixture of proprietary anthelmintics delivering 0.5 mg/kg moxidectin, 9.06 mg/kg oxfendazole, 15 mg/kg levamisole, and 0.08 mg/kg selenium on bodyweight basis per os to red deer is investigated. On a deer farm with a history of parasite problems, six weaner red deer were treated orally with a 50/50 mixture of Exodus Pour-On and Oxfen C Plus (Ex/Ox) at a dose rate of 1 ml/5 kg bodyweight. Six herd mates were untreated. Eleven days later abomasal worm counts for the untreated deer revealed an arithmetic mean burden of 2,566 Ostertagia -type worms and 300 Trichostrongylus axei ...
2018: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29657412/effect-of-levamisole-vitamin-e-and-selenium-against-aflatoxicosis-in-broilers-chicken
#7
Amjed H Ulaiwi
Aim: The experiment was conducted to determine of levamisole (0.2 ml/kg-BW), Vitamin E (80 mg)+selenium (1.6 mg), and aflatoxin (B1) (positive control) compared with group without aflatoxin (negative control) on some liver enzymes (aspartate transaminase [AST] and alanine transaminase [ALT]), as well as to study the histopathological changes. Materials and Methods: The experiment included (200) 1-day-old broilers Ross 308 (Turkey source) mixed sexes. They were divided into four equal groups (50 chicks each group)...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29607229/a-case-of-levamisole-induced-agranulocytosis
#8
Thamer Kassim, Lakshmi Chintalacheruvu, Osman Bhatty, Mohammad Selim, Osama Diab, Ali Nayfeh, Jayadev Manikkam Umakanthan, Maryam Gbadamosi-Akindele
A sixty-eight-year-old male with a past medical history of recurrent cocaine use presented to the emergency department with recurrent diarrhea and was found to have a white blood cell (WBC) count of 1.9 × 109 /L with agranulocytosis (absolute neutrophil count (ANC) of 95 cell/mm3 ). At admission, the patient disclosed that he used cocaine earlier during the day, and a urine drug screen tested positive for this. On hospital day one, the patient was found to have a fever with a maximum temperature of 313...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29536266/identification-and-quantification-of-cocaine-and-active-adulterants-in-coca-paste-seized-samples-useful-scientific-support-to-health-care
#9
Juan Andrés Abin-Carriquiry, Marcela Martínez-Busi, Martín Galvalisi, Manuel Minteguiaga, José Pedro Prieto, María Cecilia Scorza
Adulteration is a common practice in the illicit drugs market, but the psychoactive and toxic effects provided by adulterants are clinically underestimated. Coca-paste (CP) is a smokable form of cocaine which has an extremely high abuse liability. CP seized samples are sold adulterated; however, qualitative and quantitative data of CP adulteration in forensic literature is still scarce. Besides, it is unknown if adulterants remain stable when CP is heated. This study was designed to report the chemical content of an extensive series of CP seized samples and to demonstrate the stability (i...
March 13, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29520317/levamisole-induced-vasculitis
#10
Lohrasb Sayadi, Donald Laub
No abstract text is available yet for this article.
2018: Eplasty
https://www.readbyqxmd.com/read/29518401/effect-of-the-dispersion-states-of-azone-in-hydroalcoholic-gels-on-its-transdermal-permeation-enhancement-efficacy
#11
Hui-Lin Chen, Chen-Chen Cai, Jun-Yuan Ma, Mei-Ling Yu, Mei-Hui Zhao, Jian-Bo Guo, Hui Xu
The objective of this study was to investigate the effect of dispersion states of azone in gels on the transdermal permeation of levamisole hydrochloride (LH). LH hydroalcoholic gels containing azone of different dispersion states were prepared by varying the contents of azone and Tween 80, and the in vitro transdermal permeation of LH across excised rat skin was evaluated. Depending on the content of azone, mixed solvents, and solubilizer used, azone presented as dissolved molecules, solubilized in micelles, and fine or coarse emulsion droplets in gels...
March 5, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29497999/supplementation-of-cr-methionine-during-dry-period-of-dairy-cows-and-its-effect-on-some-production-and-biochemical-parameters-during-early-lactation-and-on-immunity-of-their-offspring
#12
Eyup Eren Gultepe, Cangir Uyarlar, İsmail Bayram
This study aimed to investigate the effect of dietary chromium methionine (Cr-Met) supplementation on the production and immunological parameters of dairy cows during the dry and postpartum period and their offspring. Forty-five Holstein transition cows were randomly assigned to experimental groups with control, positive control (levamisole-injected cows), and treatment groups (5 g dietary Cr-Met/day/cow). Production, immunological, and biochemical parameters were analyzed during the dry and postpartum period...
March 1, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29496965/tropomyosin-isoforms-differentially-affect-muscle-contractility-in-the-head-and-body-regions-of-the-nematode-caenorhabditis-elegans
#13
Dawn E Barnes, Eichi Watabe, Kanako Ono, Euiyoung Kwak, Hidehito Kuroyanagi, Shoichiro Ono
Tropomyosin, one of the major actin filament-binding proteins, regulates actin-myosin interaction and actin-filament stability. Multicellular organisms express a number of tropomyosin isoforms, but understanding of isoform-specific tropomyosin functions is incomplete. The nematode Caenorhabditis elegans has a single tropomyosin gene, lev-11, which has been reported to express four isoforms by using two separate promoters and alternative splicing. Here, we report a fifth tropomyosin isoform, LEV-11O, which is produced by alternative splicing that includes a newly identified seventh exon, exon 7a...
May 1, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29473411/levamisole-a-common-adulterant-in-cocaine-street-samples-hindering-electrochemical-detection-of-cocaine
#14
Mats de Jong, Anca Florea, Anne-Mare de Vries, Alexander L N van Nuijs, Adrian Covaci, Filip Van Durme, José C Martins, Nele Samyn, Karolien De Wael
The present work investigates the electrochemical determination of cocaine in the presence of levamisole, one of the most common adulterants found in cocaine street samples. Levamisole misleads cocaine color tests, giving a blue color (positive test) even in the absence of cocaine. Moreover, the electrochemical detection of cocaine is also affected by the presence of levamisole, with a suppression of the oxidation signal of cocaine. When levamisole is present in the sample in ratios higher than 1:1, the cocaine signal is no longer detected, thus leading to false negative results...
April 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29469750/a-case-of-probable-trimethoprim-sulfamethoxazole-induced-circulating-antineutrophil-cytoplasmic-antibody-positive-small-vessel-vasculitis
#15
Therese Woodring, Ronnie Abraham, Stephanie Frisch
Cutaneous leukocytoclastic vasculitis (LCV) can occur as skin-limited disease or as part a systemic vasculitis. Appropriate workup includes the evaluation of antineutrophil cytoplasmic antibodies (ANCAs), with a positive titer raising concern for the associated primary vasculitides including microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), or eosinophilic granulomatosis with polyangiitis (EGPA). In the absence of systemic findings, however, a drug etiology must also be considered. Tumor necrosis factor (TNF) inhibitors, propylthiouracil, levamisole-adulterated cocaine, hydralazine, and minocycline have been previously documented to induce ANCA-positive vasculitis (APV), which may present with conspicuously high ANCA titers...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468054/in-vitro-activity-of-ivermectin-against-staphylococcus-aureus-clinical-isolates
#16
Shoaib Ashraf, Umer Chaudhry, Ali Raza, Debasri Ghosh, Xin Zhao
Background: Ivermectin is an endectocide against many parasites. Though being a macrocyclic lactone, its activity against bacteria has been less known, possibly due to the fact that micromolar concentrations at tissue levels are required to achieve a therapeutic effect. Among pathogenic bacteria of major medical significance, Staphylococcus aureus cause a number of diseases in a wide variety of hosts including humans and animals. It has been attributed as one of the most pathogenic organisms...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29454838/analysis-of-cocaine-adulterants-in-human-brain-in-cases-of-drug-related-death
#17
Marianne Knuth, Oliver Temme, Thomas Daldrup, Evelyn Pawlik
For different reasons, street cocaine is often diluted with pharmacologically active substances, the so-called adulterants such as levamisole or hydroxyzine. A controversial debate exists currently on the uptake of adulterants from cocaine preparations and drug-related death. Previous research convincingly argues that serious adverse side effects that affect the central nervous and cardiovascular systems can be a consequence of adulterated cocaine. AIMS: Having identified the presence of adulterants in lung tissue and blood, the concentrations of these substances in brain, an important target location, was of interest...
April 2018: Forensic Science International
https://www.readbyqxmd.com/read/29426477/the-effect-on-liveweight-gain-of-using-anthelmintics-with-incomplete-efficacy-against-resistant-cooperia-oncophora-in-cattle
#18
Paul M Candy, Tania S Waghorn, Chris M Miller, Siva Ganesh, Dave M Leathwick
A replicated field trial was conducted to measure the effect on liveweight gain of failing to adequately control anthelmintic resistant populations of Cooperia oncophora and to determine whether populations, and hence production losses, increased with time. Eight mobs of 10 Friesian-Hereford calves were run on independent farmlets from January to December, over each of two years. All mobs were routinely treated with a pour-on formulation of eprinomectin every six weeks, which controlled parasites other than Cooperia...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29423942/erythema-elevatum-diutinum-like-vasculitis-secondary-to-cocaine-adulterated-with-levamisole
#19
A K Dewan, J Pinard, S Jadeja, S Granter, J F Merola
No abstract text is available yet for this article.
February 9, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29414003/wavenumber-selection-method-to-determine-the-concentration-of-cocaine-and-adulterants-in-cocaine-samples
#20
A Kahmann, M J Anzanello, F S Fogliatto, M C A Marcelo, M F Ferrão, R S Ortiz, K C Mariotti
Street cocaine is typically altered with several compounds that increase its harmful health-related side effects, most notably depression, convulsions, and severe damages to the cardiovascular system, lungs, and brain. Thus, determining the concentration of cocaine and adulterants in seized drug samples is important from both health and forensic perspectives. Although FTIR has been widely used to identify the fingerprint and concentration of chemical compounds, spectroscopy datasets are usually comprised of thousands of highly correlated wavenumbers which, when used as predictors in regression models, tend to undermine the predictive performance of multivariate techniques...
April 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
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