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https://www.readbyqxmd.com/read/29050222/beneficial-effect-of-fluoxetine-treatment-aganist-psychological-stress-is-mediated-by-increasing-bdnf-expression-in-selected-brain-areas
#1
Gongying Li, Ping Jing, Zhidong Liu, Zhiruo Li, Hongxia Ma, Wenzhen Tu, Wei Zhang, Chuanjun Zhuo
SSRI antidepressant fluoxetine is widely used to treat psychological stress related disorders, however the underlying working mechanisms is not fully understood, as SSRIs can rapidly increase the extracellular serotonin levels but it normally takes weeks to reveal their therapeutic effect in the stress-related psychological disorders. Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049732/iron-chelating-drugs-enhance-cone-photoreceptor-survival-in-a-mouse-model-of-retinitis-pigmentosa
#2
Ke Wang, Bo Peng, Jia Xiao, Orly Weinreb, Moussa B H Youdim, Bin Lin
Purpose: Retinitis pigmentosa (RP) is a group of hereditary retinal degeneration in which mutations commonly result in the initial phase of rod cell death followed by gradual cone cell death. The mechanisms by which the mutations lead to photoreceptor cell death in RP have not been clearly elucidated. There is currently no effective treatment for RP. The purpose of this work was to explore iron chelation therapy for improving cone survival and function in the rd10 mouse model of RP. Methods: Two iron-chelating drugs, 5-(4-(2-hydroxyethyl) piperazin-1-yl (methyl)-8-hydroxyquinoline (VK28) and its chimeric derivative 5-(N-methyl-N-propargyaminomethyl)-quinoline-8-oldihydrochloride (VAR10303), were injected intraperitoneally to rd10 mice every other day starting from postnatal day 14...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29046811/association-between-supervisors-behavior-and-wage-workers-job-stress-in-korea-analysis-of-the-fourth-korean-working-conditions-survey
#3
Shin Uk Kang, Byeong Jin Ye, ByoungGwon Kim, Jung Il Kim, Jung Woo Kim
BACKGROUND: In modern society, many workers are stressed. Supervisors' support or behavior can affect the emotional or psychological part of the worker. The purpose of this study is to investigate the effect of supervisor's behavior on worker's stress. METHODS: The study included 19,272 subjects following the assignment of weighted values to workers other than soldiers using data from the Fourth Korean Working Condition Survey. Supervisors' behavior was measured using 5 items: "supervisor feedback regarding work," "respectful attitude," "good conflict-resolution ability," "good work-related planning and organizational ability," and the encouragement of participation in important decision making...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29046678/kunitz-proteinase-inhibitors-limit-water-stress-responses-in-white-clover-trifolium-repens-l-plants
#4
Afsana Islam, Susanna Leung, Aluh Nikmatullah, Paul P Dijkwel, Michael T McManus
The response of plants to water deficiency or drought is a complex process, the perception of which is triggered at the molecular level before any visible morphological responses are detected. It was found that different groups of plant proteinase inhibitors (PIs) are induced and play an active role during abiotic stress conditions such as drought. Our previous work with the white clover (Trifolium repens L.) Kunitz Proteinase Inhibitor (Tr-KPI) gene family showed that Tr-KPIs are differentially regulated to ontogenetic and biotic stress associated cues and that, at least some members of this gene family may be required to maintain cellular homeostasis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29043281/predictors-of-post-traumatic-stress-disorder-among-victims-of-serious-motor-vehicle-accidents
#5
Naema Khodadadi-Hassankiadeh, Nahid Dehghan Nayeri, Hooman Shahsavari, Shahrokh Yousefzadeh-Chabok, Hamid Haghani
BACKGROUND: Compelling evidence has shown that motor vehicle accidents have an enormous impact on mental health. Post-traumatic Stress Disorder (PTSD) is one of the most common psychological consequences in adult survivors of accidents, so it is important to understand the prevalence and predictors of this issue since delay causes damage to crucial daily functioning. This study aimed at investigating the prevalence and predictors of PTSD after motor vehicle accident. METHODS: This cross-sectional study was conducted on 528 injured patients six weeks to six months after motor vehicle accident in Imam Reza Clinic of Poursina hospital, Rasht in 2015...
October 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29042826/clinical-reasoning-and-knowledge-management-in-final-year-medical-students-the-role-of-student-led-grand-rounds
#6
David Arumaisingam Kandiah
OBJECTIVES: The development of clinical reasoning and decision-making skills is often limited in medical school curricula. In reality, medical graduates acquire these skills during their first few years of residency. For many, this can be stressful as they may be working under limited supervision as a part of their rotations. METHODS: Student-led Grand Rounds was developed to transfer both explicit and tacit knowledge to final year medical students. This pilot project was to apply the principles of knowledge management to allow students to be exposed to the reasoning and decision making of common clinical presentations...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29042485/maternal-stress-during-pregnancy-and-allergic-diseases-in-children-during-the-first-year-of-life
#7
Katarzyna Smejda, Kinga Polanska, Dorota Merecz-Kot, Anna Krol, Wojciech Hanke, Joanna Jerzynska, Wlodzimierz Stelmach, Paweł Majak, Iwona Stelmach
BACKGROUND: Many recent studies indicate that prenatal maternal distress increases the risk of allergic diseases in children. The mechanisms that favor it are still unclear. OBJECTIVES: We aimed to assess the association between exposure to different kinds of prenatal stress and the occurrence of atopic dermatitis, food allergy, wheezing, and recurrent respiratory tract infections in children. METHODS: The study population consisted of 370 mother-child pairs from a Polish Mother and Child Cohort (REPRO_PL)...
October 17, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29042311/rational-design-of-botulinum-toxin-a1-mutants-with-improved-oxidative-stability
#8
Manuela López de la Paz, Daniel Scheps, Marcel Jurk, Fred Hofmann, Jürgen Frevert
Botulinum neurotoxins (BoNTs) are the most potent toxic proteins to mankind known but applied in low doses trigger a localized muscle paralysis that is beneficial for the therapy of several neurological disorders and aesthetic treatment. The paralytic effect is generated by the enzymatic activity of the light chain (LC) that cleaves specifically one of the SNARE proteins responsible for neurotransmitter exocytosis. The activity of the LC in a BoNT-containing therapeutic can be compromised by denaturing agents present during manufacturing and/or in the cell...
October 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29041862/impact-of-chronic-maternal-stress-during-early-gestation-on-maternal-fetal-stress-transfer-and-fetal-stress-sensitivity-in-sheep
#9
Michelle Dreiling, Rene Schiffner, Sabine Bischoff, Sven Rupprecht, Nasim Kroegel, Harald Schubert, Otto W Witte, Matthias Schwab, Florian Rakers
Acute stress-induced reduction of uterine blood flow (UBF) is an indirect mechanism of maternal-fetal stress transfer during late gestation. Effects of chronic psychosocial maternal stress (CMS) during early gestation, as may be experienced by many working women, on this stress signaling mechanism are unclear. We hypothesized that CMS in sheep during early gestation augments later acute stress-induced decreases of UBF, and aggravates the fetal hormonal, cardiovascular, and metabolic stress responses during later development...
October 18, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29039199/dielectric-breakdown-in-chemical-vapor-deposited-hexagonal-boron-nitride
#10
Lanlan Jiang, Yuanyuan Shi, Fei Hui, Kechao Tang, Qian Wu, Chengbin Pan, Xu Jing, Hasan J Uppal, Felix Roberto Mario Palumbo, Guangyuan Lu, Tianru Wu, Haomin Wang, Marco A Villena, Xiaoming Xie, Paul C McIntyre, Mario Lanza
Insulating films are essential in multiple electronic devices because they can provide essential functionalities, such as capacitance effects and electrical fields. Two dimensional (2D) layered materials have superb electronic, physical, chemical, thermal and optical properties, and they can be effectively used to provide additional performances (flexibility, transparency). 2D layered insulators are called to be essential in future electronic devices, but their reliability, degradation kinetics and dielectric breakdown process are still not understood...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29038682/depression-as-a-moderator-of-stair-narrative-therapy-for-women-with-post-traumatic-stress-disorder-related-to-childhood-abuse
#11
Marylene Cloitre, Donn W Garvert, Brandon J Weiss
Background: Depression among those who have experienced childhood abuse is associated with earlier onset, more persistent and severe symptoms, more frequent relapse, and poorer treatment outcomes across a variety of psychiatric disorders. In addition, individuals with a history of childhood abuse are more likely to develop post-traumatic stress disorder (PTSD) co-occurring with depression. Objective: This study evaluated whether severity of depression moderated the outcome in a PTSD treatment for childhood abuse survivors...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29038251/stress-introduction-rate-alters-benefit-of-acrab-tolc-efflux-pumps
#12
Ariel M Langevin, Mary J Dunlop
Stress tolerance studies are typically conducted in an all-or-none fashion. However, in realistic settings-such as in clinical or metabolic engineering applications-cells may encounter stresses at different rates. As such, how cells tolerate stress may depend on its rate of appearance. To address this, we study how the rate of introduction affects bacterial stress tolerance by focusing on a key mechanism for stress response. Efflux pumps, such as AcrAB-TolC from Escherichia coli, are membrane transporters well known for their ability to export a wide variety of substrates, including antibiotics, signaling molecules, and biofuels...
October 16, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/29037438/tag-team-roles-of-mirnas-and-proteolytic-regulators-in-ensuring-robust-gene-expression-dynamics
#13
REVIEW
Benjamin P Weaver, Min Han
Lack of prominent developmental defects arising from loss of many individual miRNAs is consistent with the observations of collaborative networks between miRNAs and roles for miRNAs in regulating stress responses. However, these characteristics may only partially explain the seemingly nonessential nature of many miRNAs. Non-miRNA gene expression regulatory mechanisms also collaborate with miRNA-induced silencing complex (miRISC) to support robust gene expression dynamics. Genetic enhancer screens have revealed roles of miRNAs and other gene repressive mechanisms in development or other cellular processes that were masked by genetic redundancy...
October 13, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29037399/comparison-of-heat-strain-recovery-in-different-anti-heat-stress-clothing-ensembles-after-work-to-exhaustion
#14
Yijie Zhao, Wen Yi, Albert P C Chan, Daniel W M Chan
A hot environment combined with physically demanding tasks can subject workers to a higher risk of heat stress. A series of regulations and guidelines have been proposed to design appropriate anti-heat stress work uniform to reduce body heat strain. The present study aimed to examine heat strain recovery in different anti-heat stress clothing ensembles after work to exhaustion in the heat. 10 healthy males performed intermittent treadmill running/walking to exhaustion, followed by 30min passive recovery sitting in a climatic chamber, which simulated the hot and humid outdoor environment (34°C temperature, 60% relative humidity, 0...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29036873/fighting-against-a-shortage-of-truck-drivers-in-logistics-measures-that-employers-can-take-to-promote-drivers-work-ability-and-health
#15
Ulrike Staats, Daniela Lohaus, Alina Christmann, Michèle Woitschek
BACKGROUND: For several years, the transportation industry has been concerned about a severe shortage of professional truck drivers. Studies investigating the reasons found that poor working conditions and stresses and strains resulting from physiological and psychological job demands have had a negative impact on drivers' health and ability to work. Nevertheless, until now, most employers have refrained from offering measures to support the work ability and well-being of drivers, mainly due to financial pressures in the industry...
October 10, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036663/metabolomic-and-biochemical-approaches-link-salicylic-acid-biosynthesis-to-cyanogenesis-in-peach-plants
#16
Pedro Diaz-Vivancos, Agustina Bernal-Vicente, Daniel Cantabella, Cesar Petri, José Antonio Hernández
Despite the long-established importance of salicylic acid (SA) in plant stress responses and other biological processes, its biosynthetic pathways have not been fully characterized. The proposed SA synthesis originates from chorismate by two distinct pathways: isochorismate and phenylalanine (Phe) ammonia-lyase (PAL) pathways. Cyanogenesis is the process related to the release of hydrogen cyanide from endogenous cyanogenic glycosides (CNglcs), and it has been linked to plant plasticity improvement. To date, however, no relationship has been suggested between both pathways...
September 25, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29035767/life-cycle-energy-impacts-for-adapting-an-urban-water-supply-system-to-droughts
#17
Ka Leung Lam, Jennifer R Stokes-Draut, Arpad Horvath, Joe L Lane, Steven J Kenway, Paul A Lant
In recent years, cities in some water stressed regions have explored alternative water sources such as seawater desalination and potable water recycling in spite of concerns over increasing energy consumption. In this study, we evaluate the current and future life-cycle energy impacts of four alternative water supply strategies introduced during a decade-long drought in South East Queensland (SEQ), Australia. These strategies were: seawater desalination, indirect potable water recycling, network integration, and rainwater tanks...
October 9, 2017: Water Research
https://www.readbyqxmd.com/read/29034854/whole-genome-transcriptomics-reveals-global-effects-including-up-regulation-of-francisella-pathogenicity-island-gene-expression-during-active-stringent-response-in-the-highly-virulent-francisella-tularensis-subsp-tularensis-schu-s4
#18
Amber L Murch, Paul J Skipp, Peter L Roach, Petra C F Oyston
During conditions of nutrient limitation bacteria undergo a series of global gene expression changes to survive conditions of amino acid and fatty acid starvation. Rapid reallocation of cellular resources is brought about by gene expression changes coordinated by the signalling nucleotides' guanosine tetraphosphate or pentaphosphate, collectively termed (p)ppGpp and is known as the stringent response. The stringent response has been implicated in bacterial virulence, with elevated (p)ppGpp levels being associated with increased virulence gene expression...
October 16, 2017: Microbiology
https://www.readbyqxmd.com/read/29034757/nano-alterations-of-membrane-structure-on-both-%C3%AE-irradiated-and-stored-human-erythrocytes
#19
M A Acosta-Elías, A J Burgara-Estrella, J A Sarabia-Sainz, E Silva-Campa, A Angulo-Molina, K J Santacruz-Gómez, B Castaneda, D Soto-Puebla, A I Ledesma-Osuna, R Melendrez-Amavizca, M Pedroza-Montero
PURPOSE: Storage and ionizing radiation of human red blood cells (RBC) produce alterations on RBC membranes and modify their normal shape and functionality. We investigated early morphological and biochemical changes in RBC due to those stressing agents at the nanoscale level and their impact on blood quality. MATERIALS AND METHODS: Whole blood samples from healthy donors were γ-irradiated with 15, 25, 35 and 50 Gy. Non-irradiated and non-stored RBC were used as control samples...
October 16, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29033997/the-effects-of-cognitive-behavioral-stress-management-on-nurses-job-stress
#20
Jafar Shariatkhah, Zahra Farajzadeh, Kolsoom Khazaee
BACKGROUND: Job stress is a prevalent and costly problem in different working conditions. Stress can degrade care quality in nurses and elevate their willingness to leave the job. This study aimed to determine the effects of cognitive-behavioral stress management on nurses' job stress. MATERIALS AND METHODS: In this quasi-experimental study with a control group, 40 nurses from the educational hospitals in Birjand who had completed a job stress questionnaire with a score of more than 100 were selected and randomly allocated to two groups...
September 2017: Iranian Journal of Nursing and Midwifery Research
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