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https://www.readbyqxmd.com/read/29678953/metabolic-adjustment-to-high-altitude-hypoxia-from-genetic-signals-to-physiological-implications
#1
REVIEW
Andrew J Murray, Hugh E Montgomery, Martin Feelisch, Michael P W Grocott, Daniel S Martin
Ascent to high altitude is associated with physiological responses that counter the stress of hypobaric hypoxia by increasing oxygen delivery and by altering tissue oxygen utilisation via metabolic modulation. At the cellular level, the transcriptional response to hypoxia is mediated by the hypoxia-inducible factor (HIF) pathway and results in promotion of glycolytic capacity and suppression of oxidative metabolism. In Tibetan highlanders, gene variants encoding components of the HIF pathway have undergone selection and are associated with adaptive phenotypic changes, including suppression of erythropoiesis and increased blood lactate levels...
April 20, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29678745/neurobehavioral-and-biochemical-modulation-following-administration-of-mgo-and-zno-nanoparticles-in-the-presence-and-absence-of-acute-stress
#2
Mozhgan Torabi, Mahnaz Kesmati, Nahid Pourreza, Hossein Najafzadeh Varzi, Hamid Galehdari
In this work, the effects of MgO and ZnO nanoparticles were investigated on some behavioral, hormonal and biochemical changes following acute stress. Wistar male rats were divided into groups of control, different times of restraint stress (90, 180 and 360 min), nano-MgO or nano-ZnO alone and with acute restraint stress. Anxiety-like behaviors and pain perception were evaluated by elevated plus maze and hot plate apparatus respectively. Levels of corticosterone hormone, malondialdehyde (MDA) and catalase activity, Mg, Zn, Fe and Ca were evaluated in the serum and hippocampus...
April 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29677192/the-dyad-adaptive-paced-auditory-serial-addition-test-da-pasat-normative-data-and-the-effects-of-repeated-testing-simulated-malingering-and-traumatic-brain-injury
#3
David L Woods, John M Wyma, Timothy J Herron, E William Yund, Bruce Reed
The Paced Auditory Serial Addition Test (PASAT) is widely used to evaluate processing speed and executive function in patients with multiple sclerosis, traumatic brain injury, and other neurological disorders. In the PASAT, subjects listen to sequences of digits while continuously reporting the sum of the last two digits presented. Four different stimulus onset asynchronies (SOAs) are usually tested, with difficulty increasing as SOAs are reduced. Ceiling effects are common at long SOAs, while the digit delivery rate often exceeds the subject's processing capacity at short SOAs, causing some subjects to stop performing altogether...
2018: PloS One
https://www.readbyqxmd.com/read/29676496/suicide-ideation-in-female-survivors-of-military-sexual-trauma-the-trauma-source-matters
#4
Rebecca K Blais, Lindsey L Monteith
Female veterans who have experienced military sexual trauma (MST) are at elevated suicide risk, yet knowledge is limited regarding correlates of suicide ideation (SI) in this population. MST is associated with a higher risk of posttraumatic stress disorder (PTSD) relative to other trauma types; however, no studies have examined whether experiencing SI differs based on the source of PTSD symptoms (MST-related, non-MST-related). Female service members/veterans (SM/Vs; n = 311) who screened positive for MST and reported exposure to a Criterion A event completed an online survey assessing self-reported demographics, PTSD, depression, the source of their PTSD symptoms, and SI...
April 20, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29676216/developing-a-compassionate-culture-within-pediatric-rehabilitation-does-the-schwartz-rounds%C3%A2-support-both-clinical-and-nonclinical-hospital-workers-in-managing-their-work-experiences
#5
Keith Adamson, Sonia Sengsavang, Sakeena Myers-Halbig, Nancy Searl
Schwartz Rounds™ offers an interprofessional forum for staff to openly engage in discussions about social-emotional aspects of care. We aimed to assess the perceived impact of Rounds in the health care context of pediatric rehabilitation, as well as a comparative analysis of how Rounds affected clinical versus nonclinical staff. Does effect on perceived outcomes was also investigated. Data were collected from 29 hospital staff (15 clinicians, 14 nonclinicians) who attended one, two, or three+ Rounds via semistructured interviews...
April 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29676178/afm-as-a-tool-to-evaluate-the-risk-for-cardiovascular-diseases-in-patients
#6
Ana Filipa Guedes, Luís Sargento, José Braz-Nogueira, Nuno Lousada, Carlos Moreira, Filomena A Carvalho, Nuno C Santos
Erythrocyte aggregation is an indicator of cardiovascular risk, which is influenced by plasma fibrinogen concentration. Fibrinogen levels are elevated during cardiovascular diseases. Our main goals were to understand how fibrinogen-erythrocyte binding influences erythrocyte aggregation and how it constitutes a cardiovascular risk factor in essential arterial hypertension (EAH) and chronic heart failure (CHF). Fibrinogen-erythrocyte and erythrocyte-erythrocyte adhesion measurements were conducted by atomic force microscopy (AFM)-based force spectroscopy...
2018: Annals of Medicine
https://www.readbyqxmd.com/read/29675464/heritable-stress-response-dynamics-revealed-by-single-cell-genealogy
#7
Meenakshi Chatterjee, Murat Acar
Cells often respond to environmental stimuli by activating specific transcription factors. Upon exposure to glucose limitation stress, it is known that yeast Saccharomyces cerevisiae cells dephosphorylate the general stress response factor Msn2, leading to its nuclear localization, which in turn activates the expression of many genes. However, the precise dynamics of Msn2 nucleocytoplasmic translocations and whether they are inherited over multiple generations in a stress-dependent manner are not well understood...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29673666/prevalence-and-factors-associated-with-pregnancy-loss-among-physicians-in-king-abdul-aziz-university-hospital-saudi-arabia
#8
Weam Bashier I Alshora, Bakr Mohammad Kalo
OBJECTIVE: Medical profession is a stressful occupation as it carries potential risk for pregnancy outcome. There is lack of researches regarding the pregnancy loss among physicians working in hospitals in Saudi Arabia. The current study aims at estimating the prevalence and factors associated with pregnancy loss among female physicians working at King Abdul-Aziz University Hospital in Jeddah, September, 2015. MATERIALS AND METHODS: A cross sectional study has been conducted, which included all the female physicians working at King Abdul-Aziz University Hospital in Jeddah by filling a self-administered online questionnaire...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673428/ice-slurry-ingestion-and-physiological-strain-during-exercise-in-non-compensable-heat-stress
#9
Jason Ng, Jonathan E Wingo, Phillip A Bishop, Jason C Casey, Elizabeth K Aldrich
INTRODUCTION: Precooling with ice slurry ingestion attenuates the increase in rectal temperature (Tre) during subsequent running and cycling. It remains unclear how this cooling method affects physiological strain during work while wearing protective garments. This study investigated the effect of ice slurry ingestion on physiological strain during work in hot conditions while wearing firefighter protective clothing. METHODS: In three counterbalanced trials, eight men (mean ± SD; age = 21 ± 2 yr, height = 179...
May 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29673226/evaluation-of-over-the-row-harvester-damage-in-a-super-high-density-olive-orchard-using-on-board-sensing-techniques
#10
Manuel Pérez-Ruiz, Pilar Rallo, M Rocío Jiménez, Miguel Garrido-Izard, M Paz Suárez, Laura Casanova, Constantino Valero, Jorge Martínez-Guanter, Ana Morales-Sillero
New super-high-density (SHD) olive orchards designed for mechanical harvesting using over-the-row harvesters are becoming increasingly common around the world. Some studies regarding olive SHD harvesting have focused on the effective removal of the olive fruits; however, the energy applied to the canopy by the harvesting machine that can result in fruit damage, structural damage or extra stress on the trees has been little studied. Using conventional analyses, this study investigates the effects of different nominal speeds and beating frequencies on the removal efficiency and the potential for fruit damage, and it uses remote sensing to determine changes in the plant structures of two varieties of olive trees (‘Manzanilla Cacereña’ and ‘Manzanilla de Sevilla’) planted in SHD orchards harvested by an over-the-row harvester...
April 17, 2018: Sensors
https://www.readbyqxmd.com/read/29673218/developing-an-extended-model-of-the-relation-between-work-motivation-and-health-as-affected-by-the-work-ability-as-part-of-a-corporate-age-management-approach
#11
Annemarie Feißel, Richard Peter, Enno Swart, Stefanie March
Due to demographic changes, the employee structure in companies is changing dramatically. It will be necessary to offer employees suitable, age-adequate jobs. As one of its foremost goals, optimized business management strategies must create conditions for guaranteeing a person’s health, work ability, and work motivation. In the context of corporate age management concepts, the literature recommends to retain and integrate older employees in the organization. This paper aims at developing an extended model of the relation between work motivation and health as affected by work ability and at deriving a host of measures that enterprises can apply as part of a corporate age management policy to counteract the impact of demographic changes...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29672758/explaining-the-gender-gap-in-sickness-absence
#12
K A Østby, A Mykletun, W Nilsen
Background: In many western countries, women have a much higher rate of sickness absence than men. To what degree the gender differences in sickness absence are caused by gender differences in health is largely unknown. Aims: To assess to what degree the gender gap in sickness absence can be explained by health factors and work- and family-related stressors. Methods: Norwegian parents participating in the Tracking Opportunities and Problems (TOPP) study were asked about sickness absence and a range of factors possibly contributing to gender differences in sickness absence, including somatic and mental health, sleep problems, job control/demands, work-home conflicts, parent-child conflicts and stressful life events...
April 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29672747/stress-in-patients-with-un-ruptured-intracranial-aneurysms-vs-population-based-controls
#13
Arno de Wilde, Paut Greebe, Gabriël J E Rinkel, Ale Algra
BACKGROUND: Stress is associated with increased risk of stroke and might predispose to presence and rupture of intracranial aneurysms. OBJECTIVE: To study the association of recent and lifelong stress with unruptured intracranial aneurysm (UIA) and aneurysmal subarachnoid hemorrhage (ASAH). METHODS: In 227 UIA patients (mean age 61 ± 11 yr), 490 ASAH patients (59 ± 11 yr), and 775 controls (51 ± 15 yr) who were randomly retrieved from the general population, we assessed occurrence of major life events and perceived stress during the preceding 12 mo and the entire life...
April 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29672625/mechanistic-studies-of-depr-in-regulating-fk228-biosynthesis-in-chromobacterium-violaceum-no-968
#14
Yongjian Qiao, Tiantian Tong, Jiao Xue, Wenjing Lin, Zixin Deng, Yi-Qiang Cheng, Dongqing Zhu
DepR, a LysR-type transcriptional regulator encoded by the last gene of the putative min operon (orf21-20-19-depR) located at the downstream region of the anticancer agent FK228 biosynthetic gene cluster in Chromobacterium violaceum No. 968, positively regulates the biosynthesis of FK228. In this work, the mechanism underlining this positive regulation was probed by multiple approaches. Electrophoretic mobility shift assay (EMSA) and DNase I footprinting assay (DIFA) identified a conserved 35-nt DNA segment in the orf21-orf22 intergenic region where the purified recombinant DepR binds to...
2018: PloS One
https://www.readbyqxmd.com/read/29671835/microfluidic-synthesis-of-ca-alginate-microcapsules-for-self-healing-of-bituminous-binder
#15
Benan Shu, Shaopeng Wu, Lijie Dong, Qing Wang, Quantao Liu
This work aims to develop an original alginate micro-emulsion combining with droplets microfluidic method to produce multinuclear Ca-alginate microcapsules containing rejuvenator for the self-healing of bituminous binder. The sizes of the Ca-alginate microcapsules could be easily controlled by tuning flow rates of the continuous and dispersed phases. The addition of a surfactant Tween80 not only improved the stability of the emulsion, but it also effectively reduced the size of the microcapsules. Size predictive mathematical model of the microcapsules was proposed through the analysis of fluid force...
April 19, 2018: Materials
https://www.readbyqxmd.com/read/29670748/factors-associated-with-healthy-and-unhealthy-workplace-eating-behaviours-in-individuals-with-overweight-obesity-with-and-without-binge-eating-disorder
#16
S L Leung, J A Barber, A Burger, R D Barnes
Objective: Most Americans spend an average of 8 hours per day in the workplace. Current understanding of eating behaviours in the workplace and their association with overweight, obesity and binge eating disorder (BED) is limited. Workplace eating behaviours and weight-related self-efficacy were examined in a sample of 98 individuals with overweight or obesity, with or without BED. Design: Participants completed the Weight Efficacy Lifestyle Questionnaire, Work and Social Adjustment Scale, Worker's Perception of Environmental Factors, and a Workplace Questionnaire...
April 2018: Obesity Science & Practice
https://www.readbyqxmd.com/read/29670457/genomic-prediction-applied-to-high-biomass-sorghum-for-bioenergy-production
#17
Amanda Avelar de Oliveira, Maria Marta Pastina, Vander Filipe de Souza, Rafael Augusto da Costa Parrella, Roberto Willians Noda, Maria Lúcia Ferreira Simeone, Robert Eugene Schaffert, Jurandir Vieira de Magalhães, Cynthia Maria Borges Damasceno, Gabriel Rodrigues Alves Margarido
The increasing cost of energy and finite oil and gas reserves have created a need to develop alternative fuels from renewable sources. Due to its abiotic stress tolerance and annual cultivation, high-biomass sorghum ( Sorghum bicolor L. Moench) shows potential as a bioenergy crop. Genomic selection is a useful tool for accelerating genetic gains and could restructure plant breeding programs by enabling early selection and reducing breeding cycle duration. This work aimed at predicting breeding values via genomic selection models for 200 sorghum genotypes comprising landrace accessions and breeding lines from biomass and saccharine groups...
2018: Molecular Breeding: New Strategies in Plant Improvement
https://www.readbyqxmd.com/read/29669966/effect-of-the-national-stress-check-program-on-mental-health-among-workers-in-japan-a-1-year-retrospective-cohort-study
#18
Kotaro Imamura, Yumi Asai, Kazuhiro Watanabe, Akizumi Tsutsumi, Akihito Shimazu, Akiomi Inoue, Hisanori Hiro, Yuko Odagiri, Toru Yoshikawa, Etsuko Yoshikawa, Norito Kawakami
OBJECTIVES: This retrospective cohort study evaluated the impact of the Stress Check Program, a recently introduced national policy and program aimed at reducing psychological distress among Japanese workers. METHODS: A baseline survey was conducted from November 2015 to February 2016, the period when Japan began enforcing the Stress Check Program. A one-year follow-up survey was conducted in December 2016. In the follow-up survey, two exposure variables were collected: having taken the annual stress survey, and experiencing an improvement in the psychosocial work environment...
April 18, 2018: Journal of Occupational Health
https://www.readbyqxmd.com/read/29669617/does-a-modified-mindfulness-based-cognitive-therapy-mbct-course-have-the-potential-to-reduce-stress-and-burnout-in-nhs-gps-feasibility-study
#19
Kate Hamilton-West, Tracy Pellatt-Higgins, Neil Pillai
AimTo explore, for the first time, whether a modified mindfulness-based cognitive therapy (MBCT) course has the potential to reduce stress and burnout among National Health Service (NHS) General Practitioners. BACKGROUND: There is a crisis of low morale among NHS GPs, with most describing their workload as 'unmanageable'. MBCT has been demonstrated to improve stress and burnout in other populations, but has not yet been evaluated in a cohort of NHS GPs. METHODS: NHS GPs in South East England (n=22) attended a modified version of the MBCT course approved by National Institute for Health and Care Excellence for prevention of depressive relapse...
April 19, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29669182/secondary-traumatic-stress-and-burnout-among-refugee-resettlement-workers-the-role-of-coping-and-emotional-intelligence
#20
Adeyinka M Akinsulure-Smith, Adriana Espinosa, Tracy Chu, Ryan Hallock
To promote a better understanding of the impact of refugee resettlement work on refugee resettlement workers, this study examined the prevalence rates of deleterious mental health and occupational outcomes, such as secondary traumatic stress and burnout, among a sample of 210 refugee resettlement workers at six refugee resettlement agencies in the United States. The study also explored coping mechanisms used by service providers to manage work-related stress and the influence of such strategies and emotional intelligence on secondary traumatic stress and burnout...
April 2018: Journal of Traumatic Stress
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