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https://www.readbyqxmd.com/read/28944976/obesity-and-frontal-striatal-brain-structures-in-offspring-of-individuals-with-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#1
Rodrigo B Mansur, Roger S McIntyre, Bo Cao, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
OBJECTIVES: To compare frontal-striatal brain volumes between offspring of individuals with bipolar disorder (BD) and healthy controls; to investigate the associations of body mass index (BMI) and age with brain volumes; and to assess the moderating effects of BMI and age on the relationship between risk status and structural brain differences. METHODS: We cross-sectionally assessed structural regional and global brain volumes using magnetic resonance imaging and BMI among 53 BD offspring subjects, stratified by risk status, and 23 non-BD offspring controls (aged 8-28 years)...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944857/a-novel-fbn1-mutation-causes-autosomal-dominant-marfan-syndrome
#2
Ying Xiao, Xiaoqi Liu, Xiaoxin Guo, Liping Liu, Linxin Jiang, Qi Wang, Bo Gong
Marfan syndrome (MFS) is an inherited and systemic disorder. It has been reported that mutations in the fibrillin‑1 gene (FBN1) account for ~90% of autosomal dominant cases of MFS. This study was conducted to screen mutations of FBN1 in a Chinese family with autosomal dominant MFS; four individuals including two patients with MFS were recruited. The family members underwent complete physical, cardiovascular and ophthalmologic examinations. Genomic DNA samples were collected from the family along with 383 unrelated healthy subjects...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944592/estimating-the-prevalence-of-borderline-personality-disorder-in-mothers-involved-in-youth-protection-services
#3
Lise Laporte, Joel Paris, Phyllis Zelkowitz
Characteristics of borderline personality disorder (BPD) can undermine maternal capacity and in some cases lead to involvement with youth protection services (YPS). Yet, few studies exist on the prevalence of maternal BPD in this context and on the comparison of these families with families with other maternal psychiatric disorders or families with no mental illness within YPS. The current study surveyed 291 caseworkers working with mothers whose children and adolescents are followed by YPS. After reported prevalence was adjusted with validation procedures, the prevalence of maternal BPD in a sample of 1875 mothers was 34...
September 24, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28944527/psychophysiological-changes-during-pure-vs-guided-mirror-exposure-therapies-in-women-with-high-body-dissatisfaction-what-are-they-learning-about-their-bodies
#4
Sandra Díaz-Ferrer, Sonia Rodríguez-Ruiz, Blanca Ortega-Roldán, José Luis Mata-Martín, M Carmen Fernández-Santaella
This study aimed to examine the psychophysiological changes resulting from two mirror exposure treatments that are effective at reducing body dissatisfaction. Thirty-five university women with body dissatisfaction and subclinical eating disorders were randomly assigned to one of two groups: pure (n = 17) or guided exposure (n = 18). The participants received six sessions of treatment. Their thoughts, feelings and avoidance behaviours were assessed after each session. Their subjective discomfort, heart rate and skin conductance were assessed within the sessions...
September 24, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28944401/molecular-and-cellular-effects-of-traumatic-stress-implications-for-ptsd
#5
REVIEW
Matthew J Girgenti, Brendan D Hare, Sriparna Ghosal, Ronald S Duman
PURPOSE OF REVIEW: Posttraumatic stress disorder (PTSD) is characterized by hyperarousal and recurrent stressful memories after an emotionally traumatic event. Extensive research has been conducted to identify the neurobiological determinants that underlie the pathophysiology of PTSD. In this review, we examine evidence regarding the molecular and cellular pathophysiology of PTSD focusing on two primary brain regions: the vmPFC and the amygdala. RECENT FINDINGS: This discussion includes a review of the molecular alterations related to PTSD, focusing mainly on changes to glucocorticoid receptor signaling...
September 25, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28944253/psychological-assessment-of-patients-with-biotin-thiamine-responsive-basal-ganglia-disease
#6
Majid Alfadhel, Amal Al-Bluwi
Biotin-thiamine-responsive basal ganglia disease is a devastating autosomal recessive inherited neurological disorder. We conducted a retrospective chart review of all patients with biotin-thiamine-responsive basal ganglia disease who underwent a formal psychological assessment. Six females and 3 males were included. Five patients (56%) had an average IQ, two patients (22%) had mild delay, and two (22%) had severe delay. A normal outcome was directly related to the time of diagnosis and initiation of treatment...
January 2017: Child neurology open
https://www.readbyqxmd.com/read/28944234/the-nextgen-study-patient-motivation-for-participation-in-genome-sequencing-for-carrier-status
#7
Tia L Kauffman, Stephanie A Irving, Michael C Leo, Marian J Gilmore, Patricia Himes, Carmit K McMullen, Elissa Morris, Jennifer Schneider, Benjamin S Wilfond, Katrina A B Goddard
BACKGROUND: While translational genomic sequencing research is increasing, few studies have been limited to healthy individuals; most have focused on patients with a disease or a strong family history of a disorder. The limited studies that have included healthy individuals have focused on the disclosure of medically actionable secondary results, rather than carrier status, to assess reproductive risks. To address this important gap, we conducted the NextGen study, which focuses on carrier status and medically actionable secondary findings in a population of women planning a pregnancy...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28943889/-if-there-s-no-stability-around-them-experienced-therapists-view-on-the-role-of-patients-social-world-in-recovery-in-bipolar-disorder
#8
Marius Veseth, Per-Einar Binder, Signe Hjelen Stige
BACKGROUND: Recovery in severe mental illness has traditionally been described as a deeply personal process. At the same time, researchers are increasingly attending to the social nature of such processes. In this article, we aim to supplement the growing knowledge base regarding these social aspects by exploring the perspectives of experienced therapists: how do they view the role of the social world in processes of healing and growth for people with bipolar disorder? And in what ways can the social world impede recovery? METHODS: We conducted 12 semi-structured individual interviews and analyzed the resulting transcripts using a team-based thematic analysis method...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28943292/enhanced-fear-and-altered-neuronal-activation-in-forebrain-limbic-regions-of-cx3cr1-deficient-mice
#9
Inga Schubert, Rebecca Ahlbrand, Andrew Winter, Lauren Vollmer, Ian Lewkowich, Renu Sah
Mounting evidence supports immune dysfunction in psychiatric conditions such as post-traumatic stress disorder (PTSD). The association of immunomodulatory mechanisms with PTSD-relevant behavior and physiology is not well understood. Communication between neurons and microglia, resident immune cells of the central nervous system, is crucial for optimal regulation of behavior and physiology. In this regard, the fractalkine CX3CL1, secreted from neurons and its target, the microglial CX3CR1 receptor represent a primary neuron-microglia inter-regulatory system important for synaptic plasticity and function...
September 21, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28943103/lower-vertebrate-and-invertebrate-models-of-alzheimer-s-disease-a-review
#10
REVIEW
Neha Sharma, Navneet Khurana, Arunachalam Muthuraman
Alzheimer's disease is a common neurodegenerative disorder which is characterized by the presence of beta- amyloid protein and neurofibrillary tangles (NFTs) in the brain. Till now, various higher vertebrate models have been in use to study the pathophysiology of this disease. But, these models possess some limitations like ethical restrictions, high cost, difficult maintenance of large quantity and lesser reproducibility. Besides, various lower chordate animals like Danio rerio, Drosophila melanogaster, Caenorhabditis elegans and Ciona intestinalis have been proved to be an important model for the in vivo determination of targets of drugs with least limitations...
September 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28942704/why-people-who-inject-drugs-voluntarily-transition-off-methadone-in-ukraine
#11
Julia Rozanova, Ruthanne Marcus, Faye S Taxman, Martha J Bojko, Lynn Madden, Scott O Farnum, Alyona Mazhnaya, Sergii Dvoriak, Frederick L Altice
Methadone maintenance therapy (MMT) treats opioid use disorder among people who inject drugs (PWID). To understand why PWID may voluntarily discontinue MMT, we analyzed data from 25 focus groups conducted in five Ukrainian cities from February to April 2013 with 199 participants who were currently, previously, or never on MMT. Using constant comparison method, we uncovered three themes explaining why PWID transition off MMT: (a) purposeful resistance to rigid social control associated with how MMT is delivered and to power asymmetries in provider-patient relationships, (b) self-management of a PWID's "wounded identity" that is common in socially stigmatized and physically sick persons-MMT serves as a reminder of their illness, and (c) the quest for a "normal life" uninterrupted by daily MMT site visits, harassment, and time inefficiencies, resources, and social capital...
September 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28942289/polysubstance-use-by-psychiatry-inpatients-with-co-occurring-mental-health-and-substance-use-disorders
#12
Christine Timko, Mark Ilgen, Marie Haverfield, Alexandra Shelley, Jessica Y Breland
BACKGROUND: Polysubstance use, the consumption of more than one substance over a defined period, is common and associated with psychiatric problems and poor treatment adherence and outcomes. This study examined past-month polysubstance use at intake among psychiatry inpatients with co-occurring mental health and substance use disorders, and outcomes 3 months later. METHODS: Participants (n=406 psychiatry inpatients with documented mental health and substance use disorders) completed a baseline and a 3-month follow-up (84%) interview...
September 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28942135/a-medicinal-plant-compound-capnoidine-prevents-the-onset-of-inflammation-in-a-mouse-model-of-colitis
#13
Catherine Shepherd, Paul Giacomin, Severine Navarro, Catherine Miller, Alex Loukas, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional uses of Corydalis dubia, Ajania nubigena and Pleurospermum amabile in the Bhutanese traditional medicine for treating disorders related to inflammatory conditions and the in vitro anti-inflammatory activity of their crude extracts inspired the isolation and the investigation of anticolitic properties of four pure compounds. MATERIALS AND METHODS: Three medicinal plants were collected from Himalayan Mountains of Bhutan...
September 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28942057/psychosocial-symptoms-in-very-young-children-assessed-for-sexual-abuse-a-qualitative-analysis-from-the-asac-study
#14
T F Vrolijk-Bosschaart, S N Brilleslijper-Kater, G A M Widdershoven, A H Teeuw, E Verlinden, Y Voskes, E M van Duin, A P Verhoeff, M de Leeuw, M J Roskam, M A Benninga, R J L Lindauer
Child sexual abuse (CSA) is a worldwide problem with serious consequences. No recognizable symptom pattern for suspected CSA has yet been identified in very young children. We aim to investigate psychosocial symptoms in a sample of children with confirmed or strongly suspected CSA and the interpretations given to such symptoms by independent clinical experts. Secondly we examined whether experts were able to identify confirmed victims of severe CSA. A qualitative study including inductive content analysis of medical files and focus group discussions with independent experts on the interpretation of psychosocial symptoms was conducted...
September 20, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28941927/emotion-regulation-as-a-transdiagnostic-treatment-construct-across-anxiety-depression-substance-eating-and-borderline-personality-disorders-a-systematic-review
#15
REVIEW
Elise Sloan, Kate Hall, Richard Moulding, Shayden Bryce, Helen Mildred, Petra K Staiger
A large body of research has implicated difficulties in emotion regulation as central to the development and maintenance of psychopathology. Emotion regulation has therefore been proposed as a transdiagnostic construct or an underlying mechanism in psychopathology. The transdiagnostic role of emotion regulation has yet to be systematically examined within the psychological treatment outcome literature. It can be proposed that if emotion regulation is indeed a transdiagnostic construct central to the maintenance of psychopathology, then changes in emotion regulation difficulties will occur after effective treatment and this will occur for different disorders...
September 11, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28941119/sedentary-behavior-and-physical-activity-levels-in-people-with-schizophrenia-bipolar-disorder-and-major-depressive-disorder-a-global-systematic-review-and-meta-analysis
#16
Davy Vancampfort, Joseph Firth, Felipe B Schuch, Simon Rosenbaum, James Mugisha, Mats Hallgren, Michel Probst, Philip B Ward, Fiona Gaughran, Marc De Hert, André F Carvalho, Brendon Stubbs
People with severe mental illness (schizophrenia, bipolar disorder or major depressive disorder) die up to 15 years prematurely due to chronic somatic comorbidities. Sedentary behavior and low physical activity are independent yet modifiable risk factors for cardiovascular disease and premature mortality in these people. A comprehensive meta-analysis exploring these risk factors is lacking in this vulnerable population. We conducted a meta-analysis investigating sedentary behavior and physical activity levels and their correlates in people with severe mental illness...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28941006/palonosetron-is-nonsuperior-to-ondansetron-in-acute-phase-but-provides-superior-antiemetic-control-in-delayed-phase-for-pediatric-patients-administered-highly-emetogenic-chemotherapy
#17
Juan Tan, Shan Wang, Xiaohua Liang, Chang-Chun Li, Jun Zhang, Zhenzhen Zhao, Xiang-Ru Kong, Xiaobin Deng, Liang Peng, Chao Yang
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) in children remains to be a major side effect despite antiemetic treatment. Palonosetron is a new generation 5-HT3 receptor antagonists effective against acute and delayed nausea and vomiting. This study aimed to compare the therapeutic values of palonosetron and ondansetron in preventing pediatric CINV. METHODS: A prospective, randomized, double-blind, parallel controlled study was conducted in 0-18 years old cancer patients administered highly emetogenic chemotherapy, with different dosage of palonosetron or ondansetron, both followed by dexamethasone...
September 22, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28940680/correlation-between-direction-and-severity-of-temporomandibular-joint-disc-displacement-and-reduction-ability-during-mouth-opening
#18
Monika Litko, Marcin Berger, Jacek Szkutnik, Ingrid Różyło-Kalinowska
BACKGROUND: The most common temporomandibular joint (TMJ) internal derangement is an abnormal relationship of the disc with respect to the mandibular condyle, articular eminence, and glenoid fossa - disc displacement. OBJECTIVE: The aim of our study is to analyse the correlation between partial/complete disc displacement in the intercuspal position (IP) and its reduction in the open mouth position (OMP) in both oblique-sagittal and coronal plane on magnetic resonance imaging (MRI) in patients with temporomandibular disorders...
September 23, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28940637/the-internet-game-use-elicited-symptom-screen-proved-to-be-a-valid-tool-for-adolescents-aged-10-19-years
#19
Sun-Jin Jo, Hyeon Woo Yim, Hae-Kook Lee, Hyung Cho Lee, Jung-Seok Choi, Kyung-Young Baek
AIM: This study tested the diagnostic validity of the nine-item Internet Game Use-Elicited Symptom Screen (IGUESS) tool, which was developed by the authors after the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, identified Internet gaming as a condition that needed further study. METHODS: A self-report screening test comprising IGUESS and the Young's Internet Addiction Test was administered to 121 adolescents (74% boys) with a median age of 14 (range 10 to 19) recruited from school and health settings in Korea, After the screening, a clinician conducted one-to-one interviews with all of the subjects to set a gold standard for diagnosis...
September 21, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28940168/genetics-of-anorexia-nervosa
#20
REVIEW
Jessica H Baker, Katherine Schaumberg, Melissa A Munn-Chernoff
PURPOSE OF REVIEW: Genetic factors contribute to the etiology of anorexia nervosa (AN). This review synthesizes the current state of knowledge about the genetic etiology of AN, provides directions for future research, and discusses clinical implications for this research. RECENT FINDINGS: Candidate gene meta-analyses indicate serotonin genes may be involved in the genetic etiology of AN. Three genome-wide association studies have been conducted and one genome-wide significant locus was identified...
September 22, 2017: Current Psychiatry Reports
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