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https://www.readbyqxmd.com/read/29780858/can-visuospatial-measures-improve-the-diagnosis-of-alzheimer-s-disease
#1
REVIEW
Shirin Salimi, Muireann Irish, David Foxe, John R Hodges, Olivier Piguet, James R Burrell
Introduction: Overlapping and evolving symptoms lead to ambiguity in the diagnosis of dementia. Visuospatial function relies on parietal lobe function, which may be affected in the early stages of Alzheimer's disease (AD). This review evaluates visuospatial dysfunction in patients with AD, frontotemporal dementia, dementia with Lewy bodies, and vascular dementia to determine the diagnostic and prognostic potential of visuospatial tasks in AD. Methods: A systematic search of studies (1960-2016) investigating visuospatial dysfunction in dementia was conducted...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29769701/a-drosophila-model-of-essential-tremor
#2
Philip Smith, Ronald Arias, Shilpa Sonti, Zagaa Odgerel, Ismael Santa-Maria, Brian D McCabe, Krasimira Tsaneva-Atanasova, Elan D Louis, James J L Hodge, Lorraine N Clark
Essential Tremor (ET) is one of the most common neurological diseases, with an estimated 7 million affected individuals in the US; the pathophysiology of the disorder is poorly understood. Recently, we identified a mutation (KCNS2 (Kv9.2), c.1137 T > A, p.(D379E) in an electrically silent voltage-gated K+ channel α-subunit, Kv9.2, in a family with ET, that modulates the activity of Kv2 channels. We have produced transgenic Drosophila lines that express either the human wild type Kv9.2 (hKv9.2) or the ET causing mutant Kv9...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29728649/small-molecule-modulators-of-%C3%AF-2r-tmem97-reduce-alcohol-withdrawal-induced-behaviors
#3
Luisa L Scott, James J Sahn, Antonio Ferragud, Rachel C Yen, Praveen N Satarasinghe, Michael D Wood, Timothy R Hodges, Ted Shi, Brooke A Prakash, Kaitlyn M Friese, Angela Shen, Valentina Sabino, Jonathan T Pierce, Stephen F Martin
Repeated cycles of intoxication and withdrawal enhance the negative reinforcing properties of alcohol and lead to neuroadaptations that underlie withdrawal symptoms driving alcohol dependence. Pharmacotherapies that target these neuroadaptations may help break the cycle of dependence. The sigma-1 receptor (σ1R) subtype has attracted interest as a possible modulator of the rewarding and reinforcing effects of alcohol. However, whether the sigma-2 receptor, recently cloned and identified as transmembrane protein 97 (σ2R/TMEM97), plays a role in alcohol-related behaviors is currently unknown...
April 20, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29728368/-in-vivo-expansion-of-functionally-integrated-gabaergic-interneurons-by-targeted-increase-in-neural-progenitors
#4
Rachel E Shaw, Benjamin Kottler, Zoe N Ludlow, Edgar Buhl, Dongwook Kim, Sara Morais da Silva, Alina Miedzik, Antoine Coum, James Jl Hodge, Frank Hirth, Rita Sousa-Nunes
A central hypothesis for brain evolution is that it might occur via expansion of progenitor cells and subsequent lineage-dependent formation of neural circuits. Here, we report in vivo amplification and functional integration of lineage-specific circuitry in Drosophila Levels of the cell fate determinant Prospero were attenuated in specific brain lineages within a range that expanded not only progenitors but also neuronal progeny, without tumor formation. Resulting supernumerary neural stem cells underwent normal functional transitions, progressed through the temporal patterning cascade, and generated progeny with molecular signatures matching source lineages...
May 4, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29696771/risk-factors-for-the-development-of-paclitaxel-induced-neuropathy-in-breast-cancer-patients
#5
Jetter Robertson, Jeffrey Raizer, James S Hodges, William Gradishar, Jeffrey A Allen
No abstract text is available yet for this article.
April 25, 2018: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29694463/predictors-of-long-term-temporomandibular-disorder-pain-intensity-an-8-year-cohort-study
#6
Flavia P Kapos, John O Look, Lei Zhang, James S Hodges, Eric L Schiffman
AIMS: To investigate, in individuals with pain-related temporomandibular disorder (TMD), the association of long-term pain intensity with baseline health-related quality of life (HRQoL) and jaw functional limitation. METHODS: Of 513 cases with baseline pain-related TMD (masticatory muscle and/or temporomandibular joint [TMJ] pain), 273 were reevaluated after 8 years, and 258 of them had complete baseline data for Jaw Functional Limitation Scale (JFLS) scores and HRQoL measured by the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the 12-item Short Form Health Survey and follow-up data for Characteristic Pain Intensity (CPI) from the Graded Chronic Pain Scale...
April 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29661107/implementation-of-health-information-exchange-at-the-pima-county-adult-detention-complex-lessons-learned
#7
Alyssa Hinchman, Sara Hodges, James Backus, Terri Warholak
Successful transition of patients between health care entities is difficult. Historically, the process of transitioning individuals through the corrections system with regard to health care was made even more challenging by the limitation of paper records. Recently, the advent of electronic medical records has improved health care nationwide. The use of health information exchange (HIE) systems in areas such as emergency medicine has also impacted patient outcomes. To date, this technology has not been used in the corrections system...
April 2018: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/29628142/a-kinesin-14-motor-activates-neocentromeres-to-promote-meiotic-drive-in-maize
#8
R Kelly Dawe, Elizabeth G Lowry, Jonathan I Gent, Michelle C Stitzer, Kyle W Swentowsky, David M Higgins, Jeffrey Ross-Ibarra, Jason G Wallace, Lisa B Kanizay, Magdy Alabady, Weihong Qiu, Kuo-Fu Tseng, Na Wang, Zhi Gao, James A Birchler, Alex E Harkess, Amy L Hodges, Evelyn N Hiatt
Maize abnormal chromosome 10 (Ab10) encodes a classic example of true meiotic drive that converts heterochromatic regions called knobs into motile neocentromeres that are preferentially transmitted to egg cells. Here, we identify a cluster of eight genes on Ab10, called the Kinesin driver (Kindr) complex, that are required for both neocentromere motility and preferential transmission. Two meiotic drive mutants that lack neocentromere activity proved to be kindr epimutants with increased DNA methylation across the entire gene cluster...
April 2, 2018: Cell
https://www.readbyqxmd.com/read/29622758/lumbar-spine-bone-mineral-density-z-score-discrepancies-by-dual-x-ray-absorptiometry-do-not-predict-vertebral-fractures-in-children
#9
Tasma Harindhanavudhi, Anna Petryk, Richard Jones, Amanda R Wallin, James S Hodges, Sara Van Nortwick, Bradley S Miller, Tara L Holm, Kyriakie Sarafoglou
Dual X-ray absorptiometry (DXA) remains the most common mode of bone mineral density (BMD) evaluation. In adults, presence of a lumbar spine (LS) BMD T-score discrepancy (>1 SD difference between adjacent vertebrae) can indicate a vertebral fracture. In children, however, the clinical significance of such discrepancies is unknown. We conducted a retrospective study to evaluate the association between LS DXA and LS morphology to elucidate the clinical significance of an LS BMD Z-score discrepancy. We identified 360 DXA scans performed between September 2014 and May 2016 in patients 5-18 years of age...
April 4, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29618084/the-rationale-for-janus-kinase-inhibitors-for-the-treatment-of-spondyloarthritis
#10
Douglas J Veale, Dennis McGonagle, Iain B McInnes, James G Krueger, Christopher T Ritchlin, Dirk Elewaut, Keith S Kanik, Thijs Hendrikx, Gabriel Berstein, Jennifer Hodge, Jean-Baptiste Telliez
The pathogenesis of SpA is multifactorial and involves a range of immune cell types and cytokines, many of which utilize Janus kinase (JAK) pathways for signaling. In this review, we summarize the animal and pre-clinical data that have demonstrated the effects of JAK blockade on the underlying molecular mechanisms of SpA and provide a rationale for JAK inhibition for the treatment of SpA. We also review the available clinical trial data evaluating JAK inhibitors tofacitinib, baricitinib, peficitinib, filgotinib and upadacitinib in PsA, AS and related inflammatory diseases, which have demonstrated the efficacy of these agents across a range of SpA-associated disease manifestations...
April 3, 2018: Rheumatology
https://www.readbyqxmd.com/read/29617053/efficacy-and-safety-of-rivaroxaban-compared-to-enoxaparin-in-treatment-of-cancer-associated-venous-thromboembolism
#11
Benjamin Simmons, Waldemar Wysokinski, Rayya A Saadiq, Dalene Bott-Kitslaar, Stanislav Henkin, Ana Casanegra, Charles Lenz, Paul Daniels, Haraldur Bjarnason, Emily Vargas, David Hodge, Sara J Holton, James R Cerhan, Charles Loprinzi, Robert McBane
BACKGROUND: Low molecular weight heparin (LMWH) is the guideline endorsed treatment for cancer associated venous thromboembolism (cVTE). Study objectives were to compare the efficacy and safety of rivaroxaban and enoxaparin in cVTE. METHODS: Using a cohort study design, consecutive patients with cVTE (3/1/2013-7/31/2016), enrolled in the Mayo Thrombophilia Clinic Direct Oral Anticoagulants Registry were compared to contemporary cancer patients receiving enoxaparin...
April 4, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29582074/enforcing-federal-drug-laws-in-states-where-medical-marijuana-is-lawful
#12
Lawrence O Gostin, James G Hodge, Sarah A Wetter
No abstract text is available yet for this article.
March 26, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29566152/mutations-in-the-mitochondrial-ribosomal-protein-mrps22-lead-to-primary-ovarian-insufficiency
#13
Anlu Chen, Dov Tiosano, Tulay Guran, Hagit N Baris, Yavuz Bayram, Adi Mory, Laura Shapiro-Kulnane, Craig A Hodges, Zeynep Coban Akdemir, Serap Turan, Shalini N Jhangiani, Focco van den Akker, Charles L Hoppel, Helen K Salz, James R Lupski, David A Buchner
Primary ovarian insufficiency (POI) is characterized by amenorrhea and loss or dysfunction of ovarian follicles prior to the age of 40. POI has been associated with autosomal recessive mutations in genes involving hormonal signaling and folliculogenesis, however the genetic etiology of POI most often remains unknown. Here we report MRPS22 homozygous missense variants c.404G>A (p.R135Q) and c.605G>A (p.R202H) identified in four females from two independent consanguineous families as a novel genetic cause of POI in adolescents...
March 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29544907/mendelian-adult-onset-leukodystrophy-genes-in-alzheimer-s-disease-critical-influence-of-csf1r-and-notch3
#14
Celeste Sassi, Michael A Nalls, Perry G Ridge, Jesse R Gibbs, Michelle K Lupton, Claire Troakes, Katie Lunnon, Safa Al-Sarraj, Kristelle S Brown, Christopher Medway, Jenny Lord, James Turton, Jose Bras, Sonja Blumenau, Mareike Thielke, Christa Josties, Dorette Freyer, Annette Dietrich, Monia Hammer, Michael Baier, Ulrich Dirnagl, Kevin Morgan, John F Powell, John S Kauwe, Carlos Cruchaga, Alison M Goate, Andrew B Singleton, Rita Guerreiro, Angela Hodges, John Hardy
Mendelian adult-onset leukodystrophies are a spectrum of rare inherited progressive neurodegenerative disorders affecting the white matter of the central nervous system. Among these, cerebral autosomal dominant and recessive arteriopathy with subcortical infarcts and leukoencephalopathy, cerebroretinal vasculopathy, metachromatic leukodystrophy, hereditary diffuse leukoencephalopathy with spheroids, and vanishing white matter disease present with rapidly progressive dementia as dominant feature and are caused by mutations in NOTCH3, HTRA1, TREX1, ARSA, CSF1R, EIF2B1, EIF2B2, EIF2B3, EIF2B4, and EIF2B5, respectively...
February 2, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29534270/intra-articular-alpha-2-agonists-as-an-adjunct-to-local-anesthetic-in-knee-arthroscopy-a-systematic-review-and-meta-analysis
#15
Thomas James Ryan, Rhys Holyoak, Ruan Vlok, Thomas Melhuish, Anthony Hodge, Matthew Binks, Glenn Hurtado, Leigh White
The infiltration of local anesthetic has been shown to reduce postoperative pain in knee arthroscopy. Several studies have shown that the addition of agents such as magnesium and nonsteroidal antiinflammatory drugs (NSAIDs) result in an increased time to first analgesia and overall reduction in pain. The aim of this systematic review and meta-analysis was to determine whether the addition of an α-2 agonist (A2A) to intra-articular local anesthetic, results in a reduction in postoperative pain. Four major databases were systematically searched for relevant randomized controlled trials (RCTs) up to July 2017...
March 13, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29532522/low-prevalence-of-diabetes-distress-following-total-pancreatectomy-with-islet-autotransplantation
#16
Audrey Lane, James S Hodges, Peggy Ptacek, K Louise Berry, Gregory J Beilman, Ty B Dunn, Timothy L Pruett, Srinath Chinnakotla, Barbara Kuzmak, Melena D Bellin
Diabetes distress (DD), or psychological fatigue associated with diabetes management, is common in type 1 and 2 diabetes mellitus and is associated with poor glycemic control. Diabetes distress has never been evaluated in patients undergoing total pancreatectomy with islet autotransplant (TPIAT) for chronic pancreatitis. We analyzed DD after TPIAT in 260 patients (average age 34.3 [standard deviation 15], 75.5% F) undergoing TPIAT between 2006 and 2014. Each patient completed 1 or more diabetes distress scale (DDS) questionnaires from 1 to 7 years post-TPIAT (631 total)...
March 13, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29518577/reversibility-of-peripheral-blood-leukocyte-phenotypic-and-functional-changes-after-exposure-to-and-withdrawal-from-tofacitinib-a-janus-kinase-inhibitor-in-healthy-volunteers
#17
Kent J Weinhold, Jack F Bukowski, Todd V Brennan, Robert J Noveck, Janet S Staats, Liwen Lin, Linda Stempora, Constance Hammond, Ann Wouters, Christopher F Mojcik, John Cheng, Mark Collinge, Michael I Jesson, Anasuya Hazra, Pinaki Biswas, Shuping Lan, James D Clark, Jennifer A Hodge
This study evaluated the short-term effects of tofacitinib treatment on peripheral blood leukocyte phenotype and function, and the reversibility of any such effects following treatment withdrawal in healthy volunteers. Cytomegalovirus (CMV)-seropositive subjects received oral tofacitinib 10 mg twice daily for 4 weeks and were followed for 4 weeks after drug withdrawal. There were slight increases in total lymphocyte and total T-cell counts during tofacitinib treatment, and B-cell counts increased by up to 26%...
June 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29517634/age-and-disease-duration-impact-outcomes-of-total-pancreatectomy-and-islet-autotransplant-for-prss1-hereditary-pancreatitis
#18
Melena D Bellin, Polina Prokhoda, James S Hodges, Sarah J Schwarzenberg, Martin L Freeman, Ty B Dunn, Joshua J Wilhelm, Timothy L Pruett, Varvara A Kirchner, Gregory J Beilman, Srinath Chinnakotla
OBJECTIVES: We investigated the impact of patient age and disease duration on islet isolation results, diabetes outcomes, and pain outcomes after total pancreatectomy with islet autotransplant (TPIAT) performed in 64 patients with hereditary pancreatitis due to PRSS1 gene mutation. METHODS: We evaluated the association of patient age and disease duration on islet isolation results and opioid use at 1 year using logistic regression and on graft function using 1-way analysis of variance...
April 2018: Pancreas
https://www.readbyqxmd.com/read/29498261/nist-standards-for-measurement-instrument-calibration-and-quantification-of-gaseous-atmospheric-compounds
#19
George C Rhoderick, Michael E Kelley, Walter R Miller, James E Norris, Jennifer Carney, Lyn Gameson, Christina E Cecelski, Kimberly J Harris, Cassie A Goodman, Abneesh Srivastava, Joseph T Hodges
There are many gas phase compounds present in the atmosphere that affect and influence the earth's climate. These compounds absorb and emit radiation, a process which is the fundamental cause of the greenhouse effect. The major greenhouse gases in the earth's atmosphere are carbon dioxide, methane, nitrous oxide, and ozone. Some halocarbons are also strong greenhouse gases and are linked to stratospheric ozone depletion. Hydrocarbons and monoterpenes are precursors and contributors to atmospheric photochemical processes, which lead to the formation of particulates and secondary photo-oxidants such as ozone, leading to photochemical smog...
April 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29491031/state-dependent-judgement-bias-in-drosophila-evidence-for-evolutionarily-primitive-affective-processes
#20
Amanda Deakin, Michael Mendl, William J Browne, Elizabeth S Paul, James J L Hodge
Affective states influence decision-making under ambiguity in humans and other animals. Individuals in a negative state tend to interpret ambiguous cues more negatively than individuals in a positive state. We demonstrate that the fruit fly, Drosophila melanogaster , also exhibits state-dependent changes in cue interpretation. Drosophila were trained on a Go/Go task to approach a positive (P) odour associated with a sugar reward and actively avoid a negative (N) odour associated with shock. Trained flies were then either shaken to induce a purported negative state or left undisturbed (control), and given a choice between: air or P; air or N; air or ambiguous odour (1 : 1 blend of P : N)...
February 2018: Biology Letters
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