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https://www.readbyqxmd.com/read/27906454/immunotherapy-of-head-and-neck-cancer-emerging-clinical-trials-from-a-national-cancer-institute-head-and-neck-cancer-steering-committee-planning-meeting
#1
Julie E Bauman, Ezra Cohen, Robert L Ferris, David J Adelstein, David M Brizel, John A Ridge, Brian O'Sullivan, Barbara A Burtness, Lisa H Butterfield, William E Carson, Mary L Disis, Bernard A Fox, Thomas F Gajewski, Maura L Gillison, James W Hodge, Quynh-Thu Le, David Raben, Scott E Strome, Jean Lynn, Shakun Malik
Recent advances have permitted successful therapeutic targeting of the immune system in head and neck squamous cell carcinoma (HNSCC). These new immunotherapeutic targets and agents are being rapidly adopted by the oncologic community and hold considerable promise. The National Cancer Institute sponsored a Clinical Trials Planning Meeting to address the issue of how to further investigate the use of immunotherapy in patients with HNSCC. The goals of the meeting were to consider phase 2 or 3 trial designs primarily in 3 different patient populations: those with previously untreated, human papillomavirus-initiated oropharyngeal cancers; those with previously untreated, human papillomavirus-negative HNSCC; and those with recurrent/metastatic HNSCC...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27893426/sublethal-exposure-to-alpha-radiation-223ra-dichloride-enhances-various-carcinomas-sensitivity-to-lysis-by-antigen-specific-cytotoxic-t-lymphocytes-through-calreticulin-mediated-immunogenic-modulation
#2
Anthony S Malamas, Sofia R Gameiro, Karin M Knudson, James W Hodge
Radium-223 dichloride (Xofigo®; 223Ra) is an alpha-emitting radiopharmaceutical FDA-approved for the treatment of bone metastases in patients with advanced castration-resistant prostate cancer. It is also being examined clinically in patients with breast and lung carcinoma and patients with multiple myeloma. As with other forms of radiation, the aim of 223Ra is to reduce tumor burden by directly killing tumor cells. External beam (photon) and proton radiation have been shown to augment tumor sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes (CTLs)...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27865451/astrocytic-contributions-to-synaptic-and-learning-abnormalities-in-a-mouse-model-of-fragile-x-syndrome
#3
Jennifer L Hodges, Xinzhu Yu, Anthony Gilmore, Hannah Bennett, Michelle Tjia, James F Perna, Chia-Chien Chen, Xiang Li, Ju Lu, Yi Zuo
BACKGROUND: Fragile X syndrome (FXS) is the most common type of mental retardation attributable to a single-gene mutation. It is caused by FMR1 gene silencing and the consequent loss of its protein product, fragile X mental retardation protein. Fmr1 global knockout (KO) mice recapitulate many behavioral and synaptic phenotypes associated with FXS. Abundant evidence suggests that astrocytes are important contributors to neurological diseases. This study investigates astrocytic contributions to the progression of synaptic abnormalities and learning impairments associated with FXS...
September 13, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27861156/an-nk-cell-line-hank-expressing-high-levels-of-granzyme-and-engineered-to-express-the-high-affinity-cd16-allele
#4
Caroline Jochems, James W Hodge, Massimo Fantini, Rika Fujii, Y Maurice Morillon Ii, John W Greiner, Michelle R Padget, Sarah R Tritsch, Kwong Yok Tsang, Kerry S Campbell, Hans Klingemann, Laurent Boissel, Shahrooz Rabizadeh, Patrick Soon-Shiong, Jeffrey Schlom
Natural killer (NK) cells are known to play a role in mediating innate immunity, in enhancing adaptive immune responses, and have been implicated in mediating anti-tumor responses via antibody-dependent cell-mediated cytotoxicity (ADCC) by reactivity of CD16 with the Fc region of human IgG1 antibodies. The NK-92 cell line, derived from a lymphoma patient, has previously been well characterized and adoptive transfer of irradiated NK-92 cells has demonstrated safety and shown preliminary evidence of clinical benefit in cancer patients...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27821737/quasimodo-mediates-daily-and-acute-light-effects-on-drosophila-clock-neuron-excitability
#5
Edgar Buhl, Adam Bradlaugh, Maite Ogueta, Ko-Fan Chen, Ralf Stanewsky, James J L Hodge
We have characterized a light-input pathway regulating Drosophila clock neuron excitability. The molecular clock drives rhythmic electrical excitability of clock neurons, and we show that the recently discovered light-input factor Quasimodo (Qsm) regulates this variation, presumably via an Na(+), K(+), Cl(-) cotransporter (NKCC) and the Shaw K(+) channel (dKV3.1). Because of light-dependent degradation of the clock protein Timeless (Tim), constant illumination (LL) leads to a breakdown of molecular and behavioral rhythms...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27718512/feasibility-and-tolerability-of-low-intensity-whole-body-vibration-and-its-effects-on-muscle-function-and-bone-in-patients-with-dystrophinopathies-a-pilot-study
#6
Anna Petryk, Lynda E Polgreen, Molly Grames, Dawn A Lowe, James S Hodges, Peter Karachunski
INTRODUCTION: Dystrophinopathies are X-linked muscle degenerative disorders that result in progressive muscle weakness complicated by bone loss. This study's goal was to evaluate feasibility and tolerability of whole body low intensity vibration (WBLIV) and its potential effects on muscle and bone in patients with Duchenne or Becker muscular dystrophy. METHODS: This 12-month pilot study included 5 patients (age 5.9-21.7 years) who used a low-intensity Marodyne LivMD plate vibrating at 30-90 Hz for 10 minutes/day for the first 6 months...
October 8, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27716622/near-infrared-photoimmunotherapy-with-avelumab-an-anti-programmed-death-ligand-1-pd-l1-antibody
#7
Tadanobu Nagaya, Yuko Nakamura, Kazuhide Sato, Toshiko Harada, Peter L Choyke, James W Hodge, Jeffrey Schlom, Hisataka Kobayashi
Near Infrared-Photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photo-absorber conjugate (APC). Programmed cell death protein-1 ligand (PD-L1) is emerging as a molecular target. Here, we describe the efficacy of NIR-PIT, using fully human IgG1 anti-PD-L1 monoclonal antibody (mAb), avelumab, conjugated to the photo-absorber, IR700DX, in a PD-L1 expressing H441 cell line, papillary adenocarcinoma of lung. Avelumab-IR700 showed specific binding and cell-specific killing was observed after exposure of the cells to NIR in vitro...
October 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27702896/mutational-landscape-of-egfr-myc-and-kras-driven-genetically-engineered-mouse-models-of-lung-adenocarcinoma
#8
David G McFadden, Katerina Politi, Arjun Bhutkar, Frances K Chen, Xiaoling Song, Mono Pirun, Philip M Santiago, Caroline Kim-Kiselak, James T Platt, Emily Lee, Emily Hodges, Adam P Rosebrock, Roderick T Bronson, Nicholas D Socci, Gregory J Hannon, Tyler Jacks, Harold Varmus
Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to assess putative driver mutations identified by large-scale sequencing of human cancer genomes. To accurately interpret experiments that introduce additional mutations, an understanding of the somatic genetic profile and evolution of GEMM tumors is necessary. Here, we performed whole-exome sequencing of tumors from three GEMMs of lung adenocarcinoma driven by mutant epidermal growth factor receptor (EGFR), mutant Kirsten rat sarcoma viral oncogene homolog (Kras), or overexpression of MYC proto-oncogene...
October 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27676336/zika-virus-and-global-health-security
#9
Lawrence O Gostin, James G Hodge
No abstract text is available yet for this article.
October 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27643615/unmethylated-insulin-dna-is-elevated-after-total-pancreatectomy-with-islet-autotransplant-assessment-of-a-novel-beta-cell-marker
#10
Melena D Bellin, Pamela Clark, Sahar Usmani-Brown, Ty B Dunn, Gregory J Beilman, Srinath Chinnakotla, Timothy L Pruett, Peggy Ptacek, Bernhard J Hering, Zuoheng Wang, Thomas Gilmore, Joshua Wilhelm, James S Hodges, Antoinette Moran, Kevan C Herold
Beta cell death may occur both after islet isolation and during infusion back into recipients undergoing total pancreatectomy with islet autotransplantation (TPIAT) for chronic pancreatitis. We measured the novel beta cell death marker unmethylated insulin (INS) DNA in TPIAT recipients before and immediately after islet infusion (n=21), and again 90 days post-TPIAT concurrent with metabolic functional assessments (n=25). As expected, INS DNA decreased after pancreatectomy (p=0.0002). Following islet infusion, all TPIAT recipients had an elevated unmethylated INS DNA ratio in the first hours...
September 19, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27581451/a-neural-network-underlying-circadian-entrainment-and-photoperiodic-adjustment-of-sleep-and-activity-in-drosophila
#11
Matthias Schlichting, Pamela Menegazzi, Katharine R Lelito, Zepeng Yao, Edgar Buhl, Elena Dalla Benetta, Andrew Bahle, Jennifer Denike, James John Hodge, Charlotte Helfrich-Förster, Orie Thomas Shafer
UNLABELLED: A sensitivity of the circadian clock to light/dark cycles ensures that biological rhythms maintain optimal phase relationships with the external day. In animals, the circadian clock neuron network (CCNN) driving sleep/activity rhythms receives light input from multiple photoreceptors, but how these photoreceptors modulate CCNN components is not well understood. Here we show that the Hofbauer-Buchner eyelets differentially modulate two classes of ventral lateral neurons (LNvs) within the Drosophila CCNN...
August 31, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27531942/the-promise-and-pitfalls-of-public-health-policy-surveillance
#12
James G Hodge
Though public health policy surveillance is an integral tool in correlating the law to scientifically based public health law studies, drawing accurate legal conclusions from collected data can be challenging. Data may be of poor quality, inaccessible to law and policy makers, or inapplicable to other jurisdictions over time and place. As Burris et al. (2016) advocate, modern, sophisticated, and interactive data collection systems would render more precise legal analysis tied to public health improvements. Although policy surveillance is promising, public health officials, health care providers, attorneys, and researchers must be skilled and prepared to successfully navigate and resolve potential pitfalls for its benefits to be fully realized...
August 16, 2016: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/27489873/expanding-the-phenotypic-associations-of-globular-glial-tau-subtypes
#13
James R Burrell, Shelley Forrest, Thomas H Bak, John R Hodges, Glenda M Halliday, Jillian J Kril
INTRODUCTION: Clinicopathologic correlation in non-Alzheimer's tauopathies is variable, despite refinement of pathologic diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathologic correlation. METHODS: Confirmed GGT cases (n = 11) were identified from 181 frontotemporal tauopathy cases. Clinical and neuroimaging details were collected, and cases sub-typed according to the consensus criteria for GGT diagnosis...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27474916/the-neural-correlates-of-auditory-and-visuospatial-span-in-logopenic-progressive-aphasia-and-alzheimer-s-disease
#14
David Foxe, Cristian E Leyton, John R Hodges, James R Burrell, Muireann Irish, Olivier Piguet
INTRODUCTION: Logopenic progressive aphasia (lv-PPA) is a form of primary progressive aphasia and is predominantly associated with Alzheimer's disease (AD) pathology. The neuropsychological profiles of lv-PPA and typical clinical AD are, however, distinct. In particular, these two syndromes differ on attention span measures, where auditory attention span is more impaired in lv-PPA than in AD and visuospatial span appears more impaired in AD than in lv-PPA. The neural basis of these span profiles, however, remains unclear...
October 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27459721/sitagliptin-treatment-after-total-pancreatectomy-with-islet-autotransplantation-a-randomized-placebo-controlled-study
#15
Melena D Bellin, Greg J Beilman, Ty B Dunn, Timothy L Pruett, David E R Sutherland, Srinath Chinnakotla, James S Hodges, Audrey Lane, Peggy Ptacek, K Louise Berry, Bernhard J Hering, Antoinette Moran
Insulin independence after total pancreatectomy and islet autotransplant (TPIAT) for chronic pancreatitis is limited by a high rate of post-procedure beta cell apoptosis. Endogenous GLP-1 and GIP, which are increased by DPP-4 inhibitor therapy (sitagliptin) may protect against beta cell apoptosis. To determine the effect of sitgalitpin after TPIAT, 83 adult TPIAT recipients were randomized to receive sitagliptin (n=54) or placebo (n=29) for 12 months after TPIAT. At 12 and 18 months after TPIAT, participants were assessed for insulin independence; metabolic testing was performed with mixed meal tolerance testing (MMTT) and frequent sample intravenous glucose tolerance testing (FSIVGTT)...
July 26, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27410229/a-screen-peck-task-for-investigating-cognitive-bias-in-laying-hens
#16
Amanda Deakin, William J Browne, James J L Hodge, Elizabeth S Paul, Michael Mendl
Affect-induced cognitive judgement biases occur in both humans and animals. Animals in a more negative affective state tend to interpret ambiguous cues more negatively than animals in a more positive state and vice versa. Investigating animals' responses to ambiguous cues can therefore be used as a proxy measure of affective state. We investigated laying hens' responses to ambiguous stimuli using a novel cognitive bias task. In the 'screen-peck' task, hens were trained to peck a high/low saturation orange circle presented on a computer screen (positive cue-P) to obtain a mealworm reward, and to not peck when the oppositely saturated orange circle was presented (negative cue-N) to avoid a one second air puff...
2016: PloS One
https://www.readbyqxmd.com/read/27402895/motor-cortical-function-determines-prognosis-in-sporadic-als
#17
Kazumoto Shibuya, Susanna B Park, Nimeshan Geevasinga, Parvathi Menon, James Howells, Neil G Simon, William Huynh, Yu-Ichi Noto, Jürgen Götz, Jillian J Kril, Lars M Ittner, John Hodges, Glenda Halliday, Steve Vucic, Matthew C Kiernan
OBJECTIVE: To study the relationship between cortical function and survival in amyotrophic lateral sclerosis (ALS). METHODS: A total of 216 referrals were screened, and participants with familial ALS or an inexcitable cortex were excluded. Clinical measures and phenotyping from 169 patients with sporadic ALS were combined with an assessment of cortical function using threshold tracking transcranial magnetic stimulation with indices including short interval intracortical inhibition (SICI)...
August 2, 2016: Neurology
https://www.readbyqxmd.com/read/27387287/systematic-evaluation-of-industrial-commercial-and-institutional-food-waste-management-strategies-in-the-united-states
#18
Keith L Hodge, James W Levis, Joseph F DeCarolis, Morton A Barlaz
New regulations and targets limiting the disposal of food waste have been recently enacted in numerous jurisdictions. This analysis evaluated selected environmental implications of food waste management policies using life-cycle assessment. Scenarios were developed to evaluate management alternatives applicable to the waste discarded at facilities where food waste is a large component of the waste (e.g., restaurants, grocery stores, and food processors). Options considered include anaerobic digestion (AD), aerobic composting, waste-to-energy combustion (WTE), and landfilling, and multiple performance levels were considered for each option...
August 16, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27367378/properties-of-the-binary-black-hole-merger-gw150914
#19
B P Abbott, R Abbott, T D Abbott, M R Abernathy, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, B Allen, A Allocca, P A Altin, S B Anderson, W G Anderson, K Arai, M C Araya, C C Arceneaux, J S Areeda, N Arnaud, K G Arun, S Ascenzi, G Ashton, M Ast, S M Aston, P Astone, P Aufmuth, C Aulbert, S Babak, P Bacon, M K M Bader, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, J C Barayoga, S E Barclay, B C Barish, D Barker, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, I Bartos, R Bassiri, A Basti, J C Batch, C Baune, V Bavigadda, M Bazzan, B Behnke, M Bejger, A S Bell, C J Bell, B K Berger, J Bergman, G Bergmann, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, J Birch, R Birney, O Birnholtz, S Biscans, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, T P Bodiya, M Boer, G Bogaert, C Bogan, A Bohe, P Bojtos, C Bond, F Bondu, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, V B Braginsky, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, A F Brooks, D A Brown, D D Brown, N M Brown, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T Callister, E Calloni, J B Camp, K C Cannon, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, L Cerboni Baiardi, G Cerretani, E Cesarini, R Chakraborty, T Chalermsongsak, S J Chamberlin, M Chan, S Chao, P Charlton, E Chassande-Mottin, H Y Chen, Y Chen, C Cheng, A Chincarini, A Chiummo, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, S Chua, S Chung, G Ciani, F Clara, J A Clark, F Cleva, E Coccia, P-F Cohadon, A Colla, C G Collette, L Cominsky, M Constancio, A Conte, L Conti, D Cook, T R Corbitt, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, K Craig, J D E Creighton, J Cripe, S G Crowder, A Cumming, L Cunningham, E Cuoco, T Dal Canton, S L Danilishin, S D'Antonio, K Danzmann, N S Darman, V Dattilo, I Dave, H P Daveloza, M Davier, G S Davies, E J Daw, R Day, D DeBra, G Debreczeni, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, T Denker, T Dent, H Dereli, V Dergachev, R De Rosa, R T DeRosa, R DeSalvo, C Devine, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, A Di Lieto, S Di Pace, I Di Palma, A Di Virgilio, G Dojcinoski, V Dolique, F Donovan, K L Dooley, S Doravari, R Douglas, T P Downes, M Drago, R W P Drever, J C Driggers, Z Du, M Ducrot, S E Dwyer, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, W Engels, R C Essick, Z Etienne, T Etzel, M Evans, T M Evans, R Everett, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, Q Fang, S Farinon, B Farr, W M Farr, E Fauchon-Jones, M Favata, M Fays, H Fehrmann, M M Fejer, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, I Fiori, D Fiorucci, R P Fisher, R Flaminio, M Fletcher, J-D Fournier, S Franco, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, T T Fricke, P Fritschel, V V Frolov, P Fulda, M Fyffe, H A G Gabbard, S M Gaebel, J R Gair, L Gammaitoni, S G Gaonkar, F Garufi, A Gatto, G Gaur, N Gehrels, G Gemme, B Gendre, E Genin, A Gennai, J George, L Gergely, V Germain, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, A Glaefke, E Goetz, R Goetz, L Gondan, G González, J M Gonzalez Castro, A Gopakumar, N A Gordon, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, C Graef, P B Graff, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, P Groot, H Grote, S Grunewald, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, J J Hacker, B R Hall, E D Hall, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, M T Hartman, C-J Haster, K Haughian, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, A W Heptonstall, M Heurs, S Hild, D Hoak, K A Hodge, D Hofman, S E Hollitt, K Holt, D E Holz, P Hopkins, D J Hosken, J Hough, E A Houston, E J Howell, Y M Hu, S Huang, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, A Idrisy, N Indik, D R Ingram, R Inta, H N Isa, J-M Isac, M Isi, G Islas, T Isogai, B R Iyer, K Izumi, T Jacqmin, H Jang, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, N K Johnson-McDaniel, D I Jones, R Jones, R J G Jonker, L Ju, Haris K, C V Kalaghatgi, V Kalogera, S Kandhasamy, G Kang, J B Kanner, S Karki, M Kasprzack, E Katsavounidis, W Katzman, S Kaufer, T Kaur, K Kawabe, F Kawazoe, F Kéfélian, M S Kehl, D Keitel, D B Kelley, W Kells, R Kennedy, J S Key, A Khalaidovski, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, C Kim, J Kim, K Kim, Nam-Gyu Kim, Namjun Kim, Y-M Kim, E J King, P J King, D L Kinzel, J S Kissel, L Kleybolte, S Klimenko, S M Koehlenbeck, K Kokeyama, S Koley, V Kondrashov, A Kontos, M Korobko, W Z Korth, I Kowalska, D B Kozak, V Kringel, B Krishnan, A Królak, C Krueger, G Kuehn, P Kumar, L Kuo, A Kutynia, B D Lackey, M Landry, J Lange, B Lantz, P D Lasky, A Lazzarini, C Lazzaro, P Leaci, S Leavey, E O Lebigot, C H Lee, H K Lee, H M Lee, K Lee, A Lenon, M Leonardi, J R Leong, N Leroy, N Letendre, Y Levin, B M Levine, T G F Li, A Libson, T B Littenberg, N A Lockerbie, J Logue, A L Lombardi, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, A P Lundgren, J Luo, R Lynch, Y Ma, T MacDonald, B Machenschalk, M MacInnis, D M Macleod, F Magaña-Sandoval, R M Magee, M Mageswaran, E Majorana, I Maksimovic, V Malvezzi, N Man, I Mandel, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, F Marchesoni, F Marion, S Márka, Z Márka, A S Markosyan, E Maros, F Martelli, L Martellini, I W Martin, R M Martin, D V Martynov, J N Marx, K Mason, A Masserot, T J Massinger, M Masso-Reid, F Matichard, L Matone, N Mavalvala, N Mazumder, G Mazzolo, R McCarthy, D E McClelland, S McCormick, S C McGuire, G McIntyre, J McIver, D J McManus, S T McWilliams, D Meacher, G D Meadors, J Meidam, A Melatos, G Mendell, D Mendoza-Gandara, R A Mercer, E Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, P M Meyers, F Mezzani, H Miao, C Michel, H Middleton, E E Mikhailov, L Milano, J Miller, M Millhouse, Y Minenkov, J Ming, S Mirshekari, C Mishra, S Mitra, V P Mitrofanov, G Mitselmakher, R Mittleman, A Moggi, M Mohan, S R P Mohapatra, M Montani, B C Moore, C J Moore, D Moraru, G Moreno, S R Morriss, K Mossavi, B Mours, C M Mow-Lowry, C L Mueller, G Mueller, A W Muir, Arunava Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, D J Murphy, P G Murray, A Mytidis, I Nardecchia, L Naticchioni, R K Nayak, V Necula, K Nedkova, G Nelemans, M Neri, A Neunzert, G Newton, T T Nguyen, A B Nielsen, S Nissanke, A Nitz, F Nocera, D Nolting, M E Normandin, L K Nuttall, J Oberling, E Ochsner, J O'Dell, E Oelker, G H Ogin, J J Oh, S H Oh, F Ohme, M Oliver, P Oppermann, Richard J Oram, B O'Reilly, R O'Shaughnessy, D J Ottaway, R S Ottens, H Overmier, B J Owen, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, H Pan, Y Pan, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, H R Paris, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, B Patricelli, Z Patrick, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, S Penn, A Perreca, H P Pfeiffer, M Phelps, O Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pitkin, R Poggiani, P Popolizio, A Post, J Powell, J Prasad, V Predoi, S S Premachandra, T Prestegard, L R Price, M Prijatelj, M Principe, S Privitera, G A Prodi, L Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, J Qin, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, M Rakhmanov, P Rapagnani, V Raymond, M Razzano, V Re, J Read, C M Reed, T Regimbau, L Rei, S Reid, D H Reitze, H Rew, S D Reyes, F Ricci, K Riles, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, R Romano, G Romanov, J H Romie, D Rosińska, C Röver, S Rowan, A Rüdiger, P Ruggi, K Ryan, S Sachdev, T Sadecki, L Sadeghian, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, E J Sanchez, V Sandberg, B Sandeen, J R Sanders, B Sassolas, B S Sathyaprakash, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, R Schilling, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B F Schutz, J Scott, S M Scott, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, G Serna, Y Setyawati, A Sevigny, D A Shaddock, S Shah, M S Shahriar, M Shaltev, Z Shao, B Shapiro, P Shawhan, A Sheperd, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, D Sigg, A D Silva, D Simakov, A Singer, L P Singer, A Singh, R Singh, A Singhal, A M Sintes, B J J Slagmolen, J R Smith, N D Smith, R J E Smith, E J Son, B Sorazu, F Sorrentino, T Souradeep, A K Srivastava, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, B C Stephens, S P Stevenson, R Stone, K A Strain, N Straniero, G Stratta, N A Strauss, S Strigin, R Sturani, A L Stuver, T Z Summerscales, L Sun, P J Sutton, B L Swinkels, M J Szczepańczyk, M Tacca, D Talukder, D B Tanner, M Tápai, S P Tarabrin, A Taracchini, R Taylor, T Theeg, M P Thirugnanasambandam, E G Thomas, M Thomas, P Thomas, K A Thorne, K S Thorne, E Thrane, S Tiwari, V Tiwari, K V Tokmakov, C Tomlinson, M Tonelli, C V Torres, C I Torrie, D Töyrä, F Travasso, G Traylor, D Trifirò, M C Tringali, L Trozzo, M Tse, M Turconi, D Tuyenbayev, D Ugolini, C S Unnikrishnan, A L Urban, S A Usman, H Vahlbruch, G Vajente, G Valdes, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, M V van der Sluys, J V van Heijningen, A Vañó-Viñuales, A A van Veggel, M Vardaro, S Vass, M Vasúth, R Vaulin, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, D Verkindt, F Vetrano, A Viceré, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, D Voss, W D Vousden, S P Vyatchanin, A R Wade, L E Wade, M Wade, M Walker, L Wallace, S Walsh, G Wang, H Wang, M Wang, X Wang, Y Wang, R L Ward, J Warner, M Was, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, T Welborn, L Wen, P Weßels, T Westphal, K Wette, J T Whelan, D J White, B F Whiting, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Worden, J L Wright, G Wu, J Yablon, W Yam, H Yamamoto, C C Yancey, M J Yap, H Yu, M Yvert, A Zadrożny, L Zangrando, M Zanolin, J-P Zendri, M Zevin, F Zhang, L Zhang, M Zhang, Y Zhang, C Zhao, M Zhou, Z Zhou, X J Zhu, M E Zucker, S E Zuraw, J Zweizig, M Boyle, B Brügmann, M Campanelli, M Clark, D Hamberger, L E Kidder, M Kinsey, P Laguna, S Ossokine, M A Scheel, B Szilagyi, S Teukolsky, Y Zlochower
On September 14, 2015, the Laser Interferometer Gravitational-Wave Observatory (LIGO) detected a gravitational-wave transient (GW150914); we characterize the properties of the source and its parameters. The data around the time of the event were analyzed coherently across the LIGO network using a suite of accurate waveform models that describe gravitational waves from a compact binary system in general relativity. GW150914 was produced by a nearly equal mass binary black hole of masses 36_{-4}^{+5}M_{⊙} and 29_{-4}^{+4}M_{⊙}; for each parameter we report the median value and the range of the 90% credible interval...
June 17, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27362933/legal-preemption-and-the-prevention-of-chronic-conditions
#20
James G Hodge, Alicia Corbett
State and local legal innovations to address chronic conditions are an ongoing source of public health improvements. For decades, some of the most ingenious law and policy ideas to address the underlying causes of chronic conditions and their contributing factors have emerged from state or local public sector grassroots initiatives in diverse areas, including tobacco use, safe housing and transportation, and environmental hazards. These reforms, however, are susceptible to invalidation through the legal doctrine of preemption...
2016: Preventing Chronic Disease
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