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methamphetamine induced psychosis

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https://www.readbyqxmd.com/read/27753212/methamphetamine-induced-psychosis-is-associated-with-dna-hypomethylation-and-increased-expression-of-akt1-and-key-dopaminergic-genes
#1
Shabnam Nohesara, Mohammad Ghadirivasfi, Mahmood Barati, Mohammad-Reza Ghasemzadeh, Samira Narimani, Zohreh Mousavi-Behbahani, Mohammadtaghi Joghataei, Mansoureh Soleimani, Mozhgan Taban, Soraya Mehrabi, Sam Thiagalingam, Hamid Mostafavi Abdolmaleky
Methamphetamine, one of the most frequently used illicit drugs worldwide, can induce psychosis in a large fraction of abusers and it is becoming a major problem for the health care institutions. There is some evidence that genetic and epigenetic factors may play roles in methamphetamine psychosis. In this study, we examined methamphetamine-induced epigenetic and expression changes of several key genes involved in psychosis. RNA and DNA extracted from the saliva samples of patients with methamphetamine dependency with and without psychosis as well as control subjects (each group 25) were analyzed for expression and promoter DNA methylation status of DRD1, DRD2, DRD3, DRD4, MB-COMT, GAD1, and AKT1 using qRT-PCR and q-MSP, respectively...
December 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27599617/polysubstance-induced-relapse-of-schizoaffective-disorder-refractory-to-high-dose-antipsychotic-medications-a-case-report
#2
Murray G Tucker, Sebastian Kekulawala, Michelle Kent, Sam Mostafa, Richard Harvey
BACKGROUND: The high prevalence of comorbid illicit drug use in persons with chronic psychotic illness represents a strong determinant of psychotic relapse and rehospitalization. Epidemiological studies indicate changing patterns of illicit drug use in Australia, which are concerning because of increased use of crystal methamphetamine, also known as "ice." An important complication of habitual use of crystal methamphetamine is the development of a dose-dependent acute psychotic reaction...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27580848/gabaergic-mrna-expression-is-differentially-expressed-across-the-prelimbic-and-orbitofrontal-cortices-of-rats-sensitized-to-methamphetamine-relevance-to-psychosis
#3
Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornish
Psychotic disorders, such as schizophrenia, are characterized by prevalent and persistent executive deficits that are believed to be the result of dysfunctional inhibitory gamma-aminobutyric acid (GABA) processing of the prefrontal cortex (PFC). Methamphetamine (METH) is a commonly used psychostimulant that can induce psychotic and cognitive symptoms that are indistinguishable to schizophrenia, suggesting that METH-induced psychosis may have a similar GABAergic profile of the PFC. As the PFC consists of multiple subregions, the aim of the current study was to investigate changes to GABAergic mRNA expression in the prelimbic (PRL) and orbitofrontal (OFC) cortices of the PFC in rats sensitized to repeated METH administration...
December 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27499362/subcortical-grey-matter-alterations-in-cocaine-dependent-individuals-with-substance-induced-psychosis-compared-to-non-psychotic-cocaine-users
#4
Taylor S Willi, Donna J Lang, William G Honer, Geoff N Smith, Allen E Thornton, William J Panenka, Ric M Procyshyn, Fidel Vila-Rodriguez, Wayne Su, A Talia Vertinsky, Olga Leonova, Alexander Rauscher, G William MacEwan, Alasdair M Barr
After prolonged psychostimulant abuse, transient psychotic symptoms referred to as "substance-induced psychosis" (SIP) can develop - closely resembling symptoms observed in schizophrenia spectrum disorders. The comparability in psychotic presentation between SIP and schizophrenias suggests that similar underlying neural deficits may contribute to the expression of psychosis across these disorders. To date, neuroanatomical characterization of grey matter structural alterations in SIP has been limited to methamphetamine associated psychosis, with no studies controlling for potential neurotoxic effects of the psychostimulant that precipitates psychosis...
October 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27267861/dual-effects-of-limbic-seizures-on-psychosis-relevant-behaviors-shown-by-nucleus-accumbens-kindling-in-rats
#5
Jingyi Ma, L Stan Leung
BACKGROUND: A paradox in epilepsy and psychiatry is that temporal lobe epilepsy is often predisposed to schizophrenic-like psychosis, whereas convulsive therapy can relieve schizophrenic symptoms. We have previously demonstrated that the nucleus accumbens is a key structure in mediating postictal psychosis induced by a hippocampal electrographic seizure. OBJECTIVE/HYPOTHESIS: The purpose of this study is to test a hypothesis that accumbens kindling cumulating in a single (1-time) or repeated (5-times) convulsive seizures have different effects on animal models of psychosis...
September 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27179799/effect-of-methamphetamine-exposure-on-expression-of-calcium-binding-proteins-in-rat-frontal-cortex-and-hippocampus
#6
Siriluk Veerasakul, Samur Thanoi, Gavin P Reynolds, Sutisa Nudmamud-Thanoi
Methamphetamine (METH) is a psychostimulant drug with potent effects on the central nervous system that can cause psychotic symptoms similar to those of schizophrenia. Specific alterations in GABAergic neuronal markers have been reported in schizophrenia and animal models of psychotic illness. The aim of this study was to determine whether there are changes in subpopulations of GABAergic neurons, defined by the presence of calcium binding proteins (CBPs), in animal models of METH abuse. Rats received acute (Binge) doses of 4 × 6 mg/kg, a chronic escalating dose regime (0...
October 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27175554/psychosis-induced-by-amphetamines
#7
Jrgen G Bramness, Eline B Rognli
PURPOSE OF REVIEW: The study reviews publications on the use of methamphetamine and amphetamine in relation to psychotic symptoms, substance-induced psychosis, and primary psychosis published between July 2014 and December 2015. The databases MEDLINE, Embase, and PsycINFO were searched using the terms 'amphetamine psychosis' and 'methamphetamine psychosis' for the time period 1 July 2014 to 31 December 2015. RECENT FINDINGS: There were 37 studies published on the subject during this time period...
July 2016: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/27172885/demographic-and-mental-history-related-data-predicted-occurrence-of-psychosis-in-metamphetamine-users
#8
Vahid Farnia, Jalal Shakeri, Faezeh Tatari, Toraj Ahmadi Juibari, Hafez Bajoghli, Senoobar Golshani, Sara Hookari, Edith Holsboer-Trachsler, Serge Brand
Methamphetamine use is increasing worldwide, and the occurrence of psychosis further complicates treatment. This holds also true for Iran. The aim of the present study was to investigate possible predictors of metamphetamine-induced psychosis. 237 methamphetamine users (70.9% with psychosis; mean age: M=33.41 years) took part in the study. A psychiatric interview was performed covering socio-demographic and illness-related information. Male gender, low education, unemployment, being single, a history of mental disorders, and a higher number of previous hospitalizations predicted the occurrence of psychosis, while age and duration of metamphetamine use were excluded from the equation...
June 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27085900/dopamine-dynamics-during-emotional-cognitive-processing-implications-of-the-specific-actions-of-clozapine-compared-with-haloperidol
#9
Masahiko Kawano, Hidehiro Oshibuchi, Takaaki Kawano, Hiroyuki Muraoka, Takahiro Tsutsumi, Makiko Yamada, Ken Inada, Jun Ishigooka
Clozapine has improved efficacy relative to typical antipsychotics in schizophrenia treatment, particularly regarding emotional symptoms. However, the mechanisms underlying its therapeutic benefits remain unclear. Using a methamphetamine-sensitised rat model, we measured changes in dopamine levels in the amygdalae in response to a fear-conditioned cue, serving as a biochemical marker of emotional cognitive processing disruption in psychosis, for analysing the biochemical mechanisms associated with the clinical benefits of clozapine...
June 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27050450/reduced-prefrontal-cortex-hemodynamic-response-in-adults-with-methamphetamine-induced-psychosis-relevance-for-impulsivity
#10
Kazuhiko Yamamuro, Sohei Kimoto, Junzo Iida, Naoko Kishimoto, Yoko Nakanishi, Shohei Tanaka, Toyosaku Ota, Manabu Makinodan, Toshifumi Kishimoto
Patients with methamphetamine abuse/dependence often exhibit high levels of impulsivity, which may be associated with the structural abnormalities and functional hypoactivities observed in the frontal cortex of these subjects. Although near-infrared spectroscopy (NIRS) is a simple and non-invasive method for characterizing the clinical features of various psychiatric illnesses, few studies have used NIRS to directly investigate the association between prefrontal cortical activity and inhibitory control in patients with methamphetamine-induced psychosis (MAP)...
2016: PloS One
https://www.readbyqxmd.com/read/26992824/brain-site-and-transmitter-dependent-actions-of-methamphetamine-morphine-and-antipsychotics
#11
Tomohisa Mori, Yoshiyuki Iwase, Asami Murata, Noriyuki Iwata, Tsutomu Suzuki
While several methamphetamine- and morphine-induced psychotic states are ordinarily treated by antipsychotics, the therapeutic mechanisms of antipsychotic drugs have yet been elucidated. The present study was designed to investigate the mechanisms how antipsychotic drugs suppress the behavioral changes induced by psychoactive drugs in mice. Low to medium doses of methamphetamine produced hyperlocomotion, whereas high dose of methamphetamine induced hypolocomotion. Hyperlocomotion induced by methamphetamine was potently suppressed by clozapine and 5-HT2 receptor antagonists, but not by the intra-accumbens injection of haloperidol...
June 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26911516/clinical-features-course-and-treatment-of-methamphetamine-induced-psychosis-in-psychiatric-inpatients
#12
Homa Zarrabi, Mohammadrasoul Khalkhali, Azam Hamidi, Reza Ahmadi, Maryam Zavarmousavi
BACKGROUND: Over the past few years, methamphetamine-induced psychosis (MIP) has increased in Iran, accounting for a significant percentage of psychiatry hospital admissions. The present study was conducted with an aim to investigate clinical symptoms, and course and treatment methods of MIP inpatients in Shafa Psychiatry Hospital in northern Iran. METHODS: Participants were 152 MIP inpatients. Brief Psychiatric Rating Scale (BPRS) subscales of suspiciousness, unusual thought content; hallucinations and hostility were used to measure psychiatric symptoms...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/26874915/the-profile-of-psychiatric-symptoms-exacerbated-by-methamphetamine-use
#13
Rebecca McKetin, Sharon Dawe, Richard A Burns, Leanne Hides, David J Kavanagh, Maree Teesson, Ross McD Young, Alexandra Voce, John B Saunders
BACKGROUND: Methamphetamine use can produce symptoms almost indistinguishable from schizophrenia. Distinguishing between the two conditions has been hampered by the lack of a validated symptom profile for methamphetamine-induced psychiatric symptoms. We use data from a longitudinal cohort study to examine the profile of psychiatric symptoms that are acutely exacerbated by methamphetamine use. METHODS: 164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale...
April 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/26864947/changes-of-sperm-quality-and-hormone-receptors-in-the-rat-testis-after-exposure-to-methamphetamine
#14
Sutisa Nudmamud-Thanoi, Wanvipa Sueudom, Nareelak Tangsrisakda, Samur Thanoi
Methamphetamine (METH) is known to damage neurons and induce psychosis. It can also induce apoptosis in seminiferous tubules and affect sperm quality. The present study was carried out to investigate the effect of a rat model of METH addiction on sperm quality and expression of progesterone receptors (PR) and estrogen receptors (ER) in the testis. Sperm quality parameters including sperm motility, sperm morphology and sperm concentration were examined. Protein and gene expressions PR, ERα and ERβ were studied using immunohistochemistry and reverse transcriptase-polymerase chain reaction, respectively...
October 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/26581673/the-long-term-effects-of-methamphetamine-exposure-during-pre-adolescence-on-depressive-like-behaviour-in-a-genetic-animal-model-of-depression
#15
Moné Mouton, Brian H Harvey, Marike Cockeran, Christiaan B Brink
Methamphetamine (METH) is a psychostimulant and drug of abuse, commonly used early in life, including in childhood and adolescence. Adverse effects include psychosis, anxiety and mood disorders, as well as increased risk of developing a mental disorder later in life. The current study investigated the long-term effects of chronic METH exposure during pre-adolescence in stress-sensitive Flinders Sensitive Line (FSL) rats (genetic model of depression) and control Flinders Resistant Line (FRL) rats. METH or vehicle control was administered twice daily from post-natal day 19 (PostND19) to PostND34, followed by behavioural testing at either PostND35 (early effects) or long-lasting after withdrawal at PostND60 (early adulthood)...
February 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/26475507/gabaergic-mrna-expression-is-upregulated-in-the-prefrontal-cortex-of-rats-sensitized-to-methamphetamine
#16
Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornish
Inhibitory gamma-aminobutyric acid (GABA)-mediated neurotransmission plays an important role in the regulation of the prefrontal cortex (PFC), with increasing evidence suggesting that dysfunctional GABAergic processing of the PFC may underlie certain deficits reported across psychotic disorders. Methamphetamine (METH) is a psychostimulant that induces chronic psychosis in a subset of users, with repeat administration producing a progressively increased vulnerability to psychotic relapse following subsequent drug administration (sensitization)...
January 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26453694/bdnf-deficient-mice-show-reduced-psychosis-related-behaviors-following-chronic-methamphetamine
#17
Elizabeth E Manning, Adam L Halberstadt, Maarten van den Buuse
BACKGROUND: One of the most devastating consequences of methamphetamine abuse is increased risk of psychosis. Brain-derived neurotrophic factor has been implicated in both psychosis and neuronal responses to methamphetamine. We therefore examined persistent psychosis-like behavioral effects of methamphetamine in brain-derived neurotrophic factor heterozygous mice. METHODS: Mice were chronically treated with methamphetamine from 6 to 9 weeks of age, and locomotor hyperactivity to an acute D-amphetamine challenge was tested in photocell cages after a 2-week withdrawal period...
April 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26322209/a-study-of-the-prevalence-of-psychiatric-disorders-in-patients-with-methamphetamine-induced-psychosis
#18
Mahin Eslami-Shahrbabaki, Alireza Fekrat, Shahrzad Mazhari
BACKGROUND: The abuse of narcotic drugs and psychotropic substances such as amphetamines and ecstasy has had a growing trend. Tachycardia, increased blood pressure, hallucinations, panic attacks, and psychosis are the negative effects of methamphetamine abuse. The present study aimed to assess psychiatric disorders associated with methamphetamine-induced psychotic disorder. METHODS: This cross-sectional study was performed from October 2013 to March 2014 on 165 patients hospitalized at Shahid Beheshti Hospital in Kerman, Iran, and diagnosed with psychosis induced by methamphetamine abuse within the previous 6 months...
January 2015: Addiction & Health
https://www.readbyqxmd.com/read/26271595/lithium-protects-against-methamphetamine-induced-neurotoxicity-in-pc12-cells-via-akt-gsk3%C3%AE-mtor-pathway
#19
Jintao Wu, Dexiao Zhu, Jing Zhang, Guibao Li, Zengxun Liu, Jinhao Sun
Methamphetamine (MA) is neurotoxic, especially in dopaminergic neurons. Long-lasting exposure to MA causes psychosis and increases the risk of Parkinson's disease. Lithium (Li) is a known mood stabilizer and has neuroprotective effects. Previous studies suggest that MA exposure decreases the phosphorylation of Akt/GSK3β pathway in vivo, whereas Li facilitates the phosphorylation of Akt/GSK3β pathway. Moreover, GSK3β and mTOR are implicated in the locomotor sensitization induced by psychostimulants and mTOR plays a critical role in MA induced toxicity...
September 25, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26178613/differential-patterns-of-blood-oxygenation-in-the-prefrontal-cortex-between-patients-with-methamphetamine-induced-psychosis-and-schizophrenia
#20
COMPARATIVE STUDY
Kazuhiko Yamamuro, Manabu Makinodan, Sohei Kimoto, Naoko Kishimoto, Tsubasa Morimoto, Michihiro Toritsuka, Kiwamu Matsuoka, Yoshihiro Takebayashi, Tomoyo Takata, Masato Takahashi, Yoshinori Tanimura, Yosuke Nishihata, Yasuhiro Matsuda, Toyosaku Ota, Hiroki Yoshino, Junzo Iida, Toshifumi Kishimoto
Despite some slight differences in symptomatology, differential diagnosis of methamphetamine-induced psychosis (MAP) versus schizophrenia can be challenging because both disorders present a large overlap in their clinical symptoms. However, a recent study has shown that near-infrared spectroscopy (NIRS) performed during a cognitive task can be a powerful tool to differentiate between these two disorders. Here, we evaluated verbal fluency task performance during NIRS in 15 patients diagnosed with MAP and 19 with schizophrenia matched for age and sex...
2015: Scientific Reports
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