Qing Cai, Luying He, Silin Wang, Wei Chu, Lingli Zhou, Wenli Pan, Lu Zhang, Shan Jiang, Dangyang Ma, Xue Liang, Jingxin Gou, Tian Yin, Yu Zhang, Xing Tang, Haibing He
This work describes the preparation of aripiprazole sustained-release microcrystals for intramuscular injection, through recrystallization, drying, wet grinding, and solidification steps, which had a great impact on the product quality. Here, we evaluated the crystal form of the drug in each step by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and fourier transform infrared spectroscopy (FT-IR), demonstrating that there is no change in the crystal form of aripiprazole monohydrate (H1) during grinding and freeze-drying...
December 1, 2018: European Journal of Pharmaceutical Sciences