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https://www.readbyqxmd.com/read/28595931/aripiprazole-induced-adverse-metabolic-alterations-in-polyi-c-neurodevelopmental-model-of-schizophrenia-in-rats
#1
Katerina Horska, Jana Ruda-Kucerova, Eva Drazanova, Michal Karpisek, Regina Demlova, Tomas Kasparek, Hana Kotolova
Schizophrenia appears to be linked to higher incidence of metabolic syndrome even in the absence of antipsychotic treatment. Atypical antipsychotics substantially differ in their propensity to induce metabolic alterations. Aripiprazole is considered to represent an antipsychotic drug with low risk of metabolic syndrome development. The aim of this study was to evaluate metabolic phenotype of neurodevelopmental polyI:C rat model and assess metabolic effects of chronic aripiprazole treatment with regard to complex neuroendocrine regulations of energy homeostasis...
September 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28579725/cost-savings-from-an-antipsychotic-tablet-splitting-program
#2
Heather Carey, Mark Fondriest
BACKGROUND: Newer atypical antipsychotics such as aripiprazole (Abilify, Otsuka) and lurasidone (Latuda, Sunovion) have favorable safety and efficacy profiles, but their use is limited by high cost. University Hospitals Richmond Medical Center initiated an antipsychotic tablet-splitting program in August 2015 to counter the costs based on the identical pricing structure of aripiprazole and lurasidone doses. METHODS: A retrospective chart review was completed for all patients dispensed aripiprazole or lurasidone oral tablets from May 1, 2015, through December 31, 2015, to evaluate the potential cost-savings for our facility...
June 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/28536511/aripiprazole-facilitates-extinction-of-conditioned-fear-in-adolescent-rats
#3
Despina E Ganella, Liubov Lee-Kardashyan, Sophia J Luikinga, Danny L D Nguyen, Heather B Madsen, Isabel C Zbukvic, Russell Coulthard, Andrew J Lawrence, Jee Hyun Kim
Anxiety disorders are the most common type of mental disorder during adolescence, which is at least partly due to the resistance to extinction exhibited at this age. The dopaminergic system is known to be dysregulated during adolescence; therefore, we aimed to facilitate extinction in adolescent rats using the dopamine receptor 2 partial agonist aripiprazole (Abilify™), and examine the behavioral and neural outcomes. Adolescent rats were conditioned to fear a tone. The next day, rats received extinction 30 min after a systemic injection of either 5 mg/kg aripiprazole or vehicle, and then were tested the following day...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27708677/pharmacoeconomic-comparison-of-aripiprazole-once-monthly-and-paliperidone-palmitate-from-a-head-to-head-clinical-trial-in-schizophrenia-a-us-analysis
#4
Christophe Sapin, Ann Hartry, Siddhesh A Kamat, Maud Beillat, Ross A Baker, Anna Eramo
Schizophrenia presents a substantial clinical and economic burden to the health-care system. In QUAlity of LIfe with AbiliFY Maintena (QUALIFY), a randomized head-to-head study of aripiprazole once-monthly 400 mg (AOM 400) compared with paliperidone palmitate (PP; 78-234 mg/mo), AOM 400 demonstrated greater improvement in health-related quality of life and functioning in patients with stable schizophrenia. The present analysis used health economics assessment data collected during the QUALIFY study to determine the direct medical and pharmacy costs and the cost-effectiveness associated with each treatment over 6 months...
2016: Drugs in Context
https://www.readbyqxmd.com/read/26946126/role-of-dopamine-2-receptor-in-impaired-drug-cue-extinction-in-adolescent-rats
#5
Isabel C Zbukvic, Despina E Ganella, Christina J Perry, Heather B Madsen, Christopher R Bye, Andrew J Lawrence, Jee Hyun Kim
Adolescent drug users display resistance to treatment such as cue exposure therapy (CET), as well as increased liability to relapse. The basis of CET is extinction learning, which involves dopamine signaling in the medial prefrontal cortex (mPFC). This system undergoes dramatic alterations during adolescence. Therefore, we investigated extinction of a cocaine-associated cue in adolescent and adult rats. While cocaine self-administration and lever-alone extinction were not different between the two ages, we observed that cue extinction reduced cue-induced reinstatement in adult but not adolescent rats...
2016: Cerebral Cortex
https://www.readbyqxmd.com/read/26786936/clinical-effectiveness-and-patient-perspectives-of-different-treatment-strategies-for-tics-in-children-and-adolescents-with-tourette-syndrome-a-systematic-review-and-qualitative-analysis
#6
REVIEW
Chris Hollis, Mary Pennant, José Cuenca, Cris Glazebrook, Tim Kendall, Craig Whittington, Sarah Stockton, Linnéa Larsson, Penny Bunton, Suzanne Dobson, Madeleine Groom, Tammy Hedderly, Isobel Heyman, Georgina M Jackson, Stephen Jackson, Tara Murphy, Hugh Rickards, Mary Robertson, Jeremy Stern
BACKGROUND: Tourette syndrome (TS) is a neurodevelopmental condition characterised by chronic motor and vocal tics affecting up to 1% of school-age children and young people and is associated with significant distress and psychosocial impairment. OBJECTIVE: To conduct a systematic review of the benefits and risks of pharmacological, behavioural and physical interventions for tics in children and young people with TS (part 1) and to explore the experience of treatment and services from the perspective of young people with TS and their parents (part 2)...
January 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/26766033/availability-of-prescription-drugs-for-bipolar-disorder-at-online-pharmacies
#7
Scott Monteith, Tasha Glenn, Rita Bauer, Jörn Conell, Michael Bauer
BACKGROUND: There is increasing use of online pharmacies to purchase prescription drugs. While some online pharmacies are legitimate and safe, there are many unsafe and illegal so-called "rogue" online pharmacies. This study investigated the availability of psychotropic drugs online to consumers in the US, using 5 commonly prescribed drugs for bipolar disorder. METHODS: Using the search term "buy [drug name]" in the Google, Yahoo and Bing search engines, the characteristics of the online pharmacies found on the first two pages of search results were investigated...
March 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26642668/clinical-experience-of-long-term-treatment-with-aripiprazole-abilify-in-children-and-adolescents-at-the-child-and-adolescent-psychiatric-clinic-1-in-roskilde-denmark
#8
Beata Diomšina, Pernille Darling Rasmussen, Vita Danilevičiütė
The aim of this paper is to share the clinical experience of the treatment of aripiprazole (Abilify) in children and adolescents. The authors have done a cross-sectional study about Abilify's treatment in children and adolescents with severe conduct problems (high impulsivity, aggression, outward reaction, physical cross-border behavior), high restlessness with ADHD, psychotic and psychosis-like symptoms with autistic disorders, psychosis, and intensive tics with Tourette's syndrome. The authors studied and described patients at the Child and Adolescent Psychiatric Clinic 1 in Roskilde, Denmark, who were treated with Abilify and were patients of the clinic in June 2013...
May 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26289486/the-safety-efficacy-and-tolerability-of-abilify-maintena-for-the-treatment-of-schizophrenia
#9
Rene S Kahn, Amalia Giannopoulou
Relapse in schizophrenia has been associated with poor adherence to oral medication. A possible method to optimize medication adherence could be to switch patients from oral to depot medication. In this respect, aripiprazole long acting injectable (ALAI) significantly delayed time to impending relapse when compared with placebo (p < 0.0001), while ALAI was generally well tolerated during both short-term and long-term studies. A literature search, using PubMed was conducted to identify relevant publications...
2015: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/26235040/the-safety-efficacy-and-tolerability-of-abilify-maintena-for-the-treatment-of-schizophrenia
#10
Rene S Kahn, Amalia Giannopoulou
Relapse in schizophrenia has been associated with poor adherence to oral medication. A possible method to optimize medication adherence could be to switch patients from oral to depot medication. In this respect, aripiprazole long acting injectable (ALAI) significantly delayed time to impending relapse when compared with placebo (p < 0.0001), while ALAI was generally well tolerated during both short-term and long-term studies. A literature search, using PubMed was conducted to identify relevant publications...
August 2, 2015: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/25948328/development-of-gummi-drugs-of-aripiprazole-as-hospital-formulations
#11
Shinya Uchida, Shogo Hiraoka, Noriyuki Namiki
About half of patients with schizophrenia have poor adherence to taking medication, so many have recurrence, therefore, providing formulations that enable patients to continue their medication without interruption is important. We aimed to develop a gummi drug that contains aripiprazole (which can reduce schizophrenia and manic symptoms in bipolar disorder). We were able to develop gummi drugs (OD-G, PW-G and OS-G) using three commercially available aripiprazole products (Abilify® orally disintegrating tablets, powder formulation, and oral solutions, respectively) as hospital formulations...
2015: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/25763682/modular-c-h-functionalization-cascade-of-aryl-iodides
#12
Hang Shi, David J Babinski, Tobias Ritter
We report the first example of ipso-borylation for the modular 1,2-bisfunctionalization of aryl iodides via C-H functionalization. The carbon-boron bond is used as a lynchpin to access ipso carbon-carbon, carbon-nitrogen, carbon-oxygen, and carbon-halogen (Cl, Br, I) bonds. The utility of our methodology is illustrated through quick, modular syntheses of the pharmaceuticals Abilify and Flunixin.
March 25, 2015: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/25346958/atypical-antipsychotics-are-not-all-alike-side-effects-and-risk-assessment
#13
Robert H Howland
Atypical antipsychotic drugs are not all alike with respect to their pharmacologies, therapeutic uses, and side eff ects, although many clinicians lump them together and do not distinguish among them. Risk assessment for the potential use of a drug, such as aripiprazole (Abilify), should not focus on any particular adverse effect, but rather should consider risk assessment in a broader context. Specifically, what are the alternatives, and what are their inherent risk profiles? What is the risk of no treatment? Side eff ects commonly associated with a particular drug or class of drugs can also occur with other drugs...
September 2014: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/25323073/voluntary-wheel-running-ameliorates-symptoms-of-mk-801-induced-schizophrenia-in-mice
#14
Tae-Woon Kim, Hyun-Sik Kang, Joon-Ki Park, Sam-Jun Lee, Sang-Bin Baek, Chang-Ju Kim
Schizophrenia is a chronic and severe mental disorder characterized by the disintegration of cognitive thought processes and emotional responses. Despite the precise cause of schizophrenia remains unclear, it is hypothesized that a dysregulation of the N‑methyl‑D‑aspartate (NMDA) receptor in the brain is a major contributing factor to its development. Brain‑derived neurotrophic factor (BDNF) is a member of the neurotrophin family and is implicated in learning and memory processes. In the present study, we investigated in vivo the effects of voluntary wheel running on behavioral symptoms associated with NMDA receptor expression, using MK‑801‑induced schizophrenic mice...
December 2014: Molecular Medicine Reports
https://www.readbyqxmd.com/read/24969315/aripiprazole-abilify-maintena%C3%A2-a-review-of-its-use-as-maintenance-treatment-for-adult-patients-with-schizophrenia
#15
REVIEW
Matt Shirley, Caroline M Perry
Aripiprazole (ABILIFY(®)) is an atypical antipsychotic drug that is proposed to act via partial agonism of dopamine D2 receptors. Trials with oral aripiprazole have shown that, compared with some other atypical antipsychotics, aripiprazole is associated with fewer metabolic disturbances and has a favourable cardiovascular tolerability profile. Recently, an intramuscular long-acting injectable (LAI) depot formulation of aripiprazole (ABILIFY MAINTENA(®)) (aripiprazole LAI) has been approved for use as a treatment for schizophrenia in adults...
July 2014: Drugs
https://www.readbyqxmd.com/read/24399490/aripiprazole-a-review-of-its-use-in-the-treatment-of-manic-episodes-in-adolescents-with-bipolar-i-disorder
#16
REVIEW
Kate McKeage
Aripiprazole (Abilify(®)) is an atypical antipsychotic that is widely used in the treatment of psychiatric conditions. Unlike other currently available atypical antipsychotics that primarily have varying degrees of dopamine D2 receptor antagonism, aripiprazole is a partial agonist at D2 and serotonin 5-HT1A receptors, which may explain differences in tolerability profiles. Recently in the EU, oral aripiprazole 10 mg once daily for 12 weeks was approved for the treatment of moderate to severe manic episodes in adolescents (aged ≥13 years) with bipolar I disorder...
February 2014: CNS Drugs
https://www.readbyqxmd.com/read/24358006/a-case-of-teeth-discoloration-upon-transition-from-zyprexa-to-generic-olanzapine
#17
David Galarneau
BACKGROUND: Although crucial to the success of the US healthcare system, generic medication is not without some risks, especially when a transition is made midtreatment from a brand-name formulation to its generic counterpart. Thankfully, such a transition is usually orderly and unnoticed, without disruption to the treatment; however, this is not always the case. CASE REPORT: This case study details an example of 1 such unfortunate disruption to treatment. A stable patient with schizophrenia was switched from brand-name Zyprexa to generic olanzapine...
2013: Ochsner Journal
https://www.readbyqxmd.com/read/23836344/long-acting-injectable-aripiprazole-abilify-maintena-for-schizophrenia
#18
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
April 29, 2013: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/23644169/long-acting-injectable-aripiprazole-how-might-it-fit-in-our-tool-box
#19
REVIEW
Ganesh Gopalakrishna, Arpit Aggarwal, John Lauriello
Schizophrenia is a severe mental illness with a lifetime prevalence of approximately one percent worldwide. Maintenance antipsychotic treatment has been effective in preventing relapses in long-term follow-up studies. Logically it can be proposed that long-acting injectable antipsychotics (LAI) might reduce both unintentional and intentional nonadherence. Long-acting injectable aripiprazole was approved for the treatment of schizophrenia by the U.S. FDA on 28th February 2013 and will be marketed under the name Abilify Maintena...
2013: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/23469485/-is-there-a-place-for-the-physician-s-hopelesness-in-the-treatment-of-depression
#20
W Pitchot
In the treatment of depression, the main objective is to reach complete remission. Unfortunately, this objective remains difficult in clinical practice. In fact, complete remission is frequently considered as an unrealistic objective. It is clear that recovering from major depression is a complicated objective, but it is realistic. In the present paper, we describe the case of a patient suffering from treatment-resistant chronic depression that remitted with a combination of duloxetine (Cymbalta) and aripiprazole (Abilify)...
February 2013: Revue Médicale de Liège
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