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https://www.readbyqxmd.com/read/29208700/hypertension-evoked-rhoa-activity-in-vascular-smooth-muscle-cells-requires-rgs5
#1
Caroline Arnold, Eda Demirel, Anja Feldner, Guillem Genové, Hangjun Zhang, Carsten Sticht, Thomas Wieland, Markus Hecker, Scott Heximer, Thomas Korff
G protein-mediated signaling plays a decisive role in blood pressure regulation and the phenotype of vascular smooth muscle cells (VSMCs); however, the relevance of proteins that restrict G protein activity is not well characterized in this context. Here, we investigated the influence of regulator of G protein signaling 5 (RGS5), an inhibitor of Gαq/11 and Gαi/o activity, on blood pressure and the VSMC phenotype during experimental hypertension. In mice, loss of RGS5 did not affect baseline blood pressure, but prevented hypertension-induced structural remodeling...
December 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29115591/antiangiogenic-effects-of-recombinant-human-endostatin-in-lung-cancers
#2
Lang He, Chaofen Zhao, Yunxiang Li, Guocheng Du, Kang Liu, Dandan Cui, Lina Tang, Xun Wu, Shimin Wen, Hong Chen
Antiangiogenic therapy, as a new anticancer method, can improve the anticancer effect of traditional therapies. Different antiangiogenic drugs may have different vascular normalization time windows. Whether the antiangiogenic treatment is within the vascular normalization time window is very important in the treatment of cancers. Previous studies have indicated that recombinant human endostatin (rh‑ES) can transiently normalize tumor microvessels. Yet the molecular mechanism and the time window of rh‑ES remains unclear...
October 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29061726/angiotensin-ii-type-1-receptor-mechanoactivation-involves-rgs5-regulator-of-g-protein-signaling-5-in-skeletal-muscle-arteries-impaired-trafficking-of-rgs5-in-hypertension
#3
Kwangseok Hong, Min Li, Zahra Nourian, Gerald A Meininger, Michael A Hill
Studies suggest that arteriolar pressure-induced vasoconstriction can be initiated by GPCRs (G protein-coupled receptors), including the AT1R (angiotensin II type 1 receptor). This raises the question, are such mechanisms regulated by negative feedback? The present studies examined whether RGS (regulators of G protein signaling) proteins in vascular smooth muscle cells are colocalized with the AT1R when activated by mechanical stress or angiotensin II and whether this modulates AT1R-mediated vasoconstriction...
December 2017: Hypertension
https://www.readbyqxmd.com/read/28853915/rgs4-overexpression-in-lung-attenuates-airway-hyper-responsiveness-in-mice
#4
Laura A Madigan, Gordon S Wong, Elizabeth M Gordon, Wei-Sheng Chen, Nariman Balenga, Cynthia J Koziol-White, Reynold A Panettieri, Stewart J Levine, Kirk M Druey
A cardinal feature of asthma is airway hyper-responsiveness (AHR) to spasmogens, many of which activate G protein-coupled receptors (GPCRs) on airway smooth muscle (ASM) cells. Asthma subtypes associated with allergy are characterized by eosinophilic inflammation in the lung due to the type 2 immune response to allergens and proinflammatory mediators that promote AHR. The degree to which intrinsic abnormalities of ASM contribute to this phenotype remains unknown. The Regulators of G protein signaling (RGS proteins) are a large group of intracellular proteins that inhibit GPCR signaling pathways...
August 30, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28736108/chronic-intermittent-ethanol-exposure-selectively-alters-the-expression-of-g%C3%AE-subunit-isoforms-and-rgs-subtypes-in-rat-prefrontal-cortex
#5
D J Luessen, H Sun, M M McGinnis, B A McCool, R Chen
Chronic alcohol exposure induces pronounced changes in GPCR-mediated G-protein signaling. Recent microarray and RNA-seq analyses suggest associations between alcohol abuse and the expression of genes involved in G-protein signaling. The activity of G-proteins (e.g. Gαi/o and Gαq) is negatively modulated by regulator of G-protein signaling (RGS) proteins which are implicated in drugs of abuse including alcohol. The present study used 7days of chronic intermittent ethanol exposure followed by 24h withdrawal (CIE) to investigate changes in mRNA and protein levels of G-protein subunit isoforms and RGS protein subtypes in rat prefrontal cortex, a region associated with cognitive deficit attributed to excessive alcohol drinking...
October 1, 2017: Brain Research
https://www.readbyqxmd.com/read/28684360/regulator-of-g-protein-signaling-5-rgs5-inhibits-sonic-hedgehog-function-in-mouse-cortical-neurons
#6
Chuanliang Liu, Qiongqiong Hu, Jia Jing, Yun Zhang, Jing Jin, Liulei Zhang, Lili Mu, Yumei Liu, Bo Sun, Tongshuai Zhang, Qingfei Kong, Guangyou Wang, Dandan Wang, Yao Zhang, Xijun Liu, Wei Zhao, Jinghua Wang, Tao Feng, Hulun Li
Regulator of G protein signaling 5 (RGS5) acts as a GTPase-activating protein (GAP) for the Gαi subunit and negatively regulates G protein-coupled receptor signaling. However, its presence and function in postmitotic differentiated primary neurons remains largely uncharacterized. During neural development, sonic hedgehog (Shh) signaling is involved in cell signaling pathways via Gαi activity. In particular, Shh signaling is essential for embryonic neural tube patterning, which has been implicated in neuronal polarization involving neurite outgrowth...
July 3, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28345526/aspects-of-pericytes-and-their-potential-therapeutic-use
#7
REVIEW
Justyna Różycka, Edyta Brzóska, Tomasz Skirecki
Pericytes, which are multi-potential stem cells, co-create the walls of the microvessels: capillaries, terminal arterioles and postcapillary venules. These cells are localized under the basement membrane, tightly encircling the endothelium. The most frequently mentioned molecular markers of pericytes include NG2 (neural-glial antigen 2), β-type platelet-derived growth factor receptor (PDGFRβ), smooth muscle α-actin (α-SMA), regulator of G protein signalling 5 (RGS5), the adhesion protein CD146 and nestin...
March 13, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28330473/dynamic-and-specific-immune-responses-against-multiple-tumor-antigens-were-elicited-in-patients-with-hepatocellular-carcinoma-after-cell-based-immunotherapy
#8
Yanyan Han, Yeting Wu, Chou Yang, Jing Huang, Yabing Guo, Li Liu, Ping Chen, Dongyun Wu, Junyun Liu, Jin Li, Xiangjun Zhou, Jinlin Hou
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common cancers in China and frequently occurs with chronic hepatitis B virus infection. To investigate whether cell-based cancer immunotherapy induces tumor specific immune responses in patients with HCC and provides clinical benefits, as well as to elucidate the most immunogenic tumor associated antigens (TAAs), multiple antigen stimulating cellular therapy (MASCT) was applied in addition to standard of care. METHODS: Mature dendritic cells (DCs) and activated T cells prepared for MASCT were generated from autologous peripheral blood mononuclear cells (PBMCs)...
March 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27611366/ruminal-expression-of-the-nqo1-rgs5-and-acat1-genes-may-be-indicators-of-feed-efficiency-in-beef-steers
#9
R J Kern, C M Zarek, A K Lindholm-Perry, L A Kuehn, W M Snelling, H C Freetly, H C Cunningham, A M Meyer
Ruminal genes differentially expressed in crossbred beef steers from USMARC with variation in gain and feed intake were identified in a previous study. Several of the genes identified with expression patterns differing between animals with high gain-low feed intake and low gain-high feed intake were evaluated in a separate, unrelated population of Angus × Hereford beef steers from the University of Wyoming that was classified to differ in residual feed intake (RFI). Of the 17 genes tested, two were differentially expressed by RFI class in the Angus × Hereford animals...
February 2017: Animal Genetics
https://www.readbyqxmd.com/read/27510330/pericytes-for-the-treatment-of-orthopedic-conditions
#10
REVIEW
Aaron W James, Paul Hindle, Iain R Murray, Christopher C West, Tulyapruek Tawonsawatruk, Jia Shen, Greg Asatrian, Xinli Zhang, Vi Nguyen, A Hamish Simpson, Kang Ting, Bruno Péault, Chia Soo
Pericytes and other perivascular stem cells are of growing interest in orthopedics and tissue engineering. Long regarded as simple regulators of angiogenesis and blood pressure, pericytes are now recognized to have MSC (mesenchymal stem cell) characteristics, including multipotentiality, self-renewal, immunoregulatory functions, and diverse roles in tissue repair. Pericytes are typified by characteristic cell surface marker expression (including αSMA, CD146, PDGFRβ, NG2, RGS5, among others). Although alone no marker is absolutely specific for pericytes, collectively these markers appear to selectively identify an MSC-like pericyte...
March 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27376129/independent-replication-of-published-germline-polymorphisms-associated-with-urinary-bladder-cancer-prognosis-and-treatment-response
#11
Anne J Grotenhuis, Aleksandra M Dudek, Gerald W Verhaegh, Katja K Aben, J Alfred Witjes, Lambertus A Kiemeney, Sita H Vermeulen
BACKGROUND: Many studies investigated the prognostic or predictive relevance of single nucleotide polymorphisms (SNPs) in biologically plausible genes in urinary bladder cancer (UBC) patients. Most published SNP associations have never been replicated in independent patient series. OBJECTIVE: To independently replicate all previously reported associations between germline SNPs and disease prognosis or treatment response in UBC. METHODS: A Pubmed search was performed to identify studies published by July 1, 2014 reporting on germline SNP associations with UBC prognosis or treatment response...
2016: Bladder Cancer
https://www.readbyqxmd.com/read/27355827/a-conserved-microrna-regulatory-circuit-is-differentially-controlled-during-limb-appendage-regeneration
#12
Benjamin L King, Viravuth P Yin
BACKGROUND: Although regenerative capacity is evident throughout the animal kingdom, it is not equally distributed throughout evolution. For instance, complex limb/appendage regeneration is muted in mammals but enhanced in amphibians and teleosts. The defining characteristic of limb/appendage regenerative systems is the formation of a dedifferentiated tissue, termed blastema, which serves as the progenitor reservoir for regenerating tissues. In order to identify a genetic signature that accompanies blastema formation, we employ next-generation sequencing to identify shared, differentially regulated mRNAs and noncoding RNAs in three different, highly regenerative animal systems: zebrafish caudal fins, bichir pectoral fins and axolotl forelimbs...
2016: PloS One
https://www.readbyqxmd.com/read/27189971/vascular-and-central-activation-of-peroxisome-proliferator-activated-receptor-%C3%AE-attenuates-angiotensin-ii-induced-hypertension-role-of-rgs-5
#13
Miguel Romero, Rosario Jiménez, Marta Toral, Elvira León-Gómez, Manuel Gómez-Gúzman, Manuel Sánchez, María José Zarzuelo, Isabel Rodríguez-Gómez, Geraldine Rath, Juan Tamargo, Francisco Pérez-Vizcaíno, Chantal Dessy, Juan Duarte
Activation of peroxisome proliferator-activated receptor-β/δ (PPARβ) lowers blood pressure in genetic and mineralocorticoid-induced hypertension. Regulator of G-protein-coupled receptor signaling 5 (RGS5) protein, which interferes in angiotensin II (AngII) signaling, is a target gene to PPARβ The aim of the present study was to examine whether PPARβ activation in resistance arteries and brain tissues prevents the elevated blood pressure in AngII-induced hypertension and evaluate the role of RGS5 in this effect...
July 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27146030/endometrial-mesenchymal-stem-stromal-cells-their-fibroblast-progeny-in-endometriosis-and-more
#14
Caroline E Gargett, Shanti Gurung
No abstract text is available yet for this article.
June 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27063472/pericytic-mimicry-in-well-differentiated-liposarcoma-atypical-lipomatous-tumor
#15
Jia Shen, Swati Shrestha, P Nagesh Rao, Greg Asatrian, Michelle A Scott, Vi Nguyen, Paulina Giacomelli, Chia Soo, Kang Ting, Fritz C Eilber, Bruno Peault, Sarah M Dry, Aaron W James
Pericytes are modified smooth muscle cells that closely enwrap small blood vessels, regulating and supporting the microvasculature through direct endothelial contact. Pericytes demonstrate a distinct immunohistochemical profile, including expression of smooth muscle actin, CD146, platelet-derived growth factor receptor β, and regulator of G-protein signaling 5. Previously, pericyte-related antigens have been observed to be present among a group of soft tissue tumors with a perivascular growth pattern, including glomus tumor, myopericytoma, and angioleiomyoma...
August 2016: Human Pathology
https://www.readbyqxmd.com/read/27021681/regulator-of-g-protein-signaling-5-protects-cardiomyocytes-against-apoptosis-during-in%C3%A2-vitro-cardiac-ischemia-reperfusion-in-mice-by-inhibiting-both-jnk1-2-and-p38-signaling-pathways
#16
Zhiqiang Wang, He Huang, Wangwei He, Bin Kong, He Hu, Yang Fan, Jiafen Liao, Lei Wang, Yang Mei, Wanli Liu, Xiaoju Xiong, Jianye Peng, Yali Xiao, Dan Huang, Dajun Quan, Qi Li, Liang Xiong, Peng Zhong, Guangji Wang
Ischemic heart disease is one of the most common diseases in modern society. Ischemic myocardium can be salvaged by vascular recanalization therapy, but its benefit is attenuated by injury that can occur during reperfusion. And apoptotic cell death plays an important part in myocardial ischemia-reperfusion (IR) injury. Regulator of G-protein signaling 5 (RGS5), highly expressed in different cell types of the human adult heart, is a guanosine triphosphatase-activating protein to inhibit many signaling pathways such as c-Jun NH2-terminal kinase 1/2 (JNK1/2) and p38 which promote cardiac IR-induced apoptosis...
April 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26974145/predictive-biomarkers-candidates-for-patients-with-metastatic-colorectal-cancer-treated-with-bevacizumab-containing-regimen
#17
REVIEW
Nicolás González-Vacarezza, Isabel Alonso, Gustavo Arroyo, Jorge Martínez, Fernando De Andrés, Adrián LLerena, Francisco Estévez-Carrizo
Bevacizumab was the first molecular-targeted antiangiogenic therapy approved for the treatment of metastatic colorectal cancer. Until now, there are no predictive biomarkers available to decide the prescription of bevacizumab in patients with colorectal cancer. The purposes of this review were to provide a critical appraisal of the evidence and to identify possible predictive genetic biomarkers. A literature search was performed to identify studies that determine different levels of treatment response between patients stratified according to defined biomarkers...
June 1, 2016: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/26961238/potential-role-of-regulator-of-g-protein-signaling-5-in-the-protection-of-vagal-related-bradycardia-and-atrial-tachyarrhythmia
#18
Mu Qin, Xu Liu, Tao Liu, Teng Wang, Congxin Huang
BACKGROUND: The regulator of G-protein signaling 5 (Rgs5), which functions as the regulator of G-protein-coupled receptor (GPCR) including muscarinic receptors, has a potential effect on atrial muscarinic receptor-activated IKA ch current. METHODS AND RESULTS: In the present study, hearts of Rgs5 knockout (KO) mice had decreased low-frequency/high-frequency ratio in spectral measures of heart rate variability. Loss of Rgs5 provoked dramatically exaggerated bradycardia and significantly (P<0...
March 9, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26936785/relaxin-deficiency-attenuates-pregnancy-induced-adaptation-of-the-mesenteric-artery-to-angiotensin-ii-in-mice
#19
Sarah A Marshall, Chen Huei Leo, Sevvandi N Senadheera, Jane E Girling, Marianne Tare, Laura J Parry
Pregnancy is associated with reduced peripheral vascular resistance, underpinned by changes in endothelial and smooth muscle function. Failure of the maternal vasculature to adapt correctly leads to serious pregnancy complications, such as preeclampsia. The peptide hormone relaxin regulates the maternal renal vasculature during pregnancy; however, little is known about its effects in other vascular beds. This study tested the hypothesis that functional adaptation of the mesenteric and uterine arteries during pregnancy will be compromised in relaxin-deficient (Rln(-/-)) mice...
May 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/26663397/regulator-of-g-protein-signaling-5-prevents-smooth-muscle-cell-proliferation-and-attenuates-neointima-formation
#20
Jan-Marcus Daniel, André Prock, Jochen Dutzmann, Kristina Sonnenschein, Thomas Thum, Johann Bauersachs, Daniel G Sedding
OBJECTIVE: Regulator of G-protein signaling 5 (RGS5) is abundantly expressed in vascular smooth muscle cells (SMCs) and inhibits G-protein signaling by enhancing the guanosine triphosphate-hydrolyzing activity of Gα-subunits. In the present study, we investigated the effects of RGS5 on vascular SMC function in vitro and neointima formation after wire-induced injury in mice and determined the underlying mechanisms. APPROACH AND RESULTS: We found a robust expression of RGS5 in native arteries of C57BL/6 mice and a highly significant downregulation within neointimal lesions 10 and 21 days after vascular injury as assessed by quantitative polymerase chain reaction, immunoblotting, and immunohistochemistry...
February 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
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