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Alyaa Amal Kotby, Omneya Ibrahim Youssef, Mohamed Omar Elmaraghy, Osama Salah El Sharkawy
Heart failure (HF) progression has not been studied in pediatric patients as well as HF in patients with a normal ejection fraction (HFNEF). We aimed to evaluate galactin-3 in children with HFNEF and reduced ejection fraction (HFREF) and its correlation to disease severity and progression. This cross-sectional study involved 45 chronic HF patients taking G1a (23 HFNEF children) and G1b (22 HFREF children) compared to 45 age- and sex-matched controls (G2) subjected to history taking, Ross functional HF classification, conventional and tissue Doppler echocardiographic systolic and diastolic function assessment (FS%, E/A, S m, E m/A m, E/E m) and laboratory investigations [glomerular filtration rate, serum galactin-3 level (ELISA)]...
January 2017: Pediatric Cardiology
Leandro Rocha Messias, Aryanne Guimarães Ferreira, Sandra Marina Ribeiro de Miranda, José Antônio Caldas Teixeira, Jader Cunha de Azevedo, Ana Carolina Nader Vasconcelos Messias, Elisabeth Maróstica, Claudio Tinoco Mesquita
BACKGROUND: More than 50% of the patients with heart failure have normal ejection fraction (HFNEF). Iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy and cardiopulmonary exercise test (CPET) are prognostic markers in HFNEF. Nebivolol is a beta-blocker with vasodilating properties. OBJECTIVES: To evaluate the impact of nebivolol therapy on CPET and123I-MIBG scintigraphic parameters in patients with HFNEF. METHODS: Twenty-five patients underwent 123I-MIBG scintigraphy to determine the washout rate and early and late heart-to-mediastinum ratios...
May 2016: Arquivos Brasileiros de Cardiologia
Mehrnoush Toufan, Saeed Mohammadzadeh Gharebaghi, Leili Pourafkari, Elham Delir Abdolahinia
BACKGROUND: Echocardiographic evaluations of the longitudinal axis of the left ventricular (LV) function have been used in the diagnosis and assessment of heart failure with normal ejection fraction (HFNEF). The evaluation of the global and segmental peak systolic longitudinal strains (PSLSs) by two-dimensional speckle tracking echocardiography (STE) may correlate with conventional echocardiography findings. We aimed to use STE to evaluate the longitudinal function of the LV in patients with HFNEF...
October 27, 2015: Journal of Tehran Heart Center
Liyew Desta, Tomas Jernberg, Jonas Spaak, Claes Hofman-Bang, Hans Persson
AIM: Data are scant on the incidence and prognosis of heart failure (HF) with normal ejection fraction (HFNEF, EF >49%) in an acute myocardial infarction (AMI) setting. The aim of this study was to examine incidence and predictors of HFNEF during an index acute myocardial infarction (AMI) and its subsequent associations with patient outcomes. METHODS AND RESULTS: This study analysed 91 360 patients with LVEF data from the SWEDEHEART registry on consecutive AMI patients between 1998 and 2010...
January 2016: European Journal of Heart Failure
Jufen Zhang, James Hobkirk, Sean Carroll, Pierpaolo Pellicori, Andrew L Clark, John G F Cleland
AIMS: The EuroHeart Failure Survey Questionnaire (EHFSQ-1) has 39 questions on symptoms and quality of life (QoL); many items are related. We sought to identify underlying clusters amongst EHFSQ-1 questions, construct an overall "QoL score" and investigate its relationship to a single question asking patients to self-rate QoL. METHODS AND RESULTS: Factor analysis based on the principal component technique was used to identify patterns amongst responses to QoL questions from patients referred with symptoms suggesting heart failure (HF)...
January 1, 2016: International Journal of Cardiology
Shane Nanayakkara, David M Kaye
PURPOSE: The purpose of this article was to review the clinical management of patients with heart failure with preserved ejection fraction (HFPEF). METHODS: For this critical review, electronic databases (MEDLINE, EMBASE, PubMed) were searched for relevant basic research studies and randomized clinical trials recently published or presented at major meetings. Details of in-progress or planned studies were obtained from the website. The range of publication dates was the year 2000 to 2015...
October 1, 2015: Clinical Therapeutics
Andreas Ritzel, Florian Otto, Michael Bell, Georg Sabin, Heinrich Wieneke
BACKGROUND: Heart failure with normal left ventricular ejection fraction (HFNEF) accounts for about one third of all heart failure patients with considerable mortality. The metabolic syndrome (MS) is a risk factor for diastolic dysfunction and HFNEF. We hypothesized that modifying metabolic burden by exercise training and weight loss might improve left ventricular diastolic function, heart failure symptoms and rehospitalization rate. METHODS AND RESULTS: Forty patients with HFNEF, MS and prediabetes were enrolled in this prospective study...
February 2015: Acta Cardiologica
Jaroslav Meluzin, Zdenka Gregorova, Monika Spinarova, Roman Panovsky
BACKGROUND: A significant proportion of patients with exertional dyspnea require exercise to diagnose heart failure with normal ejection fraction (HFNEF). METHODS AND RESULTS: In this review article, we evaluate current data on the prevalence, clinical significance and specifically the establishment of a diagnosis of isolated, exercise-induced HFNEF. Despite the unquestioned clinical importance and high prevalence of exercise-induced HFNEF, there are limited and conflicting data on making a diagnosis of exercise-induced HFNEF...
December 2015: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Yi-Chih Wang, Chih-Chieh Yu, Fu-Chun Chiu, Vincent Splett, Ruth Klepfer, Kathryn Hilpisch, Chia-Ti Tsai, Ling-Ping Lai, Juey-Jen Hwang, Jiunn-Lee Lin
OBJECTIVES: We tested the acute effects of resynchronization in heart failure patients with a normal (>50%) left ventricular (LV) ejection fraction (HFNEF) and mechanical dyssynchrony. METHODS: Twenty-four HFNEF patients (72 ± 6 years, 5 male) with mechanical dyssynchrony (standard deviation of electromechanical time delay among 12 LV segments >35 ms) were studied with temporary pacing catheters in the right atrium, LV, and right ventricle (RV), and high-fidelity catheters for pressure recording...
2015: Cardiology
Victor Dayan, Veronica Sotelo, Valentina Delfina, Natalia Delgado, Carlos Rodriguez, Carol Suanes, María Langhain, Rodolfo Ferrando, Cristina Touriño, Alejandro Benech
BACKGROUND: Ischemic heart failure with normal ejection fraction (HFNEF) is an increasingly recognized entity that carries similar morbidity and mortality than low ejection fraction heart failure. Animal models of diastolic dysfunction mimicking this condition are lacking and are essential for the development of therapeutic strategies. METHODS AND RESULTS: Eight Corriedale sheep, 18 ± 5 months old, were included in the study. Basal echocardiography and myocardial perfusion evaluation (SPECT) was performed...
April 2015: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Guodong Ma, Ming Xu, Wei Gao, Zhaoping Li, Weihong Li, Baoxia Chen, Jieli Feng, Hongyan Wang, Wenying Ma, Hui Chen, Aidong Shen, Xinheng Feng, Yongzhen Zhang
BACKGROUND: Hypertrophic cardiomyopathy (HCM) patients are more susceptible to suffer from heart failure with normal ejection fraction (HFNEF). Therefore, it is critical to evaluate the relationship between left ventricular filling pressure (LVFP) and HFNEF, even if a large proportion of HCM patients have normal LVFP at rest. The objective was to assess the correlation between exercise tissue Doppler imaging (TDI) and early HFNEF in HCM patients by treadmill exercise echocardiography combined with cardiopulmonary exercise test (CPET)...
December 18, 2014: BMC Cardiovascular Disorders
Zdeňka Gregorová, Jaroslav Meluzín, Lenka Spinarová
Heart failure with preserved ejection fraction of left ventricle (heart failure with normal ejection fraction, HFPEF, HFNEF) is frequent disease with serious consequences. Incidence of HFPEF in population is still growing. The exact pathophysiological mechanism of HFPEF remain unclear .Recent evidence suggests a relationship between inflammation associated with obesity or Diabetes mellitus and progression of HFPEF. Consistently, it has been reported that serum concentration of some pro-inflammatory markers such as adiponectin is positively related to HFPEF...
July 2014: Vnitr̆ní Lékar̆ství
Jing Wang, Fang Fang, Gabriel Wai-Kwok Yip, John E Sanderson, Pui-Wai Lee, Wei Feng, Jun-Min Xie, Xiu-Xia Luo, Yat-Yin Lam
AIMS: We assessed the left ventricular (LV) and peripheral performance at rest and during exercise in healthy and heart failure subjects with normal ejection fraction (HFNEF) or with reduced ejection fraction (HFREF). METHODS: All subjects received echocardiography at rest and with bicycle Ergometer exercise. The exercise images for two-dimensional speckle tracking were acquired with submaximal heart rate of 90-100 beats/min, while images for M-mode and tissue Doppler imaging were stored with attainment of >85% of predicted heart rate...
August 2014: European Journal of Heart Failure
Junichi Matsubara, Seigo Sugiyama, Toshimitsu Nozaki, Eiichi Akiyama, Yasushi Matsuzawa, Hirofumi Kurokawa, Hirofumi Maeda, Koichiro Fujisue, Koichi Sugamura, Eiichiro Yamamoto, Kunihiko Matsui, Hideaki Jinnouchi, Hisao Ogawa
BACKGROUND: Pentraxin 3 (PTX3) is a novel inflammatory marker produced by various cell types including those of the vasculature and the heart. The relationship between inflammatory markers and prognosis of patients with heart failure with normal ejection fraction (HFNEF) remains unknown. We investigated whether plasma PTX3 levels can predict future cardiovascular events in patients with HFNEF. METHODS AND RESULTS: Plasma PTX3, high-sensitivity C-reactive protein, and B-type natriuretic peptide levels were measured prospectively in 360 stable patients with HFNEF...
July 10, 2014: Journal of the American Heart Association
Evandro Tinoco Mesquita, Antonio Jose Lagoeiro Jorge, Celso Vale de Souza Junior, João Paulo Pedroza Cassino
Heart failure with normal ejection fraction (HFNEF) is currently the most prevalent clinical phenotype of heart failure. However, the treatments available have shown no reduction in mortality so far. Advances in the omics sciences and techniques of high data processing used in molecular biology have enabled the development of an integrating approach to HFNEF based on systems biology. This study aimed at presenting a systems-biology-based HFNEF model using the bottom-up and top-down approaches. A literature search was conducted for studies published between 1991 and 2013 regarding HFNEF pathophysiology, its biomarkers and systems biology...
May 2014: Arquivos Brasileiros de Cardiologia
Guanhua Su, Heng Cao, Sudan Xu, Yongxin Lu, Xinxin Shuai, Yufei Sun, Yuhua Liao, Jingdong Li
How to identify the early signs of hypertensive heart disease is the key to block or reverse the process of heart failure. The aim of this study was to evaluate the predictive value of left atrial (LA) enlargement in the early stage of hypertensive heart disease and to explore the correlations between LA enlargement and heart failure with normal ejection fraction (HFnEF), as well as the metabolic syndrome (MetS). Baseline clinical characteristics, biochemical indices, electrocardiographic and echocardiographic data were collected from 341 consecutive patients with essential hypertension...
March 2014: Journal of Clinical Hypertension
Guo-Liang Zou, Wei-Li Zhong, Yan-Bo Sui, Juan Jin, Li Liu
OBJECTIVE: To study the effect of blood activating water relieving method (BAWRM) on heart functions and serum levels of NT-proBNP in patients with heart failure with normal ejection fraction (HFNEF). METHODS: Sixty-four HFNEF patients were admitted to our hospital during January 2011 to June 2012. They were randomly assigned to the treatment group (32 cases) and the control group (32 cases). Patients in the control group received routine Western medical treatment, while those in the treatment group additionally took Chinese medical recipes for activating blood circulation and relieving water retention...
February 2014: Chinese Journal of Integrated Traditional and Western Medicine
John E Sanderson
It is well recognized that many patients presenting with heart failure have a normal left ventricular ejection fraction. There has been debate about the correct name for this condition including originally Diastolic Heart Failure (DHF), Heart Failure with a Normal Ejection Fraction (HFNEF), and more recently Heart Failure with a Preserved Ejection Fraction, usually abbreviated to HFpEF. In this viewpoint is it argued that 'Preserved' is the least appropriate word to use, as ejection fraction declines over time and furthermore it is never explained why the 'p' is small...
February 2014: JACC. Heart Failure
Jaroslav Meluzin, Petr Hude, Pavel Leinveber, Jan Krejci, Lenka Spinarova, Helena Bedanova, Helena Podrouzkova, Radka Stepanova, Petr Nemec
AIM: Post-heart transplant patients are at increased risk of diastolic dysfunction. The aim of this study was to assess the prevalence of isolated only exercise-induced heart failure with normal ejection fraction (HFNEF) in heart transplant recipients. METHODS AND RESULTS: To determine pulmonary capillary wedge pressure (PCWP) at rest and during exercise, 81 patients after orthotopic heart transplantation with normal left ventricular ejection fraction (LVEF) underwent exercise right heart catheterization with simultaneous exercise echocardiography...
June 2014: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Mark E Dunlap, W H Wilson Tang
No abstract text is available yet for this article.
January 2014: Journal of Cardiac Failure
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