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Mycosis fungoide

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https://www.readbyqxmd.com/read/29470304/index-case-of-cutaneous-follicular-mycosis-fungoides-with-central-nervous-system-involvement-and-review-of-literature
#1
Giang Huong Nguyen, Alexander Mohler, Michelle Leppert, Cindy Parra, Yue-Ping Zeng, Lori Prok, Jeffrey Schowinsky, Cynthia M Magro, Theresa Pacheco, Douglas Ney
Central nervous system involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages of the disease. We describe a patient with early-stage follicular MF who presented with changes in mental status. Despite an initial diagnosis of vasculitis based on clinical and brain biopsy results, the postmortem examination revealed extensive infiltration of MF cells throughout the brain with leptomeningeal involvement. This case in addition to the accompanied review of literature illustrates the importance of the awareness of central nervous system involvement by MF and highlights the need for an urgent neurologic evaluation in patients with a history of MF now presenting with neurologic signs or symptoms...
March 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29469767/eosinophilic-infiltrate-resembling-eosinophilic-cellulitis-wells-syndrome-in-a-patient-with-mycosis-fungoides
#2
Drew A Emge, Daniel J Lewis, Phyu P Aung
Mycosis fungoides (MF) is a T-cell, non-Hodgkin lymphoma that primarily involves the skin. Extracutaneous involvement, such as in the parotidgland, is characteristic of end-stage disease. Eosinophilic cellulitis, or Wells syndrome, is a rare inflammatory dermatitis that involves a dermal infiltrate of eosinophils. We report a case of an 80-year-old man with a long-standing diagnosis of stage IIB MF who acutely developed parotid gland involvement and marked hypereosinophilia that most likely represented eosinophilic cellulitis...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469744/folliculin-mutation-negative-trichodiscomas-in-a-patient-with-multiple-endocine-neoplasia-type-i-syndrome
#3
Jennifer E Yeh, Steven R Tahan, Susan Burgin
Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma that involves the oral mucosal. The manifestation of lesions within the oral cavity generally correlates with a poor prognosis. Management of MF includes skin directed therapies and localized radiation treatment, with systemic biologic therapies and chemotherapy used for more advanced stages. The clinical and histologic features of MF in a patient with oral disease are reviewed.
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469726/psoriasiform-mycosis-fungoides-a-rare-form-of-the-disease-with-review-of-the-literature
#4
Arghavan Azizpour, Alireza Ghanadan, Maryam Nasimi, Ifa Etesami
BACKGROUND: Mycosis fungoides (MF) typically presents as erythematous scaly patches or plaques that may progress to cutaneous tumors. Although MF may be presented like other dermatoses, initial presentation as psoriasiform plaques simulating psoriasis is rare. Differentiating MF from psoriasis is important because systemic therapies used for psoriasis can worsen MF. We describe a case of psoriasiform MF and we also review the clinicopathological features of similar cases in the literature...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29457018/nail-changes-in-early-mycosis-fungoides
#5
Amir Hooshang Ehsani, Maryam Nasimi, Arghavan Azizpour, Pedram Noormohammadpoor, Kambiz Kamyab, Hasan Seirafi, Mojghan Noori
Background: Mycosis fungoides (MF) has a wide range of clinical presentations and it has been reported rarely to involve the nail apparatus. Objective: We intended to evaluate the frequency and characteristics of nail changes in patients with biopsy-proven MF. Methods: A retrospective analysis of 60 patients with MF who were evaluated at our cancer center from 2013 to 2014 was performed to identify patients with nail changes. Histological examinations of the skin around the nail apparatus were obtained from 10 patients with periungual skin erythema and scaling...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29449683/adult-t-cell-leukemia-lymphoma-can-be-indistinguishable-from-other-more-common-t-cell-lymphomas-the-university-of-miami-experience-with-a-large-cohort-of-cases
#6
Mahsa Khanlari, Juan Carlos Ramos, Sandra Patricia Sanchez, Jeong Hee Cho-Vega, Alexandra Amador, German Campuzano-Zuluaga, Francisco Vega, Jennifer R Chapman
Adult T-cell leukemia/lymphoma, an aggressive T-cell neoplasm, is causally linked to human T-cell lymphotropic virus type 1 and based on this association has a distinct geographic distribution. In our United States-based practice, whose population is enriched for immigrants from human T-cell lymphotropic virus type 1 endemic areas, we have identified that a subset of adult T-cell leukemia/lymphoma, in the absence of human T-cell lymphotropic virus type 1 identification, are indistinguishable from other more common T-cell neoplasms...
February 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29445460/case-report-photo-onycholysis-after-puva-treatment-for-hypopigmented-mycosis-fungoides-with-response-to-topical-steroid
#7
Paul Jie Wen Tern, Julia Gass
Melanin in the nail bed in patients with skin type VI has been suggested to afford some protection against photo-onycholysis. We report a case of a 16-year-old male patient with skin type VI with onycholysis following PUVA treatment for hypopigmented mycosis fungoides. Symptoms resolved with the application of topical steroid.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29440874/clinical-potential-of-mechlorethamine-gel-for-the-topical-treatment-of-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-a-review-on-current-efficacy-and-safety-data
#8
REVIEW
Kendall Liner, Celeste Brown, Laura Y McGirt
Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. The authors in this review found that while the gel formulation may result in a decrease of allergic contact dermatitis, this advantage has been replaced by a higher number of irritant contact reactions and a decrease in complete response rate...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29437735/successful-treatment-of-extensive-splanchnic-vein-thrombosis-in-a-patient-with-mycosis-fungoides
#9
Nishtha Sanjay Nagral, Vijay Waman Dhakre, Nirzar Parikh, Shaji Marar
A 33-year-old man of a Middle Eastern origin presented to us with abdominal pain and distension secondary to refractory ascites of 1-month duration. The patient had a history of taking oral retinoic acid 25 mg for 4 months for mycosis fungoides. Investigations revealed thrombosis of hepatic veins with extensive thrombosis of the porto-mesenteric axis. A combination of transjugular intrahepatic portosystemic shunt, balloon angioplasty and thrombolysis with recombinant tissue plasminogen activator was successfully used to treat his condition...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29417797/verrucous-mycosis-fungoides
#10
Michelangelo LA Placa, Aurora Alessandrini, Claudio Agostinelli, Alessandro Pileri
No abstract text is available yet for this article.
February 7, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29405482/molecular-genetic-analyses-of-human-endogenous-retroviral-elements-belonging-to-the-herv-p-and-r-family-in-primary-cutaneous-t-cell-lymphomas
#11
Massimiliano Bergallo, Paolo Fava, Ilaria Galliano, Mauro Novelli, Paola Montanari, Valentina Daprà, Marco Rassu, Pietro Quaglino, Maria Teresa Fierro
Mycosis fungoides (MF) is characterized by longstanding, scaly patch lesions preferentially involving the buttocks and body areas infrequently exposed to sunlight and by a slow evolution over years from patches to plaques and eventually tumors or erythroderma. Lymph node and visceral involvement, as well as large cell transformation, frequently occur in the late stages of the disease [1]. Sézary syndrome (SS) is an erythrodermic cutaneous T-cell lymphoma (CTCL) with leukemic involvement, an aggressive clinical behavior and poor prognosis [2]...
February 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29386841/hypopigmented-mycosis-fungoides-treated-with-308-nm-excimer-laser
#12
Min-Young Yang, Hyunju Jin, Hyang-Suk You, Woo-Haing Shim, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
No abstract text is available yet for this article.
February 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29381224/the-pathological-spectrum-and-clinical-correlation-of-pigmented-purpuric-dermatosis-a-retrospective-review-of-107-cases
#13
Yen-Kai Huang, Cheng-Kuan Lin, Yu-Hung Wu
BACKGROUND: Various pathological findings have been reported in pigmented purpuric dermatosis, but their clinical significance remains unclear. METHODS: We retrospectively reviewed demographics, clinical presentations, pathological patterns, and concurrent systemic diseases among biopsy-confirmed cases of pigmented purpuric dermatosis. RESULTS: A total of 107 cases were ascertained. Five major pathological patterns were identified: lichenoid (45/107, 42...
January 30, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29378678/type-d-cd8-lymphomatoid-papulosis-in-a-patient-with-classic-cd4-mycosis-fungoides
#14
Junko Hori-Kosogabe, Toshihisa Hamada, Shin Morizane, Yoji Hirai, Tomoko Miyake, Tadashi Yoshino, Keiji Iwatsuki
No abstract text is available yet for this article.
January 29, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29368862/clinical-and-histological-evaluation-in-patients-with-mycosis-fungoides-treated-with-uva1
#15
Emanuele Trovato, Michele Pellegrino, Federica Filippi, Virginia Mancini, Nicola Pimpinelli, Michele Fimiani
BACKGROUND: UVA1 phototherapy is a valid therapeutic alternative for skin lymphoproliferative disorders, although there are few studies concerning its role in mycosis fungoides (MF). Our aim was to evaluate and confirm the effectiveness of UVA1 phototherapy in patients in early stage Mycosis Fungoides (MF). METHODS: We enrolled 12 patients, 9 males and 3 females (mean age 54.83 ± 9.99, range 36-74) with a histological diagnosis of mycosis fungoides at early stage...
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29361381/drug-induced-pseudolymphoma
#16
REVIEW
Cynthia M Magro, Brianne H Daniels, A Neil Crowson
Atypical lymphocytic infiltrates of the skin comprise a broad spectrum of entities ranging from benign infiltrates to those that are malignant. Many of these infiltrates are in fact reactive lymphomatoid ones related to drug therapy falling under the general category of drug associated pseudolymphoma. Within this nosologic umbrella are nodular and diffuse infiltrates resembling low grade T and B cell lymphoma consistent with lymphocytoma cutis, drug associated reversible T cell dyscrasias which draw a strong morphologic and phenotypic parallel with mycosis fungoides and the various pre-lymphomatous T cell dyscrasias, and angiocentric CD30 positive infiltrates mirroring lymphomatoid papulosis...
January 17, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29356170/t-cell-papulosis-associated-with-b-cell-malignancy-a-distinctive-clinicopathologic-entity
#17
L V Visseaux, A D Durlach, S B Barete, M B B Beylot-Barry, N B Bonnet, A F C Chassine, N F Franck, G H Herve, C L Leclec'h, L M Machet, S I O Ingen-Housz-Oro, T P Petrella, B V Vergier, N O Ortonne, F G Grange
BACKGROUND: A distinctive eruption referred to as "insect bite-like reaction", or "eosinophilic dermatosis of hematologic malignancy" has been described during the course of hematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear. OBJECTIVES: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM. METHODS: In this multicenter retrospective study of the French Study Group on Cutaneous Lymphomas, 37 patients with a BCM and a cutaneous eruption consisting in chronic and/or recurrent papules, papulo-vesicles and/or nodules were included...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29341283/mogamulizumab-induced-photosensitivity-in-patients-with-mycosis-fungoides-and-other-t-cell-neoplasms
#18
Y Masuda, K Tatsuno, S Kitano, H Miyazawa, J Ishibe, M Aoshima, T Shimauchi, T Fujiyama, T Ito, Y Tokura
BACKGROUND: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma. OBJECTIVE: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T-cell neoplasms after treatment with Mog. METHODS: We treated seven cutaneous lymphoma patients with Mog...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29336316/mycosis-fungoides-in-patients-with-psoriasis-an-ongoing-issue
#19
Despoina Papathemeli, Elisavet Georgiou, Triantafyllia Koletsa, Dimitrios Sotiriadis, Aikaterini Patsatsi
No abstract text is available yet for this article.
January 16, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29327377/s%C3%A3-zary-syndrome-managed-with-histone-deacetylase-inhibitor-followed-by-anti-ccr4-monoclonal-antibody
#20
T Numata, T Nagatani, K Shirai, T Maeda, K Mae, M Nakasu, M Saito, T Usuda, R Tsuboi, Y Okubo
A 70-year-old man presented to our clinic with a 10-year history of recurrent pruritic erythema and plaques on his trunk and limbs. Based on the pathological findings and monoclonal rearrangement of the T-cell receptor (TCR)-Cβ1 gene, mycosis fungoides (T2N0M0B0 stage IB) was diagnosed. Despite combination therapy including histone deacetylase inhibitor (vorinostat), the symptoms slowly evolved into Sézary syndrome (SS; T4N1M0B2) over 4 years, with dense infiltrates due to atypical lymphocytes expressing CCR4 developing in the entire dermis...
January 12, 2018: Clinical and Experimental Dermatology
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