Hao Zhang, Yue Xu, Kai Wang, Chaoyue Zheng, Yanfeng Li, Huijie Gong, Changming Liu, Mingxiong Sheng, Qinghua Xu, Yifeng Sun, Jinying Chen, Xiaodong Zhang, Changwen Zhang, Hongxian Zhang, Wei Wang
BACKGROUND: Current approaches for diagnosis and monitoring of upper tract urothelial carcinoma (UTUC) are often invasive, costly, and not efficient for early-stage and low-grade tumors. OBJECTIVE: To validate a noninvasive urine-based RNA test for accurate UTUC diagnosis. DESIGN, SETTING, AND PARTICIPANTS: Urine samples were prospectively collected from 61 patients with UTUC and 99 controls without urothelial carcinomas, in five clinical centers between October 2022 and August 2023 prior to any invasive test (cystoscope or ureteroscope) or treatment...
March 23, 2024: European Urology Oncology