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https://www.readbyqxmd.com/read/29792974/patient-compliance-with-maintenance-intravesical-therapy-for-non-muscle-invasive-bladder-cancer
#1
Shlomi Tapiero, Alexander Helfand, Daniel Kedar, Ofer Yossepowitch, Andrei Nadu, Jack Baniel, David Lifshitz, David Margel
OBJECTIVE: To assess patient adherence to intravesical instillation therapy for non-muscle invasive urothelial carcinoma outside of clinical trials. METHODS: We reviewed the records of patients from 2000-2013 who received intravesical therapy for non-muscle invasive urothelial carcinoma. Patients with evidence of tumor recurrence or progression were excluded. We performed univariable and multivariable regression analysis to predict adherence to intravesical therapy...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29791078/molecular-subtype-classification-of-urothelial-carcinoma-in-lynch-syndrome
#2
Christina Therkildsen, Pontus Eriksson, Mattias Höglund, Mats Jönsson, Gottfrid Sjödahl, Mef Nilbert, Fredrik Liedberg
Lynch syndrome confers an increased risk for urothelial carcinoma (UC). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have to date not been defined in Lynch syndrome-associated urothelial cancer. We aimed to provide a molecular description of Lynch syndrome-associated UC. Thus, Lynch syndrome-associated UC of the upper urinary tract and the urinary bladder were identified in the Danish hereditary non-polyposis colorectal cancer (HNPCC) register and were transcriptionally and immunohistochemically profiled and further related to data from 307 sporadic urothelial carcinomas...
May 23, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29789814/endolymphatic-ethiodized-oil-intranodal-lymphangiography-and-cyanoacrylate-glue-embolization-for-the-treatment-of-postoperative-lymphatic-leak-after-robot-assisted-laparoscopic-pelvic-resection
#3
Hannah Hill, Ravi N Srinivasa, Joseph J Gemmete, Anthony Hage, Jacob Bundy, Jeffrey Forris Beecham Chick
Purpose: To report the approach, technical success, clinical outcomes, complications, and follow-up of ethiodized oil intranodal lymphangiography with cyanoacrylate glue embolization for the treatment of lymphatic leak after robot-assisted laparoscopic pelvic resection. Materials and Methods: Four men with mean age 68.7 ± 14.3 years were treated with ethiodized oil intranodal lymphangiography with cyanoacrylate embolization for postoperative lymphatic leak. Patients underwent either (1) cystoprostatectomy with ileal conduit and bilateral extensive pelvic lymph node dissection for muscle-invasive urothelial carcinoma and presented with postoperative lymphatic ascites ( n  = 2) or (2) prostatectomy with bilateral standard pelvic lymph node dissection for prostate carcinoma and presented with postoperative pelvic lymphoceles ( n  = 2)...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29789781/serum-cystatin-c-level-is-not-a-promising-biomarker-for-predicting-clinicopathological-characteristics-of-bladder-urothelial-tumors
#4
Hui Wang, Lijian Gao, Cuiyu Meng, Nengwang Yu, Feilong Yang, Cong Zhang, Dawei Li, Lei Yan, Hainan Liu, Zhonghua Xu
The role of cystatin C (Cys-C) in tumorigenesis and progression of bladder urothelial tumors (BUT) is still indefinite. We retrospectively collected the clinical information from the records of 425 BUT patients. Pretreatment serum Cys-C levels were compared across the various groups. Then we subgroup the patients with GFR ≥ 90 mg/min/1.73 m2 , to exclude the effects of lower renal function on cystatin C. No statistically significant differences in the levels of serum Cys-C were found among the tumor characteristics (all P > 0...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789419/detection-of-bladder-cancer-via-microfluidic-immunoassay-and-single-cell-dna-copy-number-alteration-analysis-of-captured-urinary-exfoliated-tumor-cells
#5
Anqi Chen, Guanghou Fu, Zhijie Xu, Yukun Sun, Xiaoyi Chen, Kok Suen Cheng, Kuang Hong Neoh, Zhewen Tang, Shifu Chen, Ming Liu, Tanxiao Huang, Yun Dai, Qibo Wang, Jing Jin, Baiye Jin, Ray P S Han
The increasing incidence of bladder cancer (BC) and its high rate of recurrence over a 5-year period necessitate the need for diagnosis and surveillance amelioration. Cystoscopy and urinary cytology are the current tools, and molecular techniques such as BTA stat, NMP22, survivin mRNA, and urovysion FISH have attracted attention, however, they suf-fer from insufficient sensitivity or specificity. We developed a novel microfluidic approach for harvesting intact urinary-exfoliated tumor cells (UETCs), either individually or in clus-ters, in a clean and segregated environment, which is crucial to minimize cross-contamination and misreads...
May 22, 2018: Cancer Research
https://www.readbyqxmd.com/read/29787373/gynecological-organ-involvement-at-robot-assisted-radical-cystectomy-in-females-is-anterior-exenteration-necessary
#6
Michelle Whittum, Ahmed Aly Hussein, Youssef E Ahmed, Hijab Khan, Collin Krasowski, Neil B Huben, Paul R May, Tomoaki Terakawa, Qiang Li, Khurshid A Guru
INTRODUCTION: We aimed to investigate patient and disease variables associated with gynecological organ invasion in females with bladder cancer at the time of robot-assisted radical cystectomy (RARC). METHODS: We conducted a retrospective review of female patients who underwent robot-assisted anterior pelvic exenteration (RAAE) between 2005 and 2016. Patients were divided into two groups: those with gynecological organ involvement at RAAE and those without. Data were reviewed for perioperative and pathological outcomes...
May 14, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29785621/comparison-of-efficacy-and-toxicity-of-second-line-combination-chemotherapy-regimens-in-patients-with-advanced-urothelial-carcinoma
#7
Yuji Takeyama, Minoru Kato, Chikako Nishihara, Takeshi Yamasaki, Taro Iguchi, Satoshi Tamada, Katsuyuki Kuratsukuri, Tatsuya Nakatani
BACKGROUND: The aim of this study was to evaluate the efficacy and toxicities of second-line chemotherapy regimens with docetaxel and gemcitabine (GD), or paclitaxel and gemcitabine (GP) for advanced or metastatic urothelial carcinoma (UC) that did not respond to first-line platinum-based chemotherapy. METHODS: From 2002 to 2017, 78 patients with metastatic UCs that progressed after platinum-based chemotherapy were treated with either GD (n = 41) or GP (n = 37)...
May 21, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29784993/author-correction-strong-associations-between-chromosomal-aberrations-in-blood-lymphocytes-and-the-risk-of-urothelial-and-squamous-cell-carcinoma-of-the-bladder
#8
Hongkun Wang, Ying Wang, Krishna K Kota, Bing Sun, Bhaskar Kallakury, Nabiel N Mikhail, Douaa Sayed, Ahmed Mokhtar, Doaa Maximous, Etemad H Yassin, Scarlett X Sun, Xiaofei Chen, Christopher A Loffredo, Yun-Ling Zheng
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784854/molecular-subtype-specific-immunocompetent-models-of-high-grade-urothelial-carcinoma-reveal-differential-neoantigen-expression-and-response-to-immunotherapy
#9
Ryoichi Saito, Christof C Smith, Takanobu Utsumi, Lisa M Bixby, Jordan Kardos, Sara E Wobker, Kyle G Stewart, Shengjie Chai, Ujjawal Manocha, Kevin Matthew Byrd, Jeffrey S Damrauer, Scott E Williams, Benjamin G Vincent, William Y Kim
High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit differences in underlying tumor biology and can be divided into luminal-like and basal-like subtypes. We describe here the first subtype-specific murine models of bladder cancer and show that Upk3a-CreERT2; Trp53L/L; PtenL/L; Rosa26LSL-Luc (UPPL: luminal-like) and BBN (basal-like) tumors are more faithful to human bladder cancer than the widely-used MB49 cells. Following engraftment into immunocompetent C57BL/6 mice, BBN tumors were more responsive to PD-1 inhibition than UPPL tumors...
May 21, 2018: Cancer Research
https://www.readbyqxmd.com/read/29784744/the-changing-treatment-landscape-for-metastatic-urothelial-carcinoma
#10
Thomas W Flaig
Urothelial carcinoma is the predominant histologic type of bladder cancer. After 30 years of minimal progress in the treatment of advanced-stage disease, recent advances in the genomic characterization of urothelial cancer and breakthroughs in bladder cancer therapeutics have rejuvenated the field. Nivolumab, pembrolizumab, atezolizumab, durvalumab, and avelumab are among the exciting recent novel therapeutic advances gaining approvals by the FDA for treatment of advanced-stage urothelial carcinoma. Yet the challenge for clinicians is to determine the optimal choice of agents as first-line or second-line therapy and which offers the best chance for overall survival for the individual patient in this rapidly changing field...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29784662/ibuprofen-decreases-spontaneous-activity-and-enhances-nerve-evoked-contractions-to-minimise-mitomycin-c-induced-bladder-dysfunction
#11
Eliza G West, Ryan Lang, Donna Sellers, Russ Chess-Williams, Catherine M McDermott
Inflammation may play a causal role in urological side effects reported following intravesical mitomycin C (MMC). Our aim was to investigate the effects of the non-steroidal anti-inflammatory drug ibuprofen (IBU) on the cytotoxic potency of MMC and the potential for IBU to protect against bladder dysfunction. Malignant (RT4, T24) and normal (UROtsa) urothelial lines were treated with MMC followed by ibuprofen, with cell viability and caspase-3 activity assessed. Female C57BL/6JArc mice (Saline/Control, MMC, Saline + IBU and MMC + IBU), received intravesical treatment (1hr) with saline or MMC (2mg/mL), with IBU (1mg/mL) delivered in drinking water (for 7-days)...
May 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29783592/re-efficacy-of-high-intensity-local-treatment-for-metastatic-urothelial-carcinoma-of-the-bladder-a-propensity-score-weighted-analysis-from-the-national-cancer-data-base
#12
https://www.readbyqxmd.com/read/29782018/novel-method-of-plasmid-dna-delivery-to-mouse-bladder-urothelium-by-electroporation
#13
Chuan Yu, Ofir Stefanson, Yueli Liu, Zhu A Wang
Genetically engineered mouse models (GEMMs) are extremely valuable in revealing novel biological insights into the initiation and progression mechanisms of human diseases such as cancer. Transgenic and conditional knockout mice have been frequently used for gene overexpression or ablation in specific tissues or cell types in vivo. However, generating germline mouse models can be time-consuming and costly. Recent advancements in gene editing technologies and the feasibility of delivering DNA plasmids by viral infection have enabled rapid generation of non-germline autochthonous mouse cancer models for several organs...
May 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781067/rare-plasmacytoid-urothelial-carcinoma-of-the-bladder-two-case-reports
#14
Tuba Devrim, Fatih Atac, Canan Altunkaya, Ayse Ozbek, Gulhan Ozdemir, Merve Eryol
Plasmacytoid urothelial carcinoma is a rare and aggressive form of urothelial carcinoma characterized with delayed presentation and poor prognosis. Very few cases of this carcinoma have been reported in the literature. Here, we report and discuss two cases of bladder plasmacytoid urothelial carcinoma of a 57-year-old male presentedwith renal colic, and a 33-year-old female presented with macroscopic hematuria. Pathologic examinations of thetransurethral biopsies revealed urothelial carcinoma with plasmacytoid appearance...
May 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29780656/primary-leiomyosarcoma-of-the-colon-a-report-of-two-cases-review-of-the-literature-and-association-with-immunosuppression-for-ibd-and-rheumatoid-arthritis
#15
Jessica S Crystal, Kristin Korderas, David Schwartzberg, Steven C Tizio, Min Zheng, Glenn Parker
Primary leiomyosarcomas (LMS) of the colon are rare and aggressive neoplasms and have been infrequently reported in the literature. These tumors are more aggressive and have poorer prognoses than adenocarcinoma of the colon and are often mistaken as such on initial evaluation. While the former has a clear association with inflammatory bowel disease (IBD), this correlation is not known to exist with LMS and IBD. Nor is there a known link between LMS and the immunosuppression for IBD, despite the known association between malignancy and immunosuppression for other diseases...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29780413/experience-with-renal-autotransplantation-typical-and-atypical-indications
#16
Ali Bourgi, Rana Aoun, Elias Ayoub, Maroun Moukarzel
Introduction and Objectives: Renal autotransplantation is a kidney-saving surgical procedure used in selected patients. The purpose of this report is to review nine typical and atypical indications for kidney autotransplantation and evaluate its effectiveness in maintaining kidney function and avoiding cancer recurrence. Materials and Methods: From 1999 till 2014, nine renal autotransplantations were performed in our center. A retrospective case review was done...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29777909/lncrnas-as-potential-molecular-biomarkers-for-the-clinicopathology-and-prognosis-of-glioma-a-systematic-review-and-meta-analysis
#17
REVIEW
Qian Zhou, Jing Liu, Jing Quan, Wenlan Liu, Hui Tan, Weiping Li
BACKGROUND: An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in the development of glioma. However, a systematic review and meta-analysis to evaluate the clinical value of lncRNA expression in glioma patients is lacking. We performed this study to assess the relationship between the expression of various lncRNAs and the clinicopathological features, diagnosis and prognosis of glioma. MATERIALS AND METHODS: Eligible studies were identified through a comprehensive literature search...
May 16, 2018: Gene
https://www.readbyqxmd.com/read/29777711/uca1-confers-paclitaxel-resistance-to-ovarian-cancer-through-mir-129-abcb1-axis
#18
Junrong Wang, Cong Ye, Junbao Liu, Yubo Hu
Increasing evidence has demonstrated the involvement of dysregulated long non-coding RNAs (lncRNAs) in chemoresistance acting as potential oncogenes or tumor suppressors in various cancers. Nevertheless, the profound molecular mechanisms of lncRNAs in ovarian cancer (OC) chemoresistance is not well elucidated. The objective of this work was to investigate the role and molecular mechanisms of urothelial carcinoma associated 1 (UCA1) in paclitaxel (PTX) resistance in OC. Our results indicated that UCA1 was significantly up-regulated in PTX-resistant OC cells (SKOV3/PTX and HeyA-8/PTX) compared with their parental cells (SKOV3 and HeyA-8)...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29776013/prognostic-pathologic-factors-in-radical-cystectomy-after-neoadjuvant-chemotherapy
#19
Fadi Brimo, Michelle R Downes, Tamara Jamaspishvili, David Berman, Guliz A Barkan, Daniel Athanazio, Schuharazad Abro, Kash Visram, Asli Yilmaz, Shraddha Solanki, Elan Hahn, Robert Siemens, Wassim Kassouf, Kiril Trpkov
We undertook a systematic evaluation of the prognostic value of numerous histologic factors in 165 radical cystectomies (RC) of patients with invasive urothelial carcinoma who underwent surgery after neoadjuvant chemotherapy (NAC). Tumor regression grade (TRG) and therapy-related stromal and epithelial changes were also recorded. Locally advanced disease (≥pT2 and/or pN+) was present in 64% of patients, 22% had no evidence of residual carcinoma (pT0+pN0) and 28% had no evidence of residual muscle invasive carcinoma (≤pT1+N0)...
May 18, 2018: Histopathology
https://www.readbyqxmd.com/read/29774823/endoscopic-management-of-upper-urinary-tract-urothelial-carcinoma
#20
Patrick Samson, Arthur D Smith, David Hoenig, Zeph Okeke
INTRODUCTION: Endoscopic management of upper tract urothelial carcinoma has become more popular over the last few decades as there has been an impetus for renal preservation in these patients. While radical nephroureterectomy has been the gold standard in treatment of this disease, ureteroscopic and percutaneous management has become a viable option for select patients. METHODS AND MATERIALS: The literature on endoscopic management of upper urinary tract tumors was explored...
May 2018: Journal of Endourology
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