keyword
https://read.qxmd.com/read/38536193/-complications-of-intravesical-bcg-therapy
#1
JOURNAL ARTICLE
Aresh Farokhnia, Silvana K Rampini, Micha Gundelfinger
BCG instillations are considered to be the standard of care therapy for superficial urothelial bladder carcinoma. Although serious adverse events are uncommon, the presence of high fever for at least two days in conjunction with systemic and/or local organ manifestations (except for urogenital symptoms), with the exclusion of other causes, suffice for the diagnosis of a disseminated BCG infection. Microbiologic detection of the pathogen is not necessary for diagnosis, as the detection of granuloma is more often successful and sufficient...
February 2024: Praxis
https://read.qxmd.com/read/38535065/primary-adenosquamous-carcinoma-of-the-prostate
#2
JOURNAL ARTICLE
Roksolana Demianets, Dong Ren, Roozbeh Houshyar, Giovanna A Giannico, Cary Johnson
Prostate cancer accounts for 29% of malignant diagnoses among men in the United States and is the second leading cause of death from cancer. Effective screening methods and improved treatment have decreased the mortality rate significantly. This decreased mortality rate, however, does not apply to all histologic variants. Adenosquamous carcinoma of the prostate is an extremely aggressive neoplasm with no current known curative therapy. It is often diagnosed after chemotherapy, radiation, or androgen deprivation therapy for traditional prostatic adenocarcinomas...
March 19, 2024: Diagnostics
https://read.qxmd.com/read/38534790/the-role-of-urothelial-cancer-associated-1-in-gynecological-cancers
#3
REVIEW
Eleni Nousiopoulou, Kleio Vrettou, Christos Damaskos, Nikolaos Garmpis, Anna Garmpi, Panagiotis Tsikouras, Nikolaos Nikolettos, Konstantinos Nikolettos, Iason Psilopatis
Gynecological cancers (GC) represent some of the most frequently diagnosed malignancies in women worldwide. Long-non-coding RNAs (lncRNAs) are regulatory RNAs increasingly being recognized for their role in tumor progression and metastasis in various cancers. Urothelial cancer-associated 1 (UCA1) is a lncRNA, first found deregulated in bladder cancer, and many studies have exposed its oncogenic effects in more tumors since. However, the role of UCA1 in gynecological malignancies is still unclear. This review aims to analyze and define the role of UCA1 in GC, in order to identify its potential use as a diagnostic, prognostic, or therapeutic biomarker of GC...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534755/increased-apolipoprotein-a1-expression-correlates-with-tumor-associated-neutrophils-and-t-lymphocytes-in-upper-tract-urothelial-carcinoma
#4
JOURNAL ARTICLE
Chih-Chia Chang, Chia-Bin Chang, Chiung-Ju Chen, Chun-Liang Tung, Chi-Feng Hung, Wei-Hong Lai, Cheng-Huang Shen, Chang-Yu Tsai, Ya-Yan Lai, Ming-Yang Lee, Shu-Fen Wu, Pi-Che Chen
An increased neutrophil-to-lymphocyte ratio (NLR) is a poor prognostic biomarker in various types of cancer, because it reflects the inhibition of lymphocytes in the circulation and tumors. In urologic cancers, upper tract urothelial carcinoma (UTUC) is known for its aggressive features and lack of T cell infiltration; however, the association between neutrophils and suppressed T lymphocytes in UTUC is largely unknown. In this study, we examined the relationship between UTUC-derived factors and tumor-associated neutrophils or T lymphocytes...
March 7, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38532369/preliminary-findings-on-the-development-of-a-predictive-model-for-blca-based-on-disulfidptosis-associated-incrnas-signature
#5
JOURNAL ARTICLE
Chao Tang, Yanpeng Fan, Shusheng Zhu
BACKGROUND: Bladder urothelial carcinoma (BLCA) is the most common malignancy of the urinary tract, presenting with a wide range of clinical symptoms and prognosis. Disulfidptosis is a newly identified cell death method and closely associated with BLCA progression, prognosis, and treatment outcome. Currently, we need to construct a new prognostic model for disulfidptosis-related long noncoding RNAs (drlncRNAs) to improve the treatment strategy of BLCA. METHODS: The data for BLCA samples were obtained from The Cancer Genome Atlas (TCGA), and then 10 unique genes related to disulfidoptosis (DRGs) were identified from research papers...
March 26, 2024: BMC Urology
https://read.qxmd.com/read/38532363/quantitative-differentiation-of-non-invasive-bladder-urothelial-carcinoma-and-inverted-papilloma-based-on-ct-urography
#6
JOURNAL ARTICLE
Pengfei Jin, Liqin Yang, Yitao Liu, Jiehui Huang, Xu Wang
PURPOSE: To investigate the value of CT urography (CTU) indicators in the quantitative differential diagnosis of bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB). MATERIAL AND METHODS: The clinical and preoperative CTU imaging data of continuous 103 patients with histologically confirmed BUC or IPB were retrospectively analyzed. The imaging data included 6 qualitative indicators and 7 quantitative measures. The recorded clinical information and imaging features were subjected to univariate and multivariate logistic regression analysis to find independent risk factors for BUC, and a combined multi-indicator prediction model was constructed, and the prediction model was visualized using nomogram...
March 26, 2024: BMC Urology
https://read.qxmd.com/read/38531343/adjuvant-chemotherapy-after-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-with-variant-histology-a-systematic-review-and-meta-analysis-of-survival-outcomes
#7
Jinhyung Jeon, Jae Heon Kim, Jee Soo Ha, Won Jae Yang, Kang Su Cho, Do Kyung Kim
INTRODUCTION: To determine effects of adjuvant chemotherapy (AC) on survival outcomes compared to surgery alone without AC for upper tract urothelial carcinoma (UTUC) patients with variant histology (VH). METHODS: We conducted a systematic review and meta-analysis of studies investigating AC for UTUC in Medline, Embase, the Cochrane library up to January 2023. Population, intervention, comparator, and outcome were UTUC patients with VH, radical nephroureterectomy with AC, radical nephroureterectomy only, and oncological survival, respectively...
March 26, 2024: Urologia Internationalis
https://read.qxmd.com/read/38531255/on-relevant-features-for-the-recurrence-prediction-of-urothelial-carcinoma-of-the-bladder
#8
JOURNAL ARTICLE
Louisa Schwarz, Dominik Sobania, Franz Rothlauf
BACKGROUND: Urothelial bladder cancer (UBC) is characterized by a high recurrence rate, which is predicted by scoring systems. However, recent studies show the superiority of Machine Learning (ML) models. Nevertheless, these ML approaches are rarely used in medical practice because most of them are black-box models, that cannot adequately explain how a prediction is made. OBJECTIVE: We investigate the global feature importance of different ML models. By providing information on the most relevant features, we can facilitate the use of ML in everyday medical practice...
March 18, 2024: International Journal of Medical Informatics
https://read.qxmd.com/read/38530492/prediction-of-pathological-up-staging-after-radical-nephroureterectomy-in-patients-with-upper-tract-urothelial-carcinoma
#9
JOURNAL ARTICLE
Kazunori Shojo, Toshikazu Takeda, Hirotaka Akita, Tatsuya Suzuki, Shuji Mikami, Keisuke Shigeta, Yota Yasumizu, Nobuyuki Tanaka, Kazuhiro Matsumoto, Shinya Morita, Takeo Kosaka, Ryuichi Mizuno, Hiroshi Asanuma, Masahiro Jinzaki, Mototsugu Oya
PURPOSE: The diagnostic accuracy of computed tomography urography for upper tract urothelial carcinoma is high; however, difficulties are associated with precisely assessing the T stage. Preoperative tumor staging has an impact on treatment options for upper tract urothelial carcinoma. We herein attempted to identify preoperative factors that predict pathological tumor up-staging, which will facilitate the selection of treatment strategies. MATERIALS AND METHODS: We retrospectively identified 148 patients with upper tract urothelial carcinoma who underwent computed tomography urography preoperatively followed by radical nephroureterectomy without preoperative chemotherapy at our institution between 2000 and 2021...
March 26, 2024: World Journal of Urology
https://read.qxmd.com/read/38527985/endothelial-cell-proliferation-and-vascular-patterns-in-urothelial-carcinoma
#10
JOURNAL ARTICLE
Tiberiu Gabriel Adelmann, Amalia Raluca Ceauşu, Nela Puşa Gaje, Marius Raica
INTRODUCTION: The bladder cancer has some characteristics: the sixth most incident neoplasm in the United States, the majority of diagnosed cases in those 55 years of age and older, four times more common in man than women, a reduced five-year survival rate in case of metastatic disease. Despite the beneficial effects of the combination therapy and immunotherapy, the low response rate and drug resistance were reported. The main goal of this work was evaluation of the endothelial cell proliferation from urothelial carcinomas...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527321/parastomal-hernia-following-ileal-conduit-incidence-risk-factors-and-health-related-quality-of-life
#11
JOURNAL ARTICLE
Xinyan Che, Haiwen Huang, Wei Wang, Lijun Zhong, Shuhui Yu, Yanbo Huang, Zhijun Xi
PURPOSE: The purpose of this study was to measure the incidence of parastomal hernia (PH) after radical cystectomy and ileal conduit. Secondary aims were the identification of risk factors for PH and to compare the health-related quality of life (QOL) between patients with and without PH. DESIGN: Retrospective review of medical records combined with cross-sectional administration of the QOL instrument and telephone follow-up. SUBJECTS AND SETTING: The study sample comprised 219 patients who underwent radical cystectomy and ileal conduit for urothelial cancer between February 2014 and December 2018...
March 2024: Journal of Wound, Ostomy, and Continence Nursing
https://read.qxmd.com/read/38526412/initial-experience-and-clinical-assessment-of-the-karl-storz-flex-xc1-single-use-flexible-ureteroscope
#12
JOURNAL ARTICLE
Jamal Alamiri, Robert Qi, Kevin F Hanna, Lindsay A White, Garrett N Ungerer, Jayson P Kemble, Carly A Thompson, Aaron M Potretzke, Kevin Koo
INTRODUCTION: The Karl Storz FLEX-XC1 is a novel single-use flexible ureteroscope that uses the same videographics platform as its reusable digital counterpart. We evaluated the technical performance of the FLEX-XC1 in its initial clinical use. METHODS: We reviewed a series of consecutive ureteroscopy procedures performed by 2 endourologists using the FLEX-XC1 for indications for which we typically use a single-use device: total stone burden >15 mm or >10 mm in the lower pole, anticipated case duration >60 minutes, bilateral procedure, or upper tract urothelial cancer procedures...
March 13, 2024: Urology Practice
https://read.qxmd.com/read/38526374/objective-evaluation-of-gaze-location-patterns-using-eye-tracking-during-cystoscopy-and-artificial-intelligence-assisted-lesion-detection
#13
JOURNAL ARTICLE
Atsushi Ikeda, Kazuya Izumi, Kensuke Katori, Hirokazu Nosato, Keita Kobayashi, Shuhei Suzuki, Shuya Kandori, Masaru Sanuki, Yoichi Ochiai, Hiroyuki Nishiyama
BACKGROUND: The diagnostic accuracy of cystoscopy varies according to the knowledge and experience of the performing physician. Here, we evaluated the difference in cystoscopic gaze location patterns between medical students and urologists and assessed the differences in their eye movements when simultaneously observing conventional cystoscopic images and images with lesions detected by artificial intelligence (AI). METHODOLOGY: Eye-tracking measurements were performed, and observation patterns of participants (24 medical students and 10 urologists) viewing images from routine cystoscopic videos were analyzed...
March 25, 2024: Journal of Endourology
https://read.qxmd.com/read/38524674/unusual-presentation-of-internal-hernia-after-robot-assisted-radical-cystectomy
#14
Lucio Dell'Atti
Here is presented the first case of internal hernia developing from the space between ureter and muscle fascia after robot-assisted radical cystectomy with uretero-cutaneostomy diversion. An 82-year-old man underwent robot-assisted radical cystectomy with uretero-cutaneostomy diversion for high-grade urothelial carcinoma (pT2). On the Postoperative Day 7, the patient presented abdominal pain and nausea. Abdominal computed tomography showed that a part of the small intestine was protruding between the right ureter and the transverse fascia, and was strangulated, causing an obstruction of the intestine...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38523920/carcinomatous-meningitis-and-hydrocephalus-in-plasmacytoid-urothelial-carcinoma-of-the-urinary-bladder-with-extremely-elevated-ca19-9-levels
#15
Fumiaki Henmi, Kayako Ukai, Atsuhito Nakayama, Yutaka Takazawa, Yoshikazu Uesaka
This case report describes a rare and aggressive presentation of plasmacytoid urothelial carcinoma (PUC) with carcinomatous meningitis, hydrocephalus, extensive organ involvement, and extremely elevated serum CA19-9 levels. Autopsy findings revealed that PUC of the urinary bladder origin caused carcinomatous meningitis and hydrocephalus, with exacerbation of hydrocephalus as the direct cause of death. Immunohistochemical studies confirmed the bladder origin of PUC, and PUC cells were positive for CA19-9, a tumor marker commonly associated with gastrointestinal malignancies, suggesting that the markedly high serum CA19-9 level was related to the tumor-producing mechanism...
February 2024: Curēus
https://read.qxmd.com/read/38523833/a-curious-case-concurrent-collecting-duct-renal-cell-carcinoma-and-upper-tract-urothelial-carcinoma
#16
Adib Rahman, Daniel Matheson, Joanna Perry-Keene, Devang Desai
A 71-year-old male presented to Urology with three weeks of overt haematuria and increasing lethargy. Contrast-enhanced CT scans revealed an 8 × 6cm partially exophytic lesion in the left kidney's upper pole, extending beyond the capsule and invading the superior cortical vein, accompanied by abnormal retrocrural lymph nodes. Signs of paraneoplastic syndrome prompted a left radical nephrectomy for symptom relief. Histological analysis identified high-grade collecting duct renal carcinoma and invasive urothelial cell carcinoma...
May 2024: Urology Case Reports
https://read.qxmd.com/read/38523484/updates-on-urinary-bladder-tumors-with-neuroendocrine-features
#17
JOURNAL ARTICLE
Dilara Akbulut, Hikmat Al-Ahmadie
The most common neuroendocrine tumor in the urinary bladder is small cell carcinoma, which can be pure or mixed with components of urothelial or other histologic subtypes. Large cell neuroendocrine carcinoma of the bladder is rare and remains ill-defined but is increasingly recognized. Well-differentiated neuroendocrine tumor and paraganglioma can arise in the bladder but are very rare in this location. Recent advances in molecular characterization allowed for better classification and may offer improved stratification of these tumors...
March 25, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38523233/immunochemistry-based-quantification-of-tumor-infiltrating-lymphocytes-and-immunoscore-as-prognostic-biomarkers-in-bladder-cancer
#18
JOURNAL ARTICLE
Sarra Ben Rejeb, Sirine Elfekih, Nadia Kouki, Rami Boulma, Hassen Khouni
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) and the derived immunoscore (IS) have gained considerable attention over the last decade as prognostic markers in many solid cancers. However, in bladder cancer (BC), their prognostic value is not clearly established. METHODS: The present study aimed to quantify the TILs rates in BC, assess the derived immunoscore, and investigate their prognostic value. An immunochemistry-based quantification of the different subtypes of TILS was performed on paraffin-embedded blocks from patients with invasive urothelial carcinoma of the bladder...
March 25, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38523018/large-scale-prospective-validation-study-of-a-multiplex-rna-urine-test-for-noninvasive-detection-of-upper-tract-urothelial-carcinoma
#19
JOURNAL ARTICLE
Hao Zhang, Yue Xu, Kai Wang, Chaoyue Zheng, Yanfeng Li, Huijie Gong, Changming Liu, Mingxiong Sheng, Qinghua Xu, Yifeng Sun, Jinying Chen, Xiaodong Zhang, Changwen Zhang, Hongxian Zhang, Wei Wang
BACKGROUND: Current approaches for diagnosis and monitoring of upper tract urothelial carcinoma (UTUC) are often invasive, costly, and not efficient for early-stage and low-grade tumors. OBJECTIVE: To validate a noninvasive urine-based RNA test for accurate UTUC diagnosis. DESIGN, SETTING, AND PARTICIPANTS: Urine samples were prospectively collected from 61 patients with UTUC and 99 controls without urothelial carcinomas, in five clinical centers between October 2022 and August 2023 prior to any invasive test (cystoscope or ureteroscope) or treatment...
March 23, 2024: European Urology Oncology
https://read.qxmd.com/read/38522975/testing-the-external-validity-of-the-pout-iii-trial-adjuvant-platnium-based-chemotherapy-in-upper-tract-urothelial-carcinoma-in-a-north-american-cohort
#20
JOURNAL ARTICLE
Nicholas James Corsi, Alex Stephens, Marco Finati, Taylor Malchow, Chase Morrison, Matthew Davis, Keinnan Hares, Matthew P Corsi, Sohrab Arora, Giuseppe Chiarelli, Giuseppe Ottone Cirulli, Riccardo Autorino, Akshay Sood, Craig Rogers, Firas Abdollah
OBJECTIVE: The European POUT III randomized controlled trial provided level-one evidence that adjuvant platinum-based chemotherapy is the standard of care following nephroureterectomy (RNU) for locally invasive or node-positive upper tract urothelial carcinoma. We aim to assess this European randomized controlled trial's generalizability (external validity) to a North American cohort, using a nationwide database. MATERIALS AND METHODS: To compare trial patients with those seen in real-world practice, we simulated the trial inclusion criteria using data from the National Cancer Database (NCDB)...
March 23, 2024: Urologic Oncology
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