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https://www.readbyqxmd.com/read/27920687/a-case-of-primary-small-cell-carcinoma-of-the-bladder
#1
Ashita Ono, Yosuke Hirasawa, Mitsumasa Yamashina, Naoto Kaburagi, Takashi Mima, Toru Sugihara, Riu Hamada, Tatsuo Gondo, Makoto Ohori, Toshitaka Nagao, Yoshio Ohno
Primary small-cell carcinoma arising from the bladder (SmCCB) is uncommon. It differs from urothelial carcinoma (UC), the most common type of bladder cancer, with respect to its cell of origin, biology, and prognosis. Biologically, prostatic SmCCB is much more aggressive than UC, and the prognosis for cases with distant metastasis is especially poor. We report here a case of primary SmCCB (cT3bN1M0) treated with radical cystectomy.
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27920099/systematic-regional-lymph-node-dissection-for-upper-tract-urothelial-carcinoma-improves-patient-survival
#2
Hiroshi Furuse, Yuto Matsushita, Takashi Yajima, Taiki Kato, Takahisa Suzuki, Rikiya Matsumoto, Daisuke Motoyama, Takayuki Sugiyama, Atsushi Otsuka, Seiichiro Ozono
OBJECTIVE: Unlike for bladder cancer, the impact of regional lymph node dissection for upper tract urothelial carcinoma is unclear. We explored whether patient survival was influenced by systematic regional lymph node dissection, using resection templates according to the main tumor location, during radical nephroureterectomy for upper tract urothelial carcinoma. METHODS: The systematic regional lymph node dissection group was defined as cases in which the dissection of nodes and surrounding tissues followed the established template, and the non-systematic regional lymph node dissection group as cases undergoing limited or no lymph node dissection...
December 4, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27919942/a-single-intravesical-instillation-of-vax014-inhibits-orthotopic-superficial-bladder-tumor-implantation-to-increase-survival
#3
Bryan M Hancock, Kathleen L McGuire, Shingo Tsuji, Katherine Reil, Veronica Hernandez, Matthew J Giacalone, W T Godbey
BACKGROUND/AIM: VAX014 minicells (VAX014) have been previously characterized as an integrin-specific oncolytic biotherapeutic agent. The present study was designed to evaluate the potential of VAX014 as an immediate post-operative intravesical adjuvant therapy in the treatment of non-muscle invasive bladder cancer (NMIBC). MATERIALS AND METHODS: The ability of VAX014 to kill a panel of dissociated urothelial carcinoma cell lines was tested in vitro. In vivo experiments were conducted using a single intravesical dose of VAX014 in the anti-implantation variation of the MB49 syngeneic orthotopic bladder cancer model with tumor implantation and overall survival rates serving as study endpoints...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919128/-ipsilateral-occurrence-of-renal-pelvic-carcinoma-after-partial-nephrectomy-for-renal-cell-carcinoma
#4
Tomoyuki Tatenuma, Nobuhiko Mizuno, Ryosuke Jikuya, Masaki Kawai, Takeshi Kishida
A 70-year-old man underwent left partial nephrectomy for renal cell carcinoma (pT1aN0M0). One year after the surgery, he presented with hematuria and fatigue. Computed tomography showed a left 8 cm renal tumor and multiple liver and lung metastases. We performed percutaneous renal and liver biopsy with echo guidance. The diagnosis of both kidney and liver was urothelial carcinoma. He died 3 weeks after the diagnosis. Ipsilateral occurrence of the pelvic renal carcinoma after partial nephrectomy for renal cell carcinoma is extremely rare...
October 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27918099/mir-193b-mediates-cebpd-induced-cisplatin-sensitization-through-targeting-ets1-and-cyclin-d1-in-human-urothelial-carcinoma-cells
#5
Siao-Ren Lin, Hsin-Chih Yeh, Wei-Jan Wang, Hung-Lung Ke, Hui-Hui Lin, Wei-Chi Hsu, Shi-Yi Chao, Tzyh-Chyuan Hour, Wen-Jeng Wu, Yeong-Shiau Pu, A-Mei Huang
Transcription factor CCAAT/enhancer-binding protein delta (CEBPD) plays multiple roles in tumor progression. Studies have demonstrated that cisplatin (CDDP) induced CEBPD expression and had led to chemotherapeutic drug resistance. However, the underlying molecular mechanisms of CDDP-regulated CEBPD expression and its relevant roles in CDDP responses remain elusive. MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression in a sequence-specific manner. Abnormal miRNAs expression is associated with tumor progression...
December 5, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27915472/pathomechanism-of-interstitial-cystitis-bladder-pain-syndrome-and-mapping-the-heterogeneity-of-disease
#6
REVIEW
Jia-Fong Jhang, Hann-Chorng Kuo
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a heterogeneous syndrome which is usually characterized by urinary frequency, nocturia, and bladder pain. Several pathomechanisms have been proposed, including uroepithelial dysfunction, mast cell activation, neurogenic inflammation, autoimmunity, and occult urinary tract infections. It is possible that an inflammatory process alters regulation of urothelial homeostasis and results in dysfunction of the bladder epithelium. Different phenotypes of IC/BPS have been explored including Hunner and non-Hunner type IC, hypersensitive bladder, and bladder pain both with and without functional somatic syndrome...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27913867/comparison-of-different-concepts-for-interpretation-of-chromosomal-aberrations-in-urothelial-cells-detected-by-fluorescence-in-situ-hybridization
#7
Johannes Mischinger, Lutz Philipp Guttenberg, Jörg Hennenlotter, Georgios Gakis, Stefan Aufderklamm, Steffen Rausch, Eva Neumann, Jens Bedke, Stefan Kruck, Christian Schwentner, Arnulf Stenzl, Tilman Todenhöfer
PURPOSE: Urine fluorescence in situ hybridization (FISH) has become a broadly used marker for noninvasive detection of bladder cancer (BC). However, it has been discussed whether the interpretation algorithm proposed by the manufacturer could be improved. Aim of the present study was to compare alternative evaluation strategies of FISH for detection of BC. METHODS: We included 1048 patients suspicious for BC, who underwent urine FISH examination before cystoscopy (diagnostic cohort)...
December 2, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27913307/urothelium-adherent-ion-triggered-liposome-in-gel-system-as-a-platform-for-intravesical-drug-delivery
#8
Shruti GuhaSarkar, Prachi More, Rinti Banerjee
Instillations of therapeutic agents into the urinary bladder have limited efficacy due to drug washout and inadequate attachment to and penetration into the bladder wall. Instilled nanoparticles alone have low stability and high susceptibility to washout, while gel-based systems are difficult to administer and retain. To overcome disadvantages of current technologies, a biodegradable, in situ-gelling liposome-in-gel (LP-Gel) system was developed for instillation into the bladder, composed of nano-sized, fluidizing liposomes incorporated into a "smart" biopolymeric, urine-triggered hydrogel...
November 29, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27912971/efficacy-of-systemic-chemotherapy-plus-radical-nephroureterectomy-for-metastatic-upper-tract-urothelial-carcinoma
#9
Thomas Seisen, Tarun Jindal, Patrick Karabon, Akshay Sood, Joaquim Bellmunt, Morgan Rouprêt, Jeffrey J Leow, Malte W Vetterlein, Maxine Sun, Shaheen Alanee, Toni K Choueiri, Quoc-Dien Trinh, Mani Menon, Firas Abdollah
: Given the growing body of evidence supporting the benefit of primary tumor control for a wide range of metastatic malignancies, we hypothesized that chemotherapy plus radical nephroureterectomy (RNU) is associated with an overall survival (OS) benefit compared to chemotherapy alone for metastatic upper tract urothelial carcinoma (mUTUC). Within the National Cancer Data Base (2004-2012), we identified 398 (38.4%) and 637 (61.6%) patients who received chemotherapy plus RNU and chemotherapy alone, respectively...
November 29, 2016: European Urology
https://www.readbyqxmd.com/read/27912839/-urothelial-tumors-in-2016-are-we-at-the-dawn-of-a-new-diagnostic-and-therapeutic-era
#10
EDITORIAL
Christian Pfister
No abstract text is available yet for this article.
December 2016: Annales de Pathologie
https://www.readbyqxmd.com/read/27910890/adjuvant-radiotherapy-for-locally-advanced-upper-tract-urothelial-carcinoma
#11
Yun-Ching Huang, Ying-Hsu Chang, Kuo-Hsiung Chiu, Alan W Shindel, Chia-Hsuan Lai
There is relatively little literature on adjuvant radiotherapy after radical nephroureterectomy with bladder cuff excision (RNU) for patients with upper tract urothelial carcinoma (UTUC). This study was designed to determine the efficacy of adjuvant radiotherapy for patients with pT3N0M0 UTUC. We retrospectively reviewed 198 patients treated with RNU between December 2001 and January 2015. Postoperative radiotherapy was administered in 40 (20.2%) of patients. Patients who received radiotherapy were younger than those that did not (65...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908680/the-effect-of-contralateral-kidney-volume-on-renal-function-after-radical-nephroureterectomy-implications-for-eligibility-for-neoadjuvant-chemotherapy-for-upper-tract-urothelial-cancer
#12
Wan Song, Hyun Hwan Sung, Deok Hyun Han, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Hwang Gyun Jeon
PURPOSE: We investigated the effect of preoperative contralateral kidney (CK) volume on renal function after radical nephroureterectomy (RNU). METHODS: We reviewed 630 patients who underwent RNU between September 1994 and December 2013. Of these 630 patients, 135 patients with advanced upper tract urothelial cancer were ultimately included. Preoperative CK volume was measured from computed tomography images of the venous phase using a specialized volumetric program...
November 28, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27906675/preoperative-serum-pre-albumin-as-an-independent-prognostic-indicator-in-patients-with-localized-upper-tract-urothelial-carcinoma-after-radical-nephroureterectomy
#13
Jiwei Huang, Yanqing Wang, Yichu Yuan, Yong-Hui Chen, Wen Kong, Haige Chen, Jin Zhang, Yiran Huang
PURPOSE: To investigate the prognostic value of preoperative pre-albumin and albumin level in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy. METHODS AND MATERIALS: Between January 2003 and June 2013, we evaluated data on 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent radical nephroureterectomy at our institution. Low pre-albumin level was defined as <20 mg/dl, while hypoalbuminemia was defined as albumin <35 g/L...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27905300/intravital-imaging-of-mouse-urothelium-reveals-activation-of-extracellular-signal-regulated-kinase-by-stretch-induced-intravesical-release-of-atp
#14
Takeshi Sano, Takashi Kobayashi, Hiromitsu Negoro, Atsushi Sengiku, Takuya Hiratsuka, Yuji Kamioka, Louis S Liou, Osamu Ogawa, Michiyuki Matsuda
To better understand the roles played by signaling molecules in the bladder, we established a protocol of intravital imaging of the bladder of mice expressing a Förster/fluorescence resonance energy transfer (FRET) biosensor for extracellular signal-regulated kinase (ERK), which plays critical roles not only in cell growth but also stress responses. With an upright two-photon excitation microscope and a vacuum-stabilized imaging window, cellular ERK activity was visualized in the whole bladder wall, from adventitia to urothelium...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27902466/long-non-coding-rna-urothelial-carcinoma-associated-1-uca1-mediates-radiation-response-in-prostate-cancer
#15
Alireza Fotouhi Ghiam, Samira Taeb, Xiaoyong Huang, Vincent Huang, Jessica Ray, Seville Scarcello, Christianne Hoey, Sahar Jahangiri, Emmanouil Fokas, Andrew Loblaw, Robert G Bristow, Danny Vesprini, Paul Boutros, Stanley K Liu
Radioresistance remains a significant obstacle in the treatment of Prostate Cancer (PCa). To simulate the clinical scenario of irradiation resistance (IRR), we created DU145-IRR PCa cell lines by treatment with 2 Gy daily IR for 59 fractions. DU145-IRR cells acquired an aggressive phenotype as evidenced by increased clonogenic survival, tumorigenic potential and invasiveness. We performed transcriptome profiling to discover dysregulated genes in DU145-IRR cells and identified the long non-coding RNA (lncRNA), Urothelial carcinoma-associated 1 (UCA1)...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901490/prognostic-value-of-preoperative-plasma-fibrinogen-level-and-platelet-to-lymphocyte-ratio-f-plr-in-patients-with-localized-upper-tract-urothelial-carcinoma
#16
Jiwei Huang, Yichu Yuan, Yanqing Wang, Jin Zhang, Wen Kong, Haige Chen, Yonghui Chen, Yiran Huang
PURPOSE: Hemostatic factors is thought to have a potentially significant role in progression and metastasis of malignant tumors. We investigated the prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (PLR) in localized upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: A total of 481 patients who underwent radical nephroureterectomy for localized UTUC (pTa-4N0M0) were identified between January 2002 and June 2013...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900539/seom-clinical-guideline-for-treatment-of-muscle-invasive-and-metastatic-urothelial-bladder-cancer-2016
#17
M Lázaro, E Gallardo, M Doménech, Á Pinto, A González Del Alba, J Puente, O Fernández, A Font, N Lainez, S Vázquez
The goal of this article is to provide recommendations for the diagnosis and treatment of muscle-invasive and metastatic bladder cancer. The diagnosis of muscle-invasive bladder cancer is made by pathologic evaluation after transurethral resection. Recently, a molecular classification has been proposed. Staging of muscle-invasive bladder cancer must be done by computed tomography scans of the chest, abdomen and pelvis and classified on the basis of UICC system. Radical cystectomy and lymph node dissection are the treatment of choice...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27900023/synchronous-papillary-urothelial-carcinoma-of-the-bladder-and-squamous-cell-carcinoma-with-sarcomatoid-differentiation-a-case-report
#18
Mahizer Yaldiz, Nur Cihan Cosansu, Berna Solak, Zeynep Kahyaoglu, Mustafa Teoman Erdem
The incidence rate of multiple primary tumors is 37% in all types of cancer. A patient diagnosed with primary cancer is 1.29 times more likely to develop an additional primary cancer when compared with the general population. Furthermore, in patients diagnosed with primary cancer, the possibility of a secondary malignancy in the same or different organ is increased. Following the identification of a secondary tumor, the risk of relapse or metastasis must be considered. The present study reports the case of a 76-year-old man who was admitted to Sakarya University Training and Research Hospital (Sakarya, Turkey) with swelling of the head, which had been apparent for 15 days...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899041/electromagnetic-and-electrohydraulic-shock-wave-lithotripsy-induced-urothelial-damage-is-there-a-difference
#19
Mahmoud Mustafa, Honood Aburas, Fatema Helo, Laila Qarawi
PURPOSE: To evaluate and compare the acute effect of electromagnetic and electrohydraulic extracorporeal shock wave lithotripsy (SWL) on the urothelial layers of kidney and ureter. MATERIALS AND METHODS: Fifty patients (29 males (58%), 21 females (42%), with average age 51.68 years (range: 37-70) who underwent SWL application in two different centers were included. Twenty-eight patients (56%) were treated with electrohydraulic and 22 (44%) were treated with electromagnetic lithotripsy...
November 29, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27898096/on-a-fox-hunt-functions-of-fox-transcriptional-regulators-in-bladder-cancer
#20
REVIEW
Hironobu Yamashita, Vasty Osei Amponsa, Joshua I Warrick, Zongyu Zheng, Peter E Clark, Jay D Raman, Xue-Ru Wu, Cathy Mendelsohn, David J DeGraff
Genomic and transcriptional studies have identified discrete molecular subtypes of bladder cancer. These observations could be the starting point to identify new treatments. Several members of the forkhead box (FOX) superfamily of transcription factors have been found to be differentially expressed in the different bladder cancer subtypes. In addition, the FOXA protein family are key regulators of embryonic bladder development and patterning. Both experimental and clinical data support a role for FOXA1 and FOXA2 in urothelial carcinoma...
November 29, 2016: Nature Reviews. Urology
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