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Nephrolithiasis

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https://www.readbyqxmd.com/read/29457022/a-case-report-of-compound-heterozygous-cyp24a1-mutations-leading-to-nephrolithiasis-successfully-treated-with-ketoconazole
#1
Emma Davidson Peiris, Raghav Wusirika
CYP24A1 is an enzyme that inactivates vitamin D. Loss-of-function mutations in this enzyme are rare but have been linked with idiopathic infantile hypercalcemia as well as adult-onset nephrocalcinosis and nephrolithiasis. Genetic testing for this mutation should be considered in the presence of calciuria, elevated serum calcium, elevated 1,25-dihydroxyvitamin D, and suppressed parathyroid hormone. We present a case with these lab findings as well as an elevated 25-hydroxyvitamin D/24,25-dihydroxyvitamin D ratio in whom compound heterozygous CYP24A1 mutations were found...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29450733/miniaturised-percutaneous-nephrolithotomy-versus-flexible-ureteropyeloscopy-a-systematic-review-and-meta-analysis-comparing-clinical-efficacy-and-safety-profile
#2
REVIEW
N F Davis, M R Quinlan, C Poyet, N Lawrentschuk, D M Bolton, D Webb, G S Jack
PURPOSE: This study aims to comparatively evaluate clinical outcomes of mini-PCNL and FURS for treating urinary tract calculi in a single session. METHODS: A systematic search using electronic databases was performed for studies comparing mini-PCNL and FURS for the treatment of urinary tract calculi. The primary outcome measurements were stone-free rates (SFRs) and complication rates for both techniques. Secondary outcome measurements were to compare patient demographics, operative duration, and inpatient stay...
February 16, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29444579/-quality-of-nephrolithiasis-surgical-treatment-what-is-it-influenced-by
#3
V Kováčik, M Maciak, P Bujdák, V Baláž, R Školka, M Rusňák
INTRODUCTION: Identifying factors effecting the quality of nephrolithiasis surgical treatment could improve medical care for patients suffering from kidney stone disease. The objective of the article is to identify factors influencing reintervention rate after surgical treatment of kidney stone disease either by percutaneous nephrolitholapaxy or flexible ureterorenoscopy. METHOD: A retrospective study was conducted on 149 patients who underwent a surgery for a kidney stone disease at the Urological department of F...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29435125/inhibition-of-autophagy-attenuated-calcium-oxalate-crystal-induced-renal-tubular-epithelial-cell-injury-in-vivo-and-in-vitro
#4
Yunlong Liu, Derong Li, Ziqi He, Quan Liu, Jihua Wu, Xiaofeng Guan, Zhiwei Tao, Yaoliang Deng
Accumulating evidence suggests that autophagy is involved in the pathophysiological processes of kidney diseases. However, the role of autophagy in the formation of calcium oxalate (CaOx) nephrolithiasis remains unclear. In this study, we investigated the effects of autophagy on renal tubular epithelial cell injury induced by CaOx crystals in vivo and in vitro . We first observed that the expression levels of LC3-II and BECN1 and number of autophagic vacuoles were markedly increased in the renal tissue of CaOx stone patients...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434367/stones-individual-gut-microbiome-in-nephrolithiasis
#5
Rebecca Kelsey
No abstract text is available yet for this article.
February 13, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29428569/a-continuum-of-mineralization-from-human-renal-pyramid-to-stones-on-stems
#6
Benjamin A Sherer, Ling Chen, Misun Kang, Alex R Shimotake, Scott V Wiener, Tom Chi, Marshall L Stoller, Sunita P Ho
The development of new modalities for kidney stone prevention rests upon understanding the progression of mineralization within the renal pyramid. The progression from small foci of mineralization within the renal pyramid to larger interstitial plaques that ultimately lead to the formation of clinically detectable calcium-based stones on calcium phosphate stems will be presented through correlative microscopy approach. High resolution X-ray computed tomography (micro-XCT), electron microscopy, and energy dispersive X-ray (EDX) compositional analyses of interstitial plaques, stems, and attached stones were performed...
February 8, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29427476/the-accuracy-and-prognostic-value-of-point-of-care-ultrasound-for-nephrolithiasis-in-the-emergency-department-a-systematic-review-and-meta-analysis
#7
Charles Wong, Braden Teitge, Marshall Ross, Paul Young, Helen Lee Robertson, Eddy Lang
INTRODUCTION: Point-of-care ultrasound (POCUS) has been suggested as an initial investigation in the management of renal colic. Our objectives were: 1) to determine the accuracy of POCUS for the diagnosis of nephrolithiasis, and 2) to assess its prognostic value in the management of renal colic. METHODS: The review protocol was registered to the PROSPERO database (CRD42016035331). An electronic database search of MEDLINE, EMBASE, and PubMed was conducted utilizing subject headings, keywords, and synonyms that address our research question...
February 10, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29422481/investigation-of-adipose-tissue-fatty-acid-composition-in-men-with-uronephrolithiasis-and-metabolic-syndrome
#8
Inga Bikulčienė, Laima Vasiliauskaitė, Zita Aušrelė Kučinskienė, Arvydas Kaminskas, Vaiva Hendrixson
BACKGROUND Fatty acids (FA) and their metabolites are closely related to some mechanisms involved in the development of uronephrolithiasis. The aim of this study was to evaluate the relationship between FA composition and type of kidney stones. MATERIAL AND METHODS Abdominal adipose tissue fatty acid methyl esters of 71 men with nephrolithiasis were identified by GC/MS, and the type of kidney stones was identified using FTIR infrared spectroscopy. Patients were divided into groups according to diagnosis of metabolic syndrome (MS) and type of kidney stone...
February 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29421922/pediatric-ureteroscopy
#9
Patrick Fox, Michael C Ost
In recent years, the incidence of nephrolithiasis in the pediatric population appears to be increasing.1 This has placed a new emphasis on surgical management of stones in children. In the past, extra-corporeal shockwave lithotripsy (ESWL) was the preferred management technique for stones in children.2 More recently, though, advances in endoscopy have allowed ureteroscopy to be adapted to the pediatric population and this approach has become more frequently utilized not just for lower ureteral calculi but also for proximal ureteral and renal stones...
February 8, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29421773/study-of-urine-composition-of-patients-with-recurrent-nephrolithiasis-in-lorestan-iran
#10
Babak Hadian, Azita Zafar-Mohtashami, Fershteh Ghorbani
INTRODUCTION: Nephrolithiasis is one of the most common urinary tract diseases. After the first episode of urinary calculus, the risk of recurrence is nearly 40% to 50% at 5 years. Nephrolithiasis is a systemic disease that is associated with some metabolic disorders. This study aimed to provide a picture of the frequency of metabolic abnormalities in patients with nephrolithiasis from west part of Iran. MATERIALS AND METHODS: Patients with recurrent urinary tract calculi referred to the Nephrology-Urology Clinics in Khorramabad city were recruited...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421299/impact-of-statin-intake-on-kidney-stone-formation
#11
Andrew J Cohen, Melanie A Adamsky, Charles U Nottingham, Jaclyn Pruitt, Brittany Lapin, Chi H Wang, Sangtae Park
OBJECTIVES: To determine whether statin intake affects nephrolithiasis risk, and whether higher lipid levels correlate with stone risk. Dyslipidemia is a known independent risk factor for urolithiasis, and emerging evidence suggests common biological pathways. Previous work has suggested that statins protect against new stone formation, but these findings have not been verified by other investigators. METHODS: We queried our Institution's Electronic Data Warehouse for all patients who were newly diagnosed with hyperlipidemia between 2009 and 2011, and had never taken a statin drug...
February 5, 2018: Urology
https://www.readbyqxmd.com/read/29406065/urologic-emergencies
#12
REVIEW
Adarsh S Manjunath, Matthias D Hofer
Urologic emergencies can involve the kidneys, ureters, bladder, urethra, penis, scrotum, or testicles. History and physical examination are essential to diagnosis, whereas imaging is increasingly used to confirm diagnoses. Acute urinary retention should be relieved with Foley placement. Penile emergencies include paraphimosis, which can be treated by foreskin reduction, whereas penile fracture and priapism require urologic intervention. Fournier gangrene and testicular torsion are scrotal emergencies requiring emergent surgery...
March 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29400579/occult-urolithiasis-in-asymptomatic-primary-hyperparathyroidism
#13
Yu-Kwang Donovan Tay, Minghao Liu, Leonardo Bandeira, Mariana Bucovsky, James A Lee, Shonni J Silverberg, Marcella D Walker
OBJECTIVE: Recent international guidelines suggest renal imaging to detect occult urolithiasis in all patients with asymptomatic primary hyperparathyroidism (PHPT), but data regarding their prevalence and associated risk factors are limited. We evaluated the prevalence and risk factors for occult urolithiasis. METHODS: Cross-sectional analysis of 96 asymptomatic PHPT patients from a university hospital in the United States with and without occult nephrolithiasis...
February 5, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29394966/factors-affecting-dermatological-manifestations-in-patients-with-end-stage-renal-disease
#14
Muhammad Anees, Ghazala Butt, Shaista Gull, Asif Nazeer, Ijaz Hussain, Muhammad Ibrahim
OBJECTIVE: To determine skin changes in patients of End Stage Renal Disease (ESRD) on maintenance hemodialysis (MHD) and factors affecting these changes. STUDY DESIGN: Cross-sectional observational study. PLACE AND DURATION OF STUDY: Nephrology Department, Mayo Hospital, Lahore in collaboration with Dermatology Department, King Edward Medical University, Lahore, from October 2015 to January 2016. METHODOLOGY: Two hundred patients who were undergoing MHD for more than three months were included in the study...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29393127/uric-acid-renal-lithiasis-new-concepts
#15
Fabiola Pazos Pérez
BACKGROUND: Uric acid (UA) stones are responsible for 5-10% of the formation of all kidney stones. Recently, an association between UA stones and insulin resistance, diabetes mellitus, and obesity has been demonstrated and so the incidence has increased. The development of UA stones is dependent on several risk factors, including genetic predisposition, geographical location, dietary indiscretion, and various metabolic characteristics. SUMMARY: UA nephrolithiasis can arise from diverse etiologies, all with distinct underlying defects converging to one or more of 3 defects of hyperuricosuria, acidic urine pH, and low urinary volume...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29386759/tubeless-pediatric-percutaneous-nephrolithotomy-assessment-of-feasibility-and-safety
#16
Ramaiah Keshavamurthy, Sumit Kumar, Vilvapathy Senguttuvan Karthikeyan, Ashwin Mallya, Girish Gurubasappa Nelivigi
Introduction: Tubeless pediatric percutaneous nephrolithotomy (TL-PCNL) is evolving and adult criteria are being safely applied to children. We examine the feasibility, safety, and outcomes of pediatric TL. Materials and Methods: A retrospective review of pediatric (≤18 years) PCNL patients at our institute was done. Patients eligible for TL but underwent tube (T) PCNL due to surgeon choice or protocol were compared with TL. Only children with 100% stone clearance were included, and those receiving nephrostomy for intraoperative complications were excluded from the study...
January 2018: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/29385814/addition-of-sodium-bicarbonate-to-irrigation-solution-may-assist-in-dissolution-of-uric-acid-fragments-during-ureteroscopy
#17
Jessica E Paonessa, James Caldwell Williams, James E Lingeman
INTRODUCTION: We hypothesized that adding sodium bicarbonate (bicarb) to normal saline (NS) irrigation during ureteroscopy (URS) in patients with uric acid (UA) nephrolithiasis may assist in dissolving small stone fragments produced during laser lithotripsy. In vitro testing was performed to determine if dissolution of UA fragments could be accomplished within one hour. MATERIALS AND METHODS: 100% UA renal calculi were fragmented, filtered, and separated by size...
January 31, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29380131/increasing-the-size-of-ureteral-access-sheath-during-retrograde-intrarenal-surgery-improves-surgical-efficiency-without-increasing-complications
#18
Chad R Tracy, George M Ghareeb, Charles J Paul, Nathan A Brooks
PURPOSE: To directly compare intraoperative and post-operative outcomes and complications between three groups undergoing ureteroscopy: no ureteral access sheath, 12/14 Fr and larger 14/16 Fr ureteral access sheaths (UAS). METHODS: We retrospectively reviewed demographic, pre-operative, intraoperative, and post-operative data of 257 patients who underwent ureteroscopy for nephrolithiasis by a single surgeon from January 2013 through July 2015. Patients were separated into three groups: no UAS, a 12/14 Fr UAS, or 14/16 Fr UAS...
January 27, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29376607/-idiopathic-hypercalciuria-diagnosis-and-treatment
#19
Yu V Olefir, A N Yavorskii, D V Butnaru, O V Shatalova, V S Gorbatenko, A S Gerasimenko
Most patients with idiopathic hypercalciuria and calcium nephrolithiasis have a family history of the disease. Idiopathic hypercalciuria is a metabolic abnormality with various causes and developmental pathways. The systematic review describes specific mutations associated with idiopathic hypercalciuria and nephrolithiasis. Detection of these mutations may provide a better understanding of the pathogenesis of this heterogeneous disease and personalize patient management depending on the detected polymorphisms...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29370644/re-multiple-sclerosis-and-nephrolithiasis-a-matched-case-comparative-study
#20
Dean G Assimos
No abstract text is available yet for this article.
August 2017: Journal of Urology
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