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https://www.readbyqxmd.com/read/28209491/the-preterm-cervix-reveals-a-transcriptomic-signature-in-the-presence-of-premature-pre-labor-rupture-of-membranes
#1
Sofia Makieva, Aurelija Dubicke, Sara F Rinaldi, Emma Fransson, Gunvor Ekman-Ordeberg, Jane E Norman
BACKGROUND: Premature Pre-labor Rupture of Fetal Membranes (PPROM) accounts for 30% of all premature births and is associated with detrimental long-term infant outcomes. Premature cervical remodeling, facilitated by matrix metalloproteinases (MMPs), may trigger rupture at the zone of the fetal membranes overlying the cervix. The similarities and differences underlying cervical remodeling in PPROM and spontaneous preterm labor with intact membranes (PTL) are unexplored. OBJECTIVES: We aimed a) to perform the first transcriptomic assessment of the preterm human cervix to identify differences between PPROM and PTL and b) to compare the enzymatic activities of MMP-2 and 9 between PPROM and PTL...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28202378/neonatology-oxidative-status-in-preterm-infants-with-premature-preterm-rupture-of-membranes-and-fetal-inflammatuar-response-syndrome
#2
Elif Özalkaya, Güner Karatekin, Sevilay Topçuoğlu, Hande Özgün Karatepe, Taner Hafızoğlu, Pervin Baran, Fahri Ovalı
BACKGROUND: The aim of this study, to determine an index of oxidative stress index in preterm infants less than 34 weeks gestational age with premature preterm rupture of membrane (PPROM) and fetal inflammatory response syndrome (FIRS). METHODS: This study was designed as a prospective study. Fifty-one premature infants less than 35 weeks of gestational age were included in the study. The umbilical cord blood concentrations of IL-6, TAC (total antioxidant capacity) and PON-1 (paraoxonase-1) levels and TOS (total oxidative stress) were studied...
January 17, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28186639/a-retrospective-cohort-study-of-hospital-versus-home-care-for-pregnant-women-with-preterm-prelabor-rupture-of-membranes
#3
Lynne Palmer, Kirsten Grabowska, Jason Burrows, Hilary Rowe, Erin Billing, Amy Metcalfe
OBJECTIVE: To compare maternal and neonatal outcomes between in-hospital management and prepartum care at home (PCAH) among women with preterm prelabor rupture of membranes (PPROM) before 34 weeks of pregnancy. METHODS: In a retrospective study, data were analyzed from women who experienced PPROM between 23 and 34 weeks of pregnancy, and received care from two hospitals in British Columbia, Canada, between April 2007 and March 2012. Women were included if they had been stable in hospital for at least 72 hours and met eligibility criteria for PCAH...
February 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28182768/clinical-validation-of-a-model-predicting-the-risk-of-preterm-delivery
#4
Yohann Dabi, Sophie Nedellec, Claire Bonneau, Blandine Trouchard, Roman Rouzier, Alexandra Benachi
OBJECTIVES: To validate a model predicting the risk of threatened preterm delivery and to establish the optimal threshold for this risk scoring system. MATERIALS AND METHODS: Two cohorts were studied: one of singleton pregnancies without preterm premature rupture of membranes (PPROM) and no cervical cerclage (cohort 1) and one of twin pregnancies without PPROM and no cervical cerclage (cohort 2). Patients were included from January 1st 2013 until December 31st 2013 by the Regional Perinatal Network of Ile de France with patients transferred because of threatened preterm delivery at 22 to 32 weeks of gestation...
2017: PloS One
https://www.readbyqxmd.com/read/28168638/the-relationship-between-the-latency-period-infection-markers-and-oxidant-and-antioxidant-states-in-women-with-preterm-premature-rupture-of-membranes
#5
N Ilhan, B K Aygun, H Gungor
BACKGROUND: A major cause of perinatal morbidity and mortality has been reported to be preterm premature rupture of membranes (PPROM). Our objective was to evaluate oxidant-antioxidant balance, infection parameters, time interval between rupture of membranes and delivery (latency period), and the relationship among all these parameters. METHODS: Seventy-five cases with PPROM between 24 and 34 gestational weeks were included in the study. A control group of 41 women who gave birth at term were considered as the control group...
February 6, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28160689/predictive-value-of-vaginal-il-6-and-tnf%C3%AE-bedside-tests-repeated-until-delivery-for-the-prediction-of-maternal-fetal-infection-in-cases-of-premature-rupture-of-membranes
#6
Gilles Kayem, Frederic Batteux, Noémie Girard, Thomas Schmitz, Marion Willaime, Francoise Maillard, Pierre Henri Jarreau, Francois Goffinet
OBJECTIVE: Examine the predictive value for maternal-fetal infection of routine bedside tests detecting the proinflammatory cytokines, TNFα and IL-6, in the vaginal secretions of women with premature rupture of the membranes (PROM). STUDY DESIGN: This prospective two-center cohort study included all women hospitalized for PROM over a 2-year period. A bedside test assessed IL-6 and TNFα in vaginal secretions. Both centers routinely tested CRP and leukocytes, assaying both in maternal serum, and analyzed vaginal bacterial flora; all samples were repeated twice weekly until delivery...
January 12, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28152632/cervical-fluid-calreticulin-and-cathepsin-g-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-membranes
#7
Ctirad Andrys, Ivana Musilova, Marcela Drahosova, Ondrej Soucek, Lenka Pliskova, Bo Jacobsson, Nanbert Zhong, Marian Kacerovsky
OBJECTIVE: The study aimed to determine the cervical calreticulin and cathepsin-G concentrations in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) with respect to the presence of microbial invasion of the amniotic cavity (MIAC) and intra-amniotic inflammation (IAI). METHODS: Eighty women with singleton pregnancies complicated by PPROM were included in this study. Cervical and amniotic fluids were obtained at the time of admission, and concentrations of calreticulin and cathepsin-G in cervical fluid were determined using ELISA...
February 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28130929/use-of-antenatal-corticosteroids-in-special-circumstances-a-comprehensive-review
#8
Everett F Magann, Kjell Haram, Songthip Ounpraseuth, Jan Helge Mortensen, Horace J Spencer, John C Morrison
OBJECTIVE: To determine in pregnancies complicated by preterm premature rupture of membranes (PPROM), hypertension, intrauterine growth restriction, multi-fetal gestations and pregnancies 23- 26 weeks≥ 34 weeks gestation whether antenatal corticosteroids benefit the fetus. DATA SOURCES: Literature review using PubMed, Web of Science, Clinical trials. gov, Cochrane Database of Systematic Reviews (1990 - 2015). METHODS OF STUDY SELECTION: Search terms linked special circumstances with corticosteroids...
January 28, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28099729/maternal-c-reactive-protein-and-oxidative-stress-markers-as-predictors-of-delivery-latency-in-patients-experiencing-preterm-premature-rupture-of-membranes
#9
Hyun Kyung Ryu, Jong Ho Moon, Hyun Ji Heo, Jong Woon Kim, Yoon Ha Kim
OBJECTIVE: To evaluate the usefulness of maternal serum c-reactive protein (CRP), lipid peroxide, and oxygen radical absorbance capacity (ORAC), to predict the interval between membrane rupture and delivery in patients with preterm premature rupture of membranes (PPROM). METHODS: The present prospective study included patients with singleton pregnancies experiencing PPROM at earlier than 34 weeks of pregnancy who underwent spontaneous vaginal delivery between August 1, 2010 and July 31, 2013 at Chonnam National University Hospital, Republic of Korea...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28079822/successfully-treated-congenital-cystic-adenomatoid-malformation-by-open-fetal-surgery-a-care-compliant-case-report-of-a-5-year-follow-up-and-review-of-the-literature
#10
REVIEW
Dazhi Fan, Shuzhen Wu, Rui Wang, Yi Huang, Yao Fu, Wen Ai, Meng Zeng, Xiaoling Guo, Zhengping Liu
BACKGROUND: Congenital cystic adenomatoid malformation (CCAM) is a rare hamartomatous cystic lesion. Open fetal surgery currently provides a potential therapeutic option for management of a fetus with CCAM diagnosis. CASE SUMMARY: A 22-year-old G2P0 woman presented at (Equation is included in full-text article.)weeks' gestation for evaluation of a fetus with a left lung lesion and diagnosed as CCAM at (Equation is included in full-text article.)weeks' gestation...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28068953/pregnant-human-peripheral-leukocyte-migration-during-several-late-pregnancy-clinical-conditions-a-cross-sectional-observational-study
#11
Jun Takeda, Xin Fang, David M Olson
BACKGROUND: Parturition at term and preterm is characterized by sterile inflammatory processes occurring in the absence of infection whereby peripheral leukocytes infiltrate gestational tissues in response to chemotactic signals. In response to a homing signal, recruited leukocytes undergo diapedesis and extravasate through capillaries, migrating into stromal tissue. There they interact with resident immune and stromal cells to produce a mixture of matrix metalloproteinases, prostaglandins and cytokines including interleukin-1β (IL-1β) and IL-6 that in turn transform the uterus from pregnancy to parturition...
January 10, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28029463/-tocolysis-for-preterm-labor-without-premature-preterm-rupture-of-membranes
#12
M Doret, G Kayem
OBJECTIVES: To propose guidelines for clinical practice for tocolysis in preterm labor without premature preterm rupture of the membranes (PPROM). MATERIALS AND METHODS: Bibliographic searches were performed in the Medline and Cochrane databases and gynecologist and obstetricians' international society guidelines. It is important to note that most studies included women in preterm labour with and without PPROM. RESULTS: Compared with placebo, tocolytics are not associated with a reduction in neonatal mortality or morbidity (LE2)...
October 28, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/28029224/preterm-prelabour-rupture-of-membranes-a-retrospective-cohort-study-of-association-with-adverse-outcome-in-subsequent-pregnancy
#13
I M Aris, S Logan, C Lim, M Choolani, A Biswas, S Bhattacharya
OBJECTIVE: To assess the association of first pregnancy preterm prelabour rupture of membranes (PPROM) with adverse maternal and perinatal outcomes in the next pregnancy. DESIGN: Retrospective cohort study. SETTING: Grampian, Scotland, UK. POPULATION: Women with first deliveries recorded in the Aberdeen Maternity Neonatal Databank, 1986-2005. METHODS: Women identified from the AMND database (n = 37 776) were classified into exposed (PPROM in first pregnancy; n = 1979) and unexposed (no PPROM in first pregnancy; n = 35 797) cohorts...
December 28, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28002986/evaluating-the-effects-of-copper-supplement-during-pregnancy-on-premature-rupture-of-membranes-and-pregnancy-outcome
#14
Maryam Kashanian, Hasti Hadizadeh, Masoomeh Faghankhani, Mitra Nazemi, Narges Sheikhansari
OBJECTIVE: To evaluate the effects of copper (Cu) supplementation during pregnancy on the rupture of membranes and pregnancy outcomes. METHODS: Study was conducted as a triple-blind randomized clinical trial. In one group, Cu in a dose of 1000 mg per day, and in the other group, placebo was prescribed orally from 16th week of pregnancy. RESULTS: The women of the two groups did not have significant difference according to age, gestational age at recruitment, BMI, and socioeconomic conditions...
January 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27994922/diagnostic-and-prognostic-value-of-presepsin-for-subclinical-chorioamnionitis-in-pregnancies-between-23-28-week-with-preterm-premature-rupture-of-the-membranes
#15
Erbil Çakar, Şule Eren Çakar, Habibe Ayvacı Taşan, Deniz Karçaaltıncaba, Mehmet Baki Şentürk, Nermin Koç, Ramazan Uluhan
BACKGROUND: Presepsin is an inflammatory marker released from monocytes and macrophages as an acute reaction to microbial infection. We hypothesized that it may be useful in pregnancies with preterm premature rupture of the membranes (PPROM) for early diagnosis of subclinical chorioamnionitis. AIMS: To determine whether the plasma presepsin level has any diagnostic or prognostic value for subclinical chorioamnionitis in pregnancies complicated with PPROM. STUDY DESIGN: Prospective cohort study...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27992249/the-role-of-epithelial-to-mesenchymal-transition-in-human-amniotic-membrane-rupture
#16
Carla Janzen, Suvajit Sen, Margarida Y Y Lei, Marina Gagliardi de Assumpcao, John Challis, Gautam Chaudhuri
CONTEXT: Biochemical weakening of the amnion is a major factor preceding preterm premature rupture of membranes (PPROM), leading to preterm birth. Activation of matrix metalloproteinases (MMPs) is known to play a key role in collagen degradation of the amnion, yet epithelial to mesenchymal transition (EMT) that is also induced by MMP activation, has not been investigated as a mechanism for amnion weakening. OBJECTIVE: To measure amniotic EMT associated with vaginal delivery (VD) as compared to non-labored cesarean sections (CS), and assess changes in amniotic mechanical strength with pharmacologic inhibitors and inducers of EMT, thus testing the hypothesis that EMT is a key biochemical event that promotes amniotic rupture...
December 19, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27938341/fetal-membrane-imaging-and-the-prediction-of-preterm-birth-a-systematic-review-current-issues-and-future-directions
#17
Vanessa Nunes, Jennifer Cross, John E Speich, Danielle R Morgan, Jerome F Strauss, Ronald M Ramus
BACKGROUND: Preterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients. Our goal was to identify how imaging methods can be utilized for examining the risks for PPROM in asymptomatic patients. METHODS: This paper is a systematic review of the literature on fetal membrane thickness and its use for the prediction of PPROM. Four key studies are identified and reviewed; two in vitro studies and two in vivo ultrasound studies each using differing methodologies...
December 9, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27935855/estimation-of-fetal-weight-by-ultrasonography-after-preterm-premature-rupture-of-membranes-comparison-of-different-formulas
#18
Sertac Esin, Mutlu Hayran, Yusuf Aytac Tohma, Mahmut Guden, Ismail Alay, Deniz Esinler, Serdar Yalvac, Omer Kandemir
OBJECTIVE: To compare different ultrasonographic fetal weight estimation formulas in predicting the fetal birth weight of preterm premature rupture of membrane (PPROM) fetuses. METHODS: Based on the ultrasonographic measurements, the estimated fetal weight (EFW) was calculated according to the published formulas. The comparisons used estimated birth weight (EBW) and observed birth weight (OBW) to calculate the mean absolute percentage error [(EBW-OBW)/OBW×100], mean percentage error [(EBW-OBW)/OBW×100)] and their 95% confidence intervals...
February 1, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27861554/high-diversity-and-variability-in-the-vaginal-microbiome-in-women-following-preterm-premature-rupture-of-membranes-pprom-a-prospective-cohort-study
#19
Teenus Paramel Jayaprakash, Emily C Wagner, Julie van Schalkwyk, Arianne Y K Albert, Janet E Hill, Deborah M Money
OBJECTIVE: To characterize the vaginal microbiota of women following preterm premature rupture of membranes (PPROM), and determine if microbiome composition predicts latency duration and perinatal outcomes. DESIGN: A prospective cohort study. SETTING: Canada. POPULATION: Women with PPROM between 24+0 and 33+6 weeks gestational age (GA). METHODS: Microbiome profiles, based on pyrosequencing of the cpn60 universal target, were generated from vaginal samples at time of presentation with PPROM, weekly thereafter, and at delivery...
2016: PloS One
https://www.readbyqxmd.com/read/27831903/calciprotein-particles-as-potential-etiologic-agents-of-idiopathic-preterm-birth
#20
Lydia L Shook, Catalin S Buhimschi, Antonette T Dulay, Megan E McCarthy, John T Hardy, Christina M Duzyj Buniak, Guomao Zhao, Irina A Buhimschi
Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality and is often preceded by preterm premature rupture of the membranes (PPROM) without an identifiable cause. Pathological calcification, the deposition of hydroxyapatite (HA) in nonskeletal tissues, has been implicated in degenerative diseases including atherosclerosis and aneurism rupture. Among pathogenic mechanisms, the aberrant aggregation of HA into calciprotein particles (CPPs) and the HA-induced differentiation of mesenchymal cells into osteoblasts (ectopic osteogenesis) have been implicated...
November 9, 2016: Science Translational Medicine
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