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https://www.readbyqxmd.com/read/28079822/successfully-treated-congenital-cystic-adenomatoid-malformation-by-open-fetal-surgery-a-care-compliant-case-report-of-a-5-year-follow-up-and-review-of-the-literature
#1
Dazhi Fan, Shuzhen Wu, Rui Wang, Yi Huang, Yao Fu, Wen Ai, Meng Zeng, Xiaoling Guo, Zhengping Liu
BACKGROUND: Congenital cystic adenomatoid malformation (CCAM) is a rare hamartomatous cystic lesion. Open fetal surgery currently provides a potential therapeutic option for management of a fetus with CCAM diagnosis. CASE SUMMARY: A 22-year-old G2P0 woman presented at (Equation is included in full-text article.)weeks' gestation for evaluation of a fetus with a left lung lesion and diagnosed as CCAM at (Equation is included in full-text article.)weeks' gestation...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28068953/pregnant-human-peripheral-leukocyte-migration-during-several-late-pregnancy-clinical-conditions-a-cross-sectional-observational-study
#2
Jun Takeda, Xin Fang, David M Olson
BACKGROUND: Parturition at term and preterm is characterized by sterile inflammatory processes occurring in the absence of infection whereby peripheral leukocytes infiltrate gestational tissues in response to chemotactic signals. In response to a homing signal, recruited leukocytes undergo diapedesis and extravasate through capillaries, migrating into stromal tissue. There they interact with resident immune and stromal cells to produce a mixture of matrix metalloproteinases, prostaglandins and cytokines including interleukin-1β (IL-1β) and IL-6 that in turn transform the uterus from pregnancy to parturition...
January 10, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28029463/-tocolysis-for-preterm-labor-without-premature-preterm-rupture-of-membranes
#3
M Doret, G Kayem
OBJECTIVES: To propose guidelines for clinical practice for tocolysis in preterm labor without premature preterm rupture of the membranes (PPROM). MATERIALS AND METHODS: Bibliographic searches were performed in the Medline and Cochrane databases and gynecologist and obstetricians' international society guidelines. It is important to note that most studies included women in preterm labour with and without PPROM. RESULTS: Compared with placebo, tocolytics are not associated with a reduction in neonatal mortality or morbidity (LE2)...
October 28, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/28029224/preterm-prelabour-rupture-of-membranes-a-retrospective-cohort-study-of-association-with-adverse-outcome-in-subsequent-pregnancy
#4
I M Aris, S Logan, C Lim, M Choolani, A Biswas, S Bhattacharya
OBJECTIVE: To assess the association of first pregnancy preterm prelabour rupture of membranes (PPROM) with adverse maternal and perinatal outcomes in the next pregnancy. DESIGN: Retrospective cohort study. SETTING: Grampian, Scotland, UK. POPULATION: Women with first deliveries recorded in the Aberdeen Maternity Neonatal Databank, 1986-2005. METHODS: Women identified from the AMND database (n = 37 776) were classified into exposed (PPROM in first pregnancy; n = 1979) and unexposed (no PPROM in first pregnancy; n = 35 797) cohorts...
December 28, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28002986/evaluating-the-effects-of-copper-supplement-during-pregnancy-on-premature-rupture-of-membranes-and-pregnancy-outcome
#5
Maryam Kashanian, Hasti Hadizadeh, Masoomeh Faghankhani, Mitra Nazemi, Narges Sheikhansari
OBJECTIVE: To evaluate the effects of copper supplementation during pregnancy on the rupture of membranes and pregnancy outcomes. METHOD: Study was conducted as a triple blind randomized clinical trial. In one group copper in a dose of 1000 milligram per day and in the other group, placebo was prescribed orally from 16th week of pregnancy. RESULTS: The women of the 2 groups did not have significant difference according to age, gestational age at recruitment, BMI, and socioeconomic conditions...
December 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27994922/diagnostic-and-prognostic-value-of-presepsin-for-subclinical-chorioamnionitis-in-pregnancies-between-23-28-week-with-preterm-premature-rupture-of-the-membranes
#6
Erbil Çakar, Şule Eren Çakar, Habibe Ayvacı Taşan, Deniz Karçaaltıncaba, Mehmet Baki Şentürk, Nermin Koç, Ramazan Uluhan
BACKGROUND: Presepsin is an inflammatory marker released from monocytes and macrophages as an acute reaction to microbial infection. We hypothesized that it may be useful in pregnancies with preterm premature rupture of the membranes (PPROM) for early diagnosis of subclinical chorioamnionitis. AIMS: To determine whether the plasma presepsin level has any diagnostic or prognostic value for subclinical chorioamnionitis in pregnancies complicated with PPROM. STUDY DESIGN: Prospective cohort study...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27992249/the-role-of-epithelial-to-mesenchymal-transition-in-human-amniotic-membrane-rupture
#7
Carla Janzen, Suvajit Sen, Margarida Y Y Lei, Marina Gagliardi de Assumpcao, John Challis, Gautam Chaudhuri
CONTEXT: Biochemical weakening of the amnion is a major factor preceding preterm premature rupture of membranes (PPROM), leading to preterm birth. Activation of matrix metalloproteinases (MMPs) is known to play a key role in collagen degradation of the amnion, yet epithelial to mesenchymal transition (EMT) that is also induced by MMP activation, has not been investigated as a mechanism for amnion weakening. OBJECTIVE: To measure amniotic EMT associated with vaginal delivery (VD) as compared to non-labored cesarean sections (CS), and assess changes in amniotic mechanical strength with pharmacologic inhibitors and inducers of EMT, thus testing the hypothesis that EMT is a key biochemical event that promotes amniotic rupture...
December 19, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27938341/fetal-membrane-imaging-and-the-prediction-of-preterm-birth-a-systematic-review-current-issues-and-future-directions
#8
Vanessa Nunes, Jennifer Cross, John E Speich, Danielle R Morgan, Jerome F Strauss, Ronald M Ramus
BACKGROUND: Preterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients. Our goal was to identify how imaging methods can be utilized for examining the risks for PPROM in asymptomatic patients. METHODS: This paper is a systematic review of the literature on fetal membrane thickness and its use for the prediction of PPROM. Four key studies are identified and reviewed; two in vitro studies and two in vivo ultrasound studies each using differing methodologies...
December 9, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27935855/estimation-of-fetal-weight-by-ultrasonography-after-preterm-premature-rupture-of-membranes-comparison-of-different-formulas
#9
Sertac Esin, Mutlu Hayran, Yusuf Aytac Tohma, Mahmut Guden, Ismail Alay, Deniz Esinler, Serdar Yalvac, Omer Kandemir
OBJECTIVE: To compare different ultrasonographic fetal weight estimation formulas in predicting the fetal birth weight of preterm premature rupture of membrane (PPROM) fetuses. METHODS: Based on the ultrasonographic measurements, the estimated fetal weight (EFW) was calculated according to the published formulas. The comparisons used estimated birth weight (EBW) and observed birth weight (OBW) to calculate the mean absolute percentage error [(EBW-OBW)/OBW×100], mean percentage error [(EBW-OBW)/OBW×100)] and their 95% confidence intervals...
December 9, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27861554/high-diversity-and-variability-in-the-vaginal-microbiome-in-women-following-preterm-premature-rupture-of-membranes-pprom-a-prospective-cohort-study
#10
Teenus Paramel Jayaprakash, Emily C Wagner, Julie van Schalkwyk, Arianne Y K Albert, Janet E Hill, Deborah M Money
OBJECTIVE: To characterize the vaginal microbiota of women following preterm premature rupture of membranes (PPROM), and determine if microbiome composition predicts latency duration and perinatal outcomes. DESIGN: A prospective cohort study. SETTING: Canada. POPULATION: Women with PPROM between 24+0 and 33+6 weeks gestational age (GA). METHODS: Microbiome profiles, based on pyrosequencing of the cpn60 universal target, were generated from vaginal samples at time of presentation with PPROM, weekly thereafter, and at delivery...
2016: PloS One
https://www.readbyqxmd.com/read/27831903/calciprotein-particles-as-potential-etiologic-agents-of-idiopathic-preterm-birth
#11
Lydia L Shook, Catalin S Buhimschi, Antonette T Dulay, Megan E McCarthy, John T Hardy, Christina M Duzyj Buniak, Guomao Zhao, Irina A Buhimschi
Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality and is often preceded by preterm premature rupture of the membranes (PPROM) without an identifiable cause. Pathological calcification, the deposition of hydroxyapatite (HA) in nonskeletal tissues, has been implicated in degenerative diseases including atherosclerosis and aneurism rupture. Among pathogenic mechanisms, the aberrant aggregation of HA into calciprotein particles (CPPs) and the HA-induced differentiation of mesenchymal cells into osteoblasts (ectopic osteogenesis) have been implicated...
November 9, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27825282/relationship-between-maternal-c-reactive-protein-level-and-neonatal-outcome-in-patients-with-preterm-premature-rupture-of-membranes-treated-with-ampicillin-and-azithromycin
#12
Mehmet Serdar Kutuk, Osman Bastug, Ahmet Ozdemir, Mehmet Adnan Ozturk, Mahmut Tuncay Ozgun, Mustafa Basbug, Tamer Gunes, Selim Kurtoglu
This historical cohort study aimed to assess the relationship between antenatal maternal C-reactive protein (CRP) level and neonatal outcome preterm premature rupture of membranes (PPROM). We reviewed the records of 70 singleton pregnancies with PPROM between 24 and 34 weeks. Maternal CRP levels of neonates with respiratory distress syndrome, neonatal sepsis, grade 3-4 intraventricular haemorrhage and stage 2-3 necrotizing enterocolitis, perinatal mortality were compared with those without these complications...
August 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27821983/using-sonographically-estimated-myometrial-thickness-in-prediction-of-latency-interval-in-cases-of-preterm-premature-rupture-of-membranes-pprom
#13
Richa Gupta, Ajit Nagarsenkar
OBJECTIVES: To study myometrial thickness (MT) sonographically as a predictor of latency interval in women with preterm premature rupture of membranes (PPROM). STUDY DESIGN: The data were collected in a prospective manner from the antenatal patients between November 2011 and June 2013 during the follow-up of patients in the Department of Obstetrics and Gynecology, Goa Medical College. 100 patients with the periods of gestation of 28-36 weeks were studied, out of which 50 were PPROM cases and 50 were controls, both not in labor...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27811444/morbidities-concordance-and-predictors-of-preterm-premature-rupture-of-membranes-among-pregnant-women-at-the-university-of-nigeria-teaching-hospital-unth-enugu-nigeria
#14
T C Okeke, J O Enwereji, C O Adiri, C I Onwuka, E S Iferikigwe
BACKGROUND: Preterm premature rupture of membranes (PPROM) is a challenging complication of pregnancies and an important cause of perinatal morbidity and mortality. Management of morbidities associated with PPROM is fraught with controversy. However, women should be informed of these complications. OBJECTIVE: This article aimed to review the morbidities, concordance, and predictors of PPROM over a 10-year period. METHODS: This was a retrospective review of morbidities, concordance, and predictors of PPROM among pregnant women at the University of Nigeria Teaching Hospital, Enugu, Nigeria between January 1, 1999, and December 31, 2008...
November 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27806672/amniotic-fluid-clusterin-in-pregnancies-complicated-by-the-preterm-prelabor-rupture-of-membranes
#15
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Ondrej Soucek, Lenka Pliskova, Martin Stepan, Tomas Bestvina, Jan Maly, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: The aim of this study was to evaluate clusterin concentrations in amniotic fluid in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) with respect to the presence of the microbial invasion of the amniotic cavity (MIAC), intra-amniotic inflammation (IAI), and microbial-associated IAI. METHODS: One hundred thirty-six women with singleton pregnancies complicated by preterm prelabor rupture of membranes were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis...
November 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27794570/limiting-the-exposure-of-select-fetuses-to-intrauterine-infection-inflammation-improves-short-term-neonatal-outcomes-in-preterm-premature-rupture-of-membranes
#16
Karen L Archabald, Irina A Buhimschi, Mert O Bahtiyar, Antonette T Dulay, Sonya S Abdel-Razeq, Christian M Pettker, Heather S Lipkind, John T Hardy, Megan E McCarthy, Guomao Zhao, Vineet Bhandari, Catalin S Buhimschi
BACKGROUND: To improve neonatal outcomes in pregnancies at heightened risk for early-onset neonatal sepsis (EONS), there is a need to identify fetuses that benefit from expectant management as opposed to early delivery. Detectable haptoglobin and haptoglobin-related protein (Hp&HpRP switch-on status) in cord blood has been proposed as a biomarker of antenatal exposure to intra-amniotic infection and/or inflammation (IAI), an important determinant of EONS. SUBJECTS AND METHODS: We analyzed 185 singleton newborns delivered secondary to preterm premature rupture of membranes (PPROM)...
October 29, 2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27780541/atf3-is-a-negative-regulator-of-inflammation-in-human-fetal-membranes
#17
Ratana Lim, Gillian Barker, Stella Liong, Caitlyn Nguyen-Ngo, Stephen Tong, Tu'uhevaha Kaitu'u-Lino, Martha Lappas
INTRODUCTION: Infection and inflammation stimulate pro-inflammatory cytokines, prostaglandins and matrix metalloproteinase (MMP)-9, which play a central role in myometrial contractions and rupture of fetal membranes. In human and mouse immune cells, activating transcription factor 3 (ATF3) is a negative regulator of inflammation. No studies have examined the role of ATF3 in human labour. METHODS: Primary amnion cells were used to determine the effect of interleukin (IL)-1β and the bacterial product fibroblast-stimulating lipopeptide (fsl-1) on ATF3 expression, and the effect of ATF3 siRNA on pro-labour mediators...
November 2016: Placenta
https://www.readbyqxmd.com/read/27780154/maternal-and-neonatal-outcomes-following-expectant-management-of-preterm-prelabour-rupture-of-membranes-before-viability
#18
Winnie Huiyan Sim, Edward Araujo Júnior, Fabricio Da Silva Costa, Penelope Marie Sheehan
AIM: To assess the contemporary maternal and neonatal outcomes following expectant management of preterm premature rupture of membranes (PPROM) prior to 24 weeks' gestation and to identify prognostic indicators of this morbid presentation. METHODS: We performed a systematic review in the Pubmed and EMBASE databases to identify the primary (perinatal mortality, severe neonatal morbidity and serious maternal morbidity) and secondary (neonatal survival and morbidity) outcomes following expectant management of previable PPROM...
January 1, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27769742/all-trans-retinoic-acid-promotes-wound-healing-of-primary-amniocytes-through-the-induction-of-loxl4-a-member-of-the-lysyl-oxidase-family
#19
Marion Rouzaire, Aurélie Comptour, Corinne Belville, Damien Bouvier, Gaël Clairefond, Flora Ponelle, Vincent Sapin, Denis Gallot, Loïc Blanchon
Thirty percent of preterm births directly result from preterm premature rupture of fetal membranes (PPROM). Clinical management currently proposes using a collagen plug to mechanically stop loss of amniotic fluid. Vitamin A and its active metabolite (retinoic acid) have well-known pro-healing properties and could thus make good candidates as a proposable adjuvant to this mechanical approach. Here we investigate the molecular mechanisms involved in the pro-healing properties of all-trans retinoic acid (atRA) in fetal membranes via an approach using an in vitro primary amniocyte wound model and transcriptomics...
December 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27744438/vaginal-probiotic-administration-in-the-management-of-preterm-premature-rupture-of-membranes
#20
George J Daskalakis, Alexis K Karambelas
OBJECTIVE: To examine the influence of vaginal probiotic administration as an adjunct to standard antibiotic treatment on perinatal outcome in women with preterm premature rupture of membranes (PPROM). MATERIALS AND METHODS: This was a prospective randomized trial of cases with PPROM (24-34 weeks) that were admitted to our department between 2011 and 2015. Forty-nine cases received vaginal probiotics for 10 days in combination with antibiotic prophylaxis and were compared to 57 others that received only antibiotics for the same time period...
October 15, 2016: Fetal Diagnosis and Therapy
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