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aminoguanidine

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https://www.readbyqxmd.com/read/28386146/histological-and-immunohistochemical-basis-of-the-effect-of-aminoguanidine-on-renal-changes-associated-with-hemorrhagic-shock-in-a-rat-model
#1
Abdulmajeed Al Drees, Mahmoud Salah Khalil, Mona Soliman
Acute kidney failure is the main cause of death among patients with severe trauma due to massive blood loss and hemorrhagic shock (HS). Renal cell injury is caused by tissue ischemia. Renal ischemia initiates a complex and interconnected chain of events resulting in cell injury and renal cell necrosis. Nitric oxide plays a crucial role in renal function and can be inhibited by aminoguanidine (AG). We studied whether AG can ameliorate pathological renal changes associated with HS syndrome in a rat model and explored the AG protection mechanism...
February 28, 2017: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/28367927/beneficial-effects-of-lemon-balm-leaf-extract-on-in-vitro-glycation-of-proteins-arterial-stiffness-and-skin-elasticity-in-healthy-adults
#2
Shintaro Yui, Suzuka Fujiwara, Katsuhisa Harada, Mahoko Motoike-Hamura, Masashi Sakai, Satoshi Matsubara, Kouji Miyazaki
Glycation, a non-enzymatic glycosylation of proteins, induces tissue damage in association with various diseases and aging phenomena. Pentosidine, an advanced glycation end product, is involved in aging phenomena such as tissue stiffness. In this study, we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial. From among 681 hot water plant extracts, lemon balm (Melissa officinalis; LB) leaf extract was selected and revealed to have more potent inhibitory activity for pentosidine formation than a representative anti-glycation agent, aminoguanidine...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28361983/inhibitory-potential-of-constituents-from-osmanthus-fragrans-and-structural-analogues-against-advanced-glycation-end-products-%C3%AE-amylase-%C3%AE-glucosidase-and-oxidative-stress
#3
Ji-Yeon Yang, Jun-Hwan Park, Namhyun Chung, Hoi-Seon Lee
Inhibition of α-amylase and α-glucosidase, advanced glycation end products (AGEs) formation, and oxidative stress by isolated active constituents of Osmanthus fragrans flowers (9,12-octadecadienoic acid and 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one) and their structural analogues were evaluated. 9,12-Octadecadienoic acid was 10.02 and 22.21 times more active against α-amylase and α-glucosidase, respectively, than acarbose and ascorbic acid, followed by 9,12,15-octadecatrienoic acid, 9-octadecenoic acid, 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one, 4-(2,6,6-trimethyl-2-cyclohexenyl)-3-buten-2-one, 1-heptadecanecarboxylic acid, and 1-pentadecanecarboxylic acid...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28360443/protective-effect-of-edaravone-against-cyclosporine-induced-chronic-nephropathy-through-antioxidant-and-nitric-oxide-modulating-pathways-in-rats
#4
Elahe Sattarinezhad, Mohammad Reza Panjehshahin, Simin Torabinezhad, Eskandar Kamali-Sarvestani, Shirin Farjadian, Fatema Pirsalami, Leila Moezi
BACKGROUND: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity. The present study evaluates the protective effect of edaravone on CsA-induced chronic nephropathy and investigates its antioxidant and nitric oxide modulating property. METHODS: Male Sprague-Dawley rats (n=66) were distributed into nine groups, including a control (group 1) (n=7)...
March 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28355482/%C3%AE-aminobutyric-acid-gaba-accumulation-in-tea-camellia-sinensis-l-through-the-gaba-shunt-and-polyamine-degradation-pathways-under-anoxia
#5
Jieren Liao, Xiayuan Wu, Zhiqiang Xing, Qinghui Li, Yu Duan, Wanping Fang, Xujun Zhu
γ-Aminobutyric acid (GABA) is an important bioactive component of tea (Camellia sinensis) providing various health benefits. We studied GABA accumulation via the GABA shunt and polyamine degradation pathways under anoxia in tea leaves. Anoxia caused a ∼20-fold increment in GABA concentration, relative to fresh tea leaves. This increment was due to the increase of glutamate decarboxylase and diamine oxidase activities. Genes involved in GABA formation, such as CsGAD1 and CsGAD2, were significantly up-regulated by anoxia...
April 4, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28342847/na-k-atpase-interaction-with-methylglyoxal-as-reactive-metabolic-side-product
#6
Marika Svrckova, Martina Zatloukalova, Petra Dvorakova, Dominika Coufalova, David Novak, Lenka Hernychova, Jan Vacek
Proteins are subject to oxidative modification and the formation of adducts with a broad spectrum of reactive species via enzymatic and non-enzymatic mechanisms. Here we report that in vitro non-enzymatic methylglyoxal (MGO) binding causes the inhibition and formation of MGO advanced glycation end-products (MAGEs) in Na(+)/K(+)-ATPase (NKA). Concretely, MGO adducts with NKA amino acid residues (mainly Arg) and N(ε)-(carboxymethyl)lysine (CML) formation were found. MGO is not only an inhibitor for solubilized NKA (IC50=91±16μM), but also for reconstituted NKA in the lipid bilayer environment, which was clearly demonstrated using a DPPC/DPPE liposome model in the presence or absence of the NKA-selective inhibitor ouabain...
March 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28328190/effects-of-nitric-oxide-inhibitors-in-mice-with-bladder-outlet-obstruction
#7
Marcy Lancia Pereira, Carlos Arturo Levi D'ancona, Julio Alejandro Rojas-Moscoso, Antonio Celso Saragossa Ramos, Fabiola Zakia Monica, Edson Antunes
PURPOSE: To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks of partial bladder outlet obstruction (BOO), in order to evaluate the role of constitutive and non-constitutive NOS in the pathogenesis of this experimental condition. MATERIALS AND METHODS: C57BL6 male mice were partially obstructed and randomly allocated into 6 groups: Sham, Sham + L-NAME, Sham + aminoguanidine, BOO, BOO + L-NAME and BOO + aminoguanidine...
March 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28326319/inhibitory-activities-of-stauntonia-hexaphylla-leaf-constituents-on-rat-lens-aldose-reductase-and-formation-of-advanced-glycation-end-products-and-antioxidant
#8
Seung Hwan Hwang, Shin Hwa Kwon, Set Byeol Kim, Soon Sung Lim
Stauntonia hexaphylla (Thunb.) Decne. (Lardizabalaceae) leaves (SHL) have been used traditionally as analgesics, sedatives, diuretics, and so on, in China. To date, no data have been reported on the inhibitory effect of SHL and its constituents on rat lens aldose reductase (RLAR) and advanced glycation end products (AGEs). Therefore, the inhibitory effect of compounds isolated from SHL extract on RLAR and AGEs was investigated to evaluate potential treatments of diabetic complications. The ethyl acetate (EtOAC) fraction of SHL extract showed strong inhibitory activity on RLAR and AGEs; therefore, EtOAc fraction (3...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28274869/effective-inhibition-of-protein-glycation-by-combinatorial-usage-of-limonene-and-aminoguanidine-through-differential-and-synergistic-mechanisms
#9
Madhav M Joglekar, Laxman N Bavkar, Srinivas Sistla, Akalpita U Arvindekar
Protein glycation is a major mechanism for establishing secondary complication in diabetes mellitus. Effective inhibition of this process can prevent progression of the disorder into secondary complications. Aminoguanidine (AMG) and limonene (LM) are known protein glycation inhibitors. The aim of the present study was to demonstrate their differential mechanisms of action and to study whether combinatorial therapy can act synergistically and lower dosage, and thereby lower toxicity in treatment of secondary complications in diabetes...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28255209/do-advanced-glycation-end-products-and-its-receptor-play-a-role-in-pathophysiology-of-hypertension
#10
REVIEW
Kailash Prasad, Manish Mishra
There is a close relationship between arterial stiffness and blood pressure. The studies suggest that the advanced glycation end products (AGEs) and its cell receptor (RAGE) are involved in the arterial stiffness in two ways: changes in arterial structure and vascular function. Plasma levels of AGEs and expression of RAGE are elevated, while the levels of soluble RAGE (sRAGE) and endogenous secretory RAGE (esRAGE) are lowered in patients with hypertension (HTN). There is a positive correlation between plasma levels of AGEs and arterial stiffness, and an inverse association between arterial stiffness/HTN, and serum levels of sRAGE and esRAGE...
March 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28249208/diphenylurea-derivatives-for-combating-methicillin-and-vancomycin-resistant-staphylococcus-aureus
#11
Ibrahim H Eissa, Haroon Mohammad, Omar A Qassem, Waleed Younis, Tamer M Abdelghany, Ahmed Elshafeey, Mahmoud M Abd Rabo Moustafa, Mohamed N Seleem, Abdelrahman S Mayhoub
A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound 3 that carries an aminoguanidine functionality from one side and a n-butyl moiety on the other ring, several analogues were prepared. Considering the pharmacokinetic parameters as a key factor in structural optimization, the structure-activity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analogue 21n as a potential drug-candidate...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28248504/phenylthiazole-antibacterial-agents-targeting-cell-wall-synthesis-exhibit-potent-activity-in-vitro-and-in-vivo-against-vancomycin-resistant-enterococci
#12
Haroon Mohammad, Waleed Younis, Lu Chen, Christine E Peters, Joe Pogliano, Kit Pogliano, Bruce Cooper, Jianan Zhang, Abdelrahman Mayhoub, Eric Oldfield, Mark Cushman, Mohamed N Seleem
The emergence of antibiotic-resistant bacterial species, such as vancomycin-resistant enterococci (VRE), necessitates the development of new antimicrobials. Here, we investigate the spectrum of antibacterial activity of three phenylthiazole-substituted aminoguanidines. These compounds possess potent activity against VRE, inhibiting growth of clinical isolates at concentrations as low as 0.5 μg/mL. The compounds exerted a rapid bactericidal effect, targeting cell wall synthesis. Transposon mutagenesis suggested three possible targets: YubA, YubB (undecaprenyl diphosphate phosphatase (UPPP)), and YubD...
March 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28242543/multiple-pharmacological-targets-cytotoxicity-and-phytochemical-profile-of-aphloia-theiformis-vahl-benn
#13
Marie Carene Nancy Picot, Onur Bender, Arzu Atalay, Gokhan Zengin, Loïc Loffredo, Francis Hadji-Minaglou, Mohamad Fawzi Mahomoodally
Aphloia theiformis (Vahl.) Benn. (AT) is traditionally used in Sub-Saharan African countries including Mauritius as a biomedicine for the management of several diseases. However, there is a dearth of experimental studies to validate these claims. We endeavoured to evaluate the inhibitory effects of crude aqueous extract as traditionally used together with the crude methanol extracts of AT leaves on urease, angiotensin (I) converting enzyme (ACE), acetylcholinesterase (AChE), cholesterol esterase (CEase), glycogen phosphorylase a (GPa), and glycation in vitro...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28242320/a-positive-feedback-loop-between-nitric-oxide-and-amyloid-%C3%AE-1-42-accelerates-mitochondrial-damage-in-human-lens-epithelial-cells
#14
Noriaki Nagai, Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki
We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) production in mammalian lenses, and that Aβ1-42 stimulates inducible nitric oxide synthase (iNOS) promoter activity. Based on these reports, we investigated the relationship between NO and Aβ1-42 production in human lens epithelial (HLE) cells...
April 15, 2017: Toxicology
https://www.readbyqxmd.com/read/28228071/a-rat-model-of-ischemic-enteritis-pathogenic-importance-of-enterobacteria-inos-no-and-cox-2-pge2
#15
Koji Takeuchi, Yoshino Komatsu, Yuka Nakamori, Tohru Kotani
BACKGROUND: We introduced a rat model of ischemic enteritis and investigated the roles of enterobacteria, nitric oxide (NO), and prostaglandins (PGs) in its pathogenesis. METHODS: Male rats were used after 18 h of fasting. Ischemic enteritis was induced by partial ligation of the superior mesenteric artery (SMA). Under ether anesthesia, SMA was isolated, and a stenosis was made by placing a needle (23 guage) on the vessel and ligating both the vessel and needle, and then a needle was removed from the ligature...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28223158/aminoguanidine-alleviated-mma-induced-impairment-of-cognitive-ability-in-rats-by-downregulating-oxidative-stress-and-inflammatory-reaction
#16
Qiliang Li, Wenqi Song, Ze Tian, Peichang Wang
Methylmalonic acidemia (MMA) is the most common organic acidemia in childhood. Many "treated" patients continued to display various degrees of mental retardation and psychomotor delay, which could be caused by brain damage from elevated oxidative stress. Aminoguanidine (AG), a synthetic antioxidant, was tested in a MMA rat model for its potential therapeutic effects on memory impairment. The effects of AG on MMA-induced cognitive impairment in Wistar rats were evaluated with Morris Water Maze. The levels of nerve cell apoptosis and microglial activation were investigated to illustrate the mechanisms of the improvement of cognition with AG treatment in MMA rats...
February 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28150470/jakyakgamcho-tang-and-its-major-component-paeonia-lactiflora-exhibit-potent-anti-glycation-properties
#17
Junghyun Kim, Chan-Sik Kim, Young Sook Kim, Ik Soo Lee, Jin Sook Kim
Purpose: Advanced glycation end products (AGEs) have been implicated in the pathogenesis of diabetes and other age-related diseases. AGE inhibitors or breakers, such as aminoguanidine and alagebrium, have been proposed as therapeutic agents for AGE-related disorders. Jakyakgamcho-tang (JGT) is a well-known traditional herbal formula, which consists of the radix of Paeonia lactiflora Pallas (PR) and the radix and rhizome of Glycyrrhiza uralensis Fisch (GR). The purpose of this study was to evaluate the inhibitory and breaking activities of JGT, PR, and GR against AGEs...
December 31, 2016: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28132874/glycation-inhibitors-extend-yeast-chronological-lifespan-by-reducing-advanced-glycation-end-products-and-by-back-regulation-of-proteins-involved-in-mitochondrial-respiration
#18
Rubina S Kazi, Reema M Banarjee, Arati B Deshmukh, Gouri V Patil, Mashanipalya G Jagadeeshaprasad, Mahesh J Kulkarni
Advanced Glycation End products (AGEs) are implicated in aging process. Thus, reducing AGEs by using glycation inhibitors may help in attenuating the aging process. In this study using Saccharomyces cerevisiae yeast system, we show that Aminoguanidine (AMG), a well-known glycation inhibitor, decreases the AGE modification of proteins in non-calorie restriction (NR) (2% glucose) and extends chronological lifespan (CLS) similar to that of calorie restriction (CR) condition (0.5% glucose). Proteomic analysis revealed that AMG back regulates the expression of differentially expressed proteins especially those involved in mitochondrial respiration in NR condition, suggesting that it switches metabolism from fermentation to respiration, mimicking CR...
March 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28122174/synthesis-qsar-studies-and-metabolic-stability-of-novel-2-alkylthio-4-chloro-n-5-oxo-4-5-dihydro-1-2-4-triazin-3-yl-benzenesulfonamide-derivatives-as-potential-anticancer-and-apoptosis-inducing-agents
#19
Beata Żołnowska, Jarosław Sławiński, Aneta Pogorzelska, Krzysztof Szafrański, Anna Kawiak, Grzegorz Stasiłojć, Mariusz Belka, Joanna Zielińska, Tomasz Bączek
A series of novel 2-alkylthio-4-chloro-N-(5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)benzenesulfonamide derivatives 12-46 have been synthesized by the reaction of aminoguanidines with an appropriate alpha-oxo-acids hydrates in glacial acetic acid. All the synthesized compounds were evaluated for their anticancer activity against HeLa, HCT-116, and MCF-7 human tumor cell lines. Two compounds 33 and 34 displayed outstanding cytotoxic effect selectively toward HeLa cancer cells (IC50  = 19 μm) and did not exhibit toxicity to the non-cancerous HaCaT cells...
January 25, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28105567/effects-of-oleuropein-on-pentylenetetrazol-induced-seizures-in-mice-involvement-of-opioidergic-and-nitrergic-systems
#20
Nastaran Rahimi, Bahram Delfan, Nazgol Motamed-Gorji, Ahmad R Dehpour
Oleuropein, a well-known olive polyphenol, has been shown to mediate neuroprotection in Alzheimer's disease and cerebral ischemia. We investigated the effects of oleuropein on pentylenetetrazole (PTZ)-induced seizures in male NMRI mice, with diazepam as the standard drug. We also examined the possible involvement of opioidergic/nitrergic pathways in the probable effects of oleuropein. Intraperitoneal (i.p.) administration of different doses of oleuropein (10, 20 and 30 mg/kg) significantly increased the seizure threshold 60 min prior to induction of seizure, in a dose-dependent manner...
April 2017: Journal of Natural Medicines
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