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aminoguanidine

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https://www.readbyqxmd.com/read/29453978/venlafaxine-prevents-morphine-antinociceptive-tolerance-the-role-of-neuroinflammation-and-the-l-arginine-nitric-oxide-pathway
#1
Mohammad Taghi Mansouri, Bahareh Naghizadeh, Behnam Ghorbanzadeh, Soheila Alboghobeish, Neda Amirgholami, Gholamreza Houshmand, Omar Cauli
Opioid-induced neuroinflammation and the nitric oxide (NO) signal-transduction pathway are involved in the development of opioid analgesic tolerance. The antidepressant venlafaxine (VLF) modulates NO in nervous tissues, and so we investigated its effect on induced tolerance to morphine, neuroinflammation, and oxidative stress in mice. Tolerance to the analgesic effects of morphine were induced by injecting mice with morphine (50 mg/kg) once a day for three consecutive days; the effect of co-administration of VLF (5 or 40 mg/kg) with morphine was similarly tested in a separate group...
February 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29437543/acute-copper-overload-induces-vascular-dysfunction-in-aortic-rings-due-to-endothelial-oxidative-stress-and-increased-nitric-oxide-production
#2
Karolini Zuqui Nunes, Mirian Fioresi, Vinicius Bermond Marques, Dalton Valentim Vassallo
The mechanisms involved in vascular reactivity alterations promoted by copper (Cu) overload were investigated. Thoracic aorta obtained from male Wistar rats were cut into rings and exposed for 1 h to 10 µg/ml Cu. Exposure to Cu decreased the contractile responses of aortic rings to phenylephrine (PHE). Removal of endothelium and subsequent administration of N-nitro-L arginine methyl ester (L-NAME), tetrahydrobiopterin, aminoguanidine, diethyldithiocarbamic acid, catalase, or tetraethylammonium increased contractile responses...
February 13, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29421244/involvement-of-no-nmda-r-pathway-in-the-behavioral-despair-induced-by-amphetamine-withdrawal
#3
Arvin Haj-Mirzaian, Shayan Amiri, Hossein Amini-Khoei, Arya Haj-Mirzaian, Arsalan Hashemiaghdam, Kiana Ramezanzadeh, Maria Ghesmati, Khashayar Afshari, Ahmad Reza Dehpour
Abrupt discontinuation of chronic amphetamine consumption leads to withdrawal symptoms including depression, anhedonia, dysphoria, fatigue, and anxiety. These irritating symptoms may result in continuing to take the drug or can lead to suicidal behavior. Past studies have shown the involvement of various biologic systems in depression induced following amphetamine withdrawal (AW). However, there is no evidence about the relation between nitric oxide (NO) with NMDA receptors on depression following AW. In this study, we examined the involvement of the NO/NMDA pathways on depressive-like behaviors after 24 h withdrawal following 5 continuous days of amphetamine administration in male NMRI mice...
February 5, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29408007/neuropharmacological-characterization-of-frutalin-in-mice-evidence-of-an-antidepressant-like-effect-mediated-by-the-nmda-receptor-no-cgmp-pathway
#4
João Ronielly Campêlo Araújo, José de Maria Albuquerque de Melo Júnior, Marina de Barros Mamede Vidal Damasceno, Sacha Aubrey Alves Rodrigues Santos, Antônio Eufrásio Vieira-Neto, Marina Duarte Pinto Lobo, Adriana Rolim Campos, Renato de Azevedo Moreira, Ana Cristina de Oliveira Monteiro-Moreira
In this study we evaluated the effect of frutalin (FTL) on mouse behavior. Mice (n = 6/group) were treated (i.p.) with FTL (0.25; 0.5 or 1 mg/kg) or vehicle and submitted to several tests (hole-board/HBT, elevated plus maze/PMT, open field/OFT, tail suspension/TST, or forced swimming/FST). Yohimbine, ketamine, l-NAME, aminoguanidine, 7-NI, methylene blue, l-arginine or dl-serine was administered 30 min before FTL (0.5 mg/kg). To evaluate the subchronic effect, animals were injected with FTL or vehicle for 7 days and submitted to the FST...
January 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29400329/formaldehyde-aminoguanidine-condensation-and-aminoguanidine-self-condensation-products-syntheses-crystal-structures-and-characterization
#5
Elena A Buvaylo, Vladimir N Kokozay, Nataliia Yu Strutynska, Olga Yu Vassilyeva, Brian W Skelton
Guanidine is the functional group on the side chain of arginine, one of the fundamental building blocks of life. In recent years, a number of compounds based on the aminoguanidine (AG) moiety have been described as presenting high anticancer activities. The product of condensation between two molecules of AG and one molecule of formaldehyde was isolated in the protonated form as the dinitrate salt (systematic name: 2,8-diamino-1,3,4,6,7,9-hexaazanona-1,8-diene-1,9-diium dinitrate), C3H14N82+·2NO3-, (I). The cation lacks crystallographically imposed symmetry and comprises two terminal planar guanidinium groups, which share an N-C-N unit...
February 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29363586/guanabenz-inhibits-tlr9-signaling-through-a-pathway-that-is-independent-of-eif2%C3%AE-dephosphorylation-by-the-gadd34-pp1c-complex
#6
Jessica Perego, Andreia Mendes, Clarisse Bourbon, Voahirana Camosseto, Alexis Combes, Hong Liu, Thien-Phong Vu Manh, Alexandre Dalet, Lionel Chasson, Lionel Spinelli, Nathalie Bardin, Laurent Chiche, Manuel A S Santos, Evelina Gatti, Philippe Pierre
Endoplasmic reticulum (ER) stress triggers or amplifies inflammatory signals and cytokine production in immune cells. Upon the resolution of ER stress, the inducible phosphatase 1 cofactor GADD34 promotes the dephosphorylation of the initiation factor eIF2α, thereby enabling protein translation to resume. Several aminoguanidine compounds, such as guanabenz, perturb the eIF2α phosphorylation-dephosphorylation cycle and protect different cell or tissue types from protein misfolding and degeneration. We investigated how pharmacological interference with the eIF2α pathway could be beneficial to treat autoinflammatory diseases dependent on proinflammatory cytokines and type I interferons (IFNs), the production of which is regulated by GADD34 in dendritic cells (DCs)...
January 23, 2018: Science Signaling
https://www.readbyqxmd.com/read/29363521/the-effect-of-aminoguanidine-ag-and-pyridoxamine-pm-on-ageing-human-cortical-bone
#7
O Abar, S Dharmar, S Y Tang
OBJECTIVES: Advanced glycation end-products (AGEs) are a post-translational modification of collagen that form spontaneously in the skeletal matrix due to the presence of reducing sugars, such as glucose. The accumulation of AGEs leads to collagen cross-linking, which adversely affects bone quality and has been shown to play a major role in fracture risk. Thus, intervening in the formation and accumulation of AGEs may be a viable means of protecting bone quality. METHODS: An in vitro model was used to examine the efficacy of two AGE-inhibitors, aminoguanidine (AG) and pyridoxamine (PM), on ageing human cortical bone...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29353375/comparative-effects-of-hydrogen-sulfide-releasing-compounds-on-3h-d-aspartate-release-from-bovine-isolated-retinae
#8
Pratik Bankhele, Ankita Salvi, Jamal Jamil, Fatou Njie-Mbye, Sunny Ohia, Catherine A Opere
We investigated the pharmacological actions of a slow-releasing H2S donor, GYY 4137; a substrate for the biosynthesis of H2S, L-cysteine and its precursor, N-acetylcysteine on potassium (K+; 50 mM)-evoked [3H]D-aspartate release from bovine isolated retinae using the Superfusion Method. GYY 4137 (10 nM-10 µM), L-cysteine (100 nM-10 µM) and N-acetylcysteine (10 µM-1 mM) elicited a concentration-dependent decrease in K+-evoked [3H]D-aspartate release from isolated bovine retinae without affecting basal tritium efflux...
January 20, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29323171/new-anti-inflammatory-guaianes-from-the-atlantic-hydrotherm-derived-fungus-graphostroma-sp-mccc-3a00421
#9
Siwen Niu, Chun-Lan Xie, Jin-Mei Xia, Zhu-Hua Luo, Zongze Shao, Xian-Wen Yang
Nine new guaianes (graphostromanes A-I, 1-9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10-13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were assigned using the X-ray crystallography and modified Mosher's method. All isolates were evaluated for their inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29259041/paeonol-attenuates-lps-induced-endothelial-dysfunction-and-apoptosis-by-inhibiting-bmp4-and-tlr4-signalling-simultaneously-but-independently
#10
Ker Woon Choy, Yeh Siang Lau, Dharmani Murugan, Paul M Vanhoutte, Mohd Rais Mustafa
Inflammatory injury of the endothelium leads to apoptosis and endothelial dysfunction. The current study explored the effect and mechanisms of paeonol in inflammation-induced apoptosis and endothelial dysfunction induced by lipopolysaccharides (LPS). The effects of paeonol on LPS-induced inflammatory injury were assessed by Western blotting, flow cytometry and reactive oxygen species (ROS) measurement in human umbilical vein endothelial cells (HUVECs) and C57BL/6J mice. Vascular reactivity of isolated mouse aortae was examined using wire myographs...
December 19, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29229986/high-fat-diet-induced-obesity-impairs-insulin-signaling-in-lungs-of-allergen-challenged-mice-improvement-by-resveratrol
#11
Diana M André, Marina C Calixto, Carolina Sollon, Eduardo C Alexandre, Edith B G Tavares, Ana C A Naime, Gabriel F Anhê, Edson Antunes
Insulin resistance plays an important role in obesity-associated asthma exacerbations. Using a murine model of allergic airway inflammation, we evaluated the insulin signaling transmission in lungs of obese compared with lean mice. We further evaluated the effects of the polyphenol resveratrol in the pulmonary insulin signaling. In lean mice, insulin stimulation significantly increased phosphorylations of AKT, insulin receptor substrate 1 (IRS-1) and insulin receptor β (IRβ) in lung tissue and isolated bronchi (p < 0...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228430/mediation-of-inflammation-obesity-and-fatty-liver-disease-by-advanced-glycation-endoproducts
#12
D-D Xiong, M Zhang, N Li, J-F Gai, L Mao, M Li
OBJECTIVE: Fatty liver may induce various complications including chronic hepatitis or liver cirrhosis, and is frequently occurred in obesity individuals. Advanced glycosylation end products (AGEs) were known to play a critical role in multiple liver diseases. This study, therefore, aimed to study the effect of AGEs on obesity, related liver cirrhosis and inflammation, on an obesity fatty liver rat model. MATERIALS AND METHODS: A total of 60 Sprague Dawley (SD) rats were randomly divided into control, model and AGEs inhibitor groups (n=20 each)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29208359/aminoguanidine-hydrazones-agh-s-as-modulators-of-norfloxacin-resistance-in-staphylococcus-aureus-that-overexpress-nora-efflux-pump
#13
Natalina Dantas, Thiago Mendonça de Aquino, João Xavier de Araújo-Júnior, Edeildo da Silva-Júnior, Ednaldo Almeida Gomes, Antoniel Augustos Severo Gomes, José Pinto Siqueira-Júnior, Francisco Jaime Bezerra Mendonça Junior
One of the promising fields for improving the effectiveness of antimicrobial agents is their combination with efflux pump inhibitors (EPIs), which besides expanding the use of existing antibiotics. The goal of this research was to evaluate a series of aminoguanidine hydrazones (AGH's, 1-19) as antibacterial agents and NorA efflux pump inhibitors in Staphylococcus aureus strain SA-1199B. Molecular modeling and docking studies were also performed in order to explain at the molecular level the interactions of the compounds with the generated NorA efflux pump model...
December 2, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29181125/protective-effects-and-possible-mechanisms-of-ergothioneine-and-hispidin-against-methylglyoxal-induced-injuries-in-rat-pheochromocytoma-cells
#14
Tuzz-Ying Song, Nae-Cherng Yang, Chien-Lin Chen, Thuy Lan Vo Thi
Diabetic encephalopathy (DE) is often a complication in patients with Alzheimer's disease due to high blood sugar induced by diabetic mellitus. Ergothioneine (EGT) and hispidin (HIP) are antioxidants present in Phellinus linteus. Methylglyoxal (MGO), a toxic precursor of advanced glycated end products (AGEs), is responsible for protein glycation. We investigated whether a combination EGT and HIP (EGT + HIP) protects against MGO-induced neuronal cell damage. Rat pheochromocytoma (PC12) cells were preincubated with EGT (2 μM), HIP (2 μM), or EGT + HIP, then challenged with MGO under high-glucose condition (30 μM MGO + 30 mM glucose; GLU + MGO) for 24-96 h...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29174818/inhibition-of-advanced-glycation-endproduct-age-rescues-against-streptozotocin-induced-diabetic-cardiomyopathy-role-of-autophagy-and-er-stress
#15
Zhaohui Pei, Qinqin Deng, Sara A Babcock, Emily Y He, Jun Ren, Yingmei Zhang
Diabetes mellitus leads to oxidative stress and contractile dysfunction in the heart. Although several rationales have been speculated, the precise mechanism behind diabetic cardiomyopathy remains elusive. This study was designed to assess the role of inhibition of advanced glycation endproducts (AGE) in streptozotocin (STZ)-induced diabetic cardiac dysfunction. Cardiac contractile function was assessed in normal C57BL/6 and STZ (200mg/kg, single injection and maintained for 2 wks)-induced diabetic mice treated with or without the AGE inhibitor aminoguanidine (50mg/kg/d in drinking water) for 2 weeks using echocardiography and IonOptix MyoCam techniques...
November 22, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29170525/advanced-glycation-endproducts-link-inflammatory-cues-to-upregulation-of-galectin-1-in-diabetic-retinopathy
#16
Atsuhiro Kanda, Yoko Dong, Kousuke Noda, Wataru Saito, Susumu Ishida
Diabetic retinopathy (DR) is an inflammatory and progressive vaso-occlusive disease resulting in angiogenesis. Galectin-1 is a hypoxia-induced angiogenic factor associated with cancer and proliferative DR. Here we reveal a significant upregulation of galectin-1 in eyes of DR patients along with progression of clinical stages beginning from the pre-ischemic, inflammatory stage with diabetic macular edema, but not in eyes with non-diabetic retinal vascular occlusions. As for its regulatory mechanism unrelated to hypoxia but selective to DR, in vitro galectin-1/LGALS1 expression was shown to increase after application to Müller glial cells with interleukin (IL)-1β, which was induced in monocyte-derived macrophages and microglial cells via toll-like receptor (TLR) 4 signaling stimulated by advanced glycation endproducts (AGE)...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29168862/inhibition-of-advanced-glycation-endproducts-during-fish-sausage-preparation-by-transglutaminase-and-chitosan-oligosaccharides-induced-enzymatic-glycosylation
#17
Jing Wang, Long Zou, Fangzhou Yuan, Liangtao Lv, Shenglan Tian, Zhenxing Li, Hong Lin
Advanced glycation endproducts (AGEs) are the harmful products of non-enzymatic reactions in foods formed during the heating process. In order to reduce the content of AGEs in foods, the inhibitory effect of different proportions of transglutaminase (TGase) and chitosan oligosaccharides (COS) on the AGEs of seabream fish meat sausage was studied. The results indicated that the TGase/COS ratio of 1 : 1 could inhibit the formation of AGEs, showing especially a decreased N(ε)-carboxymethyl-lysine (CML) content and a twice higher inhibition rate (36...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29165729/polyphenols-from-euphorbia-pekinensis-inhibit-ages-formation-in-vitro-and-vessel-dilation-in-larval-zebrafish-in-vivo
#18
Ik-Soo Lee, Seung-Hyun Jung, Jin Sook Kim
To identify active compounds in the roots of Euphorbia pekinensis for treatment of diabetic complications, an active column fraction from a 70% EtOH extract of E. pekinensis root was purified by preparative reversed-phase high-performance liquid chromatography, leading to the isolation of a new ellagic acid derivative, 3,3'-di-O-methylellagic acid 4-O-(6"-O-galloyl)-β-D-galactopyranoside (1), along with three known compounds, geraniin (2), 3,3'-di-O-methylellagic acid 4-O-β-D-xylopyranoside (3), and ellagic acid 3,3'-dimethyl ether (4)...
November 17, 2017: Planta Medica
https://www.readbyqxmd.com/read/29152780/6-nitroazolo-1-5-a-pyrimidin-7-4h-ones-as-antidiabetic-agents
#19
Alexander A Spasov, Denis A Babkov, Valentina A Sysoeva, Roman A Litvinov, Darya D Shamshina, Evgeny N Ulomsky, Konstantin V Savateev, Viktor V Fedotov, Pavel A Slepukhin, Oleg N Chupakhin, Valery N Charushin, Vladimir L Rusinov
Prevention of the formation of advanced glycation end-products (AGEs) is a reliable approach to achieve control over hyperglycemia and the associated pathogenesis of diabetic vascular complications. In these terms, new synthetic approaches to 6-nitroazolo[1,5-a]pyrimidines have been developed on the basis of the promising antiglycation activity of their structural analogues, such as azolo[5,1-c][1,2,4]triazine-4(1H)-ones. A number of nitroazolopyrimidines were obtained by using nitration, chlorodeoxygenation, and amination reactions, and their antidiabetic properties were elucidated in vitro...
November 20, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29111523/the-synthesis-crystal-structure-and-thermal-properties-of-an-energetic-compound-the-hydrated-azanium-salt-of-3-6-bis-1h-1-2-3-4-tetrazol-5-yl-amino-1-2-4-5-tetrazine
#20
Qing Liu, Xiang Chen, Wenli Cao, Jin Yang, Wenhui Zhang, Yinghui Ren, Haixia Ma, Fengqi Zhao, Rongzu Hu
The energetic ionic salt bis(1-aminoguanidin-2-ium) 5,5'-[1,2,4,5-tetrazine-3,6-diylbis(azanediyl)]bis(1H-1,2,3,4-tetrazol-1-ide) dihydrate, 2CH7N4(+)·C4H2N14(2-)·2H2O, (I), with a high nitrogen content, has been synthesized and examined by elemental analysis, Fourier transform IR spectrometry, (1)H NMR spectroscopy and single-crystal X-ray crystallography. Compound (I) crystallizes in the monoclinic space group P21/c with two water molecules. However, the water molecules are disordered about an inversion centre and were modelled as half-occupancy molecules in the structure...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
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