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aminoguanidine

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https://www.readbyqxmd.com/read/28726197/effect-of-phenibut-and-glufimet-a-novel-glutamic-acid-derivative-on-respiration-of-heart-and-brain-mitochondria-from-animals-exposed-to-stress-against-the-background-of-inducible-no-synthase-blockade
#1
V N Perfilova, T A Popova, I I Prokofiev, I S Mokrousov, O V Ostrovskii, I N Tyurenkov
Increased oxygen consumption by heart and brain mitochondria in the absence of ADP and reduced mitochondrial respiration in the presence of ADP were observed in rats exposed to stress simulated by suspension by the dorsal neck skin fold for 24 h, which attests to uncoupling of substrate oxidation and ATP synthesis and can cause electron drain from the respiratory chain, formation of ROS, and oxidative damage to cell structures. Blockade of inducible NO synthase with aminoguanidine (single intraperitoneal dose of 50 mg/kg before stress exposure) increased coupling of respiration and oxidative phosphorylation in heart and brain mitochondria of rats exposed to immobilization-painful stress, which was especially pronounced in cardiomyocytes...
July 18, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28704798/experimental-studies-on-possible-regulatory-role-of-nitric-oxide-on-the-differential-effects-of-chronic-predictable-and-unpredictable-stress-on-adaptive-immune-responses
#2
Tarun Thakur, Kavita Gulati, Nishant Rai, Arunabha Ray
The present study was designed to investigate the effects of chronic predictable stress (CPS) and chronic unpredictable stress (CUS) on immunological responses in KLH-sensitized rats and involvement of NOergic signaling pathways mediating such responses. Male Wistar rats (200-250g) were exposed to either CPS or CUS for 14days and IgG antibody levels and delayed type hypersensitivity (DTH) response was determined to assess changes in adaptive immunity. To evaluate the role of nitric oxide during such immunomodulation, biochemical estimation of stable metabolite of nitric oxide (NOx) and 3-nitrotyrosine (3-NT, a marker of peroxynitrite formation) were done in both blood and brain...
July 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28704619/advanced-glycation-end-products-affect-cholesterol-homeostasis-by-impairing-abca1-expression-on-macrophages
#3
Olivier Kamtchueng Simo, Souade Ikhlef, Hicham Berrougui, Abdelouahed Khalil
Reverse cholesterol transport (RCT), which is intimately linked to high-density lipoproteins (HDLs), plays a key role in cholesterol homeostasis and the prevention of atherosclerosis. The goal of the present study was to investigate the effect of aging and advanced glycation end products (AGEs) on RCT as well as on other factors that may affect this anti-atherogenic property of HDLs. The transfer of macrophage-derived cholesterol to the plasma and liver and then to the feces for elimination was significantly lower in aged mice than in young mice...
July 13, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28698893/cytotoxicity-against-tumor-cell-lines-and-anti-inflammatory-properties-of-chitinases-from-calotropis-procera-latex
#4
Carolina Araújo Viana, Márcio V Ramos, José Delano Barreto Marinho Filho, Letícia Veras Costa Lotufo, Ingrid Samantha Tavares Figueiredo, Jefferson Soares de Oliveira, Pietro Mastroeni, José Vitor Lima-Filho, Nylane Maria Nunes Alencar
The role of chitinases from the latex of medicinal shrub Calotropis procera on viability of tumor cell lines and inflammation was investigated. Soluble latex proteins were fractionated in a CM Sepharose Fast-Flow Column and the major peak (LPp1) subjected to ion exchange chromatography using a Mono-Q column coupled to an FPLC system. In a first series of experiments, immortalized macrophages were cultured with LPp1 for 24 h. Then, cytotoxicity of chitinase isoforms (LPp1-P1 to P6) was evaluated against HCT-116 (colon carcinoma), OVCAR-8 (ovarian carcinoma), and SF-295 (glioblastoma) tumor cell lines in 96-well plates...
July 11, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28694192/laminar-shear-stress-suppresses-vascular-smooth-muscle-cell-proliferation-through-nitric-oxide-ampk-pathway
#5
Sun Ae Kim, Jin Young Sung, Chang Hoon Woo, Hyoung Chul Choi
In healthy condition, vascular smooth muscle cells (VSMCs) are not directly exposed to shear stresses, because they are shielded by endothelial cell (EC) layer that lines blood vessels. After injury to EC layer caused by rupture of atherosclerotic lesions or invasive techniques such as angioplasty, VSMCs are directly exposed to blood flow which modulate molecular signaling and function. In endothelium, exposure to fluid shear stress has been reported to induce AMP-activated protein kinase (AMPK) phosphorylation and nitric oxide (NO) production...
July 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28685011/methylglyoxal-induces-changes-in-the-glyoxalase-system-and-impairs-glutamate-uptake-activity-in-primary-astrocytes
#6
Fernanda Hansen, Fabiana Galland, Franciane Lirio, Daniela Fraga de Souza, Carollina Da Ré, Rafaela Ferreira Pacheco, Adriana Fernanda Vizuete, André Quincozes-Santos, Marina Concli Leite, Carlos-Alberto Gonçalves
The impairment of astrocyte functions is associated with diabetes mellitus and other neurodegenerative diseases. Astrocytes have been proposed to be essential cells for neuroprotection against elevated levels of methylglyoxal (MG), a highly reactive aldehyde derived from the glycolytic pathway. MG exposure impairs primary astrocyte viability, as evaluated by different assays, and these cells respond to MG elevation by increasing glyoxalase 1 activity and glutathione levels, which improve cell viability and survival...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28659153/advanced-glycation-end-products-ages-increase-renal-lipid-accumulation-a-pathogenic-factor-of-diabetic-nephropathy-dn
#7
Yang Yuan, Hong Sun, Zilin Sun
BACKGROUND: Advanced glycation end products (AGEs) are pathogenic factors of diabetic nephropathy (DN), causing renal damage in various ways. The aim of this study is to investigate the ectopic lipid accumulation caused by AGEs in human renal tubular epithelial cell line (HK-2) cells and the kidney of type 2 diabetic rats. METHODS: In vivo study, diabetes was induced in male Sprague-Dawley rats through intraperitoneal injection of high-fat/high-sucrose diet and low-dose streptozocin (STZ)...
June 28, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28649743/l-arginine-modulates-inflammation-and-muscle-regulatory-genes-after-a-single-session-of-resistance-exercise-in-rats
#8
Samuel R L Morais, Victor Gustavo B Brito, Wagner G Mello, Sandra H P Oliveira
We investigated the skeletal muscle adaptation to L-arginine supplementation prior to a single session of resistance exercise (RE) during the early phase of muscle repair. Wistar rats were randomly assigned into non-exercised (Control), RE plus vehicle (RE); RE plus L-arginine (RE+L-arg) and RE plus aminoguanidine (RE+AG) groups. Animals received four doses of either vehicle (0.9%NaCl), L-arg (1g/b.w.), or AG (iNOS inhibitor) (50mg/b.w.). The animals performed a single RE session until the concentric failure (ladder climbing; 80% overload) and the skeletal muscles were harvested at 0, 8, 24 and 48h post RE...
June 26, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28634786/inhibition-of-nf-%C3%AE%C2%BAb-activity-by-aminoguanidine-alleviates-neuroinflammation-induced-by-hyperglycemia
#9
Yuanjian Song, Fang Zhang, Changjiang Ying, Kiran Ashok Kumar, Xiaoyan Zhou
Neuroinflammation is a key feature of cerebral complication which is associated with diabetes mellitus (DM). Inducible nitric oxide synthase (iNOS) is implicated in the pathogenesis of neuroinflammation. However, how iNOS facilitates the development of inflammation in brain is still unidentified. The aim of the present study was to investigate the association of iNOS and neuroinflammation in diabetic mice, and elucidate the potential mechanisms underlying aminoguanidine (AG), the selective inhibitor of iNOS, protected neurons against inflammation in diabetic mice...
June 20, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28631525/polyphenol-profile-by-uhplc-ms-ms-anti-glycation-antioxidant-and-cytotoxic-activities-of-several-samples-of-propolis-from-the-northeastern-semi-arid-region-of-brazil
#10
Jadriane de Almeida Xavier, Iara Barros Valentim, Fabiana O S Camatari, Alberto M M de Almeida, Henrique Fonseca Goulart, Jamylle Nunes de Souza Ferro, Emiliano de Oliveira Barreto, Bruno Coelho Cavalcanti, Carla B G Bottoli, Marília Oliveira Fonseca Goulart
CONTEXT: Propolis has promising biological activities. Propolis samples from the Northeast of Bahia, Brazil - sample A from Ribeira do Pombal and B, from Tucano - were investigated, with new information regarding their biological activities. OBJECTIVE: This paper describes the chemical profile, antioxidant, anti-glycation and cytotoxic activities of these propolis samples. MATERIAL AND METHODS: Ethanol extracts of these propolis samples (EEP) and their fractions were analyzed to determine total phenolic content (TPC); antioxidant capacity through DPPH(•), FRAP and lipid peroxidation; anti-glycation activity, by an in vitro glucose (10 mg/mL) bovine serum albumine (1 mg/mL) assay, during 7 d; cytotoxic activity on cancer (SF295, HCT-116, OVCAR-8, MDA-MB435, MX-1, MCF7, HL60, JURKAT, MOLT-4, K562, PC3, DU145) and normal cell lines (V79) at 0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28615337/accumulation-of-methylglyoxal-increases-the-advanced-glycation-end-products-levels-in-drg-and-contributes-to-lumbar-disc-herniation-induced-persistent-pain
#11
Cui-Cui Liu, Xin-Sheng Zhang, Yu-Ting Ruan, Zhu-Xi Huang, Su-Bo Zhang, Meng Liu, Hai-Jie Luo, Shao-Ling Wu, Chao Ma
Lumbar disc herniation (LDH) with discogenic low back pain and sciatica is a common and complicated musculoskeletal disorder. The underlying mechanisms are poorly understood and there are no effective therapies for LDH-induced pain. In the present study, we found that the patients who suffered from LDH-induced pain had elevated plasma methylglyoxal (MG) levels. In rats, implantation of autologous nucleus pulposus (NP) to the left lumbar 5 spinal nerve root, which mimicked LDH, induced mechanical allodynia and increased MG level in plasma and dorsal root ganglion (DRG) and enhanced the excitability of small DRG neurons (< 30μm in diameter)...
June 14, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28577109/phosgene-induced-acute-lung-injury-ali-differences-from-chlorine-induced-ali-and-attempts-to-translate-toxicology-to-clinical-medicine
#12
REVIEW
Wenli Li, Juergen Pauluhn
BACKGROUND: Phosgene (carbonyl dichloride) gas is an indispensable chemical inter-mediate used in numerous industrial processes. There is no clear consensus as to its time- and inhaled-dose-dependent etiopathologies and associated preventive or therapeutic treatment strategies. METHODS: Cardiopulmonary function was examined in rats exposed by inhalation to the alveolar irritant phosgene or to the airway irritant chlorine during and following exposure. Terminal measurements focused on hematology, protein extravasation in bronchoalveolar lavage (BAL), and increased lung weight...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28529131/the-structure-of-the-guanidine-ii-riboswitch
#13
Lin Huang, Jia Wang, David M J Lilley
The guanidine-II (mini-ykkC) riboswitch is the smallest of the guanidine-responsive riboswitches, comprising two stem loops of similar sequence. We have solved high-resolution crystal structures of both stem loops for the riboswitch from Gloeobacter violaceus. The stem loops have a strong propensity to dimerize by intimate loop-loop interaction. The dimerization creates specific binding pockets for two guanidine molecules, explaining their cooperative binding. Within the binding pockets the ligands are hydrogen bonded to a guanine at O6 and N7, and to successive backbone phosphates...
June 22, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28527897/advanced-glycation-endproducts-form-during-ovalbumin-digestion-in-the-presence-of-fructose-inhibition-by-chlorogenic-acid
#14
Yasmin Bains, Alejandro Gugliucci, Russell Caccavello
BACKGROUND: One mechanism by which fructose could exert deleterious effects is through intestinal formation and absorption of pro-inflammatory advanced glycation endproducts via the Maillard reaction. We employed simulated stomach and duodenum digestion of ovalbumin (OVA) to test the hypothesis that advanced glycation endproducts (AGEs) are formed by fructose during simulated digestion of a ubiquitous food protein under model physiological conditions. METHODS: OVA was subjected to simulated gastric and intestinal digestion using standard models, in presence of fructose or glucose (0-100mM)...
May 17, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28501696/the-role-of-nitric-oxide-in-anticonvulsant-effect-of-nanocurcumine-on-pentylenetetrazole-induced-seizure-in-mice
#15
Alireza Aminirad, Seyyedeh Elaheh Mousavi, Nahid Fakhraei, Seyyedeh Mahbubeh Mousavi, Seyed Mahdi Rezayat
A plant alkaloid obtained from Curcuma longa, curcumin possesses anti-oxidant and anti-inflammatory effects. Nanoformulations have been developed for preclinical studies which demonstrate enhanced therapeutic efficacy. Effect of acute intraperitoneal (i.p.) administration of curcumin C3 complex nanoparticles [1,5, 10, 20, 40, 80mg/kg, (i.p.)] 75min prior to PTZ, on clonic seizure thresholds induced by intravenous infusion of pentylenetetrazole (PTZ) 0.5% was investigated in comparison with curcumin (40 and 80mg/kg, i...
May 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28488455/intracellular-methylglyoxal-induces-oxidative-damage-to-pancreatic-beta-cell-line-ins-1-cell-through-ire1%C3%AE-jnk-and-mitochondrial-apoptotic-pathway
#16
Chongxiao Liu, Yanhong Huang, Yifan Zhang, Xueru Chen, Xiang Kong, Yan Dong
An increased intracellular methylglyoxal (MGO) under hyperglycemia led to pancreatic beta cell death. However, its mechanism in which way with MGO induced beta cell death remains unknown. We investigated both high glucose and MGO treatment significantly inclined intracellular MGO concentration and inhibited cell viability in vitro. MGO treatment also triggered intracellular advanced glycation end products (AGEs) formation, declined mitochondrial membrane potential (MMP), increased oxidative stress and the expression of ER stress mediators Grp78/Bip and p-PERK; activated mitochondrial apoptotic pathway, which could mimic by Glo1 knockdown...
May 10, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28386146/histological-and-immunohistochemical-basis-of-the-effect-of-aminoguanidine-on-renal-changes-associated-with-hemorrhagic-shock-in-a-rat-model
#17
Abdulmajeed Al Drees, Mahmoud Salah Khalil, Mona Soliman
Acute kidney failure is the main cause of death among patients with severe trauma due to massive blood loss and hemorrhagic shock (HS). Renal cell injury is caused by tissue ischemia. Renal ischemia initiates a complex and interconnected chain of events resulting in cell injury and renal cell necrosis. Nitric oxide plays a crucial role in renal function and can be inhibited by aminoguanidine (AG). We studied whether AG can ameliorate pathological renal changes associated with HS syndrome in a rat model and explored the AG protection mechanism...
February 28, 2017: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/28367927/beneficial-effects-of-lemon-balm-leaf-extract-on-in-vitro-glycation-of-proteins-arterial-stiffness-and-skin-elasticity-in-healthy-adults
#18
Shintaro Yui, Suzuka Fujiwara, Katsuhisa Harada, Mahoko Motoike-Hamura, Masashi Sakai, Satoshi Matsubara, Kouji Miyazaki
Glycation, a non-enzymatic glycosylation of proteins, induces tissue damage in association with various diseases and aging phenomena. Pentosidine, an advanced glycation end product, is involved in aging phenomena such as tissue stiffness. In this study, we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial. From among 681 hot water plant extracts, lemon balm (Melissa officinalis; LB) leaf extract was selected and revealed to have more potent inhibitory activity for pentosidine formation than a representative anti-glycation agent, aminoguanidine...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28361983/inhibitory-potential-of-constituents-from-osmanthus-fragrans-and-structural-analogues-against-advanced-glycation-end-products-%C3%AE-amylase-%C3%AE-glucosidase-and-oxidative-stress
#19
Ji-Yeon Yang, Jun-Hwan Park, Namhyun Chung, Hoi-Seon Lee
Inhibition of α-amylase and α-glucosidase, advanced glycation end products (AGEs) formation, and oxidative stress by isolated active constituents of Osmanthus fragrans flowers (9,12-octadecadienoic acid and 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one) and their structural analogues were evaluated. 9,12-Octadecadienoic acid was 10.02 and 22.21 times more active against α-amylase and α-glucosidase, respectively, than acarbose and ascorbic acid, followed by 9,12,15-octadecatrienoic acid, 9-octadecenoic acid, 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one, 4-(2,6,6-trimethyl-2-cyclohexenyl)-3-buten-2-one, 1-heptadecanecarboxylic acid, and 1-pentadecanecarboxylic acid...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28360443/protective-effect-of-edaravone-against-cyclosporine-induced-chronic-nephropathy-through-antioxidant-and-nitric-oxide-modulating-pathways-in-rats
#20
Elahe Sattarinezhad, Mohammad Reza Panjehshahin, Simin Torabinezhad, Eskandar Kamali-Sarvestani, Shirin Farjadian, Fatema Pirsalami, Leila Moezi
BACKGROUND: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity. The present study evaluates the protective effect of edaravone on CsA-induced chronic nephropathy and investigates its antioxidant and nitric oxide modulating property. METHODS: Male Sprague-Dawley rats (n=66) were distributed into nine groups, including a control (group 1) (n=7)...
March 2017: Iranian Journal of Medical Sciences
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