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aminoguanidine

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https://www.readbyqxmd.com/read/29208359/aminoguanidine-hydrazones-agh-s-as-modulators-of-norfloxacin-resistance-in-staphylococcus-aureus-that-overexpress-nora-efflux-pump
#1
Natalina Dantas, Thiago Mendonça de Aquino, João Xavier de Araújo-Júnior, Edeildo da Silva-Júnior, Ednaldo Almeida Gomes, Antoniel Augustos Severo Gomes, José Pinto Siqueira-Júnior, Francisco Jaime Bezerra Mendonça Junior
One of the promising fields for improving the effectiveness of antimicrobial agents is their combination with efflux pump inhibitors (EPIs), which besides expanding the use of existing antibiotics. The goal of this research was to evaluate a series of aminoguanidine hydrazones (AGH's, 1-19) as antibacterial agents and NorA efflux pump inhibitors in Staphylococcus aureus strain SA-1199B. Molecular modeling and docking studies were also performed in order to explain at the molecular level the interactions of the compounds with the generated NorA efflux pump model...
December 2, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29181125/protective-effects-and-possible-mechanisms-of-ergothioneine-and-hispidin-against-methylglyoxal-induced-injuries-in-rat-pheochromocytoma-cells
#2
Tuzz-Ying Song, Nae-Cherng Yang, Chien-Lin Chen, Thuy Lan Vo Thi
Diabetic encephalopathy (DE) is often a complication in patients with Alzheimer's disease due to high blood sugar induced by diabetic mellitus. Ergothioneine (EGT) and hispidin (HIP) are antioxidants present in Phellinus linteus. Methylglyoxal (MGO), a toxic precursor of advanced glycated end products (AGEs), is responsible for protein glycation. We investigated whether a combination EGT and HIP (EGT + HIP) protects against MGO-induced neuronal cell damage. Rat pheochromocytoma (PC12) cells were preincubated with EGT (2 μM), HIP (2 μM), or EGT + HIP, then challenged with MGO under high-glucose condition (30 μM MGO + 30 mM glucose; GLU + MGO) for 24-96 h...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29174818/inhibition-of-advanced-glycation-endproduct-age-rescues-against-streptozotocin-induced-diabetic-cardiomyopathy-role-of-autophagy-and-er-stress
#3
Zhaohui Pei, Qinqin Deng, Sara A Babcock, Emily Y He, Jun Ren, Yingmei Zhang
Diabetes mellitus leads to oxidative stress and contractile dysfunction in the heart. Although several rationales have been speculated, the precise mechanism behind diabetic cardiomyopathy remains elusive. This study was designed to assess the role of inhibition of advanced glycation endproducts (AGE) in streptozotocin (STZ)-induced diabetic cardiac dysfunction. Cardiac contractile function was assessed in normal C57BL/6 and STZ (200mg/kg, single injection and maintained for 2 wks)-induced diabetic mice treated with or without the AGE inhibitor aminoguanidine (50mg/kg/d in drinking water) for 2 weeks using echocardiography and IonOptix MyoCam techniques...
November 22, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29170525/advanced-glycation-endproducts-link-inflammatory-cues-to-upregulation-of-galectin-1-in-diabetic-retinopathy
#4
Atsuhiro Kanda, Yoko Dong, Kousuke Noda, Wataru Saito, Susumu Ishida
Diabetic retinopathy (DR) is an inflammatory and progressive vaso-occlusive disease resulting in angiogenesis. Galectin-1 is a hypoxia-induced angiogenic factor associated with cancer and proliferative DR. Here we reveal a significant upregulation of galectin-1 in eyes of DR patients along with progression of clinical stages beginning from the pre-ischemic, inflammatory stage with diabetic macular edema, but not in eyes with non-diabetic retinal vascular occlusions. As for its regulatory mechanism unrelated to hypoxia but selective to DR, in vitro galectin-1/LGALS1 expression was shown to increase after application to Müller glial cells with interleukin (IL)-1β, which was induced in monocyte-derived macrophages and microglial cells via toll-like receptor (TLR) 4 signaling stimulated by advanced glycation endproducts (AGE)...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29168862/inhibition-of-advanced-glycation-endproducts-during-fish-sausage-preparation-by-transglutaminase-and-chitosan-oligosaccharides-induced-enzymatic-glycosylation
#5
Jing Wang, Long Zou, Fangzhou Yuan, Liangtao Lv, Shenglan Tian, Zhenxing Li, Hong Lin
Advanced glycation endproducts (AGEs) are the harmful products of non-enzymatic reactions in foods formed during the heating process. In order to reduce the content of AGEs in foods, the inhibitory effect of different proportions of transglutaminase (TGase) and chitosan oligosaccharides (COS) on the AGEs of seabream fish meat sausage was studied. The results indicated that the TGase/COS ratio of 1 : 1 could inhibit the formation of AGEs, showing especially a decreased N(ε)-carboxymethyl-lysine (CML) content and a twice higher inhibition rate (36...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29165729/polyphenols-from-euphorbia-pekinensis-inhibit-ages-formation-in-vitro-and-vessel-dilation-in-larval-zebrafish-in-vivo
#6
Ik-Soo Lee, Seung-Hyun Jung, Jin Sook Kim
To identify active compounds in the roots of Euphorbia pekinensis for treatment of diabetic complications, an active column fraction from a 70% EtOH extract of E. pekinensis root was purified by preparative reversed-phase high-performance liquid chromatography, leading to the isolation of a new ellagic acid derivative, 3,3'-di-O-methylellagic acid 4-O-(6"-O-galloyl)-β-D-galactopyranoside (1), along with three known compounds, geraniin (2), 3,3'-di-O-methylellagic acid 4-O-β-D-xylopyranoside (3), and ellagic acid 3,3'-dimethyl ether (4)...
November 17, 2017: Planta Medica
https://www.readbyqxmd.com/read/29152780/6-nitroazolo-1-5-a-pyrimidin-7-4h-ones-as-antidiabetic-agents
#7
Alexander A Spasov, Denis A Babkov, Valentina A Sysoeva, Roman A Litvinov, Darya D Shamshina, Evgeny N Ulomsky, Konstantin V Savateev, Viktor V Fedotov, Pavel A Slepukhin, Oleg N Chupakhin, Valery N Charushin, Vladimir L Rusinov
Prevention of the formation of advanced glycation end-products (AGEs) is a reliable approach to achieve control over hyperglycemia and the associated pathogenesis of diabetic vascular complications. In these terms, new synthetic approaches to 6-nitroazolo[1,5-a]pyrimidines have been developed on the basis of the promising antiglycation activity of their structural analogues, such as azolo[5,1-c][1,2,4]triazine-4(1H)-ones. A number of nitroazolopyrimidines were obtained by using nitration, chlorodeoxygenation, and amination reactions, and their antidiabetic properties were elucidated in vitro...
November 20, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29111523/the-synthesis-crystal-structure-and-thermal-properties-of-an-energetic-compound-the-hydrated-azanium-salt-of-3-6-bis-1h-1-2-3-4-tetrazol-5-yl-amino-1-2-4-5-tetrazine
#8
Qing Liu, Xiang Chen, Wenli Cao, Jin Yang, Wenhui Zhang, Yinghui Ren, Haixia Ma, Fengqi Zhao, Rongzu Hu
The energetic ionic salt bis(1-aminoguanidin-2-ium) 5,5'-[1,2,4,5-tetrazine-3,6-diylbis(azanediyl)]bis(1H-1,2,3,4-tetrazol-1-ide) dihydrate, 2CH7N4(+)·C4H2N14(2-)·2H2O, (I), with a high nitrogen content, has been synthesized and examined by elemental analysis, Fourier transform IR spectrometry, (1)H NMR spectroscopy and single-crystal X-ray crystallography. Compound (I) crystallizes in the monoclinic space group P21/c with two water molecules. However, the water molecules are disordered about an inversion centre and were modelled as half-occupancy molecules in the structure...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29109744/selective-nitric-oxide-synthase-inhibitor-promotes-bone-healing
#9
Ali Reza Farhad, Sayed Mohammad Razavi, Ali Reza Rozati, Neda Shekarchizade, Maziar Manshaei
Background: Nitric oxide (NO) has many functions in wound healing and bone metabolism. This study sought to assess the local effect of aminoguanidine (AG), a selective inducible NO synthase (iNOS) inhibitor, on the rate of bone healing. Materials and Methods: This experimental interventional study was conducted on 36 rats, which were randomly divided into three groups of control, placebo, and AG. Bone defects measuring 5 mm × 5 mm were created in the femur. In control group, bone defects remained empty...
September 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29108256/sphingosine-kinase-1-mediates-ages-induced-fibronectin-upregulation-in-diabetic-nephropathy
#10
Cheng Chen, Wenyan Gong, Changzheng Li, Fengxiao Xiong, Shaogui Wang, Junying Huang, Yu Wang, Zhiquan Chen, Qiuhong Chen, Peiqing Liu, Tian Lan, Heqing Huang
Activation of sphingosine kinase 1 (SphK1) signaling pathway mediates fibronectin (FN) upregulation in glomerular mesangial cells (GMCs) under high glucose (HG) condition. However, the roles of SphK1 in advanced glycation end products (AGEs)-induced DN have not been elucidated. Here we show that AGEs upregulated FN and SphK1 and SphK1 activity. Inhibition of SphK1 signaling attenuated AGEs-induced FN synthesis in GMCs. Inhibition of AGE receptor (RAGE) signaling reduced the upregulation of FN and SphK1 and SphK1 activity in GMCs induced by AGEs...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29066484/aminoguanidine-ag-induces-induced-both-pro-and-antioxidant-effect-in-ar42j-cells-a-rat-pancreatic-tumor-cell-line
#11
Parimal Chowdhury
Aminoguanidine (AG), a diamine oxidase and a nitric oxide synthase inhibitor, was used in diabetes, thyroid follicular carcinoma, hepatocellular carcinoma, pancreatic cancer xenografts and in breast cancer research. The effects of AG on these pathologic conditions may be related to its regulatory effects on cell proliferation, angiogenesis, and expression of antioxidant enzymes. However, its role as pro and/or anti-oxidant affecting signaling and function in pancreatic tumor cell lines has not been studied...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29035879/advanced-glycation-end-products-impair-ca2-mobilization-and-sensitization-in-colonic-smooth-muscle-cells-via-the-camp-pka-pathway
#12
Ting Yu, Yun Wang, Dong Qian, Xiaomeng Sun, Yurong Tang, Xiaoxue Shen, Lin Lin
BACKGROUND/AIMS: Excessive production of advanced glycation end products (AGEs) has been implicated in diabetes-related complications. This study aimed to investigate the mechanism by which AGEs potentially contribute to diabetes-associated colonic dysmotility. METHODS: Control and streptozotocin (STZ)-induced diabetic groups were treated with aminoguanidine (AG). The colonic transit time and contractility of circular muscle strips was measured. ELISA, immunohistochemistry and western blotting were used to measure Nε-carboxymethyl-lysine (CML) levels...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28988949/structure-of-the-guanidine-iii-riboswitch
#13
Lin Huang, Jia Wang, Timothy J Wilson, David M J Lilley
Riboswitches are structural elements found in mRNA molecules that couple small-molecule binding to regulation of gene expression, usually by controlling transcription or translation. We have determined high-resolution crystal structures of the ykkC guanidine III riboswitch from Thermobifida fusca. The riboswitch forms a classic H-type pseudoknot that includes a triple helix that is continuous with a central core of conserved nucleotides. These form a left-handed helical ramp of inter-nucleotide interactions, generating the guanidinium cation binding site...
November 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28988841/adsorption-of-cu-ii-cd-ii-hg-ii-pb-ii-and-zn-ii-from-aqueous-single-metal-solutions-by-guanyl-modified-cellulose
#14
I M Kenawy, M A H Hafez, M A Ismail, M A Hashem
A novel chemically guanyl-modified cellulose (Gu-MC) - material has been synthesized for the adsorption of Cu(2+), Cd(2+), Hg(2+), Pb(2+) and Zn(2+) metal ions from aqueous solution. Cellulose was pretreated with periodate prior to its condensation with aminoguanidine for the formation of cellulose aldehyde-guanyl Schiff's. The synthesized material was characterized by Fourier transform infrared spectra (FTIR), elemental analysis, scanning electron microscope (SEM) and thermogravimetric analysis (TGA). Moreover, the effect of contact time, pH, adsorbent dosage, interfering ions and initial concentration of metal ions on the adsorption capacity were investigated...
October 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28987270/involvement-of-nitrergic-system-in-anticonvulsant-effect-of-zolpidem-in-lithium-pilocarpine-induced-status-epilepticus-evaluation-of-inos-and-cox-2-genes-expression
#15
Seyyed Majid Eslami, Maryam Ghasemi, Taraneh Bahremand, Majid Momeny, Mahdi Gholami, Mohammad Sharifzadeh, Ahmad Reza Dehpour
This study aims to investigate the role of zolpidem in lithium-pilocarpine induced status epilepticus (SE) and probable mechanisms involved in seizure threshold alteration. In the present study, lithium chloride (127mg/kg) was administered 20h prior to pilocarpine (60mg/kg) to induce SE in adult male Wistar rats. Different doses of zolpidem (0.1, 1, 2, 5, 10mg/kg) were injected 30min before pilocarpine administration. Furthermore, to find out whether nitric oxide (NO) plays a role in the observed effect, L-arginine and L-NAME were injected 15min before zolpidem...
October 4, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28947331/ketamine-and-aminoguanidine-differentially-affect-bdnf-and-mtor-gene-expression-in-the-prefrontal-cortex-of-adult-male-rats
#16
Vitor Silva Pereira, Betina Elfving, Sâmia R L Joca, Gregers Wegener
The rapid and sustained antidepressant properties of ketamine provide evidence of the importance of the glutamatergic system in the neurobiology of depression. The antidepressant-like effects of ketamine are dependent on brain-derived neurotrophic factor (BDNF) and mammalian target of rapamycin (mTOR) in limbic brain areas. The nitrergic system is closely related to the glutamatergic system and generates antidepressant-like effects when blocked. The aim of this study was to investigate whether the behavioural effects induced by the inhibition of nitric oxide (NO) synthesis by aminoguanidine or N-methyl-D-aspartate (NMDA) receptor blockade by ketamine would affect the gene expression of Bdnf and Mtor in the ventromedial prefrontal cortex in rats...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28946226/accumulating-pathways-of-%C3%AE-aminobutyric-acid-during-anaerobic-and-aerobic-sequential-incubations-in-fresh-tea-leaves
#17
Qin Yan Wu, Sheng Zhou Ma, Wen Wen Zhang, Ke Bing Yao, Lu Chen, Fei Zhao, Yi Qing Zhuang
The roles of the γ-aminobutyric acid (GABA) shunt and polyamine (PA) degradation pathway on GABA accumulation were investigated in fresh tea leaves under anaerobic and aerobic sequential incubations. The GABA accumulation was mainly completed in the first anaerobic incubation through the interaction of the GABA shunt with the PA degradation pathway. When treated with aminoguanidine, the diamine oxidase and polyamine oxidase activities were almost completely inhibited, and the GABA contents decreased by 40...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28942508/role-of-inducible-nitric-oxide-synthase-in-myocardial-ischemia-reperfusion-injury-in-sleep-deprived-rats
#18
Sajad Jeddi, Asghar Ghasemi, Alireza Asgari, Amir Nezami-Asl
INTRODUCTION: REM sleep deprivation (SD) decreases tolerance of the rat heart to ischemia-reperfusion (IR) injury; the underlying mechanisms, however, are unknown. This study aimed at determining whether changes in iNOS, Bax, and Bcl-2 gene expression are involved in this detrimental effect. METHOD: SD was induced by flowerpot technique for a period of 4 days. This method is simple and able to induce sleep fragmentation which occurs as one of the sleep disorder symptoms in clinical conditions...
September 23, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28929917/mercurius-solubilis-attenuates-scopolamine-induced-memory-deficits-and-enhances-the-motor-coordination-in-mice
#19
Simranjeet Kaur, Anudeep Kaur, Gurjit Singh, Rajbir Bhatti
AIM: The present study was designed to investigate the effect of mercurius solubilis (merc sol) on scopolamine induced memory deficits and motor coordination in mice. MATERIALS AND METHODS: Three different formulations of merc sol (30X, 200M, 1M) were screened for their in vitro antioxidant potential through DPPH (2, 2-diphenyl-1-picrylhydrazyl) and nitric oxide scavenging activity using response surface methodology. Memory impairment was induced by the administration of scopolamine (1mg/kg i...
October 16, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28926063/methylglyoxal-attenuates-insulin-signaling-and-downregulates-the-enzymes-involved-in-cholesterol-biosynthesis
#20
Arati B Deshmukh, Shakuntala Bai, Aarthy T, Rubina S Kazi, Reema Banarjee, Rajeshwari Rathore, Vijayakumar Mv, Thulasiram Hv, Manoj Kumar Bhat, Kulkarni Mj
Methylglyoxal (MG) is a highly reactive dicarbonyl known to be elevated under the hyperglycemic conditions of diabetes and is implicated in the development of diabetic complications. Therefore, the current study investigates the role of MG in exacerbating insulin resistance at the insulin signaling level, as well as its effect on the global proteomic level. By using insulin sensitive rat muscle cells (L6) and Chinese hamster ovary (CHO) cells stably expressing the insulin receptor (IR) and a glucose transporter fused with green fluorescent protein (GLUT4-GFP), we have observed that MG impairs insulin signaling, inhibits GLUT4 translocation and reduces glucose uptake...
October 24, 2017: Molecular BioSystems
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