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https://www.readbyqxmd.com/read/27919702/design-of-pvp-va-s-630-based-tadalafil-solid-dispersion-to-enhance-the-dissolution-rate
#1
Jin-Seok Choi, Jeong-Sook Park
Tadalafil (TDF) is a Biopharmaceutics Classification System (BCS) class II drug; the efficacy thereof is critically limited by inherent poor water solubility. Solid dispersion (SD) techniques are widely used to improve the bioavailability of drugs that are poorly water-soluble. Herein, we used an SD technique to improve the solubility and in vitro dissolution rate of TDF; a solvent evaporation method was applied involving the use of hydrophilic carriers (PVP/VA S-630) and assistants (malic acid or meglumine)...
December 2, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27892943/temperature-responses-of-rubisco-from-paniceae-grasses-provide-opportunities-for-improving-c3-photosynthesis
#2
Robert E Sharwood, Oula Ghannoum, Maxim V Kapralov, Laura H Gunn, Spencer M Whitney
Enhancing the catalytic properties of the CO2-fixing enzyme Rubisco is a target for improving agricultural crop productivity. Here, we reveal extensive diversity in the kinetic response between 10 and 37 °C by Rubisco from C3 and C4 species within the grass tribe Paniceae. The CO2 fixation rate (kcatc) for Rubisco from the C4 grasses with nicotinamide adenine dinucleotide (NAD) phosphate malic enzyme (NADP-ME) and phosphoenolpyruvate carboxykinase (PCK) photosynthetic pathways was twofold greater than the kcatc of Rubisco from NAD-ME species across all temperatures...
November 28, 2016: Nature Plants
https://www.readbyqxmd.com/read/27889148/surface-attachment-of-active-antimicrobial-coatings-onto-conventional-plastic-based-laminates-and-performance-assessment-of-these-materials-on-the-storage-life-of-vacuum-packaged-beef-sub-primals
#3
David Clarke, Andrey A Tyuftin, Malco C Cruz-Romero, Declan Bolton, Seamus Fanning, Shashi K Pankaj, Carmen Bueno-Ferrer, Patrick J Cullen, Joe P Kerry
Two antimicrobial coatings, namely Sodium octanoate and Auranta FV (a commercial antimicrobial composed of bioflavonoids, citric, malic, lactic, and caprylic acids) were used. These two antimicrobials were surface coated onto the inner polyethylene layer of cold plasma treated polyamide films using beef gelatin as a carrier and coating polymer. This packaging material was then used to vacuum pack beef sub-primal cuts and stored at 4 °C. A control was prepared using the non-coated commercial laminate and the same vacuum packaged sub-primal beef cuts...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27886543/interactions-among-triphenyltin-degradation-phospholipid-synthesis-and-membrane-characteristics-of-bacillus-thuringiensis-in-the-presence-of-d-malic-acid
#4
Linlin Wang, Wenying Yi, Jinshao Ye, Huaming Qin, Yan Long, Meng Yang, Qusheng Li
Degradation pathway and surface biosorption of triphenyltin (TPT) by effective microbes have been investigated in the past. However, unclear interactions among membrane components and TPT binding and transport are still obstacles to understanding TPT biotransformation. To reveal the mechanism involved, the phospholipid expression, membrane potential, cellular mechanism and molecular dynamics between TPT and fatty acids (FAs) during the TPT degradation process in the presence of d-malic acid (DMA) were studied...
November 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/27880890/potential-antidepressant-and-resilience-mechanism-revealed-by-metabolomic-study-on-peripheral-blood-mononuclear-cells-of-stress-resilient-rats
#5
Juan Li, Shu-Xiao Zhang, Wei Wang, Ke Cheng, Hua Guo, Cheng-Long Rao, De-Yu Yang, Yong He, De-Zhi Zou, Yu Han, Li-Bo Zhao, Peng-Fei Li, Peng Xie
Resilience is an active coping response to stress, which plays a very important role in major depressive disorder study. The molecular mechanisms underlying such resilience are poorly understood. Peripheral blood mononuclear cells (PBMCs) were promising objects in unveiling the underlying pathogenesis of resilience. Hereby we carried out successive study on PBMCs metabolomics in resilient rats of chronic unpredictable mild stress (CUMS) model. A gas chromatography-mass spectrometry (GC-MS) metabolomic approach coupled with principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) was used to detect differential metabolites in PBMCs of resilient rats...
November 21, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27875779/novel-pyrimidine-2-4-dione-1-2-3-triazole-and-furo-2-3-d-pyrimidine-2-one-1-2-3-triazole-hybrids-as-potential-anti-cancer-agents-synthesis-computational-and-x-ray-analysis-and-biological-evaluation
#6
Tomislav Gregorić, Mirela Sedić, Petra Grbčić, Andrea Tomljenović Paravić, Sandra Kraljević Pavelić, Mario Cetina, Robert Vianello, Silvana Raić-Malić
Regioselective 1,4-disubstituted 1,2,3-triazole tethered pyrimidine-2,4-dione derivatives (5-23) were successfully prepared by the copper(I)-catalyzed click chemistry. While known palladium/copper-cocatalyzed method based on Sonogashira cross-coupling followed by the intramolecular 5-endo-dig ring closure generated novel 6-alkylfuro[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids (24b-37b), a small library of their 5-alkylethynyl analogs (24a-37a) was synthesized and described for the first time by tandem terminal alkyne dimerization and subsequent 5-endo-trig cyclization, which was additionally corroborated with computational and X-ray crystal structure analyses...
November 14, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27874251/simultaneous-analysis-of-ten-low-molecular-mass-organic-acids-in-the-tricarboxylic-acid-cycle-and-photorespiration-pathway-in-thalassiosira-pseudonana-at-different-growth-stages
#7
Mengwei Ye, Lijing Zhang, Panpan Xu, Runtao Zhang, Jilin Xu, Xiaokai Wu, Juanjuan Chen, Chengxu Zhou, Xiaojun Yan
A method using high-performance liquid chromatography coupled with tandem mass spectrometry was developed for simultaneous determination of organic acids in microalgae. o-Benzylhydroxylamine was used to derivatize the analytes, and stable isotope-labeled compounds were used as internal standards for precise quantification. The proposed method was evaluated in terms of linearity, recovery, matrix effect, sensitivity, and precision. Linear calibration curves with correlation coefficients of >0.99 were obtained over the concentration range of 0...
November 22, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27871369/co2-reduction-and-organic-compounds-production-by-photosynthetic-bacteria-with-surface-displayed-carbonic-anhydrase-and-inducible-expression-of-phosphoenolpyruvate-carboxylase
#8
Ju-Yong Park, Yang-Hoon Kim, Jiho Min
In Rhodobacter sphaeroides, carbonic anhydrase (CA; EC 4.2.1.1) is a zinc-containing metalloenzyme that catalyzes the reversible hydration of CO2 to HCO3(-) while phosphoenolpyruvate carboxylase (PEPC; 4.1.1.31), an enzyme involved in the carbon metabolism that catalyzed the fixation of CO2 to PEP, is a key factor for biological fixation of CO2 and enhances the production of organic compounds. In this study, the recombinant R. sphaeroides with highly-expressed CA was developed based on a surface displayed system of CA (pJY-OmpCA) on the outer membrane of R...
January 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27855909/nutritional-and-chemical-characterization-of-edible-petals-and-corresponding-infusions-valorization-as-new-food-ingredients
#9
Tânia C S P Pires, Maria Inês Dias, Lillian Barros, Isabel C F R Ferreira
Edible flowers provide new colours, textures and vibrancy to any dish, and apart from the "glam" factor, they can constitute new sources of bioactive compounds. In the present work, the edible petals and infusions of dahlia, rose, calendula and centaurea, were characterized regarding their nutritional value and composition in terms of hydrophilic and lipophilic compounds. Carbohydrates were the most abundant macronutrients, followed by proteins and ash. Fructose, glucose and sucrose were identified in all the petals and infusions...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27825532/enhanced-recovery-of-valuable-metals-from-spent-lithium-ion-batteries-through-optimization-of-organic-acids-produced-by-aspergillus-niger
#10
Nazanin Bahaloo-Horeh, Seyyed Mohammad Mousavi
In the present study, spent medium bioleaching method was performed using organic acids produced by Aspergillus niger to dissolve Ni, Co, Mn, Li, Cu and Al from spent lithium-ion batteries (LIBs). Response surface methodology was used to investigate the effects and interactions between the effective factors of sucrose concentration, initial pH, and inoculum size to optimize organic acid production. Maximum citric acid, malic acid, and gluconic acid concentrations of 26,478, 1832.53 and 8433.76ppm, respectively, and a minimum oxalic acid concentration of 305...
November 4, 2016: Waste Management
https://www.readbyqxmd.com/read/27825490/phosphate-dissolving-fungi-mechanism-and-application-in-alleviation-of-salt-stress-in-wheat
#11
Sunita Gaind
The present investigation reveals the solubilization efficiency of tri-calcium phosphate (TCP), Udaipur rock phosphate (URP), aluminium phosphate (AP) and ferric phosphate (FP) by Aspergillus niger (ITCC 6719) and Trichoderma harzianum (ITCC 6721) as function of carbon concentrations. Increasing glucose concentration from 1 to 7% in the growth medium, though improved the phosphorus (P) solubilization significantly but each fungal strain preferred different optimum carbon concentrations for mediating solubilization of different P sources...
December 2016: Microbiological Research
https://www.readbyqxmd.com/read/27825399/fluctuations-in-metabolite-content-in-the-liver-of-magnesium-deficient-rats
#12
Mei Shigematsu, Ryosuke Nakagawa, Shozo Tomonaga, Masayuki Funaba, Tohru Matsui
Mg deficiency induces various metabolic disturbances including glucose metabolism in the liver. However, no comprehensive information is currently available on the metabolic pathways affected by Mg deficiency. The present study examined metabolite content in the liver of Mg-deficient rats using a metabolomic analysis. In this study, 4-week-old, male Sprague-Dawley rats were fed a control diet or a Mg-deficient diet for 8 weeks. The metabolomic analysis identified 105 metabolites in the liver, and significant differences were observed in the hepatic contents for thirty-three metabolites between the two groups...
November 9, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27822898/optimization-of-air-blast-drying-process-for-manufacturing-saccharomyces-cerevisiae-and-non-saccharomyces-yeast-as-industrial-wine-starters
#13
Sae-Byuk Lee, Won-Seok Choi, Hyun-Jung Jo, Soo-Hwan Yeo, Heui-Dong Park
Wine yeast (Saccharomyces cerevisiae D8) and non-Saccharomyces wine yeasts (Hanseniaspora uvarum S6 and Issatchenkia orientalis KMBL5774) were studied using air-blast drying instead of the conventional drying methods (such as freeze and spray drying). Skim milk-a widely used protective agent-was used and in all strains, the highest viabilities following air-blast drying were obtained using 10% skim milk. Four excipients (wheat flour, nuruk, artichoke powder, and lactomil) were evaluated as protective agents for yeast strains during air-blast drying...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27810543/biotic-ligand-model-explains-the-effects-of-competition-but-not-complexation-for-sm-biouptake-by-chlamydomonas-reinhardtii
#14
Qiao-Guo Tan, Guang Yang, Kevin J Wilkinson
The applicability of the biotic ligand model (BLM) was tested with respect to the biouptake of the lanthanide Sm by the freshwater green alga, Chlamydomonas reinhardtii. In the absence of organic ligands, Sm uptake was well described by the Michaelis-Menten equation, consistent with the BLM assumption of single transporter, with the maximum influx rate (Jmax) of 1.5 × 10(-14) mol cm(-2) s(-1) and a binding constant (KSm) of 10(7.0) M(-1). The addition of organic ligands (i.e., malic acid, diglycolic acid and citric acid) decreased Sm influx rates, however, the decreases were much less than that predicted by the BLM, possibly due to the direct contribution of the Sm complexes...
October 28, 2016: Chemosphere
https://www.readbyqxmd.com/read/27805020/relative-abundance-of-chemical-forms-of-cu-ii-and-cd-ii-on-soybean-roots-as-influenced-by-ph-cations-and-organic-acids
#15
Qin Zhou, Zhao-Dong Liu, Yuan Liu, Jun Jiang, Ren-Kou Xu
Little information is available on chemical forms of heavy metals on integrate plant roots. KNO3 (1 M), 0.05M EDTA at pH6 and 0.01 M HCl were used sequentially to extract the exchangeable, complexed and precipitated forms of Cu(II) and Cd(II) from soybean roots and then to investigate chemical form distribution of Cu(II) and Cd(II) on soybean roots. Cu(II) and Cd(II) adsorbed on soybean roots were mainly exchangeable form, followed by complexed form, while their precipitated forms were very low under acidic conditions...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27800716/pretreatment-of-mqa-a-caffeoylquinic-acid-derivative-compound-protects-against-h2o2-induced-oxidative-stress-in-sh-sy5y-cells
#16
Xing Tian, Lingyue Gao, Li An, Xiaowen Jiang, Junpeng Bai, Jian Huang, Weihong Meng, Qingchun Zhao
OBJECTIVES: Compound MQA (1,5-O-dicaffeoyl-3-O-[4-malic acid methyl ester]-quinic acid) is a natural caffeoylquinic acid derivative isolated from Arctium lappa L. roots. This study aims to explore the neuroprotective effects of MQA against hydrogen peroxide (H2O2)-induced oxidative stress in SH-SY5Y neuroblastoma cells. METHODS: The SH-SY5Y cells were divided into four groups, including control, 20 μM MQA, 200 μM H2O2, 200 μM H2O2 + 20 μM MQA groups. The effects of MQA on H2O2-induced cell death were measured by MTT and LDH assays...
November 1, 2016: Neurological Research
https://www.readbyqxmd.com/read/27798266/focally-perfused-succinate-potentiates-brain-metabolism-in-head-injury-patients
#17
Ibrahim Jalloh, Adel Helmy, Duncan J Howe, Richard J Shannon, Peter Grice, Andrew Mason, Clare N Gallagher, Matthew G Stovell, Susan van der Heide, Michael P Murphy, John D Pickard, David K Menon, T Adrian Carpenter, Peter J Hutchinson, Keri Lh Carpenter
Following traumatic brain injury, complex cerebral energy perturbations occur. Correlating with unfavourable outcome, high brain extracellular lactate/pyruvate ratio suggests hypoxic metabolism and/or mitochondrial dysfunction. We investigated whether focal administration of succinate, a tricarboxylic acid cycle intermediate interacting directly with the mitochondrial electron transport chain, could improve cerebral metabolism. Microdialysis perfused disodium 2,3-(13)C2 succinate (12 mmol/L) for 24 h into nine sedated traumatic brain injury patients' brains, with simultaneous microdialysate collection for ISCUS analysis of energy metabolism biomarkers (nine patients) and nuclear magnetic resonance of (13)C-labelled metabolites (six patients)...
October 17, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27792926/polymalic-acid-fermentation-by-aureobasidium-pullulans-for-malic-acid-production-from-soybean-hull-and-soy-molasses-fermentation-kinetics-and-economic-analysis
#18
Chi Cheng, Yipin Zhou, Meng Lin, Peilian Wei, Shang-Tian Yang
Polymalic acid (PMA) production by Aureobasidium pullulans ZX-10 from soybean hull hydrolysate supplemented with corn steep liquor (CSL) gave a malic acid yield of ∼0.4g/g at a productivity of ∼0.5g/L·h. ZX-10 can also ferment soy molasses, converting all carbohydrates including the raffinose family oligosaccharides to PMA, giving a high titer (71.9g/L) and yield (0.69g/g) at a productivity of 0.29g/L·h in fed-batch fermentation under nitrogen limitation. A higher productivity of 0.64g/L·h was obtained in repeated batch fermentation with cell recycle and CSL supplementation...
October 18, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27782384/use-of-ion-chromatography-mass-spectrometry-for-targeted-metabolite-profiling-of-polar-organic-acids
#19
Chris Petucci, Andrew Zelenin, Jeffrey A Culver, Meghan Gabriel, Ken Kirkbride, Terri T Christison, Stephen J Gardell
Organic acids (OAs) serve as metabolites that play pivotal roles in a host of different metabolic and regulatory pathways. The polar nature of many OAs poses a challenge to their measurement using widely-practiced analytical methods. In this study, a targeted metabolomics method was developed using ion chromatography/triple quadrupole mass spectrometry (IC/MS) to quantitate 28 polar OAs with limits of quantitation ranging from 0.25-50 µM. The inter-day assay precisions ranged from 1-19%, with accuracies ranging from 82 to 115%...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27781395/the-effects-of-temperature-and-mobile-phase-on-the-retention-of-aliphatic-carboxylic-acids-in-hydrophilic-interaction-chromatography-on-zwitterionic-stationary-phases
#20
Iveta Boháčová, Radoslav Halko, Pavel Jandera
The influence of the mobile phase and temperature, on the retention behavior of seven aliphatic acids (pyruvic, gluconic, 2-oxoglutaric, tartaric, malic, oxalic and citric acid) in hydrophilic interaction liquid chromatography on zwitterionic stationary phases with sulfobetaine and phosphorylcholine ligands is investigated. In agreement with the van't Hoff model, most acids show linear ln k versus 1/T plots. However, the retention of structurally symmetrical oxalic and tartaric dicarboxylic acids is almost independent of temperature, or slightly increases at rising temperature...
October 25, 2016: Journal of Separation Science
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