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malic acid

Alberto Tejero Rioseras, Kapil Dev Singh, Nora Nowak, Martin T Gaugg, Tobias Bruderer, Renato Zenobi, Pablo M-L Sinues
The tricarboxylic acid (TCA) cycle is one of the most important metabolic pathway for cellular respiration in aerobic organisms. It provides and collects intermediates for many other interconnecting pathways and acts as a hub connecting metabolism of carbohydrates, fatty acids, and amino acids. Alteration in intracellular levels of its intermediates has been linked with a wide range of illnesses ranging from cancer to cellular necrosis or liver cirrhosis. Therefore, there exists an intrinsic interest in monitoring such metabolites...
May 16, 2018: Analytical Chemistry
Antoine Bigard, Dargie T Berhe, Eleonora Maoddi, Yannick Sire, Jean-Michel Boursiquot, Hernan Ojeda, Jean-Pierre Péros, Agnès Doligez, Charles Romieu, Laurent Torregrosa
The wine industry is facing critical issues due to climate changes since production is established on very tight Genotype × Environment interaction bases. While, some cultivation practices may reduce adverse effects of abiotic stresses on the vines, e.g., the use of irrigation to mitigate drought, the deleterious impacts of warming on fruit development are difficult to manage. Elevated temperature alters grapevine fruit growth and composition, with a critical increase of the sugars/organic acids ratio. Select grapes with improved metabolite balances to offset high temperature effects is a valuable option to sustain viticulture...
2018: Frontiers in Plant Science
Ravichandiran Kumar, Brinda Chandar, Madasamy Parani
Background & objectives: New Delhi metallo-β-lactamase 1 (NDM-1) cleaves the beta-lactam ring, and confers bacterial resistance against most of the beta-lactam antibiotics, except tigecycline and colistin. Among these two antibiotics, colistin is considered toxic, and therefore, its clinical use and dosage need cautious approach. In the present study, six organic acids were screened individually and in combination of two acids for their effectiveness against NDM-1 Escherichia coli and a combination of colistin and oxalic or succinic acid was tested to find out the potential of combination therapy for reducing the dose of toxic colistin...
January 2018: Indian Journal of Medical Research
Jinbin Wang, Wen Li, Zhengpeng Li, Wenhui Wu, Xueming Tang
To identify the characteristic taste components of the common cultivated mushroom (brown; Portobello), Agaricus bisporus, taste components in the stipe and pileus of Portobello mushroom harvested at different growth stages were extracted and identified, and principal component analysis (PCA) and taste active value (TAV) were used to reveal the characteristic taste components during the each of the growth stages of Portobello mushroom. In the stipe and pileus, 20 and 14 different principal taste components were identified, respectively, and they were considered as the principal taste components of Portobello mushroom fruit bodies, which included most amino acids and 5'-nucleotides...
May 10, 2018: Journal of Food Science
Zi Juan Liu, Zong Peng Yang, Ping Li, Yu Zheng Zong, Qi Dong, Xing Yu Hao
We used an OTC (open top chamber) system to study the effects of elevated CO2 concentration (atmospheric CO2 concentration + 200 #x03BC;mol·mol-1 ) on the growth and photosynthetic physiology of Hylotelephium erythrostictum. Elevated CO2 concentration decreased the leaf stomatal density of the upper and lower epidermis of H. erythrostictum by 16.1% and 16.7%, respectively. Elevated CO2 concentration increased the vascular bundle in leaves and the cell volume near the upper epidermis. Elevated CO2 concentration significantly increased the photosynthetic pigments content, net photosynthetic rate, stomatal conductance and transpiration rate of H...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Bin Lian, Jinjun Xia, Xun Yang, Chanjuan Zhou, Xue Gong, Siwen Gui, Qiang Mao, Ling Wang, Pengfei Li, Cheng Huang, Xunzhong Qi, Peng Xie
In the present study, we used a gas chromatography-mass spectrometry-based metabolomics method to evaluate the effects of ketamine on mice hippocampi. Multivariate statistical analysis and ingenuity pathway analysis were then used to identify and explore the potential mechanisms and biofunction of ketamine. Compared with the control (CON) group, 14 differential metabolites that involved amino acid metabolism, energy metabolism, and oxidative stress metabolism were identified. After combination with 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX) administration, six of the 14 metabolites remained significantly differentially expressed between the ketamine (KET) and KET+NBQX groups, including glycine, alanine, glutamine, aspartic acid, myoinositol, and ascorbate, whereas no difference was found in the levels of the other eight metabolites between the KET and KET+NBQX groups, including phosphate, 4-aminobutyric acid, urea, creatine, L-malic acid, galactinol, inosine, and aminomalonic...
May 8, 2018: Neuroreport
Idolo Ifie, Beatrice E Ifie, Dorcas O Ibitoye, Lisa J Marshall, Gary Williamson
Seasonal variations in crops can alter the profile and amount of constituent compounds and consequentially any biological activity. Differences in phytochemical profile, total phenolic content and inhibitory activity on α-glucosidase (maltase) of Hibiscus sabdariffa calyces grown in South Western Nigeria were determined over wet and dry seasons. The phenolic profile, organic acids and sugars were analysed using HPLC, while inhibition of rat intestinal maltase was measured enzymically. There was a significant increase (1...
September 30, 2018: Food Chemistry
Elbaleeq A Gubartallah, Ahmad Makahleh, Joselito P Quirino, Bahruddin Saad
A rapid and green analytical method based on capillary electrophoresis with capacitively coupled contactless conductivity detection (C⁴D) for the determination of eight environmental pollutants, the biogenic amines (putrescine, cadaverine, spermidine, spermine, tyramine, 2-phenylamine, histamine and tryptamine), is described. The separation was achieved under normal polarity mode at 24 °C and 25 kV with a hydrodynamic injection (50 mbar for 5 s) and using a bare fused-silica capillary (95 cm length × 50 µm i...
May 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Bárbara Mercedes Bravo-Ferrada, Sónia Gonçalves, Liliana Semorile, Nuno C Santos, Natalia Brizuela, E Elizabeth Tymczyszyn, Axel Hollmann
The aim of the present study was to evaluate the effects of freeze-drying in the presence of trehalose as a cryoprotectant, followed by incubation in synthetic wine, on surface damage, viability and l-malic acid consumption of the oenological strain Oenococcus oeni UNQOe 73.2. After freeze-drying, no significant differences were observed in the number of viable cells (for both acclimated and non-acclimated cultures) respect to the fresh culture. In contrast, loss of viability was observed after wine incubation for 24 h, being acclimated freeze-dried cells the best conditions for this...
April 28, 2018: Cryobiology
Xiaopeng Mu, Pengfei Wang, Junjie Du, Yu Gary Gao, Jiancheng Zhang
Cerasus humilis (Bge.) Sok and Cerasus glandulosa (Thunb.) Lois are economically important fruit-producing shrubs. Although these two species have similar looking fruits, their fruit organic acid contents differ drastically. In this study, we focused on comparing the organic acid content, activity of enzymes gene expression involved in organic acid metabolism in both C. humilis and C. glandulosa fruits. To investigate the differences of organic acid metabolism in fruits of these two species, a comparative transcriptome analysis was performed...
2018: PloS One
Meng Li, Jia Yue Chen, Jing Fang Xie, Jia Li Lyu, Shao Long Gao, Rui Qing Liu
To investigate the influences of sewage and cadmium combined stress on maize seedling metabolites, we took GC-MS metabonomics technology to analyze the metabolite species, content and metabolic pathways. A total of 50 kinds of metabolites were identified. Under single stress of Cd, the malic acid content in maize seedling decreased, the citric acid content increased significantly, and the tricarboxylic acid cycle was relatively stable. Under the combined stress, both malic acid and citric acid contents increased significantly, and the tricarboxylic acid cycle was inhibited...
November 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Wei Qin Yin, Hao Qi Jing, Ya Bo Wang, Si Yu Wei, Yue Sun, Sheng Sen Wang, Xuai Zhi Wang
The elevated concentration of tropospheric ozone (O3 ) is an important global climate change driver, with adverse impacts on soil ecological environment and crop growth. In this study, a pot experiment was carried out in an open top chamber (OTC), to investigate the effects of elevated ozone concentration on soil enzyme activities (catalase, polyphenol oxidase, dehydrogenase and invertase), organic acids contents (oxalic acid, citric acid and malic acid) at different growth stages (tillering, jointing, heading and ripening stages) of wheat, and combined with the rhizospheric soil physicochemical properties and plant root characteristics to analyze the underlying reasons...
February 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Makoto Imura, Ryo Iwakiri, Takeshi Bamba, Eiichiro Fukusaki
The budding yeast Saccharomyces cerevisiae is an important microorganism for fermentation and the food industry. However, during production, S. cerevisiae commonly uses the ethanol fermentation pathway for glucose utilization if excess sugar is present, even in the presence of sufficient oxygen levels. This aerobic ethanol fermentation, referred to as "the Crabtree effect" is one of the most significant reasons for low cell yield. To weaken the Crabtree effect in fed-batch and continuous culture, sugar flow should be limited...
April 20, 2018: Journal of Bioscience and Bioengineering
Alonzo A Gabriel, Jeffrey M Ostonal, Jannelle O Cristobal, Gladess A Pagal, John Vincent E Armada
This study determined the inactivation kinetic parameters of selected pathogens in heat, ultraviolet-C and combined heat-UV-C treated coconut liquid endosperm. Separate cocktails of Escherichia coli O157:H7, Salmonella enterica serovars, and Listeria monocytogenes strains were inoculated into coconut liquid endosperm (pH 5.15, TSS 4.4o Bx, TA 0.062% malic acid, extinction coefficient (ε) at 254 nm of 0.0154 cm-1 ) for inactivation studies. Result showed that all organisms generally exhibited a log-linear heat inactivation behavior (R2 0...
April 14, 2018: International Journal of Food Microbiology
Hyo-Nam Song, So-Ae Ji, Hye-Rim Park, Ho-Hyoen Kim, Christer Hogstrand
The attractive purple color of blueberries ( Vaccinium spp.) is unstable and susceptible to degradation during food processing and storage. The effects of various factors on the color stability of fresh blueberry juice were investigated. Total soluble solid content, pH, and total anthocyanin content were measured. Heating at 30°C and 60°C for 300 min did not influence the color stability, but heating at 100°C drastically decreased it by 33.0%. Sugars decreased color in a concentration-dependent manner. However, glucose and galactose had significantly protective effects on the color disruption than fructose, maltose, and sucrose...
March 2018: Preventive Nutrition and Food Science
Fariborz Faraji, Rabeeh Golmohammadzadeh, Fereshteh Rashchi, Navid Alimardani
In this study, Aspergillus niger (A. niger) as an environmentally friendly agent for fungal bioleaching of waste printed circuit boards (WPCBs) was employed. D-optimal response surface methodology (RSM) was utilized for optimization of the bioleaching parameters including bioleaching method (one step, two step and spent medium) and pulp densities (0.5 g L-1 to 20 g L-1 ) to maximize the recovery of Zn, Ni and Cu from WPCBs. According to the high performance liquid chromatography analysis, citric, oxalic, malic and gluconic acids were the most abundant organic acids produced by A...
April 13, 2018: Journal of Environmental Management
Chinnadurai Veeramani, Mohammed A Alsaif, Khalid S Al-Numair
Healthy plants and their constituents have been considered as a safe remedy for the treatment of obesity and obesity associated diseases. Herbacetin is a dietary flavonoid that has been explored for many pharmacological activities; but, the anti-hyperglycaemic and anti-hyperlipidemic properties of herbacetin have not yet been explored. The present study was performed to evaluate the ameliorative effect of herbacetin on high-fat diet-induced hyperglycaemia and hyperlipidemia in 57BL/6 J mice. Obesity associated insulin resistance was induced by continuously feeding the mice with high-fat diet for 10 weeks...
April 10, 2018: Chemico-biological Interactions
Sheau-Chung Tang, Jen-Hung Yang
AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations. AHAs have been used as superficial peeling agents as well as to ameliorate the appearance of keratoses and acne in dermatology. However, caution should be exercised in relation to certain adverse reactions among patients using products with AHAs, including swelling, burning, and pruritus...
April 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Aitor Balmaseda, Albert Bordons, Cristina Reguant, Joaquín Bautista-Gallego
This work is a short review of the interactions between oenological yeasts and lactic acid bacteria (LAB), especially Oenococcus oeni , the main species carrying out the malolactic fermentation (MLF). The emphasis has been placed on non- Saccharomyces effects due to their recent increased interest in winemaking. Those interactions are variable, ranging from inhibitory, to neutral and stimulatory and are mediated by some known compounds, which will be discussed. One phenomena responsible of inhibitory interactions is the media exhaustion by yeasts, and particularly a decrease in L-malic acid by some non- Saccharomyces ...
2018: Frontiers in Microbiology
Yi-Ming Tao, Song Wang, Hui-Liu Luo, Wen-Wen Yan
Peroxidase (POD) from jackfruit bulb was purified using ammonium sulfate precipitation, hydrophobic interaction and gel filtration columns. The POD was a dimer with a molecular weight of 104 kDa. The Km and Vmax values for guaiacol, gallic acid and o‑phenylenediamine (OPD) were estimated. OPD was the most suitable substrate. The enzyme showed its maximum activity at pH 5.5 and 55-60 °C. The activation energy (Ea ) of heat inactivation was estimated to be 206.40 kJ/mol. The enthalpy, free energy and entropy values for the thermal inactivation were also determined...
April 4, 2018: International Journal of Biological Macromolecules
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