keyword
https://read.qxmd.com/read/38379707/familial-hemiplegic-migraine-type-2-a-case-report-of-an-adolescent-with-atp1a2-mutation
#21
Hui Zhang, Li Jiang, Yuqi Xian, Sen Yang
This study presents a case report of a male adolescent diagnosed with familial hemiplegic migraine type 2 (FHM2), an autosomal dominant inheritance disorder caused by ATP1A2 mutation. We report the patient who presented with headache, aphasia, and left-sided weakness. Cerebrovascular disease and various infectious agents were unremarkable during the patient's extended hospital stay. Our case revealed that brain hyperperfusion in familial hemiplegic migraine (FHM) persists over an extended duration, and despite the disease being in a state of recovery, enhanced brain magnetic resonance imaging (MRI) continues to exhibit hyperperfusion...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38377838/relationship-between-shift-work-night-work-and-headache-and-migraine-risk-a-meta-analysis-of-observational-studies
#22
JOURNAL ARTICLE
Zhenzhi Wang, Tao Zhu, Meng Gong, Lin Yin, Hui Zheng
BACKGROUND: To date, there is insufficient research on whether shift work and night work increase the risk of experiencing headaches and migraines. OBJECTIVES: This study aimed to evaluate the potential association between shift work, night shift work, and headache/migraine. METHODS: We conducted a thorough search of the PubMed, Embase, and Web of Science databases up until October 2023 to identify relevant studies. Our inclusion criteria focused on observational studies that investigated the association between shift work exposure and headache/migraine outcomes...
February 16, 2024: Sleep Medicine
https://read.qxmd.com/read/38367542/exploring-shared-triggers-and-potential-etiopathogenesis-between-migraine-and-idiopathic-genetic-epilepsy-insights-from-a-multicenter-tertiary-based-study
#23
JOURNAL ARTICLE
Bengi Gül Türk, Seher Naz Yeni, Arife Çimen Atalar, Esme Ekizoğlu, Duygu Kurt Gök, Betül Baykan, Aynur Özge, Semih Ayta, Füsun Ferda Erdoğan, Bahar Taşdelen, Sibel K Velioğlu
INTRODUCTION: Migraine and epilepsy are two episodic disorders that share common pathophysiological mechanisms. The aim of our research was to assess the possible shared etiopathogenesis by analyzing the relations of headache, and seizure triggers, based on information obtained from a national cohort surveying the headache characteristics of 809 patients who had been diagnosed with idiopathic/genetic epilepsy. MATERIAL AND METHODS: Our study utilized data from a multi-center, nationwide investigation of headaches in 809 patients with idiopathic/genetic epilepsy...
February 6, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38363449/influences-of-genetic-and-environmental-factors-on-chronic-migraine-a-narrative-review
#24
REVIEW
Po-Kuan Yeh, Yu-Chin An, Kuo-Sheng Hung, Fu-Chi Yang
PURPOSE OF REVIEW: In this narrative review, we aim to summarize recent insights into the complex interplay between environmental and genetic factors affecting the etiology, development, and progression of chronic migraine (CM). RECENT FINDINGS: Environmental factors such as stress, sleep dysfunction, fasting, hormonal changes, weather patterns, dietary compounds, and sensory stimuli are critical triggers that can contribute to the evolution of episodic migraine into CM...
February 16, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38347996/prevalence-of-migraines-among-medical-students-in-saudi-arabia-a-systematic-review-and-meta-analysis
#25
REVIEW
Abdulrahman M Albeshry, Fatimah S Alsaihati, Maha Mohammed Alsuwaiyan, Rawiyah Madani, Bushra Khamis Alanazi, Abdullateef A Allebdi
Headaches are very common and often a common reason people visit emergency departments. Their prevalence among Saudi medical students was higher than the global average but aligned more closely with rates in certain countries. This regional variation may be attributed to factors such as academic pressures, lifestyle, and genetics. This systematic review and meta-analysis focused on assessing the prevalence of migraines among medical students in Saudi Arabia. Six cross-sectional studies were ultimately included in the meta-analysis, reporting a wide range of prevalence rates among Saudi medical students, from 5% to 26%...
January 2024: Curēus
https://read.qxmd.com/read/38346716/causal-association-between-systemic-lupus-erythematosus-and-the-risk-of-migraine-a-mendelian-randomization-study
#26
JOURNAL ARTICLE
Meixuan Ren, Hangtian Yu, Bing Xiao, Yan Zhao, Jiewei Yan, Jianghong Liu
BACKGROUND: Numerous studies have found that patients with systemic lupus erythematosus (SLE) often have comorbid headache, especially migraine. However, the causal relationship between genetically determined SLE and migraine risk remains unclear. Therefore, we conducted a Mendelian randomization (MR) study to explore this causal association. METHODS: Genome-wide association studies (GWAS) provided the instrumental variables. We selected summary data from GWAS of SLE as exposure (5201 SLE patients and 9066 controls)...
February 2024: Brain and Behavior
https://read.qxmd.com/read/38318429/lipedematous-scalp-occurring-in-two-female-siblings-further-evidence-for-a-genetic-role
#27
Nada Khalil, James Carton, Carolina P Fernandez, Neil P Patel
INTRODUCTION: Lipedematous scalp (LS) is a rare disorder characterized by thickening of the adipose subcutaneous scalp layer without associated hair loss. To date, there have been fewer than 100 reported cases of LS. LS occurring in siblings has not been previously reported. CASE PRESENTATION: We present a 58-year-old and 63-year-old pair of black Caribbean female siblings with LS. Scalp thickness on ultrasound of the vertex in each case was 12 mm and 11 mm from skin to periosteum, respectively (normal range: 5-6 mm)...
February 2024: Skin Appendage Disorders
https://read.qxmd.com/read/38318067/psoriasis-and-risk-of-central-neurological-disorders-in-european-populations-a-mendelian-randomization-analysis
#28
JOURNAL ARTICLE
Ya Li, Jun Cai, Huimin Chong
BACKGROUND: People with psoriasis are at a higher risk for having central neurological problems, according to previous studies; however, it is unclear if there is a genetic link between the risk of developing psoriasis and developing central neurological disorders. In this study, the possible link between genetically predisposed psoriasis and the risk of common central nervous system disorders was comprehensively investigated. METHODS: There was no overlap in the participant populations between the psoriasis and central neurological disorders genome-wide association studies, which provide the genetic resources...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38308916/astrocytic-na-k-atpases-in-physiology-and-pathophysiology
#29
JOURNAL ARTICLE
Daniela Pietrobon, Fiorenzo Conti
The Na+ , K+ ATPases play a fundamental role in the homeostatic functions of astrocytes. After a brief historic prologue and discussion of the subunit composition and localization of the astrocytic Na+ , K+ ATPases, the review focuses on the role of the astrocytic Na+ , K+ pumps in extracellular K+ and glutamate homeostasis, intracellular Na+ and Ca2+ homeostasis and signaling, regulation of synaptic transmission and neurometabolic coupling between astrocytes and neurons. Loss-of-function mutations in the gene encoding the astrocytic α2 Na+ , K+ ATPase cause a rare monogenic form of migraine with aura (familial hemiplegic migraine type 2)...
January 28, 2024: Cell Calcium
https://read.qxmd.com/read/38307672/emerging-and-future-directions-of-migraine-research-and-treatment
#30
REVIEW
Chia-Chun Chiang, David W Dodick
Despite many migraine-specific treatments that became available over the past 5 years, many patients still suffer from debilitating migraine. Emerging and future directions of migraine research and treatment should consider different aspects including revising the headache diagnostic criteria to reflect disease burden and prognosis, developing biomarkers, including genetic, serum, imaging, and deep phenotyping biomarkers to facilitate personalized medicine for headache treatment. Additionally, research should also emphasize identifying novel treatment targets for drug development...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38307670/the-evolving-concept-of-multimorbidity-and-migraine
#31
REVIEW
Claudia Altamura, Gianluca Coppola, Fabrizio Vernieri
Migraine presents with high prevalence and similar clinical course with different disorders such as neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metabolic-endocrine, and immunological conditions, which can often cooccur themselves. Multifaceted mechanisms subtend these comorbidities with a bidirectional link. First, a shared genetic load can explain the cooccurrence. Second, comorbid pathologies can promote disproportionate energetic needs, thalamocortical network dysexcitability, and systemic transient or persistent proinflammatory state, which may trigger the activation of a broad self-protective network that includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38307656/hemiplegic-migraine
#32
JOURNAL ARTICLE
Irene de Boer, Jakob M Hansen, Gisela M Terwindt
Hemiplegic migraine (HM) is a rare subtype of migraine with aura in which the aura phase includes transient motor weakness. Diagnosis is based on the International Classification of Headache Disorders criteria (ICHD-3). The most important diagnostic tools remain a patient interview, neurological examination during attacks, and exclusion of other disorders, such as epilepsy, stroke, encephalitis and secondary headache syndromes. Hemiplegic migraine can occur either familial or sporadic. Three genes, CACNA1A, ATP1A2, and SCN1A have been identified...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38307655/menstrually-associated-migraine
#33
REVIEW
Eleonora De Matteis, Raffaele Ornello, Simona Sacco
Menstrually related migraine is a disabling condition affecting 35% to 54% females with migraine during their fertile years. The International Headache Classification distinguishes menstrually related migraine from pure menstrual migraine based on the occurrence of the attacks even outside the perimenstrual periods. Hormonal fluctuations are the main driver for the disease in subjects with genetic susceptibility and alterations of brain structures and connectivity. Menstrually related attacks are often particularly severe and disabling requiring proper management...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38303905/are-genetics-the-predicting-factor-for-the-success-of-migraine-surgery-a-report-on-identical-twins
#34
JOURNAL ARTICLE
Elisabeth Russe, Sandra Scharfetter, Fabian Köninger, Mark Rinnerthaler, Gottfried Wechselberger
Migraine affects more than 1 billion people globally, with distinct genetic variations influencing susceptibility. Thereby, genetic variations play a key role in the probability of developing migraine. However, personalized genetic analysis-based treatment options in migraine treatments are limited. Notably, surgical deactivation of extracranial trigger has shown efficacy in the treatment of migraine patients with identifiable trigger points in specific anatomical locations in the head and neck region. We present the first case of monozygotic twin sisters, both experiencing occipital and temporal-triggered migraine headaches with identical history and characteristics and without response to conservative migraine treatments...
March 2024: JPRAS Open
https://read.qxmd.com/read/38288634/regulation-of-headache-response-and-transcriptomic-network-by-the-trigeminal-ganglion-clock
#35
JOURNAL ARTICLE
Chorong Han, Ji Ye Lim, Nobuya Koike, Sun Young Kim, Kaori Ono, Celia K Tran, Elizaveta Mangutov, Eunju Kim, Yanping Zhang, Lingyong Li, Amynah A Pradhan, Kazuhiro Yagita, Zheng Chen, Seung-Hee Yoo, Mark J Burish
OBJECTIVE: To characterize the circadian features of the trigeminal ganglion in a mouse model of headache. BACKGROUND: Several headache disorders, such as migraine and cluster headache, are known to exhibit distinct circadian rhythms of attacks. The circadian basis for these rhythmic pain responses, however, remains poorly understood. METHODS: We examined trigeminal ganglion ex vivo and single-cell cultures from Per2::LucSV reporter mice and performed immunohistochemistry...
January 30, 2024: Headache
https://read.qxmd.com/read/38281051/no-causal-association-between-allergic-rhinitis-and-migraine-a-mendelian-randomization-study
#36
JOURNAL ARTICLE
Hao Lv, Kunyu Liu, Yulie Xie, Yunfei Wang, Siyuan Chen, Peiqiang Liu, Mengting Guan, Jianchao Cong, Yu Xu
PURPOSE: Allergic rhinitis (AR) and migraine are among the most common public health problems worldwide. Observational studies on the correlation between AR and migraine have reported inconsistent results. This study aimed to investigate the causal relationship of AR with migraine and its subtypes, including migraine with aura (MA) and migraine without aura (MO). METHODS: Bidirectional two-sample Mendelian randomization (MR) analysis was performed with publicly available summary-level statistics of large genome-wide association studies to estimate the possible causal effects...
January 27, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38277045/-migraine-and-mitochondrial-diseases-energy-deficit-in-the-brain
#37
JOURNAL ARTICLE
Lucia Hämmerl, Torsten Kraya
Mitochondrial diseases are complex metabolic disorders caused by genetic mutations and lead to impaired energy production in the mitochondria of cells. The clinical spectrum ranges from severe multiorgan involvement in early childhood to mild monosymptomatic courses in adulthood. The brain, heart, and skeletal muscles are particularly affected due to their high energy demands. Headaches in general and migraine in particular, occur disproportionately more frequently in patients with mitochondrial diseases. In recent years similarities in the pathomechanism of mitochondrial diseases and migraine have been investigated in numerous biochemical, genetic, and therapeutic studies...
January 26, 2024: Der Nervenarzt
https://read.qxmd.com/read/38273253/migraine-a-borderland-disease-to-epilepsy-near-it-but-not-of-it
#38
REVIEW
Jakob Paungarttner, Martina Quartana, Lucrezia Patti, Barbora Sklenárová, Fatemeh Farham, Inés Hernando Jiménez, M Gokcen Soylu, Irina Maria Vlad, Semih Tasdelen, Teresa Mateu, Oreste Marsico, Federica Reina, Viktoria Tischler, Christian Lampl
BACKGROUND: Migraine and epilepsy are two paroxysmal chronic neurological disorders affecting a high number of individuals and being responsible for a high individual and socioeconomic burden. The link between these disorders has been of interest for decades and innovations concerning diagnosing and treatment enable new insights into their relationship. FINDINGS: Although appearing to be distinct at first glance, both diseases exhibit a noteworthy comorbidity, shared pathophysiological pathways, and significant overlaps in characteristics like clinical manifestation or prophylactic treatment...
January 26, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38255689/migraine-comorbidities
#39
REVIEW
Dan Iulian Cuciureanu, Cătălina Elena Bistriceanu, Georgiana-Anca Vulpoi, Tudor Cuciureanu, Florina Antochi, Adina-Maria Roceanu
Novel knowledge about the interrelationships and reciprocal effects of migraine and epilepsy, migraine and mood disorders, or migraine and irritable bowel syndrome has emerged in recent decades. Over time, comorbid pathologies associated with migraine that share common physiopathological mechanisms were studied. Among these studied pathologies is epilepsy, a disorder with common ion channel dysfunctions as well as dysfunctions in glutamatergic transmission. A high degree of neuronal excitement and ion channel abnormalities are associated with epilepsy and migraine and antiepileptic drugs are useful in treating both disorders...
January 2, 2024: Life
https://read.qxmd.com/read/38231105/-neurology-what-s-new-in-2023
#40
JOURNAL ARTICLE
Beatrice Pizzarotti, Amélie Buhler-Heintze, Gilles Allali, Olivier Rouaud, Julien Bally, Patrik Michel, Lorenz Hirt, Marie Théaudin, Caroline Pot Kreis, Philippe Ryvlin, Arseny Sokolov, Andrea Rossetti, Jan Novy, Renaud Du Pasquier
The year 2023 is marked by the arrival on the market of lecanemab for the treatment of Alzheimer's disease. New biomarkers have demonstrated their usefulness in monitoring peripheral neuropathies and diagnosing synucleinopathies. A genetic study has highlighted the role of nervous system cells in the risk of progression of multiple sclerosis (MS). The adverse effects of anticonvulsant treatments after prenatal exposure and on lipid metabolism have been clarified. New anti-CGRP treatments have demonstrated their efficacy in migraine attacks and chronic migraines...
January 17, 2024: Revue Médicale Suisse
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