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https://www.readbyqxmd.com/read/29227690/effect-of-the-induction-of-transgenerational-obesity-on-maternal-fetal-parameters
#1
Thaigra Sousa Soares, Ana Paula Andreolla, Carolina Abreu Miranda, Eduardo Klöppel, Luhara Silva Rodrigues, Rafaianne Queiroz Moraes-Souza, Débora Cristina Damasceno, Gustavo Tadeu Volpato, Kleber Eduardo Campos
Maternal obesity can cause complications for both women and their offspring for generations. Therefore, we intended to verify the repercussions of induction of transgenerational obesity on biochemical parameters, reproductive performance, and congenital anomaly frequency in Wistar rats. Female rats were used from successive generations. The female rats of parental generation (F0, n=10) were mated to obtain their offspring (F1 generation). F1 female rats received a monosodium glutamate (MSG) solution to induce obesity (n=07) or vehicle (control, n=06) during the neonatal period...
December 11, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29212355/the-utility-of-contrast-enhanced-hypodense-sign-for-the-diagnosis-of-pulmonary-invasive-mold-disease-in-patients-with-haematological-malignancies
#2
Claudia Sassi, Marta Stanzani, Russell E Lewis, Giancarlo Facchini, Alberto Bazzocchi, Michele Cavo, Giuseppe Battista
OBJECTIVE: The hypodense sign (HyS) on CT imaging is highly suggestive of pulmonary invasive mould disease (IMD) in patients with haematological malignancies, but its diagnostic utility has not been systematically evaluated on contrast-enhanced CT. The objective of this study was to compare the diagnostic performance of the HyS to other common CT findings in a cohort of haematology patients with proven, probable or possible IMD based on EORTC/MSG criteria. METHODS: We analyzed the diagnostic performance of the HyS to other common CT signs among 127 neutropenic patients with haematological malignancies submitted to both noncontrast-enhanced and contrast-enhanced CT scans of the lungs, including CT pulmonary angiography (CTPA)...
December 7, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29188030/monosodium-glutamate-as-a-tool-to-reduce-sodium-in-foodstuffs-technological-and-safety-aspects
#3
REVIEW
Hellen D B Maluly, Adriana P Arisseto-Bragotto, Felix G R Reyes
Sodium chloride (NaCl) is the most commonly used ingredient to provide salty taste to foods. However, excess sodium in the bloodstream has been associated with the development of several chronic noncommunicable diseases. In order to limit sodium intake to levels considered safe, the World Health Organization (WHO) recommends for adults a daily intake of not more than 5 g of NaCl (less than 2 g of sodium). One of the strategic actions recommended by the Pan American Health Organization (PAHO) to reduce sodium intake is reformulation of processed foods...
November 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/29187564/a-comparison-of-aspergillus-and-mucorales-pcr-testing-of-different-bal-fractions-from-patients-with-suspected-invasive-pulmonary-fungal-disease
#4
Jan Springer, P Lewis White, Johanna Kessel, Imke Wieters, Daniel Teschner, Daniel Korczynski, Tobias Liebregts, Oliver A Cornely, Stefan Schwartz, Thomas Elgeti, Lisa Meintker, Stefan W Krause, Raquel B Posso, Werner J Heinz, Sandra Fuhrmann, Jörg Janne Vehreschild, Hermann Einsele, Volker Rickerts, Juergen Loeffler
In patients with haematological malignancies, bronchoalveolar lavage fluid specimens (BALF) are commonly used for the diagnosis of mould infections. However, it is not clear whether the cellular pellet (P) or the supernatant fraction (S) of the BALF is optimal for molecular diagnostic testing. Thus, 99 BALF specimens from 96 haematology patients with or without allogeneic hematopoietic stem cell transplant were collected. Pellets and supernatants were processed alone and in combination (S/P) by two fungal-specific real-time PCR assays compliant with international recommendations...
November 29, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29127646/can-we-spice-up-our-christmas-dinner-busting-the-myth-of-the-chinese-restaurant-syndrome
#5
N W E van den Berg, J Neefs, W R Berger, S W E Baalman, E Meulendijks, M Kawasaki, E M Kemper, F R Piersma, M W Veldkamp, R Wesselink, S P J Krul, J R de Groot
BACKGROUND: Monosodium glutamate (MSG), also referred to as Vetsin or E621, is a flavour enhancer frequently used in Asian cuisine and abundantly present in the famous Chinese dish Peking duck. MSG is notorious for triggering the onset of the so-called 'Chinese restaurant syndrome' (CRS), a complex of unpleasant symptoms, which might include flushing, sweating and the onset of atrial fibrillation (AF). This study aims to determine the effects of MSG on the occurrence of AF. METHODS: We conducted a placebo self-controlled single-arm study in the Academic Medical Centre in Amsterdam...
December 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29125056/monosodium-glutamate-and-treadmill-exercise-anxiety-like-behavior-and-spreading-depression-features-in-young-adult-rats
#6
Suênia Marcele Vitor-de-Lima, Larissa de Brito Medeiros, Regina de Deus Lira Benevides, Catarina Nicácio Dos Santos, Nahara Oliveira Lima da Silva, Rubem Carlos Araújo Guedes
OBJECTIVES: The route of administration is an important factor in determining the action of some drugs. We previously demonstrated that subcutaneous monosodium glutamate (MSG) accelerated cortical spreading depression (CSD) in the rat and that treadmill exercise attenuated this effect. This study evaluated whether other routes of administration exert the same action by testing orogastric (gavage) and topical cortical MSG administration in treadmill-exercised and sedentary rats. Additionally, in the orogastric treatment we tested anxiety-like behavior...
November 10, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29124095/circular-transcriptome-sequencing-of-the-middle-silk-gland-and-posterior-silk-gland-in-the-bombyx-mori
#7
Huaiyan Gan, Tieshan Feng, Yuqian Wu, Chun Liu, Qingyou Xia, Tingcai Cheng
Circular transcriptome sequencing of the middle silk gland (MSG) and posterior silk gland (PSG) in the Bombyx mori are presented. The middle silk gland and posterior silk gland were collected from the third day of fifth-instar B.mori larvae. The circular RNAs enriched by using RNase R to degrade the linear RNA molecules, and circular RNA sequencing (circRNA-seq) was performed using an Illumina Hiseq. 2500 sequencing platform. Samples are described in the SRA portal (SRP100385) and FASTQ files have been deposited in Sequence Read Archive (accession numbers: SRX2577343 and SRX2577342)...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29119727/monosodium-glutamate-suppresses-the-female-reproductive-function-by-impairing-the-functions-of-ovary-and-uterus-in-rat
#8
Mukti Mondal, Kaushik Sarkar, Partha Pratim Nath, Goutam Paul
The aim of the present study was to examine the effect of monosodium glutamate (MSG) on the functions of ovary and uterus in rat. Virgin female rats of Charles Foster strain (120 gms approximately) were administrated MSG by oral gavage at a dose level of 0.8, 1.6, 2.4 gm/kgBW/day, respectively for 30 and 40 days duration. We observed a significant decrease in the duration of proestrus, estrus and metestrus phases, and increase in the duration of diestrus phase and diestrus index compared to control. We found significant increase in the levels of serum LH, FSH and estradiol in test groups of rat...
November 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29117134/ginger-and-propolis-exert-neuroprotective-effects-against-monosodium-glutamate-induced-neurotoxicity-in-rats
#9
Usama K Hussein, Nour El-Houda Y Hassan, Manal E A Elhalwagy, Amr R Zaki, Huda O Abubakr, Kalyan C Nagulapalli Venkata, Kyu Yun Jang, Anupam Bishayee
Central nervous system cytotoxicity is linked to neurodegenerative disorders. The objective of the study was to investigate whether monosodium glutamate (MSG) neurotoxicity can be reversed by natural products, such as ginger or propolis, in male rats. Four different groups of Wistar rats were utilized in the study. Group A served as a normal control, whereas group B was orally administered with MSG (100 mg/kg body weight, via oral gavage). Two additional groups, C and D, were given MSG as group B along with oral dose (500 mg/kg body weight) of either ginger or propolis (600 mg/kg body weight) once a day for two months...
November 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29104637/evaluation-of-the-diagnostic-performance-of-panfungal-polymerase-chain-reaction-assay-in-invasive-fungal-diseases
#10
Guo-Jun Cao, Zhi-Fang Xing, Li Hua, Yu-Hua Ji, Jia-Bin Sun, Zhen Zhao
Timely diagnosis of invasive fungal diseases (IFDs) is important, as delays in treatment initiation are associated with increased mortality rates. However, early diagnosis of IFDs in immunocompromised patients remains difficult. The conventional diagnostic methods currently used for IFDs are not sufficiently effective. Molecular tests, such as polymerase chain reaction (PCR)-based assays, have great potential to improve the early diagnosis of IFDs due to their sensitivity and specificity. In the present study, the diagnostic performance of panfungal PCR assays in IFD patients who received bone marrow transplantation was evaluated...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103481/comparison-between-multi-shot-gradient-echo-epi-and-balanced-ssfp-in-unenhanced-3t-mra-of-thoracic-aorta-in-healthy-volunteers
#11
Yuji Iyama, Takeshi Nakaura, Yasunori Nagayama, Seitaro Oda, Daisuke Utsunomiya, Masafumi Kidoh, Hideaki Yuki, Kenichiro Hirata, Tomohiro Namimoto, Mika Kitajima, Kosuke Morita, Yoshinori Funama, Atsushi Takemura, Shinichi Tokuyasu, Tomoyuki Okuaki, Yasuyuki Yamashita
PURPOSE: The purpose of this study was to compare scan time and image quality between magnetic resonance angiography (MRA) of the thoracic aorta using a multi-shot gradient echo planar imaging (MSG-EPI) and MRA using balanced steady-state free precession (b-SSFP). MATERIALS AND METHODS: Healthy volunteers (n=17) underwent unenhanced thoracic aorta MRA using balanced steady-state free precession (b-SSFP) and MSG-EPI sequences on a 3T MRI. The acquisition time, total scan time, signal-to-noise ratio (SNR) of the thoracic aorta, and the coefficient of variation (CV) of thoracic aorta were compared with paired t-tests...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29099794/hydrogel-film-immobilized-lactobacillus-brevis-rk03-for-%C3%AE-aminobutyric-acid-production
#12
Yi-Huang Hsueh, Wen-Chang Liaw, Jen-Min Kuo, Chi-Shin Deng, Chien-Hui Wu
Hydrogels of 2-hydroxyethyl methacrylate/polyethylene glycol diacrylate (HEMA/PEGDA) have been extensively studied for their use in biomedical and pharmaceutical applications owing to their nontoxic and highly hydrophilic characteristics. Recently, cells immobilized by HEMA/PEGDA hydrogels have also been studied for enhanced production in fermentation. Hydrogel films of HEMA/PEGDA copolymer were generated by Ultraviolet (UV)-initiated photopolymerization. The hydrogel films were used to immobilize viable Lactobacillus brevis RK03 cells for the bioconversion of monosodium glutamate (MSG) to γ-aminobutyric acid (GABA)...
November 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29097195/selenofuranoside-improves-long-term-memory-deficits-in-rats-after-exposure-to-monosodium-glutamate-involvement-of-na-k-atpase-activity
#13
Juliana Bernera Ramalho, Aryele Pinto Izaguirry, Melina Bucco Soares, Cristiano Chiapinotto Spiazzi, Natasha Frasson Pavin, Ricardo Ferreira Affeldt, Diogo Seibert Lüdtke, Simone Pinton, Francielli Weber Santos, Marina Prigol
Monosodium glutamate (MSG) is the most widely used additive in the food industry; however, some adverse effects of this additive, including functional, learning, and behavioral alterations, have been observed in experimental animals and humans. Studies have shown learning and memory impairment in adult animals exposed to MSG. However, studies relating exposure to MSG to acetylcholinesterase (AChE) and Na(+), K(+)-ATPase activities and memory damage are still scarce in the literature. The aim of the present study was to assess the possible protective effects of selenofuranoside, an organoselenium compound, against the impairment of long-term memory, Na(+), K(+)-ATPase and AChE activities, and oxidative stress after MSG exposure in rats...
October 31, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29074164/defective-regulation-of-l1-endogenous-retroelements-in-primary-sjogren-s-syndrome-and-systemic-lupus-erythematosus-role-of-methylating-enzymes
#14
Clio P Mavragani, Adrianos Nezos, Irina Sagalovskiy, Surya Seshan, Kyriakos A Kirou, Mary K Crow
OBJECTIVE: To investigate whether altered DNA methylation contributes to the inappropriate expression of LINE-1 (L1) retroelements in primary Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE). METHODS: Minor salivary glands (MSG) were obtained from 42 patients with primary SS [23 without adverse predictors for lymphoma development (SS-low risk), 7 SS-high risk and 12 complicated by B-cell lymphoma (SS-lymphoma)] and 17 sicca controls (SC). Additionally, kidney biopsy specimens and PBMCs were obtained from 23 and 73 lupus patients, respectively...
October 23, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29027308/animal-models-for-analyzing-metabolic-syndrome-associated-liver-diseases
#15
REVIEW
Koichi Tsuneyama, Kazuchika Nishitsuji, Minoru Matsumoto, Tomoko Kobayashi, Yuki Morimoto, Takaaki Tsunematsu, Hirohisa Ogawa
Metabolic syndrome (MS) is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases affecting the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease (NAFLD) and its progressive variant, nonalcoholic steatohepatitis (NASH). NASH is known to progress to liver cirrhosis and hepatocellular carcinoma (HCC). Excellent animal models for determining the mechanism of pathogenesis and establishing therapeutic treatment of NASH/HCC are strongly required worldwide...
October 12, 2017: Pathology International
https://www.readbyqxmd.com/read/29022648/probiotics-for-experimental-obesity-prevention-focus-on-strain-dependence-and-viability-of-composition
#16
Nazarii Kobyliak, Tetyana Falalyeyeva, Tetyana Beregova, Mykola Spivak
INTRODUCTION: a comparative animal study of the efficacy of intermittent short-course administration of lyophilised single-, three-, and live multistrain probiotic on obesity. METHODS: We included 70 rats divided into seven groups (n = 10 in each). Rats of group I were intact. Newborn rats of groups II-VII were injected with monosodium glutamate (MSG) (4 mg/g). Rats of group II (MSG-obesity group) were untreated. The group III-V received lyophilised monoprobiotics B...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29020284/performance-of-targeted-fungal-sequencing-for-culture-independent-diagnosis-of-invasive-fungal-disease
#17
Carlos A Gomez, Indre Budvytiene, Allison J Zemek, Niaz Banaei
Background: Identification of fungi causing invasive fungal disease (IFD) is critical for guiding antifungal therapy. We describe the performance and clinical impact of a targeted panfungal polymerase chain reaction (PCR) amplicon sequencing assay for culture-independent diagnosis of IFD. Methods: Between January 2009 and September 2016, 233 specimens, consisting of fresh and formalin-fixed, paraffin-embedded (FFPE) tissues and sterile body fluids with known diagnosis of IFD based on reference method results (n = 117), and specimens with negative fungal culture, but with microscopic and ancillary findings indicative of IFD (n = 116), were included...
November 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019097/efficacy-of-conventional-and-liposomal-povidone-iodine-in-infected-mesh-skin-grafts-an-exploratory-study
#18
Peter M Vogt, Joerg Hauser, Stefan Mueller, Bjoern Bosse, Michael Hopp
INTRODUCTION: Infection is a major threat to wound healing and a leading cause of graft loss in patients undergoing meshed skin grafts (MSGs). Therefore, topical antisepsis is important in the overall treatment scheme. METHODS: An exploratory satellite group of 14 patients with infected MSGs were enrolled as part of a prospective, randomized, controlled, parallel-group, open-label, pilot Phase II study that investigated the efficacy and tolerability of 3% liposomal povidone-iodine hydrogel (PVP-ILH, Repithel(®); RepiGel(®)) versus chlorhexidine gauze in non-infected MSGs...
October 10, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28993739/increased-subjective-distaste-and-altered-insula-activity-to-umami-tastant-in-patients-with-bulimia-nervosa
#19
Rikukage Setsu, Yoshiyuki Hirano, Miki Tokunaga, Toru Takahashi, Noriko Numata, Koji Matsumoto, Yoshitada Masuda, Daisuke Matsuzawa, Masaomi Iyo, Eiji Shimizu, Michiko Nakazato
The aim of this study was to examine differences in brain neural activation in response to monosodium glutamate (MSG), the representative component of umami, between patients with bulimia nervosa (BN) and healthy women (HW) controls. We analyzed brain activity after ingestion of an MSG solution using functional magnetic resonance imaging (fMRI) in a group of women with BN (n = 18) and a group of HW participants (n = 18). Both groups also provided a subjective assessment of the MSG solution via a numerical rating scale...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28989843/a-novel-lumbar-motion-segment-classification-to-predict-changes-in-segmental-sagittal-alignment-after-lateral-interbody-fixation
#20
Frank L Acosta, Vivek A Mehta, Anush Arakelyan, Doniel Drazin, Clarissa Cortland, Patrick C Hsieh, John C Liu, Martin H Pham
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: Lateral interbody fixation is being increasingly used for the correction of segmental sagittal parameters. One factor that affects postoperative correction is the resistance afforded by posterior hypertrophic facet joints in the degenerative lumbar spine. In this article, we describe a novel preoperative motion segment classification system to predict postoperative correction of segmental sagittal alignment after lateral lumbar interbody fusion...
October 2017: Global Spine Journal
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