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https://www.readbyqxmd.com/read/29443544/taste-sensitivity-to-a-mixture-of-monosodium-glutamate-and-inosine-5-monophosphate-by-mice-lacking-both-subunits-of-the-t1r1-t1r3-amino-acid-receptor
#1
Ginger D Blonde, Susan P Travers, Alan Craig Spector
The taste of L-glutamate and its synergism with 5'-ribonucleotides is thought to be primarily mediated through the T1R1+T1R3 heterodimer in some mammals including rodents and humans. While knockout (KO) mice lacking either receptor subunit show impaired sensitivity to a range of monosodium glutamate (MSG) concentrations mixed with 2.5mM inosine 5'-monophosphate (IMP) in amiloride, wild-type (WT) controls can detect this IMP concentration, hindering direct comparison between genotypes. Moreover, some residual sensitivity persists in the KO group, suggesting that the remaining subunit could maintain a limited degree of function...
February 14, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29441869/monosodium-glutamate-induced-obesity-changed-the-expression-and-activity-of-glutathione-s-transferases-in-mouse-heart-and-kidney
#2
I Boušová, Š Košťáková, P Matoušková, H Bártíková, B Szotáková, L Skálová
Obesity may affect activity and/or expression of enzymes participating in xenobiotics' detoxification and antioxidant defense. This study sought to investigate the activities and expression of cardiac and renal glutathione S-transferase (GST) isoforms in order to reveal possible differences between obese and control mice. For this purpose, mice with monosodium glutamate (MSG)-induced obesity were used as an experimental model. Obesity was induced in newborn male mice by repeated s.c. administration of MSG. At 8 months of age, mice were sacrificed and specific activity, protein and mRNA expressions levels of GSTs were analyzed in their heart and kidney...
May 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29429323/properties-of-kimchi-fermented-with-gaba-producing-lactic-acid-bacteria-as-a-starter
#3
Kang Wook Lee, Jae Min Shim, Zhuang Yao, Jeong A Kim, Jeong Hwan Kim
Kimchi was prepared with a starter, Lactobacillus zymae GU240 producing γ-aminobutyric acid (GABA), and one precursor of GABA (glutamic acid, glutamic acid mono sodium salt (MSG), or kelp extract). L. zymae GU240, an isolate from kimchi, can grow at 7% NaCl and low temperature. Five different kimchi samples were fermented for 20 weeks at -1°C. Kimchi with starter alone could not produce GABA. GABA content was highest in kimchi with co-inoculation of starter and MSG (1%, w/w). Kimchi co-inoculated with a starter and kelp extract powder (3%, w/w) had the second highest GABA content...
February 13, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29412471/untargeted-profiling-of-glycyrrhiza-glabra-extract-with-comprehensive-two-dimensional-liquid-chromatography-mass-spectrometry-using-multi-segmented-shift-gradients-in-the-second-dimension-expanding-the-metabolic-coverage
#4
Yong Foo Wong, Francesco Cacciola, Soraya Fermas, Solange Riga, Darryl James, Valeria Manzin, Brice Bonnet, Philip John Marriott, Paola Dugo, Luigi Mondello
Metabolic profiling of Glycyrrhiza glabra using comprehensive two-dimensional liquid chromatography (LC × LC) coupled with photodiode array (PDA) and mass spectrometry (MS) detection is described. The separation was conducted under reversed-phase conditions, using a combination of first dimension (1 D) 150 mm microbore cyano column utilising 2.7 μm diameter (dp ) particles, and second dimension (2 D) 50 mm superficially porous octadecylsilica column with 2.7 μm dp particles. A multi-segmented shift gradient (MSG) for the 2 D separation was developed, and the orthogonality achieved was compared with other modes of gradients, such as full in-fraction, and shift gradient systems...
February 7, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29402603/monosodium-glutamate-impairs-the-contraction-of-uterine-visceral-smooth-muscle-ex-vivo-of-rat-through-augmentation-of-acetylcholine-and-nitric-oxide-signaling-pathways
#5
Mukti Mondal, Kaushik Sarkar, Partha Pratim Nath, Ashma Khatun, Sanghamitra Pal, Goutam Paul
The aim of the study was to examine the toxic effects of Monosodium glutamate (MSG), an extensively used food additive, on the contraction of uterine visceral smooth muscle (UVSM) in rat and to elucidate the probable neurocrine mechanism involved in it. MSG produced significant potentiation of the force and inhibition of frequency of uterus recorded ex vivo in chronic MSG exposure and in single dose acute experiments. MSG also produced significant potentiation of force of acetylcholine induced contraction and no alterations in atropine induced contraction of uterus...
February 2, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29385105/a-rotational-gyroscope-with-a-water-film-bearing-based-on-magnetic-self-restoring-effect
#6
Dianzhong Chen, Xiaowei Liu, Haifeng Zhang, Hai Li, Rui Weng, Ling Li, Wanting Rong, Zhongzhao Zhang
Stable rotor levitation is a challenge for rotational gyroscopes (magnetically suspended gyroscopes (MSG) and electrostatically suspended gyroscopes (ESG)) with a ring- or disk-shaped rotor, which restricts further improvement of gyroscope performance. In addition, complicated pick-up circuits and feedback control electronics propose high requirement on fabrication technology. In the proposed gyroscope, a ball-disk shaped rotor is supported by a water-film bearing, formed by centrifugal force to deionized water at the cavity of the lower supporting pillar...
January 31, 2018: Sensors
https://www.readbyqxmd.com/read/29374793/taurine-supplementation-prevents-endothelial-dysfunction-and-attenuates-structural-changes-in-aortas-from-hypothalamic-obese-rats
#7
Valéria F Leão, Letícia L D M Ferreira, Cinthya M Melo, Maria L Bonfleur, Leandro L da Silva, Everardo M Carneiro, Juliana M Raimundo, Rosane A Ribeiro
PURPOSE: Obesity predisposes to cardiovascular and metabolic diseases. The amino acid, L-taurine (Tau), regulates glucose and lipid homeostasis and vascular function. Here we investigated whether Tau supplementation prevents endothelial dysfunction in the thoracic aortas of monosodium glutamate-induced obese (MSG) rats. METHODS: Male rats received subcutaneous injections of MSG (4 mg/kg body weight/day) or saline (control group, CTL) during the first five days of life...
January 27, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29371098/distribution-of-fos-immunoreactive-neurons-in-the-gustatory-cortex-elicited-by-intra-oral-infusion-of-taste-solutions-in-conscious-rats
#8
Michael S King
The location of neurons in the gustatory cortex (GC) activated by intra-oral infusion of solutions in conscious rats was mapped using Fos immunohistochemistry. Groups of adult male Wistar rats (N's=5) received an infusion of one of the following: dH2O, 0.1 or 1.0M NaCl, 0.1 or 1.0M sucrose, 0.32M MSG (with 100µM amiloride and 2.5M inosine 5'-monophosphate), 0.03M HCl, or 0.003M QHCl delivered via an intra-oral cannula (0.233ml/min for 5 min). Unstimulated control rats received no infusion. Taste reactivity (TR) behaviors were videotaped and scored...
January 22, 2018: Brain Research
https://www.readbyqxmd.com/read/29361207/blood-t-follicular-regulatory-cells-t-follicular-helper-cells-ratio-marks-ectopic-lymphoid-structure-formation-and-pd-1-icos-t-follicular-helper-cells-indicate-disease-activity-in-primary-sj%C3%A3-gren-s-syndrome
#9
Valter R Fonseca, Vasco C Romão, Ana Agua-Doce, Mara Santos, Dolores López-Presa, Ana Cristina Ferreira, João Eurico Fonseca, Luis Graca
OBJECTIVES: To investigate whether the balance of blood T follicular helper (Tfh) and Foxp3+ T follicular regulatory (Tfr) cells can inform on ectopic lymphoid neogenesis and disease activity in primary Sjögren's syndrome (SS). METHODS: We prospectively recruited 56 patients with clinical suspicion of SS, 16 of which subsequently fulfilled American European Consensus Group primary SS classification criteria and were compared with 16 patients with non-Sjögren sicca syndrome...
January 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29329874/a-survey-of-free-glutamic-acid-in-foods-using-a-robust-lc-ms-ms-method
#10
Nur Cebi, Canan Ekinci Dogan, Elmas Oktem Olgun, Osman Sagdic
An effective and simultaneous liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used with the aim of quantifying monosodium glutamate (MSG) in foodstuffs, such as chips, taste cubes, sauces and soups. The results were linear (R2 = 1), with very low LOD and LOQ values, 1.0 µg/kg, 5.0 µg/kg, respectively. Excellent repeatability and reproducibility were also achieved. This highly sensitive and robust LC-MS/MS technique was applied successfully for the detection and quantification of MSG in a wide variety of foodstuffs...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29328403/arcuate-nucleus-neurons-are-not-essential-for-the-preprandial-peak-in-plasma-ghrelin-after-neonatal-monosodium-glutamate-treatment
#11
Qing-Chun Li, Qing-Feng Li, Yan-Lin Wang, Hong-Liang Sun, Zheng-Yao Jiang
The aim of the present study was to determine whether arcuate nucleus (ARC) lesions affect the ghrelin level in the plasma and the stomach in monosodium glutamate (MSG)‑treated mice. The aim of the present study was to investigate whether the ARC was destroyed in mice treated neonatally with MSG, and whether the ARC lesions affect the ghrelin level in the plasma and lipid mobilization in MSG‑treated mice. The results revealed that MSG led to a marked reduction in ARC cresyl violet staining, tyrosine hydroxylase-immunoreactive (IR) neurons and neuropeptide Y‑IR fibers, compared with saline controls...
January 5, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29311399/efficacy-of-probiotics-and-smectite-in-rats-with-non-alcoholic-fatty-liver-disease
#12
Nazarii Kobyliak, Ludovico Abenavoli, Tetyana Falalyeyeva, Tetyana Beregova
INTRODUCTION AND AIM: Today probiotics have been suggested as a treatment for the prevention of non-alcoholic fatty liver disease (NAFLD). Smectite is a natural silicate that binds to digestive mucous and has the ability to bind endo- and exotoxins. The present study was designed to determine whether probiotics plus smectite is superior to probiotic alone on the monosodium glutamate (MSG) induced NAFLD model in rats. MATERIALS AND METHODS: We included 60 rats divided into 4 groups 15 animals in each...
January 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29304190/enhancement-of-saltiness-perception-by-monosodium-glutamate-taste-and-soy-sauce-odor-a-near-infrared-spectroscopy-study
#13
Takuya Onuma, Hiroaki Maruyama, Nobuyuki Sakai
Previous studies have reported that the umami taste of monosodium L-glutamate (MSG) and salty-smelling odors (e.g., soy sauce, bacon, sardines) enhance the perception of saltiness. This study aimed to investigate the neural basis of the enhancement of saltiness in human participants using functional near-infrared spectroscopy (fNIRS). University students who had passed a taste panel test participated in this study. Sodium chloride solutions were presented with or without either 0.10% MSG or the odor of soy sauce...
January 3, 2018: Chemical Senses
https://www.readbyqxmd.com/read/29300336/characterization-of-a-potential-probiotic-lactobacillus-brevis-rk03-and-efficient-production-of-%C3%AE-aminobutyric-acid-in-batch-fermentation
#14
Chien-Hui Wu, Yi-Huang Hsueh, Jen-Min Kuo, Si-Jia Liu
Lactic acid bacteria were isolated from fish and evaluated for their γ-aminobutyric acid (GABA)-producing abilities. Out of thirty-two isolates, Lactobacillus brevis RK03 showed the highest GABA production ability. The effects of various fermentation parameters including initial glutamic acid level, culture temperature, initial pH, and incubation time on GABA production were investigated via a singleparameter optimization strategy. For industrial large-scale production, a low-cost GABA producing medium (GM) broth was developed for fermentation with L...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29291462/analysis-of-performance-and-stress-caused-by-a-simulation-of-a-mass-casualty-incident
#15
Antonio Nieto Fernández-Pacheco, Rafael Castro Delgado, Pedro Arcos González, José Luis Navarro Fernández, José Joaquín Cerón Madrigal, Laura Juguera Rodriguez, Nuria Perez Alonso, David Armero-Barranco, María Lidon López Iborra, Escribano Tortosa Damian, Manuel Pardo Rios
OBJECTIVE: To determine the stress that is potentially produced in professional health workers due to a mass casualty incident (MCI) simulated exercise, and its relation to prior academic training and the role played in the simulation. METHODS: Observational study of stress in a MCI. For this work, two MCI drills comprised of 40 victims each were conducted. Two randomized groups of 36 students each were created: Master's Students Group (MSG) and Undergraduate Student Group (USG)...
December 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29280389/the-effects-of-black-garlic-on-the-working-memory-and-pyramidal-cell-number-of-medial-prefrontal-cortex-of-rats-exposed-to-monosodium-glutamate
#16
Titis Nurmasitoh, Dwi Cahyani Ratna Sari, Ginus Partadiredja
Monosodium glutamate-induced exitotoxicity causes oxidative stress in many brain areas, including the medial prefrontal cortex. The ethanolic garlic (Allium sativum) extract is considered as a neuroprotective substance. The present study aimed at investigating the effects of the ethanolic fermented garlic extract on the working memory and the pyramidal cell number of the medial prefrontal cortex of adolescent male Wistar rats exposed to monosodium glutamate (MSG). Twenty-five rats were randomly divided into five groups...
December 27, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29278027/environmental-enrichment-improved-cognitive-deficits-more-in-peri-adolescent-than-in-adult-rats-after-postnatal-monosodium-glutamate-treatment
#17
S Madhavadas, S Subramanian, B M Kutty
Exposure to enriched environment (EE) is known to promote sensory, cognitive, and motor stimulation with intensified levels of novelty and complexity. In this study, we investigated the positive regulatory effect of short-term exposure to EE on establishing functional recovery in monosodium glutamate (MSG)-induced obese rats. Unless treated, MSG rats exhibited peripheral insulin resistance, cognitive deficits, and a reduction in the total hippocampal volume with decreased neuron count in the DG, CA3, and CA1 subfields...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29248586/improving-the-diagnosis-of-invasive-aspergillosis-by-the-detection-of-aspergillus-in-broncho-alveolar-lavage-fluid-comparison-of-non-culture-based-assays
#18
Hélène Guegan, Florence Robert-Gangneux, Christophe Camus, Sorya Belaz, Tony Marchand, Marion Baldeyrou, Jean-Pierre Gangneux
OBJECTIVES: This study aimed to evaluate new tools to diagnose invasive aspergillosis (IA) directly from broncho-alveolar lavage (BAL) samples. METHODS: All consecutive patients with suspected IA who underwent bronchoscopy with BAL were prospectively included. Mycological culture and ELISA detection of galactomannan (GM) were performed on BAL. Two in-house and two marketed PCR assays were used on BAL DNA extracts to detect Aspergillus species. Susceptibility testing was performed after culture; marketed PCR assays detected mutations in the CYP51A gene associated to resistance...
December 14, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29227690/effect-of-the-induction-of-transgenerational-obesity-on-maternal-fetal-parameters
#19
Thaigra Sousa Soares, Ana Paula Andreolla, Carolina Abreu Miranda, Eduardo Klöppel, Luhara Silva Rodrigues, Rafaianne Queiroz Moraes-Souza, Débora Cristina Damasceno, Gustavo Tadeu Volpato, Kleber Eduardo Campos
Maternal obesity can cause complications for both women and their offspring for generations. Therefore, we intended to verify the repercussions of induction of transgenerational obesity on biochemical parameters, reproductive performance, and congenital anomaly frequency in Wistar rats. Female rats were used from successive generations. The female rats of parental generation (F0, n=10) were mated to obtain their offspring (F1 generation). F1 female rats received a monosodium glutamate (MSG) solution to induce obesity (n=07) or vehicle (control, n=06) during the neonatal period...
December 11, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29212355/the-utility-of-contrast-enhanced-hypodense-sign-for-the-diagnosis-of-pulmonary-invasive-mold-disease-in-patients-with-haematological-malignancies
#20
Claudia Sassi, Marta Stanzani, Russell E Lewis, Giancarlo Facchini, Alberto Bazzocchi, Michele Cavo, Giuseppe Battista
OBJECTIVE: The hypodense sign (HyS) on CT imaging is highly suggestive of pulmonary invasive mould disease (IMD) in patients with haematological malignancies, but its diagnostic utility has not been systematically evaluated on contrast-enhanced CT. The objective of this study was to compare the diagnostic performance of the HyS to other common CT findings in a cohort of haematology patients with proven, probable or possible IMD based on EORTC/MSG criteria. METHODS: We analyzed the diagnostic performance of the HyS to other common CT signs among 127 neutropenic patients with haematological malignancies submitted to both noncontrast-enhanced and contrast-enhanced CT scans of the lungs, including CT pulmonary angiography (CTPA)...
December 7, 2017: British Journal of Radiology
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