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https://www.readbyqxmd.com/read/27890806/the-endocrine-disrupting-potential-of-monosodium-glutamate-msg-on-secretion-of-the-glucagon-like-peptide-1-glp-1-gut-hormone-and-glp-1-receptor-interaction
#1
Maeve Shannon, Brian Green, Gary Willars, Jodie Wilson, Natalie Matthews, Joanna Lamb, Anna Gillespie, Lisa Connolly
Monosodium glutamate (MSG) is a suspected obesogen with epidemiological evidence positively correlating consumption to increased body mass index and higher prevalence of metabolic syndrome. ELISA and high content analysis (HCA) were employed to examine the disruptive effects of MSG on the secretion of enteroendocrine hormone glucagon-like peptide-1 (GLP-1) and GLP-1 receptor (GLP-1R), respectively. Following 3h MSG exposure of the enteroendocrine pGIP/neo: STC-1 cell line model (500μg/ml) significantly increased GLP-1 secretion (1...
November 24, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27880963/enhanced-production-of-gamma-aminobutyric-acid-by-optimizing-culture-conditions-of-lactobacillus-brevis-hye1-isolated-from-kimchi-a-korean-fermented-food
#2
Hee Seon Lim, In-Tae Cha, Seong Woon Roh, Hae-Hun Shin, Myung-Ji Seo
This study evaluated the effects of culture conditions, including carbon and nitrogen sources, L-monosodium glutamate (MSG), and initial pH, on gamma-aminobutyric acid (GABA) production by Lactobacillus brevis HYE1 isolated from kimchi, a Korean traditional fermented food. L. brevis HYE1 was screened by the production analysis of GABA and genetic analysis of glutamate decarboxylase gene, resulting in 14.64 mM GABA after 48 h of cultivation in MRS media containing 1% (w/v) MSG. In order to increase GABA production by L...
November 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27862370/comparative-evaluation-of-pan-fungal-real-time-pcr-galactomannan-and-1-3-%C3%AE-d-glucan-assay-for-invasive-fungal-infection-in-paediatric-cancer-patients
#3
Prashant Gupta, Abrar Ahmad, Vineeta Khare, Archana Kumar, Gopa Banerjee, Nitya Verma, Mastan Singh
Limited specific data and investigations are available for the diagnosis of Invasive Fungal Infection (IFI) in paediatrics cancer patients. Three non-invasive tests; Platelia Aspergillus EIA for galactomannan (GM), β-D-glucan (BDG) assay and pan-fungal real-time PCR for fungal DNA in blood were evaluated. One hundred twenty-five paediatrics cancer patients at the high risk of IFI were enrolled. Single blood and serum samples were evaluated by all the three methods. Patients were classified into 10 proven, 52 probable and 63 no IFI cases in accordance with EORTC MSG 2008 revised guidelines...
November 16, 2016: Mycoses
https://www.readbyqxmd.com/read/27837506/serological-approaches
#4
Barbora Weinbergerova, Iva Kocmanova, Zdenek Racil, Jiri Mayer
The diagnosis of invasive fungal diseases (IFD) based on clinical, radiological, and conventional microbiological findings is not reliable and is often delayed. Non-culture-based methods with higher sensitivity and specificity may reduce diagnostic time and result in decreased IFD morbidity and mortality. These methods are now increasingly used to manage patients at risk of IFD. Among available biomarkers, fungal antigens have been investigated as an aid to early diagnosis and are predominantly used as screening tests to prompt antifungal treatment mainly in patients with hematological malignancies...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27832295/present-global-situation-of-amino-acids-in-industry
#5
Naoto Tonouchi, Hisao Ito
At present, amino acids are widely produced and utilized industrially. Initially, monosodium glutamate (MSG) was produced by extraction from a gluten hydrolysate. The amino acid industry started using the residual of the lysate. The discovery of the functions of amino acids has led to the expansion of their field of use. In addition to seasoning and other food use, amino acids are used in many fields such as animal nutrients, pharmaceuticals, and cosmetics. On the other hand, the invention of the glutamate fermentation process, followed by the development of fermentation methods for many other amino acids, is no less important...
November 11, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27825986/intracerebroventricular-injection-of-ghrelin-decreases-wheel-running-activity-in-rats
#6
Yumiko Miyatake, Tetsuya Shiuchi, Kazuaki Mawatari, Satomi Toda, Yasuko Taniguchi, Akari Futami, Fukiko Sato, Masashi Kuroda, Mayu Sebe, Rie Tsutsumi, Nagakatsu Harada, Yasuhiko Minokoshi, Tadahiro Kitamura, Koro Gotoh, Masaki Ueno, Yutaka Nakaya, Hiroshi Sakaue
There is an increasing interest in elucidating the molecular mechanisms by which voluntary exercise is regulated. In this study, we examined how the central nervous system regulates exercise. We used SPORTS rats, which were established in our laboratory as a highly voluntary murine exercise model. SPORTS rats showed lower levels of serum ghrelin compared with those of the parental line of Wistar rats. Intracerebroventricular and intraperitoneal injection of ghrelin decreased wheel-running activity in SPORTS rats...
November 5, 2016: Peptides
https://www.readbyqxmd.com/read/27815226/utility-of-the-serum-galactomannan-assay-for-the-diagnosis-of-invasive-aspergillosis-in-children-with-acute-lymphoblastic-leukemia
#7
Gulhadiye Avcu, Deniz Yilmaz Karapinar, Ayse Burcu Akinci, Zuhal Onder Sivis, Akkiz Sahin, Zumrut Sahbudak Bal, Suleyha Hilmioglu Polat, Dilek Yesim Metin, Fadil Vardar, Yesim Aydinok
OBJECTIVES: Invasive aspergillosis (IA) is an important cause of mortality and morbidity in children with hematological malignancies. The monitoring of serum galactomannan (GM) antigen is considered useful in the diagnosis of IA . The aim of this study was to determine the utility of serum GM monitoring in the early diagnosis of IA and the role of positive antigenemia in the management of children with acute lymphoblastic leukemia (ALL). METHODS: The cases of 141 children who were being treated for ALL in the Division of Pediatric Hematology of the Medical School of Ege University between January 2006 and February 2015 were reviewed retrospectively...
November 1, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27795339/prospective-biomarker-screening-for-the-diagnosis-of-invasive-aspergillosis-in-high-risk-paediatric-patients
#8
Juergen Loeffler, Julia Hafner, Carlo Mengoli, Clemens Wirth, Claus Peter Heussel, Claudia Löffler, P Lewis White, Andrew J Ullmann, Denise Michel, Verena Wiegering, Matthias Wölfl, Paul Gerhardt Schlegel, Hermann Einsele, Jan Springer, Matthias Eyrich
Combined biomarker screening is increasingly used to diagnose invasive aspergillosis (IA) in high-risk patients. In adults, the combination of galactomannan (GM) and fungal DNA detection has proven to be beneficial in the diagnosis of IA. Data in purely paediatric cohorts is scarce. Here, we monitored 39 children shortly before and after allogeneic stem cell transplantation twice weekly using a commercial GM ELISA and a PCR assay based on amplification of the pan-Aspergillus ITS1/5.8S ribosomal operon. In addition, clinical data were recorded and classification of IA was performed according to EORTC/MSG criteria...
October 19, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27791369/formation-of-3-mcpd-fatty-acid-esters-from-monostearoyl-glycerol-and-the-thermal-stability-of-3-mcpd-monoesters
#9
Yue Zhao, Yaqiong Zhang, Zhongfei Zhang, Jie Liu, Yi-Lin Wang, Boyan Gao, Yuge Niu, Xiangjun Sun, Liangli Lucy Yu
Formation of 3-monochloropropanediol (3-MCPD) esters from monostearoyl glycerol (MSG) was investigated under a high temperature and low moisture condition. Different organic and inorganic chlorides, including lindane, KCl, CaCl2, NaCl, MgCl2, AlCl3, CuCl2, MnCl2, SnCl2, ZnCl2 and FeCl3, were evaluated for their potential to react with MSG to form 3-MCPD and glycidyl esters at 120 °C and 240 °C using a UPLC-Q-TOF MS analysis. The results indicated that different chlorine compounds differed in their capacity to react with MSG, and formed different products including 3-MCPD mono- and di-esters, distearoyglycerol and glycidyl esters...
October 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27744310/galactomannan-testing-and-aspergillus-pcr-in-same-day-bronchoalveolar-lavage-and-blood-samples-for-diagnosis-of-invasive-aspergillosis
#10
Susanne Eigl, Martin Hoenigl, Birgit Spiess, Sven Heldt, Juergen Prattes, Peter Neumeister, Albert Wolfler, Jasmin Rabensteiner, Florian Prueller, Robert Krause, Mark Reinwald, Holger Flick, Dieter Buchheidt, Tobias Boch
In recent years galactomannan antigen testing (GM) and also Aspergillus PCR have become increasingly important for diagnosis of invasive aspergillosis (IA). Whether or not these tests need to be performed with bronchoalveolar lavage fluid (BALF; i.e., primary site of infection), or testing of blood samples is sufficient, remains, however, a matter of debate. We evaluated the diagnostic performance of GM ELISA, and Aspergillus PCR by using BALF samples and blood samples obtained at the same day from a total of 53 immunocompromised patients (16 with probable/proven IA and 37 with no evidence of IA according to the revised EORTC/MSG criteria; 38 patients with hematological malignancies were prospectively enrolled at the Medical University of Graz, Austria, 15 patients with mixed underlying diseases at the Mannheim University Hospital)...
October 14, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27725383/numerical-evaluation-of-efficacy-of-glutamate-on-gastrointestinal-motility-rapid-mri-study
#11
Shinsuke Nakayama, Hidemi Teramoto
 The umami taste amino acid, glutamate acts as a signaling molecule in multiple cellular systems in the body, including the brain and gastrointestinal tract. Therefore, glutamate may affect appetite by modulating gastrointestinal motility as well as through taste perception. In this study, we examined the effect of glutamate on gastric emptying and duodenal motility, by using rapid magnetic resonance imaging (MRI). Ten healthy male volunteers participated in the measurements. Abdominal coronal MR images were successively acquired after ingestion of a liquid meal with and without monosodium L-glutamate (MSG)...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27714637/headaches-a-review-of-the-role-of-dietary-factors
#12
Zoya Zaeem, Lily Zhou, Esma Dilli
Dietary triggers are commonly reported by patients with a variety of headaches, particularly those with migraines. The presence of any specific dietary trigger in migraine patients varies from 10 to 64 % depending on study population and methodology. Some foods trigger headache within an hour while others develop within 12 h post ingestion. Alcohol (especially red wine and beer), chocolate, caffeine, dairy products such as aged cheese, food preservatives with nitrates and nitrites, monosodium glutamate (MSG), and artificial sweeteners such as aspartame have all been studied as migraine triggers in the past...
November 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27699780/diet-and-headache-part-1
#13
Vincent T Martin, Brinder Vij
BACKGROUND: The role of diet in the management of the headache patient is a controversial topic in the headache field. OBJECTIVES: To review the evidence supporting the hypothesis that specific foods or ingredients within foods and beverages trigger attacks of headache and/or migraine and to discuss the use of elimination diets in the prevention of headache disorders METHODS: This represents part 1 of a narrative review of the role of diet in the prevention of migraine and other headache disorders...
October 2016: Headache
https://www.readbyqxmd.com/read/27660157/probiotics-supplemented-with-omega-3-fatty-acids-are-more-effective-for-hepatic-steatosis-reduction-in-an-animal-model-of-obesity
#14
Nazarii Kobyliak, Tetyana Falalyeyeva, Petro Bodnar, Tetyana Beregova
Today probiotics have been suggested as a treatment for the prevention of NAFLD. Omega-3 fatty acid supplementation may have beneficial effects in regulating hepatic lipid metabolism, adipose tissue function and inflammation. The present study was designed to determine whether probiotics plus omega-3 are superior to probiotics alone on the monosodium glutamate (MSG)-induced NAFLD model in rats. We included 60 rats divided into four groups, 15 animals in each. Rats of group I were intact. Newborn rats of groups II-IV were injected with MSG...
September 22, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27631967/genome-wide-identification-and-analysis-of-jhbp-domain-family-members-in-the-silkworm-bombyx-mori
#15
Wei Li, Tingcai Cheng, Wenbo Hu, Zhangchuan Peng, Chun Liu, Qingyou Xia
Juvenile hormone (JH) regulates the insect growth and development. JH appears in the hemolymph bound by a specific glycoprotein, juvenile hormone-binding protein (JHBP), which serves as a carrier to release the hormone to target tissues and cells. However, JHBP family candidates, expression patterns, and functional implications are still unclear. In this study, we identified 41 genes-containing conserved JHBP domains distributed across eight chromosomes of the silkworm Bombyx mori. A phylogenetic tree showed that the silkworm JHBP (BmJHBP) genes could be classified into two major branches and four subfamilies...
September 8, 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27619810/usage-of-1-3-%C3%AE-d-glucan-for-early-detection-of-invasive-mycoses-and-outcome-parameter-in-immunocompromised-critically-ill-patients
#16
Tobias Lahmer, Jürgen Held, Sebastian Rasch, Christopher Schnappauf, Analena Beitz, Roland M Schmid, Wolfgang Huber
INTRODUCTION: Invasive fungal disease (IFD) remains a significant cause of morbidity and mortality in critically ill patients. METHODS: Examination of 1,3-β-D-glucan (BDG) for IFD and as outcome parameter in immunocompromised critically ill patients with septic shock. RESULTS: Thirty-two (69 %) out of 46 included patients had BDG beyond the cutoff of >80 pg/ml (mean 320 pg/ml). Twelve (37 %) had findings of Aspergillus spp. in BAL (mean BDG 413 pg/ml)...
September 12, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27613139/expression-of-type-iii-interferons-ifn%C3%AE-s-and-their-receptor-in-sj%C3%A3-gren-s-syndrome
#17
E Apostolou, E K Kapsogeorgou, O D Konsta, I Giotakis, M I Saridaki, E Andreakos, A G Tzioufas
Type III interferons (IFNs) or IFN-λs (IFN-λ1/IL29, IFN-λ2/interleukin (IL)-28A and IFN-λ3/IL-28B) consist of a recently identified group of IFNs, implicated initially in several human diseases, including cancer and autoimmunity. In this study, we sought to investigate the expression of type III IFNs and their common receptor IFN-λR1/IL-28Ra in Sjögren's syndrome (SS). Type III IFN expression was examined in minor salivary gland tissues (MSG), peripheral blood mononuclear cells (PBMCs), sera and resting or Toll-like receptor (TLR)-stimulated salivary gland epithelial cells (SGEC) from SS patients and sicca-complaining controls...
December 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27598115/-13-c-nmr-based-metabolomic-profiling-of-typical-asian-soy-sauces
#18
Ghulam Mustafa Kamal, Bin Yuan, Abdullah Ijaz Hussain, Jie Wang, Bin Jiang, Xu Zhang, Maili Liu
It has been a strong consumer interest to choose high quality food products with clear information about their origin and composition. In the present study, a total of 22 Asian soy sauce samples have been analyzed in terms of (13)C-NMR spectroscopy. Spectral data were analyzed by multivariate statistical methods in order to find out the important metabolites causing the discrimination among typical soy sauces from different Asian regions. It was found that significantly higher concentrations of glutamate in Chinese red cooking (CR) soy sauce may be the result of the manual addition of monosodium glutamate (MSG) in the final soy sauce product...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27597864/chronic-glucocorticoid-rich-milieu-and-liver-dysfunction
#19
Hernán Gonzalo Villagarcía, Vanesa Sabugo, María Cecilia Castro, Guillermo Schinella, Daniel Castrogiovanni, Eduardo Spinedi, María Laura Massa, Flavio Francini
We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA)...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27567226/interleukin-15-as-a-potential-new-target-in-sj%C3%A3-gren-s-syndrome-associated-inflammation
#20
Margherita Sisto, Loredana Lorusso, Sabrina Lisi
IL-15 is a key regulatory cytokine that shares many biological properties with IL-2. Recently, it has been shown that IL-15 could be up-regulated in T cell-mediated inflammatory disorders, such as rheumatoid arthritis and inflammatory bowel diseases. However, the role and expression of IL-15 in the inflammatory autoimmune disease Sjögren's syndrome (SS) has not been investigated. In the present study we evaluated the expression of IL-15 mRNA and protein in minor salivary gland (MSG) biopsy specimens and in human salivary gland epithelial cell (SGEC) cultures obtained from patients with primary SS (pSS) and compared their expression with that seen in normal healthy control subjects...
October 2016: Pathology
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