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https://www.readbyqxmd.com/read/28821029/effect-of-gum-arabic-modified-alginate-on-physicochemical-properties-release-kinetics-and-storage-stability-of-liquid-core-hydrogel-beads
#1
Fu-Hsuan Tsai, Yutaka Kitamura, Mito Kokawa
Different weight ratios of alginate/gum arabic (GA) solutions were prepared to serve as the wall material of liquid-core hydrogel beads (LHB) that were formulated to protect the total phenolic compounds (TP) of radish by-product juice from degradation during storage and release in simulated gastrointestinal fluid. The diameter of LHB ranged from 4.63 to 5.66mm with a sphericity lower than 0.05. LHB formulated with 25% GA (AGB0.25) exhibited the highest hardness (26.63N), and those formulated with 50% GA (AGB0...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820987/a-new-label-free-electrochemical-immunosensor-based-on-dendritic-core-shell-aupd-au-nanocrystals-for-highly-sensitive-detection-of-prostate-specific-antigen
#2
Rui Wang, Wei-Dong Liu, Ai-Jun Wang, Yadong Xue, Liang Wu, Jiu-Ju Feng
Herein, bimetallic dendritic core-shell AuPd@Au nanocrystals (AuPd@Au NCs) were prepared by a simple one-pot aqueous method using xanthine as a green growth-directing agent. By virtue of the enhanced peak currents in the H2O2 reduction catalyzed by AuPd@Au NCs, a label-free immunosensor was constructed for the detection of prostate specific antigen (PSA). The immunosensor exhibited significantly improved analytical performance for the assay of PSA with wide linear range of 0.1-50ngmL(-1) and low detection limit of 0...
August 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28820986/an-ultrasensitive-sandwich-type-electrochemical-immunosensor-based-on-the-signal-amplification-strategy-of-echinoidea-shaped-au-ag-cu2o-nanoparticles-for-prostate-specific-antigen-detection
#3
Yuying Yang, Qin Yan, Qing Liu, Yongpeng Li, Hui Liu, Ping Wang, Lei Chen, Daopeng Zhang, Yueyun Li, Yunhui Dong
Highly sensitive determination of tumor markers plays an important role in early diagnosis of cancer. Herein, a novel and ultrasensitive sandwich-type electrochemical immunosensor was fabricated for quantitative detection of prostate specific antigen (PSA). In this process, gold nanoparticles functionalized nitrogen-doped graphene quantum dots (Au@N-GQDs) was synthesized through a simple and green hydrothermal procedure to enhance conductivity, specific electrode surface area and quantity of immobilized primary antibodies (Ab1)...
August 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28820334/evolutionary-analysis-of-a-novel-zinc-ribbon-in-the-n-terminal-region-of-threonine-synthase
#4
Gurmeet Kaur, Srikrishna Subramanian
Threonine synthase (TS) catalyzes the terminal reaction in the biosynthetic pathway of threonine and requires pyridoxal phosphate as a cofactor. TSs share a common catalytic domain with other fold type II PALP dependent enzymes. TSs are broadly grouped into two classes based on their sequence, quaternary structure, and enzyme regulation. We report the presence of a novel zinc ribbon domain in the N-terminal region preceding the catalytic core in TS. The zinc ribbon domain is present in TSs belonging to both classes...
August 18, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28820218/photophysical-characterization-and-time-resolved-spectroscopy-of-a-anthradithiophene-dimer-exploring-the-role-of-conformation-in-singlet-fission
#5
Jacob C Dean, Ruomeng Zhang, Rawad K Hallani, Ryan D Pensack, Samuel N Sanders, Daniel G Oblinsky, Sean R Parkin, Luis M Campos, John E Anthony, Gregory D Scholes
Quantitative singlet fission has been observed for a variety of acene derivatives such as tetracene and pentacene, and efforts to extend the library of singlet fission compounds is of current interest. Preliminary calculations suggest anthradithiophenes exhibit significant exothermicity between the first optically-allowed singlet state, S1, and 2 × T1 with an energy difference of >5000 cm(-1). Given the fulfillment of this ingredient for singlet fission, here we investigate the singlet fission capability of a difluorinated anthradithiophene dimer (2ADT) covalently linked by a (dimethylsilyl)ethane bridge and derivatized by triisobutylsilylethynyl (TIBS) groups...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28819188/highly-stabilized-core-satellite-gold-nanoassemblies-in-vivo-dna-directed-self-assembly-peg-modification-and-cell-imaging
#6
Liangfeng Tang, Guiping Yu, Lishan Tan, Min Li, Xiulong Deng, Jianyu Liu, Aiqing Li, Xuandi Lai, Jianqiang Hu
Au nanoparticles (NPs) have important applications in bioimaging, clinical diagnosis and even therapy due to its water-solubility, easy modification and drug-loaded capability, however, easy aggregation of Au NPs in normal saline and serum greatly limits its applications. In this work, highly stabilized core-satellite Au nanoassemblies (CSAuNAs) were constructed by a hierarchical DNA-directed self-assembly strategy, in which satellite Au NPs number could be effectively tuned through varying the ratios of core-AuNPs-ssDNA and satellite-AuNPs-ssDNAc...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819128/porous-polystyrene-monoliths-and-microparticles-prepared-from-core-cross-linked-star-ccs-polymers-stabilized-emulsions
#7
Qijing Chen, Ting Shi, Fei Han, Zihan Li, Chao Lin, Peng Zhao
A hydrophobic CCS polymer of poly(benzyl methacrylate) (PBzMA) was prepared in toluene by reversible addition-fragmentation chain transfer (RAFT)-mediated dispersion polymerization. The CCS polymer, with poly(benzyl methacrylate) as the arm and crosslinked N, N'-bis(acryloyl)cystamine (BAC) as the core, was confirmed by characterization with gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR) spectroscopy. Three kinds of oils (toluene, anisole and styrene) were chosen to study the emulsification properties of PBzMA CCS polymer...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818703/traceable-peo-poly-ester-micelles-for-breast-cancer-targeting-the%C3%A2-effect-of-core-structure-and-targeting-peptide-on-micellar-tumor%C3%A2-accumulation
#8
Shyam M Garg, Igor M Paiva, Mohammad R Vakili, Rania Soudy, Kate Agopsowicz, Amir H Soleimani, Mary Hitt, Kamaljit Kaur, Afsaneh Lavasanifar
Traceable poly(ethylene oxide)-poly(ester) micelles were developed through chemical conjugation of a near-infrared (NIR) dye to the poly(ester) end by click chemistry. This strategy was tried for micelles with poly(ε-caprolactone) (PCL) or poly(α-benzyl carboxylate-ε-caprolactone) (PBCL) cores. The surface of both micelles was also modified with the breast cancer targeting peptide, P18-4. The results showed the positive contribution of PBCL over PCL core on micellar thermodynamic and kinetic stability as well as accumulation in primary orthotopic MDA-MB-231 tumors within 4-96 h following intravenous administration in mice...
August 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28817251/dual-core-shell-structured-s-c-mno2-nanocomposite-for-highly-stable-lithium-sulfur-batteries
#9
Lubin Ni, Gangjin Zhao, Guang Yang, Guosheng Niu, Ming Chen, Guowang Diao
Lithium-sulfur (Li-S) batteries have currently excited worldwide academic and industrial interest as a next-generation high-power energy storage system (EES) because of their high energy density and low cost of sulfur. However, the commercialization application is being hindered by capacity decay, mainly attributed to the polysulfide shuttle and poor conductivity of sulfur. Here, we have designed a novel dual core-shell nanostructure of S@C@MnO2 nanosphere hybrid as the sulfur host. The S@C@MnO2 nanosphere is successfully prepared using mesoporous hollow carbon spheres (MHCS) as the template and then in situ MnO2 growth on the surface of MHCS...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28817146/controlled-deposition-of-palladium-nanodendrites-on-the-tips-of-gold-nanorods-and-their-enhanced-catalytic-activity
#10
Gaoxing Su, Huaqiao Jiang, Hongyan Zhu, Jing-Jing Lv, Guohai Yang, Bing Yan, Jun-Jie Zhu
Plasmonic Au-Pd nanostructures have drawn significant attention for use in heterogeneous catalysis. In this study, palladium nanodendrite-tipped gold nanorods (PdND-T-AuNRs) were subjected to a facile fabrication under mild reaction conditions. The palladium amounts on the two tips were tunable. In the preparation of PdND-T-AuNRs, dense capped AuNRs, a low reaction temperature, and suitable stabilizing agents were identified as critical reaction parameters for controlling palladium nanodendrites deposited on both ends of AuNRs...
August 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28816400/silica-modified-luminescent-lapo4-eu-lapo4-sio2-core-shell-nanorods-synthesis-structural-and-luminescent-properties
#11
Anees A Ansari
Monoclinic-type tetragonal LaPO4 :Eu (core) and LaPO4 :Eu@LaPO4 (core/shell) nanorods (NRs) were successfully prepared using a urea-based co-precipitation process under ambient conditions. An amorphous silica layer was coated around the luminescent core/shell NRs via the sol-gel process to improve their solubility and colloidal stability in aqueous and non-aqueous media. The prepared nano-products were systematically characterized by X-ray diffraction pattern, transmission electron microscopy, energy dispersive X-ray analysis, and FTIR, UV/Vis, and photoluminescence spectroscopy to examine their phase purity, crystal phase, surface chemistry, solubility and luminescence characteristics...
August 17, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28816322/ultrasonication-enhanced-gelation-properties-of-a-versatile-amphiphilic-formamidine-based-gelator-exhibiting-both-organogelation-and-hydrogelation-abilities
#12
Jürgen Bachl, Diego Sampedro, Judith Mayr, David Díaz Díaz
We describe the preparation of a novel amphiphilic gelator built from a formamidine core, which is able to form a variety of physical organogels and hydrogels at concentrations ranging from 15 to 150 mg mL(-1). Interestingly, ultrasound treatment of isotropic solutions (i.e., gel-precursor) resulted in a remarkable enhancement of the gelation kinetics as well as the gelation scope and characteristic gel properties (e.g., critical gelation concentration, gel-to-sol transition temperature, viscoelastic moduli) in comparison to the heating-cooling protocol typically used to obtain supramolecular gels...
August 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28816320/formation-of-titanium-dioxide-core-shell-microcapsules-through-a-binary-phase-spray-technique
#13
Jonatan Bergek, Björn Elgh, Anders E C Palmqvist, Lars Nordstierna
Core-shell microcapsules consisting of a titanium dioxide shell and a hydrophobic solvent core have been prepared with diameters of a few micrometers and a narrow size distribution using a simple and fast airbrush technique. These microcapsules were prepared at room temperature in a single-step process in which an oil with a dissolved titanium alkoxide precursor was forced together with an aqueous solution, containing a surface-active polymer, through a narrow spray nozzle using a nitrogen gas propellant. Several different parameters of chemical, physical, and processing origin were investigated to find an optimal recipe...
August 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28816318/a-soluble-star-shaped-silsesquioxane-cored-polymer-towards-novel-stabilization-of-ph-dependent-high-internal-phase-emulsions
#14
Yuxiu Xing, Jun Peng, Kai Xu, Shuxi Gao, Xuefeng Gui, Shengyuan Liang, Longfeng Sun, Mingcai Chen
A well-defined pH-responsive star-shaped polymer containing poly(N,N-dimethylaminoethyl methacrylate) (PDMA) arms and a cage-like methacryloxypropyl silsesquioxane (CMSQ-T10) core was used as an interfacial stabilizer for emulsions consisting of m-xylene and water. We explored the properties of the CMSQ/PDMA star-shaped polymer using the characteristic results of nuclear magnetic resonance (NMR) spectroscopy, size exclusion chromatography (SEC), dynamic light scattering (DLS), and zeta potential and conductivity measurements...
August 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28816042/rapid-and-reliable-detection-of-alkaline-phosphatase-by-a-hot-spots-amplification-strategy-based-on-well-controlled-assembly-on-single-nanoparticle
#15
Yi Zeng, Jia-Qiang Ren, Shaokai Wang, Jiaming Mai, Bing Qu, Yan Zhang, Ai-Guo Shen, Jiming Hu
The first appeal of clinical assay is always accurate and rapid. For alkaline phosphatase (ALP) monitoring in medical treatment, a rapid, reliable surface-enhanced Raman scattering (SERS) test kit is designed based on a "hot spots" amplification strategy. Consisting of alkyne-tagged Au nanoparticles (NPs), Ag+, and enzyme substrate, the packaged test kit can achieve one-step clinical assay of ALP in human serum within several minutes, while the operation is simple as it directly inputs the sample into the test kit...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28815732/antibacterial-and-%C3%AE-lactamase-inhibitory-activity-of-monocyclic-%C3%AE-lactams
#16
REVIEW
Lena Decuyper, Marko Jukič, Izidor Sosič, Aleš Žula, Matthias D'hooghe, Stanislav Gobec
Due to the widespread emergence of resistant bacterial strains, an urgent need for the development of new antibacterial agents with novel modes of action has emerged. The discovery of naturally occurring monocyclic β-lactams in the late 1970s, mainly active against aerobic Gram-negative bacteria, has introduced a new approach in the design and development of novel antibacterial β-lactam agents. The main goal was the derivatization of the azetidin-2-one core in order to improve their antibacterial potency, broaden their spectrum of activity, and enhance their β-lactamase stability...
August 16, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28814505/the-molecular-architecture-of-the-yeast-spindle-pole-body-core-determined-by-bayesian-integrative-modeling
#17
Shruthi Viswanath, Massimiliano Bonomi, Seung Joong Kim, Vadim A Klenchin, Keenan C Taylor, King C Yabut, Neil T Umbreit, Heather A Van Epps, Janet Meehl, Michele H Jones, Daniel Russel, Javier A Velazquez-Muriel, Mark Winey, Ivan Rayment, Trisha N Davis, Andrej Sali, Eric G Muller
Microtubule organizing centers (MTOCs) form, anchor and stabilize the polarized network of microtubules in a cell. The central MTOC is the centrosome that duplicates during the cell cycle and during mitosis assembles a bipolar spindle to capture and segregate sister chromatids. Yet, despite their importance in cell biology, the physical structure of MTOCs is poorly understood. Here we determine the molecular architecture of the core of the yeast spindle pole body (SPB) by Bayesian integrative structure modeling based on in vivo FRET, small-angle X-ray scattering (SAXS), X-ray crystallography, electron microscopy and two-hybrid analysis...
August 16, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28812872/effect-of-mineral-dissolution-precipitation-and-co2-exsolution-on-co2-transport-in-geological-carbon-storage
#18
Ruina Xu, Rong Li, Jin Ma, Di He, Peixue Jiang
Geological carbon sequestration (GCS) in deep saline aquifers is an effective means for storing carbon dioxide to address global climate change. As the time after injection increases, the safety of storage increases as the CO2 transforms from a separate phase to CO2(aq) and HCO3(-) by dissolution and then to carbonates by mineral dissolution. However, subsequent depressurization could lead to dissolved CO2(aq) escaping from the formation water and creating a new separate phase which may reduce the GCS system safety...
August 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28812069/the-sensitivity-of-folding-free-energy-landscapes-of-trpzips-to-mutations-in-the-hydrophobic-core
#19
Madhulika Gupta, Prabir Khatua, Charusita Chakravarty, Sanjoy Bandyopadhyay
The sensitivity of the stability of folded states and free energy landscapes to the differences in the hydrophobic content of the core residues has been studied for the set of 16-residue trpzips, namely, Trpzip4, Trpzip5 and Trpzip6. The combination of principal component analysis and different secondary structure order metrics as reaction coordinates has been used to characterize and identify all the underlying attractive basins corresponding to the folded and the unfolded states for each trpzip at 300 K. Our results reveal that even a single mutation in the hydrophobic core perturbs the stability of the folded peptide and the conformational preferences for the partially folded and unfolded states significantly, leading to concomitant alterations in the free energy landscape of trpzips...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28811784/does-the-effectiveness-of-core-stability-exercises-correlate-with-the-severity-of-spinal-stenosis-in-patients-with-lumbar-spinal-stenosis
#20
Chaxiang Chen, Zhichao Lin, Yingjie Zhang, Zemin Chen, Shujie Tang
OBJECTIVE: To determine whether the effectiveness of core stability exercises correlates with the severity of spinal stenosis in patients with degenerative lumbar spinal stenosis. METHODS: Forty-two patients with degenerative lumbar spinal stenosis treated in the department of orthopedics of our hospital between May 2013 and January 2016 were included in the study. All the patients performed core stability exercises once daily for six weeks, and the clinical outcomes were evaluated using Japanese Orthopaedic Association (JOA) score and self-reported walking capacity...
May 2017: Pakistan Journal of Medical Sciences Quarterly
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