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Core stability

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https://www.readbyqxmd.com/read/28212487/interactions-between-membranes-and-metaphilic-polypeptide-architectures-with-diverse-sidechain-populations
#1
Michelle W Lee, Ming Han, Guilherme Volpe Bossa, Carly Snell, Ziyuan Song, Haoyu Tang, Lichen Yin, Jianjun Cheng, Sylvio May, Erik Luijten, Gerard C L Wong
At physiological conditions, most proteins or peptides can fold into relatively stable structures that present on their molecular surfaces specific chemical patterns partially smeared out by thermal fluctuations. These nanoscopically defined patterns of charge, hydrogen bonding, and/or hydrophobicity, along with their elasticity and shape stability (folded proteins have Young's moduli of ~1 × 10(8) Pa), largely determine and limit the interactions of these molecules, such as molecular recognition and allosteric regulation...
February 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28212023/electrostatic-assembly-of-functional-and-macromolecular-ferricinium-chloride-stabilized-gold-nanoparticles
#2
Roberto Ciganda, Haibin Gu, Ricardo Hernandez, Ane Escobar, Angel Martínez, Luis Yates, Sergio Moya, Jaime Ruiz, Didier Astruc
Substituted ferrocenes with various stereoelectronic effects including a ferrocene-terminated dendrimer in ether reduce aqueous HAuCl4 to gold nanoparticles (AuNPs) by interfacial electron transfer. The dependence on the stirring speed plays a crucial role, and the stereoelectronic influences on the reaction rates are dramatic. With a ferrocene-containing polymer, the reaction is conducted using an homogeneous THF/water medium, also forming AuNPs. Fully stable functional, dendritic and polymeric ferricinium chloride-stabilized AuNPs are obtained with core sizes between 13 and 35 nm, an optimal size range for potential biomedical applications...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28208990/swiss-ball-versus-mat-exercises-for-core-activation-of-transverse-abdominis-in-recreational-athletes
#3
Prateek Srivastav, Nirmala Nayak, Sudeep Nair, Lobsang Bhuti Sherpa, Diana Dsouza
INTRODUCTION: Core stability is an essential component for improving athletic performance and injury prevention. Exercises on a Swiss ball and on the mat are two different ways of improving core stability. Comparison of these methods can help physiotherapists incorporate the better method for athletic training and rehabilitation. AIM: To compare swiss ball and mat exercises for core stability of transverse abdominis in recreational athletes. MATERIALS AND METHODS: This pilot randomized control trial was performed on a total of 25 recreational athletes...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207779/self-organized-synchronization-of-digital-phase-locked-loops-with-delayed-coupling-in-theory-and-experiment
#4
Lucas Wetzel, David J Jörg, Alexandros Pollakis, Wolfgang Rave, Gerhard Fettweis, Frank Jülicher
Self-organized synchronization occurs in a variety of natural and technical systems but has so far only attracted limited attention as an engineering principle. In distributed electronic systems, such as antenna arrays and multi-core processors, a common time reference is key to coordinate signal transmission and processing. Here we show how the self-organized synchronization of mutually coupled digital phase-locked loops (DPLLs) can provide robust clocking in large-scale systems. We develop a nonlinear phase description of individual and coupled DPLLs that takes into account filter impulse responses and delayed signal transmission...
2017: PloS One
https://www.readbyqxmd.com/read/28207270/intracellular-delivery-colloidally-stable-core-crosslinked-triblock-copolymer-micelles-with-glutathione-responsive-enhanced-drug-release-for-cancer-therapy
#5
Jung Kwon Oh, Depannita Biswas, So Young An, Yijing Li, Xiangtao Wang
Design and development of amphiphilic block copolymer-based nanocarriers exhibiting enhanced colloidal stability upon dilution in the blood and cellular glutathione-responsive rapid drug release is highly desired for tumor-targeting chemotherapy. Herein, we report a novel ABA-type triblock copolymer consisting of a hydrophilic central poly(ethylene glycol) block and two terminal hydrophobic blocks of a polymethacrylate having pendant disulfides (PHMssEt), thus PHMssEt-b-PEG-b-PHMssEt (ssTP). Aqueous self-assembly and following disulfide-exchange reaction of the resulting ssTP allows for formation of core-crosslinked micelles (CCMs) through the formation of new disulfide linkages, retaining enhanced colloidal stability in physiological condition and in the presence of proteins...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28207240/interfaces-in-heterogeneous-catalysts-advancing-mechanistic-understanding-through-atomic-scale-measurements
#6
Wenpei Gao, Zachary D Hood, Miaofang Chi
Developing novel catalysts with high efficiency and selectivity is critical for enabling future clean energy conversion technologies. Interfaces in catalyst systems have long been considered the most critical factor in controlling catalytic reaction mechanisms. Interfaces include not only the catalyst surface but also interfaces within catalyst particles and those formed by constructing heterogeneous catalysts. The atomic and electronic structures of catalytic surfaces govern the kinetics of binding and release of reactant molecules from surface atoms...
February 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28207024/-ru-co-x-core-complexes-with-benzimidazole-ligands-synthesis-x-ray-structure-and-evaluation-of-anticancer-activity-in-vivo
#7
Gabriella Tamasi, Antonello Merlino, Federica Scaletti, Petra Heffeter, Anton A Legin, Michael A Jakupec, Walter Berger, Luigi Messori, Bernhard K Keppler, Renzo Cini
The reaction of [Ru(CO)6Cl2], 1, with N[combining low line](3)-methylbenzimidazole (MBI) and 5,6-dimethylbenzimidazole (DMBI) afforded two new complexes with the general formula fac-[Ru(II)(CO)3Cl2L], L = MBI (2) or DMBI (4). Crystals of cis,trans-[Ru(II)(CO)2Cl2(N[combining low line](3)-MBI)2], 3, were also obtained from the mother liquor that produced 2. In the presence of water, the dissociation of Ru-N, Ru-Cl and Ru-CO bonds occurred as a function of time, water content and pH. Density functional theory structure simulations/optimizations were carried out at the Becke3LYP level of theory for evaluating the relative stability of possible conformers...
February 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28202922/removal-of-silver-nanoparticles-by-mussel-inspired-fe3o4-polydopamine-core-shell-microspheres-and-its-use-as-efficient-catalyst-for-methylene-blue-reduction
#8
Maoling Wu, Yinying Li, Rui Yue, Xiaodan Zhang, Yuming Huang
The removal of silver nanoparticles (AgNPs) from water is highly needed because of their increasing use and potential risk to the environment due to their toxic effects. Catalysis over AgNPs has received significant attention because of their highly catalytic performance. However, their use in practical applications is limited due to high cost and limited resources. Here, we present for the first time that the mussel-inspired Fe3O4@polydopamine (Fe3O4@PDA) nanocomposite can be used for efficient removal and recovery of AgNPs...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28201890/structure-property-relationships-in-cubic-cuprous-iodide-a-novel-view-on-stability-chemical-bonding-and-electronic-properties
#9
A Pishtshev, S Zh Karazhanov
Based on the combination of density functional theory and theory-group methods, we performed systematic modeling of γ-CuI structural design at the atomistic level. Being started from the metallic copper lattice, we treated a crystal assembly as a stepwise iodination process characterized in terms of a sequence of intermediate lattice geometries. These geometries were selected and validated via screening of possible structural transformations. The genesis of chemical bonding was studied for three structural transformations by analyzing the relevant changes in the topology of valence electron densities...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28195374/development-of-polar-order-by-liquid-crystal-self-assembly-of-weakly-bent-molecules
#10
Mohamed Alaasar, Marko Prehm, Silvio Poppe, Carsten Tschierske
Organic ferroelectrics are of growing importance for multifunctional materials. Here we provide an understanding of the distinct stages of the development of sterically induced polar order in liquid crystalline (LC) soft matter. Three series of weakly bent molecules derived from 4-cyanoresorcinol as the bent core unit with laterally fluorinated azobenzene wings have been synthesized and the effects of the position of fluorine substitution, alkyl chain length and temperature on the LC self-assembly and polar order were studied...
February 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28193869/perplexing-cooperative-folding-and-stability-of-a-low-sequence-complexity-polyproline-2-protein-lacking-a-hydrophobic-core
#11
Zachary P Gates, Michael C Baxa, Wookyung Yu, Joshua A Riback, Hui Li, Benoît Roux, Stephen B H Kent, Tobin R Sosnick
The burial of hydrophobic side chains in a protein core generally is thought to be the major ingredient for stable, cooperative folding. Here, we show that, for the snow flea antifreeze protein (sfAFP), stability and cooperativity can occur without a hydrophobic core, and without α-helices or β-sheets. sfAFP has low sequence complexity with 46% glycine and an interior filled only with backbone H-bonds between six polyproline 2 (PP2) helices. However, the protein folds in a kinetically two-state manner and is moderately stable at room temperature...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193044/engineered-iro2-nio-core-shell-nanowires-for-sensitive-non-enzymatic-detection-of-trace-glucose-in-saliva
#12
Junjun Wang, Lin Xu, Yang Lu, Kuang Sheng, Wei Liu, Cong Chen, Yang Li, Biao Dong, Hongwei Song
Hierarchical core-shell IrO2@NiO nanowires (NWs) have been designed through two simple steps, which combined electrospinning of IrO2 conductive core and chemical bath deposition growth of ultracontinuous NiO nanoflakes. Scanning electron microscopy, transmission electron microscopy, X-ray diffraction, energy-dispersive X-ray spectrometry mapping, and X-ray photoelectron spectroscopy were employed to characterize the morphologies and structures of the as-prepared samples, and the results were also carefully compared with that of pure NiO nanoflowers and IrO2 NWs...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192671/electron-deficient-dihydroindaceno-dithiophene-regioisomers-for-n-type-organic-field-effect-transistors
#13
Jean-David Peltier, Benoît Heinrich, Bertrand Donnio, Joëlle Rault-Berthelot, Emmanuel Jacques, Cyril Poriel
In this work, we wish to report the first member of a new family of organic semi-conductors constructed on a meta dihydroindacenodithiophene core, that is 2,2'-(2,8-dihexyl-4,6-dihydro-s-in-da¬ceno[1,2-b:7,6-b']¬dithiophene-4,6-diylidene)dimalononitrile (called meta-IDT(=C(CN)2)2). The properties of this molecule have been studied in detail through a struc¬tu¬re properties relationship study with its regioisomer, that is 2,2'-(2,7-dihexyl-4,9-dihy¬dro-s-indaceno[1,2-b:5,6-b']dithiophene-4,9-diylidene)dimalononitrile (para-IDT(=C(CN)2)2) (see isomers structures in blue in Chart 2)...
February 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28192659/self-host-blue-dendrimer-comprised-of-thermally-activated-delayed-fluorescence-core-and-bipolar-dendrons-for-efficient-solution-processible-nondoped-electroluminescence
#14
Xinxin Ban, Wei Jiang, Kaiyong Sun, Baoping Lin, Yueming Sun
A self-host thermally activated delayed fluorescence (TADF) dendrimer POCz-DPS for solution-processed nondoped blue organic light-emitting diodes (OLEDs) was designed and synthesized, in which the bipolar phosphine oxide carbazole moiety was introduced by alkyl chain to ensure the balanced charge transfer. The investigation of physical properties showed that the bipolar dendrons not only improve the morphological stability, but also restrain the concentration quenching effect of the TADF emissive core. The spin-coated OLEDs featuring POCz-DPS as the host-free blue emitter achieved the highest external quantum efficiency (7...
February 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28192421/g1-cyclins-link-proliferation-pluripotency-and-differentiation-of-embryonic-stem-cells
#15
Lijun Liu, Wojciech Michowski, Hiroyuki Inuzuka, Kouhei Shimizu, Naoe Taira Nihira, Joel M Chick, Na Li, Yan Geng, Alice Y Meng, Alban Ordureau, Aleksandra Kołodziejczyk, Keith L Ligon, Roderick T Bronson, Kornelia Polyak, J Wade Harper, Steven P Gygi, Wenyi Wei, Piotr Sicinski
Progression of mammalian cells through the G1 and S phases of the cell cycle is driven by the D-type and E-type cyclins. According to the current models, at least one of these cyclin families must be present to allow cell proliferation. Here, we show that several cell types can proliferate in the absence of all G1 cyclins. However, following ablation of G1 cyclins, embryonic stem (ES) cells attenuated their pluripotent characteristics, with the majority of cells acquiring the trophectodermal cell fate. We established that G1 cyclins, together with their associated cyclin-dependent kinases (CDKs), phosphorylate and stabilize the core pluripotency factors Nanog, Sox2 and Oct4...
February 13, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28192389/synthesis-and-characterization-of-triangulene
#16
Niko Pavliček, Anish Mistry, Zsolt Majzik, Nikolaj Moll, Gerhard Meyer, David J Fox, Leo Gross
Triangulene, the smallest triplet-ground-state polybenzenoid (also known as Clar's hydrocarbon), has been an enigmatic molecule ever since its existence was first hypothesized. Despite containing an even number of carbons (22, in six fused benzene rings), it is not possible to draw Kekulé-style resonant structures for the whole molecule: any attempt results in two unpaired valence electrons. Synthesis and characterization of unsubstituted triangulene has not been achieved because of its extreme reactivity, although the addition of substituents has allowed the stabilization and synthesis of the triangulene core and verification of the triplet ground state via electron paramagnetic resonance measurements...
February 13, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28191928/self-assembling-multidomain-peptide-nanofibers-for-delivery-of-bioactive-molecules-and-tissue-regeneration
#17
Amanda N Moore, Jeffrey D Hartgerink
Multidomain peptides (MDPs) are a class of self-assembling peptides that are organized in a β-sheet motif, resulting in a nanofibrous architecture. This structure is stabilized by hydrophobic packing in the fiber core and a hydrogen-bonding network down the fiber long axis. Under easily controllable conditions, regulated by electrostatic interactions between the peptides and the pH and salt composition of the solvent, the nanofiber length can be dramatically extended, resulting in fiber entanglement and hydrogel formation...
February 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28191894/open-ringed-structure-of-the-cdt1-mcm2-7-complex-as-a-precursor-of-the-mcm-double-hexamer
#18
Yuanliang Zhai, Erchao Cheng, Hao Wu, Ningning Li, Philip Yuk Kwong Yung, Ning Gao, Bik-Kwoon Tye
The minichromosome maintenance complex (MCM) hexameric complex (Mcm2-7) forms the core of the eukaryotic replicative helicase. During G1 phase, two Cdt1-Mcm2-7 heptamers are loaded onto each replication origin by the origin-recognition complex (ORC) and Cdc6 to form an inactive MCM double hexamer (DH), but the detailed loading mechanism remains unclear. Here we examine the structures of the yeast MCM hexamer and Cdt1-MCM heptamer from Saccharomyces cerevisiae. Both complexes form left-handed coil structures with a 10-15-Å gap between Mcm5 and Mcm2, and a central channel that is occluded by the C-terminal domain winged-helix motif of Mcm5...
February 13, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28188690/interconnected-network-of-shell-core-co-bi-pi-cop-for-efficient-water-oxidation-electrocatalysis-under-near-neutral-conditions
#19
Xuping Sun
Developing earth-abundant electrocatalysts for efficient and stable water oxidation under near neutral conditions is of great importance but still remains a key challenge. In this Communication, we demonstrate the development of an interconnected network of shell-core Co-Bi-Pi@CoP via anodic polarization of CoP nanoarray in potassium borate aqueous electrolyte (KBi). This 3D Co-Bi-Pi@CoP exhibits super high catalytic activity for water oxidation at pH 9.2 and needs overpotential of only 410 mV to drive a geometrical catalytic current density of 10 mA cm-2, with a high turnover frequency of 819 h-1 at overpotential of 610 mV...
February 11, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28187866/the-effects-of-statin-therapy-on-carotid-plaque-composition-and-volume-a-systematic-review-and-meta-analysis
#20
Waleed Brinjikji, Vance T Lehman, David F Kallmes, Alejandro A Rabinstein, Giuseppe Lanzino, Hassan M Murad, Sharon Mulvagh, James Klaas, Jonathan Graff-Radford, Kevin J DeMarco, John Huston Iii
BACKGROUND AND PURPOSE: Prior studies have demonstrated that statin use stabilizes and diminishes atherosclerotic lesions. The main objective of this systematic review and meta-analysis was to study the effects of statin therapy on carotid plaque composition as seen on serial high-resolution carotid plaque MRI. We hypothesized that statin therapy would result in significant improvements in lipid-rich-necrotic-core (LRNC) volumes, wall volumes and lumen volumes. MATERIALS AND METHODS: Prospective studies using serial high-resolution carotid plaque MRI (1...
February 7, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
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