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https://www.readbyqxmd.com/read/28646767/enhanced-photodegradation-of-2-4-dichlorophenoxyacetic-acid-using-a-novel-tio2-mgfe2o4-core-shell-structure
#1
Bui The Huy, Da-Som Jung, Nguyen Thi Kim Phuong, Yong-Ill Lee
A novel TiO2@MgO-Fe2O3 core-shell structure has been synthesized via a hydrolysis and co-precipitation method followed by calcination at 500 °C and has proven to be an efficient photocatalyst. The obtained TiO2@MgO-Fe2O3 core-shell was characterized by scanning electron microscopy, X-ray diffraction, and UV-Vis diffused reflectance techniques. Its photocatalytic activity toward 2,4-dichlorophenoxyacetic acid (2,4-D) was investigated in aqueous solutions with and without visible light irradiation in the presence and absence of hydrogen peroxide...
June 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28644612/suppressing-isomerization-of-phosphine-protected-au9-cluster-by-bond-stiffening-induced-by-a-single-pd-atom-substitution
#2
Seiji Yamazoe, Shota Matsuo, Satoru Muramatsu, Shinjiro Takano, Kiyofumi Nitta, Tatsuya Tsukuda
The fluxional nature of small gold clusters has been exemplified by reversible isomerization between [Au9(PPh3)8](3+) with a crown motif (Au9(C)) and that with a butterfly motif (Au9(B)) induced by association and dissociation with compact counteranions (NO3(-), Cl(-)). However, structural isomerization was suppressed by substitution of the central Au atom of the Au9 core in [Au9(PPh3)8](3+) with a Pd atom: [PdAu8(PPh3)8](2+) with a crown motif (PdAu8(C)) did not isomerize to that with a butterfly motif (PdAu8(B)) upon association with the counteranions...
June 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28643574/stability-and-in-vitro-release-behaviour-of-encapsulated-omega-fatty-acid-rich-oils-in-lentil-protein-isolate-based-microcapsules
#3
C Chang, M T Nickerson
The objective of this study was to investigate the use of a lentil protein isolate-based microcapsule design as a platform for entrapping different types of omega fatty acid-rich oil (e.g. canola, fish and flaxseed oils) and to characterise differences in the physical properties (e.g. moisture content, water activity, colour, wettability, particle size, surface oil and entrapment efficiency), storage stability and in vitro release behaviour of the entrapped oils. All microcapsules displayed similar physical properties regardless of the core material...
June 23, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28643222/ridge-preservation-using-an-in-situ-hardening-biphasic-calcium-phosphate-%C3%AE-tcp-ha-bone-graft-substitute-a-clinical-radiological-and-histological-study
#4
Ashish Kakar, Bappanadu H Sripathi Rao, Shashikanth Hegde, Nikhil Deshpande, Annette Lindner, Heiner Nagursky, Aditya Patney, Harsh Mahajan
BACKGROUND: Post-Extraction ridge preservation using bone graft substitutes is a conservative technique to maintain the width of the alveolar ridge. The objective of the present study was to evaluate an in situ hardening biphasic (HA/β-TCP) bone graft substitutes for ridge preservation without primary wound closure or a dental membrane. METHODS: A total of 15 patients reported for tooth extraction were enrolled in this study. Implants were placed in average 5.2 ± 2 months after socket grafting...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28642482/moving-bragg-grating-solitons-in-a-semilinear-dual-core-system-with-dispersive-reflectivity
#5
S A M Saddam Chowdhury, Javid Atai
The existence, stability and collision dynamics of moving Bragg grating solitons in a semilinear dual-core system where one core has the Kerr nonlinearity and is equipped with a Bragg grating with dispersive reflectivity, and the other core is linear are investigated. It is found that moving soliton solutions exist as a continuous family of solutions in the upper and lower gaps of the system's linear spectrum. The stability of the moving solitons are investigated by means of systematic numerical stability analysis, and the effect and interplay of various parameters on soliton stability are analyzed...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642033/atg4b-inhibitors-with-a-benzotropolone-core-structure-block-autophagy-and-augment-efficiency-of-chemotherapy-in-mice
#6
Ammar Kurdi, Matthias Cleenewerck, Christel Vangestel, Sophie Lyssens, Wim Declercq, Jean-Pierre Timmermans, Sigrid Stroobants, Koen Augustyns, Guido R Y De Meyer, Pieter Van Der Veken, Wim Martinet
Autophagy is a cell survival mechanism hijacked by advanced tumors to endure a rough microenvironment. Late autophagy inhibitors such as (hydroxy)chloroquine have been used clinically to halt tumor progression with modest success. However, given the toxic nature of these compounds and their lack of specificity, novel targets should be considered. We recently identified a benzotropolone derivative that significantly inhibited the essential autophagy protein ATG4B. Therefore, we synthesized and tested additional benzotropolone compounds to identify a promising ATG4B inhibitor that impairs autophagy both in vitro and in vivo...
June 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28641088/application-of-zeolite-hydrous-zirconia-composite-as-a-novel-sediment-capping-material-to-immobilize-phosphorus
#7
Yi Fan, Yiwen Li, Deyi Wu, Chunjie Li, Hainan Kong
A unique sediment-capping agent consisting of a zeolite/hydrous zirconia composite (ZHZ) was developed and tested for P-immobilization in the overlying water and sediment cores from a freshwater pond. In the ZHZ, NaP1 zeolite was covered with hydrous zirconia, which existed as an amorphous phase. Experimental results in pond water indicated that ZHZ could efficiently remove soluble reactive phosphorus. The 28-day sediment incubation experiments showed that capping sediment with ZHZ resulted in a more efficient, rapid and sustained decrease in P concentration when compared with the traditional alum treatment method...
June 12, 2017: Water Research
https://www.readbyqxmd.com/read/28638591/replicable-in-vivo-physiological-and-behavioral-phenotypes-of-the-shank3b-null-mutant-mouse-model-of-autism
#8
Sameer C Dhamne, Jill L Silverman, Chloe E Super, Stephen H T Lammers, Mustafa Q Hameed, Meera E Modi, Nycole A Copping, Michael C Pride, Daniel G Smith, Alexander Rotenberg, Jacqueline N Crawley, Mustafa Sahin
BACKGROUND: Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral abnormalities. No treatments are approved for the core diagnostic symptoms of ASD. To enable the earliest stages of therapeutic discovery and development for ASD, robust and reproducible behavioral phenotypes and biological markers are essential to establish in preclinical animal models. The goal of this study was to identify electroencephalographic (EEG) and behavioral phenotypes that are replicable between independent cohorts in a mouse model of ASD...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28638177/highly-luminescent-water-dispersible-nir-emitting-wurtzite-cuins2-zns-core-shell-colloidal-quantum-dots
#9
Chenghui Xia, Johannes D Meeldijk, Hans C Gerritsen, Celso de Mello Donega
Copper indium sulfide (CIS) quantum dots (QDs) are attractive as labels for biomedical imaging, since they have large absorption coefficients across a broad spectral range, size- and composition-tunable photoluminescence from the visible to the near-infrared, and low toxicity. However, the application of NIR-emitting CIS QDs is still hindered by large size and shape dispersions and low photoluminescence quantum yields (PLQYs). In this work, we develop an efficient pathway to synthesize highly luminescent NIR-emitting wurtzite CIS/ZnS QDs, starting from template Cu2-x S nanocrystals (NCs), which are converted by topotactic partial Cu(+) for In(3+) exchange into CIS NCs...
June 13, 2017: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/28636913/heterogeneous-tau-tubulin-complexes-accelerate-microtubule-polymerization
#10
Xiao-Han Li, Elizabeth Rhoades
Tau is an intrinsically disordered protein with a central role in the pathology of a number of neurodegenerative diseases. Tau normally functions to stabilize neuronal microtubules, although the mechanism underlying this function is not well understood. Of note is that the interaction between tau and soluble tubulin, which has implications both in understanding tau function as well as its role in disease, is underexplored. Here we investigate the relationship between heterogeneity in tau-tubulin complexes and tau function...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28634386/shape-and-composition-control-of-monodisperse-hybrid-pt-coo-nanocrystals-by-controlling-the-reaction-kinetics-with-additives
#11
Hyunje Woo, Eunji Kim, Jun-Hyuk Kim, Su-Won Yun, Ji Chan Park, Yong-Tae Kim, Kang Hyun Park
Here, we report the effect of Fe(CO)5 additives in the synthesis of branched Pt-CoO nanowires (NWs) and core@shell concave nanocubes (NCs), in a one-pot system. Key to the success of this synthesis is control over the shape of the Pt seeds by controlling the quantity of Fe(CO)5 additive. In the absence of Fe(CO)5, branched Pt-CoO NWs were synthesized through the attachment of small Pt seed particles, followed by the growth of CoO by deposition. On the other hand, Pt@CoO concave NCs were obtained in the presence of Fe(CO)5 because of the stronger adsorption of Co on the Pt (100) surfaces than on the closely packed (111) surfaces...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634302/structure-of-human-fe-s-assembly-subcomplex-reveals-unexpected-cysteine-desulfurase-architecture-and-acyl-acp-isd11-interactions
#12
Seth A Cory, Jonathan G Van Vranken, Edward J Brignole, Shachin Patra, Dennis R Winge, Catherine L Drennan, Jared Rutter, David P Barondeau
In eukaryotes, sulfur is mobilized for incorporation into multiple biosynthetic pathways by a cysteine desulfurase complex that consists of a catalytic subunit (NFS1), LYR protein (ISD11), and acyl carrier protein (ACP). This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters. Here we present crystallographic and electron microscopic structures of the SDA complex coupled to enzyme kinetic and cell-based studies to provide structure-function properties of a mitochondrial cysteine desulfurase...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28633361/evolution-of-mirna-tailing-by-3-terminal-uridylyl-transferases-in-metazoa
#13
Vengamanaidu Modepalli, Yehu Moran
In bilaterian animals the 3' ends of microRNAs (miRNAs) are frequently modified by tailing and trimming. These modifications affect miRNA-mediated gene regulation by modulating miRNA stability. Here we analyzed data from three non-bilaterian animals: two cnidarians (Nematostella vectensis and Hydra magnipapillata) and one poriferan (Amphimedon queenslandica). Our analysis revealed that non-bilaterian miRNAs frequently undergo modifications like the bilaterian counterparts: the majority are expressed as different length isoforms and frequent modifications of the 3' end by mono U or mono A tailing are observed...
June 14, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28632302/sequentially-responsive-shell-stacked-nanoparticles-for-deep-penetration-into-solid-tumors
#14
Jinjin Chen, Jianxun Ding, Yucai Wang, Jianjun Cheng, Shengxiang Ji, Xiuli Zhuang, Xuesi Chen
Nanomedicine to overcome both systemic and tumor tissue barriers ideally should have a transformable size and surface, maintaining a certain size and negative surface charge for prolonged circulation, while reducing to a smaller size and switching to a positive surface charge for efficient penetration to and retention in the interstitial space throughout the tumor tissue. However, the design of such size and charge dual-transformable nanomedicine is rarely reported. Here, the design of a shell-stacked nanoparticle (SNP) is reported, which can undergo remarkable size reduction from about 145 to 40 nm, and surface charge reversal from -7...
June 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28629580/folding-underlies-bidirectional-role-of-gpr37-pael-r-in-parkinson-disease
#15
REVIEW
Lina Leinartaité, Per Svenningsson
Since conformational flexibility, which is required for the function of a protein, comes at the expense of structural stability, many proteins, including G-protein-coupled receptors (GPCRs), are under constant risk of misfolding and aggregation. In this regard GPR37 (also named PAEL-R and ETBR-LP-1) takes a prominent role, particularly in relation to Parkinson disease (PD). GPR37 is a substrate for parkin and accumulates abnormally in autosomal recessive juvenile parkinsonism, contributing to endoplasmic reticulum stress and death of dopaminergic neurons...
June 16, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28629186/design-and-performance-of-a-portable-and-multichannel-spr-device
#16
Xiao-Ling Zhang, Yan Liu, Ting Fan, Ning Hu, Zhong Yang, Xi Chen, Zhen-Yu Wang, Jun Yang
A portable multichannel surface plasmon resonance (SPR) biosensor device is presented in this study. As an optical biosensor device, the core component of its light path is a semi-cylindrical prism, which is used as the coupling unit for the excitation of the SPR phenomena. Based on this prism, a wedge-shaped incident light beam including a continuous angle range (10°) is chosen to replace the commonly-used parallel light beam in traditional SPR devices, in which the incident angle is adjusted by a sophisticated mechanical system...
June 19, 2017: Sensors
https://www.readbyqxmd.com/read/28629042/functionalization-of-zno-nanoparticles-by-3-mercaptopropionic-acid-for-aqueous-curcumin-delivery-synthesis-characterization-and-anticancer-assessment
#17
Seyed-Behnam Ghaffari, Mohammad-Hossein Sarrafzadeh, Zahra Fakhroueian, Shadab Shahriari, M Reza Khorramizadeh
Inherent biocompatibility and stability of zinc oxide nanoparticles (ZnO-NPs) and their biomedical potentials make them an emerging candidate for drug delivery. The aim of this study was to develop and assess a simple procedure for surface functionalization of ZnO-NPs by 3-mercaptopropionic acid (MPA) for water-soluble curcumin delivery. Carboxyl-terminated ZnO nanoparticles were successfully made using ZnCl2 and NaOH in the presence of MPA. The functional groups were activated by 1,1'-carbonyldiimidazole (CDI) and the curcumin bonding was carried out at room temperature for 24h...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628726/coinage-metal-superatomic-cores-insights-into-their-intrinsic-stability-and-optical-properties-from-relativistic-dft-calculations
#18
Alvaro Rafael Muñoz-Castro, Franck Gam, Dayan Paez-Hernandez, Ramiro Arratia-Perez, C W Liu, Samia Kahlal, Jean-Yves Saillard
Coinage-metal atomically precise nanoclusters are made of a well-defined metallic core embedded in a ligand-protecting outer shell. Whereas gold derivatives are particularly well documented, examples of silver nanoclusters are somewhat limited and copper species remain particularly scare. Our DFT relativistic calculations on superatomic metallic cores indicate that copper species are almost as stable as gold clusters and more stable than their silver counterparts. Thus, for silver superatomic cores, the role of the stabilizing ligands is more crucial in the stabilization of the overall structure, in comparison to copper and gold...
June 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28627018/the-nucleotide-free-state-of-heterotrimeric-g-proteins-%C3%AE-subunit-adopts-a-highly-stable-conformation
#19
Sai Krishna Andhirka, Ravichandran Vignesh, Gopala Krishna Aradhyam
Deciphering the mechanism of activation of heterotrimeric G proteins by their cognate receptors continues to be an intriguing area of research. The recently solved crystal structure of the ternary complex captured the receptor-bound α-subunit in an open conformation, without bound nucleotide has improved our understanding of the activation process. Despite these advancements, the mechanism by which the receptor causes GDP release from the α-subunit remains elusive. To elucidate the mechanism of activation, we studied guanine nucleotide-induced structural stability of the α-subunit (in response to thermal/chaotrope-mediated stress)...
June 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28624725/multifunctional-polymeric-micelles-loaded-with-doxorubicin-and-poly-dithienyl-diketopyrrolopyrrole-for-near-infrared-light-controlled-chemo-phototherapy-of-cancer-cells
#20
Hui Liu, Kai Wang, Cangjie Yang, Shuo Huang, Mingfeng Wang
Polymeric micelles loaded with multiple therapeutic modalities are important to overcome challenges such as drug resistance and improve the therapeutic efficacy. Here we report a new polymer micellar drug carrier that integrates chemotherapy and photothermal therapy in a single platform. Specifically, a narrow bandgap poly(dithienyl-diketopyrrolopyrrole) (PDPP) polymer was encapsulated together with a model anticancer drug doxorubicin (DOX) in the hydrophobic cores of polymeric micelles formed by Pluronic F127, an amphiphilic poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer...
June 3, 2017: Colloids and Surfaces. B, Biointerfaces
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