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Functional neurological

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https://www.readbyqxmd.com/read/28944946/nerve-grafting-vs-common-infraclavicular-intraplexal-nerve-transfer-in-elbow-flexion-restoration
#1
Vesna SİMİć, Andrija SAVİć, Milan JOVANOVİć, Filip VİTOšEVİć, Branko ĐUROVİć, Čedomir MİLOšEVİć, Novak LAKİćEVİć, Miroslav SAMARDžİć, Lukas RASULİć
AIM: The aim of this study is to compare the results of nerve grafting vs. common infraclavicular intraplexal nerve transfer in elbow flexion restoration. MATERIAL AND METHODS: The study included 39 patients with upper brachial plexus palsy who were operated using common intraplexal nerve transfer (Oberlin procedure) and the thoracodorsal and medial pectoral nerve transfer to the musculocutaneous nerve or grafting of C5 to the musculocutneous nerve, for elbow flexion restoration...
July 12, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944915/neuroprotective-effect-of-total-flavonoids-from-ilex-pubescens-against-focal-cerebral-ischemia-reperfusion-injury-in-rats
#2
Xiaoyan Fang, Yujie Li, Jingyi Qiao, Ying Guo, Mingsan Miao
Ilex pubescens is commonly used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases, such as coronary artery disease and stroke. However, the underlying mechanisms remain to be fully elucidated. The aim of the present study was to investigate the effects of Ilex pubescens total flavonoids (IPTF) on neuroprotection and the potential mechanisms in a rat model of focal cerebral ischemia/reperfusion (I/R) injury. Rats were pretreated with intragastric administration of IPTF at doses of 200 and 100 mg/kg for 5 days; middle cerebral artery occlusion surgery was then performed to induce cerebral I/R injury...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944912/dhhp%C3%A2-6-attenuates-cerebral-ischemia%C3%A2-reperfusion-injury-in-rats-through-the-inhibition-of-apoptosis
#3
Yingshi Ji, Xin Yan, Yang Hu, Huan Xue, Jianfeng Sun, Huaqiu Chen, Jiayu Zhang, Liping Wang, Baigong Xue, Li Sun
As a novel reactive oxygen species (ROS) scavenger, deuterohemin His peptide‑6 (DhHP‑6) has been demonstrated to prolong the lifespan of Caenorhabditis elegans and has also exhibited protective effects in myocardial ischemia‑reperfusion injury. Whether similar effects occur during cerebral ischemia‑reperfusion (CIR) injury remains to be elucidated. The present study evaluated the function of DhHP‑6 and its underlying mechanisms in a middle cerebral artery occlusion (MCAO) model in rats. The focal transient MCAO model was implemented using the Longa method of ischemia for 2 h followed by reperfusion for 22 h in male Wistar rats...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944854/effect-of-hippocampal-l%C3%A2-nbp-on-bdnf-and-trkb-expression-and-neurological-function-of-vascular-dementia-rats
#4
Yujing Huang, Zhaohui Li, Guangxian Nan
The pathogenesis of vascular dementia (VD) is associated with neuronal degeneration, apoptosis or necrosis following ischemic brain injury. L‑butylphthalide (L‑NBP), has been demonstrated to exhibit potent anti‑ischemic and anti‑VD effects, however the associated specific mechanism remains to be elucidated. The present study generated a VD rat model, in which the effect of L‑NBP on neurological function and expression levels of brain‑derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) were observed...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944827/cerebral-ischemia-reperfusion-injury-induces-airway-mucus-hypersecretion-in-rats-and-activates-il%C3%A2-13%C3%A2-associated-inflammatory-mechanisms
#5
Baoning Xu, Lei Zhang, Yuqin Che, Chengyang Song, Wenjun Jiang, Jianhua Fan, Dali Tian
The majority of patients that suffer a stroke have excessive sputum, which accelerates the development of pulmonary complications. However, it is unclear whether cerebral ischemia and reperfusion (I/R) injury induces mucus hypersecretion, and the potential role of inflammation remains unknown. In the present study, the reversible middle cerebral artery occlusion model was applied in rats to induce cerebral I/R injury. The rats were grouped according to the duration of reperfusion (6, 12, 24, 48 and 72 h). Neurological dysfunction was evaluated by Longa scoring and lung dry‑to‑wet weight (dw/ww) ratios were determined to reflect the degree of mucus secretion...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944699/compiling-standardized-information-from-clinical-practice-using-content-analysis-and-icf-linking-rules-in-a-goal-oriented-youth-rehabilitation-program
#6
Nadia A Lustenberger, Birgit Prodinger, Delgerjargal Dorjbal, Sara Rubinelli, Klaus Schmitt, Anke Scheel-Sailer
PURPOSE: To illustrate how routinely written narrative admission and discharge reports of a rehabilitation program for eight youths with chronic neurological health conditions can be transformed to the International Classification of Functioning, Disability and Health. METHODS: First, a qualitative content analysis was conducted by building meaningful units with text segments assigned of the reports to the five elements of the Rehab-Cycle(®): goal; assessment; assignment; intervention; evaluation...
September 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28944608/coexistence-of-mutations-in-keratin-10-krt10-and-the-mitochondrial-genome-in-a-patient-with-ichthyosis-with-confetti-and-leber-s-hereditary-optic-neuropathy
#7
Agnieszka Kalinska-Bienias, Agnieszka Pollak, Cezary Kowalewski, Urszula Lechowicz, Piotr Stawinski, Aleksandra Gergont, Joanna Kosinska, Ewa Pronicka, Pawel Kowalski, Katarzyna Wozniak, Rafal Ploski
Ichthyosis with confetti (IWC) is a severe congenital genodermatosis characterized by ichthyosiform erythroderma since birth and confetti-like spots of normal skin appearing in childhood as a results of revertant mosaicism. This disorder is caused by mutations in KRT10 or KRT1 genes. We report a 16-year-old boy who presented ichthyosiform erythroderma with severe desquamation since birth and gradually worsening psycho-neurological symptoms (mental retardation, ataxia, dystonia, hypoacusis). The patient conspicuously lacked typical confetti-like spots at the age of 16...
September 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28943540/amyloid-polyneuropathy-and-myocardial-amyloidosis-10-years-after-domino-liver-transplantation-from-a-patient-with-a-transthyretin-ser50arg-mutation
#8
Masaaki Matsushima, Ichiro Yabe, Masaya Tsuda, Mamoru Sakakibara, Tsuyoshi Shimamura, Hidenao Sasaki
A 54-year-old man with polycystic liver disease received a domino liver transplantation (DLT) from a patient of hereditary ATTR amyloidosis with the transthyretin Ser50Arg mutation. Ten years after transplantation, he felt a slight numbness in his toes, and cardiac amyloidosis was simultaneously suspected upon a heart function evaluation. Biopsy specimens from the myocardium revealed transthyretin amyloidosis with the Ser50Arg mutation. Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943513/neonatal-diabetes-two-cases-with-isolated-pancreas-agenensis-due-to-homozygous-ptf1a-enhancer-mutations-and-one-with-dend-syndrome-due-to-kcnj11-mutation
#9
Olcay Evliyaoğlu, Oya Ercan, Emel Ataloğlu, Ümit Zübarioğlu, Bahar Özcabı, Aydilek Dağdeviren, Hande Erdoğan, Elisa De Franco, Sian Ellard
Neonatal diabetes mellitus is a rare form of monogenic diabetes which is diagnosed in the first 6 months of life. Here we report three patients with neonatal diabetes; two with isolated pancreas agenesis due to mutations in the PTF1A enhancer and one with DEND syndrome (developmental delay, epilepsy, and neonatal diabetes) due to a KCNJ11 mutation. The two cases with mutations in the distal enhacer of PTF1A had a homozygous g.23508363A>G and a homozygous g.23508437A>G mutation respectively. Previous functional analysis showed that these mutations can decrease expression of PTF1A which is involved in pancreas development...
September 25, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28943419/severe-cerebral-complications-secondary-to-perforation-injury-of-the-anterior-skull-base-during-sinonasal-surgery-an-underappreciated-problem
#10
Shadi Al-Afif, Elvis J Hermann, Gökce Hatipoglu Majernik, Makoto Nakamura, Peter Raab, Thomas Lenarz, Joachim K Krauss
OBJECTIVE: Functional endonasal sinus surgery (FESS) is widely practiced and is considered a generally safe procedure. Skull base injuries occur in less than 1% of procedures and are typically associated with cerebrospinal fluid leaks. Rarely, skull base injuries might result in cerebral lesions. Here we present a series of four patients with iatrogenic perforating injuries of the anterior skull base and cerebral lesions after routine FESS. METHODS: Four patients with iatrogenic perforating cerebral lesions after routine FESS performed at other institutions were referred to a tertiary neurosurgery department within a 10-year period...
September 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28943274/gene-therapy-induced-antigen-specific-tregs-inhibit-neuro-inflammation-and-reverse-disease-in-a-mouse-model-of-multiple-sclerosis
#11
Geoffrey D Keeler, Sandeep Kumar, Brett Palaschak, Emily L Silverberg, David M Markusic, Noah T Jones, Brad E Hoffman
The devastating neurodegenerative disease multiple sclerosis (MS) could substantially benefit from an adeno-associated virus (AAV) immunotherapy designed to restore a robust and durable antigen-specific tolerance. However, developing a sufficiently potent and lasting immune-regulatory therapy that can intervene in ongoing disease is a major challenge and has thus been elusive. We addressed this problem by developing a highly effective and robust tolerance-inducing in vivo gene therapy. Using a pre-clinical animal model, we designed a liver-targeting gene transfer vector that expresses full-length myelin oligodendrocyte glycoprotein (MOG) in hepatocytes...
September 19, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28942469/early-versus-late-diagnosis-of-complement-factor-i-deficiency-clinical-consequences-illustrated-in-two-families-with-novel-homozygous-cfi-mutations
#12
Clara Franco-Jarava, Elena Álvarez de la Campa, Xavier Solanich, Francisco Morandeira-Rego, Virgínia Mas-Bosch, Marina García-Prat, Xavier de la Cruz, Andrea Martín-Nalda, Pere Soler-Palacín, Manuel Hernández-González, Roger Colobran
The complement system is an important effector arm of innate immunity and plays a crucial role in the defense against common pathogens. But effective defense and maintenance of homeostasis requires a careful balance between complement activation and regulation. Factor I (FI) is one of the most important regulators of the complement system. Complete FI deficiency is a rare autosomal recessive disorder typically resulting in severe, recurrent infection by encapsulated bacteria. In the present study, we describe two patients from unrelated families with complete FI deficiency diagnosed at very different ages: Patient 1 is a 60-year-old man who had experienced several severe infections (pneumonia, meningitis, sepsis) since childhood, one of which caused significant and permanent neurologic sequelae...
September 23, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28942450/cognitive-function-and-prognosis-of-multimodal-neuroimage-guided-thrombectomy-on-mild-to-moderate-anterior-circulation-infarction-patients-with-broadened-therapeutic-window-a-prospective-study
#13
Guodong Xu, Xiaoli Dong, Xiaoli Niu, Guimin Zheng, Hebo Wang, Fan Zhang, Litao Li, Peiyuan Lv
BACKGROUND AND OBJECTIVES: Endovascular mechanical thrombectomy is an important approach for acute ischemic stroke (AIS) treatment. Multimodal neuroimaging methods ideally provide the exact localization, extent, and metabolic activity of target tissues. Post-stroke cognitive impairment has recently been realized to be another major concern except for neurological function impairment. The aim of our study was to carry out a prospective study to compare neurological and cognitive functions after thrombectomy in mild to moderate anterior circulation infarction patients selected by multimodal neuroimaging...
September 22, 2017: European Neurology
https://www.readbyqxmd.com/read/28942217/risperidone-versus-olanzapine-among-patients-with-schizophrenia-participating-in-supported-employment-eighteen-month-outcomes
#14
Douglas L Noordsy, Shirley M Glynn, Catherine A Sugar, Christopher D O'Keefe, Stephen R Marder
This study compares the efficacy and tolerability of olanzapine versus risperidone among patients with schizophrenia who are established in outpatient psychiatric care and entering supported employment. A multicenter, randomized, double-blind trial was conducted among 107 outpatients with schizophrenia, who were cross-titrated to flexible dose risperidone or olanzapine over 2 weeks. Clinical endpoints included time to hospitalization and persistence on assigned medication. Weight, laboratory tests, psychopathology, neurologic side effects, social adjustment and role functioning were assessed at 3-6 month intervals...
September 8, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28942061/the-behavioral-and-cognitive-relevance-of-time-varying-dynamic-changes-in-functional-connectivity
#15
REVIEW
Jessica R Cohen
Recent advances in neuroimaging methods and analysis have led to an expanding body of research that investigates how large-scale brain network organization dynamically adapts to changes in one's environment, including both internal state changes and external stimulation. It is now possible to detect changes in functional connectivity that occur on the order of seconds, both during an unconstrained resting state and during the performance of constrained cognitive tasks. It is thought that these dynamic, time-varying changes in functional connectivity, often referred to as dynamic functional connectivity (dFC), include features that are relevant to behavior and cognition...
September 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28942060/functional-networks-and-network-perturbations-in-rodents
#16
REVIEW
Kai-Hsiang Chuang, Fatima A Nasrallah
Synchronous low-frequency oscillation in the resting human brain has been found to form networks of functionally associated areas and hence has been widely used to map the functional connectivity of the brain using techniques such as resting-state functional MRI (rsfMRI). Interestingly, similar resting-state networks can also be detected in the anesthetized rodent brain, including the default mode-like network. This opens up opportunities for understanding the neurophysiological basis of the rsfMRI signal, the behavioral relevance of the network characteristics, connectomic deficits in diseases and treatment effects on brain connectivity using rodents, particularly transgenic mouse models...
September 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28942018/integration-of-fmri-and-meg-functional-maps-into-a-cyberknife-planning-system-feasibility-study-for-motor-activity-localization-and-dose-planning
#17
Elena De Martin, Dunja Duran, Francesco Ghielmetti, Elisa Visani, Domenico Aquino, Marcello Marchetti, Davide Rossi Sebastiano, Davide Cusumano, Maria Grazia Bruzzone, Ferruccio Panzica, Laura Fariselli
OBJECTIVE: Magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) provide non-invasive localization of eloquent brain areas for pre-surgical planning. The aim of this study is the integration of MEG and fMRI maps into a CyberKnife (CK) system to optimize dose planning. METHODS: Four patients with brain metastases in the motor area underwent functional imaging study of the hand motor cortex prior radiosurgery. MEG data were acquired during a visually cued hand motor-task...
September 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28941960/rcvibro-system-full-description-of-a-custom-made-vibratory-system-and-its-reliability
#18
Marcelo Pinto Pereira, Paulo Henrique Silva Pelicioni, Lilian Teresa Bucken Gobbi
BACKGROUND: The use of local muscle vibration is a promising technique to improve motor performance in people with movement impairments. Majority of studies have failed to properly describe the used system and its reliability, making it difficult to transfer this promising technique to clinical practice. OBJECTIVE: To describe technical details of a custom-made vibratory system (RCVibro System), as well as to determine its reliability and functionality. METHODS: The vibration frequency and the electric potential difference/vibration frequency curve of six devices were assessed (at the same day and at different days), allowing us to determine the system reliability...
September 7, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28941829/the-clinical-features-and-functional-impact-of-valproate-induced-tremor
#19
Marlene Alonso-Juarez, Diego Torres-Russotto, Paulina Crespo-Morfin, José Fidel Baizabal-Carvallo
BACKGROUND: Tremor is a known side-effect of anticonvulsants, particularly of valproate. However, there is a dearth of information regarding detailed clinical features and functional impact of valproate-induced tremor. METHODS: We studied a cohort of patients treated with anticonvulsants for neurological disorders, through blinded evaluations using the Clinical Rating Scale for Tremor (CRST); we compared the frequency, severity and functional impact of drug-induced tremor between patients treated with valproate and those treated with other anticonvulsants...
September 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28941770/characterisation-of-spinophilin-immunoreactivity-in-postmortem-human-brain-homogenates
#20
I Brocos-Mosquera, A Nuñez Del Moral, B Morentin, J Javier Meana, Luis F Callado, Amaia M Erdozain
Spinophilin is a multifunctional scaffold protein that regulates the formation and function of dendritic spines and plays a role in neuronal migration. The distinct roles of spinophilin depend on its localization and the direct interaction with other proteins, which may target spinophilin to specific locations within the cell. Several studies suggest a role of spinophilin in the pathophysiology of neurological or psychiatric diseases. However, the majority have been performed in animals or cultured cells. Thus, the aim of the present study was to characterise the regional and subcellular expression of spinophilin immunoreactivity by western blot in postmortem human brain...
September 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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