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https://www.readbyqxmd.com/read/28614281/transcranial-motor-evoked-potential-alarm-criteria-to-predict-foot-drop-injury-during-lumbosacral-surgery
#1
Arvydas Tamkus, Kent S Rice, Gregory Hoffman
STUDY DESIGN: Retrospective cohort analysis. OBJECTIVE: This study aims to investigate whether waveform alterations in transcranial motor evoked potentials (TCMEP) can reliably predict postoperative foot drop. SUMMARY OF BACKGROUND DATA: Nerve injury leading to foot drop is a potential complication of lumbosacral surgery. Very limited data exist on the use of intraoperative TcMEPs to identify iatrogenic foot drop. METHODS: We retrospectively reviewed neuromonitoring data from 130 consecutive spine surgeries with instrumentation involving L4-S1...
June 13, 2017: Spine
https://www.readbyqxmd.com/read/28598292/effects-of-primary-and-recurrent-sacral-chordoma-on-the-motor-and-nociceptive-function-of-hindlimbs-in-rats-an-orthotopic-spine-model
#2
Rachel Sarabia-Estrada, Alejandro Ruiz-Valls, Sagar R Shah, A Karim Ahmed, Alvaro A Ordonez, Fausto J Rodriguez, Hugo Guerrero-Cazares, Ismael Jimenez-Estrada, Esteban Velarde, Betty Tyler, Yuxin Li, Neil A Phillips, C Rory Goodwin, Rory J Petteys, Sanjay K Jain, Gary L Gallia, Ziya L Gokaslan, Alfredo Quinones-Hinojosa, Daniel M Sciubba
OBJECTIVE Chordoma is a slow-growing, locally aggressive cancer that is minimally responsive to conventional chemotherapy and radiotherapy and has high local recurrence rates after resection. Currently, there are no rodent models of spinal chordoma. In the present study, the authors sought to develop and characterize an orthotopic model of human chordoma in an immunocompromised rat. METHODS Thirty-four immunocompromised rats were randomly allocated to 4 study groups; 22 of the 34 rats were engrafted in the lumbar spine with human chordoma...
June 9, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28560607/femoral-nerve-and-lumbar-plexus-injury-after-minimally-invasive-lateral-retroperitoneal-transpsoas-approach-electrodiagnostic-prognostic-indicators-and-a-roadmap-to-recovery
#3
Naomi A Abel, Jacob Januszewski, Andrew C Vivas, Juan S Uribe
Injury to the lumbosacral (LS) plexus is a well-described complication after lateral retroperitoneal transpsoas approaches to the spine. The prognosis for functional recovery after lumbosacral plexopathy or femoral/obturator neuropathy is unclear. We designed a retrospective case-control study with patients undergoing one-level lateral retroperitoneal transpsoas lumbar interbody fusion (LLIF) between January 2011 and June 2016 to correlate electrodiagnostic assessments (EDX) to physiologic concepts of nerve injury and reinnervation, and attempt to build a timeline for patient evaluation and recovery...
May 30, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28545157/the-aminoestrogen-prolame-increases-recognition-memory-and-hippocampal-neuronal-spine-density-in-aged-mice
#4
Alfonso Diaz, Samuel Treviño, Rubén Vázquez-Roque, Berenice Venegas, Blanca Espinosa, Gonzalo Flores, Juan Manuel Fernández-G, Luis F Montaño, Jorge Guevara
The aging brain shows biochemical and morphological changes in the dendrites of pyramidal neurons from the limbic system associated with memory loss. Prolame (N-(3-hydroxy-1,3,5 (10) -estratrien-17β-yl) -3-hydroxypropylamine) is a non-feminizing aminoestrogen with antithrombotic activity that prevents neuronal deterioration, oxidative stress and neuroinflammation. Our aim was to evaluate the effect of prolame on motor and cognitive processes, as well as its influence on the dendritic morphology of neurons at the CA1, CA3 and granule cells of the dentate gyrus (DG) regions of hippocampus (HP), and medium spiny neurons of the nucleus accumbens (NAcc) of aged mice...
May 25, 2017: Synapse
https://www.readbyqxmd.com/read/28505961/effects-of-dual-task-conditions-on-cervical-spine-movement-variability
#5
Daniel Niederer, Lutz Vogt, Johanna Vogel, Winfried Banzer
BACKGROUND: The potential to accurately perform cervical movements during more challenging tasks might be of importance to prevent dysfunctional motion characteristics. Although sensorimotor function during dual-task conditions are of increasing interest in biomedical and rehabilitation research, effects of such conditions on movement consistency of the neck have not yet been investigated. OBJECTIVE: In this crossover MiSpEx(Medicine in Spine Exercise)-diagnostic study, we aimed to explore differences between single and dual-task conditions on cervical movement variability...
May 5, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28505229/oligodendrocyte-and-neuron-specific-nogo-a-restrict-dendritic-branching-and-spine-density-in-the-adult-mouse-motor-cortex
#6
Ajmal Zemmar, Chia-Chien Chen, Oliver Weinmann, Brigitt Kast, Flora Vajda, James Bozeman, Noel Isaad, Yi Zuo, Martin E Schwab
Nogo-A has been well described as a myelin-associated inhibitor of neurite outgrowth and functional neuroregeneration after central nervous system (CNS) injury. Recently, a new role of Nogo-A has been identified as a negative regulator of synaptic plasticity in the uninjured adult CNS. Nogo-A is present in neurons and oligodendrocytes. However, it is yet unclear which of these two pools regulate synaptic plasticity. To address this question we used newly generated mouse lines in which Nogo-A is specifically knocked out in (1) oligodendrocytes (oligoNogo-A KO) or (2) neurons (neuroNogo-A KO)...
May 15, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28486863/the-influence-of-the-use-of-ankle-foot-orthoses-on-thorax-spine-and-pelvis-kinematics-during-walking-in-children-with-cerebral-palsy
#7
Eva Swinnen, Jean-Pierre Baeyens, Benjamin Van Mulders, Julian Verspecht, Marc Degelaen
BACKGROUND: To improve gait function in children with cerebral palsy, ankle-foot orthoses are often prescribed. However, until now, little attention has been devoted to the effect of ankle-foot orthoses on the postural control during walking in children with cerebral palsy. OBJECTIVES: The aim was to compare the differences in thorax, spine, and pelvis movements in children with cerebral palsy during walking barefoot and walking with ankle-foot orthoses. STUDY DESIGN: Clinical study with an intra subject design...
May 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28462043/lack-of-riluzole-efficacy-in-the-progression-of-the-neurodegenerative-phenotype-in-a-new-conditional-mouse-model-of-striatal-degeneration
#8
Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
BACKGROUND: Huntington's disease (HD) is a rare familial autosomal dominant neurodegenerative disorder characterized by progressive degeneration of medium spiny neurons (MSNs) located in the striatum. Currently available treatments of HD are only limited to alleviating symptoms; therefore, high expectations for an effective therapy are associated with potential replacement of lost neurons through stimulation of postnatal neurogenesis. One of the drugs of potential interest for the treatment of HD is riluzole, which may act as a positive modulator of adult neurogenesis, promoting replacement of damaged MSNs...
2017: PeerJ
https://www.readbyqxmd.com/read/28460690/pain-catastrophizing-moderates-changes-in-spinal-control-in-response-to-noxiously-induced-low-back-pain
#9
Gwyneth B Ross, Peter J Sheahan, Brian Mahoney, Brendon J Gurd, Paul W Hodges, Ryan B Graham
It is generally accepted that spine control and stability are relevant for the prevention and rehabilitation of low back pain (LBP). However, there are conflicting results in the literature in regards to how these variables are modified in the presence of LBP. The aims of the present work were twofold: (1) to use noxious stimulation to induce LBP in healthy individuals to assess the direct effects of pain on control (quantified by the time-dependent behavior of kinematic variance), and (2) to assess whether the relationship between pain and control is moderated by psychological features (i...
April 19, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28450828/spine-enlargement-of-pyramidal-tract-type-neurons-in-the-motor-cortex-of-a-rat-model-of-levodopa-induced-dyskinesia
#10
Tatsuya Ueno, Haruo Nishijima, Shinya Ueno, Masahiko Tomiyama
Growing evidence suggests that abnormal synaptic plasticity of cortical neurons underlies levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). Spine morphology reflects synaptic plasticity resulting from glutamatergic transmission. We previously reported that enlargement of the dendritic spines of intratelencephalic-type (IT) neurons in the primary motor cortex (M1) is linked to the development of LID. However, the relevance of another M1 neuron type, pyramidal-tract (PT) neurons, to LID remains unknown...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28427472/optimising-conservative-management-of-chronic-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#11
Katherine J Simson, Clint T Miller, Jon Ford, Andrew Hahne, Luana Main, Timo Rantalainen, Wei-Peng Teo, Megan Teychenne, David Connell, Guy Trudel, Guoyan Zheng, Gary Thickbroom, Daniel L Belavy
BACKGROUND: Lower back pain is a global health issue affecting approximately 80% of people at some stage in their life. The current literature suggests that any exercise is beneficial for reducing back pain. However, as pain is a subjective evaluation and physical deficits are evident in low back pain, using it as the sole outcome measure to evaluate superiority of an exercise protocol for low back pain treatment is insufficient. The overarching goal of the current clinical trial is to implement two common, conservative intervention approaches and examine their impact on deficits in chronic low back pain...
April 20, 2017: Trials
https://www.readbyqxmd.com/read/28409420/single-fraction-spine-stereotactic-ablative-body-radiotherapy-with-volumetric-modulated-arc-therapy
#12
Matthew M Gestaut, Nitika Thawani, Sangroh Kim, Veera R Gutti, Sameer Jhavar, Niloyjyoti Deb, Andrew Morrow, Russell A Ward, Jason H Huang, Mehul Patel
This study investigated a single institution's experience with volumetric modulated arc therapy (VMAT) directed stereotactic ablative body radiotherapy (SABR) for vertebral metastases. From 2010 to 2014, 95 lesions of spinal metastases in 73 patients were treated with SABR using VMAT. Clinical local control, pain level, and use of steroid medication were employed to evaluate treatment responses. The majority (79%) of patients were treated with a radiation dose of 20 Gy in a single fraction. However, when normal tissue constraints could not be achieved, the dose was reduced to 18 Gy (11%) or 16 Gy (8%) in 1 fraction...
April 13, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28363668/methylphenidate-alleviates-manganese-induced-impulsivity-but-not-distractibility
#13
Stephane A Beaudin, Barbara J Strupp, Walter Uribe, Lauren Ysais, Myla Strawderman, Donald R Smith
Recent studies from our lab have demonstrated that postnatal manganese (Mn) exposure in a rodent model can cause lasting impairments in fine motor control and attention, and that oral methylphenidate (MPH) treatment can effectively treat the dysfunction in fine motor control. However, it is unknown whether MPH treatment can alleviate the impairments in attention produced by Mn exposure. Here we used a rodent model of postnatal Mn exposure to determine whether (1) oral MPH alleviates attention and impulse control deficits caused by postnatal Mn exposure, using attention tasks that are variants of the 5-choice serial reaction time task, and (2) whether these treatments affected neuronal dendritic spine density in the medial prefrontal cortex (mPFC) and dorsal striatum...
March 28, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28347671/deletion-of-numb-numblike-in-glutamatergic-neurons-leads-to-anxiety-like-behavior-in-mice
#14
Wenyu Qian, Yang Hong, Minyan Zhu, Liang Zhou, Hongchang Li, Huashun Li
Endocytic adaptor protein Numb is the first identified cell fate determinant in Drosophila melanogaster. It has been implicated in Notch signaling pathway and regulation of neural stem cells proliferation in the central nervous system. Numb is also expressed in postmitotic neurons, in vitro studies showed that Numb is involved in neuronal morphologic development, such as neurite growth, axonal growth and spine development. However, in vivo functions of Numb in the postmitotic neurons are largely unknown. Here we show that deletion of Numb/Numblike in glutamatergic neurons causes anxiety-like behavior in mouse...
March 24, 2017: Brain Research
https://www.readbyqxmd.com/read/28319490/position-between-trunk-and-pelvis-during-gait-depending-on-the-gross-motor-function-classification-system
#15
Jose Manuel Sanz-Mengibar, Natalie Altschuck, Paloma Sanchez-de-Muniain, Christian Bauer, Fernando Santonja-Medina
PURPOSE: To understand whether there is a trunk postural control threshold in the sagittal plane for the transition between the Gross Motor Function Classification System (GMFCS) levels measured with 3-dimensional gait analysis. METHOD: Kinematics from 97 children with spastic bilateral cerebral palsy from spine angles according to Plug-In Gait model (Vicon) were plotted relative to their GMFCS level. RESULTS: Only average and minimum values of the lumbar spine segment correlated with GMFCS levels...
April 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28317555/the-cervical-spine-of-australopithecus-sediba
#16
Marc R Meyer, Scott A Williams, Peter Schmid, Steven E Churchill, Lee R Berger
Cervical vertebrae are rare in the early hominin fossil record, presenting a challenge for understanding the evolution of the neck and head carriage in hominin evolution. Here, we examine the cervical vertebrae of Australopithecus sediba, which unlike other South African taxa is known from associated cervical vertebrae. The A. sediba cervical vertebrae exhibit human-like values for wedging, pedicle cross-sectional areas, and articular facet heights, indicating reduced ventral loading relative to African apes...
March 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28277467/high-energy-pediatric-scapula-fractures-and-their-associated-injuries
#17
Steven F Shannon, Nicholas M Hernandez, Stephen A Sems, Annalise N Larson, Todd A Milbrandt
OBJECTIVES: The purpose of this study was to evaluate pediatric scapula fractures occurring in high-energy motorized vehicle accidents and their associated injury patterns in a pediatric patient population. METHODS: One thousand nine hundred sixty-eight pediatric patients who presented after either on-road or off-road motorized vehicle accidents between 1996 and 2015 were retrospectively reviewed. Thirty-eight patients were found to have scapula fractures and the remaining 1930 were identified as controls...
March 8, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28266225/stereotactic-radiosurgery-and-stereotactic-fractionated-radiotherapy-for-metastatic-tumors-of-the-spine
#18
Juan Manuel L Mariano, Erickson F Torio, Ma Socorro S D Santos, Ibet Marie Y Sih, Roy Allan Dominique G Torcuator
OBJECTIVES: The objectives of this paper are to describe pain control, neurologic improvement, local tumor control, progression-free survival, and overall survival of spine SRS/SFRT patients, and to compare our outcomes with other studies on spine stereotactic radiotherapy for metastatic tumors. METHODS: A chart review of patients who underwent spine SRS/SFRT was done. Information was collected on patient age, sex, histology, site treated, pain relief, local control, neurologic function, prescription dose, and complications...
April 2017: Neurological Research
https://www.readbyqxmd.com/read/28259266/predictors-of-health-related-quality-of-life-after-complex-adult-spinal-deformity-surgery-a-scoli-risk-1-secondary-analysis
#19
Leah Y Carreon, Steven D Glassman, Christopher I Shaffrey, Michael G Fehlings, Benny Dahl, Christopher P Ames, Yukihiro Matsuyama, Yong Qiu, Hossein Mehdian, Kenneth M C Cheung, Frank J Schwab, Ferran Pellisé, Khaled M Kebaish, Lawrence G Lenke
STUDY DESIGN: Longitudinal cohort. OBJECTIVES: To identify variables that predict 2-year Short Form-36 Physical Composite Summary Score (SF-36PCS) and the Scoliosis Research Society-22R (SRS22-R) Total score after surgery for complex adult spinal deformity. SUMMARY OF BACKGROUND DATA: Increasingly, treatment effectiveness is assessed by the extent to which the procedure improves a patient's health-related quality of life (HRQOL). This is especially true in patients with complex adult spinal deformity...
March 2017: Spine Deformity
https://www.readbyqxmd.com/read/28247074/early-versus-delayed-reduction-of-cervical-spine-dislocation-with-complete-motor-paralysis-a-multicenter-study
#20
Kosei Nagata, Koichi Inokuchi, Hirotaka Chikuda, Keisuke Ishii, Atsuki Kobayashi, Hiroyuki Kanai, Hiroyuki Nakarai, Kota Miyoshi
PURPOSE: Reduction of cervical facet dislocation should be performed as soon as possible to depressurize neuron cells although some randomized control studies defined early reduction as over 24 h after trauma. The purpose of this study was to define the actual time limit for early reduction in patients with complete motor paralysis. METHODS: Cervical spine dislocation patients with complete motor paralysis admitted between April 2007 and December 2014 were analyzed as retrospective cohort study...
February 28, 2017: European Spine Journal
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