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Motor control spine

Daniel Niederer, Lutz Vogt, Pia-Maria Wippert, Anne-Katrin Puschmann, Ann-Christin Pfeifer, Marcus Schiltenwolf, Winfried Banzer, Frank Mayer
BACKGROUND: Arising from the relevance of sensorimotor training in the therapy of nonspecific low back pain patients and from the value of individualized therapy, the present trial aims to test the feasibility and efficacy of individualized sensorimotor training interventions in patients suffering from nonspecific low back pain. METHODS AND STUDY DESIGN: A multicentre, single-blind two-armed randomized controlled trial to evaluate the effects of a 12-week (3 weeks supervised centre-based and 9 weeks home-based) individualized sensorimotor exercise program is performed...
October 20, 2016: Trials
Thomas Broggini, Lisa Schnell, Ali Ghoochani, José María Mateos, Michael Buchfelder, Kurt Wiendieck, Michael K Schäfer, Ilker Y Eyupoglu, Nicolai E Savaskan
The Plasticity Related Gene family covers five, brain-specific, transmembrane proteins (PRG1-5, also termed LPPR1-5) that operate in neuronal plasticity during development, aging and brain trauma. Here we investigated the role of the PRG family on axonal and filopodia outgrowth. Comparative analysis revealed the strongest outgrowth induced by PRG3 (LPPR1). During development, PRG3 is ubiquitously located at the tip of neuronal processes and at the plasma membrane and declines with age. In utero electroporation of PRG3 induced dendritic protrusions and accelerated spine formations in cortical pyramidal neurons...
October 15, 2016: Aging
Nima Toosizadeh, Homayoon Harati, Tzu-Chuan Yen, Cindy Fastje, Jane Mohler, Bijan Najafi, Michael Dohm
BACKGROUND: This study examined short- and long-term improvements in motor performance, quantified using wearable sensors, in response to facet spine injection in degenerative facet osteoarthropathy patients. METHODS: Adults with confirmed degenerative facet osteoarthropathy were recruited and were treated with medial or intermediate branch block injection. Self-report pain, health condition, and disability (Oswestry), as well as objective motor performance measures (gait, balance, and timed-up-and-go) were obtained in five sessions: pre-surgery (baseline), immediately after the injection, one-month, three-month, and 12-month follow-ups...
October 11, 2016: Clinical Biomechanics
Dirk Rades, Antonio J Conde-Moreno, Jon Cacicedo, Barbara Segedin, Volker Rudat, Steven E Schild
BACKGROUND: Uncertainty exists whether patients with spinal cord compression (SCC) from a highly radiosensitive tumor require decompressive spinal surgery in addition to radiotherapy (RT). This study addressed the question by evaluating patients receiving RT alone for SCC from myeloma. PATIENTS AND METHODS: Data of 238 patients were retrospectively analyzed for response to RT and local control of SCC. In addition, the effect of RT on motor function (improvement, no further progression, deterioration) was evaluated...
September 1, 2016: Radiology and Oncology
Mary C Hannah, Janet Cope, Alec Palermo, Walker Smith, Valerie Wacker
STUDY DESIGN: Descriptive comparison study. OBJECTIVE: To assess the accuracy of two needle angle approaches for dry needling of the lumbar multifidus. BACKGROUND: Low back pain is a leading cause of disability around the world; the lumbar multifidus plays a vital role in low back health. Manual therapy such as dry needling can improve pain mediation and motor control activation of the lumbar multifidus. Clinicians practicing dry needling at the lumbar multifidus typically use an inferomedial approach considered non-controversial...
September 4, 2016: Manual Therapy
Olga A Maximova, John G Bernbaum, Alexander G Pletnev
BACKGROUND: During recent West Nile virus (WNV) outbreaks in the US, half of the reported cases were classified as neuroinvasive disease. WNV neuroinvasion is proposed to follow two major routes: hematogenous and/or axonal transport along the peripheral nerves. How virus spreads once within the central nervous system (CNS) remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: Using immunohistochemistry, we examined the expression of viral antigens in the CNS of rhesus monkeys that were intrathalamically inoculated with a wild-type WNV...
September 2016: PLoS Neglected Tropical Diseases
Gabriella R Goshtigian, Brian T Swanson
BACKGROUND: Despite the multidirectional quality of human movement, common measurement procedures used in physical therapy examination are often uni-planar and lack the ability to assess functional complexities involved in daily activities. Currently, there is no widely accepted, validated standard to assess movement quality. The Selective Functional Movement Assessment (SFMA) is one possible system to objectively assess complex functional movements. The purpose of this case report is to illustrate the application of the SFMA as a guide to the examination, evaluation, and management of a patient with non-specific low back pain (LBP)...
August 2016: International Journal of Sports Physical Therapy
Emily E Handley, Kimberley A Pitman, Edgar Dawkins, Kaylene M Young, Rosemary M Clark, Tongcui C Jiang, Bradley J Turner, Tracey C Dickson, Catherine A Blizzard
TDP-43 is a major protein component of pathological neuronal inclusions that are present in frontotemporal dementia and amyotrophic lateral sclerosis. We report that TDP-43 plays an important role in dendritic spine formation in the cortex. The density of spines on YFP(+) pyramidal neurons in both the motor and somatosensory cortex of Thy1-YFP mice, increased significantly from postnatal day 30 (P30), to peak at P60, before being pruned by P90. By comparison, dendritic spine density was significantly reduced in the motor cortex of Thy1-YFP::TDP-43(A315T) transgenic mice prior to symptom onset (P60), and in the motor and somatosensory cortex at symptom onset (P90)...
August 5, 2016: Cerebral Cortex
Matthew J Fogarty, Erica W H Mu, Peter G Noakes, Nickolas A Lavidis, Mark C Bellingham
Amyotrophic lateral sclerosis (ALS) is characterised by the death of upper (corticospinal) and lower motor neurons (MNs) with progressive muscle weakness. This incurable disease is clinically heterogeneous and its aetiology remains unknown. Increased excitability of corticospinal MNs has been observed prior to symptoms in human and rodent studies. Increased excitability has been correlated with structural changes in neuronal dendritic arbors and spines for decades. Here, using a modified Golgi-Cox staining method, we have made the first longitudinal study examining the dendrites of pyramidal neurons from the motor cortex, medial pre-frontal cortex, somatosensory cortex and entorhinal cortex of hSOD1(G93A) (SOD1) mice compared to wild-type (WT) littermate controls at postnatal (P) days 8-15, 28-35, 65-75 and 120...
2016: Acta Neuropathologica Communications
Cecilia Marini, Angelina Cistaro, Cristina Campi, Andrea Calvo, Claudia Caponnetto, Flavio Mariano Nobili, Piercarlo Fania, Mauro C Beltrametti, Cristina Moglia, Giovanni Novi, Ambra Buschiazzo, Annalisa Perasso, Antonio Canosa, Carlo Scialò, Elena Pomposelli, Anna Maria Massone, Maria Caludia Bagnara, Stefania Cammarosano, Paolo Bruzzi, Silvia Morbelli, Gianmario Sambuceti, Gianluigi Mancardi, Michele Piana, Adriano Chiò
PURPOSE: In amyotrophic lateral sclerosis, functional alterations within the brain have been intensively assessed, while progression of lower motor neuron damage has scarcely been defined. The aim of the present study was to develop a computational method to systematically evaluate spinal cord metabolism as a tool to monitor disease mechanisms. METHODS: A new computational three-dimensional method to extract the spinal cord from (18)F-FDG PET/CT images was evaluated in 30 patients with spinal onset amyotrophic lateral sclerosis and 30 controls...
October 2016: European Journal of Nuclear Medicine and Molecular Imaging
Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Allan Abbott, Birgitta Öberg
BACKGROUND: Current guidelines for the management of patients with specific low back pain pathology suggest non-surgical intervention as first-line treatment, but there is insufficient evidence to make recommendations of the content in the non-surgical intervention. Opinions regarding the dose of non-surgical intervention that should be trialled prior to decision making about surgery intervention vary. The aim of the present study is to investigate if physiotherapy administrated before surgery improves function, pain and health in patients with degenerative lumbar spine disorder scheduled for surgery...
2016: BMC Musculoskeletal Disorders
Han Jo Kim, Sravisht Iyer, Luke P Zebala, Michael P Kelly, Daniel Sciubba, Themistocles S Protopsaltis, Munish Gupta, Brian J Neuman, Gregory M Mundis, Christopher P Ames, Justin S Smith, Robert Hart, Douglas Burton, Eric O Klineberg
STUDY DESIGN: Prognostic Study - Case Controlled. OBJECTIVE: Describe the rate of neurologic complications in adult spinal deformity surgery and describe the impact of these complications on clinical outcomes. SUMMARY OF BACKGROUND DATA: The incidence of neurologic complications and the risk factors for neurologic complications has not been reported in a large series of patients with Adult Spinal Deformity (ASD). Existing series include a mixed patient cohort undergoing different types of spine surgery...
July 7, 2016: Spine
Hooi Khee Teo, Mayank Chawla, Manish Kaushik
Herpes zoster is a common presentation in both the community and emergency department; however segmental zoster paresis is a rare complication that can lead to misdiagnosis. We present a case of a 74-year-old Indian gentleman with a background of well controlled diabetes mellitus, hypertension, and ischaemic heart disease who presented with sudden right lower limb weakness. This was preceded by a 5-day history of paraesthesia starting in the right foot and ascending up the right lower limb. On examination, there was a characteristic vesicular rash in the L2/3 region with MRC grading 3/5 in the right hip flexors...
2016: Case Reports in Medicine
R Pavione Rodrigues Pereira, S Nascimento Fagundes, A Surry Lebl, L Azevedo Soster, M G Machado, V H Koch, C Tanaka
INTRODUCTION: Integration of the neuromuscular system is required for maintaining balance and adequate voiding function. Children with enuresis have delayed maturation of the motor cortex, with changes in the sensory and motor systems. Along with various alterations, including the genetic, hormonal, behavioral, and sleep disturbances, and neuromotor and sensory deficits associated with nocturnal enuresis (NE) in children and adults, a consistent alteration in the posture of children with NE has been observed in the current practice...
August 2016: Journal of Pediatric Urology
Jeremy P Morgan, Ashley L Miller, Paul A Thompson, Wilson T Asfora
BACKGROUND: Low back pain and degeneration of the intervertebral disc are an integrated malady that affects millions of Americans. Cage devices used in association with posterior lumbar interbody fusion (PLIF) have been shown to be an effective approach in the treatment of a number of lower spine disorders attributed to degenerative disc disease (DDD). OBJECTIVE: This study was undertaken as part of a U.S. Food and Drug Administration (FDA) Investigational Device Exemption (IDE) study and compares the effectiveness of the Asfora Bullet Cage System (ABCS) to successfully fuse vertebra at one or two levels between L2 and S1 in patients with DDD to an FDA approved comparison device, the Medtronic-Sofamor Danek Inter Fix Threaded Fusion Device (MSDIFD)...
April 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Indira Devi Bhagavatula, Dhaval Shukla, Nishanth Sadashiva, Praveen Saligoudar, Chandrajit Prasad, Dhananjaya I Bhat
OBJECTIVE The physiological mechanisms underlying the recovery of motor function after cervical spondylotic myelopathy (CSM) surgery are poorly understood. Neuronal plasticity allows neurons to compensate for injury and disease and to adjust their activities in response to new situations or changes in their environment. Cortical reorganization as well as improvement in corticospinal conduction happens during motor recovery after stroke and spinal cord injury. In this study the authors aimed to understand the cortical changes that occur due to CSM and following CSM surgery and to correlate these changes with functional recovery by using blood oxygen level-dependent (BOLD) functional MRI (fMRI)...
June 2016: Neurosurgical Focus
Viktor Zsolt Kovari
PURPOSE: To detail the management, complications and results of a crossbow arrow injury, where the broadhead went through the mouth, tongue, soft palate, C2 vertebra, spinal canal, dural sack, exiting the neck posteriorly and the arrow shaft lodged in the spine causing mild spinal cord injury. METHODS: Case presentation. RESULTS: A penetrating axial cervical spine crossbow injury was treated successfully in spite of the following interdisciplinary complications: meningitis, cerebrospinal fluid leakage, re-bleeding, and cardiac arrest...
May 26, 2016: European Spine Journal
Hiroyuki Kida, Yasumasa Tsuda, Nana Ito, Yui Yamamoto, Yuji Owada, Yoshinori Kamiya, Dai Mitsushima
Motor skill training induces structural plasticity at dendritic spines in the primary motor cortex (M1). To further analyze both synaptic and intrinsic plasticity in the layer II/III area of M1, we subjected rats to a rotor rod test and then prepared acute brain slices. Motor skill consistently improved within 2 days of training. Voltage clamp analysis showed significantly higher α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-d-aspartate (AMPA/NMDA) ratios and miniature EPSC amplitudes in 1-day trained rats compared with untrained rats, suggesting increased postsynaptic AMPA receptors in the early phase of motor learning...
August 2016: Cerebral Cortex
Ho Kyu Paik, Sang-Soak Ahn, Jong Yeol Kim, Dal Sung Ryu, Kyung-Hyun Kim, Dong-Kyu Chin, Keun-Su Kim, Yong-Eun Cho, Sung-Uk Kuh
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at
May 5, 2016: Spine Journal: Official Journal of the North American Spine Society
Ammar H Hawasli, Jodie Chang, Chester K Yarbrough, Karen Steger-May, Lawrence G Lenke, Ian G Dorward
BACKGROUND CONTEXT: Spine surgeons must correlate clinical presentation with radiographic findings in a patient-tailored approach. Despite the prevalence of adult degenerative scoliosis (ADS), there are few radiographic markers to predict the presence of radiculopathy. Emerging data suggest that spondylolisthesis, obliquity, foraminal stenosis, and curve concavity may be associated with radiculopathy in ADS. PURPOSE: The purpose of this study was to determine if radicular pain in ADS is associated with reduced interpedicular heights (IPHs) as measured on routine radiographs...
September 2016: Spine Journal: Official Journal of the North American Spine Society
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