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https://www.readbyqxmd.com/read/27875736/emerging-roles-and-mechanisms-of-long-noncoding-rnas-in-atherosclerosis
#1
REVIEW
Yao Liu, Lei Zheng, Qian Wang, Yan-Wei Hu
Atherosclerosis is the most common cause of heart attacks, strokes, and peripheral vascular disease. Atherosclerosis is predicted to be the primary cause of death in the world by 2020. Increasing evidence suggests that long non-protein-coding RNAs (lncRNAs) are important for the regulation of tissue homeostasis and pathophysiological conditions. Although knowledge about lncRNAs in atherosclerosis and other cardiovascular diseases is sparse, lncRNAs are clinically interesting because of their diagnostic and therapeutic value...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27864543/long-non-coding-rnas-a-novel-paradigm-for-toxicology
#2
REVIEW
Joseph L Dempsey, Julia Yue Cui
Long non-coding RNAs (lncRNAs) are over 200 nucleotides in length and are transcribed from the mammalian genome in a tissue-specific and developmentally regulated pattern. There is growing recognition that lncRNAs are novel biomarkers and/or key regulators of toxicological responses in humans and animal models. Lacking protein-coding capacity, the numerous types of lncRNAs possess a myriad of transcriptional regulatory functions that include cis and trans gene expression, transcription factor activity, chromatin remodeling, imprinting, and enhancer up-regulation...
November 17, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27856459/challenges-and-opportunities-in-linking-long-noncoding-rnas-to-cardiovascular-lung-and-blood-diseases
#3
REVIEW
Jane E Freedman, Joseph M Miano
The new millennium heralds an unanticipated surge of genomic information, most notably an expansive class of long noncoding RNAs (lncRNAs). These transcripts, which now outnumber all protein-coding genes, often exhibit the same characteristics as mRNAs (RNA polymerase II-dependent, 5' methyl-capped, multiexonic, polyadenylated); yet, they do not encode for stable, well-conserved proteins. Elucidating the function of all relevant lncRNAs in heart, vasculature, lung, and blood is essential for generating a complete interactome in these tissues...
November 17, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27789554/lnc-ing-notch1-to-idiopathic-calcific-aortic-valve-disease
#4
EDITORIAL
W David Merryman, Cynthia R Clark
No abstract text is available yet for this article.
December 6, 2016: Circulation
https://www.readbyqxmd.com/read/27753829/sy-03-2-pathophysiologic-significance-of-non-coding-rna-in-hypertension
#5
Stephen Harrap
Genetic discovery in blood pressure is generally referenced in relation to protein-coding genes, despite the fact that genes less than 2% of the genome. Recent exploration of the DNA sequences between genes, once called "junk" DNA, has revealed a wealth of transcripts for RNA species that do not encode protein. These non-coding RNAs (ncRNAs) have emerged as dynamic managers of the business of the genome, able to coordinate the expression of genes in time and space to achieve the complexities of normal development and growth...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642882/sy-03-2-pathophysiologic-significance-of-non-coding-rna-in-hypertension
#6
Stephen Harrap
Genetic discovery in blood pressure is generally referenced in relation to protein-coding genes, despite the fact that genes less than 2% of the genome. Recent exploration of the DNA sequences between genes, once called "junk" DNA, has revealed a wealth of transcripts for RNA species that do not encode protein. These non-coding RNAs (ncRNAs) have emerged as dynamic managers of the business of the genome, able to coordinate the expression of genes in time and space to achieve the complexities of normal development and growth...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27634901/identification-of-long-non-coding-rnas-biomarkers-for-early-diagnosis-of-myocardial-infarction-from-the-dysregulated-coding-non-coding-co-expression-network
#7
Chaoyu Sun, Hao Jiang, Zhiguo Sun, Yifang Gui, Hongyuan Xia
Long non-coding RNAs (lncRNAs) have recently been shown as novel promising diagnostic or prognostic biomarkers for various cancers. However, lncRNA expression patterns and their predictive value in early diagnosis of myocardial infarction (MI) have not been systematically investigated. In our study, we performed a comprehensive analysis of lncRNA expression profiles in MI and found altered lncRNA expression pattern in MI compared to healthy samples. We then constructed a lncRNA-mRNA dysregulation network (DLMCEN) by integrating aberrant lncRNAs, mRNAs and their co-dysregulation relationships, and found that some of mRNAs were previously reported to be involved in cardiovascular disease, suggesting the functional roles of dysregulated lncRNAs in the pathogenesis of MI...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27618485/a-g-rich-motif-in-the-lncrna-braveheart-interacts-with-a-zinc-finger-transcription-factor-to-specify-the-cardiovascular-lineage
#8
Zhihong Xue, Scott Hennelly, Boryana Doyle, Arune A Gulati, Irina V Novikova, Karissa Y Sanbonmatsu, Laurie A Boyer
Long non-coding RNAs (lncRNAs) are an emerging class of transcripts that can modulate gene expression; however, their mechanisms of action remain poorly understood. Here, we experimentally determine the secondary structure of Braveheart (Bvht) using chemical probing methods and show that this ∼590 nt transcript has a modular fold. Using CRISPR/Cas9-mediated editing of mouse embryonic stem cells, we find that deletion of 11 nt in a 5' asymmetric G-rich internal loop (AGIL) of Bvht (bvht(dAGIL)) dramatically impairs cardiomyocyte differentiation...
October 6, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27589064/comprehensive-transcriptome-analyses-of-the-fructose-fed-syrian-golden-hamster-liver-provides-novel-insights-into-lipid-metabolism
#9
Ziyang Li, Chaoliang Xiong, Suo Mo, Haiying Tian, Mengqian Yu, Tingting Mao, Qian Chen, Haitao Luo, Quanzhen Li, Jianxin Lu, Yi Zhao, Wei Li
Dyslipidemia has been widely proven to contribute to cardiovascular diseases and other metabolic disorders, especially in insulin resistance and type 2 diabetes. The overproduction of VLDL is a significant characteristic of dyslipidemia, indicating the dysfunction of hepatic lipid metabolism, from triglyceride synthesis to transport. The fructose-fed Syrian golden hamster is an established animal model for the study of VLDL assembly with insulin resistance, however, it remains unknown how VLDL production is regulated at the transcriptional level due to the absence of a complete hamster genome...
2016: PloS One
https://www.readbyqxmd.com/read/27574949/long-non-coding-rna-hoxc-as1-suppresses-ox-ldl-induced-cholesterol-accumulation-through-promoting-hoxc6-expression-in-thp-1-macrophages
#10
Chuan Huang, Yan-Wei Hu, Jing-Jing Zhao, Xin Ma, Yuan Zhang, Feng-Xia Guo, Chun-Min Kang, Jing-Bo Lu, Jian-Cheng Xiu, Yan-Hua Sha, Ji-Juan Gao, Yan-Chao Wang, Pan Li, Bang-Ming Xu, Lei Zheng, Qian Wang
Atherosclerosis is a common pathological basis of cardiovascular disease, which remains the leading cause of mortality. Long non-coding RNAs (lncRNAs) are newly studied non-protein-coding RNAs involved in gene regulation, but how lncRNAs exert regulatory effect on atherosclerosis remains unclear. In this study, we found that lncRNA HOXC cluster antisense RNA 1 (HOXC-AS1) and homeobox C6 (HOXC6) were downregulated in carotid atherosclerosis by performing microarray analysis. The results were verified in atherosclerotic plaques and normal arterial intima tissues by quantitative reverse transcription PCR and western blot analysis...
August 30, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27569277/nampt-regulates-senescence-proliferation-and-migration-of-endothelial-progenitor-cells-through-the-sirt1-as-lncrna-mir-22-sirt1-pathway
#11
Guang-Feng Ming, Kai Wu, Kai Hu, Yao Chen, Jian Xiao
The importance of endothelial progenitor cells (EPCs) in cardiovascular diseases has been demonstrated by numerous studies. Previous studies have shown that Nicotinamide phosphoribosyltransferase (NAMPT) plays a role in EPC development by regulating Sirtuin 1 (SIRT1), but the specific mechanism has not yet been elucidated. After stimulating EPCs with NAMPT, expression of SIRT1 and SIRT1 antisense long non-coding RNA (AS lncRNA) was upregulated. Upon transfection of an SIRT1 AS lncRNA overexpression vector into EPCs, SIRT1 expression was upregulated...
September 23, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27565812/investigation-of-novel-lps-induced-differentially-expressed-long-non-coding-rnas-in-endothelial-cells
#12
Krishna K Singh, Pratiek N Matkar, Shoaib Muhammad, Adrian Quan, Vijay Gupta, Hwee Teoh, Mohammed Al-Omran, Subodh Verma
The molecular mechanisms responsible for sepsis-induced endothelial dysfunction leading to an elevated risk of cardiovascular diseases remain undefined. Endotoxic or septic shock is a potentially lethal complication of systemic infection by Gram-negative bacteria. Lipopolysaccharide (LPS) is a critical glycolipid component of the outer wall of Gram-negative bacteria, and many of the sepsis-associated cellular signals by Gram-negative bacteria are attributed to LPS. Given that LPS has an established role in the pathophysiology of sepsis and long non-coding RNAs (lncRNAs) have been reported to critically regulate vascular homeostasis, a systematic transcriptional survey was conducted to evaluate the impact of LPS stimulation on human endothelial lncRNAs and protein-coding transcripts (mRNAs)...
October 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27535639/non-coding-rnas-in-development-and-disease-background-mechanisms-and-therapeutic-approaches
#13
REVIEW
Julia Beermann, Maria-Teresa Piccoli, Janika Viereck, Thomas Thum
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-coding transcripts with unknown function. There are several types of non-coding linear RNAs such as microRNAs (miRNA) and long non-coding RNAs (lncRNA), as well as circular RNAs (circRNA) consisting of a closed continuous loop. This review guides the reader through important aspects of non-coding RNA biology. This includes their biogenesis, mode of actions, physiological function, as well as their role in the disease context (such as in cancer or the cardiovascular system)...
October 2016: Physiological Reviews
https://www.readbyqxmd.com/read/27305986/long-noncoding-rna-variations-in-cardiometabolic-diseases
#14
Sariya Dechamethakun, Masaaki Muramatsu
Cardiometabolic diseases are characterized as a combination of multiple risk factors for cardiovascular disease (CVD) and metabolic diseases including diabetes mellitus, dyslipidemia, hypertension and abdominal obesity. This cluster of abnormalities individually and interdependently leads to atherosclerosis and CVD morbidity and mortality. In the past decade, genome-wide association studies (GWASs) have identified a series of cardiometabolic disease-associated variants that can collectively explain a small proportion of the variability...
June 16, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27268316/long-noncoding-rnas-and-their-regulatory-network-potential-therapeutic-targets-for-adult-moyamoya-disease
#15
Faliang Gao, Lanbing Yu, Dong Zhang, Yan Zhang, Rong Wang, Jizong Zhao
OBJECTIVE: To investigate long noncoding ribonucleic acid (lncRNA) expression patterns in adult moyamoya disease (MMD) patients and explore their possible roles in the pathophysiology of MMD. METHODS: A healthy control group (n = 10) and an MMD group (n = 15) were evaluated. RNA was extracted from peripheral blood samples and hybridized to microarray to get lncRNA expression profiles. Then predicted lncRNA target genes were identified, and bioinformatics analysis was performed to investigate their molecular functions...
September 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27144026/investigation-of-tgf%C3%AE-1-induced-long-noncoding-rnas-in-endothelial-cells
#16
Krishna K Singh, Pratiek N Matkar, Adrian Quan, Laura-Eve Mantella, Hwee Teoh, Mohammed Al-Omran, Subodh Verma
Objective. To evaluate the relationship between TGFβ signaling and endothelial lncRNA expression. Methods. Human umbilical vein endothelial cell (HUVECs) lncRNAs and mRNAs were profiled with the Arraystar Human lncRNA Expression Microarray V3.0 after 24 hours of exposure to TGFβ1 (10 ng/mL). Results. Of the 30,584 lncRNAs screened, 2,051 were significantly upregulated and 2,393 were appreciably downregulated (P < 0.05) in response to TGFβ. In the same HUVEC samples, 2,148 of the 26,106 mRNAs screened were upregulated and 1,290 were downregulated...
2016: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/27140855/long-noncoding-rnas-in-kidney-and-cardiovascular-diseases
#17
REVIEW
Johan M Lorenzen, Thomas Thum
Transcription of a large part of the human genome results in RNA transcripts that have limited or no protein-coding potential. These include long noncoding RNAs (lncRNAs), which are defined as being ≥200 nucleotides long. Unlike microRNAs, which have been extensively studied, little is known about the functional role of lncRNAs. However, studies over the past 5 years have shown that lncRNAs interfere with tissue homeostasis and have a role in pathological processes, including in the kidney and heart. The developmental expression of the microRNA sponge H19, for example, is altered in the kidneys of embryos carried by hyperglycaemic mothers, and the lncRNA Malat1 regulates hyperglycaemia-induced inflammation in endothelial cells...
June 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27082978/long-non-coding-rna-ror-mediates-the-reprogramming-in-cardiac-hypertrophy
#18
Feng Jiang, Xiangyu Zhou, Jing Huang
BACKGROUND: Cardiac hypertrophy associated with various cardiovascular diseases results in heart failure and sudden death. A clear understanding of the mechanisms of hypertrophy will benefit the development of novel therapies. Long non-coding RNAs (lncRNAs) have been shown to play essential roles in many biological process, however, whether lncRNA-ROR plays functional roles in the reprogramming of cardiomyocyte remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that lncRNA-ROR plays important roles in the pathogenesis of cardiac hypertrophy...
2016: PloS One
https://www.readbyqxmd.com/read/27049585/long-non-coding-rna-databases-in-cardiovascular-research
#19
REVIEW
Frank Rühle, Monika Stoll
With the rising interest in the regulatory functions of long non-coding RNAs (lncRNAs) in complex human diseases such as cardiovascular diseases, there is an increasing need in public databases offering comprehensive and integrative data for all aspects of these versatile molecules. Recently, a variety of public data repositories that specialized in lncRNAs have been developed, which make use of huge high-throughput data particularly from next-generation sequencing (NGS) approaches. Here, we provide an overview of current lncRNA databases covering basic and functional annotation, lncRNA expression and regulation, interactions with other biomolecules, and genomic variants influencing the structure and function of lncRNAs...
August 2016: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/26965544/long-noncoding-rnas-from-clinical-genetics-to-therapeutic-targets
#20
REVIEW
Reinier A Boon, Nicolas Jaé, Lesca Holdt, Stefanie Dimmeler
Recent studies suggest that the majority of the human genome is transcribed, but only about 2% accounts for protein-coding exons. Long noncoding RNAs (lncRNAs) constitute a heterogenic class of RNAs that includes, for example, intergenic lncRNAs, antisense transcripts, and enhancer RNAs. Moreover, alternative splicing can lead to the formation of circular RNAs. In support of putative functions, GWAS for cardiovascular diseases have shown predictive single-nucleotide polymorphisms in lncRNAs, such as the 9p21 susceptibility locus that encodes the lncRNA antisense noncoding RNA in the INK4 locus (ANRIL)...
March 15, 2016: Journal of the American College of Cardiology
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