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https://www.readbyqxmd.com/read/27882296/white-matter-abnormalities-at-a-regional-and-voxel-level-in-focal-and-generalized-epilepsy-a-systematic-review-and-meta-analysis
#1
Geertruida Slinger, Michel R T Sinke, Kees P J Braun, Willem M Otte
OBJECTIVE: Since the introduction of diffusion tensor imaging, white matter abnormalities in epilepsy have been studied extensively. However, the affected areas reported, the extent of abnormalities and the association with relevant clinical parameters are highly variable. We aimed to obtain a more consistent estimate of white matter abnormalities and their association with clinical parameters in different epilepsy types. METHODS: We systematically searched for differences in white matter fractional anisotropy and mean diffusivity, at regional and voxel level, between people with epilepsy and healthy controls...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27882111/complete-prefrontal-lobe-isolation-surgery-for-recurrent-epilepsy-a-case-report
#2
Shaoya Yin, Weipeng Jin, Qingyun Li, Mei Feng, Keke Feng, Hui Shao, Xueqing Zhang, Shimin Wang
Epileptogenic focus resection is less effective for the treatment of frontal lobe epilepsy compared with temporal lobe epilepsy. However, there is currently a lack of effective therapeutic options for patients with frontal lobe epilepsy who are unsuitable for epileptogenic focus resection (such patients with epileptogenic foci in one frontal lobe in which the precise epileptic foci cannot be determined), or who experience recurrent epilepsy following epileptogenic focus resection. The present study reports a patient with frontal lobe epilepsy who underwent successful frontal lobe isolation surgery following a previous unsuccessful epileptogenic focus resection surgery...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27811355/clinical-and-immunohistochemical-characteristics-of-type-ii-and-type-i-focal-cortical-dysplasia
#3
Kun Yao, Zejun Duan, Jian Zhou, Lin Li, Feng Zhai, Yanting Dong, Xiaoyan Wang, Zhong Ma, Yu Bian, Xueling Qi, Liang Li
Focal cortical dysplasia (FCD) II and I are major causes for drug-resistant epilepsy. In order to gain insight into the possible correlations between FCD II and FCD I, different clinical characteristics and immunohistochemical expression characteristics in FCD I and II were analyzed. The median age of onset and duration of epilepsy in FCD I and FCD II patients were 2.1 years and 5.3 years vs 2.4 years and 4.5 years. Therefore, the median age of onset and duration of epilepsy were similar in the two groups. Pathological lesions were predominantly located in frontal lobe in FCD II and temporal in FCD I...
November 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27799981/meningioangiomatosis-in-an-otherwise-healthy-13-year-old-boy-a-case-report-with-emphasis-on-histopathological-findings
#4
Dorna Motevalli, Naser Kamalian, Seyed Mohammad Tavangar
Meningioangiomatosis is regarded as a rare benign hamartomatous condition mostly involving the cerebral cortex and overlying leptomeninges. A strong association of MA with neurofibromatosis type 2 has been documented in published articles. Herein we report a case of an otherwise healthy 13-year-old boy with no family history or stigmata of neurofibromatosis who presented with intractable seizures. MRI revealed a 2x2 cm mass lesion in the frontal lobe. The patient underwent complete surgical resection of the lesion...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27790124/cerebral-cavernous-malformation-a-portuguese-family-with-a-novel-ccm1-mutation
#5
João Pedro Marto, Inês Gil, Sofia Calado, Miguel Viana-Baptista
INTRODUCTION: Cerebral cavernous malformation (CCM) is a vascular disorder characterized by the presence of central nervous system cavernomas. In familial forms, mutations in three genes (CCM1/KRIT1, CCM2/MGC4607 and CCM3/PDCD10) were identified. We describe a Portuguese family harboring a novel CCM1 mutation. CASE PRESENTATION: The proband is a woman who at the age of 55 years started to have complex partial seizures and episodic headache. Although nothing was found during her neurological examination, brain MRI showed bilateral, supra- and infratentorial cavernomas...
September 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27766665/early-lipofuscin-accumulation-in-frontal-lobe-epilepsy
#6
Joan Yw Liu, Cheryl Reeves, Beate Diehl, Antonietta Coppola, Aliya Al-Hajri, Chandrashekar Hoskote, Salim Al Mughairy, Mohamed Tachrount, Michael Groves, Zuzanna Michalak, Kevin Mills, Andrew W McEvoy, Anna Miserocchi, Sanjay M Sisodiya, Maria Thom
OBJECTIVE: This study reports on a novel brain pathology in young patients with Frontal Lobe Epilepsy that is distinct from Focal Cortical Dysplasia. METHODS: Surgical specimens from twenty young adults with frontal lobe epilepsy (mean age, 30 years) were investigated with histological/immunohistochemical markers for cortical laminar architecture, mammalian target of rapamycin pathway activation and inhibition, cellular autophagy, and synaptic vesicle-mediated trafficking as well as proteomics analysis...
October 20, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27761227/the-chronic-encephalopathy-of-parry-romberg-syndrome-and-en-coupe-de-sabre-with-a-31-year-history-in-a-west-indian-woman-clinical-immunologic-and-neuroimaging-abnormalities
#7
Karan Seegobin, Kamille Abdool, Kanterpersad Ramcharan, Haramnauth Dyaanand, Fidel Rampersad
We describe a case of Parry Romberg syndrome/en coupe de sabre in a woman whose disease started as seizures at age 8 but was diagnosed at the age 39. During these 31 years she got married, completed a first degree at university, had two successful pregnancies and has been gainfully employed. The features of generalized tonic-clonic seizures, autoimmune abnormalities, ocular abnormalities, morphea en coup de sabre and brain imaging abnormalities were present. Areas of parietal lobe cerebral calcification were encountered on the computed tomographic scan and bilateral periventricular white matter changes on the magnetic resonance imaging with frontal, temporal and parietal lobe brain atrophy ipsilateral to the facial hemiatrophy...
September 30, 2016: Neurology International
https://www.readbyqxmd.com/read/27760466/clinical-analysis-and-treatment-of-symptomatic-intracranial-hemorrhage-after-deep-brain-stimulation-surgery
#8
Xin Wang, Jing Wang, Haikang Zhao, Nan Li, Shunnan Ge, Lei Chen, Jiaming Li, Jiangpeng Jing, Mingming Su, Zhaohui Zheng, Jinan Zhang, Guodong Gao, Xuelian Wang
BACKGROUND: Symptomatic intracranial hemorrhage (ICH) may lead to permanent neurological disability of patients and has impeded the extensive clinical application of deep brain stimulation (DBS). The present study was conducted to discuss the incidence, prevention, and treatment of symptomatic ICH after DBS surgery. METHODS: From January 2009 to December 2014, 396 patients underwent DBS with a total of 691 implanted leads. In all, 10 patients had symptomatic ICH...
October 20, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27742374/angiocentric-glioma-transformed-into-anaplastic-ependymoma-review-of-the-evidence-for-malignant-potential
#9
James A McCracken, Michael F Gonzales, Pramit M Phal, Katharine J Drummond
Angiocentric glioma (AG) is a low grade glioma, that was first described in 2002. Since this description, 83 patients with AG have been described, including ours. AG typically presents in childhood with medically refractory seizures that are cured with gross surgical resection. Whilst the natural history is that of a benign tumour, there have been reports of recurrence, transformation, and malignant features that suggest that AG is potentially malignant. We add to the literature a case of a 16-year-old girl who presented in May 2011 with a 3-month history of complex partial seizures, with MRI showing a T2-weighted hyperintense lesion in the left insula and inferior frontal lobe...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27736662/clinical-features-and-postoperative-seizure-outcome-in-patients-with-drug-resistant-gelastic-seizures-without-hypothalamic-hamartoma
#10
Camilo Gutierrez, Ali A Asadi-Pooya, Christopher T Skidmore, Steven D Tobochnik, Carla LoPinto-Khoury, Michael R Sperling
OBJECTIVES: The objective of this study was to describe the clinical characteristics and surgical outcome in patients with gelastic seizures without hypothalamic hamartoma. METHODS: We retrospectively reviewed all the video-EEG reports over a 5-year period (2007-2011) for the occurrence of the terms "laugh" or "giggle" in the text body. All the patients with at least one documented gelastic seizure at the epilepsy monitoring unit were studied. In patients who underwent epilepsy surgery, seizure outcomes were analyzed...
October 10, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27732917/temporal-lobe-origin-is-common-in-patients-who-have-undergone-epilepsy-surgery-for-hypermotor-seizures
#11
Amir M Arain, Nabil J Azar, Andre H Lagrange, Michael McLean, Pradumna Singh, Hasan Sonmezturk, Peter Konrad, Joseph Neimat, Bassel Abou-Khalil
RATIONALE: Hypermotor seizures are most often reported from the frontal lobe but may also have temporal, parietal, or insular origin. We noted a higher proportion of patients with temporal lobe epilepsy in our surgical cohort who had hypermotor seizures. We evaluated the anatomic localization and surgical outcome in patient with refractory hypermotor seizures who had epilepsy surgery in our center. METHODS: We identified twenty three patients with refractory hypermotor seizures from our epilepsy surgery database...
October 9, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27670155/mandibulofacial-dysostosis-with-microcephaly-a-case-presenting-with-seizures
#12
Mari Matsuo, Akemi Yamauchi, Yasushi Ito, Masako Sakauchi, Toshiyuki Yamamoto, Nobuhiko Okamoto, Yoshinori Tsurusaki, Noriko Miyake, Naomichi Matsumoto, Kayoko Saito
We report a case of mandibulofacial dysostosis with microcephaly presenting with seizures. The proband, a 6-year-old Korean boy, had microcephaly, malar and mandibular hypoplasia, and deafness. He showed developmental delay and had suffered recurrent seizures beginning at 21months of age. Electroencephalography revealed occasional spike discharges from the right frontal area. Head magnetic resonance imaging revealed dilatation of the lateral ventricles and a small frontal lobe volume. Whole exome sequencing revealed a de novo frame shift mutation, c...
September 23, 2016: Brain & Development
https://www.readbyqxmd.com/read/27668178/controllable-yawning-expressed-as-focal-seizures-of-frontal-lobe-epilepsy
#13
Vibhangini S Wasade, Indranil Balki, Susan M Bowyer, Shaila Gaddam, Ali-Reza Mohammadi-Nejad, Mohammad-Reza Nazem-Zadeh, Hamid Soltanian-Zadeh, Andrew Zillgitt, Marianna Spanaki-Varelas
Excessive yawning was described in some neurological conditions as part of periictal or ictal manifestations of epilepsy, most commonly temporal lobe. We present the first case of controllable yawning as a primary seizure semiology with dominant frontal lobe involvement in a 20-year-old man. Video electroencephalography recorded 8 yawning episodes accompanied with right arm movement correlating with rhythmic diffuse theta range activity with left hemispheric predominance. Magnetoencephalography coherence source imaging was consistent with persistent neuronal networks with areas of high coherence reliably present over the left lateral orbitofrontal region...
2016: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/27668023/paroxysmal-posterior-variant-alien-hand-syndrome-associated-with-parietal-lobe-infarction-case-presentation
#14
Bekir Enes Demiryürek, Aslı Aksoy Gündogdu, Bilgehan Atılgan Acar, Aybala Neslihan Alagoz
Alien hand syndrome (AHS) is an involuntary and rare neurological disorder emerges at upper extremity. AHS is a disconnection syndrome with the symptoms of losing sense of agency and sense of ownership, and presence of involuntary autonomic motor activity. There are frontal, callosal and posterior types of AHS and each of them occurs depend on the lesions of different of the brain. Posterior variant is a rarely encountered AHS type compared to others. AHS, generally regarded as persistent, but rarely maybe observed as paroxysmal...
October 2016: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/27635114/are-theory-of-mind-skills-in-people-with-epilepsy-related-to-how-stigmatised-they-feel-an-exploratory-study
#15
A J Noble, A Robinson, A G Marson
Feelings of stigma are one of the main burdens reported by people with epilepsy (PWE). Adults with temporal or frontal lobe epilepsy and children with idiopathic generalised epilepsy are at risk of Theory of Mind (ToM) deficits. ToM refers to social cognitive skills, including the ability to understand the thoughts, intentions, beliefs, and emotions of others. It has been proffered that ToM deficits may contribute to the feelings of stigma experienced by PWE. In this study we tested this for the first time...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27630818/fantastic-confabulation-in-right-frontal-lobe-epilepsy
#16
Mayu Fujikawa, Yoshiyuki Nishio, Yosuke Kakisaka, Nanayo Ogawa, Masaki Iwasaki, Nobukazu Nakasato
BACKGROUND: Interictal behavioral symptoms in frontal lobe epilepsy (FLE) are variable and often difficult to discriminate from other localization-related epilepsies. METHODS AND RESULTS: We report two female patients with right FLE who exhibited fantastic confabulations. One of the patients had a 14-year history of hypermotor seizures, and the other had a 10-year history of dyscognitive seizures with automatism. Their fantastic confabulations arose in the context of moderate-to-severe cognitive impairment and of a variety of behavioral abnormalities, including emotional withdrawal and compulsive behaviors...
2016: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/27585993/seizure-control-following-treatment-of-brain-arteriovenous-malformations-in-pediatric-patients
#17
Xiangke Ma, Xianzeng Tong, Jun Wu, Yong Cao, Shuo Wang
PURPOSE: Seizure outcome after treatment for pediatric patients with arteriovenous malformations (AVMs) has been rarely described in the literature. The aim of this study was to determine the risk factors for seizure presentation in pediatric AVM patients and the predictors for seizure control following treatment. METHODS: We searched our characteristics of seizures associated with brain arteriovenous malformations prospectively maintained AVM database at Beijing Tiantan Hospital and identified 198 pediatric patients with brain AVMs between the year 2009 and 2014...
September 1, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27566969/outcomes-of-resective-surgery-in-children-and-adolescents-with-focal-lesional-epilepsy-the-experience-of-a-tertiary-epilepsy-center
#18
Tugba Hirfanoglu, Ayse Serdaroglu, Gokhan Kurt, Atilla Erdem, Irem Capraz, Erhan Bilir, Ozge Vural, Murat Ucar, Ali Yusuf Oner, Baran Onal, Ozgur Akdemir, Ozlem Atay, Ebru Arhan, Kursad Aydin
OBJECTIVE: This study aimed to investigate the efficacy of resective surgery in children with focal lesional epilepsy by evaluating the predictive value of pre- and postsurgical factors in terms of seizure freedom. METHODS: This study included 61 children aged between 2 and 18years who were admitted to the pediatric video-EEG unit for presurgical workup. Each patient was evaluated with a detailed history, video-EEG, neuroimaging, and postsurgical outcomes according to Engel classification to predict postsurgical seizure freedom...
October 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27546337/surgical-resection-for-epilepsy-following-cerebral-gun-shot-wounds
#19
Yoshua Esquenazi, Giridhar P Kalamangalam, Omotola A Hope, Sonia N Krish, Jeremy Slater, Nitin Tandon
OBJECTIVE: The surgical management of epilepsy following penetrating gunshot wounds (GSWs) to the head has not been described in the modern; era. Given the extensive damage to the cranium and cortex from such; injuries, the safety and efficacy of surgical intervention is unclear. We; report the surgical strategy and outcomes following resections for; medically refractory epilepsy following GSWs in four patients. METHODS: A prospectively compiled database of 325 epilepsy patients was used to identify patients undergoing epilepsy surgery for medically; refractory epilepsy following a GSW to the brain...
August 18, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27538609/cortical-thickness-asymmetries-and-surgical-outcome-in-neocortical-epilepsy
#20
David O Kamson, Vinod K Pilli, Eishi Asano, Jeong-Won Jeong, Sandeep Sood, Csaba Juhász, Harry T Chugani
PURPOSE: We evaluated if cortical thickness measures were associated with surgical outcome in patients with non-lesional neocortical epilepsy. METHODS: Twenty-one young patients (age: 2.4-19.7years) with epilepsy of neocortical origin and normal MRI underwent two-stage epilepsy surgery with subdural EEG monitoring. Cortical thickness was measured on presurgical volumetric MRI using the FreeSurfer software. The prognostic value of hemispheric and lobar/regional cortical thickness measures for 1-year and 2-year post-surgical seizure outcome has been analyzed...
September 15, 2016: Journal of the Neurological Sciences
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