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https://www.readbyqxmd.com/read/28431402/micrometastasis-of-endometriosis-to-distant-organs-in-a-murine-model
#1
Elham N Samani, Ramanaiah Mamillapalli, Fei Li, Levent Mutlu, Demetra Hufnagel, Graciela Krikun, Hugh S Taylor
Endometriosis is an inflammatory gynecological disorder among reproductive-aged women caused by the engraftment and proliferation of endometrial cells outside the uterus, most commonly in the pelvis. It is thought that the disease arises primarily from retrograde menstruation where cells from the endometrium travel through the fallopian tubes to the peritoneal cavity. However, migration of endometriosis-derived cells to distant organs outside of the peritoneal cavity have not been explored. In the present study, we developed and validated a mouse model of disseminated endometriosis using syngeneic DsRed endometrial tissue introduced into the peritoneum of immunocompetent mice...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418906/the-associations-of-genetic-polymorphisms-in-cyp1a2-and-cyp3a4-with-clinical-outcomes-of-breast-cancer-patients-in-northern-china
#2
Xianan Bai, Jingjing Xie, Shanshan Sun, Xianyu Zhang, Yongdong Jiang, Da Pang
BACKGROUND: Cytochrome P450 (CYP) 1A2 and CYP3A4 may play a role in the differentiation of clinical outcomes among breast cancer women. This study aimed to analyze the association of genetic polymorphisms in the CYP1A2 and CYP3A4 genes with clinicopathological features, protein expression and prognosis of breast cancer in the northern Chinese population. RESULTS: Firstly, SNP rs11636419, rs17861162 and rs2470890 in the CYP1A2 were significantly associated with age and menstruation status...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417308/treatment-of-menstrual-migraine-multidisciplinary-or-mono-disciplinary-approach
#3
Hester Witteveen, Peter van den Berg, Guus Vermeulen
BACKGROUND: The aim of this study was to compare a multidisciplinary approach of menstrual (related) migraine, combining the neurological and gynaecological consultation, to a mono-disciplinary approach involving neurological treatment. There is a clear relationship between the menstruation cycle and the occurrence of migraine (menstrual migraine). Nowadays the treatment of menstrual (related) migraine is performed by a neurologist. A treatment with attention to hormonal treatment seems more convenient...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28416813/brain-derived-neurotrophic-factor-val-66-met-genotype-and-ovarian-steroids-interactively-modulate-working-memory-related-hippocampal-function-in-women-a-multimodal-neuroimaging-study
#4
S-M Wei, E B Baller, P D Kohn, J S Kippenhan, B Kolachana, S J Soldin, D R Rubinow, P J Schmidt, K F Berman
Preclinical evidence suggests that the actions of ovarian steroid hormones and brain-derived neurotrophic factor (BDNF) are highly convergent on brain function. Studies in humanized mice document an interaction between estrus cycle-related changes in estradiol secretion and BDNF Val(66)Met genotype on measures of hippocampal function and anxiety-like behavior. We believe our multimodal imaging data provide the first demonstration in women that the effects of the BDNF Val/Met polymorphism on hippocampal function are selectively modulated by estradiol...
April 18, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28413306/urogenital-management-in-cloaca-an-alternative-approach
#5
Harshjeet Singh Bal, Sudipta Sen, Cenita Sam, Jacob Chacko, John Mathai, S R Regunandan
INTRODUCTION: In the management of cloaca, there is concern that dissection of the urogenital sinus in early childhood with the aim of total anatomical correction is hazardous. Avoiding such mobilization and providing mitrofanoff channel, when needed, till peripubertal period reduces complications and is technically easier. MATERIALS AND METHODS: Forty-three cases of cloaca were managed in the period 2004-2016. Case records and radiology were reviewed retrospectively...
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28410414/phthalate-exposure-and-reproductive-hormones-and-sex-hormone-binding-globulin-before-puberty-phthalate-contaminated-foodstuff-episode-in-taiwan
#6
Hui-Ju Wen, Chu-Chih Chen, Ming-Tsang Wu, Mei-Lien Chen, Chien-Wen Sun, Wen-Chiu Wu, I-Wen Huang, Po-Chin Huang, Tzu-Yun Yu, Chao A Hsiung, Shu-Li Wang
BACKGROUND: In May 2011, a major incident involving phthalates-contaminated foodstuffs occurred in Taiwan. Di-(2-ethylhexyl) phthalate (DEHP) was added to foodstuffs, mainly juice, jelly, tea, sports drink, and dietary supplements. Concerns arose that normal pubertal development, especially reproductive hormone regulation in children, could be disrupted by DEHP exposure. OBJECTIVE: To investigate the association between phthalate exposure and reproductive hormone levels among children following potential exposure to phthalate-tainted foodstuffs...
2017: PloS One
https://www.readbyqxmd.com/read/28409025/the-impact-of-the-menstrual-cycle-on-perioperative-bleeding-in-vitreoretinal-surgery
#7
Zhong Lin, Nived Moonasar, Rong Han Wu, Robin R Seemongal-Dass
Purpose. To investigate the effect of menstrual cycle on perioperative bleeding of primary vitreoretinal surgery. Methods. Data on female patients who had vitrectomy surgery was retrospectively collected. Exclusion criteria were history of trauma, vitreous hemorrhage, previous vitreoretinal surgery, diabetic retinopathy, endophthalmitis, acute retinal necrosis, single vitreous opacity, and use of antiplatelet agents. Perioperative bleeding was defined as hemorrhage in the iris, vitreous, choroidal, retina, or subretina during surgery or up to one day postoperatively...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28406763/do-women-with-fibromyalgia-present-higher-cardiovascular-disease-risk-profile-than-healthy-women-the-al-%C3%A3-ndalus-project
#8
Pedro Acosta-Manzano, Víctor Segura-Jiménez, Fernando Estévez-López, Inmaculada C Álvarez-Gallardo, Alberto Soriano-Maldonado, Milkana Borges-Cosic, Blanca Gavilán-Carrera, Manuel Delgado-Fernández, Virginia A Aparicio
OBJECTIVES: To analyse the cardiovascular disease risk profile of women with fibromyalgia and compare it with control women; and to test whether physical activity is associated with the cardiovascular disease risk profile in this population. METHODS: This cross-sectional study comprised 436 women with fibromyalgia (51.4±7.5 years old) and 217 controls (48.4±9.6 years old) from Andalusia, Spain. Clinical data, waist circumference, body fat percentage, resting heart rate, blood pressure and cardiorespiratory fitness were assessed...
April 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28402199/from-menarche-to-menopause-understanding-multigenerational-reproductive-health-milestones
#9
Kimberly Field-Springer, Deleasa Randall-Griffiths, Carol Reece
Our study aims at understanding multigenerational communication among grandmothers, mothers, and daughters experiencing reproductive health transitions from menarche to menopause. Thirty women, 10 triads of grandmothers, mothers, and daughters, participated in narrative interviews to recount their menarche and menopause experiences. Analysis was read using a multilayered approach to interpret discourse positioned from self, reflexive others, and those stories informed by societal meanings. Four dialectical themes informed by generational discursive shifts in talk included (1) covert versus overt talk, (2) recollection of versus indifference to menarche, (3) bound to versus freedom from menstruation, and (4) controlling versus managing bodily changes...
April 12, 2017: Health Communication
https://www.readbyqxmd.com/read/28397357/submaximal-doses-of-ghrelin-do-not-inhibit-gonadotrophin-levels-but-stimulate-prolactin-secretion-in-postmenopausal-women
#10
C I Messini, M Malandri, G Anifandis, K Dafopoulos, P Georgoulias, G Sveronis, A Garas, A Daponte, I E Messinis
OBJECTIVE: An inhibitory effect of ghrelin on gonadotrophin secretion has been reported in normally menstruating women possibly modulated by endogenous estrogen. The aim of this study was to examine the effect of ghrelin on gonadotrophin and PRL secretion in estrogen-deprived postmenopausal women. DESIGN: Prospective intervention study. PATIENTS AND MEASUREMENTS: Ten healthy postmenopausal volunteer women were studied during two 15-day periods of estrogen treatment (A and B) a month apart...
April 11, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28393811/a-cross-sectional-clinical-study-to-evaluate-mobility-of-teeth-during-pregnancy-using-periotest
#11
Poonam Sujeet Mishra, Pramod P Marawar, Sunil Surendraprasad Mishra
BACKGROUND AND OBJECTIVE: Over a century, an increased prevalence of gingival diseases associated with increasing plasma sex steroid hormone levels has been reported. These situations present unique challenges to the oral health-care professional. It is believed that hormonal fluctuations such as those associated with pregnancy, menstruation, and use of hormonal contraceptives lead to an increase in tooth mobility. However, this effect of female sex hormones on periodontal ligament and tooth-supporting alveolar bone has rarely been investigated...
January 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28391664/effect-of-green-tea-added-tablets-on-volatile-sulfur-containing-compounds-in-the-oral-cavity
#12
Pier Francesco Porciani, Simone Grandini
OBJECTIVES: A controlled, clinical, double-blind, cross-over study was conducted to assess the efficacy of sugar-free tablets containing green tea extract on oral volatile sulfur-containing compounds (VSC) versus placebo tablets for 30 minutes. METHODS: To join the study, subjects had to have at least 24 teeth, no report of oral and systemic diseases, and no removable dentures. All eligible participants had to avoid professional oral hygiene and drugs for two weeks, to not be menstruating, to avoid brushing their teeth and tongue, to not smoke, to not consume alcohol, coffee or tea, nor onion, garlic, or licorice for six hours before the test...
December 2016: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/28388882/an-abdominal-ectopic-pregnancy-following-a-frozen-thawed-art-cycle-a-case-report-and-review-of-the-literature
#13
Atsushi Yanaihara, Shirei Ohgi, Kenichirou Motomura, Yuko Hagiwara, Tae Mogami, Keisuke Saito, Takumi Yanaihara
BACKGROUND: Ectopic pregnancy (EP) occurs in 1% of pregnancies and is reported to be more common in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) pregnancies. An abdominal ectopic pregnancy (AEP) is a rare form of EP, and there are few reports of an AEP after IVF/ICSI. In this case report, a rare case of AEP after frozen-thawed cycle of ICSI is presented. CASE PRESENTATION: After a frozen-thawed cycle of ICSI, the beta-human chorionic gonadotropin (HCG) level at 4 weeks 0 days of gestation was 3...
April 7, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28388727/progesterone-receptors-and-proliferation-of-the-endometrium-in-obese-women-with-polycystic-ovary-syndrome-a-lifestyle-intervention-study
#14
Mariana Paulson, Lena Sahlin, Angelica Lindén Hirschberg
Context: Polycystic ovary syndrome (PCOS) is associated with increased risk of endometrial cancer. This is usually explained by chronic anovulation and deficient progesterone activity. However, the role of progesterone receptors (PRs) in endometrial proliferation is unclear. Objective: To evaluate PRs in relation to endometrial proliferation in women with PCOS. Design: Cross-sectional study and lifestyle intervention. Setting: Clinical and laboratory research unit at a university hospital...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28382099/fertility-rates-in-young-korean-breast-cancer-patients-treated-with-gonadotropin-releasing-hormone-and-chemotherapy
#15
Isaac Kim, Jai Min Ryu, Hyun-June Paik, Sungmin Park, Soo Youn Bae, Se Kyung Lee, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee
PURPOSE: Gonadotropin-releasing hormone (GnRH) agonists have been used with adjuvant chemotherapy to protect ovarian function. However, there are no data on the actual pregnancy rates among young breast cancer patients receiving GnRH agonists and concurrent chemotherapy in Korea. METHODS: Among patients who underwent surgery from January 2002 to April 2012, premenopausal patients aged between 20 and 40 years were included in the analysis. We retrospectively reviewed clinicopathologic features (e...
March 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28378984/impact-of-spinal-pain-on-daily-living-activities-in-postmenopausal-women-working-in-agriculture
#16
Dorota Raczkiewicz, Alfred Owoc, Beata Sarecka-Hujar, Tomasz Saran, Iwona Bojar
INTRODUCTION AND OBJECTIVE: Postmenopausal women working in agriculture suffer from spinal pain for two overlapping reasons, the first is related to the menopause and the second to the specificity of rural work, which includes lifting heavy objects and changing weather conditions. Spinal pain affects the daily life of women as well as their ability to work. The objective of the study was to analyse the impact of spinal pain on activities of daily life in Polish postmenopausal women performing agricultural work...
March 22, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28372870/analysis-of-outcomes-and-prognostic-factors-after-fertility-sparing-surgery-in-malignant-ovarian-germ-cell-tumors
#17
Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: To evaluate the oncologic and reproductive outcomes and to analyze prognostic factors after fertility-sparing surgery in patients with early and advanced malignant ovarian germ cell tumors (MOGCTs). METHODS: This study included 171 patients who underwent fertility-sparing surgery. Data were gathered from patients' medical records. Survival analysis was performed using the log-rank test and Cox's proportional hazards model. Reproductive outcomes were analyzed...
March 31, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28372526/adjunctive-metformin-for-antipsychotic-related-hyperprolactinemia-a-meta-analysis-of-randomized-controlled-trials
#18
Wei Zheng, Xin-Hu Yang, Dong-Bin Cai, Gabor S Ungvari, Chee H Ng, Nan Wang, Yu-Ping Ning, Yu-Tao Xiang
Hyperprolactinemia is a common and severe antipsychotic-induced adverse drug reaction. This meta-analysis of randomized controlled trials systematically examined the efficacy and safety of adjunctive metformin for antipsychotic-related hyperprolactinemia in schizophrenia patients. Two independent investigators searched, extracted, and synthesized data. Weighted mean differences and risk ratios with their 95% confidence intervals were calculated using random effect model. Four randomized controlled trials ( n=509) comparing adjunctive metformin ( n=253) with the control groups ( n=256), lasting 22...
March 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28371283/outcomes-in-patients-undergoing-robotic-reconstructive-uterovaginal-anastomosis-of-congenital-cervical-and-vaginal-atresia
#19
Ying Zhang, Yisong Chen, Keqin Hua
OBJECTIVE: To introduce our experience of robotic surgery of reconstructive uterovaginal anastomosis and operative outcomes in congenital cervical and vaginal atresia patients. METHODS: Clinical observation and follow-up of four patients with congenital cervical and vaginal atresia who underwent robotic reconstruction of cervix and vagina by SIS (small intestinal submucosa, SIS) graft. RESULTS: Average patient age was 13.8 ± 2.2. Patients complained of severe periodic abdominal pain...
March 29, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28367303/follicle-stimulating-hormone-and-anti-m%C3%A3-llerian-hormone-among-fertile-and-infertile-women-in-ile-ife-nigeria-is-there-a-difference
#20
Temitope Okunola, Kayode Olusegun Ajenifuja, Olabisi Morebise Loto, Afolabi Salawu, Stephen Oluseyi Omitinde
BACKGROUND: Reduced ovarian reserve predicts poor ovarian response and poor suc- cess rates in infertile women who undergo assisted reproductive technology (ART). Ovarian reserve also decreases with age but the rate of decline varies from one woman to another. This study aims to detect differences in ovarian reserve as measured by basal serum follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH) between a matched cohort of fertile and infertile regularly menstruating women, 18-45 years of age...
April 2017: International Journal of Fertility & Sterility
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