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https://www.readbyqxmd.com/read/29332135/sequential-versus-simultaneous-use-of-chemotherapy-and-gonadotropin-releasing-hormone-agonist-gnrha-among-estrogen-receptor-er-positive-premenopausal-breast-cancer-patients-effects-on-ovarian-function-disease-free-survival-and-overall-survival
#1
Ying Zhang, Yajie Ji, Jianwei Li, Li Lei, Siyu Wu, Wenjia Zuo, Xiaoqing Jia, Yujie Wang, Miao Mo, Na Zhang, Zhenzhou Shen, Jiong Wu, Zhimin Shao, Guangyu Liu
OBJECTIVE: To investigate ovarian function and therapeutic efficacy among estrogen receptor (ER)-positive, premenopausal breast cancer patients treated with gonadotropin-releasing hormone agonist (GnRHa) and chemotherapy simultaneously or sequentially. METHOD: This study was a phase 3, open-label, parallel, randomized controlled trial (NCT01712893). Two hundred sixteen premenopausal patients (under 45 years) diagnosed with invasive ER-positive breast cancer were enrolled from July 2009 to May 2013 and randomized at a 1:1 ratio to receive (neo)adjuvant chemotherapy combined with sequential or simultaneous GnRHa treatment...
January 13, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29332111/prevalence-of-menstrual-problems-and-their-association-with-psychological-stress-in-young-female-students-studying-health-sciences
#2
Nazish Rafique, Mona H Al-Sheikh
To identify the prevalence of various menstrual problems in young females studying health sciences and to identify their association with academic stress. Methods: This was a cross-sectional study, conducted in the health colleges of Immam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia between February 2015 and February 2016. Seven hundred and thirty-eight female students aged 18-25 years anonymously completed menstrual problem identification and perceived stress scale questionnaire. The data was analyzed using the Statistical Package for Social Sciences version 16...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29325133/the-efficacy-of-24-month-metformin-for-improving-menses-hormone-and-metabolic-profiles-in-polycystic-ovary-syndrome
#3
Po-Kai Yang, Chih-Yuan Hsu, Mei-Jou Chen, Mei-Yu Lai, Zheng-Rong Li, Chen-Hsin Chen, Shee-Uan Chen, Hong-Nerng Ho
Context: The long-term effects of metformin in women with polycystic ovarian syndrome (PCOS) are inadequately studied. Objective: The effects of metformin on women with PCOS over 24-month with respect to menses, hormones and metabolic profiles are assessed. Design: Prospective cohort. Setting: A reproductive endocrinology clinic in a university-affiliated medical center. Patients: 119 women with PCOS, defined by the Rotterdam criteria, were enrolled...
January 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29320327/atypical-sites-of-deeply-infiltrative-endometriosis-clinical-characteristics-and-imaging-findings
#4
Luciana P Chamié, Duarte Miguel Ferreira Rodrigues Ribeiro, Dario A Tiferes, Augusto Cesar de Macedo Neto, Paulo C Serafini
Endometriosis is defined as the presence of endometrial tissue that is located outside the uterine cavity and associated with fibrosis and inflammatory reaction. It is a polymorphic and multifocal disease with no known cure or preventive mechanisms. Patients may be asymptomatic or may experience chronic pelvic pain, dysmenorrhea, dyspareunia, or infertility. The pelvic cavity is the most common location for endometriotic implants, which usually affect the retrocervical space, ovaries, vagina, rectosigmoid colon, bladder dome, and round ligaments...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29317075/the-origin-of-endometriosis-associated-ovarian-cancer-from-uterine-neoplastic-lesions
#5
Elisabetta Garavaglia, Cristina Sigismondi, Stefano Ferrari, Massimo Candiani
Endometriosis is a risk factor for type I epithelial ovarian cancer but an issue to be clarified is the site of origin of endometriosis associated ovarian cancer. Here we proposed that the uterus may be the organ of origin of ovarian endometrioid cancer associated with endometriosis. Thus, the first neoplastic transformation would characterize the uterine cells migrating in the pelvis via retrograde menstruation and they would implant secondarily on the ovary. Supporting this hypothesis, an higher incidence of synchronous precancerous and cancerous endometrial pathology in patients affected by ovarian endometrioid cancer associated with endometriosis was showed...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29316073/involvement-of-immune-cells-in-the-pathogenesis-of-endometriosis
#6
Gentaro Izumi, Kaori Koga, Masashi Takamura, Tomoko Makabe, Erina Satake, Arisa Takeuchi, Ayumi Taguchi, Yoko Urata, Tomoyuki Fujii, Yutaka Osuga
Endometriosis is characterized by the implantation and growth of endometriotic tissues outside the uterus. It is widely accepted the theory that endometriosis is caused by the implantation of endometrial tissue from retrograde menstruation; however, retrograde menstruation occurs in almost all women and other factors are required for the establishment of endometriosis, such as cell survival, cell invasion, angiogenesis, and cell growth. Immune factors in the local environment may, therefore, contribute to the formation and progression of endometriosis...
January 5, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29313762/development-and-psychometric-validation-of-the-menstrual-health-instrument-mhi-for-adolescents-in-korea
#7
Hyunjeong Shin, Young-Joo Park, Inhae Cho
The aims of the researchers were to develop and test initial psychometric properties of the Menstrual Health Instrument, a measure of menstrual health in adolescents that comprehensively evaluates menstrual health. Data were collected with a convenience sample of 230 Korean adolescent girls. As a result of exploratory factor analysis with the 29-item instrument, five factors were extracted: affective symptoms, somatic symptoms and school life, daily habits for menstrual health, menstrual cycle characteristics, and attitudes and perceptions on menstruation...
January 9, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29310409/analysis-of-diagnosis-and-treatment-of-complicated-cervical-severe-adhesion-atresia-after-removal-of-endometrial-stromal-nodule-a-case-report
#8
Rui Zhang, Pei Gu, Qi Liu, Bin Li, Wenpei Bai
RATIONALE: Endometrial stromal nodule (ESN) is a rare benign endometrial stroma tumor.Experiences are helpful for avoiding and treating similar postoperative complications (cervical adhesions and atresia). PATIENT CONCERNS: When appearing in the cervical, this tumor can easily lead to complications after the surgical resection. The diagnosis and postsurgery complication of a young woman's ESN was reported here. DIAGNOSES: The postoperative pathological diagnosis was ESN...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29306980/sex-in-respiratory-and-skin-allergies
#9
REVIEW
Erminia Ridolo, Cristoforo Incorvaia, Irene Martignago, Marco Caminati, Giorgio Walter Canonica, Gianenrico Senna
A bulk of literature demonstrated that respiratory allergy, and especially asthma, is prevalent in males during childhood, while it becomes more frequent in females from adolescence, i.e., after menarche, to adulthood. The mechanisms underlying the difference between females and males are the effects on the immune response of female hormones and in particular the modulation of inflammatory response by estrogens, as well as the result of the activity of various cells, such as dendritic cells, innate lymphoid cells, Th1, Th2, T regulatory (Treg) and B regulatory (Bregs) cells, and a number of proteins and cytokines, which include interleukin (IL)-4, IL-5, IL-10, and IL-13...
January 6, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29305663/investigation-of-auditory-potentials-and-cognitive-impairment-in-premenstrual-syndrome
#10
Ceyda Hayretdag Ors, Handan Işin Ozisik Karaman
Premenstrual syndrome is a term which is used for describing of somatic, cognitive, emotional, and behavioral symptoms that occur during the luteal phase of menstrual cycle in women of reproductive age; symptoms rapidly improve at the onset of menstruation. In this study, we aimed to reveal if cognitive functions are affected or not in PMS and if the subjects are affected, we try to explain this situation by an objective diagnostic test. Ethical committee approval was taken for this project on 09.03.2012 and numbered 050...
January 5, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29302548/a-descriptive-cross-sectional-study-on-menstrual-hygiene-and-perceived-reproductive-morbidity-among-adolescent-girls-in-a-union-territory-india
#11
Prakash Mathiyalagen, Birundhanjali Peramasamy, Kavita Vasudevan, Mausumi Basu, Johnson Cherian, Buvaneshwari Sundar
Introduction: Menstruation is a milestone event in a girl's life and the beginning of reproductive life. Lack of knowledge and poor sanitary practices during menstruation has been associated with serious ill-health ranging from genital tract infections, urinary tract infections, and bad odor. Aim: This study aims to explore the knowledge, attitude, and practices about menstrual hygiene and perceived reproductive morbidity among adolescent school girls in Puducherry...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29300932/endometrial-stromal-cell-attachment-and-matrix-homeostasis-in-abdominal-wall-endometriomas
#12
Hiroko Itoh, Haruta Mogami, Laurice Bou Nemer, Larry Word, David Rogers, Rodney Miller, R Ann Word
STUDY QUESTION: How does progesterone alter matrix remodeling in abdominal wall endometriomas compared with normal endometrium? SUMMARY ANSWER: Progesterone may prevent attachment of endometrial cells to the abdominal wall, but does not ameliorate abnormal stromal cell responses of abdominal wall endometriomas. WHAT IS KNOWN ALREADY: Menstruation is a tightly orchestrated physiologic event in which steroid hormones and inflammatory cells cooperatively initiate shedding of the endometrium...
December 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29298699/menstrual-health-and-school-absenteeism-among-adolescent-girls-in-uganda-meniscus-a-feasibility-study
#13
George Miiro, Rwamahe Rutakumwa, Jessica Nakiyingi-Miiro, Kevin Nakuya, Saidat Musoke, Juliet Namakula, Suzanna Francis, Belen Torondel, Lorna J Gibson, David A Ross, Helen A Weiss
BACKGROUND: Management of menstruation can present substantial challenges to girls in low-income settings. In preparation for a menstrual hygiene intervention to reduce school absenteeism in Uganda, this study aimed to investigate menstruation management practices, barriers and facilitators, and the influence of menstruation on school absenteeism among secondary school students in a peri-urban district of Uganda. METHODS: Qualitative and quantitative studies were conducted among consenting girls and boys aged 14-17 years in four secondary schools in Entebbe sub-District, Uganda...
January 3, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29283683/period-prevalence-and-perceived-side-effects-of-hormonal-contraceptive-use-and-the-menstrual-cycle-in-elite-athletes
#14
Daniel Martin, Craig Sale, Simon B Cooper, Kirsty J Elliott-Sale
PURPOSE: To identify the period prevalence of hormonal contraceptive (HC) use and characterise the perceived side effects associated with the menstrual cycle and HC use. METHODS: 430 elite female athletes completed a questionnaire to assess; the period prevalence of HC use, the reasons for initiation and discontinuation of HCs and the side effects experienced by HC and non-HC users. Descriptive statistics, between-group comparisons and associations between categorical variables were calculated...
December 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29280410/iron-balance-and-iron-supplementation-for-the-female-athlete-a-practical-approach
#15
Charles R Pedlar, Carlo Brugnara, Georgie Bruinvels, Richard Burden
Maintaining a positive iron balance is essential for female athletes to avoid the effects of iron deficiency and anaemia and to maintain or improve performance. A major function of iron is in the production of the oxygen and carbon dioxide carrying molecule, haemoglobin, via erythropoiesis. Iron balance is under the control of a number of factors including the peptide hormone hepcidin, dietary iron intake and absorption, environmental stressors (e.g. altitude), exercise, menstrual blood loss and genetics. Menstruating females, particularly those with heavy menstrual bleeding are at an elevated risk of iron deficiency...
December 27, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/29275276/fragile-x-associated-premature-ovarian-failure-in-a-large-turkish-cohort-findings-of-hacettepe-fragile-x-registry
#16
Gülen Eda Utine, Pelin Özlem Şimşek-Kiper, Özlem Akgün-Doğan, Gizem Ürel-Demir, Yasemin Alanay, Dilek Aktaş, Koray Boduroğlu, Ergül Tunçbilek, Mehmet Alikaşifoğlu
OBJECTIVE: To determine frequency of fragile X associated premature ovarian insufficiency (FXPOI) among Turkish premutation carriers. STUDY DESIGN: FMR1 premutation is the single most common genetic cause of POI (FXPOI). Fragile X Registry at Hacettepe University has been reviewed for the frequency of FXPOI among female premutation carriers. Since 1991 when FMR1 testing was available, 760 individuals from 243 families have been registered. Actual data on menstrual status of female premutation carriers were gathered and analysed...
December 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29259477/weight-reduction-using-a-formula-diet-recovers-menstruation-in-obese-patients-with-an-ovulatory-disorder
#17
Toshiya Matsuzaki, Tsutomu Douchi, Toshimichi Oki, Osamu Ishihara, Ryugo Okagaki, Takeshi Kajihara, Midori Tamura, Fumikazu Kotsuji, Kimihisa Tajima, Mika Kawano, Bunpei Ishizuka, Minoru Irahara
Aim: To determine the effectiveness of a formula diet in weight reduction and the recovery of menstruation in obese patients with ovulatory disorders. Methods: After the enrollment of 39 obese women with ovulatory disorders, they replaced one or two of their three normal meals with a microdiet (MD) (240 kcal/meal) for 24 weeks. Physical, endocrinological, and biochemical tests were conducted before and at 12 and 24 weeks of the study. Of the 39 women enrolled, 26 were not taking clomiphene...
July 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29259453/polycystic-ovary-syndrome-early-diagnosis-and-intervention-are-necessary-for-fertility-preservation-in-young-women-with-endometrial-cancer-under-35%C3%A2-years-of-age
#18
Yoshinori Okamura, Fumitaka Saito, Kiyomi Takaishi, Takeshi Motohara, Ritsuo Honda, Takashi Ohba, Hidetaka Katabuchi
Aim: Polycystic ovary syndrome (PCOS) is a significant risk factor for premenopausal endometrial cancer (EC) and/or atypical endometrial hyperplasia (AEH). The aim was to elucidate the clinical background and detailed menstrual history of EC and/or AEH in young women with PCOS. Methods: From January 2001 to December 2013, women under 35 years of age who had been diagnosed with EC and/or AEH and who had been treated at Kumamoto University Hospital, Japan, were recruited...
January 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29259057/influencing-factors-of-dysmenorrhoea-among-hospital-nurses-a-questionnaire-survey-in-taiwan
#19
Min-Hui Chiu, Hsiu-Fen Hsieh, Yi-Hsin Yang, Huei-Mein Chen, Su-Chen Hsu, Hsiu-Hung Wang
OBJECTIVES: Nurses are at high risk of dysmenorrhoea while working with patients. The study objectives were to: (1) describe the demographic and menstruation characteristics of dysmenorrhoea, knowledge about dysmenorrhoea and menstrual attitudes towards menstruation among dysmenorrhoeal and non-dysmenorrhoeal hospital nurses; (2) identify significant differences between the groups; and (3) examine factors influencing dysmenorrhoea. METHODS: This cross-sectional survey used a structured questionnaire, administered at two hospitals in southern Taiwan...
December 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/29259032/analysis-of-chromatin-accessibility-in-decidualizing-human-endometrial-stromal-cells
#20
Pavle Vrljicak, Emma S Lucas, Lauren Lansdowne, Raffaella Lucciola, Joanne Muter, Nigel P Dyer, Jan J Brosens, Sascha Ott
Spontaneous decidualization of the endometrium in response to progesterone signaling is confined to menstruating species, including humans and other higher primates. During this process, endometrial stromal cells (EnSCs) differentiate into specialized decidual cells that control embryo implantation. We subjected undifferentiated and decidualizing human EnSCs to an assay for transposase accessible chromatin with sequencing (ATAC-seq) to map the underlying chromatin changes. A total of 185,084 open DNA loci were mapped accurately in EnSCs...
December 19, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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