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https://www.readbyqxmd.com/read/27930283/mortality-in-the-united-states-2015
#1
Jiaquan Xu, Sherry L Murphy, Kenneth D Kochanek, Elizabeth Arias
Data from the National Vital Statistics System, Mortality •Life expectancy for the U.S. population in 2015 was 78.8 years, a decrease of 0.1 year from 2014. •The age-adjusted death rate increased 1.2% from 724.6 deaths per 100,000 standard population in 2014 to 733.1 in 2015. •The 10 leading causes of death in 2015 remained the same as in 2014. Age-adjusted death rates increased for eight leading causes and decreased for one. •The infant mortality rate of 589.5 infant deaths per 100,000 live births in 2015 was not significantly different from the 2014 rate...
December 2016: NCHS Data Brief
https://www.readbyqxmd.com/read/27928187/impact-of-a-training-program-on-pharmacists-comfort-with-pediatric-pharmacy-concepts-and-basic-pediatric-knowledge
#2
Elizabeth A Riney, Andrew J Crannage, Nausheen Hasan, Julie A Murphy
Objective: To determine the impact of a training program on pharmacists' comfort with pediatric pharmacy concepts and basic pediatric knowledge. Methods: All pharmacists at our institution were invited to participate in the study. Consenting participants completed a baseline survey of 15 questions on basic knowledge in 5 pediatric topic areas (pharmacokinetics/pharmacodynamics, weight-based dosing, anticoagulation, renal dosing, and common antibiotics) as well as 8 statements rating self-reported comfort with pediatric pharmacy...
November 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27911489/palliative-care-interventions-in-advanced-dementia
#3
REVIEW
Edel Murphy, Katherine Froggatt, Sheelah Connolly, Eamon O'Shea, Elizabeth L Sampson, Dympna Casey, Declan Devane
BACKGROUND: Dementia is a chronic, progressive and ultimately fatal neurodegenerative disease. Advanced dementia is characterised by profound cognitive impairment, inability to communicate verbally and complete functional dependence. Usual care of people with advanced dementia is not underpinned universally by a palliative approach. Palliative care has focused traditionally on care of people with cancer but for more than a decade, there have been increased calls worldwide to extend palliative care services to include all people with life-limiting illnesses in need of specialist care, including people with dementia...
December 2, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27908787/fractionating-the-anterior-temporal-lobe-mvpa-reveals-differential-responses-to-input-and-conceptual-modality
#4
Charlotte Murphy, Shirley-Ann Rueschemeyer, David Watson, Theodoros Karapanagiotidis, Jonathan Smallwood, Elizabeth Jefferies
Words activate cortical regions in accordance with their modality of presentation (i.e., written vs. spoken), yet there is a long-standing debate about whether patterns of activity in any specific brain region capture modality-invariant conceptual information. Deficits in patients with semantic dementia highlight the anterior temporal lobe (ATL) as an amodal store of semantic knowledge but these studies do not permit precise localisation of this function. The current investigation used multiple imaging methods in healthy participants to examine functional dissociations within ATL...
November 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27908218/risk-factors-for-dural-tears-a-study-of-elective-spine-surgery
#5
Meghan E Murphy, Panagiotis Kerezoudis, Mohammed Ali Alvi, Brandon A McCutcheon, Patrick R Maloney, Lorenzo Rinaldo, Daniel Shepherd, Daniel S Ubl, William E Krauss, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE: This study moves beyond previous cohort studies and benchmark data by studying a population of elective spine surgery from a multicenter registry in an effort to validate, disprove, and/or identify novel risk factors for dural tears. METHODS: A retrospective cohort analysis queried a multicenter registry for patients with degenerative spinal diagnoses undergoing elective spinal surgery from 2010-2014. Multivariable logistic regression analysis interrogated for independent risk factors of dural tears...
December 2, 2016: Neurological Research
https://www.readbyqxmd.com/read/27901460/anesthesia-case-of-the-month
#6
Elizabeth M Goudie-DeAngelis, Erin L Wendt-Hornickle, Daniel C Almeida, Lindsey A Murphy, Lynelle F Graham
No abstract text is available yet for this article.
December 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27899525/reactive-oxygen-species-induce-virus-independent-mavs-oligomerization-in-systemic-lupus-erythematosus
#7
Iwona A Buskiewicz, Theresa Montgomery, Elizabeth C Yasewicz, Sally A Huber, Michael P Murphy, Richard C Hartley, Ryan Kelly, Mary K Crow, Andras Perl, Ralph C Budd, Andreas Koenig
The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with retinoic acid gene I (RIG-I)-like helicases during viral infection, was activated by oxidative stress independently of RIG-I helicases. We found that chemically generated oxidative stress stimulated the formation of MAVS oligomers, which led to mitochondrial hyperpolarization and decreased adenosine triphosphate production and spare respiratory capacity, responses that were not observed in similarly treated cells lacking MAVS...
November 29, 2016: Science Signaling
https://www.readbyqxmd.com/read/27869097/the-impact-of-radiation-treatment-time-on-survival-in-patients-with-head-and-neck-cancer
#8
Talha Shaikh, Elizabeth A Handorf, Colin T Murphy, Ranee Mehra, John A Ridge, Thomas J Galloway
PURPOSE: To assess the impact of radiation treatment time (RTT) in head and neck cancers on overall survival (OS) in the era of chemoradiation. METHODS AND MATERIALS: Patients with diagnoses of tongue, hypopharynx, larynx, oropharynx, or tonsil cancer were identified by use of the National Cancer Database. RTT was defined as date of first radiation treatment to date of last radiation treatment. In the definitive setting, prolonged RTT was defined as >56 days, accelerated RTT was defined as <47 days, and standard RTT was defined as 47 to 56 days...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27866034/micro-vs-macrodiscectomy-does-use-of-the-microscope-reduce-complication-rates
#9
Meghan E Murphy, Jeffrey S Hakim, Panagiotis Kerezoudis, Mohammed Ali Alvi, Daniel S Ubl, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE: A single level discectomy is one of the most common procedures performed by spine surgeons. While some practitioners utilize the microscope, others do not. We postulate improved visualization with an intraoperative microscope decreases complications and inferior outcomes. METHODS: A multicenter surgical registry was utilized for this retrospective cohort analysis. Patients with degenerative spinal diagnoses undergoing elective single level discectomies from 2010 to 2014 were included...
November 13, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27858534/lumbar-decompression-in-the-elderly-increased-age-as-a-risk-factor-for-complications-and-nonhome-discharge
#10
Meghan E Murphy, Hannah Gilder, Patrick R Maloney, Brandon A McCutcheon, Lorenzo Rinaldo, Daniel Shepherd, Panagiotis Kerezoudis, Daniel S Ubl, Cynthia S Crowson, William E Krauss, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE With improving medical therapies for chronic conditions, elderly patients increasingly present as candidates for operative intervention for degenerative diseases of the spine. To date, there is a paucity of studies examining complications in lumbar decompression, without fusion, that include patients older than 80 years. Using a multicenter national database, the authors of this study evaluated lumbar decompression in the elderly, including octogenarians, to evaluate for associations between age and patient outcomes...
November 18, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27854425/a-case-review-integrating-lewin%C3%A2-s-theory-with-lean%C3%A2-s-system-approach-for-change
#11
Elizabeth Wojciechowski, Tabitha Pearsall, Patricia Murphy, Eileen French
The complexity of healthcare calls for interprofessional collaboration to improve and sustain the best outcomes for safe and high quality patient care. Historically, rehabilitation nursing has been an area that relies heavily on interprofessional relationships. Professionals from various disciplines often subscribe to different change management theories for continuous quality improvement. Through a case review, authors describe how a large, Midwestern, rehabilitation hospital used the crosswalk methodology to facilitate interprofessional collaboration and develop an intervention model for implementing and sustaining bedside shift reporting...
May 31, 2016: Online Journal of Issues in Nursing
https://www.readbyqxmd.com/read/27851067/1431-organ-failure-data-over-time-in-the-critically-ill-at-what-cost-and-to-what-benefit
#12
Andre Holder, David Murphy, Elizabeth Overton, Peter Lyu, Greg Martin, Timothy Buchman
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27846959/rethinking-screening-for-thyroid-autoimmunity-in-vitiligo
#13
EDITORIAL
Michael Liu, Elizabeth Murphy, Erin Huiras Amerson
No abstract text is available yet for this article.
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27776266/a%C3%AE-vaccination-in-combination-with-behavioral-enrichment-in-aged-beagles-effects-on-cognition-a%C3%AE-and-microhemorrhages
#14
Paulina R Davis, Ginevra Giannini, Karin Rudolph, Nathaniel Calloway, Christopher M Royer, Tina L Beckett, M Paul Murphy, Frederick Bresch, Dieter Pagani, Thomas Platt, Xiaohong Wang, Amy Skinner Donovan, Tiffany L Sudduth, Wenjie Lou, Erin Abner, Richard Kryscio, Donna M Wilcock, Edward G Barrett, Elizabeth Head
Beta-amyloid (Aβ) immunotherapy is a promising intervention to slow Alzheimer's disease. Aging dogs naturally accumulate Aβ and show cognitive decline. An active vaccine against fibrillar Aβ 1-42 (VAC) in aged beagles resulted in maintenance but not improvement of cognition along with reduced brain Aβ. Behavioral enrichment (ENR) led to cognitive benefits but no reduction in Aβ. We hypothesized cognitive outcomes could be improved by combining VAC with ENR in aged dogs. Aged dogs (11-12 years) were placed into 4 groups: (1) control/control (C/C); (2) control/VAC (C/V); (3) ENR/control (E/C); and (4) ENR/VAC (E/V) and treated for 20 months...
September 26, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27770672/population-based-analysis-of-breast-cancer-treatment-by-intrinsic-sub-type-in-manitoba-canada
#15
Elizabeth Hammond, Emma Shu, Karagin Sawchuk, Yvonne Myal, Afshin Raouf, Thomas Klonisch, Sabine Hombach-Klonisch, Etienne Leygue, Sam Kung, Janice Safneck, Michael Mowat, Wayne Xu, Leigh Murphy, Marshall Pitz
BACKGROUND: Few descriptive epidemiological studies on the incidence, treatment and survival can accurately reflect a whole population. Manitoba, Canada has an accurate cancer registry, a drug information program network and a breast screening program since 1995. This combined with a stable population provides true population data that can accurately describe the region. METHODS: Using a retrospective cohort design all Breast Cancer cases were obtained from 2004-2010 (N=5399) and grouped by Intrinsic sub-type...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27745989/imaging-findings-in-elder-abuse-a-role-for-radiologists-in-detection
#16
Natalie Z Wong, Tony Rosen, Allen M Sanchez, Elizabeth M Bloemen, Kevin W Mennitt, Keith Hentel, Refky Nicola, Kieran Murphy, Veronica M LoFaso, Neal E Flomenbaum, Mark S Lachs
PURPOSE: Emergency department assessment represents a critical but often missed opportunity to identify elder abuse, which is common and has serious consequences. Among emergency care providers, diagnostic radiologists are optimally positioned to raise suspicion for mistreatment when reviewing imaging of geriatric injury victims. However, little literature exists describing relevant injury patterns, and most radiologists currently receive neither formal nor informal training in elder abuse identification...
October 13, 2016: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/27742540/association-between-radiation-necrosis-and-tumor-biology-after-stereotactic-radiosurgery-for-brain-metastasis
#17
Jacob A Miller, Elizabeth E Bennett, Roy Xiao, Rupesh Kotecha, Samuel T Chao, Michael A Vogelbaum, Gene H Barnett, Lilyana Angelov, Erin S Murphy, Jennifer S Yu, Manmeet S Ahluwalia, John H Suh, Alireza M Mohammadi
BACKGROUND: The primary dose-limiting toxicity of stereotactic radiosurgery (SRS) is radiation necrosis (RN), which occurs after approximately 5% to 10% of treatments. This adverse event may worsen neurologic deficits, increase the frequency and cost of imaging, and necessitate prolonged treatment with steroids or antiangiogenic agents. Previous investigations have primarily identified lesion size and dosimetric constraints as risk factors for RN in small populations. We hypothesized that disease histology, receptor status, and mutational status are associated with RN...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27732066/radiologists-training-experience-and-attitudes-about-elder-abuse-detection
#18
Tony Rosen, Elizabeth M Bloemen, Jasmin Harpe, Allen M Sanchez, Kevin W Mennitt, Thomas J McCarthy, Refky Nicola, Kieran Murphy, Veronica M LoFaso, Neal Flomenbaum, Mark S Lachs
OBJECTIVE: Elder abuse is underrecognized, and identification of subtle cases requires a high index of suspicion among all health care providers. Because many geriatric injury victims undergo radiographic imaging, diagnostic radiologists may be well positioned to identify injury patterns suggestive of abuse. Little is known about radiologists' experience with elder abuse. Our goal was to describe knowledge, attitudes, training, and practice experience in elder abuse detection among diagnostic radiologists...
December 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27714532/determining-best-methods-to-screen-for-religious-spiritual-distress
#19
Stephen D W King, George Fitchett, Patricia E Murphy, Kenneth I Pargament, David A Harrison, Elizabeth Trice Loggers
PURPOSE: This study sought to validate for the first time a brief screening measure for religious/spiritual (R/S) distress given the Commission on Cancer's mandated screening for psychosocial distress including spiritual distress. METHODS: Data were collected in conjunction with an annual survey of adult hematopoietic cell transplantation (HCT) survivors. Six R/S distress screeners were compared to the Brief RCOPE, Negative Religious Coping subscale as the reference standard...
October 6, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27698281/why-do-transient-ischemic-attack-patients-have-higher-early-stroke-recurrence-risk-than-those-with-ischemic-stroke-influence-of-patient-behavior-and-other-risk-factors-in-the-north-dublin-population-stroke-study
#20
Layan Akijian, Danielle Ní Chróinín, Elizabeth Callaly, Niamh Hannon, Michael Marnane, Áine Merwick, Órla Sheehan, Derek Hayden, Gillian Horgan, Joseph Duggan, Lorraine Kyne, Killian O'Rourke, Sean Murphy, Eamon Dolan, David Williams, Peter J Kelly
BACKGROUND: Few studies have directly compared stroke recurrence rates after stroke and transient ischemic attack, and the risk factors underlying early recurrence are poorly understood. We aimed to investigate risk factors for recurrent stroke after first stroke and transient ischemic attack in a population-based study. METHODS: The North Dublin Population Stroke Study applied multiple overlapping hot and cold pursuit methods, to ascertain hospital- and community-treated stroke and transient ischemic attack patients over a 12-month period...
October 3, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
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