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https://www.readbyqxmd.com/read/28104654/draft-genome-sequence-of-the-acidophilic-halotolerant-and-iron-sulfur-oxidizing-acidihalobacter-prosperus-dsm-14174-strain-v6
#1
Himel Nahreen Khaleque, Joshua P Ramsay, Riley J T Murphy, Anna H Kaksonen, Naomi J Boxall, Elizabeth L J Watkin
The principal genomic features of Acidihalobacter prosperus DSM 14174 (strain V6) are presented here. This is a mesophilic, halotolerant, and iron/sulfur-oxidizing acidophile that was isolated from seawater at Vulcano, Italy. It has potential for use in biomining applications in regions where high salinity exists in the source water and ores.
January 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28103838/race-and-bmi-modify-associations-of-calcium-and-vitamin-d-intake-with-prostate-cancer
#2
Ken Batai, Adam B Murphy, Maria Ruden, Jennifer Newsome, Ebony Shah, Michael A Dixon, Elizabeth T Jacobs, Courtney M P Hollowell, Chiledum Ahaghotu, Rick A Kittles
BACKGROUND: African Americans have disproportionately higher burden of prostate cancer compared to European Americans. However, the cause of prostate cancer disparities is still unclear. Several roles have been proposed for calcium and vitamin D in prostate cancer pathogenesis and progression, but epidemiologic studies have been conducted mainly in European descent populations. Here we investigated the association of calcium and vitamin D intake with prostate cancer in multiethnic samples...
January 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28077418/a-novel-humanized-mouse-model-with-significant-improvement-of-class-switched-antigen-specific-antibody-production
#3
Hua Yu, Chiara Borsotti, Jean-Nicolas Schickel, Shu Zhu, Till Strowig, Elizabeth E Eynon, Davor Frleta, Cagan Gurer, Andrew J Murphy, George D Yancopoulos, Eric Meffre, Markus G Manz, Richard A Flavell
Humanized mice are a powerful tool for the study of human hematopoiesis and immune function in vivo. However, the existing models cannot support robust adaptive immune responses, especially the generation of class-switched, antigen-specific antibody responses. Here we describe a new mouse strain, in which human IL6 gene encoding the cytokine that is important for B and T cell differentiation was knocked into its respective mouse locus. The provision of human IL6 not only enhanced thymopoiesis and periphery T-cell engraftment, but also significantly increased class switched memory B cells and serum IgG...
January 11, 2017: Blood
https://www.readbyqxmd.com/read/28033512/the-beliefs-about-paranoia-scale-confirmatory-factor-analysis-and-tests-of-a-metacognitive-model-of-paranoia-in-a-clinical-sample
#4
Elizabeth K Murphy, Sarah Tully, Melissa Pyle, Andrew I Gumley, David Kingdon, Matthias Schwannauer, Douglas Turkington, Anthony P Morrison
This study aimed to confirm the factor structure of the Beliefs about Paranoia Scale (BaPS), a self-report measure to assess metacognitive beliefs about paranoia, and to test hypotheses of a metacognitive model. We hypothesised that positive and negative beliefs about paranoia would be associated with severity of suspiciousness, and that the co-occurrence of positive and negative beliefs would be associated with increased suspiciousness. A total of 335 patients meeting criteria for a schizophrenia spectrum disorder completed the BaPS, the Positive and Negative Syndromes Scale (PANSS), and the Psychotic Symptom Rating Scales (PSYRATS)...
November 12, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28007144/proteomics-research-in-cardiovascular-medicine-and-biomarker-discovery
#5
REVIEW
Maggie P Y Lam, Peipei Ping, Elizabeth Murphy
Proteomics is a systems physiology discipline to address the large-scale characterization of protein species within a biological system, be it a cell, a tissue, a body biofluid, an organism, or a cohort population. Building on advances from chemical analytical platforms (e.g., mass spectrometry and other technologies), proteomics approaches have contributed powerful applications in cardiovascular biomedicine, most notably in: 1) the discovery of circulating protein biomarkers of heart diseases from plasma samples; and 2) the identification of disease mechanisms and potential therapeutic targets in cardiovascular tissues, in both preclinical models and translational studies...
December 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28002289/in-reply
#6
Elizabeth Evans, Miles Murphy, Ethan Balk
No abstract text is available yet for this article.
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27989409/the-burden-of-ionizing-radiation-studies-in-children-with-ventricular-shunts
#7
Maria C Antonucci, Noel S Zuckerbraun, Elizabeth C Tyler-Kabara, Andre D Furtado, Meghan E Murphy, Jennifer R Marin
OBJECTIVES: To quantify the number of shunt-related imaging studies that patients with ventricular shunts undergo and to calculate the proportion of computed tomography (CT) scans associated with a surgical intervention. STUDY DESIGN: Retrospective longitudinal cohort analysis of patients up to age 22 years with a shunt placed January 2002 through December 2003 at a pediatric hospital. Primary outcome was the number of head CT scans, shunt series radiograph, skull radiographs, nuclear medicine, and brain magnetic resonance imaging studies for 10 years following shunt placement...
December 15, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27930283/mortality-in-the-united-states-2015
#8
Jiaquan Xu, Sherry L Murphy, Kenneth D Kochanek, Elizabeth Arias
Data from the National Vital Statistics System, Mortality •Life expectancy for the U.S. population in 2015 was 78.8 years, a decrease of 0.1 year from 2014. •The age-adjusted death rate increased 1.2% from 724.6 deaths per 100,000 standard population in 2014 to 733.1 in 2015. •The 10 leading causes of death in 2015 remained the same as in 2014. Age-adjusted death rates increased for eight leading causes and decreased for one. •The infant mortality rate of 589.5 infant deaths per 100,000 live births in 2015 was not significantly different from the 2014 rate...
December 2016: NCHS Data Brief
https://www.readbyqxmd.com/read/27928187/impact-of-a-training-program-on-pharmacists-comfort-with-pediatric-pharmacy-concepts-and-basic-pediatric-knowledge
#9
Elizabeth A Riney, Andrew J Crannage, Nausheen Hasan, Julie A Murphy
Objective: To determine the impact of a training program on pharmacists' comfort with pediatric pharmacy concepts and basic pediatric knowledge. Methods: All pharmacists at our institution were invited to participate in the study. Consenting participants completed a baseline survey of 15 questions on basic knowledge in 5 pediatric topic areas (pharmacokinetics/pharmacodynamics, weight-based dosing, anticoagulation, renal dosing, and common antibiotics) as well as 8 statements rating self-reported comfort with pediatric pharmacy...
November 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27911489/palliative-care-interventions-in-advanced-dementia
#10
REVIEW
Edel Murphy, Katherine Froggatt, Sheelah Connolly, Eamon O'Shea, Elizabeth L Sampson, Dympna Casey, Declan Devane
BACKGROUND: Dementia is a chronic, progressive and ultimately fatal neurodegenerative disease. Advanced dementia is characterised by profound cognitive impairment, inability to communicate verbally and complete functional dependence. Usual care of people with advanced dementia is not underpinned universally by a palliative approach. Palliative care has focused traditionally on care of people with cancer but for more than a decade, there have been increased calls worldwide to extend palliative care services to include all people with life-limiting illnesses in need of specialist care, including people with dementia...
2, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27908787/fractionating-the-anterior-temporal-lobe-mvpa-reveals-differential-responses-to-input-and-conceptual-modality
#11
Charlotte Murphy, Shirley-Ann Rueschemeyer, David Watson, Theodoros Karapanagiotidis, Jonathan Smallwood, Elizabeth Jefferies
Words activate cortical regions in accordance with their modality of presentation (i.e., written vs. spoken), yet there is a long-standing debate about whether patterns of activity in any specific brain region capture modality-invariant conceptual information. Deficits in patients with semantic dementia highlight the anterior temporal lobe (ATL) as an amodal store of semantic knowledge but these studies do not permit precise localisation of this function. The current investigation used multiple imaging methods in healthy participants to examine functional dissociations within ATL...
November 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27908218/risk-factors-for-dural-tears-a-study-of-elective-spine-surgery
#12
MULTICENTER STUDY
Meghan E Murphy, Panagiotis Kerezoudis, Mohammed Ali Alvi, Brandon A McCutcheon, Patrick R Maloney, Lorenzo Rinaldo, Daniel Shepherd, Daniel S Ubl, William E Krauss, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE: This study moves beyond previous cohort studies and benchmark data by studying a population of elective spine surgery from a multicenter registry in an effort to validate, disprove, and/or identify novel risk factors for dural tears. METHODS: A retrospective cohort analysis queried a multicenter registry for patients with degenerative spinal diagnoses undergoing elective spinal surgery from 2010-2014. Multivariable logistic regression analysis interrogated for independent risk factors of dural tears...
February 2017: Neurological Research
https://www.readbyqxmd.com/read/27901460/anesthesia-case-of-the-month
#13
Elizabeth M Goudie-DeAngelis, Erin L Wendt-Hornickle, Daniel C Almeida, Lindsey A Murphy, Lynelle F Graham
No abstract text is available yet for this article.
December 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27899525/reactive-oxygen-species-induce-virus-independent-mavs-oligomerization-in-systemic-lupus-erythematosus
#14
Iwona A Buskiewicz, Theresa Montgomery, Elizabeth C Yasewicz, Sally A Huber, Michael P Murphy, Richard C Hartley, Ryan Kelly, Mary K Crow, Andras Perl, Ralph C Budd, Andreas Koenig
The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with retinoic acid gene I (RIG-I)-like helicases during viral infection, was activated by oxidative stress independently of RIG-I helicases. We found that chemically generated oxidative stress stimulated the formation of MAVS oligomers, which led to mitochondrial hyperpolarization and decreased adenosine triphosphate production and spare respiratory capacity, responses that were not observed in similarly treated cells lacking MAVS...
November 29, 2016: Science Signaling
https://www.readbyqxmd.com/read/27869097/the-impact-of-radiation-treatment-time-on-survival-in-patients-with-head-and-neck-cancer
#15
Talha Shaikh, Elizabeth A Handorf, Colin T Murphy, Ranee Mehra, John A Ridge, Thomas J Galloway
PURPOSE: To assess the impact of radiation treatment time (RTT) in head and neck cancers on overall survival (OS) in the era of chemoradiation. METHODS AND MATERIALS: Patients with diagnoses of tongue, hypopharynx, larynx, oropharynx, or tonsil cancer were identified by use of the National Cancer Database. RTT was defined as date of first radiation treatment to date of last radiation treatment. In the definitive setting, prolonged RTT was defined as >56 days, accelerated RTT was defined as <47 days, and standard RTT was defined as 47 to 56 days...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27866034/micro-vs-macrodiscectomy-does-use-of-the-microscope-reduce-complication-rates
#16
Meghan E Murphy, Jeffrey S Hakim, Panagiotis Kerezoudis, Mohammed Ali Alvi, Daniel S Ubl, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE: A single level discectomy is one of the most common procedures performed by spine surgeons. While some practitioners utilize the microscope, others do not. We postulate improved visualization with an intraoperative microscope decreases complications and inferior outcomes. METHODS: A multicenter surgical registry was utilized for this retrospective cohort analysis. Patients with degenerative spinal diagnoses undergoing elective single level discectomies from 2010 to 2014 were included...
January 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27858534/lumbar-decompression-in-the-elderly-increased-age-as-a-risk-factor-for-complications-and-nonhome-discharge
#17
Meghan E Murphy, Hannah Gilder, Patrick R Maloney, Brandon A McCutcheon, Lorenzo Rinaldo, Daniel Shepherd, Panagiotis Kerezoudis, Daniel S Ubl, Cynthia S Crowson, William E Krauss, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE With improving medical therapies for chronic conditions, elderly patients increasingly present as candidates for operative intervention for degenerative diseases of the spine. To date, there is a paucity of studies examining complications in lumbar decompression, without fusion, that include patients older than 80 years. Using a multicenter national database, the authors of this study evaluated lumbar decompression in the elderly, including octogenarians, to evaluate for associations between age and patient outcomes...
November 18, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27854425/a-case-review-integrating-lewin%C3%A2-s-theory-with-lean%C3%A2-s-system-approach-for-change
#18
Elizabeth Wojciechowski, Tabitha Pearsall, Patricia Murphy, Eileen French
The complexity of healthcare calls for interprofessional collaboration to improve and sustain the best outcomes for safe and high quality patient care. Historically, rehabilitation nursing has been an area that relies heavily on interprofessional relationships. Professionals from various disciplines often subscribe to different change management theories for continuous quality improvement. Through a case review, authors describe how a large, Midwestern, rehabilitation hospital used the crosswalk methodology to facilitate interprofessional collaboration and develop an intervention model for implementing and sustaining bedside shift reporting...
May 31, 2016: Online Journal of Issues in Nursing
https://www.readbyqxmd.com/read/27851067/1431-organ-failure-data-over-time-in-the-critically-ill-at-what-cost-and-to-what-benefit
#19
Andre Holder, David Murphy, Elizabeth Overton, Peter Lyu, Greg Martin, Timothy Buchman
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27846959/rethinking-screening-for-thyroid-autoimmunity-in-vitiligo
#20
EDITORIAL
Michael Liu, Elizabeth Murphy, Erin Huiras Amerson
No abstract text is available yet for this article.
December 2016: Journal of the American Academy of Dermatology
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