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https://www.readbyqxmd.com/read/28425908/rotavirus-vaccine-breastfeeding-and-other-factors-that-could-affect-susceptibility-to-gastroenteritis-in-young-children
#1
Amy Elizabeth Murphy
No abstract available.
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28423313/power-grid-protection-of-the-muscle-mitochondrial-reticulum
#2
Brian Glancy, Lisa M Hartnell, Christian A Combs, Armel Fenmou, Junhui Sun, Elizabeth Murphy, Sriram Subramaniam, Robert S Balaban
Mitochondrial network connectivity enables rapid communication and distribution of potential energy throughout the cell. However, this connectivity puts the energy conversion system at risk, because damaged elements could jeopardize the entire network. Here, we demonstrate the mechanisms for mitochondrial network protection in heart and skeletal muscle (SKM). We find that the cardiac mitochondrial reticulum is segmented into subnetworks comprising many mitochondria linked through abundant contact sites at highly specific intermitochondrial junctions (IMJs)...
April 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28420032/identifying-a-subset-of-patients-with-dcis-who-have-a-low-likelihood-of-residual-disease-at-surgical-excision-following-a-core-needle-biopsy
#3
Brittany L Murphy, Alexandra B Gonzalez, Amy L Conners, Tara L Henrichsen, Michael G Keeney, Beiyun Chen, Toan T Nguyen, William S Harmsen, Elizabeth B Habermann, Harsh N Shah, James W Jakub
BACKGROUND AND OBJECTIVES: Current randomized controlled trials are investigating the outcomes of non-surgical treatment for patients with ductal carcinoma in situ (DCIS). We sought to evaluate pre-operative factors associated with no residual disease at definitive resection following a core needle biopsy (CNB) diagnosis of DCIS. METHODS: Eight hundred and thirty-four operations for DCIS were performed at our institution between January 2004 and October 2014. We evaluated patient and biopsy tumor characteristics to determine pre-operative factors associated with no residual disease at surgical resection using uni- and multivariable analyses...
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28419748/the-known-genetic-potential-for-microbial-communities-to-degrade-organic-phosphorus-is-reduced-in-low-ph-soils
#4
Ian D E A Lidbury, Tandra Fraser, Andrew R J Murphy, David J Scanlan, Gary D Bending, Alexandra M E Jones, Jonathan D Moore, Andrew Goodall, Mark Tibbett, John P Hammond, Elizabeth M H Wellington
In soil, bioavailable inorganic orthophosphate is found at low concentrations and thus limits biological growth. To overcome this phosphorus scarcity, plants and bacteria secrete numerous enzymes, namely acid and alkaline phosphatases, which cleave orthophosphate from various organic phosphorus substrates. Using profile hidden Markov modeling approaches, we investigated the abundance of various non specific phosphatases, both acid and alkaline, in metagenomes retrieved from soils with contrasting pH regimes...
April 16, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28404094/development-and-validation-of-a-dynamic-outcome-prediction-model-for-paracetamol-induced-acute-liver-failure-a-cohort-study
#5
William Bernal, Yanzhong Wang, James Maggs, Christopher Willars, Elizabeth Sizer, Georg Auzinger, Nicholas Murphy, Damian Harding, Ahmed Elsharkawy, Kenneth Simpson, Fin Stolze Larsen, Nigel Heaton, John O'Grady, Roger Williams, Julia Wendon
BACKGROUND: Early, accurate prediction of survival is central to management of patients with paracetamol-induced acute liver failure to identify those needing emergency liver transplantation. Current prognostic tools are confounded by recent improvements in outcome independent of emergency liver transplantation, and constrained by static binary outcome prediction. We aimed to develop a simple prognostic tool to reflect current outcomes and generate a dynamic updated estimation of risk of death...
November 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28385551/down-syndrome-age-dependence-of-pib-binding-in-postmortem-frontal-cortex-across-the-lifespan
#6
Harry LeVine, H Peter Spielmann, Sergey Matveev, Francesca Macchiavello Cauvi, M Paul Murphy, Tina L Beckett, Katie McCarty, Ira T Lott, Eric Doran, Frederick Schmitt, Elizabeth Head
Beta-amyloid (Aβ) deposition in brain accumulates as a function of age in people with Down syndrome (DS) with subsequent development into Alzheimer disease neuropathology, typically by 40 years of age. In vivo imaging using the Pittsburgh compound B (PiB) ligand has facilitated studies linking Aβ, cognition, and dementia in DS. However, there are no studies of PiB binding across the lifespan in DS. The current study describes in vitro (3)H-PiB binding in the frontal cortex of autopsy cases with DS compared to non-DS controls...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28368183/evaluation-of-a-cognitive-remediation-intervention-for-college-students-with-psychiatric-conditions
#7
Michelle G Mullen, Judy L Thompson, Ann A Murphy, Derek Malenczak, Giovanna Giacobbe, Sean Karyczak, Katherine E Holloway, Elizabeth W Twamley, Steven M Silverstein, Kenneth J Gill
OBJECTIVE: Given the poor educational outcomes associated with psychiatric conditions, we developed Focused Academic Strength Training (FAST), a 12-week strategy-focused cognitive remediation intervention designed to improve academic functioning among college students with psychiatric conditions. Here we report initial results from a randomized controlled trial of FAST. METHOD: Seventy-two college students with mood, anxiety, and/or psychotic disorders were randomized to receive FAST or services as usual and were assessed at baseline and 4 months (posttreatment)...
March 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28366801/click-pegylation-a-mobility-shift-approach-to-assess-the-redox-state-of-cysteines-in-candidate-proteins
#8
Lucie A G van Leeuwen, Elizabeth C Hinchy, Michael P Murphy, Ellen L Robb, Helena M Cochemé
The redox state of cysteine thiols is critical for protein function. Whereas cysteines play an important role in the maintenance of protein structure through the formation of internal disulfides, their nucleophilic thiol groups can become oxidatively modified in response to diverse redox challenges and thereby function in signalling and antioxidant defences. These oxidative modifications occur in response to a range of agents and stimuli, and can lead to the existence of multiple redox states for a given protein...
March 31, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28352658/priming-is-key-to-effective-incorporation-of-image-guided-thermal-ablation-into-immunotherapy-protocols
#9
Matthew T Silvestrini, Elizabeth S Ingham, Lisa M Mahakian, Azadeh Kheirolomoom, Yu Liu, Brett Z Fite, Sarah M Tam, Samantha T Tucci, Katherine D Watson, Andrew W Wong, Arta M Monjazeb, Neil E Hubbard, William J Murphy, Alexander D Borowsky, Katherine W Ferrara
Focal therapies play an important role in the treatment of cancers where palliation is desired, local control is needed, or surgical resection is not feasible. Pairing immunotherapy with such focal treatments is particularly attractive; however, there is emerging evidence that focal therapy can have a positive or negative impact on the efficacy of immunotherapy. Thermal ablation is an appealing modality to pair with such protocols, as tumors can be rapidly debulked (cell death occurring within minutes to hours), tumor antigens can be released locally, and treatment can be conducted and repeated without the concerns of radiation-based therapies...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28286030/impact-of-an-electronic-handoff-documentation-tool-on-team-shared-mental-models-in-pediatric-critical-care
#10
Silis Y Jiang, Alexandrea Murphy, Elizabeth M Heitkemper, R Stanley Hum, David R Kaufman, Lena Mamykina
OBJECTIVE: To examine the impact of the implementation of an electronic handoff tool (the Handoff Tool) on shared mental models (SMM) within patient care teams as measured by content overlap and discrepancies in verbal handoff presentations given by different clinicians caring for the same patient. MATERIALS AND METHODS: Researchers observed, recorded, and transcribed verbal handoffs given by different members of patient care teams in a pediatric intensive care unit...
March 7, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28242696/structural-basis-of-autoregulatory-scaffolding-by-apoptosis-signal-regulating-kinase-1
#11
Johannes F Weijman, Abhishek Kumar, Sam A Jamieson, Chontelle M King, Tom T Caradoc-Davies, Elizabeth C Ledgerwood, James M Murphy, Peter D Mace
Apoptosis signal-regulating kinases (ASK1-3) are apical kinases of the p38 and JNK MAP kinase pathways. They are activated by diverse stress stimuli, including reactive oxygen species, cytokines, and osmotic stress; however, a molecular understanding of how ASK proteins are controlled remains obscure. Here, we report a biochemical analysis of the ASK1 kinase domain in conjunction with its N-terminal thioredoxin-binding domain, along with a central regulatory region that links the two. We show that in solution the central regulatory region mediates a compact arrangement of the kinase and thioredoxin-binding domains and the central regulatory region actively primes MKK6, a key ASK1 substrate, for phosphorylation...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28239943/unprecedented-complication-of-biologic-mesh-use-in-ventral-rectopexy
#12
Sean Leow, Frank Voyvodic, Elizabeth Murphy, Dayan de Fontgalland
No abstract text is available yet for this article.
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28203832/metabolic-cardiomyopathies-fighting-the-next-epidemic
#13
Christoph Maack, Elizabeth Murphy
No abstract text is available yet for this article.
February 16, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28197420/the-challenges-of-electronic-health-records-and-diabetes-electronic-prescribing-implications-for-safety-net-care-for-diverse-populations
#14
REVIEW
Neda Ratanawongsa, Lenny L S Chan, Michelle M Fouts, Elizabeth J Murphy
Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformation has affected diabetes care for vulnerable patients and offers recommendations for improving patient safety through EHR electronic prescribing design, implementation, policy, and research. Specifically, we present evidence for (1) the adoption of RxNorm; (2) standardized naming and picklist options for high alert medications such as insulin; (3) the widespread implementation of universal medication schedule and language-concordant labels, with the expansion of electronic prescription 140-character limit; (4) enhanced bidirectional communication with pharmacy partners; and (5) informatics and implementation research in safety net healthcare systems to examine how EHR tools and practices affect diverse vulnerable populations...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28196901/novel-variant-in-the-ank2-membrane-binding-domain-is-associated-with-ankyrin-b-syndrome-and-structural-heart-disease-in-a-first-nations-population-with-a-high-rate-of-long-qt-syndrome
#15
Leigh Anne Swayne, Nathaniel P Murphy, Sirisha Asuri, Lena Chen, Xiaoxue Xu, Sarah McIntosh, Chao Wang, Peter J Lancione, Jason D Roberts, Charles Kerr, Shubhayan Sanatani, Elizabeth Sherwin, Crystal F Kline, Mingjie Zhang, Peter J Mohler, Laura T Arbour
BACKGROUND: Long QT syndrome confers susceptibility to ventricular arrhythmia, predisposing to syncope, seizures, and sudden death. While rare globally, long QT syndrome is ≈15× more common in First Nations of Northern British Columbia largely because of a known mutation in KCNQ1. However, 2 large multigenerational families were affected, but negative for the known mutation. METHODS AND RESULTS: Long QT syndrome panel testing was carried out in the index case of each family, and clinical information was collected...
January 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28191895/erratum-espl-is-a-bacterial-cysteine-protease-effector-that-cleaves-rhim-proteins-to-block-necroptosis-and-inflammation
#16
Jaclyn S Pearson, Cristina Giogha, Sabrina Mühlen, Ueli Nachbur, Chi L L Pham, Ying Zhang, Joanne M Hildebrand, Clare V Oates, Tania Wong Fok Lung, Danielle Ingle, Laura F Dagley, Aleksandra Bankovacki, Emma J Petrie, Gunnar N Schroeder, Valerie F Crepin, Gad Frankel, Seth L Masters, James Vince, James M Murphy, Margaret Sunde, Andrew I Webb, John Silke, Elizabeth L Hartland
No abstract text is available yet for this article.
February 13, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28191447/reexamining-chronic-toxoplasma-gondii-infection-surprising-activity-for-a-dormant-parasite
#17
Anthony P Sinai, Elizabeth A Watts, Animesh Dhara, Robert D Murphy, Matthew S Gentry, Abhijit Patwardhan
PURPOSE OF REVIEW: Despite over a third of the world's population being chronically infected with Toxoplasma gondii, little is known about this largely asymptomatic phase of infection. This stage is mediated in vivo by bradyzoites within tissue cysts. The absence of overt symptoms has been attributed to the dormancy of bradyzoites. In this review, we reexamine the conventional view of chronic toxoplasmosis in light of emerging evidence challenging both the nature of dormancy and the consequences of infection in the CNS...
December 2016: Current Clinical Microbiology Reports
https://www.readbyqxmd.com/read/28175523/331%C3%A2-association-between-radiation-necrosis-and-tumor-biology-following-stereotactic-radiosurgery-for-brain-metastasis
#18
Jacob A Miller, Elizabeth Emily Bennett, Roy Xiao, Rupesh Kotecha, Samuel T Chao, Michael A Vogelbaum, Gene H Barnett, Lilyana Angelov, Erin Murphy, Jennifer Yu, Manmeet Ahluwalia, John H Suh, Alireza M Mohammadi
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28158412/sex-differences-in-metabolic-cardiomyopathy
#19
Elizabeth Murphy, Georgios Amanakis, Natasha Fillmore, Randi J Parks, Junhui Sun
No abstract text is available yet for this article.
February 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28151003/engaging-diverse-stakeholders-to-inform-biobank-governance
#20
Marie Murphy, Sarah B Garrett, Elizabeth Boyd, Sarah Dry, Daniel Dohan
No abstract text is available yet for this article.
February 2, 2017: Biopreservation and Biobanking
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