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https://www.readbyqxmd.com/read/28941898/interlaboratory-validation-of-an-improved-method-for-detection-of-cyclospora-cayetanensis-in-produce-using-a-real-time-pcr-assay
#1
Helen R Murphy, Hediye Nese Cinar, Gopal Gopinath, Kathy E Noe, Lacresha D Chatman, Nancy E Miranda, June H Wetherington, Jason Neal-McKinney, Gabrielle S Pires, Elizabeth Sachs, Kristopher J Stanya, Cynthia L Johnson, Fernanda S Nascimento, Monica Santin, Aleksey Molokin, Mansour Samadpour, Harish Janagama, Amy Kahler, Candace Miller, Alexandre J da Silva
A collaborative validation study was performed to evaluate the performance of a new U.S. Food and Drug Administration method developed for detection of the protozoan parasite, Cyclospora cayetanensis, on cilantro and raspberries. The method includes a sample preparation step in which oocysts are recovered from produce using an enhanced produce washing solution containing 0.1% Alconox and a commercially available method to disrupt the C. cayetanensis oocysts and extract DNA. A real-time PCR assay targeting the C...
February 2018: Food Microbiology
https://www.readbyqxmd.com/read/28937324/impact-of-2-staged-stereotactic-radiosurgery-for-treatment-of-brain-metastases-%C3%A2-2-cm
#2
Lilyana Angelov, Alireza M Mohammadi, Elizabeth E Bennett, Mahmoud Abbassy, Paul Elson, Samuel T Chao, Joshua S Montgomery, Ghaith Habboub, Michael A Vogelbaum, John H Suh, Erin S Murphy, Manmeet S Ahluwalia, Sean J Nagel, Gene H Barnett
OBJECTIVE Stereotactic radiosurgery (SRS) is the primary modality for treating brain metastases. However, effective radiosurgical control of brain metastases ≥ 2 cm in maximum diameter remains challenging and is associated with suboptimal local control (LC) rates of 37%-62% and an increased risk of treatment-related toxicity. To enhance LC while limiting adverse effects (AEs) of radiation in these patients, a dose-dense treatment regimen using 2-staged SRS (2-SSRS) was used. The objective of this study was to evaluate the efficacy and toxicity of this treatment strategy...
September 22, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28923698/trends-of-inguinal-hernia-repairs-performed-for-recurrence-in-the-united-states
#3
Brittany L Murphy, Daniel S Ubl, Jianying Zhang, Elizabeth B Habermann, David R Farley, Keith Paley
BACKGROUND: One of the main complications of inguinal hernia repair continues to be recurrence. Commonly cited prior reports from relatively small studies estimate this rate to be 1% to 5% in the United States. Although some reports have found higher recurrence rates, they get little attention on the national stage or in other large studies. We sought to determine the trend of inguinal hernia repairs performed for recurrence over time using large national databases. METHODS: We identified patients aged ≥18 years who underwent inguinal hernia repair from three sources: the Premier database (January 2010 to September 2015), the American College of Surgeons National Surgical Quality Improvement Program database (January 2005 to December 2014), and the Mayo Clinic institutions (January 2005 to December 2014)...
September 15, 2017: Surgery
https://www.readbyqxmd.com/read/28906286/serial-daily-organ-failure-assessment-beyond-icu-day-5-does-not-independently-add-precision-to-icu-risk-of-death-prediction
#4
Andre L Holder, Elizabeth Overton, Peter Lyu, Jordan A Kempker, Shamim Nemati, Fereshteh Razmi, Greg S Martin, Timothy G Buchman, David J Murphy
OBJECTIVES: To identify circumstances in which repeated measures of organ failure would improve mortality prediction in ICU patients. DESIGN: Retrospective cohort study, with external validation in a deidentified ICU database. SETTING: Eleven ICUs in three university hospitals within an academic healthcare system in 2014. PATIENTS: Adults (18 yr old or older) who satisfied the following criteria: 1) two of four systemic inflammatory response syndrome criteria plus an ordered blood culture, all within 24 hours of hospital admission; and 2) ICU admission for at least 2 calendar days, within 72 hours of emergency department presentation...
September 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28888992/associations-between-biological-markers-of-prenatal-stress-and-infant-negative-emotionality-are-specific-to-sex
#5
Elizabeth C Braithwaite, Susannah E Murphy, Paul G Ramchandani, Jonathan Hill
PURPOSE: Fetal programming is the idea that environmental stimuli can alter the development of the fetus, which may have a long-term effect on the child. We have recently reported that maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner: high prenatal cortisol was associated with increased negative emotionality in females, and decreased negative emotionality in males. This study aims to test for this sex-specific effect in a different cohort, and investigate whether sex differences in fetal programming may be specific to glucocorticoid mechanisms by also examining a maternal salivary alpha-amylase (sAA) by sex interaction...
September 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28866247/using-personal-construct-methodology-to-explore-relationships-with-adolescents-with-autism-spectrum-disorder
#6
Mark Murphy, Jan Burns, Elizabeth Kilbey
BACKGROUND: Research shows that adolescents with Autism Spectrum Disorder (ASD) experience difficulties developing friendships, and that loneliness is a significant factor contributing to higher incidence of anxiety and depression within this population. AIMS: This study aimed to provide an in-depth analysis of relationships as described by adolescents with ASD, and, from these descriptions, to explore what can be inferred about the development of successful interpersonal relationships for these individuals...
August 31, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28862954/a-systems-biology-approach-to-investigating-sex-differences-in-cardiac-hypertrophy
#7
Josephine Harrington, Natasha Fillmore, Shouguo Gao, Yanqin Yang, Xue Zhang, Poching Liu, Andrea Stoehr, Ye Chen, Danielle Springer, Jun Zhu, Xujing Wang, Elizabeth Murphy
BACKGROUND: Heart failure preceded by hypertrophy is a leading cause of death, and sex differences in hypertrophy are well known, although the basis for these sex differences is poorly understood. METHODS AND RESULTS: This study used a systems biology approach to investigate mechanisms underlying sex differences in cardiac hypertrophy. Male and female mice were treated for 2 and 3 weeks with angiotensin II to induce hypertrophy. Sex differences in cardiac hypertrophy were apparent after 3 weeks of treatment...
August 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28828583/incorporation-of-treatment-response-tumor-grade-and-receptor-status-improves-staging-quality-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy
#8
John R Bergquist, Brittany L Murphy, Curtis B Storlie, Elizabeth B Habermann, Judy C Boughey
BACKGROUND: Improved staging systems that better predict survival for breast cancer patients who receive neoadjuvant chemotherapy (NAC) by accounting for clinical pathological stage plus estrogen receptor (ER) and grade (CPS+EG) and ERBB2 status (Neo-Bioscore) have been proposed. We sought to evaluate the generalizability and performance of these staging systems in a national cohort. METHODS: The National Cancer Database (2006-2012) was reviewed for patients with breast cancer who received NAC and survived ≥90 days after surgery...
August 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28766201/selective-use-of-sentinel-lymph-node-surgery-in-patients-undergoing-prophylactic-mastectomy-using-intraoperative-pathology
#9
Brittany L Murphy, Amy E Glasgow, Gary L Keeney, Elizabeth B Habermann, Judy C Boughey
BACKGROUND: Routine sentinel lymph node (SLN) surgery during prophylactic mastectomy (PM) is unnecessary, because most PMs do not contain cancer. Our institution utilizes intraoperative pathology to guide the surgical decision for resection of SLNs in PM. The purpose of this study was to review the effectiveness of this approach. METHODS: We identified all women aged ≥18 years who underwent bilateral PM (BPM) or contralateral PM (CPM) at our institution from January 2008 to July 2016...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28766196/a-validated-nomogram-to-predict-upstaging-of-ductal-carcinoma-in-situ-to-invasive-disease
#10
James W Jakub, Brittany L Murphy, Alexandra B Gonzalez, Amy L Conners, Tara L Henrichsen, Santo Maimone, Michael G Keeney, Sarah A McLaughlin, Barbara A Pockaj, Beiyun Chen, Tashinga Musonza, William S Harmsen, Judy C Boughey, Tina J Hieken, Elizabeth B Habermann, Harsh N Shah, Amy C Degnim
BACKGROUND: Approximately 8-56% of patients with a core needle biopsy (CNB) diagnosis of ductal carcinoma in situ (DCIS) will be upstaged to invasive disease at the time of excision. Patients with invasive disease are recommended to undergo axillary nodal staging, most often requiring a second operation. We developed and validated a nomogram to preoperatively predict percentage of risk for upstaging to invasive cancer. METHODS: We reviewed 834 cases of DCIS on CNB between January 2004 and October 2014...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28737219/impacts-of-hydraulic-redistribution-on-grass-tree-competition-vs-facilitation-in-a-semi-arid-savanna
#11
Greg A Barron-Gafford, Enrique P Sanchez-Cañete, Rebecca L Minor, Sean M Hendryx, Esther Lee, Leland F Sutter, Newton Tran, Elizabeth Parra, Tony Colella, Patrick C Murphy, Erik P Hamerlynck, Praveen Kumar, Russell L Scott
A long-standing ambition in ecosystem science has been to understand the relationship between ecosystem community composition, structure and function. Differential water use and hydraulic redistribution have been proposed as one mechanism that might allow for the coexistence of overstory woody plants and understory grasses. Here, we investigated how patterns of hydraulic redistribution influence overstory and understory ecophysiological function and how patterns vary across timescales of an individual precipitation event to an entire growing season...
September 2017: New Phytologist
https://www.readbyqxmd.com/read/28713554/growth-hormone-receptor-antagonism-with-pegvisomant-in-insulin-resistant-non-diabetic-men-a-phase-ii-pilot-study
#12
Ada P Lee, Kathleen Mulligan, Morris Schambelan, Elizabeth J Murphy, Ethan J Weiss
Background: Growth hormone (GH) is known to affect insulin and glucose metabolism.  Blocking its effects in acromegalic patients improves diabetes and glucose metabolism. We aimed to determine the effect of pegvisomant, a GH receptor antagonist, on insulin resistance, endogenous glucose production (EGP) and lipolysis in insulin resistant non-diabetic men.  Methods: Four men between the ages of 18-62 with a BMI of 18-35kg/m (2), with insulin resistance as defined by a HOMA-IR > 2.77, were treated for four weeks with pegvisomant 20 mg daily...
2017: F1000Research
https://www.readbyqxmd.com/read/28704649/indoleacrylic-acid-produced-by-commensal-peptostreptococcus-species-suppresses-inflammation
#13
Marta Wlodarska, Chengwei Luo, Raivo Kolde, Eva d'Hennezel, John W Annand, Cortney E Heim, Philipp Krastel, Esther K Schmitt, Abdifatah S Omar, Elizabeth A Creasey, Ashley L Garner, Sina Mohammadi, Daniel J O'Connell, Sahar Abubucker, Timothy D Arthur, Eric A Franzosa, Curtis Huttenhower, Leon O Murphy, Henry J Haiser, Hera Vlamakis, Jeffrey A Porter, Ramnik J Xavier
Host factors in the intestine help select for bacteria that promote health. Certain commensals can utilize mucins as an energy source, thus promoting their colonization. However, health conditions such as inflammatory bowel disease (IBD) are associated with a reduced mucus layer, potentially leading to dysbiosis associated with this disease. We characterize the capability of commensal species to cleave and transport mucin-associated monosaccharides and identify several Clostridiales members that utilize intestinal mucins...
July 12, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28671818/an-ear-on-environmental-surveillance-and-monitoring-a-case-study-on-the-use-of-exposure-activity-ratios-ears-to-prioritize-sites-chemicals-and-bioactivities-of-concern-in-great-lakes-waters
#14
Brett R Blackwell, Gerald T Ankley, Steven R Corsi, Laura A DeCicco, Keith A Houck, Richard S Judson, Shibin Li, Matthew T Martin, Elizabeth Murphy, Anthony L Schroeder, Edwin R Smith, Joe Swintek, Daniel L Villeneuve
Current environmental monitoring approaches focus primarily on chemical occurrence. However, based on concentration alone, it can be difficult to identify which compounds may be of toxicological concern and should be prioritized for further monitoring, in-depth testing, or management. This can be problematic because toxicological characterization is lacking for many emerging contaminants. New sources of high-throughput screening (HTS) data, such as the ToxCast database, which contains information for over 9000 compounds screened through up to 1100 bioassays, are now available...
July 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28670483/best-practices-in-social-and-behavioral-research-report-from-the-enhancing-clinical-research-professional-s-training-and-qualifications-project
#15
Susan L Murphy, Christine Byks-Jazayeri, Nancy Calvin-Naylor, Vic Divecha, Elizabeth Anderson, Brenda Eakin, Alecia Fair, Laura Denton
INTRODUCTION: This article discusses the process of defining competencies and development of a best practices training course for investigators and clinical research coordinators who conduct social and behavioral research. METHODS: The first project phase established recommendations for training in Good Clinical Practice (GCP) and was done in conjunction with representatives from 62 Clinical and Translational Science Award (CTSA) hubs. Diversity in behavioral clinical trials and differences in regulation of behavioral trials compared with clinical trials involving drugs, devices, or biologics necessitated a separate Social and Behavioral Work Group...
February 2017: Journal of clinical and translational science
https://www.readbyqxmd.com/read/28662099/intratumoural-production-of-tnf%C3%AE-by-bacteria-mediates-cancer-therapy
#16
Carola Murphy, Elizabeth Rettedal, Panos Lehouritis, Ciarán Devoy, Mark Tangney
Systemic administration of the highly potent anticancer therapeutic, tumour necrosis factor alpha (TNFα) induces high levels of toxicity and is responsible for serious side effects. Consequently, tumour targeting is required in order to confine this toxicity within the locality of the tumour. Bacteria have a natural capacity to grow within tumours and deliver therapeutic molecules in a controlled fashion. The non-pathogenic E. coli strain MG1655 was investigated as a tumour targeting system in order to produce TNFα specifically within murine tumours...
2017: PloS One
https://www.readbyqxmd.com/read/28655631/varieties-of-semantic-cognition-revealed-through-simultaneous-decomposition-of-intrinsic-brain-connectivity-and-behaviour
#17
Deniz Vatansever, Danilo Bzdok, Hao-Ting Wang, Giovanna Mollo, Mladen Sormaz, Charlotte Murphy, Theodoros Karapanagiotidis, Jonathan Smallwood, Elizabeth Jefferies
Contemporary theories assume that semantic cognition emerges from a neural architecture in which different component processes are combined to produce aspects of conceptual thought and behaviour. In addition to the state-level, momentary variation in brain connectivity, individuals may also differ in their propensity to generate particular configurations of such components, and these trait-level differences may relate to individual differences in semantic cognition. We tested this view by exploring how variation in intrinsic brain functional connectivity between semantic nodes in fMRI was related to performance on a battery of semantic tasks in 154 healthy participants...
June 24, 2017: NeuroImage
https://www.readbyqxmd.com/read/28650232/pharmacokinetics-of-cyclophosphamide-and-4-hydroxycyclophosphamide-in-cats-after-oral-intravenous-and-intraperitoneal-administration-of-cyclophosphamide
#18
Katherine A Stroda, Jacqueline D Murphy, Ryan J Hansen, Lisa Brownlee, Elizabeth A Atencio, Daniel L Gustafson, Susan E Lana
OBJECTIVE To characterize pharmacokinetics of cyclophosphamide and 4-hydoxycyclophosphamide (4-OHCP) in the plasma of healthy cats after oral, IV, and IP administration of cyclophosphamide. ANIMALS 6 healthy adult cats. PROCEDURES Cats were randomly assigned to receive cyclophosphamide (200 mg/m(2)) via each of 3 routes of administration (oral, IV, and IP); there was a 30-day washout period between successive treatments. Plasma samples were obtained at various time points for up to 8 hours after administration...
July 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28644097/thirty-day-postoperative-morbidity-and-mortality-after-temporal-lobectomy-for-medically-refractory-epilepsy
#19
Panagiotis Kerezoudis, Brandon McCutcheon, Meghan E Murphy, Kenan R Rajjoub, Daniel Ubl, Elizabeth B Habermann, Gregory Worrell, Mohamad Bydon, Jamie J Van Gompel
OBJECTIVE Temporal lobectomy is a well-established treatment modality for the management of medically refractory epilepsy in appropriately selected patients. The aim of this study was to assess 30-day morbidity and mortality after temporal lobectomy in cases registered in a national database. METHODS A retrospective cohort analysis was conducted using a multiinstitutional surgical registry compiled between 2006 and 2014. The authors identified patients who underwent anterior temporal lobectomy and/or amygdalohippocampectomy for a primary diagnosis of intractable epilepsy...
June 23, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28643553/renal-dysfunction-and-chronic-kidney-disease-in-ischemic-stroke-and-transient-ischemic-attack-a-population-based-study
#20
Derek Hayden, Christine McCarthy, Layan Akijian, Elizabeth Callaly, Danielle Ní Chróinín, Gillian Horgan, Lorraine Kyne, Joseph Duggan, Eamon Dolan, Killian O' Rourke, David Williams, Sean Murphy, Yvonne O'Meara, Peter J Kelly
Background and purpose The prevalence of chronic kidney disease (estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m(2) for ≥3 months, chronic kidney disease (CKD)) in ischemic stroke and transient ischemic attack (TIA) is unknown, as estimates have been based on single-point estimates of renal function. Studies investigating the effect of renal dysfunction (eGFR < 60 mL/min per 1.73 m(2), renal dysfunction) on post-stroke outcomes are limited to hospitalized cohorts and have provided conflicting results...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
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