keyword
MENU ▼
Read by QxMD icon Read
search

elizabeth murphy

keyword
https://www.readbyqxmd.com/read/28286030/impact-of-an-electronic-handoff-documentation-tool-on-team-shared-mental-models-in-pediatric-critical-care
#1
Silis Y Jiang, Alexandrea Murphy, Elizabeth M Heitkemper, R Stanley Hum, David R Kaufman, Lena Mamykina
OBJECTIVE: To examine the impact of the implementation of an electronic handoff tool (the Handoff Tool) on shared mental models (SMM) within patient care teams as measured by content overlap and discrepancies in verbal handoff presentations given by different clinicians caring for the same patient. MATERIALS AND METHODS: Researchers observed, recorded, and transcribed verbal handoffs given by different members of patient care teams in a pediatric intensive care unit...
March 7, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28242696/structural-basis-of-autoregulatory-scaffolding-by-apoptosis-signal-regulating-kinase-1
#2
Johannes F Weijman, Abhishek Kumar, Sam A Jamieson, Chontelle M King, Tom T Caradoc-Davies, Elizabeth C Ledgerwood, James M Murphy, Peter D Mace
Apoptosis signal-regulating kinases (ASK1-3) are apical kinases of the p38 and JNK MAP kinase pathways. They are activated by diverse stress stimuli, including reactive oxygen species, cytokines, and osmotic stress; however, a molecular understanding of how ASK proteins are controlled remains obscure. Here, we report a biochemical analysis of the ASK1 kinase domain in conjunction with its N-terminal thioredoxin-binding domain, along with a central regulatory region that links the two. We show that in solution the central regulatory region mediates a compact arrangement of the kinase and thioredoxin-binding domains and the central regulatory region actively primes MKK6, a key ASK1 substrate, for phosphorylation...
February 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28239943/unprecedented-complication-of-biologic-mesh-use-in-ventral-rectopexy
#3
Sean Leow, Frank Voyvodic, Elizabeth Murphy, Dayan de Fontgalland
No abstract text is available yet for this article.
February 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28203832/metabolic-cardiomyopathies-fighting-the-next-epidemic
#4
Christoph Maack, Elizabeth Murphy
No abstract text is available yet for this article.
February 16, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28197420/the-challenges-of-electronic-health-records-and-diabetes-electronic-prescribing-implications-for-safety-net-care-for-diverse-populations
#5
REVIEW
Neda Ratanawongsa, Lenny L S Chan, Michelle M Fouts, Elizabeth J Murphy
Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformation has affected diabetes care for vulnerable patients and offers recommendations for improving patient safety through EHR electronic prescribing design, implementation, policy, and research. Specifically, we present evidence for (1) the adoption of RxNorm; (2) standardized naming and picklist options for high alert medications such as insulin; (3) the widespread implementation of universal medication schedule and language-concordant labels, with the expansion of electronic prescription 140-character limit; (4) enhanced bidirectional communication with pharmacy partners; and (5) informatics and implementation research in safety net healthcare systems to examine how EHR tools and practices affect diverse vulnerable populations...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28196901/novel-variant-in-the-ank2-membrane-binding-domain-is-associated-with-ankyrin-b-syndrome-and-structural-heart-disease-in-a-first-nations-population-with-a-high-rate-of-long-qt-syndrome
#6
Leigh Anne Swayne, Nathaniel P Murphy, Sirisha Asuri, Lena Chen, Xiaoxue Xu, Sarah McIntosh, Chao Wang, Peter J Lancione, Jason D Roberts, Charles Kerr, Shubhayan Sanatani, Elizabeth Sherwin, Crystal F Kline, Mingjie Zhang, Peter J Mohler, Laura T Arbour
BACKGROUND: Long QT syndrome confers susceptibility to ventricular arrhythmia, predisposing to syncope, seizures, and sudden death. While rare globally, long QT syndrome is ≈15× more common in First Nations of Northern British Columbia largely because of a known mutation in KCNQ1. However, 2 large multigenerational families were affected, but negative for the known mutation. METHODS AND RESULTS: Long QT syndrome panel testing was carried out in the index case of each family, and clinical information was collected...
January 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28191895/erratum-espl-is-a-bacterial-cysteine-protease-effector-that-cleaves-rhim-proteins-to-block-necroptosis-and-inflammation
#7
Jaclyn S Pearson, Cristina Giogha, Sabrina Mühlen, Ueli Nachbur, Chi L L Pham, Ying Zhang, Joanne M Hildebrand, Clare V Oates, Tania Wong Fok Lung, Danielle Ingle, Laura F Dagley, Aleksandra Bankovacki, Emma J Petrie, Gunnar N Schroeder, Valerie F Crepin, Gad Frankel, Seth L Masters, James Vince, James M Murphy, Margaret Sunde, Andrew I Webb, John Silke, Elizabeth L Hartland
No abstract text is available yet for this article.
February 13, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28191447/reexamining-chronic-toxoplasma-gondii-infection-surprising-activity-for-a-dormant-parasite
#8
Anthony P Sinai, Elizabeth A Watts, Animesh Dhara, Robert D Murphy, Matthew S Gentry, Abhijit Patwardhan
PURPOSE OF REVIEW: Despite over a third of the world's population being chronically infected with Toxoplasma gondii, little is known about this largely asymptomatic phase of infection. This stage is mediated in vivo by bradyzoites within tissue cysts. The absence of overt symptoms has been attributed to the dormancy of bradyzoites. In this review, we reexamine the conventional view of chronic toxoplasmosis in light of emerging evidence challenging both the nature of dormancy and the consequences of infection in the CNS...
December 2016: Current Clinical Microbiology Reports
https://www.readbyqxmd.com/read/28175523/331%C3%A2-association-between-radiation-necrosis-and-tumor-biology-following-stereotactic-radiosurgery-for-brain-metastasis
#9
Jacob A Miller, Elizabeth Emily Bennett, Roy Xiao, Rupesh Kotecha, Samuel T Chao, Michael A Vogelbaum, Gene H Barnett, Lilyana Angelov, Erin Murphy, Jennifer Yu, Manmeet Ahluwalia, John H Suh, Alireza M Mohammadi
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28158412/sex-differences-in-metabolic-cardiomyopathy
#10
Elizabeth Murphy, Georgios Amanakis, Natasha Fillmore, Randi J Parks, Junhui Sun
No abstract text is available yet for this article.
February 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28151003/engaging-diverse-stakeholders-to-inform-biobank-governance
#11
Marie Murphy, Sarah B Garrett, Elizabeth Boyd, Sarah Dry, Daniel Dohan
No abstract text is available yet for this article.
February 2, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28143927/angptl4-does-not-control-hyperglucagonemia-or-%C3%AE-cell-hyperplasia-following-glucagon-receptor-inhibition
#12
Haruka Okamoto, Katie Cavino, Erqian Na, Elizabeth Krumm, Steven Kim, Panayiotis E Stevis, Joyce Harp, Andrew J Murphy, George D Yancopoulos, Jesper Gromada
Genetic disruption or pharmacologic inhibition of glucagon signaling effectively lowers blood glucose but results in compensatory glucagon hypersecretion involving expansion of pancreatic α-cell mass. Ben-Zvi et al. recently reported that angiopoietin-like protein 4 (Angptl4) links glucagon receptor inhibition to hyperglucagonemia and α-cell proliferation [Ben-Zvi et al. (2015) Proc Natl Acad Sci USA 112:15498-15503]. Angptl4 is a secreted protein and inhibitor of lipoprotein lipase-mediated plasma triglyceride clearance...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28143854/erratum-cardiometabolic-risk-in-a-rural-ugandan-population-diabetes-care-2013-36-e143
#13
Georgina A V Murphy, Gershim Asiki, Elizabeth H Young, Janet Seeley, Rebecca N Nsubuga, Manjinder S Sandhu, Anatoli Kamali
No abstract text is available yet for this article.
January 31, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28143853/erratum-the-use-of-anthropometric-measures-for-cardiometabolic-risk-identification-in-a-rural-african-population-diabetes-care-2013-37-e64-e65
#14
Georgina A V Murphy, Gershim Asiki, Rebecca N Nsubuga, Elizabeth H Young, Janet Seeley, Manjinder S Sandhu, Anatoli Kamali
No abstract text is available yet for this article.
January 31, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28115707/glucagon-receptor-inhibition-normalizes-blood-glucose-in-severe-insulin-resistant-mice
#15
Haruka Okamoto, Katie Cavino, Erqian Na, Elizabeth Krumm, Sun Y Kim, Xiping Cheng, Andrew J Murphy, George D Yancopoulos, Jesper Gromada
Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting hyperglycemia is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes. We used the insulin receptor antagonist S961 to induce severe insulin resistance, hyperglycemia, and ketonemia in mice. Using this model, we show that glucagon receptor (GCGR) inhibition with a monoclonal antibody normalized blood glucose and β-hydroxybutyrate levels. Insulin receptor antagonism increased pancreatic β-cell mass threefold...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28112924/discovery-of-pyrrolidine-containing-gpr40-agonists-stereochemistry-effects-a-change-in-binding-mode
#16
Elizabeth A Jurica, Ximao Wu, Kristin N Williams, Andres S Hernandez, David S Nirschl, Richard A Rampulla, Arvind Mathur, Min Zhou, Gary Cao, Chunshan Xie, Biji Jacob, Hong Cai, Tao Wang, Brian J Murphy, Heng Liu, Carrie Xu, Lori K Kunselman, Michael B Hicks, Qin Sun, Dora M Schnur, Doree F Sitkoff, Elizabeth A Dierks, Atsu Apedo, Douglas B Moore, Kimberly A Foster, Mary Ellen Cvijic, Reshma Panemangalore, Neil A Flynn, Brad D Maxwell, Yang Hong, Yuan Tian, Jason J Wilkes, Bradley A Zinker, Jean M Whaley, Joel C Barrish, Jeffrey A Robl, William R Ewing, Bruce A Ellsworth
A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by moving the position of the carboxylic acid, a key pharmacophore for GPR40. Addition of a 4-cis-CF3 to the pyrrolidine improves the human GPR40 binding Ki and agonist efficacy. After further optimization, the discovery of a minor enantiomeric impurity with agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effects on the radioligand used for the binding assay, with (R,R)-68 potentiating the radioligand and (S,S)-68 displacing the radioligand...
February 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28104654/draft-genome-sequence-of-the-acidophilic-halotolerant-and-iron-sulfur-oxidizing-acidihalobacter-prosperus-dsm-14174-strain-v6
#17
Himel Nahreen Khaleque, Joshua P Ramsay, Riley J T Murphy, Anna H Kaksonen, Naomi J Boxall, Elizabeth L J Watkin
The principal genomic features of Acidihalobacter prosperus DSM 14174 (strain V6) are presented here. This is a mesophilic, halotolerant, and iron/sulfur-oxidizing acidophile that was isolated from seawater at Vulcano, Italy. It has potential for use in biomining applications in regions where high salinity exists in the source water and ores.
January 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28103838/race-and-bmi-modify-associations-of-calcium-and-vitamin-d-intake-with-prostate-cancer
#18
Ken Batai, Adam B Murphy, Maria Ruden, Jennifer Newsome, Ebony Shah, Michael A Dixon, Elizabeth T Jacobs, Courtney M P Hollowell, Chiledum Ahaghotu, Rick A Kittles
BACKGROUND: African Americans have disproportionately higher burden of prostate cancer compared to European Americans. However, the cause of prostate cancer disparities is still unclear. Several roles have been proposed for calcium and vitamin D in prostate cancer pathogenesis and progression, but epidemiologic studies have been conducted mainly in European descent populations. Here we investigated the association of calcium and vitamin D intake with prostate cancer in multiethnic samples...
January 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28077418/a-novel-humanized-mouse-model-with-significant-improvement-of-class-switched-antigen-specific-antibody-production
#19
Hua Yu, Chiara Borsotti, Jean-Nicolas Schickel, Shu Zhu, Till Strowig, Elizabeth E Eynon, Davor Frleta, Cagan Gurer, Andrew J Murphy, George D Yancopoulos, Eric Meffre, Markus G Manz, Richard A Flavell
Humanized mice are a powerful tool for the study of human hematopoiesis and immune function in vivo. However, the existing models cannot support robust adaptive immune responses, especially the generation of class-switched, antigen-specific antibody responses. Here we describe a new mouse strain, in which human interleukin 6 (IL-6) gene encoding the cytokine that is important for B- and T-cell differentiation was knocked into its respective mouse locus. The provision of human IL-6 not only enhanced thymopoiesis and periphery T-cell engraftment, but also significantly increased class switched memory B cells and serum immunoglobulin G (IgG)...
February 23, 2017: Blood
https://www.readbyqxmd.com/read/28033512/the-beliefs-about-paranoia-scale-confirmatory-factor-analysis-and-tests-of-a-metacognitive-model-of-paranoia-in-a-clinical-sample
#20
Elizabeth K Murphy, Sarah Tully, Melissa Pyle, Andrew I Gumley, David Kingdon, Matthias Schwannauer, Douglas Turkington, Anthony P Morrison
This study aimed to confirm the factor structure of the Beliefs about Paranoia Scale (BaPS), a self-report measure to assess metacognitive beliefs about paranoia, and to test hypotheses of a metacognitive model. We hypothesised that positive and negative beliefs about paranoia would be associated with severity of suspiciousness, and that the co-occurrence of positive and negative beliefs would be associated with increased suspiciousness. A total of 335 patients meeting criteria for a schizophrenia spectrum disorder completed the BaPS, the Positive and Negative Syndromes Scale (PANSS), and the Psychotic Symptom Rating Scales (PSYRATS)...
November 12, 2016: Psychiatry Research
keyword
keyword
40778
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"